Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (From Lanolin)
1,250 mcg (50,000 IU)
6250%
The product is found useful for the following medical conditions
Cold details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.3
USERS' SCORE
Good
Based on 43 Reviews
8.9
8
Vitamin D reduces cold severity
Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training.
Most Relevant Research
We explored the connection between vitamin D levels and upper respiratory tract infections (URTIs) among military recruits during their training. This observation spanned across different seasons and included over 1,600 recruits. Our aim was to understand how achieving sufficient vitamin D levels could potentially impact the frequency and severity of colds among physically active individuals.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
8.8
Cold prevention
Most Useful Review
For temporary cold prevention, I take a single dose with vitamin K2 when someone near me has a cold. It appears to be effective. I ensure a week's gap between doses due to potential overdose risks, as noted on the manufacturer's site.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.5
USERS' SCORE
Good
Based on 25 Reviews
8.8
2
Vitamin D3 ineffective for CFS
Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome--a randomised controlled trial.
Most Relevant Research
We conducted a thorough investigation into whether high-dose intermittent vitamin D3 could alleviate symptoms of chronic fatigue syndrome (CFS) and improve vascular health. This double-blind, randomized placebo-controlled trial involved patients meeting established criteria for CFS. Participants received either 100,000 units of vitamin D3 or a placebo every two months for six months.
Over the course of the study, we measured key outcomes such as arterial stiffness, blood pressure, cholesterol levels, and fatigue levels through various tests. Surprisingly, our findings showed that vitamin D3 treatment did not lead to any significant improvements in these areas. We observed only a slight increase in vitamin D levels in the treatment group, but this did not translate into better vascular health or reduced fatigue.
In conclusion, we honestly found that high-dose vitamin D3 did not offer any notable benefits for patients struggling with chronic fatigue syndrome. This study highlights the complexities of treating CFS and suggests that vitamin D3 may not be the solution some had hoped for.
Over the course of the study, we measured key outcomes such as arterial stiffness, blood pressure, cholesterol levels, and fatigue levels through various tests. Surprisingly, our findings showed that vitamin D3 treatment did not lead to any significant improvements in these areas. We observed only a slight increase in vitamin D levels in the treatment group, but this did not translate into better vascular health or reduced fatigue.
In conclusion, we honestly found that high-dose vitamin D3 did not offer any notable benefits for patients struggling with chronic fatigue syndrome. This study highlights the complexities of treating CFS and suggests that vitamin D3 may not be the solution some had hoped for.
9.5
Improved alertness
Most Useful Review
I visited a therapist due to chronic fatigue syndrome and discovered I was deficient in vitamin D. This vitamin is crucial for maintaining healthy bones and the immune system. After replenishing my levels, my energy improved significantly, and I became more active.
Common Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.1
USERS' SCORE
Good
Based on 12 Reviews
8.8
8
Vitamin D3 improves cold symptoms
Intake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study.
Most Relevant Research
We conducted a thorough investigation into how 25-hydroxyvitamin D3, commonly referred to as vitamin D3, impacts upper respiratory tract infections (URTIs), particularly the common cold. This study was carried out as a randomized, double-blind, placebo-controlled trial, engaging 428 participants, all aged between 45 and 74, across three clinics in Japan.
Participants were divided into two groups, with one receiving a daily dose of 10 μg of vitamin D3, while the other took a placebo for 16 weeks. Our findings highlighted that those who took vitamin D3 experienced a reduction in the duration of their upper respiratory symptoms, as well as a decrease in severity and improvement in their quality of life during illness.
Overall, our results indicate that supplementing with vitamin D3 might be a proactive step in handling the discomforts associated with common colds. This simple addition to one's daily routine could lead to a notably better experience when facing URTIs, providing a hopeful outlook for those looking for relief from their symptoms.
Participants were divided into two groups, with one receiving a daily dose of 10 μg of vitamin D3, while the other took a placebo for 16 weeks. Our findings highlighted that those who took vitamin D3 experienced a reduction in the duration of their upper respiratory symptoms, as well as a decrease in severity and improvement in their quality of life during illness.
Overall, our results indicate that supplementing with vitamin D3 might be a proactive step in handling the discomforts associated with common colds. This simple addition to one's daily routine could lead to a notably better experience when facing URTIs, providing a hopeful outlook for those looking for relief from their symptoms.
9.5
Effective dosage
Most Useful Review
A brilliant vitamin D dosage that really works! I take a capsule every ten days during winter and have consistently maintained my vitamin levels, which helps prevent the common cold.
Leg Cramps details
SCIENTIFIC SCORE
Very Likely Ineffective
Based on 2 Researches
2
USERS' SCORE
Good
Based on 6 Reviews
8.8
4
We assessed the impact of vitamin D on leg cramps experienced during pregnancy, referring to data from various studies. One of the key findings was that vitamin D treatment showed little to no difference when it came to reducing the frequency of leg cramps.
In a trial involving 84 women, participants who received vitamin D did not see significant changes in the frequency of leg cramps after three weeks or six weeks post-treatment. This suggests that, while vitamin D is often discussed in the context of health benefits, its effectiveness for leg cramps specifically might be quite limited.
Overall, the evidence we reviewed highlights the need for caution. The findings suggest that vitamin D may not be a viable treatment option for managing leg cramps during pregnancy, indicating a need for more robust research in this area.
In a trial involving 84 women, participants who received vitamin D did not see significant changes in the frequency of leg cramps after three weeks or six weeks post-treatment. This suggests that, while vitamin D is often discussed in the context of health benefits, its effectiveness for leg cramps specifically might be quite limited.
Overall, the evidence we reviewed highlights the need for caution. The findings suggest that vitamin D may not be a viable treatment option for managing leg cramps during pregnancy, indicating a need for more robust research in this area.
9.5
Pain relief noted
Most Useful Review
I had pain in my lower back and legs due to a vitamin D deficiency, but after taking it, the pain disappeared.
Anemia details
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.7
USERS' SCORE
Good
Based on 3 Reviews
8.7
7
Vitamin D3's role in anemia
Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: Protocol for an 8-week, parallel group, double-blind randomized controlled trial.
Most Relevant Research
We conducted a study to see how vitamin D3 might help improve iron levels in women of childbearing age who had marginally low iron stores. Our approach involved a carefully designed 8-week randomized controlled trial, where 120 women aged between 19 and 40 were divided into two groups. One group received fruit juice fortified with 4000 IU of vitamin D3 daily, while the other had a placebo juice.
Throughout the study, we collected blood samples and monitored various health indicators every four weeks. We aimed to find out if the vitamin D3 supplementation could positively influence the iron status of the participants compared to the placebo.
Given the promising role of vitamin D in enhancing iron absorption, we hoped to uncover new insights into dietary strategies for managing iron deficiency. By observing the interaction over time between vitamin D levels and iron status, we aimed to provide valuable information on whether this fortification could serve as a practical alternative to traditional iron supplements.
As we gathered data, we explored the potential of vitamin D3 beyond its usual role, assessing if it could indeed help improve the anemia indicators in our target group.
