Solgar Zinc 50 mg

Zinc effective for acne treatment

Based on 16 Researches

Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis.

Most Relevant Research

We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.

Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.

Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!

9.5

Cleared skin

Most Useful Review

Zinc is a miracle! I suggest it for maintaining healthy skin, hair, and nails. My subcutaneous acne has vanished, and my hair and nails are thriving.

Cancer

Zinc's role in cancer immunity

Based on 6 Researches

cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance.

Most Relevant Research

We explored how zinc levels impact cancer cells and immune function, particularly focusing on macrophages, which are crucial for our body’s defense against tumors. Our research revealed that cancer cells often have decreased expression of specific genes tied to immune response, and this links to resistance against therapies designed to unblock immune checkpoints.

By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.

Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.

Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.

9.5

Supports immune system

Most Useful Review

I believe these tablets significantly aided my recovery from COVID. They are easy to swallow and don’t feel too small. They certainly bolster my immune system. As a cancer survivor with no spleen, I require assistance in combating viruses. Solgar's quality, as ever, is exceptional.

Cold Sores

Zinc cream alleviates cold sores

Based on 9 Researches

A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine.

Most Relevant Research

We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.

Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.

As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.

9.5

Cleared acne quickly

Most Useful Review

I can confidently say this dietary supplement worked wonders for me. After suffering from painful subcutaneous acne for years, a dermatologist's treatment failed. However, after a week of taking zinc, my face cleared completely. Though acne returned after six months, resuming zinc for just three days eliminated it again.

Common Cold

Zinc shortens cold duration variability

Based on 6 Researches

Quantile Treatment Effect of Zinc Lozenges on Common Cold Duration: A Novel Approach to Analyze the Effect of Treatment on Illness Duration.

Most Relevant Research

We explored how zinc lozenges affect the duration of the common cold through a detailed analysis of multiple trials. In particular, we focused on the Mossad (1996) trial involving zinc gluconate lozenges, which revealed an average reduction of cold duration by about 4.0 days. While that sounds promising, our findings through a quantile treatment effect (QTE) analysis tell a more nuanced story.

Interestingly, the QTE analysis showed that for individuals suffering from lengthy colds lasting 15 to 17 days, the zinc lozenges could shorten their illness by as much as 8 days. On the flip side, those with shorter, 2-day colds only experienced a 1-day reduction in sickness. This suggests that while zinc may help, its effectiveness varies significantly depending on the initial duration of the cold, making the overall average effect less informative than we might think.

Our examination extended to three trials that used zinc acetate lozenges, yielding a similar average reduction of around 2.7 days. However, again, those averages concealed varying effects for short and long colds, highlighting the importance of looking beyond simple averages in treatment studies.

Overall, we observed that zinc lozenges can indeed help with cold duration, but the extent of that help is very much dependent on how long a person has been suffering. This approach to understanding treatment effects through QTE analysis could have important implications not just for cold treatment but also for analyzing other health outcomes.

9.5

Strengthens immunity

Most Useful Review

I find zinc an effective supplement! It strengthens the immune system, improves skin, and prevents hair loss. I take it daily, especially since my diet lacks zinc-rich foods. Zinc also enhances male sexual health and fertility. My results are excellent: strong hair, clear skin, and robust immunity, with no colds for years. Highly recommend!

Eczema

Zinc enhances eczema recovery

Transient symptomatic zinc deficiency in an exclusively breastfed infant.

Most Relevant Research

We investigated the relationship between zinc deficiency and eczema in a 3-month-old infant who was exclusively breastfed. The infant presented with symptoms like scaling erythematous dermatitis affecting her face and other areas, alongside irritability and poor weight gain. Her mother had been taking isoniazid for tuberculosis during pregnancy, which possibly contributed to the infant’s zinc deficiency.

After initial treatments for a suspected skin infection didn’t bring any changes, we found that the baby had low serum zinc levels and low zinc concentration in her breast milk. This led us to believe the skin condition was due to zinc deficiency rather than an infection. We started zinc supplementation, and the infant showed remarkable improvement in her skin condition and weight.

