We evaluated the effectiveness of vitamin K antagonists (VKAs) in treating left ventricular thrombosis (LVT). Over a year, a cohort of 90 patients was observed for LVT resolution and complications.

By the end of the study, approximately 70% of participants saw their blood clots resolve, with lower success rates linked to factors like reduced heart function. While VKAs showed promise, the treatment's safety profile was also notable, with few severe complications reported.

Normal clotting restored

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478 people found this helpful

A friend experienced poor blood clotting and was prescribed these vitamins. After two months of use, everything has returned to normal.

Updated: Mar 2026

Liver Disease details

46 people found this helpful

I took vitamin K2 following a body cleanse with Triphala. After two weeks, I experienced severe pain in my upper abdomen and struggled to sleep or sit. My dyskinesia made it worse. Remembering that K2 aids in liver disease recovery, I tried it. After taking it, the pain vanished and I slept well. I also noticed that my friend with stomach issues benefited from it, as it helped alleviate her pain too. I believe this vitamin is essential not just for bones but also for gastrointestinal health.

Updated: Apr 2025

Osteoporosis details

SCIENTIFIC SCORE

Possibly Effective

Based on 24 Researches

Vitamin K2 supports BMD in osteoporosis

Zhou M, Han S, Zhang W, Wu D. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review. J Bone Miner Metab. 2022;40:763. doi:10.1007/s00774-022-01342-6

To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.

The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.

While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis.

Improves bone density

Most Useful Review

301 people found this helpful

I have found the combination of Strontium, D3, and K2 to be beneficial. Research supports that K2 aids in improving bone density, especially crucial after developing osteoporosis. This product has dramatically increased my bone density and significantly reduced my risk of hip fractures, making me feel hopeful about my bone health as I once thought I had osteoporosis but may now be normal.

Updated: Mar 2026

Cardiovascular Disease details

SCIENTIFIC SCORE

Possibly Effective

Based on 5 Researches

Vitamin K assists in thrombosis resolution

We examined the effectiveness and safety of vitamin K antagonists (VKAs) in resolving left ventricular thrombosis in a group of 90 patients over 12 months.

While we found that 70% experienced resolution of the thrombosis by the end of the study, the presence of low left ventricular ejection fraction and aneurysms negatively impacted outcomes.

Overall, the rate of complications, including strokes and major bleeding, remained low during the treatment period, indicating that VKAs can be a viable option, though some patients may face challenges in resolution.

Essential for health

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1 people found this helpful

As someone with a family history of cardiovascular disease, I find K-2 vital for my health and fitness regimen at 76 years old. It is an essential part of my nutrition and workout programme, helping maintain my outstanding health.

Updated: Mar 2026

Allergies details

Effective for rhinitis

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8 people found this helpful

I am undergoing megavitamin therapy. My husband suffers from hay fever, and I have severe allergies to rhinitis, so I commenced taking vitamin D3 at 30,000 IU. A dose of 100mcg of vitamin K2 is necessary for every 10,000 IU of vitamin D3, hence they are combined. Although some preparations contain both D3 and K2, I find it a bit expensive, so I appreciate being able to purchase them separately. My nose often feels blockaged before bedtime, but now it is completely clear. Thank you.

Updated: Apr 2025

Autoimmune Disorder details

SCIENTIFIC SCORE

Possibly Effective

Based on 3 Researches

Vitamin K-dependent GAS6 enhances remyelination

Asadian N, Aprico A, Chen M, Yuen D, Johnston APR, et al. The therapeutic effect of GAS6 in remyelination is dependent upon Tyro3. Glia. 2024;72:1392. doi:10.1002/glia.24534

We investigated the role of GAS6 in promoting remyelination, particularly in relation to vitamin K's effect on a type of receptor.

Our findings highlight that GAS6 needs to be modified through vitamin K for proper function.

When introduced to wild-type mice, this treatment significantly increased the number of myelinated axons compared to a control group.

However, in mice lacking the specific Tyro3 receptor, no significant improvement was noted. This indicates that Tyro3 is crucial for the effectiveness of GAS6 in aiding recovery for conditions like multiple sclerosis.

Improved vitamin levels

Most Useful Review

1 people found this helpful

Just what I needed! Since I began taking K2, my vitamin D levels have risen into the normal range. I previously took vitamin D alone for a year with no changes. After adding K2, my levels increased over 100 points within three months! I found the mk7 version caused anxiety and insomnia, so I switched to mk4 without any negative side effects. I'm very pleased with this product and will order it again.

