Supplement Facts
Serving Size:
Amount Per Serving
%DV
†Daily Value not established.
The product is found useful for the following medical conditions
High Cholesterol details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.7
9
Effective sleep aid
Most Useful Review
1 people found this helpful
It worked! I hadn't fallen asleep since I was a baby, and even when I became a junior high school student, it didn't change. I was hesitant to go to the clinic as I only thought of sleeping pills, but I read this review and anticipated buying it. Since it is small, I tried using 2 tablets instead of the prescribed 3. Taken an hour before bed, I felt drowsy within 30 minutes. I didn't get to bed immediately, but 30 minutes later, I fell asleep in about 10 minutes. I think it truly works as I fell asleep so smoothly.
Updated: Mar 2026
Atrial Septal Defect details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 25 Reviews
8.6
9
Emotional regulation
Most Useful Review
3 people found this helpful
I use this as a sleep aid for my daughter, who has been diagnosed with both Autism and ADHD, alongside an atrial septal defect. Without melatonin, it took her 2-3 hours to fall asleep, but this product helps her do so within 1 hour. She now enjoys an additional 1-2 hours of sleep, enhancing her emotional regulation throughout the day.
Updated: Apr 2025
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
USERS' SCORE
Good
Based on 7 Reviews
8.6
9.5
We explored how melatonin-based treatments, particularly agomelatine, can affect headaches, focusing on hypnic headaches (HH). This form of headache typically occurs during sleep, disrupting the rest of those affected. A fascinating case of a 58-year-old woman who experienced these nocturnal headaches for three years demonstrated the potential benefits of agomelatine.
After being prescribed 25 mg of agomelatine at bedtime, she reported an impressive 80% reduction in headache frequency and severity within a month. Remarkably, her headaches completely resolved after three months, allowing her to discontinue the medication.
This case highlights the importance of exploring prophylactic treatments aimed at reducing nighttime awakenings caused by HH. Given the significant impact these headaches can have on sleep quality in older populations, treatments that target melatonin receptors could offer a promising avenue for relieving this condition.
After being prescribed 25 mg of agomelatine at bedtime, she reported an impressive 80% reduction in headache frequency and severity within a month. Remarkably, her headaches completely resolved after three months, allowing her to discontinue the medication.
This case highlights the importance of exploring prophylactic treatments aimed at reducing nighttime awakenings caused by HH. Given the significant impact these headaches can have on sleep quality in older populations, treatments that target melatonin receptors could offer a promising avenue for relieving this condition.
9
Effective sleep aid
Most Useful Review
2 people found this helpful
I absolutely adore this product! It remarkably improves my sleep, and I wake up without a headache. The flavour is delightful, and I genuinely believe it contains real melatonin - unlike other brands. I highly recommend it for adults (I’m 30)! I plan to purchase more now because this 1 mg melatonin works like 5 mg from other companies. It also alleviates my eczema on my palms. Thank you!
Updated: Apr 2026
Adhd details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.9
USERS' SCORE
Good
Based on 63 Reviews
8.5
8
We explored how bright light therapy (BLT) can influence ADHD symptoms, especially in individuals with sleep-wake rhythm delays. The study involved participants undergoing standard treatments along with two weeks of morning BLT, which successfully advanced melatonin release and sleep timing.
As a result, we observed a significant reduction in ADHD symptoms, particularly in hyperactivity and impulsivity. Although the therapy did not change sleep quality significantly, it highlighted potential as a complementary approach to traditional ADHD treatments.
This study marks an encouraging step in finding effective alternatives for managing ADHD symptoms.
As a result, we observed a significant reduction in ADHD symptoms, particularly in hyperactivity and impulsivity. Although the therapy did not change sleep quality significantly, it highlighted potential as a complementary approach to traditional ADHD treatments.
This study marks an encouraging step in finding effective alternatives for managing ADHD symptoms.
9
Improved sleep routine
Most Useful Review
1 people found this helpful
Amazing! We use these for my 7-year-old who has adhd and finds it difficult to wind down at night. This, along with a calm bedtime routine, helps him fall asleep at a reasonable time instead of staying up for hours. This was also recommended by his paediatrician as they're half the cost of prescription tablets.