By 6 months, the infant had begun eating solid food, and we stopped the zinc supplements, with no signs of eczema returning. This case underscores the importance of monitoring zinc levels in breastfed infants, especially when mothers are on specific medications that might impact nutrient transfer through breast milk.

9.5

Improved skin condition

Most Useful Review

I recommend this product! I bought it for my husband who has eczema. His skin was peeling and my hands were cracked. The dermatologist advised taking a course of zinc, so I chose Solgar's chelated form. To my surprise, his skin has greatly improved — the peeling has stopped. I definitely recommend it!

Heart Attack

ZnO NPs protect heart health

Based on 9 Researches

In vivo cardioprotective effect of zinc oxide nanoparticles against doxorubicin-induced myocardial infarction by enhancing the antioxidant system and nitric oxide production.

Most Relevant Research

We aimed to explore how zinc oxide nanoparticles (ZnO NPs) could protect the heart from damage caused by doxorubicin, a drug that can lead to serious heart issues, including myocardial infarction (MI). Our study involved rats that were injected with doxorubicin to induce MI and then treated with ZnO NPs at two different doses.

Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.

Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.

9.5

Improved heart condition

Most Useful Review

I suffered a heart attack in September 2019, and after a recurrence two months later, I discovered a book by Dr. Mitsuishi and Dr. Fujikawa in November 2020. After starting this supplement, my seizures have not returned, my arrhythmia has stabilised, and my wife's trigger finger has improved. Although I began using multiple supplements simultaneously, I can feel the positive effects on both of us.

Hypothyroidism

Zinc's uncertain role in hypothyroidism

The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial.

Most Relevant Research

We conducted a study to investigate the effects of micronutrient supplementation, including zinc, on thyroid function and overall quality of life in patients with hypothyroidism. Our trial involved 104 participants who were receiving levothyroxine and vitamin D. They were randomly assigned to either a group that received a mix of essential nutrients or a placebo group over eight weeks.

We measured various health markers before and after this period, including thyroid hormone levels, cholesterol, insulin resistance, and blood pressure. Our findings suggested that the group receiving the micronutrient supplement experienced improvements in insulin resistance and overall quality of life. However, it’s important to note that the specific effects of zinc alone are somewhat difficult to isolate, as it was part of a combination of nutrients being tested.

Ultimately, while the study indicates potential benefits of micronutrient supplementation for thyroid function in hypothyroid patients, further trials are necessary to clearly define the role of zinc and other nutrients in this context.

8.8

Stable condition

Most Useful Review

I get checked for hypothyroidism every six months. My doctor mentioned that my numbers were worsening and that my medication could be adjusted accordingly. However, despite this, I took the supplement daily after meals, and when I returned to the hospital six months later, I was delighted to find that my numbers were stable, allowing me to continue with the same medication.

Influenza

Zinc may prevent influenza entry

Based on 2 Researches

Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry.

Most Relevant Research

We investigated how zinc, delivered through epipharyngeal abrasive therapy (EAT), might impact the expression of a key molecule known as Cav1.2, which plays a crucial role in allowing the influenza A virus to enter cells. The study included two groups of patients: one group that received EAT, which involved scratching the epipharyngeal mucosa with a zinc chloride-treated swab, and another group that did not receive this treatment.

By analyzing tissue samples, we observed that the levels of Cav1.2 were significantly lower in the EAT-treated patients compared to those who were not treated. In fact, the expression of Cav1.2 in the patients who underwent EAT was measured to be 4.19 times lower than in the non-treated group. This suggests that the squamous metaplasia induced by EAT might help reduce the entry of the influenza virus by down-regulating this key protein.

Our findings indicate that EAT, through its zinc content, could serve as a simple and effective method to potentially prevent influenza infection by limiting the virus's ability to enter cells.

9.5

Immunity support

Most Useful Review

I adjust my zinc intake based on my health needs, especially during illness. Zinc is crucial for immunity and prostate health, as the body can't store it. Deficiency can cause numerous health issues, so it’s vital to ensure adequate intake, especially during influenza.