Updated: Mar 2026

Knee Pain details

Vitamin K may reduce knee pain

Liao Z, Chang J, Zhu Z, Han W, Meng T, et al. Associations Between Dietary Intake of Vitamin K and Changes in Symptomatic and Structural Changes in Patients With Knee Osteoarthritis. Arthritis Care Res (Hoboken). 2023;75:1503. doi:10.1002/acr.24964

We explored the link between dietary vitamin K intake and knee pain in patients suffering from osteoarthritis. Over two years, we followed 259 participants, measuring their vitamin K intake and knee symptoms using established assessment tools.

Our findings revealed that higher vitamin K intake was associated with a noticeable reduction in knee pain. For those with severe pain at the beginning, the benefits were even clearer. However, we did not find significant impacts on knee structure based on MRI scans.

This suggests that further trials on vitamin K supplementation for knee pain may be valuable, especially for those experiencing severe symptoms.

Discomfort vanished

Most Useful Review

1 people found this helpful

A good choice for vitamin K2, especially when taken with D3. I work on my feet and began feeling discomfort in my knees, but after two months of use, that discomfort has completely disappeared. I would highly recommend it.

Updated: Mar 2026

Stroke details

Supports post-stroke recovery

Most Useful Review

This is an effective product for supporting blood coagulation and promoting cardiovascular health. It's particularly beneficial for individuals who have experienced strokes.

Updated: Mar 2026

Back Pain details

Vitamin K2 boosts back pain recovery

Zhang W, Li L, Zhou X, Li K, Liu C, et al. Concurrent Treatment with Vitamin K2 and D3 on Spine Fusion in Patients with Osteoporosis-Associated Lumbar Degenerative Disorders. Spine (Phila Pa 1976). 2022;47:352. doi:10.1097/BRS.0000000000004309

We explored how treating patients with osteoporosis with vitamin K2 and D3 could influence back pain and spine fusion rates following surgery. In this study, we included patients who underwent spinal surgery for lumbar degenerative disorders. Some received a combination of vitamin K2, D3, and calcium, while others were treated with only calcium and vitamin D3.

The results showed that those who took vitamin K2 along with their other treatments had improved fusion rates and experienced less back pain. Furthermore, clinical symptoms improved, and there was a marked promotion of bone health within six months after surgery. Notably, the administration of vitamin K2 also helped maintain bone mineral density.

Overall, this research suggests that incorporating vitamin K2 alongside traditional treatments could be beneficial for individuals dealing with back pain related to osteoporosis. It opens the door for more studies on how we might better treat and manage spinal conditions in these patients.

7.5

Reduced back pain

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42 people found this helpful

This K2-D3 combination is excellent for bones, cartilage, and sciatica. Despite a recommendation for knee replacement due to my pain, after using K2-D3, my sciatica is hardly noticeable, and my knees feel better. I plan to check for cartilage improvement soon!

Updated: Mar 2026

Bruise details

SCIENTIFIC SCORE

Moderately Effective

Based on 7 Researches

Infant bruising due to deficiency

Palau MA, Winters A, Liang X, Nuss R, Niermeyer S, et al. Vitamin K Deficiency Presenting in an Infant with an Anterior Mediastinal Mass: A Case Report and Review of the Literature. Case Rep Pediatr. 2017;2017:7628946. doi:10.1155/2017/7628946

We observed an interesting case involving a 1-month-old infant with significant bruising and severe vitamin K deficiency. This deficiency led to spontaneous thymic hemorrhage, which was identified along with coagulopathy during medical evaluation.

The child had not received vitamin K prophylaxis at birth, which likely contributed to the outcomes we saw. Fortunately, after administering vitamin K, the coagulopathy improved. This case highlights the essential role of vitamin K in preventing serious bleeding issues in infants.

Stable bruising prevention

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7 people found this helpful

Since my tonsillectomy 30 years ago, I've had a tendency to bleed and bruise easily. I’ve discovered that taking Vitamin K has significantly helped manage this issue. The K-2 formula seems particularly effective for me. I’ve taken it for most of my life, and it truly makes a difference in preventing excessive bruising and bleeding when injured. This is the best product I’ve used.

