Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
The product is found useful for the following medical conditions
Allergies details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 6 Reviews
8.9
8
We investigated the potential of cyanocobalamin, or Vitamin B12, as a treatment for skin inflammation using a cutting-edge transdermal delivery system. The research focused on microneedle patches that effectively deliver this antioxidant form of Vitamin B12 into the skin.
Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.
However, it's important to note that while the results are promising, further studies are needed for broader applications.
Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.
However, it's important to note that while the results are promising, further studies are needed for broader applications.
9
Depression alleviated
Most Useful Review
4 people found this helpful
After using it for over a month, it proved effective, and my symptoms of vitamin B12 deficiency largely dissipated, particularly the depression caused by this deficiency. It caused no allergies or complications. It is safe and reasonably priced for me.
Nausea details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Good
Based on 10 Reviews
8.8
9
We observed how vitamin B12 deficiency can masquerade as serious conditions like hematologic malignancies, causing symptoms such as dizziness, nausea, and leukopenia. In our evaluation of a 39-year-old male, we found that treating severe B12 deficiency led to significant improvement in his blood counts.
After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.
After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.
9
Nausea alleviated
Most Useful Review
7 people found this helpful
I take 1 capsule each morning and evening for carpal tunnel syndrome. It used to be numb when I woke up, and I often felt numb during the day. Nausea was alleviated after about two weeks of taking it. I am mindful of light stretching and would like to continue taking more.
Vertigo details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
USERS' SCORE
Good
Based on 3 Reviews
8.7
9
Vitamin B12 enhances acupuncture effects
We explored the effectiveness of various treatments for cervical vertigo, specifically focusing on different acupuncture methods and the inclusion of Vitamin B12 in one of the therapy combinations. In our study, ninety-one participants were divided into three groups: one receiving routine acupuncture, another using electroacupuncture, and a third receiving a combination of electroacupuncture and Vitamin B12 injections along with local anesthetics.
Each therapy was administered over twenty sessions within a month. We measured changes in blood flow in the vertebral and basilar arteries and evaluated the participants' symptoms and overall function related to their vertigo. While all treatment methods showed some positive effects, the combination therapy, which included Vitamin B12, stood out as being the most effective.
This suggests that Vitamin B12 might play a significant role alongside acupuncture methods in treating cervical vertigo. However, it’s important to note that the specific impact of Vitamin B12 alone wasn’t isolated in this study, leaving us to consider its effects within the broader context of combined therapies.
Each therapy was administered over twenty sessions within a month. We measured changes in blood flow in the vertebral and basilar arteries and evaluated the participants' symptoms and overall function related to their vertigo. While all treatment methods showed some positive effects, the combination therapy, which included Vitamin B12, stood out as being the most effective.
This suggests that Vitamin B12 might play a significant role alongside acupuncture methods in treating cervical vertigo. However, it’s important to note that the specific impact of Vitamin B12 alone wasn’t isolated in this study, leaving us to consider its effects within the broader context of combined therapies.
10
Vertigo improvement
Most Useful Review
GOOD I was vitamin B12 deficient, and shortly after taking this, my vertigo disappeared within a week.
Cold Sores details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.5
9
Sore-free experience
Most Useful Review
I sought a B12 supplement that lacked xylitol and didn’t require dissolving under the tongue, as these caused sores in my mouth. This product contains the right ingredients and doesn’t induce sores, so I’m pleased.
Common Cold details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.5
9
Pain relief noted
Most Useful Review
37 people found this helpful
It worked well for my spinal pain due to cervical spondylosis myelopathy. After taking one vitamin B12 capsule daily, the pain in my neck and shoulders faded within a month, and the numbness in my fingers also improved. I'm now returning to my previous physical condition and plan to continue taking it.
Ulcer details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.8
USERS' SCORE
Good
Based on 10 Reviews
8.5
9
We delved into the complexities surrounding a specific genetic mutation in the LMBRD1 gene, which is linked to a variant form of cobalamin (vitamin B12) deficiency. This study highlighted a 15-year-old male with symptoms typical of Dyskeratosis Congenita, including skin hyperpigmentation and ulcers. After identifying a novel splice site deletion in the gene, we learned that this alteration can heavily impact vitamin B12 metabolism and lead to various clinical manifestations, including ulcers.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
10
Effective dosage
Most Useful Review
You must try Doctor's Best brand! The 1500mcg strength is effective, and I had 3 mouth ulcers. After taking 2 tiny pills, they vanished by morning! Fantastic!