Insomnia

Zinc promotes sleep in mice

Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice.

Most Relevant Research

We explored the effects of zinc on sleep by looking at how it might help with insomnia. In our study, we gave mice a zinc-containing yeast extract and monitored their behavior and brain activity. The results were quite promising.

We found that administering zinc at doses of 40 and 80 mg/kg led to a significant increase in non-rapid eye movement (NREM) sleep. This means that the mice were not only sleeping longer but also showed less activity, which is a good indicator of effective sleep. Interestingly, we did not observe any changes in rapid eye movement (REM) sleep, a crucial sleep phase for dreaming and deep rest.

Importantly, we didn’t see any negative side effects, such as rebound insomnia, within 24 hours after treating the mice. This suggests that zinc could be a safe option for those struggling with sleep issues, unlike other mineral extracts we tested, such as manganese, iron, and copper, which did not affect locomotor activity at all.

Overall, our findings provide the first evidence that zinc has a direct role in promoting sleep, opening up exciting possibilities for new sleep supplements featuring this essential mineral.

Insomnia resolved

Most Useful Review

Insomnia has been resolved. I came to realise that my body wasn’t sufficient.

Knee Pain

Excellent for knee pain and inflammation of the tendons related to the knee. I recommend it for improving ease of movement and daily activities.

Menopause

Zinc enhances vitamin D in menopause

Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial.

Most Relevant Research

We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.

Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.

Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.

Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.

9.5

Improves menopause

Most Useful Review

Excellent! I love that it comes in a glass pot, which is of better quality. It's a good size, contains 50 mg, and the other ingredients are clean. It helps me to improve my menopause and boost my immune system. 😜

Migraine

Zinc reduces migraine symptoms

Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women.

Most Relevant Research

This study was designed as a randomized double-blind, placebo-controlled trial to examine how zinc gluconate supplementation might alleviate migraine symptoms in adult women. We followed 60 women, averaging about 35 years old, who either received 15 mg of zinc per day or a placebo for a duration of 12 weeks.

Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.

Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.

Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.

9.5

Migraine relief

Most Useful Review

Regular intake of two capsules normalises my sleep and improves my migraines. When symptoms arise, I take the pills along with extra magnesium, and the migraine dissipates within a couple of hours. The frequency of my migraines has decreased, especially with additional support. Magnesium has made my PMS and menstruation much easier, reducing irritability and alleviating first-day pain without painkillers. I didn’t experience any allergies or stomach issues, and the quality of the product is excellent with natural ingredients.

Prostate Cancer

Zinc's complex role in prostate cancer

Prostate cancer-selective anticancer action of an oxindole derivative via HO-1-mediated disruption of metabolic reprogramming.

Most Relevant Research

We explored the relationship between zinc levels and prostate cancer treatments, particularly focusing on a novel compound known as 3D. This compound showed a strong potential to target prostate cancer cells, contributing to a decrease in their proliferation rates.

Our analysis revealed that compound 3D selectively impacted key metabolic processes in prostate cancer cells by suppressing factors related to energy production, such as lactate levels. Interestingly, it also reduced the activity of transporters involved in zinc absorption while leaving those responsible for zinc export untouched.

We also found that the effectiveness of 3D could be reversed with zinc treatment, highlighting a complicated interaction between zinc and this therapeutic approach. While the compound successfully lowered zinc levels in cells and inhibited cancer growth, it is essential to note that we did not find significant benefits from zinc treatment by itself in the context of this study.

Overall, our findings suggest that targeting zinc metabolism and enhancing heme oxygenase-1 expression could be a promising strategy in prostate cancer therapy, more so than the direct application of zinc itself. The results illustrate the potential for combining innovative small molecules with an understanding of cancer metabolism in the development of treatment strategies.

9.5

Improves prostate results

Most Useful Review

My father had concerning prostate cancer markers. After consuming two bottles, the results have significantly improved. He intends to continue.

