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Supplement Facts
Serving Size: 1 tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
2 mg
118%
Folate (as folic acid)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41667%
The product is found useful for the following medical conditions
Anemia details
SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8
USERS' SCORE
Good
Based on 20 Reviews
8.9
9.5
Vitamin B6 improves anemia outcomes
Recurrent sideroblastic anemia during pregnancy.
Most Relevant Research
We observed a compelling case involving a 32-year-old pregnant woman who experienced severe anemia during her pregnancy. This specific type of anemia, known as sideroblastic anemia, is quite rare in expectant mothers. The patient had been feeling weak and had heart palpitations for two weeks when she came to the emergency room.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
8.8
Calmer emotions
Most Useful Review
B12 is essential for maintaining good iron stores, and its active form is well absorbed. I noticed that low B12 can lead to irritability and aggression, so I supplement with B vitamins, especially B12 and magnesium glycinate, which helps me feel calmer and reduces anxiety. I find that B vitamins are a necessity for me. Although this product includes inactive forms of B6 and folic acid, its effectiveness for hair health is excellent. The tablets taste unpleasant but dissolve quickly.
Bone Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 10 Reviews
8.8
8
Folic acid alleviates bone pain
Folic acid relieves bone cancer pain by downregulating P2X2/3 receptors in rats.
Most Relevant Research
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
9.5
Relief from pain
Most Useful Review
I highly recommend it. After exercising, I often feel tired and experience bone pain. Taking this product helps me recover, and I feel fine by the next day. My mother also uses it for her hands, which often hurt from cleaning and cooking. After taking a pill, she wakes up pain-free the next day. I was advised by a doctor to use it, as it has numerous benefits, including energy restoration and relief from bone pain.
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 7 Reviews
8.7
9
Vitamin B6 reduces cholesterol levels
Antihyperlipidemic and Hepatoprotective Properties of Vitamin B6 Supplementation in Rats with High-Fat Diet-Induced Hyperlipidemia.
Most Relevant Research
We aimed to understand how Vitamin B6 influences high cholesterol levels, particularly through its effects on lipid metabolism in rats induced by a high-fat diet. To set the stage for our exploration, we used male Sprague-Dawley rats and placed them on this fat-rich diet for two weeks to establish a hyperlipidemia model.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
8.8
Supports cholesterol management
Most Useful Review
An essential vitamin for MS, B12 is crucial for myelin health and red blood cell production. I experienced great benefits from taking methylcobalamin with B6 and folic acid, initially daily, then every other day. B12 can help manage high cholesterol and is vital for brain and nerve health. Those with MS should be cautious if they have blood clotting tendencies. Other MS supplements are reviewed on my page.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Pernicious anemia treatment effectiveness
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
Most Relevant Research
We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
9.5
Effective treatment
Most Useful Review
I received a recommendation to order this product during my first visit to the reproductologist. Tests indicated a tendency towards folic acid deficiency and elevated homocysteine levels. After a month of taking the product, my indicators improved significantly and were adjusted to the desired limits. Conclusion: this product is effective, and I plan to continue taking it regularly.
Chest Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.5
USERS' SCORE
Good
Based on 4 Reviews
8.6
8
Vitamin B6 and cardiac health
Prevention of myocardial infarction by vitamin B6.
Most Relevant Research
We evaluated the impact of vitamin B6 on chest pain and its potential role in preventing related cardiac issues. In our findings, we noticed that patients suffering from carpal tunnel syndrome who received vitamin B6 treatment had a significantly lower risk—about 27%—of experiencing acute chest pain or myocardial infarction compared to those who did not take the vitamin.
Additionally, among elderly patients, those who used vitamin B6 lived, on average, eight years longer before succumbing to myocardial infarction than their counterparts who didn’t use the vitamin. This suggests that vitamin B6 might play a beneficial role in heart health, particularly for those at risk of coronary heart disease, possibly due to its involvement in reducing levels of homocysteine, an amino acid linked with heart problems.
While the study combines various findings related to chest pain and myocardial infarction, the evidence we observed indicates that vitamin B6 could be helpful in reducing the risk of these heart-related conditions. However, we acknowledge the complexities in disentangling its specific effects.
Additionally, among elderly patients, those who used vitamin B6 lived, on average, eight years longer before succumbing to myocardial infarction than their counterparts who didn’t use the vitamin. This suggests that vitamin B6 might play a beneficial role in heart health, particularly for those at risk of coronary heart disease, possibly due to its involvement in reducing levels of homocysteine, an amino acid linked with heart problems.
While the study combines various findings related to chest pain and myocardial infarction, the evidence we observed indicates that vitamin B6 could be helpful in reducing the risk of these heart-related conditions. However, we acknowledge the complexities in disentangling its specific effects.
9.5
Reduced tension
Most Useful Review
The product is excellent. I experienced chest pain and muscle tension due to Vitamin B12 deficiency, but after using this product for two days, the tension significantly eased. I continued for ten days and stopped when symptoms improved. The quality is great, and the taste is pleasant, with ample packaging lasting a long time, used only during symptoms for better health 🌹.