Acne Rosacea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.4
9
Significant improvement
Most Useful Review
19 people found this helpful
Having suffered from severe inflammatory rosacea, I started taking a variety of vitamins, minerals, fatty acids, and superfoods from iHerb in April 2013. I read that B12 could be beneficial for rosacea, so I incorporated it into my regimen. Interestingly, several other bothersome issues seem to have improved since starting these supplements, leading me to suspect a B12 deficiency. I plan to consult my doctor about testing this. I’m awarding it 5 stars due to the significant improvement in my rosacea symptoms. It’s unclear whether one supplement or the combination is effective; however, I'm convinced that my regimen works better than the antibiotics prescribed by my dermatologist, which often come with side effects. After six months, should my results remain positive, I intend to share my supplement details on various Rosacea blogs to help fellow sufferers.
Cardiovascular Disease details
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.7
USERS' SCORE
Good
Based on 4 Reviews
8.4
8
We examined the role of vitamin B status on mortality rates, focusing on cardiovascular disease. Using data from over 12,000 adults, we found that higher scores on the combined vitamin B status indicator (3cB) were linked to lower risks of dying from cardiovascular issues. Specifically, individuals with lower 3cB scores faced significantly higher risks of mortality. This suggests that maintaining adequate vitamin B levels could potentially play an important part in reducing cardiovascular disease-related deaths.
9
Improved red blood cells
Most Useful Review
12 people found this helpful
This form of B12 genuinely works, as our lab results confirmed. While dealing with pernicious anaemia linked to blood cancer, I found traditional B12 ineffective. Once we began using this activated version, we observed a halt in the decline of hemoglobin levels, eventually seeing improvement. Regular use kept my red blood cell count above 8.5. It's vital for the formation of red blood cells, and many doctors underestimate its importance, despite the need for sufficient iron.
Celiac details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.4
9
Improved energy levels
Most Useful Review
2 people found this helpful
Excellent! This supplement has significantly assisted me with my B12 deficiency. Feeling run down for several months, I consulted a doctor, and the blood test confirmed my low B12 levels. After taking the supplement as directed, my energy, mood, and memory have improved markedly. I recently retested my B12 levels, and I am pleased to report an increase. I highly recommend it for those seeking a natural, vegan, and gluten-free way to boost B12.
Chest Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
USERS' SCORE
Good
Based on 7 Reviews
8.4
8
We observed an intriguing case involving a patient suffering from chest pain alongside severe anemia and vitamin B12 deficiency. The patient, a 44-year-old Hispanic woman, presented with escalating non-radiating chest pain, fatigue, and shortness of breath over three weeks. Her lab results showed critical pancytopenia and macrocytosis, raising concerns about a rare condition known as pseudo-thrombotic microangiopathy (TMA), which can occur due to vitamin B12 deficiency.
Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.
This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.
This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
9
Reduced pain
Most Useful Review
37 people found this helpful
It worked well for my spinal cord pain related to cervical spondylosis myelopathy. I started taking one capsule of vitamin B12 daily, and within a month, my neck and shoulder pain diminished significantly. The numbness in my fingers also subsided, and the cold sensation vanished. I'm now returning to my pre-illness physical condition, but I plan to continue taking it.
Frozen Shoulder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 19 Reviews
8.4
9
Reduced neck pain
Most Useful Review
37 people found this helpful
It worked well for my spinal cord pain associated with frozen shoulder. After taking one capsule of vitamin B12 daily, the discomfort in my neck and shoulder blades gradually faded. Within a month, the numbness in my fingers diminished, and the feeling of cold disappeared! I’m pleased to be returning to my previous physical condition and plan to continue taking it.
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.4
9
Legs feel better
Most Useful Review
2 people found this helpful
Amazing! The discomfort in my legs during sleep has vanished, bringing me peace and quiet. I hope this product is the reason for such improvement!
Liver Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.7
USERS' SCORE
Good
Based on 5 Reviews
8.4
9
We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
9
Improved blood count
Most Useful Review
12 people found this helpful
This form of B12 genuinely works, as confirmed by lab results. I struggled with liver disease and pernicious anaemia, leading to severe drops in haemoglobin. After changing to this methylated B12, my haemoglobin levels stabilised and even began to rise. This product, alongside iron supplements, has been crucial in managing my red blood cell count, which has remained above 8.5.
Neuropathy details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
USERS' SCORE
Good
Based on 23 Reviews
8.4
8
We explored the effects of vitamin B12 deficiency on neurological health in elderly patients. In a case study involving two patients, we observed that even with normal B12 levels, symptoms like fatigue and cognitive impairment persisted, especially in those with significant medical histories.
Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.
Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.
10
Miraculous cat recovery
Most Useful Review
7 people found this helpful
This worked wonders for my diabetic cat, whose neuropathy made him visibly pained in his feet. After reading about the Methyl form of B12, I tried it, and within two days, he went from hobbling to chasing toys. I give him one capsule twice a day mixed with food, and the price is excellent, especially with a subscription.
Rash details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.4
9
Rashes cleared quickly
Most Useful Review
1 people found this helpful
Despite having good skin and no acne during my teenage years, I began experiencing skin rashes and cracks around my nose, ears, and forehead as an adult. I tried various creams to no avail. After discovering that my B12 levels were extremely low, I decided to try this product. Within just 2 weeks of taking it, my skin condition improved remarkably. The reason remains a mystery, but I am relieved my skin is back to normal.
Shingles details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Good
Based on 4 Reviews
8.4
8
We conducted a review of randomized controlled trials to determine the effectiveness of vitamin B12 in treating postherpetic neuralgia (PHN), a painful condition following shingles. Our analysis included data from databases such as PubMed and Cochrane Library, focusing specifically on trials that measured pain relief outcomes.
Our findings indicate that vitamin B12 supplementation has a significant positive effect on reducing pain levels in PHN patients. In fact, those who received vitamin B12 experienced a notable decrease in pain compared to those on placebo, with a reduction in the pain score of about four points. This result suggests that vitamin B12 not only helps with pain relief but also enhances overall quality of life for individuals suffering from this distressing condition.
Additionally, we observed a drop in the number of patients relying on analgesics, pointing to a potential alternative treatment avenue with vitamin B12. Although the evidence is moderate in quality, it presents a compelling case for the use of vitamin B12 as a complementary therapy for managing pain associated with shingles.
Our findings indicate that vitamin B12 supplementation has a significant positive effect on reducing pain levels in PHN patients. In fact, those who received vitamin B12 experienced a notable decrease in pain compared to those on placebo, with a reduction in the pain score of about four points. This result suggests that vitamin B12 not only helps with pain relief but also enhances overall quality of life for individuals suffering from this distressing condition.
Additionally, we observed a drop in the number of patients relying on analgesics, pointing to a potential alternative treatment avenue with vitamin B12. Although the evidence is moderate in quality, it presents a compelling case for the use of vitamin B12 as a complementary therapy for managing pain associated with shingles.
9
Gradual pain relief
Most Useful Review
6 people found this helpful
After getting shingles, the prescribed medication from the hospital did not alleviate my pain. Knowing B12 was beneficial, I purchased this product. Initially sceptical about its low price and small capsules, I continued to take one each night. There was no immediate effect, but gradually, the pain eased and completely disappeared about two weeks later. Now, I take it twice a week.
Back Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.3
USERS' SCORE
Good
Based on 41 Reviews
8.3
9
We evaluated the effectiveness of intramuscular vitamin B12 in treating low back pain among 60 patients aged 18 to 65 with mechanical pain lasting at least six months.
In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.
Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.
In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.
Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.
9
Pain relief noted
Most Useful Review
37 people found this helpful
It worked well for my back pain linked to cervical spondylosis myelopathy. I started taking one capsule of vitamin B12 daily, and after a month, the pain in my neck and shoulders disappeared, along with the numbness in my fingers. I am now returning to my previous physical condition and will continue taking it.
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 53 Reviews
8.3
9
Gradual pain relief
Most Useful Review
37 people found this helpful
It worked well for pain in my spinal cord caused by cervical spondylosis myelopathy. When I struggled to sleep and felt like crying, I turned to vitamin B12 for nerve repair. After starting with one capsule daily, my pain gradually diminished. The discomfort in my neck and shoulder blades vanished within a month, and the lingering numbness in my fingers has ceased. I'm returning to my former physical condition and plan to continue taking it in the future.
Knee Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 13 Reviews
8.3
9
Knee pain relief
Most Useful Review
4 people found this helpful
I have suffered from knee pain due to sciatica for over six months. After starting this supplement, my symptoms significantly improved, including the knee pain I experienced. I feel happier and more positive now, thanks to this product.
Sciatica details
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Good
Based on 13 Reviews
8.3
5
We explored the effects of Vitamin B12 and alpha lipoic acid (ALA) on nerve recovery in a rat model of sciatic nerve injury.
Through a rigorous study design involving 40 rats divided into different treatment groups, we assessed functional recovery using various analyses.
