Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin D (as cholecalciferol)
125 mcg
625%
Iodine [from Sea-Iodine™ Complex Blend (organic kelp and bladderwrack extracts, potassium iodide)]
1,000 mcg
667%
The product is found useful for the following medical conditions
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Good
Based on 6 Reviews
8.7
8
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
9
Boosts immunity
Most Useful Review
Energy source: An excellent medication that has significantly improved my immunity and alleviated fatigue and drowsiness during the day. It does not cause allergies, is a convenient tablet size, and has no strong odour or taste. I wholeheartedly recommend it.
Bone Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Good
Based on 7 Reviews
8.5
9
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
10
Improved energy levels
Most Useful Review
1 people found this helpful
This D3 has revitalised me! My bone pain has lessened, and my thyroid function returned to normal within ten days. I recommend taking it with food for best results.
Heart Disease details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.9
USERS' SCORE
Good
Based on 5 Reviews
8.4
7
Vitamin D's role in heart health
We examined how low levels of vitamin D (Vit D) could impact the severity of heart disease, specifically looking at myocardial ischemia. Our study involved two hundred patients who underwent myocardial perfusion imaging at Namazi Hospital in Shiraz, Iran, in 2019. We assessed both the severity of ischemia in patients and their vitamin D levels.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
9
High dose availability
Most Useful Review
1 people found this helpful
D3 is essential for heart disease; I’m pleased to find higher doses here, which aren’t available in New Zealand.
Leg Cramps details
SCIENTIFIC SCORE
Very Likely Ineffective
Based on 2 Researches
2
USERS' SCORE
Good
Based on 2 Reviews
8.3
4
We assessed the impact of vitamin D on leg cramps experienced during pregnancy, referring to data from various studies. One of the key findings was that vitamin D treatment showed little to no difference when it came to reducing the frequency of leg cramps.
In a trial involving 84 women, participants who received vitamin D did not see significant changes in the frequency of leg cramps after three weeks or six weeks post-treatment. This suggests that, while vitamin D is often discussed in the context of health benefits, its effectiveness for leg cramps specifically might be quite limited.
Overall, the evidence we reviewed highlights the need for caution. The findings suggest that vitamin D may not be a viable treatment option for managing leg cramps during pregnancy, indicating a need for more robust research in this area.
In a trial involving 84 women, participants who received vitamin D did not see significant changes in the frequency of leg cramps after three weeks or six weeks post-treatment. This suggests that, while vitamin D is often discussed in the context of health benefits, its effectiveness for leg cramps specifically might be quite limited.
Overall, the evidence we reviewed highlights the need for caution. The findings suggest that vitamin D may not be a viable treatment option for managing leg cramps during pregnancy, indicating a need for more robust research in this area.
7.5
Nails improved
Most Useful Review
Good dosage and an excellent combination of iodine and vitamin D. After using this supplement for a month, my nails improved, and I stopped experiencing leg cramps while walking. My eyebrows have also become thicker.
Osteoporosis details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.4
USERS' SCORE
Good
Based on 3 Reviews
8.3
8
We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
7.5
Levels normalised
Most Useful Review
Great for my arthritis and Osteoporosis; it has helped normalise my levels.
Pelvic Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.3
7.5
Improved sleep
Most Useful Review
1 people found this helpful
Presented to my mother-in-law (74) who suffers from constant joint pain and relies on pain relievers and massages. She had difficulty sleeping. After starting Vitamin D3, she began to sleep peacefully after a week.
Cold details
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.8
USERS' SCORE
Good
Based on 17 Reviews
8.1
8
We explored the connection between vitamin D levels and upper respiratory tract infections (URTIs) among military recruits during their training. This observation spanned across different seasons and included over 1,600 recruits. Our aim was to understand how achieving sufficient vitamin D levels could potentially impact the frequency and severity of colds among physically active individuals.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
9
Positive cold recovery
Most Useful Review
A good choice for vitamin D. I have been taking it for a month and feel positive effects. I gained strength, and the cold I had passed quickly.
Hypothyroidism details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
USERS' SCORE
Good
Based on 9 Reviews
8.1
9.5
We looked into the growing concern of iodine deficiency hypothyroidism among children in the United States. This condition, which can lead to cognitive and physical impairments, was thought to be largely eliminated thanks to universal salt iodization started in the 1920s. However, recent trends suggest that iodine deficiency could be reappearing due to increased use of noniodized salts, lower iodine levels in dairy, and dietary restrictions like veganism or food allergies.