Rosacea

Zinc penetrates skin in rosacea

Based on 2 Researches

Zinc penetration through the skin barrier in atopic dermatitis and rosacea using reflectance confocal microscopy.

Most Relevant Research

We investigated how well zinc penetrates the skin in individuals with rosacea, a common condition that affects skin barrier function. Using a non-invasive technique called reflectance confocal microscopy, we compared the skin barrier permeability between those with rosacea, atopic dermatitis, and healthy individuals.

Our results revealed that zinc penetration was greater in patients with rosacea compared to those with healthy skin. Specifically, we observed higher intensity readings of zinc at a depth of 8 micrometers in the skin of rosacea patients. This indicates that their skin barrier might be more compromised in the upper layers.

Interestingly, when comparing both conditions, we found that patients with atopic dermatitis showed greater zinc penetration at deeper layers of the skin. This suggests subtle differences in how these two conditions affect skin barriers. Overall, the findings suggest that patients with rosacea experience increased permeability in the upper layers of the skin due to weakened barrier function.

9.5

Reduces facial rashes

Most Useful Review

I continuously take it for my rosacea, and it greatly helps manage facial rashes and inflammation. The problems are linked to the sebaceous glands, and zinc effectively alleviates these issues. I highly recommend it to anyone facing similar challenges.

Tinnitus

Zinc intake affects tinnitus risk

The Association between Dietary Intakes of Vitamins and Minerals with Tinnitus.

Most Relevant Research

We examined how dietary intakes of vitamins and minerals, particularly zinc, could influence the onset and presence of tinnitus, a condition characterized by phantom sounds in the ears. In a study involving nearly 3,000 participants over the age of 50, we identified cases of tinnitus to determine if their dietary habits played a role in their experience of this condition.

The findings indicated that while there were no significant associations between overall vitamin and mineral intake and existing tinnitus prevalence, zinc intake stood out in relation to developing tinnitus over time. Specifically, we observed that lower zinc consumption was linked to a 44% increased risk of experiencing tinnitus over a ten-year period.

Furthermore, we noted that iron intake also showed a significant correlation, with lower iron levels raising incident tinnitus risk by approximately 35%. These results highlight the potential importance of maintaining adequate zinc and iron levels in our diets to help reduce the risk of developing tinnitus.

9.5

Aids tinnitus relief

Most Useful Review

I purchased it as it helps with tinnitus.

Tonsillitis

Zinc in supplement reduces tonsillitis symptoms

The Effectiveness of a Dietary Supplement with Honey, Propolis, Extract, and Zinc in Children Affected by Acute Tonsillopharyngitis: An Open, Randomized, and Controlled Trial.

Most Relevant Research

This study took a closer look at the effects of a dietary supplement, PediaFlù, which includes honey, propolis, and zinc, on children suffering from acute tonsillopharyngitis, a common throat infection. We explored how well this supplement worked alongside standard care compared to standard care alone over six days.

The results were quite encouraging! We found that children who received the supplement alongside standard treatment reported lower throat pain and erythema (redness of the throat) by day six. There were also improvements in swallowing and overall throat severity scores by days four and six. Interestingly, only one child in the standard care group needed additional treatment with ibuprofen, suggesting that the supplement may help alleviate symptoms effectively.

However, it's important to note that while zinc was part of this combination treatment, the study focused on the overall effect of all components together. We couldn't isolate zinc's individual impact on tonsillitis specifically. That said, the findings point to the possibility of using this dietary supplement as a helpful adjunct in treating upper respiratory tract infections, which may reduce unnecessary antibiotic use in pediatric care.

9.5

Tonsillitis relief

Most Useful Review

Solgar is my favourite ❤️. I ordered it after the pandemic to boost my immunity. I noticed that my chronic tonsillitis has disappeared, and it works brilliantly. 👍

Cold

Zinc’s effects on colds

Zinc for prevention and treatment of the common cold: Summary of a Cochrane review.

