21st Century B 12

We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.

This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.

Cured anemia

Most Useful Review

I bought this due to severe anaemia. Initially, I took 1500mcg, but it wasn't effective, so I switched to 2500mcg. Blood tests confirm my anaemia has resolved, and I’ve recommended it to my aunt for her neuralgia; she reported reduced pain.

Cardiovascular Disease details

SCIENTIFIC SCORE

Questionable

Based on 10 Researches

Vitamin B status correlates with mortality

Li Y, Wang H, Chen S, Wei Q, Liu Y, et al. The combined indicator of vitamin B status calculated using 3-parameters (3cB) is negatively associated with mortality among US adults: NHANES 1999 to 2004. Nutr Res. 2025;136:53. doi:10.1016/j.nutres.2025.02.008

We examined the role of vitamin B status on mortality rates, focusing on cardiovascular disease. Using data from over 12,000 adults, we found that higher scores on the combined vitamin B status indicator (3cB) were linked to lower risks of dying from cardiovascular issues. Specifically, individuals with lower 3cB scores faced significantly higher risks of mortality. This suggests that maintaining adequate vitamin B levels could potentially play an important part in reducing cardiovascular disease-related deaths.

9.5

Nervous system support

Most Useful Review

Vitamin B12 is vital for my nervous system. After using it, I experienced increased energy, better physical activity, and hair growth without shedding. B12 assists in blood cell division, ensures proper oxygen circulation, and helps eliminate toxic homocysteine, thus contributing to cardiovascular disease prevention. I appreciate the reviews that guided my choice and hope my experience aids others.

Mild Cognitive Impairment details

Enhanced vitality noted

Most Useful Review

Vitamin B12 has been a revelation for me! After purchasing it based on positive reviews, I experienced a surge of energy, improved physical activity, and even healthier hair. This vitamin is crucial for myelin synthesis, which protects nerve fibers and aids signal transmission. I learned that it plays a significant role in blood circulation alongside iron, assisting in red blood cell division, crucial for constant oxygen flow. B12 also helps eliminate harmful homocysteine, protecting blood vessels and potentially preventing conditions like Alzheimer's disease and dementia. Additionally, it supports various functions, including mood and detoxification. If this review helps you, I’m pleased! Thank you to those who support my feedback.

Chronic Fatigue Syndrome details

SCIENTIFIC SCORE

Questionable

Based on 9 Researches

Vitamin B12 ineffective for CFS

Wiebe E. N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports. Can Fam Physician. 1996;42:2214.

We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.

In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.

These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.

9.5

Improved sleep quality

Most Useful Review

In recent years, I have experienced chronic fatigue and nerve tingling, which have impeded my normal work activities. The doctor suggested a higher dosage of vitamin B12, and after over a month, the nerve pain gradually vanished. I now enjoy good sleep quality and feel less fatigued. This is vital for my health. 21st Century B12 is a high-dose and cost-effective product that I will continue to use.

Depression details

SCIENTIFIC SCORE

Possibly Effective

Based on 22 Researches

Vitamin B affects depression risk

Laird EJ, O'Halloran AM, Molloy AM, Healy M, Hernandez B, et al. Low vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. Br J Nutr. 2023;130:268. doi:10.1017/S0007114521004748

We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.

However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.

9.5

Resolved depression

Most Useful Review

Excellent! B12 is a fantastic product that I take alongside folic acid and I'm now fine with depression. I would 100% recommend it. The quality and price are great. It has a pleasant raspberry flavour and aroma. The small pills are easy to swallow. Many thanks to the iHerb team.

Dizziness details

SCIENTIFIC SCORE

Moderately Effective

Based on 22 Researches

B12 treatment improved dizziness symptoms

Cittolin-Santos GF, Khalil S, Bakos JK, Baker K. Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic Anemia. Case Rep Hematol. 2020;2020:8697493. doi:10.1155/2020/8697493

We examined a unique case involving a 28-year-old male who experienced dizziness related to severe anemia from low vitamin B12 levels.

After treatment with daily vitamin B12 injections, his symptoms and lab values significantly improved, indicating a positive response to the treatment.

Despite the rare nature of his condition—seronegative pernicious anemia—the results suggest that B12 can effectively alleviate dizziness stemming from anemia in similar cases.

9.5

Energy restored

Most Useful Review

B-12 is essential! A deficiency leads to constant drowsiness, shortness of breath, and dizziness. B12 protects nerve fibres, ensuring the nervous system functions properly. I used B12 for my anaemia, alongside iron and vitamin C. A month later, my haemoglobin was 131. I felt more energetic, and the drowsiness and dizziness had gone. The taste is pleasantly fruity!

We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.

Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.

9.5

Heart health improved

Most Useful Review

The quality is excellent, with wonderful ingredients and suitable age composition. Fish oil and omega-3 help reduce high cholesterol, increase hair density, and protect the heart from inflammation. I’ve noticed a strengthening effect on my body.

