Thorne Ultimate-E

Supplement Facts

Serving Size: One Gelcap

Amount Per Serving

%DV

Vitamin E (as d-Alpha Tocopherol from 1,000 mg Mixed Tocopherols)

335 mg

2,233%

The product is found useful for the following medical conditions

Biochemical and Clinical Effects of Vitamin E Supplementation in Hungarian Smith-Lemli-Opitz Syndrome Patients.

Most Relevant Research

We explored the effects of vitamin E supplementation on patients with Smith-Lemli-Opitz Syndrome (SLOS), particularly focusing on symptoms like eczema. In a three-year study, six patients who were already on dietary cholesterol treatment received vitamin E. Their vitamin E levels were initially low, but following supplementation, all patients showed a significant increase in plasma vitamin E concentrations.

Among the various symptoms assessed, including aggression, irritability, and skin issues like eczema, some patients reported improvements. Our findings indicated that three out of the six patients experienced a reduction in symptoms, including skin photosensitivity and eczema. Notably, those who responded best to therapy had lower baseline ratios of certain cholesterol-related compounds.

While the study suggests that vitamin E could provide benefits to SLOS patients—possibly contributing to improvements in skin conditions like eczema—individual responses varied. Thus, vitamin E supplementation may be worth considering in the management of SLOS, especially for those with low initial vitamin E levels and certain biochemical markers.

9.5

Very effective treatment

Most Useful Review

This has significantly improved my skin, especially for eczema. Alongside Rosita cod liver oil, it has cleared my severe eczema. I've run out, and I'm quickly repurchasing, as I've noticed a slight return of the eczema. Highly recommended!

Headache

I take this on an empty stomach with my thyroid medication and have drastically reduced the dosage needed. Other brands caused me severe headaches, but this one does not contain soy, making it very effective and highly recommendable.

Heart Attack

This drug is excellent and effective. It has improved my overall condition after taking it. I have noticed better heart function and reduced inflammation, all helpful factors in more effectively managing the risk of heart attack.

High Cholesterol

Natural skin benefits

Most Useful Review

This supplement has high-quality, natural ingredients that effectively lower high cholesterol. My skin has improved, and I appreciate the large packaging. I've ordered it twice now and find it has a pleasant taste. It contains natural antioxidants that have benefitted my hair as well. I highly recommend it.

Hypertension

Hypertension improvement

Most Useful Review

I've improved my blood pressure from borderline hypertension of 120/81 to a normal 115/75 with just one capsule. It's astounding! I take several Thorne supplements, and this Vitamin E has made the most significant difference. Additionally, I exercise six days a week.

Lung Cancer

I utilise this vitamin E to strengthen my lungs, and it has been very effective. I have successfully reduced my medication. Thank you, Thorne.

Blood Clot

Blood thinning effect

Most Useful Review

This is one of the few Vitamin E products not derived from vegetable oil, specifically soy, which I find detrimental. I take Vitamin E to help thin my blood, particularly as I'm sedentary and wish to avoid blood clots. It works remarkably well for this!

Hot Flashes

SCIENTIFIC SCORE

Questionable

Based on 4 Researches

Vitamin E reduces hot flashes

Curcumin and vitamin E improve hot flashes, lipid profile, and fasting blood glucose without any detrimental effect on the liver and renal function in postmenopausal women: A triple-blind placebo-controlled clinical trial.

Most Relevant Research

We conducted a study with eighty-four postmenopausal women to see how vitamin E affects hot flashes, among other health markers. The participants were divided into three groups and received either Vitamin E, Curcumin, or a placebo for eight weeks.

Our findings revealed that vitamin E significantly reduced the frequency of hot flashes by nearly one-third compared to those taking the placebo. This reduction was accompanied by improvements in several health indicators, including lower serum triglyceride levels and enhanced high-density lipoprotein (HDL) cholesterol.

