Vital Proteins Collagen Peptides

In our exploration of how certain natural compounds can impact rheumatoid arthritis (RA), we focused on the total flavonoids derived from Schltr., specifically identifying the effects of quercetin. Our research employed various methods, including cellular and animal models, to examine how these compounds inhibit TNF-α, a key player in inflammation and joint deterioration.

We discovered that quercetin stands out among several compounds, demonstrating a strong ability to reduce TNF-α activity. This reduction corresponds with decreased cellular injury and apoptosis in our models, showcasing quercetin's potential as a protective agent against RA symptoms. Through advanced techniques such as molecular docking and thermal profiling, we verified that quercetin binds to TNF-α, eventually diminishing the inflammatory processes related to arthritis.

The findings suggest that quercetin plays a significant role in suppressing the TNF-α/NF-κB signaling pathway, which is crucial in the development of RA. By blocking certain inflammatory responses, quercetin appears to mitigate pain and joint damage, positioning it as a hopeful candidate for RA treatment. Overall, our investigation highlights quercetin's promising properties as a natural anti-inflammatory agent for those suffering from arthritis.

Significant pain reduction

Most Useful Review

I have experienced severe joint pain in my left hip, lower back, and neck for years, suspected to be due to arthritis. I take Arthrotec daily, which offers only temporary relief. After trying the Vitals Protein based on reviews, I can hardly believe the difference! No more hip or back pain, I sleep much better, have more energy, and improved digestion. While my weight hasn't changed, I do mix one scoop into my hot coffee every morning, and there’s no aftertaste. This product has worked so well that I’ve added it to my Amazon subscription list.

Back Pain

Finally hip pain relief! I had severe joint pain in my left hip, lower back, and neck for quite some time. My doctor suggested it's arthritis. I tried Vitals Protein after reading reviews, and the difference has been remarkable. I no longer experience hip or back pain, sleep better, and have more energy. I simply add one scoop to my hot coffee every morning. It’s unflavoured, with no aftertaste. This product works so well that I’ve added it to my Amazon subscription list.

Acne

SCIENTIFIC SCORE

Moderately Effective

Based on 11 Researches

Microneedling depth impacts scars

Evaluation of microneedling depth of penetration in management of atrophic acne scars: a split-face comparative study.

Most Relevant Research

In our exploration of treating atrophic acne scars, we focused on the effects of different microneedling depths using Dermapen. We designed a split-face study involving 14 individuals, where each side of their face received a different treatment depth over six sessions, spaced two weeks apart.

On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.

The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.

Reduced acne significantly

Most Useful Review

Great protein powder with a neutral taste. I started using this about 4 months ago. It mixes easily into a hot drink (less so into a cold drink) and has a neutral flavour. I add it to my coffee each morning, and I can't tell there's anything extra added. During workouts, it provides a calorie boost. My skin has greatly improved, and I experience less acne than before. I've also adapted my diet and increased my water intake, so the enhancement likely stems from various changes.

Bruise

SCIENTIFIC SCORE

Likely Very Effective

BM-MSCs enhance bruise healing

Bone Marrow Mesenchymal Stem Cells Promote Repairing the Bruised Tissue via Regulating mRNA Expression of Molecular Biomarkers and the Apoptotic Rate.

Most Relevant Research

We set out to understand how bone marrow mesenchymal stem cells (BM-MSCs) could assist in the healing of bruises. Our study involved 78 male albino rats, divided into three groups to test the effectiveness of these stem cells on bruise recovery. One group received BM-MSCs, while others did not, allowing us to observe the differences in healing outcomes.

The results were promising. Through subcutaneous injections of BM-MSCs, we noted a significant decrease in the color intensity of bruised skin. This change suggested improved healing, attributed to notable increases in critical molecules like TGF-β and TNF-α, which play essential roles in tissue repair. Additionally, there was a reduction in markers linked to cell death, indicating that the BM-MSCs likely aided in preserving cells in the bruised area.

By analyzing the expression rates of various proteins and RNA markers, we confirmed that these stem cells enhance the healing process, reducing inflammation and apoptosis in the bruised tissue. Overall, BM-MSCs represent a fascinating advancement in promoting recovery from bruises by fine-tuning the balance of important biological processes.

