' 
Supplement Facts
Serving Size: 1 Soft Gel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
1%**
Cholesterol
<5mg
<2%
Vitamin A (from cod live oil and retinyl palmitate)
27 mcg RAE
3%
Vitamin D (as cholecalciferol) (from cod liver oil and cholecalciferol concentrate)
100 mcg (4,000 IU)
500%
Vitamin E (as d-alpha tocopherol)
0.67 mg
4%
Norwegian Cod Liver Oil
500 mg
†
Total Omega-3 fatty Acids☆
115 mg
†
DHA (Docosahexaenoic Acid)☆
50 mg
†
EPA (Eicosapentaenoic Acid)☆
42 mg
†
The product is found useful for the following medical conditions
Common Cold
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.9
USERS' SCORE
Good
Based on 3 Reviews
8.7
8
Vitamin D reduces cold severity
Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training.
Most Relevant Research
We explored the connection between vitamin D levels and the frequency of upper respiratory tract infections (URTI) in physically active individuals throughout different seasons. In our research, we observed over 1,600 military recruits during their basic training, noting that only 21% were vitamin D sufficient during winter. Alarmingly, those who had sufficient vitamin D levels were found to be 40% less likely to experience URTIs compared to their deficient counterparts, suggesting that maintaining adequate vitamin D may be crucial for better respiratory health during demanding training periods.
Building on these findings, we conducted a follow-up study with 250 recruits, where we implemented various vitamin D supplementation strategies. Participants received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplementation. The results were promising: vitamin D helped alleviate the severity of URTI symptoms and significantly reduced the number of days experiencing a cold. Notably, both sunlight and dietary supplementation were equally effective in boosting vitamin D levels and improving outcomes.
Overall, achieving vitamin D sufficiency can markedly reduce the burden of URTIs, particularly in physically demanding scenarios such as military training.
Building on these findings, we conducted a follow-up study with 250 recruits, where we implemented various vitamin D supplementation strategies. Participants received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplementation. The results were promising: vitamin D helped alleviate the severity of URTI symptoms and significantly reduced the number of days experiencing a cold. Notably, both sunlight and dietary supplementation were equally effective in boosting vitamin D levels and improving outcomes.
Overall, achieving vitamin D sufficiency can markedly reduce the burden of URTIs, particularly in physically demanding scenarios such as military training.
9.5
Effective immunity boost
Most Useful Review
I love that these capsules don't contain lanolin. I've been taking one daily for 15 years, and they have reversed my osteopenia and improved my immune system. Most years, I hardly catch the common cold, perhaps only once. They're essential, and Carlson sources these from the wild with no chemical processing.
Back Pain
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.3
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
Vitamin D aids back pain recovery
An Unusual Mimic of Axial Spondyloarthritis: A Case Report.
Most Relevant Research
We observed a fascinating case involving a male in his 40s who experienced persistent inflammatory back pain for three months. Despite having a negative test for HLA-B27, a marker often associated with axial spondyloarthritis, clinical assessments suggested possible underlying issues.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
9.5
Increased energy levels
Most Useful Review
I'm very pleased! My doctor in Finland recommended this D3 supplement last year for my multiple sclerosis. Since taking one capsule daily, I have more energy and no longer feel tired. Remarkably, my back pain has eased, and I've avoided flu this past year! Previously, migraines required medication weekly, but now those have disappeared. I'm truly grateful for this product.
Breast Cancer
SCIENTIFIC SCORE
Possibly Effective
Based on 51 Researches
7.2
USERS' SCORE
Good
Based on 1 Review
8.6
8
Vitamin D and breast cancer link
Umbrella Review on the Relationship Between Vitamin D Intake and Cancer.
Most Relevant Research
We examined the relationship between vitamin D intake and breast cancer, delving into how this vitamin may play a role in prevention and management. The findings suggest that vitamin D may have a protective effect, potentially lowering the risk of developing breast cancer.
While we found a notable connection, it’s important to recognize that most of the existing evidence comes from observational studies. This means we can identify associations but cannot definitively say that vitamin D causes these effects.
