NOW Supplements Vitamin C Crystals Ascorbic Acid

Vitamin C mitigates flu pneumonia

A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice.

Most Relevant Research

We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.

However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.

Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.

Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.

Prevented flu altogether

Most Useful Review

Vitamin C is crucial for my health and wellbeing, particularly in its crystalline form. I appreciate this product as it dissolves easily, making it a pleasant experience to consume. I have been using this brand for about a year with excellent results, but I have taken Vitamin C supplements for over 64 years, and remarkably, I have never contracted the flu. I take massive doses of 8,000 to 10,000 mg daily and feel great. As I approach my 80th birthday on 14th April, I remain medication-free, and I thank the Almighty Creator every day.

Allergies

Pleuran and Vitamin C aid asthma

Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma.

Most Relevant Research

We conducted a thorough evaluation of how vitamin C, when combined with pleuran, impacts asthma control and respiratory issues in children suffering from perennial asthma. The study was meticulously designed as a double-blind, placebo-controlled trial involving 230 children aged 7 to 17 years. This means that neither the participants nor the researchers knew who was receiving the active treatment or the placebo, ensuring the findings were reliable.

The results were promising, especially for children under 12 years. They showed significant improvements in asthma control compared to those receiving only the placebo treatment. Meanwhile, older children (12 years and above) experienced fewer respiratory infections with the combination treatment. Overall, by the end of the 48 weeks, a majority of children on the pleuran and vitamin C treatment reported better asthma control compared to those on the placebo.

While the combination of pleuran and vitamin C was indeed beneficial for managing asthma, we must note that the study did not specifically isolate the effect of vitamin C alone on allergies or asthma. Thus, it is hard to draw definitive conclusions about vitamin C's effectiveness independently from pleuran. However, the approach suggested that using these supplements together could offer a helpful boost in managing asthma symptoms.

9.5

No side effects

Most Useful Review

Excellent quality! This powder does not cause allergies for my wife, who is often sensitive. It has no side effects and is recommended for those with sensitivities.

Anemia

Vitamin C aids anemia treatment

The Forgotten Disease in the 21st Century: Scurvy Outbreak in Hawassa Central Prison, Hawassa, Sidama, Southern Ethiopia, 2023.

Most Relevant Research

We observed a fascinating phenomenon related to vitamin C and anemia during a series of cases in a prison setting in Ethiopia. Specifically, we examined how scurvy, a disease caused by a lack of vitamin C, contributed to anemia among prisoners.

Our study focused on ten patients who were admitted for treatment, all of whom presented with some form of leg swelling or pain. After administering vitamin C in the form of ascorbic acid, we noted a significant increase in hemoglobin levels, rising from an average of 4.6 to 7.1 g/dL. This improvement indicates that vitamin C may play a crucial role in alleviating some anemia symptoms when the underlying cause is related to dietary deficiencies.

Additionally, through an observational study involving 67 other patients in the same prison, we confirmed that leg swelling and pain were common symptoms among those affected. With consistent therapeutic doses of vitamin C, all patients showed considerable improvement in their conditions.

Thus, we can conclude that vitamin C does seem to have a valuable effect on anemia caused by dietary deficiencies, particularly in high-risk environments like prisons. This finding encourages healthcare providers to remain vigilant about such nutritional deficiencies and highlights the importance of vitamin C in treatment.

9.5

Increased iron levels

Most Useful Review

I purchased this to take alongside iron supplements as recommended by a professor, due to my lifelong struggle with anemia. Indeed, this method effectively and rapidly raises iron levels in the blood. Vitamin C helps oxidise iron for better absorption in the body. There’s plenty of powder in the jar to last a long time, and I sometimes add it to tea for a bit of tang. A quality product!

Chronic Cough

An excellent tool for supporting immunity. Normally, I catch a cold and develop a chronic cough every spring and autumn. However, this spring, despite the poor weather, intense training, and strict diet, I have remained well. I credit this improvement to vitamin C. Even though recent studies suggest otherwise, the results speak for themselves. Everyone around me is sniffling, yet I feel fine. I take 2-5 grams daily and prefer buying from Now, as they offer the best value for money.

Influenza

Vitamin C's unclear influenza impact

Based on 6 Researches

The Role of Some Vitamins in Respiratory-related Viral Infections: A Narrative Review.

Most Relevant Research

We explored the relationship between vitamin C and influenza, delving into various studies conducted from 2000 to June 2021. In our analysis of the research, we found eleven studies that specifically examined the effects of vitamin C on influenza.

While some of these studies reported positive outcomes, we should note that the isolated benefits of vitamin C can be hard to determine. This is primarily because some studies included additional treatments, making it difficult to draw definitive conclusions about vitamin C alone.

Overall, we observed that while there is some interest and preliminary evidence regarding the efficacy of vitamin C in preventing or treating influenza, its stand-alone effectiveness remains somewhat unclear.

Continued research should help clarify how much vitamin C can truly contribute to combating influenza.

9.5

Cold prevention

Most Useful Review

I've been taking vitamin C with other supplements for several years and it has helped me stay clear of colds and influenza. The sour taste is not an issue for me.

Leg Cramps

Leg cramps treatment comparison

Calcium and magnesium status in pregnant women. A comparison between treatment with calcium and vitamin C in pregnant women with leg cramps.

Most Relevant Research

We explored the effects of vitamin C on leg cramps in a group of 60 pregnant women through a double-blind trial. Participants received either calcium or vitamin C (1 g twice daily) as treatment. Our observations revealed that there was no significant difference in clinical improvement between the two treatment groups.

Notably, 14 patients experienced complete relief from symptoms, while 27 reported significant improvement regardless of which treatment they received. Unfortunately, 17 participants found their symptoms unchanged, and only two noticed an increase in leg cramps during the treatment period.

Throughout the study, we measured serum levels of total and ionized calcium, total magnesium, and albumin, but these parameters did not show significant changes in either treatment group. We also didn’t identify any biochemical differences when comparing the effectiveness of vitamin C and calcium for alleviating cramps.

Ultimately, our findings suggest that vitamin C may not be an effective solution for leg cramps in pregnant women, as both treatments yielded similar results with minimal biochemical changes.

9.5

Reduced leg cramps

Most Useful Review

During my pregnancy, I began taking Vitamin C after reading the Better Baby Book. I take 6g per day, using crystals for easier intake. Vitamin C has been shown to greatly reduce leg cramps, improve blood iron levels, and enhance baby health. I rarely suffer from leg cramps and have no stretch marks in my eighth month. It’s essential to adjust doses gradually, so I ensure I take my crystals daily in three doses.

Sinusitis

Vitamin C aids chloride transport

Effect of L-ascorbate on chloride transport in freshly excised sinonasal epithelia.

Most Relevant Research

We explored the effects of L-ascorbate, commonly known as Vitamin C, on chloride transport in sinonasal epithelial tissues. This research is particularly significant as it addresses the common condition of chronic rhinosinusitis (CRS) and its potential link to the function of the cystic fibrosis transmembrane conductance regulator (CFTR) — a key chloride ion channel.

During our investigation, we utilized freshly excised sinonasal tissues from both normal individuals and patients suffering from CRS. The tissues were carefully prepared and tested to understand how L-ascorbate influenced chloride secretion. Our findings revealed that the application of L-ascorbate notably enhanced chloride secretion in these tissues.

This is important because optimal chloride transport is essential for maintaining healthy mucosal surfaces and effective mucociliary clearance. Therefore, since decreased chloride secretion could lead to the worsening of sinus conditions, L-ascorbate presents a promising avenue for therapeutic intervention in improving mucociliary clearance for those affected by chronic sinus issues.

Sinusitis improvement

Most Useful Review

I love it! I bought a 1g spoon, put it in a container, and take it each morning and evening. Initially, my child struggled to switch from pills to powder, but now he enjoys it with soy milk. He rarely catches a cold and recovers quickly; I used to suffer from sinusitis but it vanished after starting megadoses of vitamin C. I should have bought this sooner!