8.8

Faster healing

Most Useful Review

MUST BUY. I drink this in hot tea every morning. I've noticed my skin looks healthier, and at 63, my bruises disappear quicker. My back pain has also improved since I started this routine, which is something I highly recommend!

Cancer

SCIENTIFIC SCORE

Moderately Effective

Based on 9 Researches

METTL14 modifications impact AML

Specific sDMA modifications on the RGG/RG motif of METTL14 regulate its function in AML.

Most Relevant Research

We explored how specific changes to the METTL14 protein affect cancer, particularly in acute myeloid leukemia (AML). By examining the RG-rich region of METTL14, we discovered that a special form of arginine methylation called symmetric dimethylation, specifically at positions R425 and R445, plays a vital role in enhancing its function.

Our research revealed that this modification not only improves the activity of the METTL3:METTL14 complex but also influences which genes get expressed in cancer cells. We found that the presence of symmetric dimethylarginines helps the complex deposit a crucial chemical mark, known as m6A, on RNA, which is essential for the regulation of gene activity.

Furthermore, we conducted a series of experiments that indicated a potential therapeutic angle in targeting the METTL3 and PRMT5 proteins. When both are inhibited, we observed a significant drop in the expression of genes important for AML cell growth, hinting at new possibilities for treating this challenging cancer. Overall, this study highlights the intricate relationship between protein modifications and cancer biology, emphasizing the potential for more targeted approaches in therapy.

8.8

Joint support

Most Useful Review

I felt the difference! Initially sceptical, I have cancer and arthritis. After just two months on this supplement, I noticed a remarkable change. It is completely flavourless, so I mix it into my coffee every morning and have started gifting it to family and friends suffering from joint pain or brittle nails/hair. Highly recommend!

Hair Loss

SCIENTIFIC SCORE

Likely Very Effective

Based on 3 Researches

Collagen promotes pet hair health

Nutrients regulation of skin cells from canines and cats via Wnt/β-catenin signaling pathway.

Most Relevant Research

We explored the effects of specific nutrients on hair loss in pets, particularly focusing on canines and cats. Our research highlighted the Wnt/β-catenin signaling pathway, which is crucial for hair regeneration. We found that collagen, particularly in the form of fish collagen peptides, plays an important role in promoting hair health.

In our study, we noted that keratin hydrolyzed and egg yolk lecithin, along with fish collagen peptides, can significantly boost the movement of β-catenin into the nucleus of skin cells. This process is essential for activating genes that are vital for hair regeneration.

Considering the impact of nutritional balance on pet health, our findings suggest that incorporating these nutrients into a pet's diet could provide an effective strategy for addressing hair loss. By enhancing the expression of target genes linked to hair regeneration, we observed that collagen and other related nutrients may offer a promising avenue for maintaining healthy fur in our furry friends.

6.8

Improved hair texture

Most Useful Review

This is the best brand! After starting this supplement, I noticed my hand pain and stiffness reduced. I recommended it to my girlfriend, who suffers from hair loss; she has observed a distinct improvement in her hair texture and thickness. Missing one star for the price—it's a bit steep—but I only need one scoop a day for results!

Knee Pain

SCIENTIFIC SCORE

Moderately Effective

Based on 4 Researches

CNP may ease knee osteoarthritis

C-type natriuretic peptide suppresses VEGFa gene expression by attenuating IL6-STAT3 signal pathway in primary synovial fibroblasts from rat knee.

Most Relevant Research

We explored the potential of C-type natriuretic peptide (CNP) as a treatment for knee pain and osteoarthritis. This peptide was tested through intraarticular injections in a rat model of knee arthritis to assess its impact on cartilage degradation and persistent pain.

Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.

The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.

9.5

Reduces joint pain

Most Useful Review

The lack of smell is great, and I use it daily. The product's quality is very high and yields amazing benefits. It moisturises incredibly and has a fantastic effect on my skin and knees. It even helps reduce weaknesses and improves my overall health while being sweet to taste.

Pelvic Pain

Excellent and suitable for joint pain. I noticed a significant difference after use. Praise be!