Throughout the study, we collected blood samples and monitored various health indicators every four weeks. We aimed to find out if the vitamin D3 supplementation could positively influence the iron status of the participants compared to the placebo.
Given the promising role of vitamin D in enhancing iron absorption, we hoped to uncover new insights into dietary strategies for managing iron deficiency. By observing the interaction over time between vitamin D levels and iron status, we aimed to provide valuable information on whether this fortification could serve as a practical alternative to traditional iron supplements.
As we gathered data, we explored the potential of vitamin D3 beyond its usual role, assessing if it could indeed help improve the anemia indicators in our target group.
9.5
Effective for anemia
Most Useful Review
WONDERFUL!!! It does not harm the stomach or intestines. It is excellent for treating hair loss, anaemia, and aiding thyroid function.
Arthritis details
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.8
USERS' SCORE
Good
Based on 9 Reviews
8.7
8
Vitamin D aids rheumatoid arthritis
The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review.
Most Relevant Research
We explored how vitamin D plays a role in managing rheumatoid arthritis (RA), a condition that causes joint inflammation and discomfort. It's been found that many people with RA often suffer from vitamin D deficiency, which may worsen their symptoms and overall disease severity.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
8.8
Improved immunity
Most Useful Review
The most crucial vitamin the body requires is vitamin D3, especially for those with arthritis or other immune disorders. It has significantly helped me as a rheumatoid arthritis sufferer by enhancing immunity and alleviating pain. I take it with a fatty meal, along with K2, to improve absorption and support calcium utilisation in the bones. The capsules are natural and of high quality, and they're reasonably priced.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.5
USERS' SCORE
Good
Based on 28 Reviews
8.7
9
Vitamin D3 modulates autoimmune response
Vitamin D3 attenuates autoimmune thyroiditis by regulating Th17/Treg cell differentiation via YAP/JAK1/STAT1 axis.
Most Relevant Research
We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
8.8
Improved health
Most Useful Review
A good quality vitamin at a high dosage and an adequate price. I take it weekly in winter due to the lack of sunlight in Germany, which has contributed to my autoimmune disorders. Thank you, iHerb, for such a great offer. Capsules here are costly, so this is a brilliant alternative after being homebound.
Bone Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Good
Based on 64 Reviews
8.7
9
Vitamin D3 correction improves pain
Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty.
Most Relevant Research
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
8.8
Bone pain relief
Most Useful Review
After using the supplement for 4 months, my vitamin D levels improved significantly. I experienced a 50% decrease in hair loss, and bone pain is no longer an issue. My memory has also improved greatly, with no sign of forgetfulness. The capsules are easy to swallow.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.1
USERS' SCORE
Good
Based on 11 Reviews
8.7
9
Vitamin D3 improves depressive symptoms
Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial.
Most Relevant Research
We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.
9.5
Enhanced immunity
Most Useful Review
The most important vitamin for the body is vitamin D3, especially for those with immune issues, joint pain, and depression. As someone with rheumatoid arthritis, I find it crucial. It boosts immunity and alleviates psychological distress. It’s more effective than cortisone. Take it with a fatty meal and alongside vitamin K2 for better absorption. The capsules are tasteless, well-packaged, and a good value. I hope this helps you! Always be grateful for your condition.
Fibromyalgia details
SCIENTIFIC SCORE
Questionable
Based on 25 Researches
6.4
USERS' SCORE
Good
Based on 9 Reviews
8.7
9
Vitamin D improves fibromyalgia symptoms
The effect of vitamin D treatment on quality of life in patients with fibromyalgia.
Most Relevant Research
We aimed to explore the effectiveness of vitamin D supplementation in alleviating the symptoms of fibromyalgia—a condition marked by chronic pain, fatigue, and cognitive challenges. Our research included a group of 180 women, aged 18 to 65, who met the criteria for fibromyalgia. We administered a high-dose vitamin D3 supplement of 50,000 IU over a span of 12 weeks and assessed the impact on their quality of life through the Fibromyalgia Impact Questionnaire (FIQ) and the Visual Analog Scale (VAS).
After the treatment, we observed significant improvements in both FIQ and VAS scores, indicating a notable positive effect of vitamin D on the quality of life and pain reduction in these patients. Particularly, the results suggested that many of the participants had a pre-existing vitamin D deficiency, which is more common among individuals with fibromyalgia.
Overall, this study highlights the potential benefits of vitamin D supplementation for those suffering from fibromyalgia and encourages further investigation into its role in managing this challenging condition.
After the treatment, we observed significant improvements in both FIQ and VAS scores, indicating a notable positive effect of vitamin D on the quality of life and pain reduction in these patients. Particularly, the results suggested that many of the participants had a pre-existing vitamin D deficiency, which is more common among individuals with fibromyalgia.
Overall, this study highlights the potential benefits of vitamin D supplementation for those suffering from fibromyalgia and encourages further investigation into its role in managing this challenging condition.
8.8
Strong bones benefit
Most Useful Review
Great! Vitamin D3 is essential. It's a high-quality product with great ingredients, easy to take with water. Since we often lack sunlight, this vitamin D3 quickly boosts my immunity. I recommend getting an exam to check for deficiency and repeating it after three months to observe improvements in bone strength and pain relief. I've been using this brand for two years, and I'm very satisfied, especially with my fibromyalgia.
Flu details
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.8
USERS' SCORE
Good
Based on 15 Reviews
8.7
8
Vitamin D reduces flu risk
Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials.
Most Relevant Research
We explored the potential benefits of vitamin D supplementation for reducing the risk of influenza infections. Through a comprehensive analysis of multiple Randomized Controlled Trials (RCTs), we aimed to clarify whether taking vitamin D can help prevent the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
9.5
Quick recovery
Most Useful Review
I took this for a cold/flu alongside vitamin C, NAC, omega-3, and zinc. The next day, I was back on my feet.
Hair Loss details
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8
USERS' SCORE
Good
Based on 26 Reviews
8.7
9
Vitamin D3 promotes hair growth
1,25-(OH)D promotes hair growth by inhibiting NLRP3/IL-1β and HIF-1α/IL-1β signaling pathways.
Most Relevant Research
This study dives into how 1,25-(OH)D, a potent form of vitamin D, influences hair growth. Through a combination of experiments in live mice, hair follicle organ culture, and detailed cellular investigations, we uncovered that this vitamin enhances hair regeneration.
Specifically, we found that 1,25-(OH)D not only extends the growth phase of hair follicles but also improves the abilities of certain skin cells that are vital for hair growth. This process relies on receptors for vitamin D, highlighting the importance of our body’s biological pathways in managing hair health.
Interestingly, our findings showed that 1,25-(OH)D can also negate some of the negative effects of DHT—a hormone often linked to hair loss. Overall, this suggests that vitamin D3 could be an effective treatment option for those experiencing androgenetic alopecia, or common hair loss.