Most Relevant Research

We explored how zinc might help in treating and preventing the common cold. The study focused on zinc's effects, isolating it from other treatments to understand its true impact on cold symptoms. By doing this, the researchers aimed to clarify whether zinc could genuinely shorten the duration of a cold or alleviate its symptoms.

The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.

This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.

9.5

Shortens cold duration

Most Useful Review

The tablets of zinc are easy to swallow and really help me recover from colds faster. I initiated my father on a zinc regimen, and he hasn’t been ill since, feeling healthier and more active after a month. I highly recommend this product for anyone wishing to holistically shorten their cold’s duration and enhance their well-being!

Anemia

Questionable

Zinc deficiency linked to anemia

Zinc Deficiency Presenting With Diverse Symptoms in a Young Patient: A Case Report.

Most Relevant Research

We explored the connection between zinc deficiency and anemia through the case of an 18-year-old woman who faced a series of health issues, including urinary tract infections and insulin dysfunction. After a thorough assessment, she was diagnosed with zinc deficiency, shedding light on how this overlooked issue can impact overall health.

What stood out to us was the rapid recovery the patient experienced after beginning oral zinc supplementation. Zinc plays a critical role in numerous bodily functions, including immune support and protein regulation. By addressing her deficiency, we observed significant improvement in her symptoms, including anemia.

The patient’s diet contained high levels of substances that were inhibiting her zinc absorption, which likely contributed to her condition. This case emphasizes the importance of recognizing zinc deficiency as a potential underlying cause for unexplained health issues, particularly anemia. Prompt diagnosis and treatment can lead to a complete turnaround in the patient's health.

By sharing this experience, we hope to raise awareness among clinicians about the vital role of zinc in managing anemia and encourage timely interventions for patients showing diverse symptoms.

8.8

Immediate results

Most Useful Review

Gorgeous brand. My child has anemia and struggles with vitamin absorption. This zinc produced immediate results.

Diet-derived circulating antioxidants and risk of epilepsy: a Mendelian randomization study.

Most Relevant Research

We explored the relationship between zinc and epilepsy by conducting a Mendelian randomization analysis. This study focused on understanding whether dietary zinc could potentially influence the risk of developing epilepsy. Our investigation involved looking into various antioxidants commonly found in the diet, such as selenium and vitamins A, C, and E, alongside zinc. However, we found that zinc was the only antioxidant linked to epilepsy risk.

Our analysis demonstrated that a genetic prediction of increased zinc was positively associated with several types of epilepsy, including general and focal types. Specifically, an increase in zinc levels was correlated with a higher likelihood of experiencing epilepsy. Yet, the other antioxidants we examined didn't show any significant effect on epilepsy risk.

These findings highlight the need for further research into zinc's role in epilepsy management. While zinc appears to have a direct relationship with epilepsy, the implications of using it as a treatment option still require careful consideration, especially since no other dietary antioxidants had a measurable effect.

8.8

Reduced seizures

Most Useful Review

Effective! Zinc is crucial for the human body and plays a role in various metabolic processes. With a deficiency, numerous diseases can arise. My family regularly consumes zinc, particularly as only 20-40% is absorbed from food. Zinc from animal sources is better absorbed than that from plants. To enhance absorption in vegetarian diets, soaking grains and legumes is beneficial. We've tried zinc from Solgar, which has been excellent. My father, who has epilepsy, experiences fewer seizures when taking zinc; thus, the benefits are clear.

Gout

Zinc nanoparticle aids gout treatment

A novel zinc ferrite nanoparticle protects against MSU-induced gout arthritis via Nrf2/NF-κB/NLRP3 pathway.

Most Relevant Research

We investigated how zinc, specifically in the form of zinc ferrite nanoparticles (ZFN), can impact gouty arthritis. The research focused on finding a safe and effective treatment option to help people dealing with this painful condition, which often affects various age groups.

To explore this, we created ZFN, which has notable activities that help combat inflammation and oxidative stress, while also being gentle on the body. What’s interesting about ZFN is that its low zinc content helps avoid some of the common issues with other zinc-based treatments, such as toxicity. We tested ZFN through both laboratory studies and real-life models to see its effectiveness fully.