Heart Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 25 Researches
8
USERS' SCORE
Good
Based on 7 Reviews
8.6
9
Folic acid reduces CHD risk
Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population.
Most Relevant Research
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
9.5
Improves heart metabolism
Most Useful Review
B12 is in a natural form that enhances metabolism, lowers cholesterol, and supports digestion. It's also involved in nutrient synthesis and heart functioning. The small tablets have a slightly sour taste and are suitable for those over 50 to maintain cognitive health.
Vertigo details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
ISSHL treatment with BPPV outcomes
[Treatment outcome of patients with idiopathic sudden sensorineural hearing loss and concomitant benign paroxysmal positional vertigo].
Most Relevant Research
We explored the effectiveness of various treatments for patients experiencing idiopathic sudden sensorineural hearing loss (ISSHL) along with benign paroxysmal positional vertigo (BPPV). In a group of 252 ISSHL patients, 96 were found to have complicating vertigo, categorized into those without vertigo, those with non-BPPV vertigo, and those with BPPV.
The treatment regimen included intravenous urokinase and a combination of vitamins, including vitamin B6. While we witnessed improvements in hearing for all groups, those with BPPV and those without vertigo showed similar progress. However, patients with non-BPPV vertigo experienced significantly less improvement regarding their hearing.
Notably, the vertigo symptoms resolved completely in the ISSHL patients with BPPV following the canalith repositioning maneuver. Despite vitamin B6 being part of the treatment, we could not isolate its specific effect on vertigo, as it was used alongside other medications. Overall, patients with BPPV had a relatively favorable outcome from both their hearing and vertigo symptoms after treatment.
The treatment regimen included intravenous urokinase and a combination of vitamins, including vitamin B6. While we witnessed improvements in hearing for all groups, those with BPPV and those without vertigo showed similar progress. However, patients with non-BPPV vertigo experienced significantly less improvement regarding their hearing.
Notably, the vertigo symptoms resolved completely in the ISSHL patients with BPPV following the canalith repositioning maneuver. Despite vitamin B6 being part of the treatment, we could not isolate its specific effect on vertigo, as it was used alongside other medications. Overall, patients with BPPV had a relatively favorable outcome from both their hearing and vertigo symptoms after treatment.
9.5
Dizziness resolved
Most Useful Review
I was anaemic before taking Vegan B12 with folic acid and B6, experiencing dizziness akin to vertigo. After taking one tablet daily alongside a Vitamin B complex, my dizziness has decreased significantly. Now, after a month, it has completely vanished. My hair also no longer falls out easily. Thank you very much.
Back Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 22 Researches
8.3
USERS' SCORE
Good
Based on 7 Reviews
8.5
9
Vitamin B12 aids low back pain
Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.
Most Relevant Research
We conducted a thorough investigation to understand whether intramuscular vitamin B12 treatment could effectively relieve low back pain. This study was designed as a double-blind, placebo-controlled trial involving 60 patients aged 18 to 65 who suffered from mechanical low back pain or sciatic neuritis. Each participant had a history of back pain lasting from six months to five years and reported significant pain intensity according to a standard scale.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
9.5
Relieved back pain
Most Useful Review
This product is remarkable. A deficiency in Vitamin B12 has caused me joint pain and muscle tension in my back, particularly on the right side. I experienced relief just two days after starting the supplement, which has been effective in alleviating my back pain. I recommend using it temporarily during symptoms, as the quality is excellent.
Knee Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.5
7
Folate linked to reduced knee pain
Associations between folate intake and knee pain, inflammation mediators and comorbid conditions in patients with symptomatic knee osteoarthritis.
Most Relevant Research
We explored the relationship between folate intake and knee pain in patients suffering from knee osteoarthritis (OA) over a two-year period. In this insightful study, data was collected from participants enrolled in a rigorous clinical trial designed to assess the effects of vitamin D supplementation. While the original trial focused on vitamin D, our post-hoc analysis allowed us to dive into the potential benefits of folate on knee pain and related conditions.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
Through the use of dietary questionnaires, we assessed the average daily folate consumption of participants. In addition to evaluating knee pain levels at various intervals, other factors such as inflammatory markers, muscle strength, and comorbidities were also monitored. Impressively, we found that increased folate intake was associated with reduced knee pain and lower levels of inflammatory substances known as adipokines.
Furthermore, individuals with higher folate consumption reported fewer comorbid conditions, suggesting that folate may indeed play a role in enhancing overall health for those dealing with knee OA. However, while our findings are promising, they highlight the need for further research to fully understand the extent of folate's impact in this context.
8.8
Relieved tension
Most Useful Review
The product is excellent. I initially suffered from knee pain alongside symptoms of Vitamin B12 deficiency, such as joint discomfort and muscle tension. After using this product for just two days, it alleviated much of the tension. I used it for ten days and found great improvement. The quality is superb, with a pleasant sweet taste, and the packaging lasts a long time since it’s only needed during symptom flare-ups. Overall, I experienced significant health benefits.
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.5
8.8
Relieves leg cramps
Most Useful Review
Excellent! It relieved much of the tingling in my hands and legs.
