Solgar Vitamin B12

We conducted a thorough investigation to understand whether intramuscular vitamin B12 treatment could effectively relieve low back pain. This study was designed as a double-blind, placebo-controlled trial involving 60 patients aged 18 to 65 who suffered from mechanical low back pain or sciatic neuritis. Each participant had a history of back pain lasting from six months to five years and reported significant pain intensity according to a standard scale.

By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.

Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.

9.5

Helps back pain

Most Useful Review

I use this product for back pain caused by my job. It is extremely useful.

Leg Cramps details

I ordered this for my daughter, who suffered from vitamin B12 deficiency, leading to issues with movement and leg cramps that could last for about an hour. After a full course of B12 injections with little success, she started using Solgar's vitamin B12. Happily, she is now free from leg cramps and has overcome her deficiency. Thank you, Solgar!

Anemia details

SCIENTIFIC SCORE

Moderately Effective

Based on 11 Researches

Vitamin B12 effectively treats anemia

An Unusual Case of Hemolytic Anemia: A Case Report.

Most Relevant Research

We observed a compelling case surrounding the impact of vitamin B12 on anemia, particularly in a 62-year-old man facing severe deficiencies due to factors like drug use, hepatitis C, smoking, and alcoholism. Initially, this patient presented with symptoms such as fatigue, fever, and confusion, raising concerns about more critical conditions like thrombotic thrombocytopenic purpura (TTP). Laboratory tests indicated severe pancytopenia and signs of hemolysis, making the situation quite alarming.

However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.

This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.

9.5

Anemia symptoms relieved

Most Useful Review

I didn’t consume much meat or fish, which led to some symptoms of anaemia. Since taking this vitamin B12 supplement, my symptoms have vanished. I believe this one is of high quality, as other brands didn’t have the same effect.

Bone Pain details

I use this product due to back pain caused by my job. It is very effective.

Chronic Fatigue Syndrome details

SCIENTIFIC SCORE

Questionable

Based on 7 Researches

Vitamin B12 ineffective for CFS

N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.

Most Relevant Research

We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.

In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.

These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.

9.5

Increased energy levels

Most Useful Review

I began taking vitamin B12 and quickly noticed a positive effect. This vitamin is crucial for maintaining normal energy levels and a healthy nervous system. Almost immediately, I felt less fatigued and my mental clarity improved. B12 is vital for those with chronic fatigue syndrome, particularly as it aids in appetite regulation when deficiency is an issue. The capsules are easy to swallow and I’ve experienced no side effects. If you're suffering from fatigue or concentration issues, I highly recommend this supplement!

Heart Disease details

SCIENTIFIC SCORE

Questionable

Based on 4 Researches

Vitamin B12 helps heart recovery

Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.

Most Relevant Research

We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.

Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.

Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.

Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.

8.8

Vitamin B12 benefits

Most Useful Review

Vitamin B12, a vital B-complex nutrient, aids energy metabolism and promotes a healthy nervous system. It, along with folic acid and vitamin B6, supports heart health by maintaining normal homocysteine levels. B12 is essential for the development and regeneration of red blood cells, which deliver oxygen throughout the body, particularly relevant for treating heart disease.