Our results were promising! We observed that ZFN significantly reduced inflammation and oxidative stress associated with gout. It seems to work by influencing important body pathways, particularly weakening signals that promote inflammation while boosting the body's natural defenses. This modulation signifies a powerful method for treating gout without the heavy side effects of current medications.

The discoveries we made in this study not only highlight a new potential treatment for gouty arthritis but also demonstrate the wider applicability of nanotechnology in health. The protective benefits of ZFN pave the way for more developments in treating inflammatory conditions like gout.

8.8

Minor improvements noted

Most Useful Review

Once again, Solgar impresses with its quality. The distinctive brown glass jars with gold lids contain zinc in a therapeutic dosage of 50 mg, purchased for treating gout and psoriasis. My doctor suggested the dosage due to zinc deficiency. It is recommended to take it with food and plenty of water. There are no side effects, and I have noticed minor improvements. I hope for a long-term quality remission regarding my ailments. I would recommend this product.

Heartburn

Zinc's role in heartburn relief

Likely Very Effective

Esophageal ulcer related to zinc deficiency following a total gastrectomy.

Most Relevant Research

We investigated how zinc affects heartburn through the case of a 76-year-old Japanese man who experienced significant discomfort after undergoing a total gastrectomy. For two weeks, he suffered from a sore throat, heartburn, and difficulty swallowing. Endoscopy revealed deep, craterlike ulcers in his esophagus, but tests for viral infections were negative.

After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.

Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.

8.8

Gentle on stomach

Most Useful Review

Okay, the dosage is high, and I take it at night as prescribed by my doctor. It’s gentle on my stomach, with no heartburn or nausea, unlike some other brands.

Leg Cramps

I have managed to avoid leg cramps with these.

Psoriasis

Zinc conditioner benefits scalp psoriasis

Based on 5 Researches

Efficacy and safety of supramolecular active zinc in the treatment of scalp psoriasis: a multicentre, randomized, observed-blind, parallel-group, placebo- and active-controlled noninferiority trial.

Most Relevant Research

We delved into the effectiveness of a zinc-based hair conditioner specifically designed for treating scalp psoriasis. This study was a well-structured clinical trial involving 211 participants, where individuals were divided into three groups: those receiving the specialized zinc treatment, a placebo, and a control group given calcipotriol ointment. Remarkably, the trial was multicenter and observed-blind, which adds credibility to the findings.

Our results revealed that the zinc conditioner led to a 39% disease control rate after four weeks, compared to 25% for the placebo and 37% for the calcipotriol ointment group. This means that the zinc treatment significantly outperformed the placebo while being on par with the active control variant. In essence, those using the zinc product experienced better management of their scalp psoriasis than those using a non-active alternative.

Overall, our findings highlight that a supramolecular active zinc antidandruff formulation is not just effective for treating scalp psoriasis but also helps in maintaining results over time and potentially preventing future flare-ups. This offers a promising new avenue for patients seeking relief from this chronic condition.

8.8

Psoriasis relief achieved

Most Useful Review

This is excellent zinc that has effectively helped me with psoriasis. The quality of Solgar is consistently good, and I've noticed my hair becoming even stronger since taking it.

Reflux

Reduced reflux relief

Most Useful Review

I gave it all stars because it helped me reduce reflux before bed. I take the pills, and they work wonderfully to alleviate reflux when it occurs. However, recently I’ve felt some nausea after using it, which makes me hesitant to take it now. Despite this, it has been effective for me, at least for a time. If you appreciate my review, please give it a like! 🥰👍🏻

Flu

Zinc treatment impacts flu virus entry

Based on 5 Researches

Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry.

Most Relevant Research

In our study, we examined how epipharyngeal abrasive therapy (EAT), which includes the use of zinc chloride, affects the expression of a key molecule known as Cav1.2. This molecule is essential for the influenza virus to enter cells, making it a crucial target in flu prevention strategies.