Updated: Mar 2026

Heart Attack details

SCIENTIFIC SCORE

Possibly Effective

Based on 9 Researches

Menaquinone-4 aids heart recovery

Hassan AE, Hadhoud S, Elmahdi E, Elkattawy HA. Potential Cardioprotective Role of Menaquinone-4 Against Cardiac Ischemia-reperfusion Injury. J Cardiovasc Pharmacol. 2023;81:381. doi:10.1097/FJC.0000000000001413

We examined how Menaquinone-4, a form of vitamin K2, could help protect the heart during a critical event known as ischemia-reperfusion (I/R) injury, which often occurs after heart attacks. In our study, we used thirty-two rats, dividing them into three groups: a control group that experienced I/R without treatment, a group that received MK-4 before the injury, and another group that got MK-4 at the beginning of the recovery phase.

By using a specialized apparatus to assess heart function, we measured various indicators of heart health, including the pressure the heart could generate and rates of heart contractions. We also examined markers of heart damage and stress, like enzymes and inflammatory signals.

Our findings were promising. The group that received MK-4 after the I/R injury showed a significant reduction in the size of heart damage, alongside improved heart function. This group also had lower levels of markers related to heart stress and damage, indicating that MK-4 might help the heart recover from the stress of a heart attack. Overall, these results suggest that vitamin K2 could be a valuable ally in enhancing heart health during recovery from ischemic events.

Improved artery health

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44 people found this helpful

It works for dental health. After having a heart attack in February 2018 with significant artery blockages, I adopted a strict plant-based diet for eight months and took four pills of this product and two of vitamin D3 daily. A recent calcium scoring CT scan revealed that my left artery plaque has reduced to moderate, with the other arteries clear of plaque. Praise the Lord.

Updated: Apr 2025

High Cholesterol details

SCIENTIFIC SCORE

Questionable

Based on 3 Researches

Vitamin K2 reduces cholesterol, atherosclerosis

Kawashima H, Nakajima Y, Matubara Y, Nakanowatari J, Fukuta T, et al. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. Jpn J Pharmacol. 1997;75:135.

We explored whether vitamin K2, a form of vitamin K, could help in managing high cholesterol and atherosclerosis in rabbits with elevated cholesterol levels.

Over a span of ten weeks, we administered different doses of vitamin K2 to rabbits fed a cholesterol-rich diet.

The findings were encouraging; the vitamin K2-treated rabbits had significantly lower cholesterol levels compared to a control group.

Additionally, it seems that vitamin K2 at moderate doses helped slow down the development of atherosclerosis without any adverse effects on blood coagulation.

Effective for cholesterol

Most Useful Review

1 people found this helpful

It is beneficial for those with high cholesterol or harmful fats. I find it essential and encourage others to order it regularly due to its numerous benefits.

Updated: Mar 2026

We designed a multicenter, double-blind, placebo-controlled trial to explore if vitamin K2 can effectively manage nocturnal leg cramps (NLCs).

Conducted in China with older adults experiencing regular cramps, participants were randomly assigned to receive either vitamin K2 or a placebo for 8 weeks. Remarkably, our findings demonstrated that vitamin K2 significantly reduced the frequency, duration, and intensity of NLCs, making it a promising option for those suffering from this discomfort.

Notably, the treatment showed good safety profiles, reinforcing its potential utility in managing leg cramps.

Heaviness reduced

Most Useful Review

I purchased this for bone and cardiovascular health and was very pleased! The fact that it is vegetarian suits my dietary preferences. After a month of taking it, I've felt significant positive changes; notably, the heaviness in my legs has greatly diminished, contributing to my overall well-being. The 100 mcg dosage is ideal for daily intake. I intend to continue using it as vitamin K2 is crucial for calcium absorption. I recommend it to anyone concerned about health!

Updated: Apr 2025

Menopause details

SCIENTIFIC SCORE

Possibly Effective

Based on 16 Researches

MK-7 supports bone health post-menopause

Knapen MH, Drummen NE, Smit E, Vermeer C, Theuwissen E. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int. 2013;24:2499. doi:10.1007/s00198-013-2325-6

We explored the potential benefits of low-dose vitamin K2, specifically menaquinone-7 (MK-7), on bone health in healthy postmenopausal women. Over a three-year study with 244 participants, we found that MK-7 significantly improved bone mineral density and strength, suggesting it could mitigate age-related bone loss.

