' 
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Red Yeast Rice (Monascus purpureus)
1,200 mg
†
Coenzyme Q10 (Ubiquinone)
100 mg
†
The product is found useful for the following medical conditions
Allergies
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8.8
8
Co-Q10 aids allergic reaction control
The effect of Co-Q10 on allergic rhinitis and allergic asthma.
Most Relevant Research
We investigated how coenzyme Q10 (Co-Q10) affects allergies, particularly allergic rhinitis and asthma. In our study, we used animal models to mimic these conditions and treated them with Co-Q10, either alone or alongside other compounds like Omega-3 and magnesium sulfate.
We collected and analyzed samples from the lungs, measuring various inflammatory markers such as cytokines and IgE levels, which play critical roles in allergic reactions. The results indicated that Co-Q10 helps promote the activity of a protective protein called Nrf2, which is crucial in defending against allergic responses and inflammation.
By increasing Nrf2 levels, Co-Q10 showed potential in reducing the symptoms associated with allergic conditions, helping to control allergic mediators and inflammatory factors. Overall, we found that Co-Q10 treatment could enhance the body’s resilience to allergens, potentially offering a powerful tool against allergic rhinitis and asthma.
We collected and analyzed samples from the lungs, measuring various inflammatory markers such as cytokines and IgE levels, which play critical roles in allergic reactions. The results indicated that Co-Q10 helps promote the activity of a protective protein called Nrf2, which is crucial in defending against allergic responses and inflammation.
By increasing Nrf2 levels, Co-Q10 showed potential in reducing the symptoms associated with allergic conditions, helping to control allergic mediators and inflammatory factors. Overall, we found that Co-Q10 treatment could enhance the body’s resilience to allergens, potentially offering a powerful tool against allergic rhinitis and asthma.
9.5
No allergies noted
Most Useful Review
Excellent quality product with perfectly chosen ingredients that did not cause any allergies. The large packaging is sufficient for a long time, and the capsules are of average size with a neutral taste. I noticed improvements in my intestinal function and metabolism within a week. My nervous system feels better, and I am less anxious. The effectiveness of this vitamin is undeniable.
Heart Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Good
Based on 39 Reviews
8.7
9
CoQ-10 improves heart failure outcomes
Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis.
Most Relevant Research
We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
9.5
Cholesterol lowering
Most Useful Review
Red yeast rice with CoQ10 is an excellent health supplement. It can reduce cholesterol and triglycerides while enhancing heart function. Studies indicate that consuming 2.4 grams daily can effectively lower cholesterol. However, it’s important to consult a physician if you have liver or kidney issues.
Hypertension
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 5 Reviews
8.7
7
Citicoline and CoQ10 protection study
Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension.
Most Relevant Research
We investigated how a combination of citicoline and coenzyme Q10 (CoQ10) might impact retinal cell health in a mouse model of ocular hypertension (OHT). Using four groups of mice, including those receiving the combination treatment and a control group, we aimed to understand if these substances could protect against the loss of retinal ganglion cells, which is a major concern in glaucoma.
The treatment was started 15 days prior to inducing ocular hypertension with a laser and continued until we examined the mice about a week later. Our findings were promising: the combination of citicoline and CoQ10 led to a temporary reduction in eye pressure shortly after treatment. Furthermore, it significantly prevented the death of specific retinal cells that are vital for vision.
While we were encouraged by these results, especially regarding cell protection, it's important to note that there were no significant impacts on neurons in the visual pathway areas we studied, like the dLGN. Overall, our research suggests that this combination might offer neuroprotective benefits in specific aspects of ocular hypertension, paving the way for further exploration into treatments that go beyond only lowering eye pressure.
The treatment was started 15 days prior to inducing ocular hypertension with a laser and continued until we examined the mice about a week later. Our findings were promising: the combination of citicoline and CoQ10 led to a temporary reduction in eye pressure shortly after treatment. Furthermore, it significantly prevented the death of specific retinal cells that are vital for vision.
While we were encouraged by these results, especially regarding cell protection, it's important to note that there were no significant impacts on neurons in the visual pathway areas we studied, like the dLGN. Overall, our research suggests that this combination might offer neuroprotective benefits in specific aspects of ocular hypertension, paving the way for further exploration into treatments that go beyond only lowering eye pressure.
9.5
No side effects
Most Useful Review
Good purchase. The doctor prescribed this for my hypertension, aiming to gradually replace hypertene with red yeast. This product hasn’t caused any side effects, allergies, or rejections and has met its objective. It’s also free from excipients and offers great value for money.
Migraine
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.7
8
Co-Q10 potentially benefits migraine patients
The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial.
Most Relevant Research
We investigated how Coenzyme Q10 (Co-Q10) affects migraine symptoms in a well-structured clinical trial. Over the course of 12 weeks, 84 women aged 18 to 50 diagnosed with episodic migraines participated in a randomized, double-blind study, where they received either Co-Q10 (400 mg/day) or a placebo.
Upon analyzing the results, we observed some promising outcomes. Participants who took Co-Q10 experienced a significant reduction in malondialdehyde (MDA) levels, an indicator of oxidative stress. Additionally, there was a noteworthy increase in high-density lipoprotein cholesterol (HDL-C) levels, which is beneficial for overall heart health. We also noted a decrease in body fat percentage among those receiving Co-Q10.
However, while some improvements were documented, Co-Q10 did not show a significant effect on total antioxidant capacity or other lipid profile measures like low-density lipoprotein cholesterol and triglycerides. Therefore, while Co-Q10 may hold potential for enhancing certain health aspects in migraine sufferers, its overall impact on migraine management and other related parameters remains mixed.