Specifically, we found that 1,25-(OH)D not only extends the growth phase of hair follicles but also improves the abilities of certain skin cells that are vital for hair growth. This process relies on receptors for vitamin D, highlighting the importance of our body’s biological pathways in managing hair health.
Interestingly, our findings showed that 1,25-(OH)D can also negate some of the negative effects of DHT—a hormone often linked to hair loss. Overall, this suggests that vitamin D3 could be an effective treatment option for those experiencing androgenetic alopecia, or common hair loss.
8.8
Reduced hair loss
Most Useful Review
After four months of using the medication, my evaluation is quite positive. I took a pill once every two weeks, and my tests revealed excellent vitamin D levels. I experienced 100% hair loss initially, but this has now decreased by 50%. Furthermore, my joint pain has disappeared, and my memory issues no longer exist. The small pill is easy to swallow and does not cause stomach discomfort.
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.5
USERS' SCORE
Good
Based on 11 Reviews
8.6
8
Vitamin D deficiency linked to allergies
Does vitamin D deficiency predispose to allergic proctocolitis?
Most Relevant Research
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
9.5
Allergy relief
Most Useful Review
Although the rating is under trial, it suits me well. With all beef ingredients and no fish, it meets my allergy needs. The detailed ingredients, quality, and quantity are excellent, and I feel my immunity has improved.
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.8
USERS' SCORE
Good
Based on 4 Reviews
8.6
9
CYP11A1, Autism Symptoms, Vitamin D3
Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention.
Most Relevant Research
We explored how overexpression of the CYP11A1 enzyme in the placenta can impact offspring and potentially lead to autism-like behaviors, particularly focusing on anxiety. Using a specialized murine model, we looked closely at how this genetic change affected social interactions and anxiety levels in the mice.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
9.5
No more anxiety
Most Useful Review
I drink the Vitamin I once a week. There’s been a noticeable improvement; I sleep no more than eight hours and wake up without needing an alarm, feeling cheerful. My anxiety has decreased, and my mood is now stable. I'm very pleased and would like to take it more frequently, though I can't reach my doctor. I haven't experienced any side effects, and the tablet is easy to take.
Brain Tumor details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Vitamin D3 may reduce brain edema
Preoperative Serum Level of Vitamin D is a Possible Protective Factor for Peritumoral Brain Edema of Meningioma: A Cross Sectional Study.
Most Relevant Research
We investigated whether preoperative serum levels of vitamin D3 could influence peritumoral brain edema in patients diagnosed with meningioma. This study included 112 patients who underwent assessments of serum 25(OH)D levels and magnetic resonance imaging (MRI) to evaluate brain edema.
Our findings revealed a significant correlation between lower vitamin D3 levels and higher edema index (EI) percentages. Patients with EI below 100% had a median serum vitamin D3 level of 65.58 ng/mL, whereas those with EI above 100% had a much lower median of 37.33 ng/mL.
We found that for every increase of 1 ng/mL in serum vitamin D3, the extent of brain edema decreased by approximately 4%. This suggests that maintaining adequate levels of vitamin D3 may serve as a protective factor against peritumoral brain edema in patients with meningioma.
Our findings revealed a significant correlation between lower vitamin D3 levels and higher edema index (EI) percentages. Patients with EI below 100% had a median serum vitamin D3 level of 65.58 ng/mL, whereas those with EI above 100% had a much lower median of 37.33 ng/mL.
We found that for every increase of 1 ng/mL in serum vitamin D3, the extent of brain edema decreased by approximately 4%. This suggests that maintaining adequate levels of vitamin D3 may serve as a protective factor against peritumoral brain edema in patients with meningioma.
9.5
Improved vitamin D
Most Useful Review
Finally, a high-dose vitamin D supplement at a great price. The quality is superb since it's filled with virgin olive oil. I have a severe vitamin D deficiency, so this high dosage is essential. Remember to take it with vitamin K2 for optimal absorption; vitamin D is important for modulating immunity and has anti-tumour effects. Most people are vitamin D deficient.
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 23 Researches
8.2
USERS' SCORE
Good
Based on 9 Reviews
8.6
9
Vitamin D treatment reduces BPPV
Reduction of recurrence rate of benign paroxysmal positional vertigo by treatment of severe vitamin D deficiency.
Most Relevant Research
We sought to understand the impact of severe vitamin D deficiency on benign paroxysmal positional vertigo (BPPV), a common cause of dizziness. Previous studies showed a connection between low vitamin D levels and both the onset and recurrence of BPPV, but none had conclusively demonstrated that addressing this deficiency could lessen the recurrence of symptoms.
To examine this further, we included patients diagnosed with unilateral, idiopathic posterior canal BPPV and severe vitamin D deficiency, indicated by levels of 25-hydroxyvitamin D3 at or below 10 ng/ml. After thorough evaluations including hearing tests and balance assessments, we prescribed vitamin D therapy to our participants.
Over the following months, we monitored the changes in their vitamin D levels and followed up with them for 18 months to observe any recurrence of dizziness. Our findings revealed that patients who showed an improvement in their vitamin D levels experienced a significant reduction in the recurrence of BPPV symptoms.
This suggests that by addressing vitamin D deficiency, we can potentially offer a more effective approach to managing BPPV—lessening those troublesome dizzy spells that can really impact quality of life.
To examine this further, we included patients diagnosed with unilateral, idiopathic posterior canal BPPV and severe vitamin D deficiency, indicated by levels of 25-hydroxyvitamin D3 at or below 10 ng/ml. After thorough evaluations including hearing tests and balance assessments, we prescribed vitamin D therapy to our participants.
Over the following months, we monitored the changes in their vitamin D levels and followed up with them for 18 months to observe any recurrence of dizziness. Our findings revealed that patients who showed an improvement in their vitamin D levels experienced a significant reduction in the recurrence of BPPV symptoms.
This suggests that by addressing vitamin D deficiency, we can potentially offer a more effective approach to managing BPPV—lessening those troublesome dizzy spells that can really impact quality of life.
9.5
Dizziness relief
Most Useful Review
Hamdallah, I found relief from dizziness and fatigue after taking a weekly pill along with cod liver oil.
Eczema details
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.2
USERS' SCORE
Good
Based on 4 Reviews
8.6
8
Vitamin D reduces eczema severity
Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis.
Most Relevant Research
We focused on understanding the impact of vitamin D supplementation on atopic dermatitis, commonly known as eczema, in both children and adults. This systematic review analyzed data from eleven randomized controlled trials (RCTs), involving a total of 686 participants.
Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.
Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.
Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
9.5
Eczema improvement
Most Useful Review
This is the best D3 supplement I've found! It’s the only one on iHerb with such a high dose, and it has significantly improved my eczema, which is nearly gone!
Hashimoto details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.2
USERS' SCORE
Good
Based on 3 Reviews
8.6
4
Vitamin D3 shows limited effect
Alterations in CD4 T Cell Cytokines Profile in Female Patients with Hashimoto's Thyroiditis Following Vitamin D Supplementation: A Double-blind, Randomized Clinical Trial.