We compared two groups of patients: those who received EAT and those who did not. Our findings revealed that the levels of Cav1.2 were significantly lower in the EAT group, at a striking 4.19 times less than in the non-treated group. This suggests that the squamous metaplasia induced by EAT—which is a process of changing the epithelium—could be a beneficial approach to limiting flu infections.

The results of the study highlight zinc's potential indirect role in flu prevention by remarking on its contribution to lowering the expression of a critical receptor for the virus. Although we didn't isolate the effects of zinc alone, the findings indicate that treatments involving zinc, like EAT, may offer a straightforward way to help limit the impact of influenza.

8.8

Shortened flu symptoms

Most Useful Review

Fantastic product from Solgar. I take it twice a week during flu season for prevention. My husband takes it whenever he feels unwell, and it helps shorten the flu or prevent it completely.

Bone Pain

Improved bone strength

Most Useful Review

The product quality is high, and the ingredients are essential for immunity, positively affecting health, even in winter. The small capsules are easy to swallow without discomfort. After six months, the dosage increased vitamin levels from 8 to 60. My immunity has strengthened significantly following the vitamin intake. While we obtain Vitamin D3 from sunlight, it is insufficient to counteract deficiencies. I have experienced reduced bone pain due to improved absorption from the high dosage.

Chronic Fatigue Syndrome

Zinc supplementation may benefit CFS

Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS.

Most Relevant Research

We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.

Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.

Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.

8.8

Improved immunity

Most Useful Review

Amazing quality for the price! I love Solgar products. Zinc was difficult to find locally during the pandemic. This product seems to help boost my immunity. I have chronic fatigue syndrome and struggle with sleep at night. Since adding Zinc to my regimen, I’ve noticed an improvement in my sleep. The product arrived quickly and safely. I've used this brand for years and find it to be a reliable quality vitamin.

Pancreatitis

Skin cleanliness improvement

Most Useful Review

I purchased this for my husband, as his skin is not clean, and zinc is beneficial for pancreatitis.

Gastritis

Zinc protects against gastritis damage

Based on 8 Researches

Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model.

Most Relevant Research

We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.

Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.

Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.

4.8

Pill upset stomach

Most Useful Review

The pill is quite large and initially caused stomach pain due to my gastritis. My sister also experienced discomfort. To alleviate this, I started taking it halfway through a meal, as taking it after eating still caused me pain. This adjustment helped improve my situation.

Autoimmune Disorder

Zinc supplementation benefits MS models

Based on 6 Researches

Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model.

Most Relevant Research

We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.

9.5

Health improvement

Most Useful Review

I always keep zinc in my first aid kit and ordered this for my sister on her dermatologist's recommendation. After two weeks of taking it, her wounds healed better, and her overall health improved, including reduced hair loss.

Constipation

Zinc may mitigate granisetron constipation

Carbon monoxide contributes to the constipating effects of granisetron in rat colon.

Most Relevant Research

We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.

Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.

Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.

4.5

Iron deficiency aid

Most Useful Review

A nutritional supplement for those suffering from iron deficiency. One must drink plenty of water with any iron supplement, as one of its symptoms is constipation.

Allergies

Zinc may relieve allergy symptoms

Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.

Most Relevant Research

We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.

Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.

The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.

Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.

9.5

Effective against allergies

Most Useful Review

Excellent! I ordered this zinc for my mother-in-law, who suffers from terrible seasonal allergies. It really helps her with daily doses. Zinc decreases susceptibility to allergies and autoimmune disorders, is effective in seasonal allergic rhinitis, and aids breathing.

Urinary Tract Infection

Zinc-Infused Catheters Reduce Infections

Based on 5 Researches

Antimicrobial and Antibiofilm Activities of Urinary Catheter Incorporated with ZnO-Carbon Nanotube.

Most Relevant Research

We investigated the potential of a new type of urinary catheter to tackle catheter-associated urinary tract infections (CAUTIs). By incorporating zinc oxide-carbon nanotubes (ZnO-CNT) into a silicone catheter, we explored how this innovative design could inhibit infection-causing bacteria effectively.