Interestingly, while both treatments yielded positive results, ALA showed greater functional improvements compared to B12.
Overall, B12 was effective in enhancing myelination and reducing edema, highlighting its unique benefits alongside ALA’s advantages.
Through a rigorous study design involving 40 rats divided into different treatment groups, we assessed functional recovery using various analyses.
Interestingly, while both treatments yielded positive results, ALA showed greater functional improvements compared to B12.
Overall, B12 was effective in enhancing myelination and reducing edema, highlighting its unique benefits alongside ALA’s advantages.
10
Pain relief achieved
Most Useful Review
29 people found this helpful
It has been 7 months since I began taking vitamin B12 for my sciatica, which was initially so severe that I couldn't walk. After 4 months, the pain had almost disappeared, and now I feel no pain at all. I used to suffer from this hernia-related pain every day for nearly two years. I still take it daily after meals, as it’s a small capsule that's easy to swallow. I highly recommend it for anyone dealing with nerve pain!
Swollen Lymph Nodes details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.3
9
Numbness reduced
Most Useful Review
5 people found this helpful
Seven or eight months post-surgery on my left ankle, my foot remained swollen and numb. The rehabilitation doctor recommended B12 to help alleviate the numbness. After a period of taking it, I noticed a significant improvement in the numbness in my feet.
Carpal Tunnel Syndrome details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.1
USERS' SCORE
Good
Based on 9 Reviews
8.2
9
We conducted a study to investigate the effects of mecobalamin, a form of vitamin B12, on carpal tunnel syndrome (CTS) in stroke patients. Our research involved a group of 135 stroke patients, with 67 receiving 1,500 micrograms of mecobalamin daily for two years, while the other 68 patients did not receive any treatment.
Remarkably, we found that many stroke patients exhibited greater abnormality in the nerve function of their nonparetic side (the side of the body not affected by stroke) compared to the hemiparetic side (the affected side). Before treatment began, nearly a third of both groups met the criteria for CTS.
Over the two years, those who took mecobalamin showed a significant improvement in sensory nerve responses when compared to the untreated group. We observed that even though both sensory and motor nerve functions improved, the sensory nerve functions in the treated patients improved more noticeably. Importantly, there were no reported side effects from the treatment, suggesting that oral mecobalamin could be a safe and beneficial option for managing CTS, especially in stroke patients.
Remarkably, we found that many stroke patients exhibited greater abnormality in the nerve function of their nonparetic side (the side of the body not affected by stroke) compared to the hemiparetic side (the affected side). Before treatment began, nearly a third of both groups met the criteria for CTS.
Over the two years, those who took mecobalamin showed a significant improvement in sensory nerve responses when compared to the untreated group. We observed that even though both sensory and motor nerve functions improved, the sensory nerve functions in the treated patients improved more noticeably. Importantly, there were no reported side effects from the treatment, suggesting that oral mecobalamin could be a safe and beneficial option for managing CTS, especially in stroke patients.
9
Numbness alleviated
Most Useful Review
10 people found this helpful
I highly recommend it! After experiencing numbness at the base of my thumb, I discovered it was Carpal Tunnel Syndrome. Methylcobalamin was prescribed, and after researching, I found that vitamin B12 was the primary component. I took one capsule with dinner, along with a support band, and the numbness faded after three consecutive days. Although I still feel a little uncomfortable, it is improving daily, and I will continue taking it.
Cold details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Good
Based on 18 Reviews
8.2
8
We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
9
Pain relief achieved
Most Useful Review
37 people found this helpful
It worked well for pain in my spinal cord due to cervical spondylosis myelopathy. When I was having trouble sleeping and feeling emotional, I turned to vitamin B12 for nerve repair. After taking one capsule daily, the pain in my neck and shoulder blades eased within a month, and the numbness in my fingers vanished. Most notably, the feeling of cold also disappeared! I’m gradually returning to my pre-illness condition, and I plan to continue this treatment.
Diabetes details
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.9
USERS' SCORE
Good
Based on 23 Reviews
8.2
8
We explored a novel oral delivery system using vitamin B12, fucoidan, and concanavalin A to enhance insulin effectiveness for diabetes management. This smart nanosystem targets inflammation while regulating blood glucose levels efficiently. Our findings indicated that when tested on type I diabetic mice, the nanosystem significantly lowered blood sugar and reduced inflammatory markers, such as TNF-α and interleukin-6. Notably, the system ensures safe and effective delivery, presenting a promising alternative to traditional insulin methods.
9
Pain relief experienced
Most Useful Review
7 people found this helpful
I was struggling with severe back pain and could barely stand, but after taking one capsule post-breakfast, the pain diminished significantly within three days. This unexpected relief makes me extremely grateful. I suspect that, along with my diabetes medication, the B12 supplement has contributed to my recovery.
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.4
USERS' SCORE
Good
Based on 21 Reviews
8.2
9.5
We examined a unique case involving a 28-year-old male who experienced dizziness related to severe anemia from low vitamin B12 levels.
After treatment with daily vitamin B12 injections, his symptoms and lab values significantly improved, indicating a positive response to the treatment.
Despite the rare nature of his condition—seronegative pernicious anemia—the results suggest that B12 can effectively alleviate dizziness stemming from anemia in similar cases.
After treatment with daily vitamin B12 injections, his symptoms and lab values significantly improved, indicating a positive response to the treatment.
Despite the rare nature of his condition—seronegative pernicious anemia—the results suggest that B12 can effectively alleviate dizziness stemming from anemia in similar cases.
8
High-quality supplement
Most Useful Review
17 people found this helpful
Vitamin B12 addresses issues related to the semicircular canals and the optic nerve. In Japan, esteemed otolaryngologists recommend it for primary hearing loss and dizziness. This particular B12, featuring methylcobalamin, is high-quality and easy to swallow due to its small capsule size. Its price is reasonable, making it a staple supplement, akin to vitamin C. While chewables exist, I suggest the capsule form for adults to avoid moisture.
Ear Infection details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 13 Reviews
8.2
9
Improved hearing
Most Useful Review
8 people found this helpful
I experienced muffled hearing in one ear, and after consulting a doctor, I was prescribed various medications, including B12. Research indicated that B12 could benefit my hearing, so I continued taking it. I'm pleased with how inexpensively I could purchase it from iHerb. Since starting this supplement, my ear problems have improved and haven't recurred. Early treatment for hearing issues is crucial; see a doctor if anything feels off.
Heart Disease details
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.2
USERS' SCORE
Good
Based on 6 Reviews
8.2
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
8
Pain relief
Most Useful Review
8 people found this helpful
B12 is of excellent quality with quick delivery to the postamat. The capsules are convenient for oral intake. After experiencing incessant back pains around my heart post-coronavirus, I took this on my doctor's recommendation. The taste is pleasant, with high purity ingredients. I've noticed my back pain has ceased, and my energy levels have surged within a week of use. It contains 1,500 mcg of B12.
Migraine details
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.2
USERS' SCORE
Good
Based on 10 Reviews
8.2
7
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
10
Stops migraines effectively
Most Useful Review
Excellent! This great vitamin works perfectly; after taking it, my migraines have stopped.
Blurred Vision details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.1
9
Clearer vision
Most Useful Review
3 people found this helpful
I can see clearly from my previously blurry eyes. The effect is remarkable. My vision used to be blurred from excessive eye use, but it's improved significantly since taking this supplement. I have purchased it multiple times, and its ingredients truly work, so I recommend it.
Depression details
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.9
USERS' SCORE
Good
Based on 24 Reviews
8.1
8
We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
9
Reduced depressive symptoms
Most Useful Review
4 people found this helpful
After a month, my symptoms of vitamin B12 deficiency, including depression, significantly decreased. I experienced no allergies or complications. It is safe for me and reasonably priced.
Hair Loss details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 30 Reviews
8.1
9
Stopped hair loss
Most Useful Review
Excellent vitamins; the course truly addressed my hair loss issue, as my hair stopped falling out and my overall health improved.
Heart Attack details
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
3
USERS' SCORE
Good
Based on 8 Reviews
8.1
4
Vitamin B12 shows no heart attack benefit
In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
9
Seizure stability
Most Useful Review
6 people found this helpful
After surviving a heart attack in September 2019, I faced a recurrence shortly after. Following the recommendation of a book by Dr. Mitsuishi and Dr. Fujikawa, I began taking this supplement. Since then, I haven’t experienced any further seizures, and my wife's “trigger finger” has improved. I'm unsure which supplement is responsible as I was using several, but I appreciate the benefits we’ve noticed.
Mild Cognitive Impairment details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 26 Reviews
8.1
9
Effective for neurological health
Most Useful Review
11 people found this helpful
Methylcobalamin, unlike cyanocobalamin, is a natural and better-absorbed form of vitamin B12. It aids in neuronal lipid production, nerve regeneration, and has neuroprotective properties, which are beneficial for conditions like Alzheimer's disease and dementia. A starting dose of 1500mcg is generally non-toxic and effectively used, as only the needed amount is absorbed. It's important to let the capsule dissolve in your mouth. The product is reasonably priced.
Autism details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 4 Reviews
8
4
We conducted a study that examined the levels of vitamin B12, homocysteine, and anti-parietal cell antibodies in children diagnosed with autism spectrum disorder (ASD) compared to a control group. Our research included 69 children, where 36 had ASD, and 33 were matched controls based on age, sex, and socioeconomic status. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS), while serum levels were measured using a common laboratory technique called enzyme-linked immunosorbent assay.
Our findings revealed that children with ASD had significantly lower levels of vitamin B12 and homocysteine compared to their peers in the control group. However, we found no significant difference in the levels of anti-parietal cell antibodies, which suggests that vitamin B12 deficiency may not be due to absorption issues related to these antibodies. While we observed notable micronutrient deficiencies, it’s important to clarify that the study did not establish a direct benefit of vitamin B12 treatment for autism symptoms.
Importantly, this research hints at the potential role that vitamin B12 deficiencies may play in the clinical features of autism. Nonetheless, we believe that further studies involving larger populations are necessary to better understand how these micronutrient levels might influence the condition and its underlying causes.
Our findings revealed that children with ASD had significantly lower levels of vitamin B12 and homocysteine compared to their peers in the control group. However, we found no significant difference in the levels of anti-parietal cell antibodies, which suggests that vitamin B12 deficiency may not be due to absorption issues related to these antibodies. While we observed notable micronutrient deficiencies, it’s important to clarify that the study did not establish a direct benefit of vitamin B12 treatment for autism symptoms.
Importantly, this research hints at the potential role that vitamin B12 deficiencies may play in the clinical features of autism. Nonetheless, we believe that further studies involving larger populations are necessary to better understand how these micronutrient levels might influence the condition and its underlying causes.
9
Behavioral improvements
Most Useful Review
Excellent! My daughter, who has autism, has shown significant improvement in her behavioural issues. The dosage is effective, and I am pleased with the quality of the product, which I also take myself.
Flu details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 14 Reviews
8
9
Boosts for flu
Most Useful Review
Excellent product for increasing B12 levels, especially for those with folate cycle mutations. I take it on an empty stomach and feel an increase in energy as well as a good effect on my nervous system. I highly recommend it and plan to order more.
Osteoporosis details
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
5.8
USERS' SCORE
Good
Based on 5 Reviews
8
7
We explored how vitamin B12 affects spinal fractures in patients with osteoporosis, a condition that significantly increases the risk of these injuries. Our investigation involved 105 participants diagnosed with osteoporosis. We assessed clinical data alongside blood levels of several vitamins, including vitamin B12, to understand their connection to spinal fractures.
Our analysis revealed a substantial relationship between elevated vitamin B12 levels and the incidence of spinal fractures. We found that not only was there a notable association with spinal fractures, but higher vitamin B12 was also linked to a shorter time before a recurrence of fractures occurred. These findings suggest that as vitamin B12 levels rise, the risk for spinal fractures in osteoporosis patients increases, which indicates a potentially serious concern for these individuals.
While vitamin B9 also showed some association, it was vitamin B12 that stood out in both our logistic regression analyses. Overall, our results suggest that monitoring and perhaps addressing vitamin B12 levels could be crucial for managing patients’ health and preventing further complications from osteoporosis.
Our analysis revealed a substantial relationship between elevated vitamin B12 levels and the incidence of spinal fractures. We found that not only was there a notable association with spinal fractures, but higher vitamin B12 was also linked to a shorter time before a recurrence of fractures occurred. These findings suggest that as vitamin B12 levels rise, the risk for spinal fractures in osteoporosis patients increases, which indicates a potentially serious concern for these individuals.
While vitamin B9 also showed some association, it was vitamin B12 that stood out in both our logistic regression analyses. Overall, our results suggest that monitoring and perhaps addressing vitamin B12 levels could be crucial for managing patients’ health and preventing further complications from osteoporosis.
9
Supports general health
Most Useful Review
This product is extremely useful. It greatly benefits the body, nerves, and overall health. I use it alongside my family as it’s one of the most important vitamins for daily health. It promotes bone growth and helps prevent osteoporosis. Nutritionists emphasise the significance of vitamin B12 and its role in supporting mood and mental health.
Stroke details
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
USERS' SCORE
Good
Based on 5 Reviews
8
8
We explored the role of vitamin B12 in managing neuroinflammation after an ischemic stroke. Through preclinical studies, we observed that vitamin B12 effectively influenced microglial cells, which are key to the brain's immune response. This treatment promoted important cellular processes, leading to reduced brain damage and better neurological outcomes. However, when microglia were depleted before stroke, the positive effects of vitamin B12 disappeared. Overall, while vitamin B12 shows promise in enhancing recovery post-stroke, its impact hinges on these immune cells.
9
Aids stroke rehabilitation
Most Useful Review
Vitamin B12 is an excellent aid for nervous system disorders. This nutrient has a high concentration and is beneficial for serious nervous system issues. Research shows it significantly helps in stroke rehabilitation. It is essential to follow the packaging instructions and to consult with a neurologist before beginning supplementation, which I did.
Weight Loss details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8
9
Assisted weight loss
Most Useful Review
3 people found this helpful
I've been taking these B12 supplements alongside Metabolic Advantage and am pleased to report that I've felt they assist my weight loss efforts. I will continue to use them.
Alzheimer details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.9
4
We explored the potential role of vitamin B12, alongside folic acid, in slowing the progression of Alzheimer's disease (AD) through a meta-analysis of randomized control trials. Our aim was to determine whether these supplements might improve cognitive function, daily life activities, and influence blood homocysteine levels in individuals diagnosed with AD.
After carefully sifting through studies, we found five that met our criteria. These studies assessed the cognitive changes in participants through the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Additionally, they examined the impact on daily functioning as well as blood homocysteine levels.
The results showed that after six months of treatment, participants taking vitamin B12 and folic acid did experience a slight improvement in MMSE scores compared to those on a placebo. However, there was no significant change in the ADAS-Cog scores, which means some cognitive aspects didn’t show marked improvement. Likewise, daily life functioning did not see any benefits from the supplements.
Importantly, we also noted a significant reduction in blood homocysteine levels following the supplementation, suggesting a biochemical effect of the treatment. Overall, while vitamin B12 shows promise in enhancing some cognitive measures, it does not translate directly into broader cognitive or daily functioning improvements in Alzheimer's patients.
After carefully sifting through studies, we found five that met our criteria. These studies assessed the cognitive changes in participants through the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Additionally, they examined the impact on daily functioning as well as blood homocysteine levels.
The results showed that after six months of treatment, participants taking vitamin B12 and folic acid did experience a slight improvement in MMSE scores compared to those on a placebo. However, there was no significant change in the ADAS-Cog scores, which means some cognitive aspects didn’t show marked improvement. Likewise, daily life functioning did not see any benefits from the supplements.
Importantly, we also noted a significant reduction in blood homocysteine levels following the supplementation, suggesting a biochemical effect of the treatment. Overall, while vitamin B12 shows promise in enhancing some cognitive measures, it does not translate directly into broader cognitive or daily functioning improvements in Alzheimer's patients.
9
Enhanced nerve function
Most Useful Review
11 people found this helpful
Unlike cyanocobalamin, methylcobalamin is a naturally occurring form of vitamin B12, better absorbed in our tissues. It aids in neuronal lipid production and promotes nerve regeneration, offering neuroprotective benefits essential for conditions like Alzheimer’s and Parkinson’s disease. A dosage of 1500mcg is safe and effective, as your body absorbs what it needs and excretes excess. It's crucial not to swallow the capsule but to let it dissolve in your mouth. The cost is reasonable too.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.6
USERS' SCORE
Moderately Good
Based on 32 Reviews
7.9
9
We examined a case of a 51-year-old Ugandan man who experienced recurring lower limb weakness linked to pernicious anemia, an autoimmune condition causing vitamin B12 deficiency. After initial treatments, his symptoms reappeared, leading to further testing that confirmed the diagnosis.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
9
Muscle relaxation benefits
Most Useful Review
21 people found this helpful
For nerve and muscle relaxation, this easily digestible form works excellently. I have been drinking it for over a year, experiencing reduced body aches and irritability. B12 helps relax muscle fibres, relieving tensions. My nails improved too; white spots indicated a lack of B12. I would have avoided many issues had I started this sooner; it truly impacts the nervous system positively.
Sleep Apnea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.9
9
Reduced insomnia
Most Useful Review
2 people found this helpful
Fabulous! I no longer experience restless legs at night and enjoy a peaceful sleep. Perhaps this product is the reason? I hope so!
