Jarrow Formulas Alpha Lipoic Sustain 300 mg

We aimed to understand how alpha-lipoic acid (LA) affects wound healing in diabetic conditions. The study involved five groups of mice: healthy controls, wounded healthy mice, wounded diabetic mice, and two groups of wounded diabetic mice treated with different doses of LA for 14 days.

Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.

This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.

9.5

Weight loss aid

Most Useful Review

Works well for glucose control. Being menopausal and hypoglycaemic has made it challenging to lose weight. I now follow a keto lifestyle and take these pills at mealtimes twice daily, complemented by Berberine, Keto BHB, and Forskolin. This combination, along with my diet, has enabled me to lose 20lbs and over 25 inches while maintaining healthy blood sugar levels. The pills are a bit large but manageable. As noted on the bottle, consult your endocrinologist or PCP if you are treated for diabetes or glucose control!

α-Lipoic Acid Ameliorates Arsenic-Induced Lipid Disorders by Promoting Peroxisomal β-Oxidation and Reducing Lipophagy in Chicken Hepatocyte.

Most Relevant Research

We explored the protective effects of alpha-lipoic acid (LA) against liver damage caused by arsenic, a well-known environmental toxin. In our examination, we uncovered the mechanisms through which arsenic harms the liver, including its ability to induce autophagy, apoptosis, and oxidative stress, as well as disrupt lipid metabolism.

Our findings revealed that arsenic negatively impacts liver function primarily by reducing the expression of SIRT1, damaging mitochondria, and impairing a process called peroxisomal β-oxidation. This disruption leads to an increase in lipid accumulation and enhances lipophagy, which is the body's way of breaking down fats. However, when we administered LA, we observed a marked improvement. LA appeared to counteract the damage inflicted by arsenic by boosting SIRT1 levels, improving mitochondrial function, and encouraging peroxisomal β-oxidation.

This study clearly illustrates the potential of alpha-lipoic acid as a protective agent against liver injury due to arsenic exposure. By promoting better lipid metabolism and reducing harmful fat buildup, LA could serve as a valuable option for those affected by liver diseases induced by environmental toxins.

9.5

Heals damaged liver

Most Useful Review

A must. I never want to be without this one. I take one per day to heal my damaged liver due to fatty liver disease. This helps the entire body and I believe everyone should be taking it. It's a super antioxidant that does many things. I know of a doctor in Las Cruces who administers it in an IV to treat cancer, including pancreatic cancer.

Leg Cramps

Alpha lipoic is a fantastic product! My mother suffers from diabetic neuropathy and leg cramps. This is the only thing that genuinely helps! I would recommend it as a pharmacist and as a daughter.

Allergies

Effective allergy relief

Most Useful Review

A great product for my allergies and immune system.

Heartburn

Heartburn issues resolved

Most Useful Review

Made the switch - and loving it. I used to take Genceutic Naturals R-Alpha Lipoic (300mg) and suffered from heartburn and acid reflux constantly. I switched to Jarrow’s sustain tablets and haven’t had any troubles since. While the tablets are a bit large, they are easy to swallow due to their coating. I would certainly recommend them!

Neuropathy

SCIENTIFIC SCORE

Possibly Effective

Based on 3 Researches

Alpha-lipoic acid reduces AGEs

Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy.

Most Relevant Research

We investigated the potential benefits of alpha-lipoic acid (ALA) for patients with type 2 diabetes mellitus (T2DM) suffering from neuropathy. Over six months, we treated 54 patients with a daily dose of 600 mg of ALA while keeping their current oral medications unchanged. We also included a control group of 24 matched individuals who did not experience neuropathy.

Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.

Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.

9.5

Pain relief

Most Useful Review

Alpha Lipoic Sustain works GREAT! I take it to alleviate pain from idiopathic peripheral neuropathy. Prescription Lyrica didn't work well and caused side effects, muddling my thoughts! Alpha Lipoic Sustain is effective, and I take about 1,200 mg (or 4 tablets daily) without any side effects. Jarrow seems to be the best among the alpha lipoic acids I've tried.

Reflux

Made the switch, and I am loving it. I used to take Genceutic Naturals R-Alpha Lipoic (300mg) and suffered from constant heartburn and reflux. Since switching to Jarrow's sustain tablets, I haven't experienced any issues. The tablets are a bit large but easy to swallow thanks to the coating. I would definitely recommend them!

Hair Loss

SCIENTIFIC SCORE

Possibly Effective

Based on 16 Researches

Biotin therapy improves hair growth

Biotinidase deficiency characterized by skin and hair findings.

Most Relevant Research

We explored the effects of biotin treatment on hair loss through a case study of a girl diagnosed with biotinidase deficiency. Despite having no notable family history of the condition, her symptoms included problematic dermatitis, yellow hair, and alopecia.

After identifying low levels of biotinase and significant metabolic increases, the girl was found to have two specific mutations in her BTD gene linked to this deficiency. Following the diagnosis, we observed a clear response to biotin supplementation, with an initial dosage of 20 mg per day.

Remarkably, her dermatitis improved within a month, and her hair color returned to normal after three months of treatment. These findings suggest that biotin replacement therapy can have significant positive outcomes in cases related to biotinidase deficiency, connecting biotin to effective hair restoration.

Stable blood sugar

Most Useful Review

Alpha-lipoic acid + biotin. I have taken alpha-lipoic acid with my doctor's approval for years. It has numerous benefits, including stabilising my sugar metabolism as a pre-diabetic, which contributes to my hair loss. I’ve noticed that my hair loss has lessened when taking it with biotin.

Stroke

SCIENTIFIC SCORE

Moderately Effective

Based on 3 Researches

Alpha-Lipoic Acid Shows Stroke Potential

Ischemic Microenvironment-Targeted Bioinspired Lipoprotein Sequentially Penetrates Cerebral Ischemic Lesions to Rescue Ischemic Stroke.

Most Relevant Research

We examined how alpha-lipoic acid (ALA) impacts stroke recovery, particularly through a newly developed delivery system designed to target ischemic brain lesions. This system uses bioinspired lipoproteins to carry ALA, allowing it to reach the areas most affected by stroke more effectively than standard methods.

In experiments with mice experiencing a transient middle cerebral artery occlusion (a model for stroke), we observed that the ALA-loaded lipoprotein system accumulated significantly in the ischemic brain tissue—2.29 times more than a nontargeted version. This increased delivery resulted in several positive outcomes, such as restoring neurological function, reducing brain cell death, and lessening inflammation, which is key for healing after a stroke.

Overall, our findings suggest that ALA, when delivered effectively to the right brain areas, has considerable potential to improve recovery from ischemic strokes. This innovative approach opens new avenues for treating strokes and enhancing patient outcomes.

Reduced stroke damage

Most Useful Review

Fantastic benefits. This supplement has numerous health advantages and was recommended by my holistic doctor. Lipoic acid is known to reduce oxidative stress and enhance insulin sensitivity, improve lipids, and reduce the risk of stroke, among other benefits. It not only helps in improving metabolic syndrome but also aids in visual function and protects against conditions like cataracts.