Upon analyzing the results, we observed some promising outcomes. Participants who took Co-Q10 experienced a significant reduction in malondialdehyde (MDA) levels, an indicator of oxidative stress. Additionally, there was a noteworthy increase in high-density lipoprotein cholesterol (HDL-C) levels, which is beneficial for overall heart health. We also noted a decrease in body fat percentage among those receiving Co-Q10.
However, while some improvements were documented, Co-Q10 did not show a significant effect on total antioxidant capacity or other lipid profile measures like low-density lipoprotein cholesterol and triglycerides. Therefore, while Co-Q10 may hold potential for enhancing certain health aspects in migraine sufferers, its overall impact on migraine management and other related parameters remains mixed.
9.5
Migraine relief
Most Useful Review
Hereditary high cholesterol was recommended by a friend to be treated with red yeast rice, and after taking two bottles, my migraine has disappeared. ❤️
Stroke
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 4 Reviews
8.7
8
CoQ10 aids stroke recovery
Dietary intake of coenzyme Q10 reduces oxidative stress in patients with acute ischemic stroke: a double-blind, randomized placebo-controlled study.
Most Relevant Research
We investigated the potential benefits of coenzyme Q10 (CoQ10) supplementation in patients recovering from acute ischemic stroke. In this double-blind, randomized placebo-controlled study, fifty hospitalized patients were divided into two groups; one received 600 mg of CoQ10 daily for 30 days, while the other received a placebo starting 24 hours post-stroke.
Our findings revealed notable improvements among those taking CoQ10. The group supplemented with CoQ10 showed significant reductions in harmful substances linked to oxidative stress, such as malondialdehyde (MDA) and inflammatory interleukin-6 (IL-6). Additionally, we observed increases in beneficial antioxidants, including superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF), suggesting that CoQ10 may aid in neuroprotection and recovery after a stroke.
While some biomarkers did not show significant change, the overall results suggest that CoQ10 could be a valuable addition to rehabilitation programs for stroke patients, potentially improving recovery outcomes.
Our findings revealed notable improvements among those taking CoQ10. The group supplemented with CoQ10 showed significant reductions in harmful substances linked to oxidative stress, such as malondialdehyde (MDA) and inflammatory interleukin-6 (IL-6). Additionally, we observed increases in beneficial antioxidants, including superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF), suggesting that CoQ10 may aid in neuroprotection and recovery after a stroke.
While some biomarkers did not show significant change, the overall results suggest that CoQ10 could be a valuable addition to rehabilitation programs for stroke patients, potentially improving recovery outcomes.
9.5
Effective remedy
Most Useful Review
An irreplaceable remedy for high cholesterol that has helped me after a stroke.
Alzheimer
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Good
Based on 1 Review
8.6
8
Ubiquinol may combat Alzheimer's effects
Spatial and Temporal Protein Modules Signatures Associated with Alzheimer Disease in 3xTg-AD Mice Are Restored by Early Ubiquinol Supplementation.
Most Relevant Research
We explored the effects of ubiquinol, a form of coenzyme Q10, on Alzheimer's disease through a model using 3xTG-AD mice. Our research aimed to understand how disrupted protein modules in the brain correlate with the progression of Alzheimer's, particularly in terms of oxidative stress and protein regulation.
By employing advanced techniques like MALDI-MSI and functional bioinformatics, we examined how these protein modules are altered based on the age of the mice. We found significant deregulation in specific protein modules related to oxidative stress and metabolism, especially in the hippocampus of younger mice (6 months old) and in the cortical regions of older mice (12 months old). This suggests that early intervention might be crucial to address these changes.
Remarkably, we observed that introducing ubiquinol at an early stage could help restore these protein modules back to a healthier state. This is exciting because it means dietary adjustments, particularly an increase in ubiquinol, could be beneficial in preventing the progression of Alzheimer’s symptoms, both in mice and potentially in humans.
Our findings not only highlight the impact of early dietary intervention but also reinforce the significance of exploring coenzyme Q10 and its benefits for brain health as we age. We believe these insights could pave the way for promising new strategies to combat Alzheimer's disease.
By employing advanced techniques like MALDI-MSI and functional bioinformatics, we examined how these protein modules are altered based on the age of the mice. We found significant deregulation in specific protein modules related to oxidative stress and metabolism, especially in the hippocampus of younger mice (6 months old) and in the cortical regions of older mice (12 months old). This suggests that early intervention might be crucial to address these changes.
Remarkably, we observed that introducing ubiquinol at an early stage could help restore these protein modules back to a healthier state. This is exciting because it means dietary adjustments, particularly an increase in ubiquinol, could be beneficial in preventing the progression of Alzheimer’s symptoms, both in mice and potentially in humans.
Our findings not only highlight the impact of early dietary intervention but also reinforce the significance of exploring coenzyme Q10 and its benefits for brain health as we age. We believe these insights could pave the way for promising new strategies to combat Alzheimer's disease.
9.5
Cholesterol reduction
Most Useful Review
Very good composition! Taking drugs based on red yeast rice reduces the risk of atherosclerosis, hypertension, and coronary heart disease. It also normalises cholesterol levels and controls fat metabolism in the body, thus lowering the risk of Alzheimer's disease. I highly recommend it!
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.7
USERS' SCORE
Good
Based on 3 Reviews
8.6
8
Ubiquinol-10 benefits chronic fatigue syndrome
Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome.
Most Relevant Research
We embarked on a study to investigate the impact of ubiquinol-10—an active form of coenzyme Q10—on patients suffering from chronic fatigue syndrome (CFS). Our research comprised two parts: an open-label study involving 20 patients and a randomized, double-blind, placebo-controlled trial with 43 participants.
