Melatonin delivery enhances sleepSilk fibroin microneedles loaded with melatonin for circadian rhythm regulation.
We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Sleep deprivation relief
Most Useful Review
12 people found this helpful
If you have insomnia, try this! With a history of intermittent insomnia, this product saved me from sleep deprivation while working night shifts. Initially sceptical due to past melatonin experiences, I decided to try it following my manager's recommendation. Surprisingly, it worked; I felt sleepy within 15 minutes and was fast asleep in 30. Despite my dislike for dissolvable tablets, I find this tolerable and will continue using it.