Supplement Facts
Serving Size:
Amount Per Serving
%DV
†Daily Value not established.
The product is found useful for the following medical conditions
Adhd details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 69 Reviews
9
9.5
Silence at last
Most Useful Review
The product really works! My son has ADHD and takes ages to sleep. After giving him this, silence returns within 30 minutes, and everyone sleeps peacefully through the night. It’s fantastic as we wake up easily now!
Autism details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 18 Reviews
9
8.8
Sleep onset improvement
Most Useful Review
What can I say? This melatonin truly helps! My son has autism and consequently struggles with sleep. Since giving him this melatonin, he falls asleep within 30 minutes. I follow a specific routine, putting him to bed and administering the melatonin while keeping the room dark. It's been two weeks now; I'm considering a break from it. I took it upon my doctor's recommendation, and I appreciate that it’s non-addictive!
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
USERS' SCORE
Good
Based on 8 Reviews
8.9
9.5
Agomelatine relieves hypnic headaches
Case report: Hypnic headache responds to agomelatine-a potential prophylactic treatment option.
Most Relevant Research
We explored how melatonin-based treatments, particularly agomelatine, can affect headaches, focusing on hypnic headaches (HH). This form of headache typically occurs during sleep, disrupting the rest of those affected. A fascinating case of a 58-year-old woman who experienced these nocturnal headaches for three years demonstrated the potential benefits of agomelatine.
After being prescribed 25 mg of agomelatine at bedtime, she reported an impressive 80% reduction in headache frequency and severity within a month. Remarkably, her headaches completely resolved after three months, allowing her to discontinue the medication.
This case highlights the importance of exploring prophylactic treatments aimed at reducing nighttime awakenings caused by HH. Given the significant impact these headaches can have on sleep quality in older populations, treatments that target melatonin receptors could offer a promising avenue for relieving this condition.
After being prescribed 25 mg of agomelatine at bedtime, she reported an impressive 80% reduction in headache frequency and severity within a month. Remarkably, her headaches completely resolved after three months, allowing her to discontinue the medication.
This case highlights the importance of exploring prophylactic treatments aimed at reducing nighttime awakenings caused by HH. Given the significant impact these headaches can have on sleep quality in older populations, treatments that target melatonin receptors could offer a promising avenue for relieving this condition.
9.5
No headache
Most Useful Review
I use it myself when having trouble falling asleep. It gently helps me drift into slumber, with an excellent dosage. After taking it, there is no headache. Just half or even a third of a tablet suffices for a child.
High Cholesterol details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.9
9.5
Effective sleep aid
Most Useful Review
It worked! I hadn't fallen asleep since I was a baby, and even when I became a junior high school student, it didn't change. I was hesitant to go to the clinic as I only thought of sleeping pills, but I read this review and anticipated buying it. Since it is small, I tried using 2 tablets instead of the prescribed 3. Taken an hour before bed, I felt drowsy within 30 minutes. I didn't get to bed immediately, but 30 minutes later, I fell asleep in about 10 minutes. I think it truly works as I fell asleep so smoothly.
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7
USERS' SCORE
Good
Based on 18 Reviews
8.8
9
Melatonin reduces pediatric anxiety, pain
The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial.
Most Relevant Research
We focused on the effects of oral melatonin on anxiety and pain in children during the stressful process of venipuncture. In a double-blind, randomized controlled trial, we found that administering 0.5 mg/kg of melatonin 30 minutes before the procedure significantly reduced both pain and anxiety levels compared to a placebo.
The results showed that only 18.8% of the kids receiving melatonin reported pain, while 78.2% in the placebo group did. Furthermore, anxiety affected 44.6% of the melatonin group compared to 94.1% of those in the control group.
While melatonin appeared to improve experiences during venipuncture, its impact on the success rate was not statistically significant.
The results showed that only 18.8% of the kids receiving melatonin reported pain, while 78.2% in the placebo group did. Furthermore, anxiety affected 44.6% of the melatonin group compared to 94.1% of those in the control group.
While melatonin appeared to improve experiences during venipuncture, its impact on the success rate was not statistically significant.
9.5
Promotes better sleep
Most Useful Review
Works great! My 7-year-old has nighttime anxiety and often can't settle before bed. On nights when his mind races with worries, these supplements help him relax so that he falls asleep before the anxieties can return. Previously, he managed only 5-6 hours of sleep from constant waking, but now that's changed. I give it to him consistently for better results, and it seems to help regulate his sleep patterns.
Ear Infection details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 19 Reviews
8.8
8
Melatonin reduces oxidative stress
Protective effect of melatonin on experimental otitis media with effusion in guinea pigs.
Most Relevant Research
Our study examined the effects of melatonin on oxidative stress in ear infections, using guinea pigs. We divided them into four groups—one control group, one receiving histamine to induce ear infection, and two groups pretreated with either melatonin or methylprednisolone before infection onset.
We found that melatonin significantly reduced oxidative stress markers compared to untreated infections. While both treatments helped, melatonin showed a more pronounced protective effect against infection-related damage. This suggests that melatonin could be a promising option for managing ear infections through its antioxidant capabilities.
We found that melatonin significantly reduced oxidative stress markers compared to untreated infections. While both treatments helped, melatonin showed a more pronounced protective effect against infection-related damage. This suggests that melatonin could be a promising option for managing ear infections through its antioxidant capabilities.
9.5
Sleep issues resolved
Most Useful Review
Superb! These vitamins addressed two issues! My daughter now falls asleep earlier and faster. Previously, she frequently woke up crying even for toilet breaks. The first night with melatonin, she slept soundly through the night. I felt refreshed waking an hour earlier than usual. She enjoyed the vitamins immediately, relishing the flavour. I also tried one, and within 20 minutes, I felt incredibly drowsy.