In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.
Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.
Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.
In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.
Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.
Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.
9.5
LDL reduction
Most Useful Review
Having struggled with cholesterol levels for years due to chronic hepatitis B, I sought natural alternatives after my GP suggested diet and exercise. After trying various supplements without success, I began taking red yeast rice five weeks ago. To my delight, my LDL dropped by over 35%, achieving a ratio change from 4.3:1 to 3.2:1. So far, I’ve experienced no side effects, and I hope the quality remains high.
Heart Attack
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 14 Reviews
8.6
9
Coenzyme Q10 aids heart recovery
Coenzyme Q10 Modulates Remodeling Possibly by Decreasing Angiotensin-Converting Enzyme in Patients with Acute Coronary Syndrome.
Most Relevant Research
We investigated how coenzyme Q10 might help with heart function after a heart attack, particularly focusing on its role in heart remodeling. In a well-structured study involving 55 patients with left ventricular dysfunction following an acute myocardial infarction, we compared the effects of coenzyme Q10 to a placebo over a 24-week period.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
8.3
Lowering cholesterol
Most Useful Review
Red yeast rice is often used by those unable to tolerate statins. It may also lower coenzyme Q10 levels, so supplementation with ubiquinol is advisable. I took red yeast rice for my cholesterol, which was almost three times higher than normal. After two months, my cholesterol levels dropped significantly, although the results might not be immediate. I feel hopeful and will continue with this supplement, planning to order more. Retesting will provide more insight into its effectiveness in preventing heart attack.
Liver Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
USERS' SCORE
Good
Based on 18 Reviews
8.6
9
Coenzyme Q10 improves liver health
Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial.
Most Relevant Research
We conducted a study to explore the effects of high-dose coenzyme Q10 supplementation on patients suffering from liver disease related to metabolic dysfunction, known as Metabolic-dysfunction Associated Steatotic Liver Disease (MASLD). In a well-structured double-blind, placebo-controlled trial with sixty participants, half received 240 mg of coenzyme Q10 daily, while the other half received a placebo for six months.
Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.
Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.
Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.
Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.
9.5
Liver disease improvement
Most Useful Review
I don't consume alcohol but suspect I have liver disease. I previously took omega-3s and liver supplements to manage cholesterol, but after menopause, results were lacking. However, after using this product, my latest blood test showed normal LDH levels for the first time in over a decade. It's the only new supplement I've tried, and my diet hasn't changed. I'm curious if this product contributed to the result and plan to continue monitoring.
Menopause
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
CoQ10 enhances cognitive function
Coenzyme Q10 treatment ameliorates cognitive deficits by modulating mitochondrial functions in surgically induced menopause.
Most Relevant Research
We aimed to understand how cognitive decline occurs after menopause, particularly due to decreased ovarian function and estrogen. To explore this, we studied the effects of Coenzyme Q10 (CoQ10), a substance known for its potential health benefits, on cognitive impairment in post-menopausal mice.
After four weeks of ovariectomy, which simulates menopause, we observed significant cognitive deficits in the mice, as measured by popular tests like the Morris water maze and elevated plus maze. However, when we gave these mice CoQ10 daily for four weeks, we saw a remarkable improvement in their cognitive functions.
We also investigated the underlying reasons for this decline by looking at mitochondrial functions in the brain. Our findings revealed that the activity of several key components of the mitochondrial electron transport chain was significantly reduced in the ovariectomized mice. These changes were associated with increased oxidative stress, indicated by high levels of reactive oxygen species and protein damage.
Interestingly, CoQ10 supplementation helped mitigate these mitochondrial dysfunctions and oxidative stress, leading to improved cognitive performance in the mice. Therefore, it seems that CoQ10 has a positive effect in addressing cognitive decline related to menopause by supporting mitochondrial health and reducing oxidative stress.
After four weeks of ovariectomy, which simulates menopause, we observed significant cognitive deficits in the mice, as measured by popular tests like the Morris water maze and elevated plus maze. However, when we gave these mice CoQ10 daily for four weeks, we saw a remarkable improvement in their cognitive functions.
We also investigated the underlying reasons for this decline by looking at mitochondrial functions in the brain. Our findings revealed that the activity of several key components of the mitochondrial electron transport chain was significantly reduced in the ovariectomized mice. These changes were associated with increased oxidative stress, indicated by high levels of reactive oxygen species and protein damage.
Interestingly, CoQ10 supplementation helped mitigate these mitochondrial dysfunctions and oxidative stress, leading to improved cognitive performance in the mice. Therefore, it seems that CoQ10 has a positive effect in addressing cognitive decline related to menopause by supporting mitochondrial health and reducing oxidative stress.
8.8
LDH normalised
Most Useful Review
I don't consume alcohol but suspect familial hypercholesterolemia. After menopause, my LDH levels rose despite taking omega-3s and liver-supportive supplements. I had little expectation when trying this product, but after a blood test, my LDH was normal for the first time in over 10 years. There were no significant changes in my diet, and this was the only supplement I used since the last test. I'm curious if the red yeast rice or Q10 contributed to this result. I plan to continue using it and see what the next test shows.
Acne
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 1 Review
8.5
8
Supplement may ease isotretinoin side effects
A dietary supplement to reduce side effects of oral isotretinoin therapy in acne patients.
Most Relevant Research
We undertook a study to see if a dietary supplement containing gamma linolenic acid, vitamin E, vitamin C, beta-carotene, coenzyme Q10, and Vitis Vitifera could help reduce common side effects linked to oral isotretinoin treatment for acne. This treatment is well-known for causing dry skin, redness, and peeling—issues that can make patients less willing to stick with their medication.