Additionally, there are several complexities in studying vitamin D, such as varying metabolism and differences in study designs, which make drawing firm conclusions challenging.
Although the research provides intriguing insights, more rigorous studies are necessary to truly clarify how vitamin D could be integrated into breast cancer care moving forward.
While we found a notable connection, it’s important to recognize that most of the existing evidence comes from observational studies. This means we can identify associations but cannot definitively say that vitamin D causes these effects.
Additionally, there are several complexities in studying vitamin D, such as varying metabolism and differences in study designs, which make drawing firm conclusions challenging.
Although the research provides intriguing insights, more rigorous studies are necessary to truly clarify how vitamin D could be integrated into breast cancer care moving forward.
9.5
Remarkable improvement
Most Useful Review
Excellent! My wife, diagnosed with breast cancer, has shown remarkable improvement since using products recommended by Dr Antti Heikkilä. She feels stronger and can walk a bit and manage some home tasks. It's almost miraculous, as she now believes she might have more time to live. In November 2010, an oncologist gave her just two months to live, but thanks to Dr Heikkilä's advice and the items from iherb.com, she has gained precious time. Thank you for everything!
Cancer
SCIENTIFIC SCORE
Possibly Effective
Based on 50 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.6
9
Cod liver oil reduces pancreatic tumors
Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression.
Most Relevant Research
Our research explored the effects of cod liver oil, rich in omega-3 fatty acids, on pancreatic cancer using a genetically engineered mouse model. This model mimics human pancreatic cancer biology, allowing us to gain insights relevant to real-world conditions.
We found that a diet supplemented with cod liver oil, which contains eicosapentaenoic acid and docosahexaenoic acid, significantly reduced tumor volume and limited metastasis to the lungs and liver. There was also a notable trend toward improved survival rates among the mice that received this treatment.
Notably, the intake of omega-3 fatty acids led to changes in the tumor’s fatty acid profile and reduced the release of certain inflammatory compounds. While we observed a reduction in malignancy-related characteristics and an increase in cancer cell death, normal cell growth remained unaffected.
Another intriguing finding was the significant decline in tumor fibrosis linked to lower levels of Sonic Hedgehog, a critical component involved in the tumor environment of pancreatic cancer. Overall, our findings highlight how omega-3 fatty acids may serve as a promising dietary intervention in managing pancreatic cancer.
We found that a diet supplemented with cod liver oil, which contains eicosapentaenoic acid and docosahexaenoic acid, significantly reduced tumor volume and limited metastasis to the lungs and liver. There was also a notable trend toward improved survival rates among the mice that received this treatment.
Notably, the intake of omega-3 fatty acids led to changes in the tumor’s fatty acid profile and reduced the release of certain inflammatory compounds. While we observed a reduction in malignancy-related characteristics and an increase in cancer cell death, normal cell growth remained unaffected.
Another intriguing finding was the significant decline in tumor fibrosis linked to lower levels of Sonic Hedgehog, a critical component involved in the tumor environment of pancreatic cancer. Overall, our findings highlight how omega-3 fatty acids may serve as a promising dietary intervention in managing pancreatic cancer.
9.5
Improved health
Most Useful Review
Excellent. My wife has not healed from liver cancer, but the products I ordered from iherb.com, as recommended by our splendid doctor Antti Heikkilä, have made her much better and stronger. She now believes she might have more time to live, despite the oncologist stating in November 2010 that she had only two months left. Thanks to iherb.com and Antti Heikkilä for giving her more time.
Cardiovascular Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 58 Researches
7.2
USERS' SCORE
Good
Based on 5 Reviews
8.6
9
We examined how cod liver oil might influence cardiovascular disease, particularly in relation to atherogenesis and thrombogenesis. Previous observations suggested that eating marine fish can lower the risk of ischemic heart disease. However, the universal recommendation for fish oil as a supplement remains uncertain due to potential side effects associated with high dosages.