Most Relevant Research
We conducted a double-blind, randomized clinical trial to investigate how vitamin D3 supplementation affects Hashimoto's thyroiditis (HT) in female patients. Over three months, participants received either 50,000 IU of vitamin D3 or a placebo. Our focus was on measuring changes in serum cytokine levels and gene expression in CD4+ T cells, which play a critical role in the immune response associated with autoimmune diseases like HT.
Following vitamin D3 supplementation, we observed a significant increase in serum levels of 25-hydroxyvitamin D, while serum calcium levels also rose compared to where they started. However, when checking for changes related to immune response, we noted that supplementation led to a decrease in interleukin-17 (IL-17) levels, but this change didn't differ significantly from those in the placebo group.
On the other hand, the transforming growth factor-beta (TGFβ) gene expression rose significantly with vitamin D3 treatment, yet once again, we didn't see a noticeable difference between the two groups. Importantly, there was no marked effect on other key immune markers, such as interferon-gamma and IL-4 levels. Although we did see some increase in T-bet and GATA3 transcription factors, the overall impact of vitamin D3 on Hashimoto's thyroiditis in our study suggests limited benefits.
This trial sheds light on the complex relationship between vitamin D supplementation and autoimmune conditions like Hashimoto's thyroiditis. While vitamin D3 shows some promise, further long-term studies are essential to truly understand its role and effectiveness in managing HT.
Following vitamin D3 supplementation, we observed a significant increase in serum levels of 25-hydroxyvitamin D, while serum calcium levels also rose compared to where they started. However, when checking for changes related to immune response, we noted that supplementation led to a decrease in interleukin-17 (IL-17) levels, but this change didn't differ significantly from those in the placebo group.
On the other hand, the transforming growth factor-beta (TGFβ) gene expression rose significantly with vitamin D3 treatment, yet once again, we didn't see a noticeable difference between the two groups. Importantly, there was no marked effect on other key immune markers, such as interferon-gamma and IL-4 levels. Although we did see some increase in T-bet and GATA3 transcription factors, the overall impact of vitamin D3 on Hashimoto's thyroiditis in our study suggests limited benefits.
This trial sheds light on the complex relationship between vitamin D supplementation and autoimmune conditions like Hashimoto's thyroiditis. While vitamin D3 shows some promise, further long-term studies are essential to truly understand its role and effectiveness in managing HT.
9.5
Improves symptoms
Most Useful Review
This supplement is excellent for addressing my vitamin D deficiency. It supports my Hashimoto's hypothyroidism, and I've noticed numerous benefits. The good size, absorption, and flavourless quality make it a one-ingredient product of high quality that has significantly improved my symptoms.
Heart Disease details
SCIENTIFIC SCORE
Questionable
Based on 19 Researches
6.7
USERS' SCORE
Good
Based on 8 Reviews
8.6
7
Vitamin D's role in heart health
The Impact of Vitamin D Deficiency on Coronary Artery Disease Severity Based on Myocardial Perfusion Imaging: A Cross-Sectional Study.
Most Relevant Research
We examined how low levels of vitamin D (Vit D) could impact the severity of heart disease, specifically looking at myocardial ischemia. Our study involved two hundred patients who underwent myocardial perfusion imaging at Namazi Hospital in Shiraz, Iran, in 2019. We assessed both the severity of ischemia in patients and their vitamin D levels.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
9.5
Essential for bones
Most Useful Review
This is a high-quality and easily absorbed product, vital for immune diseases and bone health. It greatly increases calcium absorption but should be taken with vitamin K2. I recommend larger packs for duration, since those with heart disease need adequate Vitamin D3 for sustained periods.
Hypothyroidism details
SCIENTIFIC SCORE
Questionable
Based on 18 Researches
6.8
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Vitamin D improves thyroid function
Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis.
Most Relevant Research
We conducted a thorough exploration of how vitamin D supplementation can affect hypothyroidism, particularly in patients with Hashimoto's thyroiditis (HT). Our findings draw from a meta-analysis of twelve randomized controlled trials, involving a total of 862 participants. These studies compared the effects of vitamin D against placebo or no treatment, focusing on various thyroid function indicators and autoantibodies.
The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.
Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.
Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.
The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.
Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.
Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.
9.5
Improved symptoms
Most Useful Review
An excellent supplement for addressing deficiencies; it has greatly improved my symptoms related to Hashimoto's hypothyroidism. The quality is good, with proper absorption, and it's flavourless. Overall, I have noticed many benefits.
Insomnia details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.2
USERS' SCORE
Good
Based on 6 Reviews
8.6
8
Vitamin D benefits for insomnia
Efficacy of low-fat milk and yogurt fortified with encapsulated vitamin D on improvement in symptoms of insomnia and quality of life: Evidence from the SUVINA trial.
Most Relevant Research
We set out to explore the relationship between vitamin D and insomnia by examining how low-fat milk and yogurt fortified with 1,500 IU of nano-encapsulated vitamin D could improve sleep issues and overall quality of life.
In our analysis, we included adults with abdominal obesity and a history of insomnia, identifying twenty-nine participants through insomnia severity questionnaires. They were split into four groups: one receiving fortified low-fat milk, another with unfortified milk, a third group consuming fortified yogurt, and a fourth with unfortified yogurt. Over a ten-week period, we tracked changes in insomnia symptoms and quality of life.
Our findings revealed that those drinking the vitamin D fortified milk experienced significant improvements in insomnia scores compared to those consuming regular milk. Additionally, quality of life assessments showed positive changes for both fortified and unfortified milk groups. However, the yogurt groups did not demonstrate significant benefits, indicating that while fortified dairy has potential, yogurt may not be as effective in this context.
In conclusion, incorporating fortified low-fat milk into our diets could help ease insomnia symptoms and enhance life satisfaction, although yogurt did not show the same promise.
In our analysis, we included adults with abdominal obesity and a history of insomnia, identifying twenty-nine participants through insomnia severity questionnaires. They were split into four groups: one receiving fortified low-fat milk, another with unfortified milk, a third group consuming fortified yogurt, and a fourth with unfortified yogurt. Over a ten-week period, we tracked changes in insomnia symptoms and quality of life.
Our findings revealed that those drinking the vitamin D fortified milk experienced significant improvements in insomnia scores compared to those consuming regular milk. Additionally, quality of life assessments showed positive changes for both fortified and unfortified milk groups. However, the yogurt groups did not demonstrate significant benefits, indicating that while fortified dairy has potential, yogurt may not be as effective in this context.
In conclusion, incorporating fortified low-fat milk into our diets could help ease insomnia symptoms and enhance life satisfaction, although yogurt did not show the same promise.
9.5
Insomnia alleviation
Most Useful Review
Thank you. The quality is excellent with a large quantity. One pill per week over three months boosts immunity and combats depression. If suffering from insomnia, consider a vitamin D test; it might be deficient. Noticeable improvements came after the first pill, enhancing sleep and mood.
Menopause details
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.7
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin D supports bone health
Correlation between serum vitamin D levels and bone mass density evaluated by radiofrequency echographic multi-spectrometry technology (REMS) in menopausal women.