To explore this, we worked with 48 patients suffering from nodular acne, splitting them into two groups. One group received isotretinoin alongside the dietary supplement, while the other group only took isotretinoin for a duration of six months. We carefully measured various factors, including acne severity, hydration levels, and skin conditions such as erythema and dryness. We also inquired about how often patients adhered to their prescribed treatment.
Our findings revealed that those who used the dietary supplement experienced fewer side effects compared to those who just took isotretinoin. Specifically, they reported less erythema and dryness, as well as feeling more hydrated overall. Additionally, we noted an increase in treatment adherence in the group that took the supplement. Thanks to its antioxidant and moisturizing properties, this dietary supplement could indeed be a helpful addition for anyone undergoing isotretinoin therapy, making the journey a bit easier for patients.
To explore this, we worked with 48 patients suffering from nodular acne, splitting them into two groups. One group received isotretinoin alongside the dietary supplement, while the other group only took isotretinoin for a duration of six months. We carefully measured various factors, including acne severity, hydration levels, and skin conditions such as erythema and dryness. We also inquired about how often patients adhered to their prescribed treatment.
Our findings revealed that those who used the dietary supplement experienced fewer side effects compared to those who just took isotretinoin. Specifically, they reported less erythema and dryness, as well as feeling more hydrated overall. Additionally, we noted an increase in treatment adherence in the group that took the supplement. Thanks to its antioxidant and moisturizing properties, this dietary supplement could indeed be a helpful addition for anyone undergoing isotretinoin therapy, making the journey a bit easier for patients.
8.8
Improved skin condition
Most Useful Review
I used this for three months and observed an improvement in my facial skin's condition. I would recommend it for treating complex acne.
Cardiovascular Disease
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
USERS' SCORE
Good
Based on 34 Reviews
8.5
9
CoQ-10 reduces mortality, improves capacity
Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis.
Most Relevant Research
We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.
In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.
In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
8.8
No side effects
Most Useful Review
This supplement works well for cardiovascular disease. I take it on my doctor's recommendation to lower my cholesterol, as I don’t tolerate statins. There are no side effects, and my test results have improved slightly, so I will continue taking it.
Diarrhea
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 1 Review
8.5
7
Riboflavin may improve symptoms
Therapeutic trial in the first three Asian cases of ethylmalonic encephalopathy: response to riboflavin.
Most Relevant Research
We observed three Korean girls suffering from ethylmalonic encephalopathy, marking the first known cases in Asia. Through treatment with riboflavin and coenzyme Q10, we noted slight improvements in their motor functions, cognitive behaviors, and notably, their chronic mucoid diarrhea.
Although the improvements were modest, the connection between these treatments and their impact on diarrhea is intriguing. It's worth mentioning that since both riboflavin and coenzyme Q10 were used in the study, we cannot definitively isolate the effects of coenzyme Q10 on diarrhea alone.
The precise cause of ethylmalonic encephalopathy is still unclear, but our findings suggest that riboflavin may offer some benefit. Overall, while we didn't see a significant breakthrough regarding diarrhea, the potential of these treatments warrants further exploration to understand their full effects.
Although the improvements were modest, the connection between these treatments and their impact on diarrhea is intriguing. It's worth mentioning that since both riboflavin and coenzyme Q10 were used in the study, we cannot definitively isolate the effects of coenzyme Q10 on diarrhea alone.
The precise cause of ethylmalonic encephalopathy is still unclear, but our findings suggest that riboflavin may offer some benefit. Overall, while we didn't see a significant breakthrough regarding diarrhea, the potential of these treatments warrants further exploration to understand their full effects.
8.8
Improved digestion
Most Useful Review
The ingredients and quantity are sufficient. After a week of consuming, I've noticed a significant reaction in my digestion. My bowels are very active, though thankfully not experiencing diarrhea.
Frozen Shoulder
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Improved mobility
Most Useful Review
Mr. Cholesterol needs to be managed, so I purchased this for preventative care. He has noticed a significant improvement in the stiffness of his shoulder and neck, related to his frozen shoulder. The product contains Q10 and does not require additional supplements. The quality is excellent, and the small soft capsules have no discernible taste.
Hypothyroidism
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
5.5
USERS' SCORE
Good
Based on 1 Review
8.5
4
CoQ10 levels and thyroid health
[Circulating levels of CoQ10 in hypo- and hyperthyroidism].
Most Relevant Research
We evaluated the levels of Coenzyme Q10 (CoQ10) in patients with hypothyroidism and hyperthyroidism to understand its role in thyroid health. The study included participants from both groups, as well as a control group without thyroid issues, ensuring that no subjects had other cardiovascular or metabolic diseases that could interfere with the results.
Our findings showed that hypothyroid patients had a higher average level of CoQ10 in their blood compared to those with hyperthyroidism. Specifically, hypothyroid patients showed levels of 0.97 mcg/ml, while hyperthyroid patients had only 0.51 mcg/ml, with the control group at 0.73 mcg/ml. This suggests that patients with hypothyroidism may have a greater prevalence of higher CoQ10 levels.
However, we found that the differences were not enough to clearly separate those with normal thyroid function from those with either hypothyroidism or hyperthyroidism. While there is a noted inverse relationship between CoQ10 levels and certain thyroid hormones, this indicates that CoQ10 alone may not provide significant benefits for those specifically dealing with hypothyroidism. More research—especially longitudinal studies—is needed to see how treatment and therapy could potentially affect CoQ10 levels and overall thyroid health in these patients.
