Jarrow Formulas Quercetin 500 mg

Quercetin's role against colorectal cancer

Based on 16 Researches

Structure-activity relationship analysis of mono-methylated quercetins by comprehensive MS/MS analysis and anti-proliferative efficacy in human colorectal cancer cells.

Most Relevant Research

We aimed to understand how quercetin and its derivatives, especially mono-methylated quercetins (MQs), might help in treating colorectal cancer. Using advanced techniques like tandem mass spectrometry, we identified specific structural features of these flavonoids that could enhance their anti-cancer activities.

Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.

We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.

Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.

9.5

Cancer resistance

Most Useful Review

Quercetin is a unique and irreplaceable substance that effectively fights against various cancers, including breast and pancreatic cancer. It enhances vascular tone, combats atherosclerosis, allergies, and regulates blood pressure. Additionally, it helps in reducing inflammation and boosts immune response. However, it is vital to know the correct dosage, as excessive intake may be harmful.

Allergies

Quercetin shows promise in allergies

Likely Very Effective

In-silico exploring pathway and mechanism-based therapeutics for allergic rhinitis: Network pharmacology, molecular docking, ADMET, quantum chemistry and machine learning based QSAR approaches.

Most Relevant Research

We delved into the potential of quercetin as a therapeutic option for treating allergic rhinitis, a common condition affecting roughly 40% of the global population. This study utilized various in-silico approaches, such as network pharmacology and molecular docking, to identify compounds from traditional medicinal plants and assess their effectiveness.

Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.

While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.

Life-changing solution

Most Useful Review

It saved me from my chronic allergies in spring and summer. I suffered from allergies until I was 30 years old when I discovered Quercetin. More people should know about this product, as even doctors often prescribe ineffective medications that only temporarily alleviate symptoms.

VvbZIP22 regulates quercetin synthesis to enhances cold resistance in grape.

Most Relevant Research

We observed that quercetin, a powerful antioxidant, plays a significant role in helping grapes withstand cold temperatures. In our study, we found that grapes exposed to low temperatures accumulate more quercetin, which in turn enhances their cold resistance.

By applying exogenous quercetin, we noted a marked improvement in the grapes' ability to endure low-temperature stress. Our research revealed that a key gene, VvFLS1, responsible for quercetin synthesis is upregulated when grapes experience cold conditions.

We also discovered that VvbZIP22, a protein that binds to the VvFLS1 promoter, is crucial for mediating this process. When we overexpressed VvbZIP22 in grapes, it resulted in higher levels of quercetin and improved cold resistance, further confirming its pivotal role in the plant's adaptation to harsh environments.

Through these findings, we highlighted the importance of quercetin in enhancing grape survival during cold spells, showcasing a vital link between plant biology and climate resilience.

9.5

Breathing better.

Most Useful Review

WHERE HAVE YOU BEEN ALL MY LIFE? I have suffered from perennial rhinitis for as long as I can remember. Always sniffling and feeling blocked, leading to trouble breathing during activities. After struggling with bronchitis from post-nasal drip, and having been advised by my ENT doctor about swollen turbinates, I began taking this product. I’ve only had it for three days, one pill in the morning, and my turbinates have returned to normal size. My breathing is now completely unobstructed. This product is wonderful and appears more effective than similar options!

Cough

It works! Yesterday, I felt awful, wheezing at night and coughing up green mucus. I took my last two capsules along with two NACs and one Zinc. Within three hours, I felt much better. I'm delighted; I was not looking forward to being off work again! This is my second bottle, and I will keep taking it.

Quercetin alleviates gout symptoms

Based on 11 Researches

Quercetin inhibits gout arthritis in mice: induction of an opioid-dependent regulation of inflammasome.

Most Relevant Research

We explored the effects of quercetin, a natural compound, on gout arthritis induced by monosodium urate (MSU) crystals. Our research specifically looked at how quercetin alleviates pain and inflammation associated with gout while examining its interaction with naloxone, a substance known to block opioid receptors.

Mice were treated with quercetin, and we assessed their pain sensitivity from 1 to 24 hours post-MSU injection. Our observations included evaluating the recruitment of white blood cells, levels of inflammatory cytokines, oxidative stress, and activation of certain molecular pathways in the knee joints, all measured at 24 hours after the MSU was introduced.

The results were promising: quercetin effectively reduced MSU-induced pain, inflammation, and related oxidative stress. Notably, the presence of naloxone seemed to negate these benefits, indicating that quercetin's effects are linked to opioid pathways. These findings suggest that quercetin could be a valuable therapeutic option for managing gout symptoms, highlighting its dual role as both an analgesic and anti-inflammatory agent.