Our research revealed that while fish oil lowers cholesterol and triglyceride levels, it can also increase levels of low-density lipoprotein, which raises concerns about free radical generation and bleeding. Interestingly, moderate intake of marine fish has shown protective effects against heart disease without significantly changing traditional measurements like cholesterol levels or blood clotting times.
In a controlled study with swine, we noted that adding cod liver oil to a high-fat diet resulted in fewer monocyte adhesions and platelet clumps in critical heart arteries, suggesting that it plays a role in reducing clotting risks. To delve deeper into the mechanisms, we conducted an in vitro experiment where we treated endothelial cells with varying fatty acids.
Among these, only eicosapentaenoic acid (EPA) stood out in diminishing the binding of human monocytes to the endothelial cells, especially when applied within a specific timeframe after stimulation. Moreover, we found that EPA decreased the expression of certain adhesion molecules on endothelial cells following inflammatory stimulation.
Overall, our findings suggest that cod liver oil could be a potentially valuable addition to heart health strategies, particularly due to its unique ability to influence blood vessel interactions without significant adverse effects.
Our research revealed that while fish oil lowers cholesterol and triglyceride levels, it can also increase levels of low-density lipoprotein, which raises concerns about free radical generation and bleeding. Interestingly, moderate intake of marine fish has shown protective effects against heart disease without significantly changing traditional measurements like cholesterol levels or blood clotting times.
In a controlled study with swine, we noted that adding cod liver oil to a high-fat diet resulted in fewer monocyte adhesions and platelet clumps in critical heart arteries, suggesting that it plays a role in reducing clotting risks. To delve deeper into the mechanisms, we conducted an in vitro experiment where we treated endothelial cells with varying fatty acids.
Among these, only eicosapentaenoic acid (EPA) stood out in diminishing the binding of human monocytes to the endothelial cells, especially when applied within a specific timeframe after stimulation. Moreover, we found that EPA decreased the expression of certain adhesion molecules on endothelial cells following inflammatory stimulation.
Overall, our findings suggest that cod liver oil could be a potentially valuable addition to heart health strategies, particularly due to its unique ability to influence blood vessel interactions without significant adverse effects.
9.5
Strengthens immune system
Most Useful Review
The Vitamin Complex Solar D Gems from Carlson Labs includes vitamin D3, Omega-3 fatty acids, and vitamins A and E. The Omega-3s help my cardiovascular health, brain function, and cholesterol levels. I highly recommend this supplement for overall health as it boosts immunity and aids in managing cardiovascular disease.
Leg Cramps
SCIENTIFIC SCORE
Very Likely Ineffective
Based on 2 Researches
2
USERS' SCORE
Good
Based on 1 Review
8.6
4
We assessed the impact of vitamin D on leg cramps experienced during pregnancy, referring to data from various studies. One of the key findings was that vitamin D treatment showed little to no difference when it came to reducing the frequency of leg cramps.
In a trial involving 84 women, participants who received vitamin D did not see significant changes in the frequency of leg cramps after three weeks or six weeks post-treatment. This suggests that, while vitamin D is often discussed in the context of health benefits, its effectiveness for leg cramps specifically might be quite limited.
Overall, the evidence we reviewed highlights the need for caution. The findings suggest that vitamin D may not be a viable treatment option for managing leg cramps during pregnancy, indicating a need for more robust research in this area.
In a trial involving 84 women, participants who received vitamin D did not see significant changes in the frequency of leg cramps after three weeks or six weeks post-treatment. This suggests that, while vitamin D is often discussed in the context of health benefits, its effectiveness for leg cramps specifically might be quite limited.
Overall, the evidence we reviewed highlights the need for caution. The findings suggest that vitamin D may not be a viable treatment option for managing leg cramps during pregnancy, indicating a need for more robust research in this area.
9.5
Leg cramps relief
Most Useful Review
Wonderful results with high spirits and abundant energy. My sleep returned to normal, and those bothersome leg cramps disappeared. It’s also quite economical, and I took it alongside Omega 3.
Liver Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 49 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Vitamin D improves liver health
Effects of vitamin D supplementation on the glycaemic indices, lipid profile and liver function tests in patients with cirrhosis: a double-blind randomised controlled trial.