Our findings showed that hypothyroid patients had a higher average level of CoQ10 in their blood compared to those with hyperthyroidism. Specifically, hypothyroid patients showed levels of 0.97 mcg/ml, while hyperthyroid patients had only 0.51 mcg/ml, with the control group at 0.73 mcg/ml. This suggests that patients with hypothyroidism may have a greater prevalence of higher CoQ10 levels.
However, we found that the differences were not enough to clearly separate those with normal thyroid function from those with either hypothyroidism or hyperthyroidism. While there is a noted inverse relationship between CoQ10 levels and certain thyroid hormones, this indicates that CoQ10 alone may not provide significant benefits for those specifically dealing with hypothyroidism. More research—especially longitudinal studies—is needed to see how treatment and therapy could potentially affect CoQ10 levels and overall thyroid health in these patients.
8.8
Cholesterol decrease
Most Useful Review
Jarrow Formulas' Red Fermented Rice with Coenzyme Q10 serves as a natural alternative to statins. With my mildly elevated cholesterol linked to hypothyroidism, I preferred this option over statins. My doctor suggested trying Red Fermented Rice, which showed positive results in reducing my cholesterol previously. This time, I opted for it again due to its quality, reasonable price, and the benefit of swift free delivery for orders over £55 to a convenient location.
Knee Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
CoQ10 alleviates knee osteoarthritis
Coenzyme Q10 ameliorates pain and cartilage degradation in a rat model of osteoarthritis by regulating nitric oxide and inflammatory cytokines.
Most Relevant Research
We explored the impact of Coenzyme Q10 (CoQ10) on knee pain and cartilage health using a rat model of osteoarthritis (OA). Our investigation involved inducing OA in rats through an injection of monosodium iodoacetate into the knee joint. Subsequently, we administered CoQ10 orally starting on the fourth day after the injection.
Pain severity was evaluated by assessing tactile sensitivity, and we also examined the state of cartilage by measuring its thickness and proteoglycan levels. Notably, CoQ10 demonstrated a significant reduction in pain, indicated by increased pain withdrawal thresholds. We observed that the treatment led to a decrease in cartilage degeneration as well.
Moreover, CoQ10 lowered the levels of several inflammatory markers associated with OA, including matrix metalloproteinase-13 and various interleukins. Based on our findings, we conclude that CoQ10 is a promising option for alleviating pain and protecting cartilage in individuals suffering from osteoarthritis.
Pain severity was evaluated by assessing tactile sensitivity, and we also examined the state of cartilage by measuring its thickness and proteoglycan levels. Notably, CoQ10 demonstrated a significant reduction in pain, indicated by increased pain withdrawal thresholds. We observed that the treatment led to a decrease in cartilage degeneration as well.
Moreover, CoQ10 lowered the levels of several inflammatory markers associated with OA, including matrix metalloproteinase-13 and various interleukins. Based on our findings, we conclude that CoQ10 is a promising option for alleviating pain and protecting cartilage in individuals suffering from osteoarthritis.
8.8
Knee pain relief
Most Useful Review
Works well in two weeks! I have high cholesterol, and after taking this supplement daily for two weeks, my knee pain has nearly disappeared!
Bone Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.4
10
Effective treatment
Most Useful Review
Works well. Red yeast rice lowered my cholesterol by 30 points. Statins give me bone pain, so I've refused them. I pair this product with diet and exercise—no need for a statin.
Dizziness
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.4
7
CoQ10's uncertain effects on dizziness
Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome.
Most Relevant Research
We explored the potential benefits of coenzyme Q10 (CoQ10) in addressing dizziness associated with Meniere-like syndrome. CoQ10 is known to play a crucial role in energy production within cells, particularly those in the heart, and it has been observed to have various health benefits.
In our review of the available research, we noted that CoQ10 may help improve immune function, which can indirectly assist individuals experiencing symptoms like vertigo or dizziness. While there is recognition of CoQ10's positive effects on heart health, the specific impact on dizziness remains somewhat uncertain.
We found that although trials suggested improvements in various cardiovascular conditions, the isolated effectiveness of CoQ10 for treating dizziness specifically wasn't definitively established in the studies reviewed. Thus, we remain cautiously optimistic about its potential while emphasizing the need for further research.
In our review of the available research, we noted that CoQ10 may help improve immune function, which can indirectly assist individuals experiencing symptoms like vertigo or dizziness. While there is recognition of CoQ10's positive effects on heart health, the specific impact on dizziness remains somewhat uncertain.
We found that although trials suggested improvements in various cardiovascular conditions, the isolated effectiveness of CoQ10 for treating dizziness specifically wasn't definitively established in the studies reviewed. Thus, we remain cautiously optimistic about its potential while emphasizing the need for further research.
9.5
Dizziness improvement
Most Useful Review
Last month, after my cholesterol levels were significantly elevated post-Covid, my doctor suggested pills. However, I opted for Red Yeast Rice and coenzyme Q10. Within a week, the dizziness subsided, and I regained my energy and zest for life. I didn't expect such a notable effect. Tomorrow, I will go for another biochemical blood test for my cholesterol. I’m confident everything will be fine.
Headache
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 6 Reviews
8.4
8
Coenzyme Q10 shows effectiveness against migraines
A Comparative Study on the Efficacy of Coenzyme Q10 and Amitriptyline in the Prophylactic Treatment of Migraine Headaches in Children: A Randomized Controlled Trial.
Most Relevant Research
We investigated the effectiveness of coenzyme Q10 in treating migraines in children, comparing it with the commonly prescribed medication, amitriptyline. Our study involved 72 children, aged 5 to 15, who met the criteria for migraine diagnosis set by the International Headache Society.