8.8

Effective gout management

Most Useful Review

GOUT Remedy with both Bromelain and Quercetin has worked wonderfully for me over the past five years. My gout remains under control. It's important to remember that food is medicine, so I avoid anything harmful to me, particularly foods that trigger gout.

High Cholesterol

Reduces cholesterol risk

Quercetin is an excellent antioxidant. I took it on my doctor's advice. It protects the brain and heart from damage due to insufficient blood supply, especially with high blood pressure. Quercetin lowers the risk of chronic vascular diseases and helps reduce high cholesterol. My cardiologist recommended it for my mother after her heart attack, and she’s advised to take it twice a year.

Leg Cramps

I introduced a friend who used two capsules for leg cramps, and she experienced very positive results.

Liver Disease

Quercetin is an excellent antioxidant. I had my mother take a course upon her doctor's recommendation. This supplement offers numerous benefits, including protecting the brain and heart against damage from insufficient blood supply, especially with high blood pressure. It's known to reduce the risk of chronic vascular conditions and improve their permeability. After her heart attack, a cardiologist advised my mother to take it twice a year.

Bronchitis

Quercetin shows promise for bronchitis

Likely Very Effective

Integrating serum pharmacochemistry, network pharmacology and untargeted metabolomics strategies to reveal the material basis and mechanism of action of Feining keli in the treatment of chronic bronchitis.

Most Relevant Research

We aimed to gather insights into how quercetin, a component of the herbal preparation Feining Keli (FNKL), may influence chronic bronchitis (CB) treatment. In our study, a rat model of CB was created using a combination of nasal drops of lipopolysaccharide (LPS) and smoking exposure. This model allowed us to evaluate the effectiveness of FNKL in a controlled environment, assessing behavioral changes, body mass, and lung health through various examinations.

Our findings indicated that FNKL has positive effects on CB, showing a potential benefit in alleviating symptoms. One crucial element we identified was quercetin-3-galactoside, which appears to play a significant role in FNKL's effectiveness. We discovered that quercetin might help by reducing inflammation and oxidative stress while regulating metabolic activity associated with bronchitis.

However, it’s important to note that while quercetin is active within the FNKL complex, our study does not isolate its effects from other ingredients. This means that while its importance is highlighted, we cannot conclusively determine quercetin’s standalone effectiveness in treating bronchitis.

Improved breathing

Most Useful Review

WHERE HAVE YOU BEEN ALL MY LIFE? I've suffered from perennial rhinitis and have struggled with bronchitis due to post-nasal drip. After taking Nasonex, I sought an alternative and found this product. After three days, my breathing is now completely unobstructed. This Quercetin formula seems more potent than others I've tried. It’s a wonderful product!

Hemorrhoids

I have long struggled with bleeding hemorrhoids and found no relief from expensive prescription treatments. After my husband researched natural alternatives, I started using three products, including Quercetin, which have entirely stopped my bleeding. I've experienced severe bleeding before, and I now rely on all three products for continuous relief.

Chest Pain

The 30-pound small bottle is convenient and effective in relieving my chest pain during menstruation. Highly recommend!

Hyperthyroidism

Effective improvement

Hyperthyroidism, neck swelling, and nodules have been significantly improved.

Lung Cancer

My doctor, a leading oncologist, recommended the Jarrow brand for my treatment for prostate cancer. He stated it is the brand that most accurately reflects its label.

Pneumonia

Improve lung function

The quality is good; my whole family took it during covid. Our Ukrainian scientists noted quercetin's effectiveness in covid pneumonia and inflammation, improving lung function recovery.

Arthritis

Quercetin nanoparticles reduce senescence

Based on 16 Researches

Nanoparticle-delivered quercetin exhibits enhanced efficacy in eliminating iron-overloaded senescent chondrocytes.

Most Relevant Research

We explored the effects of quercetin, a natural compound with potential benefits for treating osteoarthritis (OA), specifically focusing on its ability to target damaged chondrocytes, the cartilage cells that play a crucial role in joint health. In our study, we utilized specialized nanoparticles to increase the effectiveness of quercetin, overcoming its usual limitations related to absorption and bioavailability.

Our research involved subjecting human chondrocytes to conditions that mimic OA. Afterward, we treated them with either free quercetin or our quercetin-loaded nanoparticles (Q-NP). We found that the Q-NP not only allowed for better cellular absorption but also selectively induced apoptosis, or programmed cell death, in senescent chondrocytes. This is significant because eliminating these unhealthy cells could pave the way for healthier joint repair and function.