Most Relevant Research
We explored the effects of vitamin D supplementation in patients with liver cirrhosis—a progressive disease that often manifests alongside vitamin D deficiency. In a carefully designed study, we involved sixty patients who participated in a double-blind, randomized controlled trial. Each patient received either a weekly dose of 50,000 IU of vitamin D or a placebo over 12 weeks.
Throughout the study, we assessed key health markers before and after supplementation, including liver function tests, lipid profiles, and glycaemic indices such as fasting blood glucose and insulin resistance. By the end of the trial, our findings indicated that vitamin D supplementation significantly improved fasting blood glucose levels and insulin resistance in the participants.
Specifically, we observed noteworthy increases in serum 25-hydroxy-vitamin D levels and reductions in fasting blood glucose and insulin resistance indicators. These results suggest that vitamin D might be an important player in improving metabolic health for those suffering from liver cirrhosis.
Throughout the study, we assessed key health markers before and after supplementation, including liver function tests, lipid profiles, and glycaemic indices such as fasting blood glucose and insulin resistance. By the end of the trial, our findings indicated that vitamin D supplementation significantly improved fasting blood glucose levels and insulin resistance in the participants.
Specifically, we observed noteworthy increases in serum 25-hydroxy-vitamin D levels and reductions in fasting blood glucose and insulin resistance indicators. These results suggest that vitamin D might be an important player in improving metabolic health for those suffering from liver cirrhosis.
9.5
Improved strength
Most Useful Review
Excellent. My wife has advanced liver disease, but the products I ordered from iherb.com, recommended by Dr Antti Heikkilä, have greatly improved her condition and strength. She now believes she may have more time to live. In November 2010, her oncologist predicted she had just two months left. Thanks to Dr Heikkilä's advice, we have found hope and support through these products. Thank you, iherb.com, and a heartfelt thanks to Dr Heikkilä for extending her time with us.
Migraine
SCIENTIFIC SCORE
Possibly Effective
Based on 39 Researches
7.4
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Eicosapentaenoic acid helps migraines
A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine.
Most Relevant Research
We conducted a thorough investigation into how eicosapentaenoic acid (EPA) can impact episodic migraines. In a carefully designed study, we gathered 70 participants who experienced these migraines and divided them into two groups. One group received a high dose of EPA, while the other was given a placebo. This approach ensured that we could see the true effects of EPA without bias.
After 12 weeks, the results were compelling. We noticed that those taking EPA had significantly fewer migraine days compared to the placebo group. In fact, participants on EPA reported an average reduction of 4.4 days per month, while those on the placebo had barely any change. The EPA group also experienced less need for acute headache medication and marked improvements in headache severity, disability, anxiety, depression, and overall quality of life.
Perhaps most striking was how particularly beneficial EPA seemed to be for female participants. Overall, the study demonstrated that high-dose EPA not only helped reduce the frequency and severity of migraines but also positively influenced the psychological aspects of living with migraines.
This suggests that incorporating EPA into migraine management could be a valuable option for those suffering from episodic migraines, especially as there were no major adverse effects reported.
After 12 weeks, the results were compelling. We noticed that those taking EPA had significantly fewer migraine days compared to the placebo group. In fact, participants on EPA reported an average reduction of 4.4 days per month, while those on the placebo had barely any change. The EPA group also experienced less need for acute headache medication and marked improvements in headache severity, disability, anxiety, depression, and overall quality of life.
Perhaps most striking was how particularly beneficial EPA seemed to be for female participants. Overall, the study demonstrated that high-dose EPA not only helped reduce the frequency and severity of migraines but also positively influenced the psychological aspects of living with migraines.
This suggests that incorporating EPA into migraine management could be a valuable option for those suffering from episodic migraines, especially as there were no major adverse effects reported.
9.5
Migraine relief
Most Useful Review
Very pleased! My doctor in Finland recommended this product a year ago for my Multiple Sclerosis. I take one capsule daily and now feel energetic, no longer tired. Remarkably, my pain has diminished, and I haven’t had the flu this year! The migraine, which previously forced me to use medication every week, has ceased. I am incredibly grateful for this improvement!