Leg Cramps details

Disappearing leg cramps

Most Useful Review

It's astonishing! The quality and ingredients are excellent, and with 110 tablets, it’s better than pills. I experienced numbness in my hands and legs, but thankfully, that's gone. Folic acid is important, especially for pregnant women. My energy improved significantly, and the metabolism is superb. It tastes great too, much better than swallowing a pill!

Osteoporosis details

SCIENTIFIC SCORE

Questionable

Based on 4 Researches

Vitamin B12 linked to fractures

Li Z, Zheng R, Xue H, Zhu H. Vitamin B12 as a novel risk biomarker of spinal fractures. Medicine (Baltimore). 2022;101:e30796. doi:10.1097/MD.0000000000030796

We explored how vitamin B12 affects spinal fractures in patients with osteoporosis, a condition that significantly increases the risk of these injuries. Our investigation involved 105 participants diagnosed with osteoporosis. We assessed clinical data alongside blood levels of several vitamins, including vitamin B12, to understand their connection to spinal fractures.

Our analysis revealed a substantial relationship between elevated vitamin B12 levels and the incidence of spinal fractures. We found that not only was there a notable association with spinal fractures, but higher vitamin B12 was also linked to a shorter time before a recurrence of fractures occurred. These findings suggest that as vitamin B12 levels rise, the risk for spinal fractures in osteoporosis patients increases, which indicates a potentially serious concern for these individuals.

While vitamin B9 also showed some association, it was vitamin B12 that stood out in both our logistic regression analyses. Overall, our results suggest that monitoring and perhaps addressing vitamin B12 levels could be crucial for managing patients’ health and preventing further complications from osteoporosis.

8.8

Boosts bone health

Most Useful Review

B12 vitamins help produce red blood cells and prevent anaemia. They improve bone health and lower the risk of osteoporosis, while also boosting energy levels. Additionally, B12 aids in protecting the brain against dementia.

Autoimmune Disorder details

SCIENTIFIC SCORE

Possibly Effective

Based on 19 Researches

Pernicious anemia diagnosis and treatment

Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4

We examined a case of a 51-year-old Ugandan man who experienced recurring lower limb weakness linked to pernicious anemia, an autoimmune condition causing vitamin B12 deficiency. After initial treatments, his symptoms reappeared, leading to further testing that confirmed the diagnosis.

Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.

8.3

Effective treatment noted

Most Useful Review

The box is sealed, and the pill is small. I found vitamin B12 effective for my autoimmune disorder, easing mouth ulcers, fatigue, and exhaustion. After a week of use, I noticed a difference and plan to buy more.

Back Pain details

SCIENTIFIC SCORE

Moderately Effective

Based on 22 Researches

B12 alleviates low back pain

Mauro GL, Martorana U, Cataldo P, Brancato G, Letizia G. Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2000;4:53.

We evaluated the effectiveness of intramuscular vitamin B12 in treating low back pain among 60 patients aged 18 to 65 with mechanical pain lasting at least six months.

In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.

Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.

Nervous system support

Most Useful Review

Vitamin B12 is essential for the nervous system, aiding myelin synthesis and enhancing signal transmission. After taking it, I felt a surge of energy and vitality, my endurance improved, and I experienced no illnesses or hair loss. It helps keep homocysteine levels in check, protects blood vessel walls, and supports cardiovascular health, which is crucial for alleviating back pain.

Bone Pain details

Effective pain relief

Most Useful Review

Cool vitamin. After waking up with terrible back pain, it significantly improved by the third day, and by day ten, all pain had vanished. My sleep also improved, although I still take magnesium. The vitamin dissolves quickly under the tongue and has a fruity taste. They truly work, and I didn’t expect such a fast result!

Tinnitus details

SCIENTIFIC SCORE

Questionable

Based on 7 Researches

No significant benefit from B12

Dadgarnia M, Mandegari M, Zand V, Vaziribozorg S, Zare-Zardini H, et al. The effect of vitamin B12 on idiopathic tinnitus. Am J Otolaryngol. 2024;45:104028. doi:10.1016/j.amjoto.2023.104028

We conducted a double-blind clinical trial with 140 patients suffering from idiopathic tinnitus to gauge the effectiveness of vitamin B12. Participants were divided into two groups, one receiving vitamin B12 and the other a placebo over a month.

We evaluated tinnitus severity through questionnaires at multiple intervals. However, our findings revealed that vitamin B12 did not significantly reduce tinnitus severity compared to the placebo.

Ultimately, our study suggests that vitamin B12 may not be a beneficial treatment for tinnitus, as the results showed no noteworthy improvements.

Tinnitus cured

Most Useful Review

My tinnitus has been cured! After suffering from a low-pitched ringing in my ears, I visited an ENT doctor who prescribed me medication. Although I hoped for improvement, it often worsened, leading to frequent visits to the doctor. I tried a new medicine with the same ingredients in larger doses, and it cured my tinnitus within about five days!