Most Relevant Research
We aimed to uncover the relationship between vitamin D levels and bone mineral density (BMD) in menopausal women, a group particularly vulnerable to osteoporosis due to hormonal changes. To achieve this, we conducted a thorough study involving 32 participants, all of whom were menopausal women without a history of hormone replacement therapy or vitamin D supplementation.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
9.5
Eliminated hot flashes
Most Useful Review
I took these vitamins to see how they would help with menopause, and I found them quite effective. The hot flashes diminished, and I appreciate their role alongside my mood-balancing vitamins. They truly work for menopause.
Obesity details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.6
8
Vitamin D reduces triglycerides effectively
Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials.
Most Relevant Research
We explored the effects of vitamin D supplementation on lipid profiles in overweight and obese women. Our investigation included data from various randomized controlled trials (RCTs) that specifically examined how vitamin D might influence cholesterol and triglyceride levels in this population.
Our analysis revealed that vitamin D had a significant impact on lowering triglycerides and total cholesterol levels. We found reductions of about 6.13 mg/dL for triglycerides and 4.45 mg/dL for total cholesterol. Additionally, there was a noteworthy increase in HDL cholesterol, the “good” cholesterol, by an average of 1.54 mg/dL.
Interestingly, we noticed that those with higher baseline triglyceride levels saw even greater benefits, particularly with a significant reduction in triglycerides when vitamin D was supplemented for 26 weeks or less. However, it’s important to mention that vitamin D supplementation did not have a significant effect on LDL cholesterol levels in this group.
Overall, our findings suggest that vitamin D can be an effective option for managing certain aspects of lipid profiles in overweight or obese women, particularly in addressing high triglycerides.
Our analysis revealed that vitamin D had a significant impact on lowering triglycerides and total cholesterol levels. We found reductions of about 6.13 mg/dL for triglycerides and 4.45 mg/dL for total cholesterol. Additionally, there was a noteworthy increase in HDL cholesterol, the “good” cholesterol, by an average of 1.54 mg/dL.
Interestingly, we noticed that those with higher baseline triglyceride levels saw even greater benefits, particularly with a significant reduction in triglycerides when vitamin D was supplemented for 26 weeks or less. However, it’s important to mention that vitamin D supplementation did not have a significant effect on LDL cholesterol levels in this group.
Overall, our findings suggest that vitamin D can be an effective option for managing certain aspects of lipid profiles in overweight or obese women, particularly in addressing high triglycerides.
9.5
Essential for health
Most Useful Review
Very useful! I cannot do without vitamin D. I highly recommend it for those suffering from unexplained obesity, fatigue, lethargy, and weak muscles and bones.
Tonsillitis details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin D may reduce tonsillitis
Vitamin D Levels in Children with Recurrent Acute Tonsillitis in Jordan: A Case-Control Study.
Most Relevant Research
We aimed to understand the link between vitamin D deficiency and recurrent acute tonsillitis in children. In our study, we gathered data from 242 children suffering from repeated bouts of tonsillitis and compared it with a control group of 262 healthy children.
Our findings revealed that the average vitamin D levels were significantly lower in those with recurrent tonsillitis. Through detailed statistical analysis, we discovered that as vitamin D levels increased, the number of tonsillitis episodes decreased. Specifically, for every increase of one unit in vitamin D, we saw a 3.1% reduction in occurrences of tonsillitis each year.
These results strongly suggest that vitamin D deficiency may contribute to more frequent episodes of tonsillitis in children. To further enhance our understanding, we recommend future trials to explore the potential benefits of vitamin D supplementation for those frequently affected by this condition.
Our findings revealed that the average vitamin D levels were significantly lower in those with recurrent tonsillitis. Through detailed statistical analysis, we discovered that as vitamin D levels increased, the number of tonsillitis episodes decreased. Specifically, for every increase of one unit in vitamin D, we saw a 3.1% reduction in occurrences of tonsillitis each year.
These results strongly suggest that vitamin D deficiency may contribute to more frequent episodes of tonsillitis in children. To further enhance our understanding, we recommend future trials to explore the potential benefits of vitamin D supplementation for those frequently affected by this condition.
8.8
Effective remedy
Most Useful Review
Super!!! During a bout of chronic tonsillitis in another country without access to medication, this remedy was my salvation! The capsule sizes are average, and the quality along with the ingredients is excellent. It truly works! I placed the herb directly on the root of my tongue and allowed it to dissolve slowly—it has saved me on more than one occasion!
Back Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.6
USERS' SCORE
Good
Based on 10 Reviews
8.5
9
Vitamin D3 improves back pain
Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial.
Most Relevant Research
We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
9
Manageable back pain
Most Useful Review
Definitely works! My wife and I wanted to boost our D levels and paired this brand with Life Extensions Super K. After two weeks, my wife's D level improved significantly, and we adjusted her dosage. I've also noticed a significant improvement in my osteoarthritis pain in my lower back and hips, and I've reduced my NSAID intake drastically.
Blurred Vision details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Improves vision clarity
Most Useful Review
Best quality. I am using the maximum dosage and am very pleased with it. The packaging is excellent, and the capsules are in liquid form, indicating a high-quality and effective product. It enhances immunity and aids in restoring my vision.
Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.5
USERS' SCORE
Good
Based on 7 Reviews
8.5
8
Vitamin D3 offers anti-cancer benefits
Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth.
Most Relevant Research
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
9.5
Benefits cancer patients
Most Useful Review
This is the best vitamin D3 I prescribe for my cancer patients. It's vital for those diagnosed with cancer. I usually recommend one capsule per week, or sometimes one daily for cancer patients, as it rapidly raises serum calcidiol levels and is safe with regular lab tests.
Diabetes details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
USERS' SCORE
Good
Based on 9 Reviews
8.5
2
Vitamin D3 shows no diabetes benefit
The effect of vitamin D supplementation on the incidence of type 2 diabetes in healthy older adults not at high risk for diabetes (FIND): a randomised controlled trial.
Most Relevant Research
We conducted a thorough investigation to understand how vitamin D3 supplementation influences the risk of developing type 2 diabetes in healthy older adults. Over the course of five years, we carried out a randomized, placebo-controlled trial involving 2,271 participants aged 60 and over. This diverse group of adults was free from cardiovascular disease and cancer, ensuring a focus on individuals not at high risk for diabetes.
Our study involved three groups: one receiving a placebo, another taking 1600 IU of vitamin D3 daily, and a third consuming 3200 IU daily. Remarkably, neither dosage of vitamin D3 showed a significant reduction in the risk of developing diabetes during our observations. Throughout the trial, we utilized national health registries to track the occurrence of diabetes, while a subgroup of participants underwent more detailed health assessments at various points.
Overall, despite the promising discussions around vitamin D and its health benefits, our findings indicate that vitamin D3 supplementation doesn't significantly lower diabetes risk in older adults who already have adequate vitamin D levels for maintaining bone health. This intriguing outcome adds valuable insight into the ongoing conversation about vitamin D's role in diabetes prevention.