Chronic Cough details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.7
9.5
Helps sleep quality
Most Useful Review
It is simply wonderful. I use it for both myself and my children to assist with sleep, particularly during my period, and it helps my children rest and alleviates their chronic cough. God willing, I will order a second bottle.
Heart Disease details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
8.8
Supports heart health
Most Useful Review
The quality of iHerb products is excellent, with all-natural ingredients that promote health. The convenient packaging is suitable for all ages. It is made solely from clean fish, which reduces inflammation and benefits heart disease. My hair has become thicker, and the ends no longer split.
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.6
9.5
Quick sleep solution
Most Useful Review
Sleep without hind legs. It really helps! Thirty minutes after taking the pill, my daughter sleeps soundly. It works from the very first evening. The taste is pleasant; she even asks for them. It has become a ritual – she reminds me before her shower, calling them "vitamins." Previously, she would toss and turn for an hour and sleep restlessly, but now, at most, it takes her 15 minutes to fall asleep, and she sleeps all night.
Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.8
USERS' SCORE
Good
Based on 7 Reviews
8.5
9
Melatonin mitigates banana cold injury
Comparative transcriptomic analysis reveals the reactive oxygen species metabolism involving in melatonin-alleviated chilling injury in postharvest banana fruit.
Most Relevant Research
We explored how melatonin treatment affects chilling injury in bananas during cold storage. The study revealed that bananas treated with 500 μmol L of melatonin significantly reduced the signs of chilling injury compared to untreated control fruits during 96 hours of storage.
We observed notable changes in the activity of reactive oxygen species (ROS) metabolism. The melatonin-treated bananas showed lower rates of ROS production while also displaying higher levels of beneficial compounds like ascorbic acid and glutathione. Furthermore, the treatment helped maintain the activity of key antioxidant enzymes that typically decline under cold stress.
A thorough analysis of gene expression found 1858 differentially expressed genes, indicating how melatonin influences various biological pathways in the fruit. Interestingly, melatonin seems to boost the expression of antioxidant enzyme genes while inhibiting the expression of a gene responsible for ROS production.
Overall, these findings provide valuable insights into how melatonin can effectively mitigate cold-related injuries in bananas, helping preserve their quality during storage.
We observed notable changes in the activity of reactive oxygen species (ROS) metabolism. The melatonin-treated bananas showed lower rates of ROS production while also displaying higher levels of beneficial compounds like ascorbic acid and glutathione. Furthermore, the treatment helped maintain the activity of key antioxidant enzymes that typically decline under cold stress.
A thorough analysis of gene expression found 1858 differentially expressed genes, indicating how melatonin influences various biological pathways in the fruit. Interestingly, melatonin seems to boost the expression of antioxidant enzyme genes while inhibiting the expression of a gene responsible for ROS production.
Overall, these findings provide valuable insights into how melatonin can effectively mitigate cold-related injuries in bananas, helping preserve their quality during storage.
9.5
Strong immunity boost
Most Useful Review
These excellent vitamins, consumed since January, have clearly made a difference. I no longer feel constantly fatigued, and my energy levels have risen, benefiting both my daily activities and sports. My immunity has strengthened—I haven’t caught a cold amidst the winter months. The long-lasting dosage allows for less frequent consumption, contributing positively to my health.
Insomnia details
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.8
USERS' SCORE
Good
Based on 26 Reviews
8.4
9
Melatonin delivery enhances sleep
Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation.
Most Relevant Research
We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
8.8
Improved sleep quality
Most Useful Review
Excellent melatonin for children; they achieve deep, restful sleep within 15–30 minutes and wake up in good spirits. Occasionally, my husband and I take three tablets for insomnia as well. The flavour is pleasantly sweet and sour. Initially, I purchased a pack of 30 tablets, but I've now ordered a larger 50 tablet pack. If my review was helpful, please give a thumbs up.
Sleep Apnea details
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.6
USERS' SCORE
Good
Based on 179 Reviews
8.4
9.5
Melatonin improves sleep apnea outcomes
Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial.
Most Relevant Research
We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
9.5
Promotes restful sleep
Most Useful Review
This melatonin effectively helps my child, who struggles with sleep apnea, to fall asleep quickly. The dosage is ideal and in a pleasant chewable form, making it easy for my child to consume. He wakes up refreshed and in a good mood. I highly recommend this melatonin for parents facing similar issues.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Medium or Average
Based on 6 Reviews
6.7
8
Melatonin improves MS-related symptoms
12-week melatonin intake attenuates cardiac autonomic dysfunction and oxidative stress in multiple sclerosis patients: a randomized controlled trial.
Most Relevant Research
We explored the impact of melatonin on patients with multiple sclerosis (MS), aiming to improve heart function and sleep. In a randomized controlled trial, participants received either melatonin or a placebo for 12 weeks.
We observed significant improvements in heart rate variability and markers of oxidative stress, suggesting that melatonin could enhance heart health and lower stress in MS patients. Additionally, sleep quality and quantity also improved with melatonin use.
This study indicates that melatonin might be a beneficial treatment option for managing cardiac issues and sleep disturbances in MS.
We observed significant improvements in heart rate variability and markers of oxidative stress, suggesting that melatonin could enhance heart health and lower stress in MS patients. Additionally, sleep quality and quantity also improved with melatonin use.
This study indicates that melatonin might be a beneficial treatment option for managing cardiac issues and sleep disturbances in MS.
7.5
Game changer
Most Useful Review
After years of bedtime hassles, my son's occupational therapist recommended melatonin. We tried everything, but this was a game changer. He can only manage a quarter of a chewable tablet to avoid emotional reactions the next day, but it has significantly improved his sleep.