Whooping Cough

It takes effect. When only warm, it followed with a cough, and only in larger amounts. It healed in one day.

Autoimmune Disorder

Vitamin C impacts autoimmune response

Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies.

Most Relevant Research

We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.

Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.

Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.

Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.

9.5

Boosted immunity

Most Useful Review

Excellent vitamin C! It has helped me immensely since my pregnancy. My body was weakened, leaving me prone to illness. I ordered vitamin C in crystals, which allows me to control the dosage easily. After taking it for four months, my frequent colds have disappeared, and I've regained my strength. I highly recommend it!

Bronchitis

Vitamin C aids bronchitis resistance

Based on 6 Researches

Ascorbic acid and infectious bronchitis infections in broilers.

Most Relevant Research

We explored how supplementing the diet of broiler chicks with different levels of vitamin C, also known as ascorbic acid, impacts their resistance to infectious bronchitis virus. The goal was to determine whether this supplement could help improve their health by measuring the severity of tracheal lesions and the presence of airsacculitis after exposure to the virus.

Our findings indicated that the effectiveness of vitamin C was dose-dependent. We observed that adding between 300 to 330 parts per million (ppm) of ascorbic acid to their feed yielded the best protective results. Interestingly, when we looked at higher concentrations—beyond 600 ppm—the benefits seemed to diminish. This suggests that while vitamin C can be beneficial, there's a suitable range for its effectiveness.

Overall, this study highlights the potential of vitamin C as a useful dietary addition for enhancing the health of broilers facing bronchitis. Yet, it's clear that more isn't always better when it comes to dosage, and finding that sweet spot is crucial for maximizing its effectiveness.

9.5

No bronchitis treatment

Most Useful Review

Great for everyday use, especially during cold and flu season! I gave some to my mum when she began to feel unwell. She had no energy and suffered from congestion. Typically, she develops bronchitis, but after two days of morning servings of these crystals, she was back on her feet without needing a doctor or pills. Fantastic!

Heart Disease

Vitamin C's uncertain heart benefits

Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1.

Most Relevant Research

We aimed to understand the role of vitamin C in heart disease and its potential cardioprotective effects. Vitamin C is renowned for its antioxidant properties, which means it fights off harmful substances in our body, potentially reducing the risk of heart issues.

Our analysis revealed that vitamin C could play a meaningful role in supporting cardiovascular health. While the evidence is promising, it is important to be cautious, as clinical studies have shown mixed results regarding its effectiveness.

So, while vitamin C might contribute positively to heart health, more solid evidence is required to fully confirm these effects. Overall, we learned that while there are positive indicators, we should be careful about over-relying on vitamin C as a sole preventive measure for heart disease.

Gums stopped bleeding

Most Useful Review

It's unfortunate that dentists often overlook the role of Vitamin C in treating heart disease and periodontal issues. After increasing my intake, my gums have ceased bleeding, which is a significant improvement. Reducing the dosage leads to bleeding again, so I notice a direct correlation to the Vitamin C. I appreciate Linus Pauling's advice, even if it causes some digestive discomfort.

Hypertension

Likely Very Effective

Vitamin C reverses pulmonary hypertension

Reversible severe pulmonary hypertension related to scurvy in children.

Most Relevant Research

We explored the intriguing connection between vitamin C deficiency and severe pulmonary hypertension (PH) in children. Our investigation focused on two young boys who experienced debilitating episodes of hypertension linked to their restrictive diets and scurvy.

In the first case, a 2-year-old faced symptoms like vomiting and hypotension. Despite initial treatment, he developed serious health complications, leading to a diagnosis of transient PH revealed through echocardiogram results. Upon discovering his low vitamin C levels, we treated him with vitamin C and observed a remarkable reversal of his hypertension.

The second case involved a 6-year-old boy who presented with acute breathing difficulties and joint swelling. Similarly, after confirming undetectable vitamin C levels, we started his treatment with vitamin C, which also led to rapid improvements in his pulmonary hypertension.

These findings emphasize that PH in children can arise from nutritional deficiencies like scurvy. It also highlights the importance of correctly diagnosing and treating these conditions, as vitamin C can effectively reverse hypertension associated with scurvy. Our report underscores the necessity of considering dietary factors in pulmonary hypertension cases and challenges us to look closely at patients' nutritional intake.

9.5

Pressure normalised

Most Useful Review

I have been taking it for two months. I struggled to manage my hypertension, but now my blood pressure is 120/80.

Knee Pain

Vitamin C for knee pain relief

Skeletal manifestations of scurvy: a case report from dubai.

Most Relevant Research

We observed an intriguing case involving a 4.5-year-old boy who developed significant knee pain due to a rare nutritional deficiency, scurvy. This condition stemmed from his exclusive intake of meat over the past two years, resulting in skeletal issues and inflammation in multiple joints, including his knees.

Upon examination, the child exhibited several symptoms, including pain, swelling, and an inability to walk. Standard blood tests primarily indicated anemia, but X-rays revealed alarming conditions related to scurvy, such as delayed bone age and severe osteopenia. This alarming picture led us to the conclusion that vitamin C deficiency was the underlying culprit behind his knee pain and skeletal issues.

After initiating vitamin C therapy, we noted a remarkable reduction in pain and swelling over the next two months. The child’s condition improved significantly, allowing him to walk again, and follow-up X-rays confirmed the positive changes in his bone health. This case clearly illustrates how vitamin C can effectively alleviate knee pain related to scurvy and reinforces the importance of proper nutrition for overall skeletal health.

Reduced joint pain

Most Useful Review

Joint pain and stiffness have significantly diminished for both me and my 60-pound Border Collie. We are very pleased with these results. I continue with this Vitamin C form, as I don't mind the taste, but my dog prefers sodium ascorbate due to taste issues. Importantly, this is a non-GMO product.

Liver Disease

Vitamin C reduces liver injury

The Effect of Ascorbic Acid on Hepatic Ischaemia-Reperfusion Injury in Wistar Rats: An Experimental Study.

Most Relevant Research

We evaluated how vitamin C, also known as ascorbic acid, can help protect the liver during procedures that temporarily cut off blood flow—a process known as ischaemia followed by reperfusion. In this study, we used thirty-six male Wistar rats, split into control groups and experimental ones. Each group received the same total dose of vitamin C, administered at different times: either before the ischaemia, before the reperfusion, or both.

Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.

This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.

8.8

Improved immunity

Most Useful Review

The antioxidant effect of megadosing vitamin C was beneficial for me; it was great value for the price. I believe that high doses of vitamin C help combat liver disease, as I feel less fatigued, my skin appears brighter, and my immunity seems to improve. My liver function was good, prompting my doctor to inquire about my supplements. To note, I also take low-carb vitamin C, high-dose glutathione, and additional items.

Lung Cancer

Vitamin C reduces lung cancer spread

Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway.

Most Relevant Research

We explored the effects of vitamin C on lung cancer, particularly its ability to inhibit pulmonary metastasis—meaning the spread of cancer to the lungs. Using an H22 pulmonary metastasis mouse model, we observed that vitamin C administration, both intraperitoneally and orally, showed promising results.

Through the research, we found that intraperitoneal injections of vitamin C led to an increase in crucial proteins like Nrf2 and HO-1, which are known to help combat cancer. This process resulted in increased cell death in cancer cells through DNA damage and apoptosis, mimicking the effects seen when using pro-oxidant treatments in cells lacking the p53 protein—a critical tumor suppressor.

Furthermore, oral vitamin C not only activated these protective pathways but also spurred the expression of p53 in healthy tumor cells, showcasing its potential as an antimetastatic agent. We noted that vitamin C reduced the proliferation and migration of lung cancer cells while being gentler on normal cells, suggesting a safer therapeutic profile.