Our study involved three groups: one receiving a placebo, another taking 1600 IU of vitamin D3 daily, and a third consuming 3200 IU daily. Remarkably, neither dosage of vitamin D3 showed a significant reduction in the risk of developing diabetes during our observations. Throughout the trial, we utilized national health registries to track the occurrence of diabetes, while a subgroup of participants underwent more detailed health assessments at various points.
Overall, despite the promising discussions around vitamin D and its health benefits, our findings indicate that vitamin D3 supplementation doesn't significantly lower diabetes risk in older adults who already have adequate vitamin D levels for maintaining bone health. This intriguing outcome adds valuable insight into the ongoing conversation about vitamin D's role in diabetes prevention.
8.8
Increases immunity
Most Useful Review
Excellent dosage of Vitamin D! Those wishing to maintain their vitamin D levels can take 1 capsule weekly. For those with an acute deficiency like mine, it’s better to take every other day. I’m ordering again for my whole family! Correct consumption of vitamin D strengthens bones, improves blood composition, alleviates dry hair and skin, reduces the risk of oncology and diabetes, enhances immunity, and boosts concentration. Highly recommend it for good health!
Liver Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.5
9
Vitamin D improves liver health
Effects of vitamin D supplementation on the glycaemic indices, lipid profile and liver function tests in patients with cirrhosis: a double-blind randomised controlled trial.
Most Relevant Research
We explored the effects of vitamin D supplementation in patients with liver cirrhosis—a progressive disease that often manifests alongside vitamin D deficiency. In a carefully designed study, we involved sixty patients who participated in a double-blind, randomized controlled trial. Each patient received either a weekly dose of 50,000 IU of vitamin D or a placebo over 12 weeks.
Throughout the study, we assessed key health markers before and after supplementation, including liver function tests, lipid profiles, and glycaemic indices such as fasting blood glucose and insulin resistance. By the end of the trial, our findings indicated that vitamin D supplementation significantly improved fasting blood glucose levels and insulin resistance in the participants.
Specifically, we observed noteworthy increases in serum 25-hydroxy-vitamin D levels and reductions in fasting blood glucose and insulin resistance indicators. These results suggest that vitamin D might be an important player in improving metabolic health for those suffering from liver cirrhosis.
Throughout the study, we assessed key health markers before and after supplementation, including liver function tests, lipid profiles, and glycaemic indices such as fasting blood glucose and insulin resistance. By the end of the trial, our findings indicated that vitamin D supplementation significantly improved fasting blood glucose levels and insulin resistance in the participants.
Specifically, we observed noteworthy increases in serum 25-hydroxy-vitamin D levels and reductions in fasting blood glucose and insulin resistance indicators. These results suggest that vitamin D might be an important player in improving metabolic health for those suffering from liver cirrhosis.
8.3
Self-medication warning
Most Useful Review
Thank you for Vitamin D! For three years, I've adhered to a protocol using high-dose Vitamin D for my liver disease, which previously necessitated cortisone and strong medications. I'm now completely off those. However, I advise caution against self-medication and stress the importance of medical supervision. This brand is the best available, and I highly recommend it.
Osteoporosis details
SCIENTIFIC SCORE
Moderately Effective
Based on 24 Researches
8
USERS' SCORE
Good
Based on 13 Reviews
8.5
8
Vitamin D's impact on osteoporosis
The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis.
Most Relevant Research
We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
9.5
Increases calcium absorption
Most Useful Review
It's important to take one capsule weekly with a fatty meal. Vitamin D aids in calcium absorption, promoting bone strength and preventing osteoporosis. The quality is superb, and it boosts immunity. There’s no taste.
Whooping Cough details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.5
9.5
Effective treatment
Most Useful Review
I always trust NOW brand for quality. I need a high-dose vitamin D, and most options are in powdered or capsule form. I was delighted to find the gel caps. I take them with food for better absorption, and the oil content reassures me it's being absorbed. After suffering from whooping cough in 2020, I finally recovered after taking high doses of vitamin D and C. I'm grateful for the quality supplements during dire times. I highly recommend this product.
Constipation details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 5 Reviews
8.4
7
Vitamin D3's impact on constipation inconclusive
Effectiveness of the Combination of Probiotic Supplementation on Motor Symptoms and Constipation in Parkinson's Disease.
Most Relevant Research
We explored the effects of probiotic supplementation combined with vitamin D3 on constipation and motor symptoms in individuals with Parkinson's disease. This study focused on a group of patients who had chronic constipation and used a specific probiotic formula.
Over the course of three months, we evaluated 32 patients to see if the supplementation made a difference in their digestive health and overall symptoms. We carefully monitored factors like bowel habits and employed various assessments to track the subjects' progress.
While our findings indicated some benefits from the probiotic intervention, the specific impact of vitamin D3 alone on constipation remains unclear due to the combination with probiotics in our approach. Therefore, we cannot draw definitive conclusions about the effectiveness of vitamin D3 by itself in alleviating constipation. Our research does suggest that the gut microbiome plays a role in managing symptoms associated with Parkinson's disease, emphasizing the importance of ongoing investigations in this field.
Over the course of three months, we evaluated 32 patients to see if the supplementation made a difference in their digestive health and overall symptoms. We carefully monitored factors like bowel habits and employed various assessments to track the subjects' progress.
While our findings indicated some benefits from the probiotic intervention, the specific impact of vitamin D3 alone on constipation remains unclear due to the combination with probiotics in our approach. Therefore, we cannot draw definitive conclusions about the effectiveness of vitamin D3 by itself in alleviating constipation. Our research does suggest that the gut microbiome plays a role in managing symptoms associated with Parkinson's disease, emphasizing the importance of ongoing investigations in this field.
9.5
Helps with constipation
Most Useful Review
These vitamins have restored my hair health and benefit my bones. Calcium's advantages are well-known, but its absorption relies on vitamin D3. Magnesium, crucial for heart health, normalises blood pressure and aids in relieving constipation, making it suitable even for pregnant women.
Knee Pain details
SCIENTIFIC SCORE
Questionable
Based on 29 Researches
6.9
USERS' SCORE
Good
Based on 5 Reviews
8.4
8
Vitamin D3 shows promise for knee OA
The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis.
Most Relevant Research
We explored the potential benefits of vitamin D3 supplementation in alleviating knee pain associated with osteoarthritis (OA). In this open-label clinical trial, we assessed the effects of daily doses of 4000 IU vitamin D3 over three months in 80 patients suffering from knee OA.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
9.5
Pain relief noted
Most Useful Review
A magical product. One pill effectively alleviates back and leg pain, yet follow-up is necessary. Excellent quality and wonderful ingredients at a good price. The dosage is one pill weekly.
Pelvic Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.4
9.5
Relief from pain
Most Useful Review
A product like magic. One pill alleviates back and pelvic pain, though follow-up is essential. Excellent quality and wonderful ingredients. Great quantity for the price, with a dosage of one pill weekly.
