Nature's Bounty Melatonin

We focused on the effects of oral melatonin on anxiety and pain in children during the stressful process of venipuncture. In a double-blind, randomized controlled trial, we found that administering 0.5 mg/kg of melatonin 30 minutes before the procedure significantly reduced both pain and anxiety levels compared to a placebo.

The results showed that only 18.8% of the kids receiving melatonin reported pain, while 78.2% in the placebo group did. Furthermore, anxiety affected 44.6% of the melatonin group compared to 94.1% of those in the control group.

While melatonin appeared to improve experiences during venipuncture, its impact on the success rate was not statistically significant.

8.8

Eases anxiety thoughts

Most Useful Review

My kids have enjoyed this quality product for a year now. It helps them settle down for the night and prevents them from getting caught up in anxious thoughts. It has been a great benefit for us.

Insomnia details

SCIENTIFIC SCORE

Possibly Effective

Based on 23 Researches

Melatonin delivery enhances sleep

Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation.

Most Relevant Research

We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.

Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.

Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.

We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.

9.5

Sleep deprivation relief

Most Useful Review

If you have insomnia, try this! With a history of intermittent insomnia, this product saved me from sleep deprivation while working night shifts. Initially sceptical due to past melatonin experiences, I decided to try it following my manager's recommendation. Surprisingly, it worked; I felt sleepy within 15 minutes and was fast asleep in 30. Despite my dislike for dissolvable tablets, I find this tolerable and will continue using it.

Sleep Apnea details

SCIENTIFIC SCORE

Possibly Effective

Based on 4 Researches

Melatonin improves sleep apnea outcomes

Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial.

Most Relevant Research

We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.

The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.

Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.

9.5

Sleeping soundly

Most Useful Review

There's definitely a benefit! My husband constantly suffers from sleep issues, struggling to fall asleep or waking during the night, lying awake until morning. Melatonin has been a perfect solution; he takes it 1-1.5 hours before bed and sleeps soundly without waking. He wakes up feeling very refreshed.

Headache details

SCIENTIFIC SCORE

Possibly Effective

Based on 15 Researches

Agomelatine relieves hypnic headaches

Case report: Hypnic headache responds to agomelatine-a potential prophylactic treatment option.

Most Relevant Research

We explored how melatonin-based treatments, particularly agomelatine, can affect headaches, focusing on hypnic headaches (HH). This form of headache typically occurs during sleep, disrupting the rest of those affected. A fascinating case of a 58-year-old woman who experienced these nocturnal headaches for three years demonstrated the potential benefits of agomelatine.

After being prescribed 25 mg of agomelatine at bedtime, she reported an impressive 80% reduction in headache frequency and severity within a month. Remarkably, her headaches completely resolved after three months, allowing her to discontinue the medication.

This case highlights the importance of exploring prophylactic treatments aimed at reducing nighttime awakenings caused by HH. Given the significant impact these headaches can have on sleep quality in older populations, treatments that target melatonin receptors could offer a promising avenue for relieving this condition.

8.8

No headache

Most Useful Review

Delicious and effective melatonin capsules that are small and have a pleasant taste. The dosage is perfect for me. I wake up without a headache and don’t feel groggy.

Dizziness details

Melatonin's impact on dizziness

Addressing Sleep Disorders in Psychiatry: Comparing the Use of Melatonin, Trazodone, and Doxepin.

Most Relevant Research

We assessed how melatonin affects dizziness in patients dealing with sleep disturbances tied to psychiatric conditions. In a study with 175 participants, we found that melatonin was slightly less effective than trazodone and doxepin in improving overall sleep quality. However, it stood out for having a low incidence of adverse effects. Specifically, the rates of dizziness associated with melatonin use were measured, showing a relatively low occurrence.

While it did not provide the most substantial improvement in sleep quality, melatonin showed promise in enhancing tolerability among users. Only 10% of participants reported dizziness, which indicates that melatonin might be a safer option for those worried about side effects from more potent medications. By choosing melatonin, patients can potentially find a balance between managing sleep disturbances while minimizing unwanted symptoms like dizziness.

Overall, we observed that for individuals focused on avoiding adverse effects, melatonin serves as a viable alternative within this treatment landscape. Its effectiveness in curbing dizziness contributes to discussions on how best to treat sleep disorders in psychiatric patients without compromising their comfort.

9.5

Helps sleep well

Most Useful Review

Melatonin has become my go-to choice, and this is my second purchase. The tiny pills have a pleasant cherry taste, making them easy to swallow. I find 3mg to be the ideal dose, especially as most melatonin products in Hong Kong are available only in 5 or 10mg. I take it around 15-20 minutes before bedtime, and it helps me drift off without experiencing dizziness the following day.