We set out to investigate how zinc might help protect heart cells from damage caused by a lack of blood flow, known as myocardial ischemia-reperfusion injury (MIRI). Using H9C2 cells, which are derived from rat heart tissue, we simulated this injury by depriving these cells of oxygen and then reintroducing it while treating them with zinc.
Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.
Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.
Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.
Sore throat relief
Most Useful Review
8 people found this helpful
I tested this drug at the beginning of November when my throat hurt, which coincided with the receipt of my order. According to the instructions, with initial symptoms of the disease, it is recommended to dissolve up to 6 capsules daily; however, I only took 4. The next day, I was pleased with the result as the sore throat had disappeared. I completed the course over 6 days and recommend it. The tablets are not chewable but meant for resorption.