Citracal Petites 400 mg Calcium Citrate

We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.

By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.

Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.

9.5

Improved bone density

Most Useful Review

Several years ago, my mother was diagnosed with osteoporosis and none of our previous medications worked. After a long search, I found this Calcium Supplement on iHerb, which truly works. Since she began taking it, her bone density indicators have started to improve, which had not been the case for years. While improvement doesn’t happen overnight, we noticed a significant change after six months, which is fantastic! The supply lasts a long time and she also takes vitamin D.

Leg Cramps

SCIENTIFIC SCORE

Questionable

Based on 10 Researches

Calcium dobesilate reduces leg cramps

Calcium dobesilate for chronic venous insufficiency: a systematic review.

Most Relevant Research

We examined the benefits of calcium dobesilate for patients suffering from chronic venous insufficiency (CVI), particularly focusing on how it impacts symptoms like leg cramps. In a systematic evaluation of ten different clinical trials involving 778 patients, we compared the effects of calcium dobesilate to a placebo.

Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.

Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.

Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.

9.5

Improved cramps

Most Useful Review

Good quality with high calcium content, suitable for all ages. It has helped significantly with leg cramps, contributing to bone development.

Cough

The new petite tablets are indeed easier to swallow. While the previous version was smaller, they were much harder to take. I struggled with them for years, often coughing them back up, and once they lodged in my throat, nearly obstructing my breathing. However, these new tablets go down very easily, and that’s what truly matters to me.

Insomnia

SCIENTIFIC SCORE

Possibly Effective

Based on 3 Researches

Vitamin D benefits for insomnia

Efficacy of low-fat milk and yogurt fortified with encapsulated vitamin D on improvement in symptoms of insomnia and quality of life: Evidence from the SUVINA trial.

Most Relevant Research

We set out to explore the relationship between vitamin D and insomnia by examining how low-fat milk and yogurt fortified with 1,500 IU of nano-encapsulated vitamin D could improve sleep issues and overall quality of life.

In our analysis, we included adults with abdominal obesity and a history of insomnia, identifying twenty-nine participants through insomnia severity questionnaires. They were split into four groups: one receiving fortified low-fat milk, another with unfortified milk, a third group consuming fortified yogurt, and a fourth with unfortified yogurt. Over a ten-week period, we tracked changes in insomnia symptoms and quality of life.

Our findings revealed that those drinking the vitamin D fortified milk experienced significant improvements in insomnia scores compared to those consuming regular milk. Additionally, quality of life assessments showed positive changes for both fortified and unfortified milk groups. However, the yogurt groups did not demonstrate significant benefits, indicating that while fortified dairy has potential, yogurt may not be as effective in this context.

In conclusion, incorporating fortified low-fat milk into our diets could help ease insomnia symptoms and enhance life satisfaction, although yogurt did not show the same promise.

2.5

Caused serious insomnia

Most Useful Review

This supplement seemed to cause serious insomnia. After starting it post-diagnosis of osteopenia, I experienced insomnia nightly, being awake until 5 am, which was unusual for me. After stopping Citrical, my insomnia vanished, leading me to believe this product is linked to my insomnia issues.

Osteoporosis

SCIENTIFIC SCORE

Possibly Effective

Based on 16 Researches

Vitamin D's impact on osteoporosis

The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis.

Most Relevant Research

We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.

The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.

Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.

This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.

8.8

Easily absorbed

Most Useful Review

I trust Citrical for my osteoporosis management as I have been taking calcium supplements daily since my diagnosis two years ago. It absorbs easily, and I appreciate that I can take it with or without food. Although I expected the petites to be smaller, they assist well with swallowing.