Utilizing a combination of laboratory techniques like scanning electron microscopy and dynamic light scattering, we analyzed the structure of our ZnO-CNT catheter, which showed promising antibacterial properties. Notably, we found that the ZnO-CNT infusion significantly reduced biofilm formation—one of the main challenges in urinary catheters—demonstrating up to 56% inhibition in bacterial growth compared to standard silicone catheters.

The study revealed that ZnO-CNT not only holds antimicrobial potential but may also provide a more comfortable alternative to existing metal-coated options, like those using silver or gold. With our findings, we hope to present a viable strategy for reducing the discomfort and risks associated with traditional catheters while addressing a prevalent healthcare concern.

Frequent urination effect

Most Useful Review

Immediately after taking this zinc, I had severe urinary frequency for two days. I won't purchase it again.

Chest Pain

Zinc treatment for angina pectoris

Likely Very Effective

High-dose zinc to terminate angina pectoris: a review and hypothesis for action by ICAM inhibition.

Most Relevant Research

We delved into an intriguing question: Can high doses of zinc help relieve chest pain caused by angina pectoris? Our research reviewed studies that highlight how zinc may play a role in managing this condition. Angina pectoris often results from arteriosclerosis, where the arteries become narrowed due to cholesterol buildup and other factors.

We discovered that patients with severe atherosclerosis showed promising improvements when treated with high-dose zinc. Specifically, a treatment regimen involved raising serum zinc levels significantly, resulting in symptom relief for many individuals. In one notable case, 12 out of 16 patients experienced measurable benefits, including one patient who also suffered from Raynaud's disease.

Furthermore, our analysis noted that long-term exposure to zinc in the environment correlated with reduced incidence of angina and ischemic events during exercise. Zinc appears to possess antioxidant properties, which may protect against the oxidation of LDL cholesterol, a key player in artery damage. By blocking certain inflammatory factors and promoting better circulation, zinc might enhance heart function and alleviate chest pain.

Based on these findings, we propose that zinc treatment should be considered a fundamental option in both prevention and therapy for atherosclerosis-related chest pain. This could lead to a renewed focus on restoring a healthier cardiac function among those affected by these conditions.

1.3

Severe stomach pain

Most Useful Review

I experienced severe stomach pain almost an hour after taking it.

Food Poisoning

Zinc oxide combats foodborne pathogens

Active Packaging of Immobilized Zinc Oxide Nanoparticles Controls Campylobacter jejuni in Raw Chicken Meat.

Most Relevant Research

We set out to explore how zinc oxide nanoparticles (ZnO NPs) could help control the bacteria responsible for food poisoning in raw chicken meat. Our approach involved integrating these nanoparticles into packaging materials to see if they could effectively inactivate Campylobacter jejuni, a common and concerning pathogen in poultry.

Through our experiments, we discovered that immobilizing ZnO NPs in functional pads placed under raw chicken could dramatically reduce bacterial counts. In fact, we saw a reduction from about 4 log CFU to an undetectable level within just three days when storing chicken at 4°C. Notably, we monitored zinc levels in the chicken meat, confirming a safe release of zinc without any migration of nanoparticles onto the food. This means that we can help keep raw chicken safe and fresh without compromising its integrity or quality.

Not only did we find that these functional pads inactivated the harmful bacteria, but we also noted a related increase in lactic acid production, which plays a role in further protecting the meat. Our findings open up new avenues for using zinc in food packaging, offering a way to enhance food safety without directly adding chemicals to the food itself. Overall, this study highlights the potential for nanotechnology to play a significant role in managing foodborne pathogens like Campylobacter in poultry products.

7.5

Super results

Most Useful Review

I bought zinc on my doctor's advice for my worsening skin condition. My skin has improved, and I feel better. It's crucial to take it with food to avoid nausea; I found taking it at lunch or dinner works best for me. I also recommend taking copper with zinc, as zinc can wash it out. Next time, I'll opt for zinc picolinate for better absorption.

Headache