Furthermore, vitamin E also showed positive effects on liver health markers. Overall, it appears that vitamin E is effective not only in alleviating hot flashes but also in improving some aspects of the lipid profile in postmenopausal women, without adverse effects on liver or kidney function.

9.5

Menopause improvement

Most Useful Review

This really helps with menopause! My hot flashes have much improved!! I highly recommend it!

Leg Cramps

Vitamin E's potential in leg cramps

Are there alternatives to the use of quinine to treat nocturnal leg cramps?

Most Relevant Research

We explored the potential role of vitamin E in treating leg cramps, particularly in populations such as those undergoing dialysis. The study aimed to understand if vitamin E could provide relief from troublesome nocturnal leg cramps—an issue that many individuals face.

While the effects of quinine, a common treatment, have been closely scrutinized, vitamin E emerges as a noteworthy alternative. Although large-scale randomized controlled trials focusing specifically on vitamin E for leg cramps are limited, some data suggest that it may hold promise for alleviating symptoms. This is especially true for those who might not respond to other treatments.

We observed that incorporating vitamin E could be a safer option, as this supplement generally has a more favorable safety profile compared to quinine. However, it's important to underscore that patients should consider exploring other treatments before turning to quinine, particularly given the latter's potential side effects.

Provides confidence

Most Useful Review

Awesome! I feel confident, and my leg cramps disappear when I use this product.

Autoimmune Disorder

Thorne's quality remains high. I feel my body is inflamed, and I often suffer from canker sores and fatigue, although I still crave sweets. This is my third order from iHerb and my first with reasonably priced supplements. Previously, I reacted poorly to additives. To effectively manage an autoimmune disorder, I believe one needs quality supplements. Remarkably, a longstanding condition has gradually improved. I can enjoy the gel without worry, and its beautiful shine indicates good quality.

Cancer

SCIENTIFIC SCORE

Moderately Effective

Based on 9 Researches

Gamma-tocopherol in cancer research

Gamma-Tocopherol: A Comprehensive Review of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties.

Most Relevant Research

We examined the effects of gamma-tocopherol, a major form of vitamin E, on cancer treatment and prevention. This powerful antioxidant is noted for its ability to combat oxidative stress, which plays a significant role in the development and progression of various cancers.

In several studies, we observed that gamma-tocopherol not only neutralizes harmful reactive oxygen species but also exhibits anti-inflammatory properties. These characteristics help reduce chronic inflammation tied to cancer risks. Furthermore, it has shown the potential to inhibit tumor growth, induce cancer cell death, and restrict blood vessel formation that tumors require to grow.

Specifically, findings indicated that gamma-tocopherol is particularly effective in cancers such as prostate, lung, and colon. With promising results from both preclinical and clinical trials, there is a growing interest in how this natural compound can be beneficial in cancer management.

While we noted excellent tolerance at normal doses, it’s essential to consider careful monitoring at higher levels to avoid any adverse effects. Hence, we believe that ongoing research and advancements in drug delivery methods could further enhance its effectiveness.

8.8

Reduced hot flushes

Most Useful Review

My husband receives three-monthly hormone injections for his secondary cancer and takes three Ultimate-E gelcaps daily. He is pleased with the reduction in hot flushes.

Common Cold

I have been taking this supplement for a short time and have already noticed an improvement in my immune system. I caught a viral illness, likely the most prevalent virus of 2020, and recovered almost without noticing. The only symptoms were a slight stuffy nose and general weakness, which passed in two days. Previously, a common cold would linger longer. I doubled my dose during this period and found my strength remained, with no residual weakness. Overall, I’m pleased with the supplement's quality and capsule size.

Liver Disease

Liver protection benefits

Most Useful Review

I acquired this for pre-alcohol consumption. I've trusted Thorne for years, knowing they have in-house labs for testing. I recently heard a Huberman Lab podcast explaining how taking vitamin E before or shortly after alcohol can mitigate the negative impacts on our liver, so I'm giving it a try!