Over a three-month period, we observed that coenzyme Q10 had positive therapeutic effects, particularly for those requiring long-term treatment. While amitriptyline provided quicker results, the differences between the two treatments in effectiveness were not significantly noticeable after three months. Both treatments led to improvements in the quality of life for the children involved.
Importantly, we noted that children taking amitriptyline experienced more side effects compared to those receiving coenzyme Q10. This finding positions coenzyme Q10 as a promising option due to its comparable effectiveness and better tolerated adverse effect profile.
Over a three-month period, we observed that coenzyme Q10 had positive therapeutic effects, particularly for those requiring long-term treatment. While amitriptyline provided quicker results, the differences between the two treatments in effectiveness were not significantly noticeable after three months. Both treatments led to improvements in the quality of life for the children involved.
Importantly, we noted that children taking amitriptyline experienced more side effects compared to those receiving coenzyme Q10. This finding positions coenzyme Q10 as a promising option due to its comparable effectiveness and better tolerated adverse effect profile.
9.5
Headache relief
Most Useful Review
I had two health check-ups within three months. My cholesterol metabolism was poor, with a total of 279mg in my first blood test. After taking this red yeast rice for one month, my total cholesterol dropped to 224mg, and remarkably, the headache has disappeared. I will continue to take one pill daily to maintain my health and will keep buying it.
High Cholesterol
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.2
USERS' SCORE
Good
Based on 275 Reviews
8.3
9
CoQ10 lowers cholesterol levels
Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials.
Most Relevant Research
We delved into the effects of coenzyme Q10 (CoQ10) supplementation on cholesterol levels in adults to determine how it can influence lipid profiles. Through a thorough meta-analysis of fifty randomized controlled trials involving nearly 2800 participants, we explored its potential benefits for reducing cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
9.5
Effective cholesterol treatment
Most Useful Review
Working drug! It’s important to note that red rice extracts may inhibit the synthesis of coenzyme Q10 (CoQ10), essential for heart health. If you're taking fermented red rice, consider supplementing with 100mg of CoQ10 daily. Unlike pharmaceutical statins, the natural statins in red rice have fewer side effects. This red rice is beneficial, as it contains CoQ10.
Reflux
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 2 Reviews
8.3
9
CoQ10 may improve heart failure symptoms
Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators.
Most Relevant Research
We investigated the role of coenzyme Q10 (CoQ10) as a supplementary treatment for patients suffering from congestive heart failure, particularly focusing on its impact on reflux symptoms. In this study, we enrolled 2,664 patients across 173 centers in Italy, all of whom were already on standard heart failure treatments. Over three months, participants took daily doses of CoQ10 ranging from 50 to 150 mg, with most having 100 mg.
At the end of the three-month period, we recorded various clinical symptoms. Notably, among patients experiencing reflux, 71.81% reported some level of improvement. This suggests that CoQ10 could offer additional benefits when it comes to managing reflux as a symptom of heart failure.
While we observed favorable trends, we also noted that the improvements could not be solely attributed to CoQ10, given that patients continued their standard treatments. The low rate of side effects, with only 1.5% experiencing adverse reactions, adds to the treatment's appeal. Overall, this study indicates that CoQ10 might enhance quality of life for heart failure patients, including those with reflux symptoms.
At the end of the three-month period, we recorded various clinical symptoms. Notably, among patients experiencing reflux, 71.81% reported some level of improvement. This suggests that CoQ10 could offer additional benefits when it comes to managing reflux as a symptom of heart failure.
While we observed favorable trends, we also noted that the improvements could not be solely attributed to CoQ10, given that patients continued their standard treatments. The low rate of side effects, with only 1.5% experiencing adverse reactions, adds to the treatment's appeal. Overall, this study indicates that CoQ10 might enhance quality of life for heart failure patients, including those with reflux symptoms.
9.5
No reflux experienced
Most Useful Review
I have been taking red rice yeast for a couple of years to manage reflux and cholesterol as I cannot take statins. It is very effective. I take it in the evening before bed and usually enjoy a reflux-free night, and my cholesterol remains healthy.
Nausea
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
USERS' SCORE
Good
Based on 1 Review
8.2
9.5
Coenzyme Q10 alleviates nausea
[Mitochondrial encephalomyopathy (focal cytochrome c oxidase deficiency) with transient episodes of muscle weakness and elevation of serum creatine kinase activity].
Most Relevant Research
We explored the effects of coenzyme Q10 treatment in a 17-year-old boy with mitochondrial encephalomyopathy, characterized by episodes of muscle weakness and related symptoms such as fatigue, nausea, and vomiting. This patient experienced three episodes over several years, during which his serum creatine kinase levels spiked.
During the intervals between these episodes, the boy showed no muscle weakness and maintained normal levels of creatine kinase. However, increased levels of lactic acid and pyruvic acid were found in his blood following exercise, resulting in acidosis. This situation was further examined through an EEG, muscle biopsy, and mitochondrial enzyme activity analysis which revealed a specific deficiency in cytochrome c oxidase.
After administering a large quantity of coenzyme Q10, we observed a significant improvement. The patient no longer experienced episodes of muscle weakness or nausea, and the atypical increases in lactic acid and pyruvic acid after exercise tests vanished. This suggests that coenzyme Q10 may effectively alleviate certain symptoms tied to mitochondrial dysfunction, particularly nausea.
During the intervals between these episodes, the boy showed no muscle weakness and maintained normal levels of creatine kinase. However, increased levels of lactic acid and pyruvic acid were found in his blood following exercise, resulting in acidosis. This situation was further examined through an EEG, muscle biopsy, and mitochondrial enzyme activity analysis which revealed a specific deficiency in cytochrome c oxidase.