Updated: Jul 2026
Autism details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.2
USERS' SCORE
Good
Based on 15 Reviews
8.5
8
We investigated the role of melatonin in enhancing synaptic development in mouse models of autism. Through long-term oral administration over 28 days, melatonin improved social interactions and dendritic spine density in genetically modified mice.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
9
Improved sleep routine
Most Useful Review
17 people found this helpful
My child (9 years old) with autism spectrum disorder has struggled with sleep issues since he was small. After researching, I discovered that melatonin aids sleep disorders and decided to try it. Initially hesitant, my child soon appreciated the effects and now willingly takes the supplement! Previously, he would stay up until midnight, but within a week of taking it, he could sleep by 10 pm. I'm truly delighted with this purchase! Thank you!
Updated: Jun 2026
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7
USERS' SCORE
Good
Based on 14 Reviews
8.4
9
Melatonin reduces pediatric anxiety, pain
We focused on the effects of oral melatonin on anxiety and pain in children during the stressful process of venipuncture. In a double-blind, randomized controlled trial, we found that administering 0.5 mg/kg of melatonin 30 minutes before the procedure significantly reduced both pain and anxiety levels compared to a placebo.
The results showed that only 18.8% of the kids receiving melatonin reported pain, while 78.2% in the placebo group did. Furthermore, anxiety affected 44.6% of the melatonin group compared to 94.1% of those in the control group.
While melatonin appeared to improve experiences during venipuncture, its impact on the success rate was not statistically significant.
The results showed that only 18.8% of the kids receiving melatonin reported pain, while 78.2% in the placebo group did. Furthermore, anxiety affected 44.6% of the melatonin group compared to 94.1% of those in the control group.
While melatonin appeared to improve experiences during venipuncture, its impact on the success rate was not statistically significant.
9
Restlessness reduced
Most Useful Review
Great! An excellent way to help your child fall asleep quickly and enjoy sound sleep. The restlessness and anxiety during night sleep have disappeared, and I no longer wake up frequently throughout the night.
Updated: Jun 2026
Chronic Cough details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.4
9
Helps sleep quality
Most Useful Review
It is simply wonderful. I use it for both myself and my children to assist with sleep, particularly during my period, and it helps my children rest and alleviates their chronic cough. God willing, I will order a second bottle.
Updated: Apr 2026
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Quick sleep solution
Most Useful Review
Sleep without hind legs. It really helps! Thirty minutes after taking the pill, my daughter sleeps soundly. It works from the very first evening. The taste is pleasant; she even asks for them. It has become a ritual – she reminds me before her shower, calling them "vitamins." Previously, she would toss and turn for an hour and sleep restlessly, but now, at most, it takes her 15 minutes to fall asleep, and she sleeps all night.
Updated: Apr 2025
Ear Infection details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 8 Reviews
8.3
8
Our study examined the effects of melatonin on oxidative stress in ear infections, using guinea pigs. We divided them into four groups—one control group, one receiving histamine to induce ear infection, and two groups pretreated with either melatonin or methylprednisolone before infection onset.
We found that melatonin significantly reduced oxidative stress markers compared to untreated infections. While both treatments helped, melatonin showed a more pronounced protective effect against infection-related damage. This suggests that melatonin could be a promising option for managing ear infections through its antioxidant capabilities.
We found that melatonin significantly reduced oxidative stress markers compared to untreated infections. While both treatments helped, melatonin showed a more pronounced protective effect against infection-related damage. This suggests that melatonin could be a promising option for managing ear infections through its antioxidant capabilities.
9
Quick sleep onset
Most Useful Review
1 people found this helpful
I purchased this for my 8-year-old. During holidays, she struggles to sleep when she wakes up late. After extensive research, I found this supplement. It astonished me that she could fall asleep 30 to 40 minutes after taking it, which is vital on exciting days, like during travel. Though the label suggests 2 tablets for her age, one suffices. I prefer this tablet form for travelling as it’s easier to take.
Updated: Jun 2026
Heart Disease details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.3
7.5
Supports heart health
Most Useful Review
The quality of iHerb products is excellent, with all-natural ingredients that promote health. The convenient packaging is suitable for all ages. It is made solely from clean fish, which reduces inflammation and benefits heart disease. My hair has become thicker, and the ends no longer split.