Overall, this study highlights vitamin C's dual role in both bolstering the body's defenses against cancer and directly inhibiting the spread of lung cancer, paving the way for its consideration in clinical treatments for pulmonary metastasis.

Life-saving vitamins

Most Useful Review

After consuming these vitamins, two cancer patients are now leading normal lives. These supplements have been pivotal in their fight against lung cancer.

Tonsillitis

Simply the best! I previously took it in pill form, but this time I opted for the powder. I noticed an immediate effect for my chronic tonsillitis and sinusitis. I'm very satisfied with this vitamin C purchase!

Cold

Effectiveness of Vitamin C on Colds

Vitamin C for the common cold and pneumonia.

Most Relevant Research

We explored the effects of vitamin C on the common cold and pneumonia by examining a range of studies. Interestingly, research on animals suggests that vitamin C may have protective effects against infections. However, when it comes to preventing colds in the general population, taking more than 1 gram of vitamin C per day didn’t show significant benefits.

But there's a twist! Participants engaged in heavy physical activities saw their cold incidence reduced by half with vitamin C supplementation. Additionally, regular intake of 1 gram or more daily was linked to a 15% decrease in cold severity. While some therapeutic trials showed inconsistent results when vitamin C was taken after cold symptoms appeared, two studies did indicate that larger doses (6-8 grams per day) could effectively shorten the duration of colds compared to lower doses.

Our investigation also looked into pneumonia, but the studies were conducted in unique settings, such as a boarding school and military recruits. This makes it hard to generalize the findings to the wider population. Yet, some trials suggested benefits for pneumonia patients. Finally, the role of vitamin C in treating COVID-19 and sepsis remains unclear, with mixed results.

Given that vitamin C seems to alleviate symptoms and shorten the duration of colds, while being safe and affordable, it might be worth considering a dose of 6-8 grams per day to see if it helps at an individual level.

8.8

Gentle on stomach

Most Useful Review

Good stuff. I purchased the Now fine ascorbic acid powder a few weeks ago. It’s much easier on my stomach compared to the Nutri Biotic crystalline powder. If I ever feel a cold coming on, I take a teaspoon mixed with orange juice. I plan to take one level teaspoon every day, even in summer. I’ve looked into Linus Pauling, who took 14 grams of vitamin C powder every day and lived to 93.

Skin Cancer

I had a small basal cell carcinoma (BCC) on my face resembling photos of BCC found online. I mixed half a teaspoon of Vitamin C crystals with a teaspoon of water, creating a paste, which I applied to the BCC. This solution only caused stinging on the cancerous area, leaving the healthy skin unharmed. After applying it overnight and repeating for about two weeks, the stinging subsided, and the tumour crusted over and fell off, revealing healthy skin beneath. I hope to never need it again, but I have a good amount left.

Bloating

Vitamin C's impact on bloating

Associations Between Dietary Vitamin C, Serum Ascorbic Acid, and Genotype and Premenstrual Symptoms.

Most Relevant Research

We aimed to explore how different measures of vitamin C might influence premenstrual symptoms, particularly bloating. In this study, we analyzed data from 555 women aged 20 to 29 years who reported on various symptoms associated with their menstrual cycles. We looked at their dietary intake of vitamin C, measured serum ascorbic acid levels, and assessed genetic factors through DNA testing.

Our findings suggest that higher vitamin C status is linked to increased appetite changes and symptoms like bloating and swelling during the premenstrual phase. While we observed associations between vitamin C levels and these symptoms, it's important to note that our study didn't isolate the effect of vitamin C from other dietary influences. Therefore, while there's a connection between vitamin C and bloating, we cannot conclusively say that vitamin C alone is definitive in relief.

Overall, this research opens the door to understanding how nutrition, particularly vitamin C intake, may shape our experiences with premenstrual symptoms. However, it also highlights the complexity of diet's role in our health.

Effective for bloating

Most Useful Review

It may be oxidised due to the high dose, and as a megavitamin, I experienced some bloating initially. However, it has been beneficial in aiding my recovery from fatigue.

Breast Cancer

Vitamin C may reduce breast cancer

Based on 9 Researches

The association between vitamin C and breast cancer, prostate cancer and colorectal cancer: A systematic review and meta-analysis.

Most Relevant Research

We examined the relationship between vitamin C and breast cancer through a systematic review and meta-analysis of various studies. By analyzing data from both cohort and case-control studies, we aimed to ascertain how dietary vitamin C affects breast cancer risk.

Our findings reveal an interesting trend. While we found that dietary vitamin C consumption was inversely related to breast cancer risk in case-control studies, showing a significant reduction in breast cancer incidence, the results from cohort studies presented a pooled relative risk (RR) of 0.99. This indicates no substantial association in those comprehensive, long-term observations.

Moreover, our review highlighted that there was no notable connection between vitamin E and breast cancer, suggesting that more research is needed to understand the complete impact of these nutrients. Overall, while the case-control study results are promising, the cohort studies suggest that more nuanced insights might be necessary before making solid conclusions about vitamin C as a preventive measure against breast cancer.

9.5

Life-saving vitamins

Most Useful Review

After consuming this, I know two breast cancer patients who are leading normal lives. These vitamins transformed their health.

Bruise

Vitamin C improves bruising symptoms

Based on 9 Researches

Scurvy in the Modern World: Extinct or Not?

Most Relevant Research

We explored how vitamin C can impact bruising, particularly in individuals experiencing a deficiency. The research highlighted a case involving an elderly woman who faced challenges such as weakness, easy bruising, and fatigue due to a lack of this vital nutrient.

After beginning treatment with vitamin C supplements, we observed significant improvements in her symptoms, emphasizing the importance of this vitamin in healthier skin and tissue repair. It showcased that scurvy, a condition rooted in vitamin C deficiency, can still occur today, especially in certain at-risk populations.

This case reminds us that while scurvy might seem like a relic of the past, it can still affect modern individuals. Skin issues like easy bruising can sometimes signal deeper dietary concerns that need addressing, especially in older adults.

No more bruising

Most Useful Review

An excellent tool. At 60 years old, my gums stopped bleeding, and the bruising disappeared. My general health has improved. I recommend it. If this review was helpful, please like it. Thank you!

Cardiovascular Disease

Vitamin C enhances NK cell proliferation

Based on 4 Researches

Proliferation capability of natural killer cells upon cytokines stimulation correlated negatively with serum lactate dehydrogenase level in coronary artery disease patients.

Most Relevant Research

We explored the effects of vitamin C on natural killer (NK) cell activity in patients with coronary artery disease (CAD). Our research involved isolating NK cells from 29 CAD patients and treating them with various stimulatory factors, including ascorbic acid—better known as vitamin C.

What we found was quite interesting: when NK cells were treated with ascorbic acid, there was a significant increase in their ability to proliferate. This meant that the NK cells were more active and potentially more effective in responding to threats in the body, which is vital for those dealing with heart conditions.

Furthermore, we measured serum lactate dehydrogenase (LDH) levels, discovering a negative correlation between LDH and NK cell activity. Higher LDH levels seemed to indicate lower proliferation capability in NK cells influenced by interleukins.

Overall, our study suggests that vitamin C could play a positive role in enhancing immune function in CAD patients by promoting NK cell proliferation. However, it's important to note that while vitamin C shows promise, further research is needed to fully understand its impact on cardiovascular health and immune regulation.

8.8

Preventing illness

Most Useful Review

Fantastic product! Our family has benefited immensely from this over the years. My young son has type 1 diabetes, and it's frightening when he gets sick. We take large doses of vitamin C at the first sign of illness and rarely see any sickness in our home now, even with our two little ones. It's made in the USA and is non-GMO. We mix it with a stevia-based water enhancer that the kids enjoy, as it tastes like juice. I hope this helps others looking for an excellent product.