Kidney Stones details
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
5
USERS' SCORE
Good
Based on 7 Reviews
8.3
4
Vitamin D's limited effect on kidney stones
Effect of two vitamin D repletion protocols on 24-h urine calcium in patients with recurrent calcium kidney stones and vitamin D deficiency: a randomized clinical trial.
Most Relevant Research
We conducted a clinical trial to explore how different vitamin D treatment protocols affect kidney stones in patients who frequently experience them and have low vitamin D levels. We involved 62 participants, all with serum vitamin D levels between 10 to 20 ng/ml, and split them into two groups: one received 2000 IU of oral vitamin D daily for 12 weeks, while the other took 50,000 IU weekly for 8 weeks.
Our results showed that both treatment approaches led to a significant increase in 24-hour urine calcium. However, we observed no notable difference between the two therapies regarding this measure. Importantly, while there was an increase in 24-hour urine calcium, neither treatment affected the supersaturation levels of calcium oxalate or calcium phosphate, which are critical in the formation of kidney stones.
We also noted a significant rise in serum 25-hydroxyvitamin D levels, with the weekly regimen showing a greater increase. Alongside these changes, parathyroid hormone levels decreased in both groups. Ultimately, while vitamin D supplementation did elevate urine calcium levels, it did not enhance supersaturation factors that contribute to kidney stone formation, indicating that the benefits of vitamin D in this context may be limited.
Our results showed that both treatment approaches led to a significant increase in 24-hour urine calcium. However, we observed no notable difference between the two therapies regarding this measure. Importantly, while there was an increase in 24-hour urine calcium, neither treatment affected the supersaturation levels of calcium oxalate or calcium phosphate, which are critical in the formation of kidney stones.
We also noted a significant rise in serum 25-hydroxyvitamin D levels, with the weekly regimen showing a greater increase. Alongside these changes, parathyroid hormone levels decreased in both groups. Ultimately, while vitamin D supplementation did elevate urine calcium levels, it did not enhance supersaturation factors that contribute to kidney stone formation, indicating that the benefits of vitamin D in this context may be limited.
9.5
High dosage recommendation
Most Useful Review
This product is excellent for its strength of 50,000 units per week. One pill is sufficient, and its oily texture seems better for kidney health.
Prostate Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.2
8
Vitamin D may reduce prostate cancer mortality
Intratumoral vitamin D signaling and lethal prostate cancer.
Most Relevant Research
We set out to understand how vitamin D signaling within prostate cancer tumors might impact patient outcomes, particularly the risk of developing lethal forms of the disease. In our exploration, we analyzed data from 404 men with primary prostate cancer over a long follow-up period, assessing specific gene expressions linked to vitamin D in their tumor tissues.
Our findings revealed a noteworthy trend: the activation of vitamin D signaling in tumors was associated with a lower chance of progressing to lethal prostate cancer. Specifically, men with higher scores indicating active vitamin D signaling had a significantly reduced risk of metastasis or prostate cancer-related death compared to those with lower scores.
Interestingly, this protective association appeared to be stronger in individuals with predicted higher levels of vitamin D in their blood and those who had a body mass index of 25 or higher. With our research providing a clearer picture of how vitamin D functions within tumors, we believe there’s a solid basis for considering vitamin D interventions as potential strategies to enhance survival outcomes for prostate cancer patients.
Our findings revealed a noteworthy trend: the activation of vitamin D signaling in tumors was associated with a lower chance of progressing to lethal prostate cancer. Specifically, men with higher scores indicating active vitamin D signaling had a significantly reduced risk of metastasis or prostate cancer-related death compared to those with lower scores.
Interestingly, this protective association appeared to be stronger in individuals with predicted higher levels of vitamin D in their blood and those who had a body mass index of 25 or higher. With our research providing a clearer picture of how vitamin D functions within tumors, we believe there’s a solid basis for considering vitamin D interventions as potential strategies to enhance survival outcomes for prostate cancer patients.
8.8
Treatment efficacy
Most Useful Review
This vitamin D3 from Now Foods is excellent. I prescribe 50,000 IU to my cancer patients, particularly those with prostate cancer. It's crucial for managing the condition. Typically, I recommend one capsule weekly, but for prostate cancer patients, I sometimes suggest daily doses. The serul calcidiol levels increase quickly and it's safe, thanks to regular lab tests.
Psoriasis details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.4
USERS' SCORE
Good
Based on 8 Reviews
8.2
9.5
Vitamin D3 ethosomes for psoriasis
Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies.
Most Relevant Research
We aimed to explore the effectiveness of a special gel infused with vitamin D3, known as an ethosome, in managing psoriasis. This inflammatory skin condition is driven by an overactive immune response, and vitamin D3 plays a crucial role in the growth and development of skin cells called keratinocytes, making it a promising treatment option.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
9.5
Effective for psoriasis
Most Useful Review
Good quality, perfect packaging, and great for skin diseases. I've noticed a significant improvement in my psoriasis and my immunity has also benefited. It has no smell!
Sleep Apnea details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.1
USERS' SCORE
Good
Based on 5 Reviews
8.1
9
Vitamin D3 improves mild sleep apnea
The effects of vitamin D supplemantation on prognosis in patients with mild obstructive sleep apnea syndrome.
Most Relevant Research
We set out to evaluate what effect vitamin D3 supplementation might have on patients suffering from mild obstructive sleep apnea syndrome (OSAS). In this study, 19 adult men who were diagnosed with mild OSAS and had low vitamin D levels participated over an 8-week period. Each week, they took a sizable dose of 50,000 IU of vitamin D3 while undergoing various health assessments. We measured important factors like blood glucose, lipid profiles, and inflammation markers, along with repeated sleep monitoring through polysomnography.
By the end of the study, we observed a significant increase in participants' vitamin D levels, which jumped from an average of 19.5 to 41.8 ng/mL—an indication that the supplementation was effective. Along with this rise in vitamin D, we also noted improvements in fasting blood glucose and total cholesterol levels, as well as a decrease in key inflammation markers. Most encouragingly, the frequency of obstructive apneas and other related sleep disturbances significantly decreased.
Based on these findings, it seems that vitamin D supplementation can play a beneficial role in improving the prognosis for those with mild OSAS. It's exciting to consider how something as simple as a vitamin could lead to better sleep health for individuals struggling with sleep apnea.
By the end of the study, we observed a significant increase in participants' vitamin D levels, which jumped from an average of 19.5 to 41.8 ng/mL—an indication that the supplementation was effective. Along with this rise in vitamin D, we also noted improvements in fasting blood glucose and total cholesterol levels, as well as a decrease in key inflammation markers. Most encouragingly, the frequency of obstructive apneas and other related sleep disturbances significantly decreased.
Based on these findings, it seems that vitamin D supplementation can play a beneficial role in improving the prognosis for those with mild OSAS. It's exciting to consider how something as simple as a vitamin could lead to better sleep health for individuals struggling with sleep apnea.
