Jarrow Formulas BoneUp

Supplement Facts

Serving Size: 1 Capsule

Amount Per Serving

%DV

Vitamin C (as Ascorbic Acid)

33.3 mg

37%

Vitamin D (as D3 Cholecalciferol)

8.3 mcg (333 IU)

42%

Calcium (Elemental)(from Microcrystalline Hydroxyapatite)

333.3 mg

26%

Magnesium (as Magnesium Oxide)

116.7 mg

28%

Zinc (as Zinc L-Methionine Sulfate)

3.3 mg

30%

Copper (as Copper Gluconate)

0.333 mg

37%

Manganese (as Manganese Citrate)

0.333 mg

14%

Vitamin K2 (as Natural MK-7 [Menaquinone-7])

15 mcg

†

Boron (as Boron Citrate)

1 mg

†

The product is found useful for the following medical conditions

We examined how hyperoside, a compound in Semen cuscutae, can combat osteoporosis in ovariectomized mice, particularly after menopause. The study revealed that hyperoside effectively increased bone density and improved bone structure by reducing the differentiation of osteoclasts—cells that break down bone.

Our findings indicated that the anti-osteoporotic effects of hyperoside are linked to the estrogen receptor α, as blocking this receptor reversed its benefits. Ultimately, hyperoside shows promise in protecting against osteoporosis through its actions on specific signaling pathways.

Normalised density

Most Useful Review

381 people found this helpful

I reversed osteopenia! I have taken Bone-Up by Jarrow Formulas for years after being diagnosed with osteopenia. I committed to taking it daily; my osteopenia eventually reversed, and my bone density is now normal. I engage in regular weight-bearing exercise which supports bone health. Despite previous thinning bone loss, I was able to reverse it through determination and consistent use of Jarrow Bone-Up. I won’t stop taking this for life!

Updated: Mar 2026

Attention Deficit Hyperactivity Disorder details

1 people found this helpful

To be honest, I would never buy this supplement myself; initially, only the brand appealed to me. The composition did not convince me, but a doctor I trust prescribed it (alongside other drugs for knee function restoration). Skeptical at first, I found that the pain disappeared as long as I continued taking it. I even tried it on my mother, who has the same issue, and she too experienced relief. Despite her aversion to pills, she found it tolerable. I recommend it.

Updated: Mar 2026

Autoimmune Disorder details

Supports calcium needs

Most Useful Review

2 people found this helpful

I order this for my mother, who has an autoimmune disorder and needs calcium constantly, especially while taking Metipred. Her indicators are good, and she continues taking the complex. Three capsules are preferable for her than six due to the sheer number of medications she takes daily. However, we need to supplement with extra vitamins, which we monitor through tests.

Updated: Mar 2026

Knee Pain details

SCIENTIFIC SCORE

Likely Very Effective

Enhanced knee pain outcomes with MOPS

Buyuk AF, Stannard JP, Rucinski K, Crecelius CR, Cook JL. The Missouri Osteochondral Preservation System Is Associated With Better Short-Term Outcomes Than Standard Preservation Methods When Performing Osteochondral Allograft Transplantation Using Shell Grafts for Patellofemoral Lesions. Arthroscopy. 2023;39:650. doi:10.1016/j.arthro.2022.10.007

We examined the effectiveness of the Missouri Osteochondral Preservation System (MOPS) compared to standard preservation methods for treating knee pain after osteochondral allograft (OCA) transplantation.

Our study revealed that patients receiving MOPS shell grafts experienced significant improvements in pain and function after two years.

Specifically, MOPS showed an impressive 98% functional graft survival rate, contrasted with 83% for standard methods.

Moreover, unipolar patella allograft patients reported the greatest relief and functionality, indicating that MOPS may offer superior short-term outcomes for knee pain.

Significant pain relief

Most Useful Review

2 people found this helpful

This supplement seems to be my solution. I've tried various supplements targeting the musculoskeletal system. Due to this year's persistent rain and a personal tragedy, all my joints and lower back (intervertebral hernias) have been painful. I discovered that a deficiency in calcium can also lead to joint discomfort, which led me to choose this supplement. While I wouldn't claim a miracle, my pains have considerably reduced, and this improvement is undoubtedly linked to this supplement, as I am not currently using painkillers or any other medications. It's unfortunate that regular use isn't advisable. I also appreciate the composition, though I prefer taking magnesium at night as it's more beneficial for me then. Overall, I am very satisfied with this supplement and have no desire to experiment with others.

Updated: Mar 2026

Leg Cramps details

6 people found this helpful

Helped with leg cramps. My friend suffered such severe leg cramps that she cried at night. I gave her some of these to try and the cramps entirely disappeared—until she ran out. Then they returned. I believe the 2:1 Calcium: Magnesium ratio helped her, along with the added Vitamin C for absorption. I usually take four caps with a multi-vitamin and Evening Primrose Oil.

Updated: Mar 2026

Back Pain details

SCIENTIFIC SCORE

Moderately Effective

Based on 3 Researches

BSHXF shows promise for low-back pain

Zhan JW, Li KM, Zhu LG, Wang SQ, Feng MS, et al. Efficacy and Safety of Bushen Huoxue Formula in Patients with Discogenic Low-Back Pain: A Double-Blind, Randomized, Placebo-Controlled Trial. Chin J Integr Med. 2022;28:963. doi:10.1007/s11655-022-3505-4

We conducted a double-blind, randomized trial to see how well the Bushen Huoxue Formula (BSHXF) works for discogenic low-back pain. Seventy patients received either BSHXF or a placebo alongside lumbar traction for three weeks.

Our results showed that those taking BSHXF experienced significantly less pain and better mobility compared to the control group. Notably, their improvement in function and muscle tone was maintained even one to three months after treatment, with no adverse effects reported.

This suggests that BSHXF might be an effective option for alleviating low-back pain.

Eliminates back pain

Most Useful Review

10 people found this helpful

Major change after starting this. After breastfeeding for 12 months, I was in constant pain across my back, knees, and joints. Suggestions led me to this calcium supplement. Just three days in, nearly all my pain had vanished! Now pregnant again, my midwives say I’m the only woman in their practice with adequate vitamin D levels, thanks to this supplement. In summary, it’s the best and I urge everyone with bone issues to try it.

Updated: Mar 2026

Bone Pain details

SCIENTIFIC SCORE

Moderately Effective

Based on 2 Researches

USERS' SCORE

Good

Based on 35 Reviews

Complementary medicine aids hormone therapy

Beuth J, Van Leendert R, Pempelfort K, Schneider B, Grund C, et al. Complementary medicine down-regulates side-effects of hormone therapy in prostate cancer patients. In Vivo. 2014;28:979.

We evaluated the impact of complementary medicine on the side-effects of hormone therapy in prostate cancer patients. In a study of 93 patients experiencing severe side-effects, we utilized sodium selenite, plant enzymes, and Lc-lectin. Over 50 days, we documented noticeable reductions in bone pain and other side-effects. Specifically, bone pain severity decreased significantly from a score of 4.74 to 2.82. This suggests that complementary treatments can be beneficial in managing hormone therapy side-effects.

Pain relief solution

Most Useful Review

17 people found this helpful

I purchased this product following a recommendation from a nutritionist owing to my osteopenia. Within weeks, it completely alleviated the hip pain I was experiencing. I lead an active lifestyle and wish to reverse the damage done by genetics and family history of osteoporosis. I plan to continue taking this product as long as needed and even advised my brother-in-law, who experienced similar relief. You really don’t have to suffer!