Depression

Vitamin C intake linked to depression

Based on 10 Researches

Association of dietary vitamin C intake with depression in adults: A cross-sectional study of NHANES from 2005 to 2020.

Most Relevant Research

This study aimed to understand how dietary vitamin C affects depression in adults. By analyzing data from the National Health and Nutrition Examination Survey spanning from 2005 to 2020, we focused on the relationship between vitamin C intake and depression levels among 38,157 participants.

Our findings revealed that individuals who consumed higher amounts of vitamin C had lower odds of experiencing depression. Specifically, those in the higher intake quartiles showed significantly reduced odds compared to those with the lowest intake. Interestingly, we discovered an L-shaped curve representing the relationship between vitamin C and depression, suggesting that while increased intake was beneficial up to a certain point (around 93.61 mg), higher consumption did not yield additional benefits.

While our results are promising, it's crucial to note that this was a cross-sectional study, meaning we cannot definitively claim that vitamin C intake causes changes in depression. Additionally, other factors might have influenced these associations, which we couldn't fully control for.

Overall, this research provides intriguing evidence of the potential role that dietary vitamin C might play in alleviating depressive symptoms, especially for those consuming lower amounts.

9.5

Improved depression

Most Useful Review

Vitamin B12 supplements should be methylcobalamin, as it is better absorbed than cyanocobalamin, especially for those with IBS. It's excellent; I strongly recommend it. It has raised my B12 levels and helped treat my depression.

Floaters

Vitamin C may improve floaters

Dietary Intervention With a Targeted Micronutrient Formulation Reduces the Visual Discomfort Associated With Vitreous Degeneration.

Most Relevant Research

We aimed to explore how a specific micronutrient formulation, including vitamin C, impacts visual discomfort caused by vitreous floaters. In a clinical trial, 61 patients experiencing symptoms of floaters were divided into two groups. One group took an active supplement containing various ingredients, including 40 mg of vitamin C, while the other group received a placebo over a period of six months.

After this period, we observed a significant reduction in visual discomfort among those who took the active formulation, compared to the placebo group, which experienced no noticeable changes. Additionally, the group taking the supplement showed a remarkable decrease in vitreous opacity, a key factor associated with floaters.

The positive effects were further validated through improvements in specific visual functions, such as contrast sensitivity. These findings suggest that vitamin C, as part of a targeted micronutrient strategy, may support patients suffering from visual disturbances, enhancing their overall quality of life.

This study highlights the potential benefits of dietary interventions alongside conventional treatments for symptomatic vitreous degeneration.

Remarkable improvement

Most Useful Review

AWESOME!!!!! It's really good to say a million times how impressive all the products are. I began taking Vitamin C in powder form and noticed an improvement in my skin and better bowel activity. I feel great each morning throughout the day. The difference when using the powder compared to tablets is significant. I'm very satisfied and will definitely repurchase.

Frozen Shoulder

Vitamin C shows promise against frozen shoulder

Vitamin C as a Potential Prophylactic Measure Against Frozen Shoulder in an In Vivo Shoulder Contracture Animal Model.

Most Relevant Research

In our controlled laboratory study, we aimed to investigate whether vitamin C could help prevent frozen shoulder, particularly the secondary type that often occurs after trauma or surgery. We created a shoulder contracture model using Sprague-Dawley rats, which involved immobilizing their right shoulder.

Our experimental group, consisting of eight rats, received vitamin C orally, while a control group of nine rats did not receive vitamin C. We primarily measured the thickness of the joint capsule at the shoulder using magnetic resonance imaging (MRI).

The results were promising, indicating that vitamin C may reduce the thickening of the joint capsule linked to secondary frozen shoulder. Although we also conducted histological examinations, we did not perform statistical analysis on those findings due to variability in our cutting techniques.

This preclinical study suggests that vitamin C could be a valuable, non-invasive way to prevent secondary frozen shoulder, particularly in situations involving surgery or immobilization. However, more research is needed to determine its effects on humans and establish proper dosage guidelines.

8.8

Effective treatment

Most Useful Review

Good, it’s effective. I used it for my frozen shoulder, and it worked, but I also did additional things.

Heart Attack

Antioxidants tested for heart attacks

Safety and Pharmacokinetics of a Combined Antioxidant Therapy against Myocardial Reperfusion Injury: A Phase 1 Randomized Clinical Trial in Healthy Humans.

Most Relevant Research

In a recent clinical trial, we examined how a combination of antioxidants, including vitamin C, affects heart attack recovery. This study involved healthy participants who received either a blend of antioxidants or a placebo through an intravenous infusion. We measured the levels of vitamin C and other components in the blood, looking for signs of oxidative stress and monitoring any adverse effects.

Our findings showed that the antioxidant combination significantly increased vitamin concentrations compared to the placebo group. Moreover, we observed that this therapy seemed safe, with only mild, non-serious side effects reported in a small number of participants.

While antioxidants like vitamin C have been linked to health benefits, this study focused primarily on their safety and levels in the blood during a heart-related procedure. Although promising, we cannot definitively say that this approach improves outcomes for heart attack patients just yet. More research will be needed to explore its effectiveness further.

8.8

Heart health improvement

Most Useful Review

Linus Pauling may be right. I have gone through three 3-pound tubs, and it hasn’t harmed me; in fact, I could still eat and might be clearing my arteries! After three years, my nuclear stress test now shows normal results regarding my heart health.

Hypothyroidism

Vitamin C may lower hypothyroidism risk

Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007-2012.

Most Relevant Research

We set out to examine how total vitamin C intake might influence hypothyroidism in individuals with Hashimoto thyroiditis, using data from the National Health and Nutrition Examination Survey conducted between 2007 and 2012. Our study utilized multivariate logistic regression and restricted cubic spline analyses to uncover possible associations.

What we found was quite intriguing. There was a clear negative linear relationship between total vitamin C intake and hypothyroidism. Specifically, participants who consumed higher amounts of vitamin C had a significantly lower likelihood of developing hypothyroidism. Those in the top quartile of vitamin C intake were about 60% less likely to have hypothyroidism compared to those in the lowest quartile.

This pattern remained consistent across different age groups and sexes, further emphasizing the potential benefits of vitamin C for individuals with Hashimoto's. Our findings suggest that increasing vitamin C intake may be a simple and effective strategy for reducing the risk of hypothyroidism in those affected. The data indicates that consuming between 4.57 and 1258.9 mg/day of vitamin C could be beneficial.

Overall, our research adds to the understanding of how antioxidants like vitamin C can play a role in thyroid health, encouraging us to consider dietary sources of this vital vitamin for those managing Hashimoto's thyroiditis.

Adrenal support

Most Useful Review

It's easy to take; I mix it with water or juice. I consume 2.5g daily for adrenal support, as I have hypothyroidism. iHerb offers a great price for a reliable brand.

Insomnia

Vitamin C alleviates chemotherapy insomnia

Relief from cancer chemotherapy side effects with pharmacologic vitamin C.

Most Relevant Research

We explored the effects of pharmacologic vitamin C on insomnia related to cancer chemotherapy. In our case study, we worked with a woman battling recurrent breast cancer who was experiencing significant fatigue and lethargy as she underwent weekly chemotherapy sessions.

To combat her sleep disturbances, we administered high doses of vitamin C, 50 grams per session, twice a week. We also employed quality of life and fatigue questionnaires to monitor changes over time.

The results were promising! We observed marked improvements in her insomnia and overall fatigue levels. Furthermore, there was a notable enhancement in her cognitive functioning, without any adverse side effects from the vitamin C treatment.

This case highlights how vitamin C may offer relief from insomnia associated with chemotherapy, providing a new avenue for improving quality of life during cancer treatment.

Increased energy

Most Useful Review

Very little is needed—just 1/4 teaspoon lasts a long time. It helps me wake up in the mornings, and I've stopped drinking coffee. I drink a glass during the day; it quickly leaves the body, which makes it beneficial to spread out its effects. I once had a sore throat, and upon drinking it at night, the soreness disappeared, but I experienced insomnia. Therefore, I recommend taking it before 5 PM. I also give it to my children, aged 8 and 2.

