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Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₆ (as Pyridoxal 5-Phosphate)
2.5 mg
147%
Folate (800 mcg as 6S)-5MTHF-Methyltetrahydrofolate Glucosamine Salt)
1,360 mcg DFE‡
340%
Vitamin B12 (as Methylcobalamin)
5,000 mcg
208,330%
The product is found useful for the following medical conditions
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.7
USERS' SCORE
Good
Based on 13 Reviews
8.8
9
Pernicious anemia treatment effectiveness
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
Most Relevant Research
We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
9.5
Normal homocysteine levels
Most Useful Review
Reduced my homocysteine from 12 to 5.5. I'm very pleased as it's now perfect! I took these vitamins after a recommendation, and the results were remarkable. My mother is now trying them, as she also suffers from high homocysteine. I hope for her positive results too!
Blood Clot details
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.9
USERS' SCORE
Good
Based on 4 Reviews
8.8
9
Folic acid impacts blood clotting
Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential.
Most Relevant Research
We investigated how folic acid affects blood clotting, particularly when exposed to carbon black (CB), a common industrial substance. In our study with adult C57BL/6 mice, we found that prolonged exposure to CB led to increased blood clotting potential due to changes in the spleen, where extra blood cell production occurs.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
9.5
Preventing blood clots
Most Useful Review
My husband takes this supplement an hour after breakfast to reduce homocysteine levels. It combines active folate and vitamin B12 in one pill. The sublingual form is ideal for B vitamins, as excess homocysteine can lead to blood clots. Therefore, we keep a close eye on it and take steps to prevent any serious issues like strokes or heart attacks.
Cardiovascular Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.8
USERS' SCORE
Good
Based on 8 Reviews
8.7
9
Vitamin B6 shows blood pressure benefits
Pyridoxal-5'-phosphate: A cost-effective treatment candidate for hypertensive patients?
Most Relevant Research
We investigated the potential of vitamin B6, in the form of pyridoxal-5'-phosphate (PLP), to influence blood pressure, particularly in the context of hypertension. Our focus was on how PLP modifies angiotensin II, a peptide that plays a critical role in blood vessel constriction, transforming it into a different form known as pyruvamide-Ang II (Ang P).
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
9.5
Improved health
Most Useful Review
I managed to lower my elevated homocysteine levels, associated with cardiovascular disease. It's vital to monitor this, as it can lead to serious conditions at a young age. This supplement has transformed my life, eliminating dizziness and weakness. Everyone should get tested annually for homocysteine levels. Best wishes for good health!
Heart Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 25 Researches
8
USERS' SCORE
Good
Based on 8 Reviews
8.7
9
Folic acid reduces CHD risk
Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population.
Most Relevant Research
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
9.5
Life improvement
Most Useful Review
Good day! I've successfully lowered my homocysteine levels with this supplement. Elevated homocysteine is linked to heart disease and other health issues. After use, dizziness, weakness, and shortness of breath have disappeared. I highly recommend monitoring homocysteine levels annually for better health outcomes!
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 7 Reviews
8.7
9
Vitamin B6 reduces cholesterol levels
Antihyperlipidemic and Hepatoprotective Properties of Vitamin B6 Supplementation in Rats with High-Fat Diet-Induced Hyperlipidemia.
Most Relevant Research
We aimed to understand how Vitamin B6 influences high cholesterol levels, particularly through its effects on lipid metabolism in rats induced by a high-fat diet. To set the stage for our exploration, we used male Sprague-Dawley rats and placed them on this fat-rich diet for two weeks to establish a hyperlipidemia model.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
9.5
Successful pregnancy
Most Useful Review
Guaranteed to lower homocysteine! It helped facilitate my long-awaited second pregnancy. After one month, my homocysteine levels decreased, leading to pregnancy. Previously, I took regular folic acid. Now, I always keep it in my first aid kit and buy it for my parents, as high cholesterol can cause vascular issues. It comes in chewable tablets with a pleasant cherry flavour.
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.3
USERS' SCORE
Good
Based on 4 Reviews
8.7
9
Vitamin B6 treatment alleviates anxiety
Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring.