After administering a large quantity of coenzyme Q10, we observed a significant improvement. The patient no longer experienced episodes of muscle weakness or nausea, and the atypical increases in lactic acid and pyruvic acid after exercise tests vanished. This suggests that coenzyme Q10 may effectively alleviate certain symptoms tied to mitochondrial dysfunction, particularly nausea.
5
No nausea experienced
Most Useful Review
I started drinking this supplement instead of taking statins, which I had consumed for a month. The statins caused persistent nausea and periodic headaches. However, I have not experienced anything like that from this supplement yet. I expect the full effect will be apparent after two months of use and once I check my blood counts.
Blood Clot
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
USERS' SCORE
Good
Based on 18 Reviews
8.1
9
CoQ10 reduces harmful blood clots
Coenzyme Q10 Upregulates Platelet cAMP/PKA Pathway and Attenuates Integrin αIIbβ3 Signaling and Thrombus Growth.
Most Relevant Research
We explored how coenzyme Q10 (CoQ10), a natural compound found in various foods, impacts blood clotting functions. Through a well-structured study, we utilized a randomized, double-blind, placebo-controlled trial with dyslipidemic patients, alongside in vitro tests on human platelets.
Our findings demonstrated that CoQ10 effectively reduces platelet aggregation, granule secretion, platelet spreading, and clot retraction. This means that CoQ10 can help prevent excessive blood clot formation, which is crucial for cardiovascular health.
We observed that CoQ10 works mainly by enhancing a signaling pathway involving cyclic AMP (cAMP) which ultimately diminishes the signaling of integrin αIIbβ3, a key player in platelet function. In addition, the treatment showed promising results in reducing thrombus growth in an animal model, suggesting significant in vivo benefits as well.
This study highlights the potential of CoQ10 supplementation as a protective measure for individuals at risk of cardiovascular diseases by regulating platelet-related processes involved in clotting.
Our findings demonstrated that CoQ10 effectively reduces platelet aggregation, granule secretion, platelet spreading, and clot retraction. This means that CoQ10 can help prevent excessive blood clot formation, which is crucial for cardiovascular health.
We observed that CoQ10 works mainly by enhancing a signaling pathway involving cyclic AMP (cAMP) which ultimately diminishes the signaling of integrin αIIbβ3, a key player in platelet function. In addition, the treatment showed promising results in reducing thrombus growth in an animal model, suggesting significant in vivo benefits as well.
This study highlights the potential of CoQ10 supplementation as a protective measure for individuals at risk of cardiovascular diseases by regulating platelet-related processes involved in clotting.
9.5
Cholesterol nearly normal
Most Useful Review
I purchased this for my husband, who has high cholesterol. After three months of use, his cholesterol levels dropped nearly to normal. I recommend it to anyone with high cholesterol.
Leg Cramps
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.1
9.5
Leg cramps improved
Most Useful Review
I used Lipitor for a few months following my stroke, but it caused severe leg cramps. My RN wife recommended Red Yeast Rice, which I have taken for over 10 years without issues and with reduced cholesterol levels.
Heartburn
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8
2.5
Caused heartburn
Most Useful Review
I experienced heartburn after taking the capsule, likely due to my gastritis, which prompted me to stop using it.
Constipation
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.8
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.8
4
Ubiquinol shows mixed effects
Effect of Ubiquinol Intake on Defecation Frequency and Stool Form: A Prospective, Double-Blinded, Randomized Control Study.
Most Relevant Research
We conducted a study to examine how coenzyme Q10, in its reduced form known as ubiquinol, might affect constipation in individuals dealing with daily abdominal discomfort. Using a robust, double-blind, randomized control design, we enlisted forty-one patients who experienced either constipation or diarrhea. Participants were split evenly into two groups, with one receiving 150 mg of ubiquinol each day for twelve weeks, while the other group received a placebo.
Over the course of the study, we had participants keep a daily diary to monitor their defecation frequency and the consistency of their stools, following the Bristol Stool Form Scale. After twelve weeks, we noticed some interesting changes. The ubiquinol group reported a slight decrease in defecation frequency, averaging -0.1 times a day, while the placebo group saw an increase of +0.3 times a day. However, there was no significant change in stool form for the ubiquinol group, while the placebo group’s scores improved.
On the brighter side, we also found that the ubiquinol group experienced a notable improvement in their overall health perception, reflected in their quality of life scores. In contrast, there were no significant changes in the placebo group’s scores. Overall, our findings suggest that ubiquinol may modify bowel habits and enhance the quality of life for patients suffering from abdominal distress, despite the small drop in defecation frequency among those taking it.
Over the course of the study, we had participants keep a daily diary to monitor their defecation frequency and the consistency of their stools, following the Bristol Stool Form Scale. After twelve weeks, we noticed some interesting changes. The ubiquinol group reported a slight decrease in defecation frequency, averaging -0.1 times a day, while the placebo group saw an increase of +0.3 times a day. However, there was no significant change in stool form for the ubiquinol group, while the placebo group’s scores improved.
On the brighter side, we also found that the ubiquinol group experienced a notable improvement in their overall health perception, reflected in their quality of life scores. In contrast, there were no significant changes in the placebo group’s scores. Overall, our findings suggest that ubiquinol may modify bowel habits and enhance the quality of life for patients suffering from abdominal distress, despite the small drop in defecation frequency among those taking it.
9.5
No constipation side-effect
Most Useful Review
Excellent! It’s very effective and doesn’t cause constipation like other treatments. I’m awaiting analysis to check my cholesterol.
Kidney Stones
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
8
CoQ10 may improve kidney health
The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo-controlled clinical trial.