Over an 18-month period, we documented a series of cases where three children were diagnosed with iodine deficiency hypothyroidism despite having no underlying thyroid dysfunction. Their clinical presentations varied significantly—some had large goiters while others showed mild or no goiter at all. The results of their biochemical tests also highlighted a range of thyroid-stimulating hormone elevations.
Importantly, all patients returned to normal thyroid function following iodine supplementation. We propose that measuring spot urine iodine levels alongside elevated serum thyroglobulin could serve as a simpler and effective diagnostic approach, moving away from the more complex 24-hour urinary iodine tests. Our findings shine a light on the necessity of addressing iodine deficiency in today’s dietary landscape.
Over an 18-month period, we documented a series of cases where three children were diagnosed with iodine deficiency hypothyroidism despite having no underlying thyroid dysfunction. Their clinical presentations varied significantly—some had large goiters while others showed mild or no goiter at all. The results of their biochemical tests also highlighted a range of thyroid-stimulating hormone elevations.
Importantly, all patients returned to normal thyroid function following iodine supplementation. We propose that measuring spot urine iodine levels alongside elevated serum thyroglobulin could serve as a simpler and effective diagnostic approach, moving away from the more complex 24-hour urinary iodine tests. Our findings shine a light on the necessity of addressing iodine deficiency in today’s dietary landscape.
7.5
Increased energy levels
Most Useful Review
14 people found this helpful
I switched to a simpler iodine with vitamin K and appreciate the capsule size, which is easy to swallow. The vegetable iodine dosage is high, but not fully absorbed due to my hypothyroidism. My endocrinologist approved its use, and I take it alongside selenium for better absorption. After three months, I feel increased energy and recommend it.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.4
USERS' SCORE
Good
Based on 3 Reviews
8
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
9
Boosted energy levels
Most Useful Review
I ordered vitamin D3 with iodine and Omega-3 on my endocrinologist's advice after low levels were found in my tests. After three months, my overall health improved, and I felt energised. I noticed weight loss alongside proper nutrition and exercise, combating springtime fatigue and lack of sleep. Now, my mood is excellent. I plan to order more and take a course annually in winter to help with my autoimmune disorder.
Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.4
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.9
9
Iodine treatment aids recurrent cancer
We observed a compelling case where a biodegradable hydrogel spacer was used alongside iodine-125 brachytherapy to treat recurrent prostate cancer. This innovative approach involved placing the spacer to create space between the prostate and the rectum, which significantly reduced radiation exposure to healthy tissues during the treatment.
Following initial external beam radiotherapy in 2015, the patient showed signs of local recurrence by 2022. To address this, the treatment plan included not just the iodine-125 brachytherapy but also the hydrogel spacer, which was placed in January 2024 just before the radiation treatment. Six months later, we noted a remarkable drop in the patient’s prostate-specific antigen (PSA) levels, indicating a positive response to the treatment.
This case showcases the potential benefits of using iodine treatment in combination with advanced techniques like hydrogel spacers. The results suggest that this method not only improves the effectiveness of therapy but also ensures higher safety by protecting adjacent tissues from unnecessary radiation damage. Overall, we find this integration of technology highly beneficial for managing recurrent cancer challenges.
Following initial external beam radiotherapy in 2015, the patient showed signs of local recurrence by 2022. To address this, the treatment plan included not just the iodine-125 brachytherapy but also the hydrogel spacer, which was placed in January 2024 just before the radiation treatment. Six months later, we noted a remarkable drop in the patient’s prostate-specific antigen (PSA) levels, indicating a positive response to the treatment.
This case showcases the potential benefits of using iodine treatment in combination with advanced techniques like hydrogel spacers. The results suggest that this method not only improves the effectiveness of therapy but also ensures higher safety by protecting adjacent tissues from unnecessary radiation damage. Overall, we find this integration of technology highly beneficial for managing recurrent cancer challenges.
7.5
Aids bone health
Most Useful Review
I take vitamin D3 constantly; it ensures normal growth and development of bones, preventing rickets and osteoporosis. It regulates mineral metabolism, promotes muscle tone, improves immunity, and is vital for thyroid function and blood clotting. It also helps restore protective sheaths around nerves and regulates blood pressure and heartbeat while inhibiting cancer cell growth. Good company and optimal dosage for winter. You can take it every other day if necessary.