Most Relevant Research
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
10
No more anxiety
Most Useful Review
No more insomnia, anxiety, or depression! I have homozygous MTHFR C677T, along with a history of anxiety, depression, and insomnia. After trying numerous medicines and therapies without success, I reluctantly tried methylated B vitamins. Remarkably, within a week, I began sleeping well, and both my anxiety and depressive feelings dissipated. This has been a life-changing treatment for me!
Liver Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.3
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Folate treatment aids liver fat reduction
DNA hypermethylation-induced suppression of ALKBH5 is required for folic acid to alleviate hepatic lipid deposition by enhancing autophagy in an ATG12-dependent manner.
Most Relevant Research
We investigated the effects of folic acid treatment on nonalcoholic fatty liver disease (NAFLD), a condition where excess fat builds up in the liver, often linked to obesity and insulin resistance. Our research revealed that giving folic acid to mice on a high-fat diet helped improve their glucose tolerance and insulin sensitivity, alongside reducing unhealthy fat levels in their liver cells.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
8.8
Improved calmness
Most Useful Review
This was recommended by my nutritionist, and since then, my sleep has improved and I've felt calmer. I’m keen to undertake another course to continue addressing my liver disease.
Stroke details
SCIENTIFIC SCORE
Possibly Effective
Based on 36 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Vitamin B12 alleviates stroke effects
Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice.
Most Relevant Research
We investigated how vitamin B12 impacts neuroinflammation and recovery after an ischemic stroke. Our findings revealed that vitamin B12 plays a crucial role in programming microglial cells—immune cells in the brain—helping them divide and activate effectively, which is vital during the healing process. This treatment appeared to improve the metabolism of these cells as well, promoting better functionality and reduced brain injury after a stroke.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
9.3
Effective B vitamins
Most Useful Review
This excellent formulation contains three crucial B vitamins. It dissolves under the tongue for quick absorption, aiding in the prevention of heart disease and stroke by lowering homocysteine levels.
Nausea details
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.7
4
Vitamin B6 risks in pregnancy
The potential hazards of high doses of vitamin B6 in treating nausea and vomiting in pregnancy: A systematic review.
Most Relevant Research
We investigated the use of vitamin B6 as a common treatment for nausea and vomiting during pregnancy. There has been an ongoing discussion about how effective high doses of this vitamin actually are, and we wanted to shed light on this issue.
Through a systematic review of literature, we examined various studies, focusing on reports that highlighted the effects of high doses of vitamin B6 on pregnant women experiencing nausea. While we found that many women do turn to vitamin B6 to alleviate their symptoms, particularly during the challenging first trimester, the data also raised serious concerns about potential side effects.
A significant portion of the studies reviewed documented adverse reactions in women taking excessive amounts of vitamin B6. These included neurological symptoms such as burning sensations, tingling, and coordination problems. Alarmingly, we also noted a few cases of miscarriage and intrauterine demise among those studied.
Overall, while vitamin B6 is a widely used treatment for nausea during pregnancy, we must exercise caution. The risks associated with high doses cannot be overlooked, particularly when it comes to the health of both the mother and the developing fetus.
Through a systematic review of literature, we examined various studies, focusing on reports that highlighted the effects of high doses of vitamin B6 on pregnant women experiencing nausea. While we found that many women do turn to vitamin B6 to alleviate their symptoms, particularly during the challenging first trimester, the data also raised serious concerns about potential side effects.
A significant portion of the studies reviewed documented adverse reactions in women taking excessive amounts of vitamin B6. These included neurological symptoms such as burning sensations, tingling, and coordination problems. Alarmingly, we also noted a few cases of miscarriage and intrauterine demise among those studied.
Overall, while vitamin B6 is a widely used treatment for nausea during pregnancy, we must exercise caution. The risks associated with high doses cannot be overlooked, particularly when it comes to the health of both the mother and the developing fetus.
6.8
Nausea from vitamins
Most Useful Review
I’ve been taking single methylated B-vitamins for some time. Due to the MTHFR mutation, I struggle to methylate vitamins, feeling nauseated and somewhat hungover with regular multi-vitamins. Methylated versions may not cause nausea. If they don’t, you may also have this mutation. B vitamins are crucial for neurological health, especially folate for pregnant women. If you can’t process them, you miss out on their benefits. I prefer Jarrow for the consistent quality of their supplements.