Prostate Cancer

Vitamin C shows promise in cancer treatment

Based on 14 Researches

Pharmacological Vitamin C Treatment Impedes the Growth of Endogenous Glutamine-Dependent Cancers by Targeting Glutamine Synthetase.

Most Relevant Research

We examined how vitamin C (VC) affects prostate cancer cells, particularly those reliant on glutamine for growth. Our study involved both prostate cancer cell lines and mouse models to understand the therapeutic potential of VC in this context.

We discovered that vitamin C has the ability to target an enzyme known as glutamine synthetase (GS), crucial for cancer cell survival. By degrading GS, VC induces oxidative stress, which appears to be detrimental to the cancer cells. We used both traditional lab approaches and more advanced imaging techniques to monitor the treatment's effectiveness, and found a direct correlation between GS levels and the cytotoxic effects of VC.

Not only did our experiments demonstrate that VC boosts the production of reactive oxygen species (ROS), but they also revealed that its effects could be mitigated by antioxidants, highlighting its mechanism of action. Particularly compelling were results from the mouse models, where VC treatment showed more pronounced effects in cancer cells overexpressing GS, suggesting a tailored approach to treatment might be effective.

Overall, these findings point to the potential of vitamin C as a novel treatment option for endogenous glutamine-dependent prostate cancers, emphasizing its role in targeting the metabolic pathways vital for tumor cell growth.

Life-saving vitamins

Most Useful Review

After consuming these vitamins, two cancer patients are now leading normal lives. They played a crucial role in their recovery.

Psoriasis

DDH-1 shows psoriasis improvement

Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression.

Most Relevant Research

We explored the potential of DDH-1, a unique derivative of ascorbic acid, in treating psoriasis, a chronic inflammatory skin condition driven by certain cytokines. In our research, mice with psoriasis-like skin lesions induced by imiquimod were treated with DDH-1 to examine its effects on inflammatory markers.

During our study, we found that treatment with DDH-1 significantly reduced the expression of inflammatory cytokines IL-1β and TNF-α in the affected skin. This finding is crucial, as these cytokines are key players in the development and persistence of psoriasis.

Additionally, we observed noticeable improvement in the skin lesions of the mice following the application of DDH-1. These promising results indicate that DDH-1 may be beneficial for those looking to manage psoriasis and could serve as a supplement in treatment strategies.

8.8

Improved skin condition

Most Useful Review

Excellent! It's easy to drink and dissolves quickly in water, tasting just like lemon water. I'm pleased with the ample quantity provided. After giving it to my child, my dry arms and red psoriasis arms improved significantly within a week. The entire family is delighted.

Basal Cell Carcinoma

Effective treatment method

Most Useful Review

I had a small basal cell carcinoma (BCC) on my face that appeared dark with a hard crust, matching photos I found online. I mixed half a teaspoon of Vitamin C crystals with a teaspoon of water, storing it in a small jar until it somewhat dissolved. Using a Q-tip, I mixed it further into a sludge and applied it to the BCC. The solution only causes stinging on the cancerous growth, leaving the healthy surrounding skin unaffected. I left it on overnight and continued for about two weeks. Eventually, the stinging ceased, and the tumour crusted over, falling off to reveal healthy skin beneath. I hope I never need it again, but I've got plenty left over!

Cancer

Vitamin C enhances immune response

Likely Very Effective

Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response.

Most Relevant Research

We delved into how vitamin C might influence cancer treatment, focusing on its effects on the immune system. Our findings revealed that vitamin C directly modifies certain proteins, leading to a new type of protein change called vitcylation. This process specifically affects a protein known as STAT1.

By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.

Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.

9.5

Removed cancerous growth

Most Useful Review

I had a small basal cell carcinoma (BCC) on my face and recognised its symptoms from online images. I mixed Vitamin C crystals with water to create a paste and applied it with a Q-tip. This paste caused stinging on the cancerous growth, leaving healthy skin unaffected. After two weeks, the stinging stopped, and the tumour crusted over and fell off, revealing healthy skin beneath. I hope to never need this remedy again, though I have plenty left just in case.

Cold Sores

Vitamin C alleviates cold sores

Topical treatment of recurrent mucocutaneous herpes with ascorbic acid-containing solution.

Most Relevant Research

We investigated how an ascorbic acid-based solution could help treat recurrent cold sores, also known as mucocutaneous herpes. This study was carefully designed as a randomized, double-blind, placebo-controlled trial, which helps ensure the results are reliable and trustworthy.

Participants used a strong solution of Ascoxal, rich in vitamin C, applied to their cold sores multiple times on the first day of the outbreak. We monitored various symptoms daily, including the severity of scabs, redness, and blisters, comparing the experiences of those using the vitamin C solution to a placebo group.

Our findings were promising: the active treatment resulted in fewer days with scabbing and less severe symptoms overall. Moreover, those using the vitamin C solution showed reduced persistence of scabs compared to the placebo group, along with a lower frequency of detected herpes virus after treatment.

In conclusion, this brief course of vitamin C treatment appears to have significant clinical benefits against cold sores, opening the door for future research on more extensive and frequent treatment regimes.

9.5

Prevention expert

Most Useful Review

I always keep this product in my medicine cabinet. It has made me forget about lingering colds and sore throats. I take a teaspoon daily for prevention and increase to 3-4 doses when I have cold sores. It helps thin the blood!

Food Poisoning

Vitamin C alleviates food poisoning

Vitamin C alleviates acute enterocolitis in Campylobacter jejuni infected mice.

Most Relevant Research

To explore the effects of vitamin C on food poisoning caused by Campylobacter jejuni, we conducted a study using mice specifically bred to develop a condition similar to human campylobacteriosis. Mice were treated with synthetic vitamin C in their drinking water starting four days before they were infected with the bacteria. Our goal was to see if this treatment could lessen the severity of their symptoms.

Over the course of our research, we found that the mice receiving vitamin C had lower levels of the bacteria in their intestines. They also experienced less severe inflammation and other symptoms associated with infections. Interestingly, the benefits of vitamin C extended beyond just the intestines; we noticed reduced inflammatory responses in other organs such as the liver, kidneys, and lungs.

This suggests that vitamin C could be a promising option for both preventing and treating acute campylobacteriosis. Our findings highlight the potential health benefits of this vitamin and its role in managing foodborne illnesses like those triggered by Campylobacter jejuni.

7.8

Improved immunity

Most Useful Review

Powder Vitamin C was effective for me. As it's powdered, it has less oxidation concern. I felt less fatigue, and my immunity improved, leading to fewer colds. This product is highly recommended, particularly for its benefits in treating food poisoning.

Reflux

Vitamin C aids omeprazole therapy

Antioxidant pre-treatment prevents omeprazole-induced toxicity in an in vitro model of infectious gastritis.

Most Relevant Research

We aimed to understand how Vitamin C could help with the toxicity caused by omeprazole, a common treatment for conditions like gastroesophageal reflux disease (GERD) and gastritis. During our study, we examined gastric cells from rabbits to see how Vitamin C, alongside other antioxidants, could protect these cells from damage caused by omeprazole.

We found that both omeprazole and another thiol-oxidant, monochloramine, significantly reduced cell viability. Interestingly, the toxicity from omeprazole occurred independently from monochloramine. However, we observed that using Vitamin C effectively protected the gastric cells from this injury, maintaining their function without interfering with omeprazole's intended effects.

This suggests that incorporating Vitamin C into treatment plans for people using proton pump inhibitors (PPIs) like omeprazole could be beneficial. Ultimately, our research highlights the potential of using antioxidants to mitigate the adverse effects often associated with medication for reflux and related conditions.