While the results are promising for postmenopausal women, more research is needed to determine if these findings apply to other groups, such as men and children.

Menopausal supplement

Most Useful Review

This is a perfect supplement for the effects of menopause; I have little in my diet.

Updated: Mar 2026

Pelvic Pain details

8 people found this helpful

Excellent! The quality and ingredients are beneficial. Taking it with Vitamin D and Omega 3 has eliminated my bone pain and pelvic pain. It has no taste, and I highly recommend this combination for better results, especially since it's cheaper on iHerb.

Updated: Apr 2025

Heart Disease details

SCIENTIFIC SCORE

Questionable

Based on 6 Researches

Vitamin K1 reduces coronary calcifications

Macias-Cervantes HE, Ocampo-Apolonio MA, Guardado-Mendoza R, Baron-Manzo M, Pereyra-Nobara TA, et al. Effect of vitamin K1 supplementation on coronary calcifications in hemodialysis patients: a randomized controlled trial. J Nephrol. 2025;38:511. doi:10.1007/s40620-024-02154-9

We aimed to determine how vitamin K1 affects coronary artery calcifications in patients undergoing hemodialysis. In our study with 60 participants, we compared the effects of intravenous vitamin K1 against a placebo over 12 months.

The results showed that vitamin K1 significantly slowed the progression of coronary artery calcifications by 55%, compared to the placebo group. This finding suggests vitamin K1 may offer an important benefit in managing heart health for those with chronic kidney disease.

Reduced artery plaque

Most Useful Review

44 people found this helpful

It has worked wonders for my dental health. After my heart attack in February 2018, I followed an aggressive plant-based diet alongside taking this product with vitamin D3. A recent calcium scoring CT scan revealed that the plaque in my left artery has decreased from severe to moderate, and the other arteries show no plaque. I'm truly grateful for this outcome, as it significantly aids in treating heart disease.

Updated: Mar 2026

Kidney Stones details

Vitamin K1 may reduce kidney stones

Li Y, Lu X, Yang B, Mao J, Jiang S, et al. Vitamin K1 Inhibition of Renal Crystal Formation through Matrix Gla Protein in the Kidney. Kidney Blood Press Res. 2019;44:1392. doi:10.1159/000503300

We explored the effect of vitamin K1 (VK1) on kidney stone formation by treating rats for eight weeks. Our observations showed that VK1 significantly reduced crystal formation in the kidneys.

It boosted levels of matrix Gla protein, which plays a crucial role in preventing crystal deposition. We noticed that VK1 even countered the negative effects of warfarin on cell viability. Overall, our findings suggest that VK1 could be a promising treatment to help prevent kidney stones.

Kidney stone prevention

Most Useful Review

I take vitamin K with vitamin D in the morning. Vitamin K is important for regulating calcium and phosphorus metabolism and helps prevent kidney stones.

Updated: Mar 2026

Cancer details

SCIENTIFIC SCORE

Possibly Effective

Based on 16 Researches

PIVKA-II shows promise for HCC

Chen SC, Ho HL, Liu CA, Hung YP, Chiang NJ, et al. PIVKA-II as a surrogate biomarker for therapeutic response in Non-AFP-secreting hepatocellular carcinoma. BMC Cancer. 2025;25:199. doi:10.1186/s12885-025-13568-4

We aimed to discover how well PIVKA-II can predict treatment response in patients with non-AFP-secreting hepatocellular carcinoma (HCC) receiving systemic therapy.

By measuring PIVKA-II levels and assessing imaging after 8-12 weeks of treatment, we found a connection between PIVKA-II levels, tumor size, and treatment outcomes.

The study revealed a promising “50-50 rule” that can indicate prognosis based on PIVKA-II changes, making it a valuable marker for HCC treatment success.

7.5

Promotes cellular health

Most Useful Review

8 people found this helpful

One of the few products that is exclusively MK-4. While many emphasise the MK-7 form of Vitamin K2 for its calcium-enhancing qualities, I prefer MK-4 as it is found in the brain and regulates gene expression uniquely. It activates genes that maintain cell health while deactivating those that promote cancer. Animals convert other forms of Vitamin K to MK-4, but this process is inefficient and varies by genetics, making MK-4 supplementation potentially beneficial. However, some argue that MK-4 supplements are synthetic and may have low bioavailability.