Multiple Sclerosis
SCIENTIFIC SCORE
Possibly Effective
Based on 51 Researches
7
USERS' SCORE
Good
Based on 3 Reviews
8.6
8
Eicosapentaenoic acid reduces MS symptoms
Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis.
Most Relevant Research
We explored the therapeutic effects of eicosapentaenoic acid (EPA) in tackling multiple sclerosis through a study involving mice with experimental autoimmune encephalomyelitis (EAE). The mice were given diets enriched with or without EPA. Remarkably, the mice that received the EPA-infused diet displayed significantly lower clinical scores compared to those that did not.
Furthermore, we observed that the production of inflammatory markers like IFN-γ and IL-17 was notably reduced in the EPA-treated mice. This reduction is particularly important, as these markers are associated with the progression of multiple sclerosis. Additionally, there was an enhancement in the expression levels of peroxisome proliferator-activated receptors within the CD4T cells infiltrating the central nervous system.
These findings suggest that EPA could serve as a promising new approach to therapy for multiple sclerosis, showcasing its potential in reducing inflammation and improving clinical outcomes in those affected by this condition.
Furthermore, we observed that the production of inflammatory markers like IFN-γ and IL-17 was notably reduced in the EPA-treated mice. This reduction is particularly important, as these markers are associated with the progression of multiple sclerosis. Additionally, there was an enhancement in the expression levels of peroxisome proliferator-activated receptors within the CD4T cells infiltrating the central nervous system.
These findings suggest that EPA could serve as a promising new approach to therapy for multiple sclerosis, showcasing its potential in reducing inflammation and improving clinical outcomes in those affected by this condition.
9.5
Increased energy levels
Most Useful Review
I’m very pleased! My doctor in Finland recommended this product a year ago for my multiple sclerosis. Since then, I've taken one capsule daily, and I feel full of energy, no longer tired as I used to be. Remarkably, my pain has eased and I haven’t had flu all year! My migraines have also vanished; previously, I consumed medication every week. I’m truly satisfied and grateful for this change!
Allergies
SCIENTIFIC SCORE
Possibly Effective
Based on 35 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.5
8
Omega-3s and skin allergies
ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α.
Most Relevant Research
We uncovered intriguing insights into how eicosapentaenoic acid (EPA) and its metabolite, 12-hydroxyeicosapentaenoic acid (12-HEPE), play a role in managing allergic responses, particularly in the skin. Our study revealed that when mice consumed an omega-3 fatty acid-rich diet, 12-HEPE became a significant metabolite in their skin.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
8.8
Improved energy
Most Useful Review
I recommend it. I have become more energetic and resistant to viral diseases, and it does not cause allergies.
Arthritis
SCIENTIFIC SCORE
Possibly Effective
Based on 53 Researches
7.3
USERS' SCORE
Good
Based on 1 Review
8.5
9
Cod liver oil reduces arthritis symptoms
Effect of cod liver oil on symptoms of rheumatoid arthritis.
Most Relevant Research
In a recent study, we examined the effectiveness of cod liver oil in alleviating symptoms of rheumatoid arthritis. Forty-three participants took 1 gram of cod liver oil daily for three months. The results were promising.
We observed significant reductions in morning stiffness, with an impressive 52.4% improvement. Additionally, patients reported a 42.7% decrease in painful joints and a 40% reduction in swollen joints. Pain intensity also saw a notable decline of 67.5%.
When asked about their experience, 68% of patients rated the treatment as "good" or "very good" in terms of effectiveness, and an impressive 95% found it tolerable. While some patients reported nonsevere side effects, three of those reactions might have been linked to the cod liver oil.
Overall, we find that cod liver oil could be a beneficial addition to treatment options for those suffering from rheumatoid arthritis.
We observed significant reductions in morning stiffness, with an impressive 52.4% improvement. Additionally, patients reported a 42.7% decrease in painful joints and a 40% reduction in swollen joints. Pain intensity also saw a notable decline of 67.5%.