7.5

Health improvement noted

Most Useful Review

We have been using this for years, and it has greatly benefitted our health! If we feel a cold coming on, we increase our intake and our colds tend to be much shorter. Regular use helps with my acid reflux at night, rosacea, and even fine lines around my eyes vanished after three months. It also keeps constipation away, which is a huge plus!

Rosacea

Rosacea treatment with vitamin C

[Angioprotectors in the treatment of rosacea].

Most Relevant Research

We explored the effectiveness of Rutin Forte, a treatment that includes long-acting vitamin C along with zinc and selenium, in managing rosacea, particularly in its erythematous stage. Our study included 30 patients—20 women and 10 men, aged 25 to 50—who were divided into two groups. One group received standard treatments like antibiotics and topical therapies, while the other group received the same treatments along with Rutin Forte for 2 to 3 months.

Over a 12-month observation period, we observed significant improvements in the group that received Rutin Forte. This group showed a notable reduction in erythema, the redness associated with rosacea, and intriguingly, there were no relapses of the condition. Conversely, the standard treatment group experienced recurrences of rosacea by the third month of follow-up, and their reduction in erythema was less pronounced.

This indicates that Rutin Forte, likely due to the vitamin C it contains, might play a beneficial role in treating and preventing rosacea symptoms, particularly in stubborn cases. Overall, our findings suggest that incorporating vitamin C into rosacea treatment can be quite effective.

7.5

Effective relief

Most Useful Review

Very helpful to our health. We've been using this for years! It aids us, particularly when we feel a cold coming on, shortening its duration to just a day or two. I also find it beneficial for acid reflux at night, managing rosacea on my face, and reducing fine lines around my eyes after three months of regular use. It helps prevent constipation too.

Acne

Vitamin C shows effectiveness for acne

Based on 16 Researches

Sodium L-ascorbyl-2-phosphate 5% lotion for the treatment of acne vulgaris: a randomized, double-blind, controlled trial.

Most Relevant Research

In our recent study, we set out to explore the effectiveness of a 5% sodium L-ascorbyl-2-phosphate lotion, a stable form of vitamin C, for treating acne. We conducted a double-blind, controlled trial with 50 participants over 12 weeks, where half used the vitamin C lotion and the other half received a placebo.

Our findings revealed significant improvements in acne symptoms for those using the vitamin C lotion compared to the placebo group. We measured outcomes through various assessments, including a global evaluation by investigators and self-reported assessments by the subjects, along with lesion counts.

The results showed that the vitamin C lotion was not only effective but also well-tolerated, with side effects similar to those seen with the placebo. This adds a promising tool to the options available for acne treatment, suggesting that vitamin C might play a valuable role in skincare regimens aimed at combating acne.

Overall, our study supports the idea that vitamin C, in the form of sodium L-ascorbyl-2-phosphate, can help reduce acne, making it a noteworthy addition to acne treatment strategies.

9.5

Effective acne treatment

Most Useful Review

I purchased this vitamin C for acne control, and it has worked wonders! After washing my face with water mixed with the powder, I noticed a significant reduction in acne, and my skin's texture improved. I also drink it, and this is the first supplement I've used that has shown such effective results—I'm keen to continue using it.

Dizziness

Ascorbic Acid and Dizziness Study

Change of extracellular ascorbic acid in the brain cortex following ice water vestibular stimulation: an on-line electrochemical detection coupled with in vivo microdialysis sampling.

Most Relevant Research

We explored how ice water vestibular stimulation affects ascorbic acid (AA) levels in the brain, particularly in relation to dizziness. Using a method called in vivo microdialysis coupled with electrochemical detection, we monitored changes in extracellular AA in the primary somatosensory area of guinea pigs. Our study included 16 guinea pigs divided into three groups: one group received ice water stimulation, while the other two were exposed to warm water and ice water without vestibular input.

The results revealed that the concentration of extracellular AA increased in the brain following the ice water stimulation. This finding suggests that there may be neurochemical responses associated with AA that play a role in managing conditions like vertigo. However, while the study shows an intriguing relationship between AA levels and vestibular stimulation, it does not establish a direct link between vitamin C's effectiveness in treating dizziness specifically.

Overall, the insights gained from this research could help pave the way for further investigations into the role of vitamin C in vertigo-related treatments, adding a layer of understanding to its neurochemical functions.

6.5

Dizziness alleviated

Most Useful Review

Really, really. However, there are some vitamin effects. The dizziness has disappeared, in any case.

Chronic Fatigue Syndrome

Vitamin C aids immune function

The clinical course of interstitial pneumonia alias chronic fatigue syndrome under the control of megadose vitamin C infusion system with dehydroepiandrosterone-cortisol annex.

Most Relevant Research

We examined how a combination of megadose vitamin C infusions and other treatments might help manage chronic fatigue syndrome, particularly in the context of interstitial pneumonia. Our findings were based on nearly a decade of treating patients, allowing us to gather valuable insights.

We observed that the long-term use of this treatment system significantly reduced the risk of pneumonia recurrence. It also appeared to help prevent the emergence of certain cancers in older patients suffering from interstitial pneumonia. Surprisingly, we found a link between interstitial pneumonia and an increased risk of depression, likely driven by prolonged glucocorticoid use.

While some patients showed promise under this treatment, those battling both interstitial pneumonia and depression responded less favorably. We suggested that increasing the amount of dehydroepiandrosterone in the treatment could be beneficial. Throughout our experience, we noted that the characteristics of chronic fatigue syndrome align closely with those of interstitial pneumonia, arguing against the notion that they should be viewed as separate conditions.

Overall, our approach not only alleviated inflammation but did not suppress the fibrotic processes in the long run. We made modifications to the treatment to lower the risks of vascular complications. The main strength of our treatment lies in creating a hormonal environment that helps tackle immune deficiencies using vitamin C, which faces lower resistance in the body compared to steroid treatments.

9.5

Reduced fatigue

Most Useful Review

It should be in every home. A lack of Vitamin C leads to issues like bleeding gums, tooth loss, frequent colds, and chronic fatigue syndrome. The daily dose of Vitamin C is 100 mg, which is safe even in larger amounts. The powder has a tart taste, but I've grown to like it. For a toned appearance, I recommend taking Vitamin C along with collagen regularly. This helps in reducing the frequency of illnesses in winter. Make sure to choose quality products without unnecessary additives.

Irritable Bowel Syndrome

Significant improvement

Most Useful Review

Absolutely brilliant! I've been taking this product as opposed to vitamin C tablets, and I've noticed my skin's health improve alongside my bowel activity. After a short time, I notice a marked difference compared to tablets. Very satisfying and highly recommended for managing irritable bowel syndrome!

Migraine

Vitamin C potentially reduces migraines

Association between dietary vitamin C intake and migraine in adults: A cross-sectional study of the National Health and Nutrition Examination Survey.

Most Relevant Research

We explored the connection between dietary vitamin C and migraines using data from the National Health and Nutrition Examination Survey (NHANES) that covered several years from 1999 to 2004. In our analysis, we found that 4101 participants reported their migraine experiences, with over 17% indicating they had faced them recently. Using a detailed dietary recall system to assess vitamin C intake, we conducted various statistical analyses to understand the potential effects of vitamin C on migraine occurrence.

What we discovered was quite intriguing: higher dietary vitamin C intake seemed to be associated with a lower likelihood of experiencing migraines. Specifically, our results showed that those in the highest intake category had a significantly reduced risk of migraines compared to those with the lowest intake. The odds ratio indicated that for every increase in vitamin C intake, the likelihood of migraines decreased.

This linear relationship suggests that incorporating more vitamin C-rich foods into our diets could be beneficial for individuals prone to migraines. Our findings indicate that vitamin C may serve as a useful dietary consideration for managing migraine severity and frequency. Overall, these insights could pave the way for further research and highlight the importance of nutrition in migraine management.