Updated: Mar 2026
Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.8
USERS' SCORE
Good
Based on 7 Reviews
8.1
9
Melatonin mitigates banana cold injury
We explored how melatonin treatment affects chilling injury in bananas during cold storage. The study revealed that bananas treated with 500 μmol L of melatonin significantly reduced the signs of chilling injury compared to untreated control fruits during 96 hours of storage.
We observed notable changes in the activity of reactive oxygen species (ROS) metabolism. The melatonin-treated bananas showed lower rates of ROS production while also displaying higher levels of beneficial compounds like ascorbic acid and glutathione. Furthermore, the treatment helped maintain the activity of key antioxidant enzymes that typically decline under cold stress.
A thorough analysis of gene expression found 1858 differentially expressed genes, indicating how melatonin influences various biological pathways in the fruit. Interestingly, melatonin seems to boost the expression of antioxidant enzyme genes while inhibiting the expression of a gene responsible for ROS production.
Overall, these findings provide valuable insights into how melatonin can effectively mitigate cold-related injuries in bananas, helping preserve their quality during storage.
We observed notable changes in the activity of reactive oxygen species (ROS) metabolism. The melatonin-treated bananas showed lower rates of ROS production while also displaying higher levels of beneficial compounds like ascorbic acid and glutathione. Furthermore, the treatment helped maintain the activity of key antioxidant enzymes that typically decline under cold stress.
A thorough analysis of gene expression found 1858 differentially expressed genes, indicating how melatonin influences various biological pathways in the fruit. Interestingly, melatonin seems to boost the expression of antioxidant enzyme genes while inhibiting the expression of a gene responsible for ROS production.
Overall, these findings provide valuable insights into how melatonin can effectively mitigate cold-related injuries in bananas, helping preserve their quality during storage.
9
Strong immunity boost
Most Useful Review
These excellent vitamins, consumed since January, have clearly made a difference. I no longer feel constantly fatigued, and my energy levels have risen, benefiting both my daily activities and sports. My immunity has strengthened—I haven’t caught a cold amidst the winter months. The long-lasting dosage allows for less frequent consumption, contributing positively to my health.
Updated: Apr 2025
Sleep Apnea details
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.6
USERS' SCORE
Good
Based on 33 Reviews
8.1
9.5
Melatonin improves sleep apnea outcomes
We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
8
Improved sleep regulation
Most Useful Review
7 people found this helpful
Excellent! It is a mauve pill that tastes like small berries. I took it after having twin girls when their sleeping patterns were disrupted. Thankfully, it helped me regulate their sleep. I give them half a pill; they enjoy it as if it's a sweet and drink a bit of water with it. They are healthy and well. I don't use it daily but rather when needed, like when they are restless or tired. My daughters are now 4 years old. I hope this helps you.
Updated: Apr 2026
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.7
8
Melatonin improves MS-related symptoms
We explored the impact of melatonin on patients with multiple sclerosis (MS), aiming to improve heart function and sleep. In a randomized controlled trial, participants received either melatonin or a placebo for 12 weeks.
We observed significant improvements in heart rate variability and markers of oxidative stress, suggesting that melatonin could enhance heart health and lower stress in MS patients. Additionally, sleep quality and quantity also improved with melatonin use.
This study indicates that melatonin might be a beneficial treatment option for managing cardiac issues and sleep disturbances in MS.
We observed significant improvements in heart rate variability and markers of oxidative stress, suggesting that melatonin could enhance heart health and lower stress in MS patients. Additionally, sleep quality and quantity also improved with melatonin use.
This study indicates that melatonin might be a beneficial treatment option for managing cardiac issues and sleep disturbances in MS.
7.5
Game changer
Most Useful Review
After years of bedtime hassles, my son's occupational therapist recommended melatonin. We tried everything, but this was a game changer. He can only manage a quarter of a chewable tablet to avoid emotional reactions the next day, but it has significantly improved his sleep.
Updated: Mar 2026
Insomnia details
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.8
USERS' SCORE
Moderately Good
Based on 19 Reviews
7.6
9
We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
10
Restored sleep routine
Most Useful Review
2 people found this helpful
Thank you; you saved us! My 11-year-old struggle with terrible insomnia, but after using these tablets for five days, she has normalised her sleep. The delightful grape smell and flavour are bonus perks!
Updated: Jun 2026
Data last updated:
