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Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
The product is found useful for the following medical conditions
Back Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Good
Based on 41 Reviews
8.9
9
Vitamin B12 aids low back pain
Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.
Most Relevant Research
We conducted a thorough investigation to understand whether intramuscular vitamin B12 treatment could effectively relieve low back pain. This study was designed as a double-blind, placebo-controlled trial involving 60 patients aged 18 to 65 who suffered from mechanical low back pain or sciatic neuritis. Each participant had a history of back pain lasting from six months to five years and reported significant pain intensity according to a standard scale.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
9.5
Pain relief noted
Most Useful Review
It worked well for my back pain linked to cervical spondylosis myelopathy. I started taking one capsule of vitamin B12 daily, and after a month, the pain in my neck and shoulders disappeared, along with the numbness in my fingers. I am now returning to my previous physical condition and will continue taking it.
Common Cold
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.8
9.5
Pain relief noted
Most Useful Review
It worked well for my spinal pain due to cervical spondylosis myelopathy. After taking one vitamin B12 capsule daily, the pain in my neck and shoulders faded within a month, and the numbness in my fingers also improved. I'm now returning to my previous physical condition and plan to continue taking it.
Frozen Shoulder
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 19 Reviews
8.8
9.5
Reduced neck pain
Most Useful Review
It worked well for my spinal cord pain associated with frozen shoulder. After taking one capsule of vitamin B12 daily, the discomfort in my neck and shoulder blades gradually faded. Within a month, the numbness in my fingers diminished, and the feeling of cold disappeared! I’m pleased to be returning to my previous physical condition and plan to continue taking it.
Knee Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 13 Reviews
8.8
9.5
Knee pain relief
Most Useful Review
I have suffered from knee pain due to sciatica for over six months. After starting this supplement, my symptoms significantly improved, including the knee pain I experienced. I feel happier and more positive now, thanks to this product.
Neuropathy
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.2
USERS' SCORE
Good
Based on 5 Reviews
8.8
9
Nitrous oxide affects B12 levels
Correlation Between Nitrous Oxide and Functional Vitamin B12 Deficiency Resulting in Subacute Combined Degeneration of the Spinal Cord: A Case Report.
Most Relevant Research
We examined a remarkable case involving the effects of nitrous oxide (NO) on vitamin B12 levels and its neurological consequences. Nitrous oxide is not just a useful tool in medical and food industries; it is sometimes misused by young adults for recreational purposes. This misuse can lead to functional vitamin B12 deficiency, which in turn may result in serious neurological issues like peripheral neuropathy and subacute combined degeneration (SACD) of the spinal cord.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
10
Miraculous cat recovery
Most Useful Review
This worked wonders for my diabetic cat, whose neuropathy made him visibly pained in his feet. After reading about the Methyl form of B12, I tried it, and within two days, he went from hobbling to chasing toys. I give him one capsule twice a day mixed with food, and the price is excellent, especially with a subscription.
Chest Pain
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
USERS' SCORE
Good
Based on 7 Reviews
8.7
8
Vitamin B12 improves chest pain
Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency.
Most Relevant Research
We observed an intriguing case involving a patient suffering from chest pain alongside severe anemia and vitamin B12 deficiency. The patient, a 44-year-old Hispanic woman, presented with escalating non-radiating chest pain, fatigue, and shortness of breath over three weeks. Her lab results showed critical pancytopenia and macrocytosis, raising concerns about a rare condition known as pseudo-thrombotic microangiopathy (TMA), which can occur due to vitamin B12 deficiency.
Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.
This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.
This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
9.5
Reduced pain
Most Useful Review
It worked well for my spinal cord pain related to cervical spondylosis myelopathy. I started taking one capsule of vitamin B12 daily, and within a month, my neck and shoulder pain diminished significantly. The numbness in my fingers also subsided, and the cold sensation vanished. I'm now returning to my pre-illness physical condition, but I plan to continue taking it.
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 67 Reviews
8.7
0
Vitamin B12 ineffective for CFS
N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.
Most Relevant Research
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
9.5
Nervous system health
Most Useful Review
This is a vital vitamin for my brain and nervous system function! It’s hard to get enough from food, so supplementation is crucial for combating chronic fatigue syndrome, stress, and insomnia. I take it with folic acid, as they work well together.
Cold Sores
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.7
9.5
Sore-free experience
Most Useful Review
I sought a B12 supplement that lacked xylitol and didn’t require dissolving under the tongue, as these caused sores in my mouth. This product contains the right ingredients and doesn’t induce sores, so I’m pleased.
Depression
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
USERS' SCORE
Good
Based on 24 Reviews
8.7
2
Vitamin B12 shows no benefit for depression
Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis.
Most Relevant Research
We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
9.5
Reduced depressive symptoms
Most Useful Review
After a month, my symptoms of vitamin B12 deficiency, including depression, significantly decreased. I experienced no allergies or complications. It is safe for me and reasonably priced.
Diabetes
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
USERS' SCORE
Good
Based on 23 Reviews
8.7
9
Vitamin B12 improves eye movements
The Effectiveness of Steroid Versus Vitamin Therapy in the Improvement of Extraocular Movements in Patients With Diabetic Cranial Nerve Palsy: A Comparative Study.
Most Relevant Research
We explored the effectiveness of vitamin B12 in treating diabetic ocular nerve palsy, a complication that can occur in people with diabetes. In a recent study, fifty individuals with this condition were divided into two groups. One group received steroid treatments while the other was treated with vitamin B12 injections.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
9.5
Pain relief experienced
Most Useful Review
I was struggling with severe back pain and could barely stand, but after taking one capsule post-breakfast, the pain diminished significantly within three days. This unexpected relief makes me extremely grateful. I suspect that, along with my diabetes medication, the B12 supplement has contributed to my recovery.
Dizziness
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.1
USERS' SCORE
Good
Based on 21 Reviews
8.7
9
Vitamin B12 improves dizziness symptoms
Acute presentation of dizziness in vitamin B12 deficient old patient of cardiac disease: a case report.
Most Relevant Research
We observed a fascinating case involving an elderly patient who experienced acute dizziness, ataxia, and imbalance shortly after receiving a pacemaker. Upon investigation, we discovered that her symptoms were linked to a significant deficiency in vitamin B12.
The patient's vitamin B12 levels were notably low, accompanied by increased plasma homocysteine and methylmalonic acid levels. Despite her neurological symptoms suggesting peripheral neuropathy, her brain scan returned normal results. What stood out to us was the absence of the typical hematological signs often associated with vitamin B12 deficiency.
Importantly, the patient responded remarkably well to treatment with parenteral vitamin B12, leading to a resolution of her dizziness. This case underscores the importance of considering vitamin B12 deficiency, especially in elderly patients who present with neuropsychiatric symptoms. As we reflected on this, it became clear that proper recognition and treatment of vitamin B12 deficiency can significantly influence patient outcomes.
The patient's vitamin B12 levels were notably low, accompanied by increased plasma homocysteine and methylmalonic acid levels. Despite her neurological symptoms suggesting peripheral neuropathy, her brain scan returned normal results. What stood out to us was the absence of the typical hematological signs often associated with vitamin B12 deficiency.
Importantly, the patient responded remarkably well to treatment with parenteral vitamin B12, leading to a resolution of her dizziness. This case underscores the importance of considering vitamin B12 deficiency, especially in elderly patients who present with neuropsychiatric symptoms. As we reflected on this, it became clear that proper recognition and treatment of vitamin B12 deficiency can significantly influence patient outcomes.
9
High-quality supplement
Most Useful Review
Vitamin B12 addresses issues related to the semicircular canals and the optic nerve. In Japan, esteemed otolaryngologists recommend it for primary hearing loss and dizziness. This particular B12, featuring methylcobalamin, is high-quality and easy to swallow due to its small capsule size. Its price is reasonable, making it a staple supplement, akin to vitamin C. While chewables exist, I suggest the capsule form for adults to avoid moisture.
Vertigo
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
USERS' SCORE
Good
Based on 3 Reviews
8.7
9
Vitamin B12 enhances acupuncture effects
[Observation of therapeutic effects on cervical vertigo treated with different methods].
Most Relevant Research
We explored the effectiveness of various treatments for cervical vertigo, specifically focusing on different acupuncture methods and the inclusion of Vitamin B12 in one of the therapy combinations. In our study, ninety-one participants were divided into three groups: one receiving routine acupuncture, another using electroacupuncture, and a third receiving a combination of electroacupuncture and Vitamin B12 injections along with local anesthetics.
Each therapy was administered over twenty sessions within a month. We measured changes in blood flow in the vertebral and basilar arteries and evaluated the participants' symptoms and overall function related to their vertigo. While all treatment methods showed some positive effects, the combination therapy, which included Vitamin B12, stood out as being the most effective.
This suggests that Vitamin B12 might play a significant role alongside acupuncture methods in treating cervical vertigo. However, it’s important to note that the specific impact of Vitamin B12 alone wasn’t isolated in this study, leaving us to consider its effects within the broader context of combined therapies.
Each therapy was administered over twenty sessions within a month. We measured changes in blood flow in the vertebral and basilar arteries and evaluated the participants' symptoms and overall function related to their vertigo. While all treatment methods showed some positive effects, the combination therapy, which included Vitamin B12, stood out as being the most effective.
This suggests that Vitamin B12 might play a significant role alongside acupuncture methods in treating cervical vertigo. However, it’s important to note that the specific impact of Vitamin B12 alone wasn’t isolated in this study, leaving us to consider its effects within the broader context of combined therapies.
9.5
Vertigo resolution
Most Useful Review
Excellent! for vertigo.
Anemia
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.8
USERS' SCORE
Good
Based on 58 Reviews
8.6
9
Vitamin B12 effectively treats anemia
An Unusual Case of Hemolytic Anemia: A Case Report.
Most Relevant Research
We observed a compelling case surrounding the impact of vitamin B12 on anemia, particularly in a 62-year-old man facing severe deficiencies due to factors like drug use, hepatitis C, smoking, and alcoholism. Initially, this patient presented with symptoms such as fatigue, fever, and confusion, raising concerns about more critical conditions like thrombotic thrombocytopenic purpura (TTP). Laboratory tests indicated severe pancytopenia and signs of hemolysis, making the situation quite alarming.
However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.
This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.
However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.
This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.
9.5
Effective for anemia
Most Useful Review
I found this form of B12 to be effective. After dealing with blood cancer-related pernicious anaemia and declining haemoglobin levels, I researched B12 and discovered the activated version. Within a week of using this, my haemoglobin levels stabilised and eventually improved. While it's not the sole treatment needed for red blood cells, it is vital. Many doctors seem unaware of the importance of activated B12 for red blood cell formation.
Cardiovascular Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 4 Reviews
8.6
8
Vitamin B12 reduces cardiovascular risks
Association of MTHFR C677T, MTHFRA1298C, and MTRRA66G Gene Polymorphisms with Hyperhomocysteinemia and Its Modulation by the Combined Effect of Vitamin B12 and Folate in Chinese Population with Hypertension.
Most Relevant Research
We explored the connection between vitamin B12, genetic factors, and cardiovascular health in a group of Chinese adults suffering from hypertension. By analyzing the genetic variations of individuals, we aimed to understand how these may influence levels of homocysteine, an amino acid that can impact heart health when present in high amounts.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
9.5
Improved red blood cells
Most Useful Review
This form of B12 genuinely works, as our lab results confirmed. While dealing with pernicious anaemia linked to blood cancer, I found traditional B12 ineffective. Once we began using this activated version, we observed a halt in the decline of hemoglobin levels, eventually seeing improvement. Regular use kept my red blood cell count above 8.5. It's vital for the formation of red blood cells, and many doctors underestimate its importance, despite the need for sufficient iron.
Ear Infection
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 13 Reviews
8.6
9.5
Improved hearing
Most Useful Review
I experienced muffled hearing in one ear, and after consulting a doctor, I was prescribed various medications, including B12. Research indicated that B12 could benefit my hearing, so I continued taking it. I'm pleased with how inexpensively I could purchase it from iHerb. Since starting this supplement, my ear problems have improved and haven't recurred. Early treatment for hearing issues is crucial; see a doctor if anything feels off.
Heart Disease
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.8
USERS' SCORE
Good
Based on 6 Reviews
8.6
9
Vitamin B12 helps heart recovery
Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.
Most Relevant Research
We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
9
Pain relief
Most Useful Review
B12 is of excellent quality with quick delivery to the postamat. The capsules are convenient for oral intake. After experiencing incessant back pains around my heart post-coronavirus, I took this on my doctor's recommendation. The taste is pleasant, with high purity ingredients. I've noticed my back pain has ceased, and my energy levels have surged within a week of use. It contains 1,500 mcg of B12.
Liver Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.7
USERS' SCORE
Good
Based on 5 Reviews
8.6
9
Methylcobalamin aids liver health
Methylcobalamin protects against liver failure via engaging gasdermin E.
Most Relevant Research
We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
9.5
Improved blood count
Most Useful Review
This form of B12 genuinely works, as confirmed by lab results. I struggled with liver disease and pernicious anaemia, leading to severe drops in haemoglobin. After changing to this methylated B12, my haemoglobin levels stabilised and even began to rise. This product, alongside iron supplements, has been crucial in managing my red blood cell count, which has remained above 8.5.
Sciatica
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 13 Reviews
8.6
9
Vitamin B12 helps alleviate sciatica
Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.
Most Relevant Research
We conducted a double-blind, randomized, placebo-controlled study to explore the effectiveness of intramuscular vitamin B12 in treating low back pain, including cases of sciatica. A total of 60 patients between the ages of 18 and 65, all suffering from mechanical lumbago or sciatic neuritis, participated in the study over a period of time. Each patient had a solid medical history of back pain lasting from 6 months to 5 years, with significant pain intensity measured on a scale.
Throughout the study, both groups showed notable reductions in pain and disability. However, when we compared the active treatment with the placebo, the results favored vitamin B12 significantly; the differences were strikingly marked in measurement tools used for assessing pain and disability. Furthermore, the placebo group reported higher consumption of paracetamol compared to those receiving vitamin B12, indicating that this vitamin could effectively alleviate pain and the need for additional pain relief medications.
Overall, our findings support the potential of vitamin B12 injections in managing low back pain and sciatica for those without signs of nutritional deficiency.
Throughout the study, both groups showed notable reductions in pain and disability. However, when we compared the active treatment with the placebo, the results favored vitamin B12 significantly; the differences were strikingly marked in measurement tools used for assessing pain and disability. Furthermore, the placebo group reported higher consumption of paracetamol compared to those receiving vitamin B12, indicating that this vitamin could effectively alleviate pain and the need for additional pain relief medications.
Overall, our findings support the potential of vitamin B12 injections in managing low back pain and sciatica for those without signs of nutritional deficiency.
10
Pain relief achieved
Most Useful Review
It has been 7 months since I began taking vitamin B12 for my sciatica, which was initially so severe that I couldn't walk. After 4 months, the pain had almost disappeared, and now I feel no pain at all. I used to suffer from this hernia-related pain every day for nearly two years. I still take it daily after meals, as it’s a small capsule that's easy to swallow. I highly recommend it for anyone dealing with nerve pain!
Chemotherapy
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Effective neuropathy remedy
Most Useful Review
Affordable and effective. These are energising. I have chemotherapy-induced peripheral neuropathy and these are very effective and affordable, a necessity for me. I’m delighted I found them after considerable trial and error. Five stars.
Athlete’s Foot
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Reduced numbness
Most Useful Review
I took this for numbness in my left hand and foot, and it has significantly reduced the numbness.
Autoimmune Disorder
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.8
USERS' SCORE
Good
Based on 32 Reviews
8.5
9
Pernicious anemia treatment effectiveness
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
Most Relevant Research
We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
9.5
Muscle relaxation benefits
Most Useful Review
For nerve and muscle relaxation, this easily digestible form works excellently. I have been drinking it for over a year, experiencing reduced body aches and irritability. B12 helps relax muscle fibres, relieving tensions. My nails improved too; white spots indicated a lack of B12. I would have avoided many issues had I started this sooner; it truly impacts the nervous system positively.
Heart Attack
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
3
USERS' SCORE
Good
Based on 8 Reviews
8.5
4
Vitamin B12 shows no heart attack benefit
Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial.
Most Relevant Research
In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
9.5
Seizure stability
Most Useful Review
After surviving a heart attack in September 2019, I faced a recurrence shortly after. Following the recommendation of a book by Dr. Mitsuishi and Dr. Fujikawa, I began taking this supplement. Since then, I haven’t experienced any further seizures, and my wife's “trigger finger” has improved. I'm unsure which supplement is responsible as I was using several, but I appreciate the benefits we’ve noticed.
Migraine
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.7
USERS' SCORE
Good
Based on 1 Review
8.5
7
Vitamin B12 deficiency and migraines
The correlation between vitamin B12 serum levels and migraine: a case-control study.
Most Relevant Research
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
8.8
Reduced migraine frequency
Most Useful Review
Fewer migraines, happier household! My doctor recommended B12 for my migraines, and I chose this brand. I experienced no stomach discomfort and found my migraines became less frequent. I'm so pleased I gave this a try, resulting in fewer migraines and a happier home.
Anxiety
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.8
USERS' SCORE
Good
Based on 25 Reviews
8.3
8
Vitamin B12 may reduce anxiety
Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach.
Most Relevant Research
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
9.5
Anxiety improvements
Most Useful Review
This is my repeat order. It is highly absorbable with no chemical ingredients. I've been taking it for my chronic anxiety and depression, and after three months, my neurological symptoms have greatly improved.
Irritable Bowel Syndrome
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 1 Review
8.3
8
Dietary guidance aids IBS management
Effects of dietary guidance on the symptoms, quality of life and habitual dietary intake of patients with irritable bowel syndrome.
Most Relevant Research
We examined how dietary guidance affects irritable bowel syndrome (IBS) symptoms and quality of life, particularly focusing on vitamin B12 intake. Our study involved 46 patients diagnosed with IBS based on established criteria, with 17 completing the entire program.
Through three sessions of personalized dietary advice, each lasting about 45 minutes, we found a significant reduction in IBS symptoms after the patients implemented the dietary changes. Their quality of life scores also improved notably. Although we noted an increase in vitamin B12 intake, it's important to emphasize that we did not isolate its effects from those of other dietary changes.
Interestingly, while our guidance helped patients enhance their overall nutrient intake, including vitamins and minerals, the increase in vitamin B12 specifically was the only change that reached statistical significance. However, we found no substantial differences in overall caloric or macronutrient intake among the participants.
In conclusion, while dietary guidance showed promising benefits for managing IBS symptoms and overall life quality, the impact of vitamin B12 alone remains unclear, as other dietary modifications may have played a role. Our findings suggest that individualized dietary counseling is a viable option in IBS management.
Through three sessions of personalized dietary advice, each lasting about 45 minutes, we found a significant reduction in IBS symptoms after the patients implemented the dietary changes. Their quality of life scores also improved notably. Although we noted an increase in vitamin B12 intake, it's important to emphasize that we did not isolate its effects from those of other dietary changes.
Interestingly, while our guidance helped patients enhance their overall nutrient intake, including vitamins and minerals, the increase in vitamin B12 specifically was the only change that reached statistical significance. However, we found no substantial differences in overall caloric or macronutrient intake among the participants.
In conclusion, while dietary guidance showed promising benefits for managing IBS symptoms and overall life quality, the impact of vitamin B12 alone remains unclear, as other dietary modifications may have played a role. Our findings suggest that individualized dietary counseling is a viable option in IBS management.
6.8
Clearer bowel movements
Most Useful Review
I understand that vitamin B is crucial for metabolism. After not taking it for a while, I noticed that resuming my intake led to clearer bowel movements, highlighting its necessity for me. The capsule size is smaller than other supplements, which makes me question if I’m getting enough. However, as the body excretes any excess, one capsule a day suffices for my needs.
Sleep Apnea
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 17 Reviews
8.3
9.5
Reduced insomnia
Most Useful Review
Fabulous! I no longer experience restless legs at night and enjoy a peaceful sleep. Perhaps this product is the reason? I hope so!
Tinnitus
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 22 Reviews
8.2
8.8
Reduced tinnitus
Most Useful Review
I took this for my tinnitus, and when combined with zinc, the high-pitched noise in my ears diminished significantly. The quality of the ingredients appears adequate, and the small capsules are easy to swallow, with no taste or odour. It is effective for early tinnitus and seems beneficial for the nervous system. Although it contains 180 tablets, I suggest repackaging them in a smaller bottle.
Headache
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 24 Reviews
7.9
8
Vitamin B12 deficiency linked to migraines
The correlation between vitamin B12 serum levels and migraine: a case-control study.
Most Relevant Research
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
9.5
Effective headache relief
Most Useful Review
Eating this every day prevents headaches. If I forget, I experience pain, so it truly is effective.
Pelvic Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 1 Review
7.8
1
Ineffective for pain
Most Useful Review
Disappointment 😞 It did not help with my pelvic pain like the Natural Factors brand at 5000 mcg. I took 10 capsules daily to match the dosage but found no relief. Even trying to dissolve the capsule under my tongue was unsuccessful.