In addition to promoting cell death in the right cells, Q-NP led to an increase in oxidative stress and reduced key markers of cellular aging. We also noted that the treatment halted the cell cycle in cells that needed to be eliminated. Overall, our findings suggest that enhancing quercetin delivery through nanoparticles holds great promise for improving osteoarthritis outcomes by actively removing harmful senescent cells from joint tissues.

Helpful for knees

Most Useful Review

They are good. I was advised to take them for my arthritis in my knee by my acupuncturist. They do dry you out, so consider the dosage carefully.

Hair Loss

Quercetin may aid hair growth

Based on 4 Researches

Quercetin rescues dihydrotestosterone-treated human dermal papilla cells via SHP2/AKT signaling to suppress autophagy and apoptosis.

Most Relevant Research

We explored the effects of quercetin on hair loss, particularly its ability to counteract damage caused by dihydrotestosterone (DHT). This compound has gained attention for its various health benefits, yet its role in hair follicle health was not fully understood until now.

Our research focused on how quercetin can protect human dermal papilla cells from the harmful effects of DHT. We observed that quercetin not only improves cell function but also influences the proteins involved in the cell cycle. Additionally, it helps reduce oxidative stress and preserves energy within the cells, maintaining their mitochondrial health.

Through network pharmacology analysis, we discovered that quercetin targets a protein called SHP2, which plays a pivotal role in regulating AKT signaling pathways. Excitingly, our findings showed that quercetin even promotes hair growth in mice, further underlining its potential as a natural treatment for hair loss. Overall, these insights suggest that quercetin may serve as a promising candidate for supporting hair regeneration and combating hair loss effectively.

8.8

Reduced inflammation

Most Useful Review

Love, love, love this product! It helped with my oak pollen allergy and improved my leaky gut. My hair loss is also improving, likely due to reduced inflammation!

Hives

I've used Quercetin as an alternative to antihistamines for chronic urticaria for the past two years. On average, I’ve taken two antihistamines daily; however, they can cause fatigue. When unable to tolerate antihistamines, I switched to Quercetin. I found that 1000-1500 mg daily is effective without causing drowsiness. This brand has been the best for me, showing noticeable improvements in my skin.

Nausea

Quercetin effectively reduces nausea

Likely Very Effective

Brain mitochondrial damage attenuation by quercetin and N-acetyl cysteine: peripheral and central antiemetic effects.

Most Relevant Research

We explored how quercetin, a natural antioxidant, affects nausea induced by substances like ipecac and copper sulfate in a controlled study involving chickens. Both quercetin and another antioxidant called N-acetylcysteine (NAC) were tested to see whether they could alleviate emesis (vomiting) and also protect the brain from oxidative damage.

Our findings revealed that quercetin and NAC did, in fact, significantly reduce vomiting compared to the control group. We observed notable improvements in markers of oxidative damage in the brain, such as reduced lipid peroxidation and lower levels of reactive oxygen species and protein carbonyls after administering quercetin and NAC. This suggests that these substances enhance mitochondrial function and boost antioxidant levels within the body.

Interestingly, when we combined quercetin with NAC, the effects were even more pronounced, implying that utilizing both together may offer greater protection against nausea and brain oxidative stress. Overall, this study indicates that quercetin could play a valuable role in managing nausea through both peripheral effects (like reducing vomiting) and central effects (like protecting the brain).

8.8

No nausea experienced

Most Useful Review

The quercetin capsule is not tiny but easy to open. I mixed the powder with warm water. After some cold symptoms, I took it alongside a crushed zinc tablet. Later that day, I realised I had forgotten my cold signs without any nausea—very pleased with this product!

Poison Ivy

Well, I'm using it to prevent poison ivy. During my Annual Training in the woods, where I typically suffer from poison ivy, I only developed one blister, which is remarkable for me. I will gauge its effectiveness further when I go camping at the end of the month.

Blood Clot

After taking three tablets, my condition improved significantly, alleviating my hyperlipidaemia and angina pectoris. I experienced headaches and shoulder stiffness, but overall, my circulation feels better. I recommend it, especially for elderly individuals dealing with blood clot risks.

Cold Sores

Respiratory immunity quercetin has supported me since the epidemic began. I take it a couple of times a week, and daily when the illness is prevalent. It helps in reducing the likelihood of catching cold sores.

Knee Pain

Pain reduction achieved