Most Relevant Research
We explored the effectiveness of coenzyme Q10 (CoQ10) in protecting renal function in patients dealing with kidney stones who underwent extracorporeal shockwave lithotripsy (ESWL). Our study involved 100 participants randomly assigned to receive either CoQ10 or a placebo, helping us compare the outcomes of each group.
Over the course of the study, we saw promising results from those who took CoQ10. There was a significant improvement in kidney function markers, such as a notable increase in glomerular filtration. Additionally, levels of certain hormones and interleukins linked to blood vessel function and inflammation showed enhancement in the CoQ10 group, contributing to the overall health of the kidneys after the procedure.
However, it’s important to mention that we did not observe significant changes in oxidative stress parameters, which means that while CoQ10 helped with kidney function, it didn't seem to reduce oxidative stress levels as expected. Nonetheless, this research highlights the potential of CoQ10 as a protective agent for the kidneys during treatments like ESWL, suggesting a beneficial preconditioning effect before such procedures.
Over the course of the study, we saw promising results from those who took CoQ10. There was a significant improvement in kidney function markers, such as a notable increase in glomerular filtration. Additionally, levels of certain hormones and interleukins linked to blood vessel function and inflammation showed enhancement in the CoQ10 group, contributing to the overall health of the kidneys after the procedure.
However, it’s important to mention that we did not observe significant changes in oxidative stress parameters, which means that while CoQ10 helped with kidney function, it didn't seem to reduce oxidative stress levels as expected. Nonetheless, this research highlights the potential of CoQ10 as a protective agent for the kidneys during treatments like ESWL, suggesting a beneficial preconditioning effect before such procedures.
0
Unbearable pain
Most Useful Review
The pain in my kidney is unbearable. I used it for a week and could not endure the discomfort! Are there others like me?
Bloating
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.1
9.5
No bloating now
Most Useful Review
I liked it. Red rice is high in antioxidants and fibre, helping to lower cholesterol and prevent high blood sugar. After six months of use, I've seen an improvement in my digestion, with no bloating. My cholesterol is lower, and the product's natural ingredients are a big plus. It's convenient, and I recommend it.
Autoimmune Disorder
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.6
USERS' SCORE
Medium or Average
Based on 3 Reviews
6.8
9.5
Idebenone improves lupus symptoms
Improved Mitochondrial Metabolism and Reduced Inflammation Following Attenuation of Murine Lupus With Coenzyme Q10 Analog Idebenone.
Most Relevant Research
We explored the potential benefits of idebenone, a synthetic analog of coenzyme Q10, in treating autoimmune disorders, specifically lupus, in mouse models. By administering idebenone to mice with lupus for eight weeks, we aimed to investigate its impact on disease activity and organ damage.
Our findings showed that idebenone led to a significant reduction in disease severity. Mice that received idebenone exhibited lower mortality rates and improvements in kidney function, indicated by reduced glomerular inflammation and lower levels of certain inflammatory markers. The treatment also minimized the production of proinflammatory cytokines and enhanced mitochondrial metabolism.
Besides benefiting the kidneys, idebenone diminished markers of inflammation throughout the body, which is crucial since lupus often results in systemic damage. Importantly, we noticed that idebenone improved overall metabolism in these mice without causing obvious side effects.
This research supports the idea that modulating mitochondrial function can be a promising therapeutic strategy for managing lupus, opening the door for future studies on its effectiveness in humans.
Our findings showed that idebenone led to a significant reduction in disease severity. Mice that received idebenone exhibited lower mortality rates and improvements in kidney function, indicated by reduced glomerular inflammation and lower levels of certain inflammatory markers. The treatment also minimized the production of proinflammatory cytokines and enhanced mitochondrial metabolism.
Besides benefiting the kidneys, idebenone diminished markers of inflammation throughout the body, which is crucial since lupus often results in systemic damage. Importantly, we noticed that idebenone improved overall metabolism in these mice without causing obvious side effects.
This research supports the idea that modulating mitochondrial function can be a promising therapeutic strategy for managing lupus, opening the door for future studies on its effectiveness in humans.
2.5
No results received
Most Useful Review
I bought this to help my husband lower his cholesterol levels, but it had no effect. I've since switched to another supplement that has shown better results.
Chest Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Medium or Average
Based on 6 Reviews
6.6
8
Coenzyme Q10 improves angina symptoms
[Coenzyme q10 in complex therapy of patients with ischemic heart disease].
Most Relevant Research
We assessed the effects of coenzyme Q10 on patients suffering from ischemic heart disease, specifically those experiencing stable class II-III angina. In our study, we added coenzyme Q10 at a dosage of 60 mg per day for eight weeks to the standard treatment regimen these patients were already following.
The results showed that this addition significantly improved the clinical status of the patients. Importantly, we did not observe any clinically significant side effects associated with the use of coenzyme Q10. This suggests that it could be a beneficial adjunct therapy for individuals dealing with chest pain related to cardiac issues, enhancing their treatment experience without additional risk.
The results showed that this addition significantly improved the clinical status of the patients. Importantly, we did not observe any clinically significant side effects associated with the use of coenzyme Q10. This suggests that it could be a beneficial adjunct therapy for individuals dealing with chest pain related to cardiac issues, enhancing their treatment experience without additional risk.
9.5
Cholesterol lowered
Most Useful Review
Works well. RYR lowered my cholesterol by 30 points. Statins cause me leg pain, so I refuse to take them. I combine this product with diet and exercise. There’s no need for statins.
Back Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Medium or Average
Based on 4 Reviews
6.4
0
Severe pain
Most Useful Review
The pain in my kidney was unbearable. I used it for a week, but the pain was too much to handle! Is there anyone else experiencing this?