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
USERS' SCORE
Moderately Good
Based on 26 Reviews
7.8
9
We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
7.5
Dizziness improved
Most Useful Review
15 people found this helpful
It's working! I bought this because my father had a cerebral infarction which affected his blood circulation and made him feel lightheaded. I wasn't expecting much, but my father, who used to suffer from dizziness, has reported significant improvement and appears to be sleeping better. I've sent it a few times and it seems to be effective.
Insomnia details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.7
USERS' SCORE
Moderately Good
Based on 15 Reviews
7.8
8
Vitamin B12 promotes sleep in rats
We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
7.5
Good for bedtime
Most Useful Review
2 people found this helpful
It truly helps with my insomnia. I take one or two before bed, acting like a gentle sleeping pill. Even a high dose of 3000 mcg does not adversely affect me.
Anemia details
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.2
USERS' SCORE
Moderately Good
Based on 58 Reviews
7.7
9.5
We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
9
Effective for anemia
Most Useful Review
12 people found this helpful
I found this form of B12 to be effective. After dealing with blood cancer-related pernicious anaemia and declining haemoglobin levels, I researched B12 and discovered the activated version. Within a week of using this, my haemoglobin levels stabilised and eventually improved. While it's not the sole treatment needed for red blood cells, it is vital. Many doctors seem unaware of the importance of activated B12 for red blood cell formation.
Anxiety details
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.4
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.7
8
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
9
Anxiety improvements
Most Useful Review
9 people found this helpful
This is my repeat order. It is highly absorbable with no chemical ingredients. I've been taking it for my chronic anxiety and depression, and after three months, my neurological symptoms have greatly improved.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Moderately Good
Based on 67 Reviews
7.7
0
Vitamin B12 ineffective for CFS
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
9
Nervous system health
Most Useful Review
41 people found this helpful
This is a vital vitamin for my brain and nervous system function! It’s hard to get enough from food, so supplementation is crucial for combating chronic fatigue syndrome, stress, and insomnia. I take it with folic acid, as they work well together.
Tinnitus details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
5.4
USERS' SCORE
Moderately Good
Based on 22 Reviews
7.7
1
We conducted a double-blind clinical trial with 140 patients suffering from idiopathic tinnitus to gauge the effectiveness of vitamin B12. Participants were divided into two groups, one receiving vitamin B12 and the other a placebo over a month.
We evaluated tinnitus severity through questionnaires at multiple intervals. However, our findings revealed that vitamin B12 did not significantly reduce tinnitus severity compared to the placebo.
Ultimately, our study suggests that vitamin B12 may not be a beneficial treatment for tinnitus, as the results showed no noteworthy improvements.
We evaluated tinnitus severity through questionnaires at multiple intervals. However, our findings revealed that vitamin B12 did not significantly reduce tinnitus severity compared to the placebo.
Ultimately, our study suggests that vitamin B12 may not be a beneficial treatment for tinnitus, as the results showed no noteworthy improvements.
7.5
Reduced tinnitus
Most Useful Review
10 people found this helpful
I took this for my tinnitus, and when combined with zinc, the high-pitched noise in my ears diminished significantly. The quality of the ingredients appears adequate, and the small capsules are easy to swallow, with no taste or odour. It is effective for early tinnitus and seems beneficial for the nervous system. Although it contains 180 tablets, I suggest repackaging them in a smaller bottle.
Blood Clot details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.9
USERS' SCORE
Moderately Good
Based on 21 Reviews
7.6
8
We examined a case involving a 56-year-old male who suffered from severe vitamin B12 deficiency. This deficiency led to dangerously high homocysteine levels, which are associated with blood clot formation. Despite effective treatment with B12, this case illustrates that vitamin deficiency can lead to significant health issues, including thrombosis and embolism.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
9
Reduced fatigue
Most Useful Review
1 people found this helpful
I cannot take iron supplements due to severe anaemia, so my doctor advised B12 and folic acid instead. B12 aids in red blood cell production, and since taking this product for over a month, it has alleviated my dizziness and fatigue. The capsules are easy to swallow, and the large package lasts half a year, saving hassle.
Constipation details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 11 Reviews
7.5
9
Does not cause constipation
Most Useful Review
I highly recommend this excellent product. It is of good quality, suitable for adults, and beneficial. The taste is pleasant, and it contains organic ingredients that do not cause intestinal constipation.
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.3
USERS' SCORE
Moderately Good
Based on 24 Reviews
7.3
8
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
9
Effective headache relief
Most Useful Review
3 people found this helpful
Eating this every day prevents headaches. If I forget, I experience pain, so it truly is effective.