9.5
Improved sleep apnea
Most Useful Review
Works excellently! After taking a high dose for a month and a half alongside magnesium, zinc, and K2, my vitamin D levels increased significantly. When I paused for two weeks, my sleep apnea returned, but resumed use eliminated the symptoms. I no longer experience choking or tongue-biting.
Acne details
SCIENTIFIC SCORE
Questionable
Based on 24 Researches
6.8
USERS' SCORE
Good
Based on 6 Reviews
8
8
Vitamin D's effect on acne
Association between Vitamin D Level and Acne, and Correlation with Disease Severity: A Meta-Analysis.
Most Relevant Research
We examined how vitamin D levels relate to acne and the potential connection with acne severity. By analyzing data from various studies, we found that 1,362 individuals with acne were compared against 1,081 healthy controls.
Our findings revealed that those with acne had significantly lower vitamin D levels compared to the healthy participants. Additionally, vitamin D deficiency was more prevalent among acne sufferers. Interestingly, we also observed a negative correlation between vitamin D levels and acne severity, suggesting that lower levels of this vitamin might be associated with more severe acne.
This evidence points to the possibility that vitamin D plays a role in acne development. However, while our results are compelling, they encourage further investigation into how vitamin D might influence acne severity and whether its supplementation could be beneficial for those affected by this condition.
Our findings revealed that those with acne had significantly lower vitamin D levels compared to the healthy participants. Additionally, vitamin D deficiency was more prevalent among acne sufferers. Interestingly, we also observed a negative correlation between vitamin D levels and acne severity, suggesting that lower levels of this vitamin might be associated with more severe acne.
This evidence points to the possibility that vitamin D plays a role in acne development. However, while our results are compelling, they encourage further investigation into how vitamin D might influence acne severity and whether its supplementation could be beneficial for those affected by this condition.
9.5
Acne relief
Most Useful Review
These excellent quality Vitamin D3 tablets positively impacted my skin, helping me to clear my acne. With limited sunlight in winter, this vitamin is crucial. The packaging is good too.
Chest Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.6
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.9
8
Vitamin D deficiency affects symptoms
The Association Between Vitamin D Level and Chest Pain, Anxiety, and Fatigue in Patients With Coronary Artery Disease.
Most Relevant Research
We aimed to understand how vitamin D deficiency (VDD) might influence symptoms like chest pain, anxiety, and fatigue in people living with coronary artery disease (CAD). In our investigation, we collected data from 90 CAD patients, focusing on their vitamin D levels and experiences with these symptoms.
The findings were quite revealing. A significant 80% of the participants were found to have low vitamin D levels. Interestingly, we discovered that lower vitamin D levels were linked to increased chest pain and heightened anxiety and fatigue. Specifically, there were strong negative relationships noted: as vitamin D levels dropped, chest pain, anxiety, and fatigue scores rose.
This suggests that addressing vitamin D deficiency might be an important step for managing cardiac-related symptoms in patients with CAD. As this connection unfolds, it seems valuable for healthcare providers to monitor vitamin D levels in CAD patients and consider interventions to correct deficiencies.
The findings were quite revealing. A significant 80% of the participants were found to have low vitamin D levels. Interestingly, we discovered that lower vitamin D levels were linked to increased chest pain and heightened anxiety and fatigue. Specifically, there were strong negative relationships noted: as vitamin D levels dropped, chest pain, anxiety, and fatigue scores rose.
This suggests that addressing vitamin D deficiency might be an important step for managing cardiac-related symptoms in patients with CAD. As this connection unfolds, it seems valuable for healthcare providers to monitor vitamin D levels in CAD patients and consider interventions to correct deficiencies.
9.5
Pain relief noted
Most Useful Review
I had pain in my lower back and legs, which I later realised was due to vitamin D deficiency. After taking the supplement, the pain disappeared.
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.7
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
9
Vitamin D3 aids migraine relief
Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial.
Most Relevant Research
We conducted a rigorous study to explore how vitamin D3 supplementation might influence headaches in people suffering from migraines. By utilizing a well-structured, placebo-controlled, double-blind design, we included 80 participants with episodic migraines, assigning them either a daily dose of vitamin D3 or a placebo for 12 weeks.
After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.
Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.
After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.
Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.
9.5
Immediate relief
Most Useful Review
The quality is excellent with natural ingredients. It helped straight away; my headache ceased almost instantly.
Nausea details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.5
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.9
8
Vitamin D and nausea in gastroparesis
Low Vitamin D Levels in Patients with Symptoms of Gastroparesis: Relationships with Nausea and Vomiting, Gastric Emptying and Gastric Myoelectrical Activity.
Most Relevant Research
We delved into an intriguing question: how do low vitamin D levels affect nausea in people experiencing gastroparesis, a condition that slows gastric emptying? By measuring the vitamin D levels of patients from the Gastroparesis Clinical Consortium Registry, we aimed to uncover the relationships between vitamin D, nausea, and gastric function.
Our findings revealed that over half of the patients had low vitamin D levels, specifically 56.1% of the 513 individuals studied. We observed a clear association between these low levels of vitamin D and increased experiences of nausea and vomiting. This was particularly notable in patients with delayed gastric emptying, where those with low vitamin D levels reported significantly more nausea.
While the study showed a correlation, it did not address whether supplementing with vitamin D could directly alleviate these symptoms. Instead, we found that lower vitamin D levels also related to a greater retention of food in the stomach after meals, which hints at a connection to gastric neuromuscular dysfunction. Overall, our study emphasized a noteworthy link between vitamin D and nausea but stopped short of confirming any direct treatment benefits.
Our findings revealed that over half of the patients had low vitamin D levels, specifically 56.1% of the 513 individuals studied. We observed a clear association between these low levels of vitamin D and increased experiences of nausea and vomiting. This was particularly notable in patients with delayed gastric emptying, where those with low vitamin D levels reported significantly more nausea.
While the study showed a correlation, it did not address whether supplementing with vitamin D could directly alleviate these symptoms. Instead, we found that lower vitamin D levels also related to a greater retention of food in the stomach after meals, which hints at a connection to gastric neuromuscular dysfunction. Overall, our study emphasized a noteworthy link between vitamin D and nausea but stopped short of confirming any direct treatment benefits.
9.5
Improved sleep
Most Useful Review
Buying this product a second time, I find it genuine and it doesn't cause any nausea or side effects like other vitamins. My husband had a deficiency and felt weak and tired. After four months of taking it weekly, his sleep improved and he feels stronger. It's essential to determine the best time to take it; he felt sleepy during the day when taken in the morning as advised by the doctor.
Heart Attack details
SCIENTIFIC SCORE
Questionable
Based on 24 Researches
6.6
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.8
9
Calcitriol aids heart recovery
Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction.
Most Relevant Research
We examined the impact of calcitriol, the active form of vitamin D, on heart attack recovery using a mouse model of myocardial infarction (MI). In our study, we treated mice that had suffered a MI with calcitriol and observed promising results.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
7.5
Reduced heart disease
Most Useful Review
D3 can aid in weight loss and lower the risk of rheumatoid arthritis and blood pressure. Additionally, it might decrease the risk of heart disease.