When asked about their experience, 68% of patients rated the treatment as "good" or "very good" in terms of effectiveness, and an impressive 95% found it tolerable. While some patients reported nonsevere side effects, three of those reactions might have been linked to the cod liver oil.
Overall, we find that cod liver oil could be a beneficial addition to treatment options for those suffering from rheumatoid arthritis.
8.8
Reduced knee pain
Most Useful Review
My husband's rheumatologist recommended Carlson Vitamin D for his arthritis a few years ago. He suggested I try it too, given my own arthritis, and I've noticed a difference in my painful knee joint. I've since recommended this vitamin to friends as well.
Bone Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Good
Based on 3 Reviews
8.5
9
Vitamin D3 correction improves pain
Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty.
Most Relevant Research
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
9.5
Energy boost
Most Useful Review
I'm very pleased! My doctor in Finland suggested this product a year ago for my multiple sclerosis. Taking one capsule daily has energised me; I no longer feel tired and my pain has subsided. Remarkably, I haven't had flu symptoms this year, and my migraines which previously required medication every week are gone. This product has really changed my life; I am immensely satisfied. Thank you!
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.3
USERS' SCORE
Good
Based on 1 Review
8.5
9.5
Eicosapentaenoic acid benefits CFS
Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes.
Most Relevant Research
We explored the potential benefits of eicosapentaenoic acid (EPA), an essential fatty acid, in treating chronic fatigue syndrome (CFS). A female patient with a six-year history of persistent CFS symptoms participated in the study, receiving a daily supplement rich in EPA.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
9
Increased vitality
Most Useful Review
Super vitamins for us! I recently gave birth and was struggling with chronic fatigue syndrome from lack of sleep and exhaustion. After taking these vitamins, my energy levels improved significantly. I feel more cheerful and stronger! I've even recommended them to all my friends, and they are pleased with the results too. 👍🏻
Heart Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 56 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.5
7
Vitamin D's role in heart health
The Impact of Vitamin D Deficiency on Coronary Artery Disease Severity Based on Myocardial Perfusion Imaging: A Cross-Sectional Study.
Most Relevant Research
We examined how low levels of vitamin D (Vit D) could impact the severity of heart disease, specifically looking at myocardial ischemia. Our study involved two hundred patients who underwent myocardial perfusion imaging at Namazi Hospital in Shiraz, Iran, in 2019. We assessed both the severity of ischemia in patients and their vitamin D levels.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
8.8
Quick recovery
Most Useful Review
I love this vitamin D3, which is in the correct adult dose combined with Omega-3s. My family and I took it, and whenever we got sick, we recovered quickly, thanks to this supplement. I ordered this nearly a year ago and have a few pieces left. I store it in the fridge! It's a great product from a reliable company, and I recommend it wholeheartedly!
Knee Pain
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7
USERS' SCORE
Good
Based on 2 Reviews
8.5
8
Vitamin D3 shows promise for knee OA
The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis.
Most Relevant Research
We explored the potential benefits of vitamin D3 supplementation in alleviating knee pain associated with osteoarthritis (OA). In this open-label clinical trial, we assessed the effects of daily doses of 4000 IU vitamin D3 over three months in 80 patients suffering from knee OA.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
8.8
Reduced knee pain
Most Useful Review
My husband's rheumatologist suggested Carlson Vitamin D several years ago. He asked if I had arthritis, which I do, and recommended I try it too. I have noticed a difference in my knee pain and have shared this vitamin with friends.
Osteoporosis
SCIENTIFIC SCORE
Possibly Effective
Based on 45 Researches
7.4
USERS' SCORE
Good
Based on 1 Review
8.5
9
DHA's role in osteoporosis treatment
Comparative study of DHA-enriched phosphatidylcholine and EPA-enriched phosphatidylcholine on ameliorating high bone turnover regulation of the osteogenesis-related Wnt/β-catenin pathway in ovariectomized mice.