4.8

Headaches experienced

Most Useful Review

There can be side effects when overdosing on vitamin C, which I have noticed, especially with mega doses. Initially, I faced significant headaches and migraines, particularly at the back of my head. After reassessing my intake, I now drink only a small amount of water with the vitamin. It's affordable and good value for money but be cautious of the potential side effects, such as heartburn and headaches.

Nausea

Vitamin C ineffective against nausea

Very Likely Ineffective

The Role of hCG and Histamine in Emesis Gravidarum and Use of a Chewing Gum Containing Vitamin C as a Treatment Option: A Double-Blinded, Randomized, Controlled Trial.

Most Relevant Research

We explored the effects of vitamin C as a treatment for nausea and vomiting in pregnancy, also known as emesis gravidarum. Our study involved 111 participants, who were given either vitamin C-containing chewing gum, a placebo, or no treatment at all. We monitored them over two follow-up visits in early pregnancy to assess their symptoms.

While we measured various factors that could influence nausea—including hormone levels like hCG and DAO—our findings showed that the chewing gum did not effectively reduce nausea symptoms compared to the placebo or no treatment. Specifically, the vitamin C gum was not associated with any significant alleviation of nausea or vomiting.

Interestingly, we found that elevated levels of hCG were linked to increased nausea severity. In contrast, higher levels of DAO appeared to have a protective effect against symptoms. Additionally, elevated thyroxine and pyridoxine levels correlated with worsened nausea.

Overall, while vitamin C is often highlighted for its health benefits, our results suggest it does not play a significant role in treating nausea during pregnancy. This study highlights the complexities behind nausea in pregnancy, indicating that further research is necessary to uncover effective treatment options.

9.5

Nausea relief experienced

Most Useful Review

I purchased this product to make liposomal Vitamin C, as it can enhance bioavailability. After preparing it, I took a tablespoon and felt significantly better within two hours. The persistent nausea I had suffered from after a bout with the flu vanished, and my mood improved notably. I will be encouraging others to try this, as it appears to be effective for alleviating nausea. Just be cautious about exposing your teeth to acidic Vitamin C, as it may harm your enamel.

Headache

Vitamin C intake reduces migraines

USERS' SCORE

Good

Based on 7 Reviews

Association between dietary vitamin C intake and migraine in adults: A cross-sectional study of the National Health and Nutrition Examination Survey.

Most Relevant Research

We aimed to understand how dietary vitamin C affects migraines by analyzing data from the National Health and Nutrition Examination Survey, conducted from 1999 to 2004. In this survey, we identified adults who reported experiencing severe headaches or migraines over the past three months.

Our findings were quite revealing. Out of 4,101 participants, 702 individuals reported having a migraine, which represents about 17% of the group. We discovered an interesting trend: higher dietary vitamin C intake seemed to correlate with a lower likelihood of experiencing migraines. Specifically, participants with the highest vitamin C intake had a 36% reduced odds of suffering from migraines compared to those with the lowest intake.

We employed various statistical methods to confirm our results, including logistic regression and restricted cubic spline regression, which showed a clear linear relationship between vitamin C intake and the frequency of migraines.

Overall, this study suggests that increasing our dietary vitamin C might help minimize migraines, which is promising news for those who suffer from these intense headaches. However, as with all studies, further research is necessary to solidify these findings and fully understand the relationship between vitamin C and headache relief.

9.5

Less headache

Most Useful Review

The sour taste of the vitamin C is delightful and especially necessary during colds in autumn. I dilute a teaspoon in 250 ml of water, which I divide into portions throughout the day for better absorption. It supports my immunity, reduces headaches, and gives me more energy.

Ulcer

Vitamin C reduces gastric ulcers

Vitamin C modulates adrenaline-augmented gastric injury via cardiac troponin/creatine kinase pathway in Wistar rats.

Most Relevant Research

We observed the potential benefits of vitamin C in managing gastric ulcers under conditions of myocardial injury, which was induced using adrenaline in our study. Thirty Wistar rats were carefully divided into five groups, ensuring a control group for comparison.

The rats that received adrenaline alone showed increased gastric secretions and elevated markers related to heart injury. However, those pre-treated with vitamin C experienced a notable reduction in ulcer severity and excessive gastric secretions.

Interestingly, when we administered vitamin C before the adrenaline exposure, we found that it significantly decreased both the volume of gastric juice and total acidity, while also enhancing some protective factors. In essence, our research indicates that vitamin C may play a protective role in gastric health, particularly amid the stressful conditions created by adrenaline.

7.5

Cost-effective megadoses

Most Useful Review

This NOW Vitamin C is cost-effective and suitable for megadoses of over 10g daily. I've been doing megadoses for about 10 years, and it's crucial for managing my gastric and duodenal ulcers.

Chest Pain

Vitamin C improves coronary response

Based on 13 Researches

Effect of ascorbic acid on endothelial dysfunction of epicardial coronary arteries in chronic smokers assessed by cold pressor testing.

Most Relevant Research

We explored the effects of vitamin C on chest pain in chronic smokers experiencing endothelial dysfunction. In our study, 31 patients, who were undergoing diagnostic catheterization without significant coronary artery issues, participated in a controlled trial. They were given either an IV infusion of 3 grams of ascorbic acid (vitamin C) or a placebo saline solution before undergoing a cold pressor test to assess their coronary artery response.

The results were telling. Smokers typically showed a decrease in luminal area—an indicator of blood flow—during the cold pressor test. However, after infusing vitamin C, this response shifted positively, demonstrating improved blood flow through a vasodilation effect. On the other hand, those who received the placebo did not experience significant changes.

This means that for chronic smokers, acute administration of vitamin C appears to enhance the function of the endothelium, which is vital for proper blood vessel health and managing chest pain. Ultimately, we observed that vitamin C may help prevent the inactivation of nitric oxide, a compound that supports healthy blood flow, and this effect could be crucial for managing cardiovascular health in smokers.

8.8

Reduced joint pain

Most Useful Review

Joint pain and stiffness have significantly decreased for both my dog and me. My 60-pound Border Collie is much better; his joint stiffness and pain have lessened noticeably. I continue using this Vitamin C form as it works well for me, although my dog prefers sodium ascorbate due to taste. Just a note, this is a non-GMO product.

Hives

I've been purchasing this powder frequently as it's more cost-effective than capsules. Although the spoon isn't included, it's worth it. Vitamin C has been very helpful, not just for colds but also for severe hives and itching. When the symptoms peaked, I took 1000mg every 10 minutes, and it alleviated the discomfort within an hour. This is an essential supplement to have at home.

Blood Clot

Vitamin C enhances blood clotting

Based on 6 Researches

Ascorbic acid improves thrombotic function of platelets during living donor liver transplantation by modulating the function of the E3 ubiquitin ligases c-Cbl and Cbl-b.

Most Relevant Research

We sought to understand how ascorbic acid, commonly known as vitamin C, impacts blood clotting during living donor liver transplantation (LDLT). In our study, we analyzed blood samples from 21 recipients before and after their surgeries.

We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.

Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.

This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.

Health concerns noted

Most Useful Review

Not good - be careful. I was advised to take this vitamin C in high doses. Initially, I felt good, but I developed symptoms resembling a urinary infection, along with pain and even blood. My friend had similar issues like back pain and pressure behind the eyes. We both stopped taking it, and the problems went away. I'm now trying a different brand from Holland that is acid-free, as perhaps the acid was too much for me. I’ve never had issues with this other brand.

Urinary Tract Infection

Vitamin C shows promise for UTIs

Based on 10 Researches

Network analysis, and human and animal studies disclose the anticystitis glandularis effects of vitamin C.

Most Relevant Research

We explored how vitamin C (VC) might help in treating cystitis glandularis (CG), a condition often linked with urinary tract infections (UTIs). Utilizing network pharmacology, we identified potential therapeutic targets of VC and the biological pathways it may influence to alleviate CG symptoms.