Menopause

SCIENTIFIC SCORE

Moderately Effective

Based on 3 Researches

Vitamin E enhances vaginal health

Retrospective Investigator-Initiated Trial on Tocopherol Acetate Vaginal Administration in Pre-and Postmenopausal Women.

Most Relevant Research

We examined how tocopherol acetate, commonly known as vitamin E, affects vaginal health in women experiencing menopause and those who are premenopausal. The study involved 50 women, split into two groups: 28 postmenopausal and 22 premenopausal, who were assessed before and after a two-week treatment with tocopherol acetate ovules.

After the treatment period, we observed significant improvements in the bothersome symptoms associated with vaginal atrophy, such as dryness, itching, and discomfort during intercourse. Participants reported a noticeable difference in their vaginal health post-treatment, which is quite encouraging. Additionally, a molecular analysis indicated a positive change in the vaginal microbiota, particularly among the premenopausal group, suggesting that vitamin E can help foster a healthier vaginal environment.

Overall, our findings support the potential benefits of using tocopherol acetate for enhancing vaginal well-being during menopause. This could offer a natural alternative for women seeking relief from menopausal symptoms, improving their quality of life during this transitional phase.

8.8

Supports menopause well

Most Useful Review

Easy to swallow and of good quality. Vitamin E is a powerful antioxidant that protects cells from free radicals, which I find particularly important during menopause.

Prostate Cancer

Gamma-tocopherol and prostate cancer

Gamma-Tocopherol: A Comprehensive Review of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties.

Most Relevant Research

We dove into the fascinating realm of gamma-tocopherol, a key form of vitamin E, to understand its impact on prostate cancer treatment. Research indicates that gamma-tocopherol possesses strong antioxidant and anti-inflammatory properties, which could potentially translate into benefits for those facing prostate cancer.

Specifically, we observed that gamma-tocopherol neutralizes harmful reactive oxygen and nitrogen species in the body. This action not only protects cells from oxidative damage but also helps reduce chronic inflammation, a factor often linked to cancer progression.

What truly caught our attention was gamma-tocopherol's multifaceted role in cancer therapy. Evidence suggests that it may inhibit tumor growth, induce apoptosis (the process of programmed cell death), and even suppress the formation of new blood vessels that tumors require to grow. This makes it particularly interesting for managing prostate cancer, alongside its impact on other cancers.

Despite this promising profile, we find that high doses of gamma-tocopherol require careful consideration to avoid potential adverse effects. Overall, while gamma-tocopherol shows potential in understanding and managing prostate cancer, further research is necessary to fully grasp its effectiveness in clinical settings.

8.8

Reduced hot flushes

Most Useful Review

My husband receives hormone injections every three months for his secondary prostate cancer. He takes three Ultimate-E gelcaps daily and is pleased with the reduction in hot flushes.

Acne

SCIENTIFIC SCORE

Questionable

Based on 16 Researches

No significant benefit of vitamin E

Vitamin E does not reduce the side-effects of isotretinoin in the treatment of acne vulgaris.

Most Relevant Research

We explored the effectiveness of vitamin E alongside isotretinoin, a common treatment for severe acne. In an investigator-blinded, randomized study involving 82 patients, participants were divided into two groups. One group received isotretinoin alone, while the other combined it with 800 IU of vitamin E, over a period of 16 weeks.

Our main goal was to determine whether vitamin E could reduce the side-effects associated with isotretinoin, which are often bothersome for patients. Throughout the study, we assessed various mucocutaneous side effects, such as facial dryness and redness, as well as changes in serum lipid and liver enzyme levels.

Ultimately, we found no significant difference in the incidence or severity of side effects between the two treatment groups. This indicates that vitamin E did not provide any noticeable benefit when added to isotretinoin therapy for acne vulgaris.

While vitamin E is often suggested as a remedy to lighten the side effects of medications, our findings suggest that its use alongside isotretinoin may not be helpful.

Stopped due to acne

Most Useful Review

High dosage didn't fit, and I developed allergies along with minor acne. I had to stop taking it.