Most Relevant Research
We recently looked into how docosahexaenoic acid (DHA), through its enriched phosphatidylcholine form (DHA-PC), affects osteoporosis. Using a model that simulates the condition in women after ovariectomy, we compared the impact of DHA-PC with eicosapentaenoic acid (EPA) enriched phosphatidylcholine (EPA-PC). Our findings revealed that both DHA-PC and EPA-PC significantly improved the structural quality of trabecular bone, boosted the rate of new bone formation, and elevated bone mineral density, which are crucial factors in combating osteoporosis.
We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.
Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.
We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.
Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.
8.8
Supports bone health
Most Useful Review
Complete D3 and Omega Carlson brand fish oil serves as a vitamin D3 solvent, crafted from quality ingredients. The small, tasteless softgel is easy to swallow, with a dose of 4000 iu meeting daily requirements for teenagers and adults. We face vitamin D deficiency from a lack of sun exposure. Regular intake of Vitamin D enhances immunity, reducing flu occurrences, and also aids in mineral absorption to prevent osteoporosis.
Pelvic Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Reduced pelvic pain
Most Useful Review
A must for those living in Finland. After a month of daily use, I’ve noticed a significant reduction in pelvic pain, and I now feel energised. While I'm unsure if this improvement is entirely due to the vitamin D, I highly recommend trying this specific product because its D3 is predominantly derived from fish oil rather than synthetic sources.
Anxiety
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.4
USERS' SCORE
Good
Based on 1 Review
8.5
8
High-dose vitamin D reduces anxiety
Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial.
Most Relevant Research
We conducted a study to understand how high-dose vitamin D supplementation might impact anxiety levels, particularly in patients experiencing post-COVID symptoms. In our double-blind, randomized controlled trial, we enrolled 80 individuals dealing with fatigue or neuropsychiatric issues after COVID-19.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
8.8
Mood improvement
Most Useful Review
I initially took this for fertility due to low vitamin D levels. However, the improvement in my moods and clinical depression has been significant. I battle social anxiety and have noticed a difference socially. The capsules are tiny and easy to swallow. This will be a permanent part of my supplement regimen.
Autoimmune Disorder
SCIENTIFIC SCORE
Possibly Effective
Based on 54 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Cod liver oil aids rheumatoid arthritis
Effect of cod liver oil on symptoms of rheumatoid arthritis.
Most Relevant Research
In a recent study involving 43 patients suffering from rheumatoid arthritis, we explored the impact of taking 1 gram of cod liver oil daily for three months. The results were striking. We observed notable reductions in morning stiffness by an impressive 52.4%, alongside decreases in both painful and swollen joints, each showing a 40% improvement. Pain intensity also saw a significant drop of 67.5%.
Additionally, the feedback from the patients was overwhelmingly positive. Approximately 68% reported that the treatment was effective, while a remarkable 95% praised its tolerability. However, it’s worth noting that 11 patients did experience some nonsevere adverse effects, but only three of those were possibly related to the cod liver oil itself.
Overall, it seems that cod liver oil can indeed offer relief for those grappling with rheumatoid arthritis, making it a treatment worth considering for improving symptoms of this autoimmune disorder.
Additionally, the feedback from the patients was overwhelmingly positive. Approximately 68% reported that the treatment was effective, while a remarkable 95% praised its tolerability. However, it’s worth noting that 11 patients did experience some nonsevere adverse effects, but only three of those were possibly related to the cod liver oil itself.
Overall, it seems that cod liver oil can indeed offer relief for those grappling with rheumatoid arthritis, making it a treatment worth considering for improving symptoms of this autoimmune disorder.
10
Improved health
Most Useful Review
Excellent. My wife, diagnosed with liver cancer, has experienced significant improvements since we began using products from iherb.com, recommended by our doctor Antti Heikkilä. She feels stronger, can walk a bit, and has regained hope for more years. Initially, an oncologist gave her two months to live in November 2010 due to her severe condition. Thanks to Dr Heikkilä’s advice, she now believes there might be a chance for more time. Thank you, iherb.com and Antti Heikkilä, for your assistance!