Our study involved both bioinformatic analyses and real-world observations, including human and animal studies. Through these methodologies, we pinpointed key biomarkers associated with CG, such as TNF-α, IL6, and c-Jun, which were notably elevated in patient samples.

Encouragingly, when VC was administered to mice with CG, we observed a significant decrease in these inflammatory markers in both blood and bladder samples. This suggests that VC could play a beneficial role in reducing symptoms associated with UTIs by targeting these key molecular pathways.

9.5

Relief from pain

Most Useful Review

This versatile powdered ascorbic acid was beneficial for my kidney stones; I found it more effective than herbal remedies. I took half a teaspoon dissolved in 16oz of water twice daily and experienced no pain. This product alters the urine's pH to help with the stones, and it's pure vitamin C without any fillers. It's economical too. My father, who suffers from chronic kidney infections, also found it helpful.

Yeast Infection

Likely Very Effective

Vitamin C enhances antifungal treatment

Ascorbic Acid Enhances the Inhibitory Effect of Theasaponins against .

Most Relevant Research

We explored the potential of vitamin C in combination with theasaponins to combat yeast infections, specifically focusing on their collective effectiveness. In this study, we used a method designed to test various concentrations of vitamin C along with theasaponins, aiming to assess how these components work together against the yeast that causes infections.

The results were telling; vitamin C significantly enhanced the ability of theasaponins to target both the yeast's active cells and its biofilm formations, which are crucial for survival. With added vitamin C, we noted a remarkable decrease in the minimum amount of theasaponins needed to inhibit growth, indicating that the combination is more potent together than alone.

Interestingly, this collaboration seemed to struggle against the yeast's communication and defense mechanisms, creating more oxidative stress and damage to cellular structures. By analyzing gene activity, we observed that the combination of vitamin C and theasaponins disrupted essential metabolic pathways, suggesting a powerful effect against the yeast.

Overall, our findings support the idea that vitamin C can play a critical role in enhancing treatments for yeast infections, showcasing its potential as part of an effective topical antifungal approach.

Avoid due to issues

Most Useful Review

I was advised to take this vitamin C in high doses. Initially, I felt good, but then I experienced symptoms resembling a yeast infection, with frequent urination, pain, and even blood. A friend who also started taking it had back pain and pressure behind her eyes. We both decided to stop after recognising these issues. I'm concerned about how it affected my health, but those problems faded after I discontinued use. Now, I'm trying a different acid-free brand from Holland, which has worked for me before.

Gastritis

Vitamin C lessens oxidative stress

Based on 12 Researches

Protective effect of vitamin C on oxidative stress: a randomized controlled trial.

Most Relevant Research

We aimed to discover how vitamin C supplementation affects oxidative stress in individuals diagnosed with chronic gastritis. In this study, we looked at 244 Japanese patients suffering from atrophic gastritis. They were randomly assigned to receive either 50 mg or 500 mg of vitamin C every day for five years.

After analyzing the results, we found notable differences between the two groups. The high-dose group experienced a significant decrease in reactive oxygen species (ROS), suggesting that vitamin C may help reduce oxidative stress associated with chronic gastritis. In contrast, the low-dose group reported an increase in ROS levels. These findings prompt further interest in how vitamin C can protect against oxidative stress in similar conditions.

Overall, our study supports the idea that higher doses of vitamin C could have a beneficial effect on oxidative stress, particularly in those dealing with gastritis. This insight opens avenues for considering vitamin C as a potential supportive treatment for managing oxidative stress-related issues in digestive health.

9.5

Perfect for gastritis

Most Useful Review

I can't count how many I’ve had while doing megadosing. With gastritis, I took it right after meals. It’s perfect for megadosing and effective. When weary or unwell, I’d take an extra tablespoon, and it always helped. Highly recommended!

Feasibility study for a fully decentralized clinical trial in participants with functional constipation symptoms.

Most Relevant Research

We conducted a fully decentralized clinical trial to explore the effects of vitamin C on constipation symptoms. Participants who experienced functional constipation were randomly assigned to receive either Lactobacillus with vitamin C or vitamin C alone over a two-week treatment period. The study allowed us to gather data remotely, which is quite innovative and accessible.

Looking specifically at the results from the group that received vitamin C, we observed that while there was an increase in the frequency of bowel movements compared to the control group, the isolated effect of vitamin C itself wasn't entirely clear. The combination treatment appeared to improve bowel regularity, but it was difficult to determine how much vitamin C contributed independently to these results.

Additionally, we found that about 67% of participants were diligent in tracking their bowel diary entries, which helped ensure the reliability of our findings to an extent. Yet, a significant portion of the records were not kept as scheduled, highlighting potential hurdles in data collection for decentralized trials.

Overall, our observations suggest that while vitamin C, especially when paired with Lactobacillus, may provide some benefits for those struggling with constipation, we should exercise caution before attributing all improvements solely to vitamin C.

9.5

Eased constipation

Most Useful Review

This product is fantastic! I consumed it as suggested, and it genuinely relieved my constipation. I noticed a brightening effect on my skin as well. Despite initial concerns about bowel movements, this product has worked wonders for me, and I will definitely repurchase it.

Back Pain

Vitamin C's limited impact on pain

Based on 4 Researches

The Efficacy of Vitamin C on Postoperative Outcomes after Posterior Lumbar Interbody Fusion: A Randomized, Placebo-Controlled Trial.

Most Relevant Research

We conducted a year-long study to investigate the effects of vitamin C on postoperative pain and recovery after a specific type of spine surgery known as posterior lumbar interbody fusion (PLIF). In this randomized, placebo-controlled trial, we worked with 123 patients, dividing them into two groups: one receiving vitamin C and the other a placebo.

Our main focus was to see how vitamin C influenced lower back pain measured by a visual analogue scale. While we found that there was no significant difference in pain levels at the one-year mark between the two groups, there was a silver lining. We observed that vitamin C appeared to enhance functional improvement, especially within the first three months after surgery.

So, while vitamin C didn’t seem to directly reduce pain intensity after surgery, it could play a role in supporting early recovery and everyday function. This finding may encourage further exploration into vitamin C's potential benefits in postoperative care for patients undergoing spine surgeries.

9.5

Effective for back pain

Most Useful Review

Great for everyday use, especially during colds and flu! I gave this to my mum when she started feeling ill. Within two days of taking these crystals, she was back on her feet, avoiding doctor visits and infections. Impressive!

Diarrhea

Vitamin C improves diarrheic calf health

Does vitamin C supplementation in milk improve growth and health of diarrheic calves?

Most Relevant Research

We investigated how adding vitamin C to milk influences the growth and health of young calves, particularly those experiencing diarrhea. The study involved 48 Holstein calves, which were sorted into two groups based on their health status: healthy calves and those with diarrhea. Each calf was fed the same amount of pasteurized milk and monitored until they reached 74 days of age.

Calves that received vitamin C showed an impressive increase in weight by weaning—74.3 kg compared to 72.2 kg for those without vitamin C. Additionally, calves treated with vitamin C demonstrated improved blood antioxidant levels, suggesting better overall health. Notably, calves suffering from diarrhea benefitted significantly from the vitamin C, needing fewer days of medication for treatment compared to those who did not receive the supplement.

The research highlights that vitamin C can play a critical role in supporting the health of calves during episodes of diarrhea. This is especially relevant for those that faced even mild cases early in life, as they seemed to gain the most benefits from the supplementation. Overall, it appears that vitamin C can positively impact both growth and health in calves suffering from diarrhea.

8.8

Essential vitamin intake

Most Useful Review

I've been using vitamin C megadoses for ten years. As it's made in England, I trust its quality. I've tried various brands, but this offers the best cost performance. While the basic effect is 10g, I started with 3g after meals, increasing as tolerated. I find my body needs it, especially when I feel unwell. If taken correctly, there are no issues, including diarrhea.

Kidney Stones