Supplement Facts
Serving Size: 1 Vegetarian Tablet
Amount Per Serving
%DV
Folate [as (6S)-5-Methyltetrahydrofolate, Calcium salt]
1,700 mcg○
425%
The product is found useful for the following medical conditions
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.1
USERS' SCORE
Good
Based on 14 Reviews
8.6
9
We examined the effects of folic acid as an add-on treatment for major depression alongside traditional medications like SSRIs and SNRIs. After reviewing six randomized control trials, we found that patients receiving folic acid showed better progress.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options.
9
Significant improvement
Most Useful Review
23 people found this helpful
The depression killer! I have experienced depression all my life. Methyl folate has significantly aided me in overcoming depression and mood swings. Its potency surpasses most other products, which is sufficient to do the job. Additionally, I take choline for better nerve transmission and exercise daily, yielding numerous benefits that I can't list fully here. My doctor was astonished by my progress. I hope this assists you in your journey.
Updated: Mar 2026
Hair Loss details
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Good
Based on 8 Reviews
8.6
8
Folic acid treatment shows promise
We explored the effects of folic acid on hair loss in a three-week-old Charolais calf showing signs typical of folic acid deficiency. After starting daily folic acid therapy at a dose of 1 mg/kg, we observed that the crusts and patches diminished within two weeks. Remarkably, hair growth resumed, and within two months, the calf returned to a normal state. This indicates that folic acid could be an effective treatment for certain types of alopecia related to deficiencies in this essential nutrient.
10
Stopped hair loss
Most Useful Review
11 people found this helpful
It was what I needed! After four long years of intense hair loss, I decided to investigate further through new blood tests to find out what was happening. The results showed very low folic acid levels. I started supplementing as directed by the doctor, and the miracle happened! My hair stopped falling out, and the few grey hairs I had started to grow closer to my natural colour. I will continue to supplement and am very confident that soon the results will be 100%. I recommend this quality brand!
Updated: Mar 2026
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7
USERS' SCORE
Good
Based on 3 Reviews
8.5
9
Folic acid improves rheumatoid arthritis treatment
We explored the use of ginger-derived extracellular vesicles modified with folic acid to treat rheumatoid arthritis, a painful autoimmune condition. By enhancing these vesicles to target the inflammatory cells in affected joints, we found that they help shift the immune response towards healing. Our in vitro and in vivo studies showed promising results: these folic acid-infused vesicles not only concentrated in the inflamed areas but also significantly reduced RA symptoms. This suggests that folic acid-modified vesicles could be a safe and effective alternative treatment option for RA.
9
Improved condition
Most Useful Review
163 people found this helpful
After an illness, I ordered this for my father. He takes it alongside other medications and feels much better. The drug is effective and does not cause side effects.
Updated: Mar 2026
Heart Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
USERS' SCORE
Good
Based on 5 Reviews
8.3
8
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
9
Great for heart health
Most Useful Review
Great Supplement for Heart Health.
Updated: Mar 2026
Hypothyroidism details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.3
9
Folic Acid Improves Cognitive Function
We explored how folic acid (FA) affects cognitive decline linked to hypothyroidism in a rat model. Over seven weeks, rats received PTU to induce hypothyroidism and were given varying doses of FA.
The results were promising, showing that FA improved memory and learning in tested tasks. The higher the FA dose, the better the outcomes, with reduced cognitive decline and changes in brain enzyme activity.
This suggests that folic acid may offer protective benefits against cognitive issues related to hypothyroidism, primarily by managing oxidative stress.
The results were promising, showing that FA improved memory and learning in tested tasks. The higher the FA dose, the better the outcomes, with reduced cognitive decline and changes in brain enzyme activity.
This suggests that folic acid may offer protective benefits against cognitive issues related to hypothyroidism, primarily by managing oxidative stress.
7.5
No side effects
Most Useful Review
6 people found this helpful
It's not a bad medication. I bought it for the protocol for correcting disorders related to hypothyroidism, and I haven't experienced any unpleasant side effects.
Updated: Mar 2026
Liver Disease details
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.8
USERS' SCORE
Good
Based on 2 Reviews
8.3
9
Folate treatment aids liver fat reduction
We investigated the effects of folic acid treatment on nonalcoholic fatty liver disease (NAFLD), a condition where excess fat builds up in the liver, often linked to obesity and insulin resistance. Our research revealed that giving folic acid to mice on a high-fat diet helped improve their glucose tolerance and insulin sensitivity, alongside reducing unhealthy fat levels in their liver cells.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
7.5
Immunity enhancement
Most Useful Review
I opted for this form of folic acid - folate. My order arrived promptly and in perfect condition. I took it alongside vitamin B12, and I’m pleased with the results; my general health has improved, and I feel more resilient against diseases. Folates assist in combating cholesterol plaques in blood vessels and lower homocysteine levels in liver disease.
Updated: Mar 2026
Polycystic Ovary Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.3
9
Boosts energy levels
Most Useful Review
L-methylfolate is vital for women! I am thrilled to find such a high dosage here. It enhances energy levels, aids with Polycystic ovary syndrome, and improves metabolism while regulating the nervous system.
Updated: Apr 2025
Attention Deficit Hyperactivity Disorder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.2
7.5
Improved mood
Most Useful Review
4 people found this helpful
I chose this folate due to its large dosage and volume, as I needed it to restore my methylation cycle affected by stress and deficiencies. After experiencing depression for the first time, I identified a B9 deficiency. My attempts to improve my condition with various vitamins showed some progress, but not entirely. Upon starting folic acid and B12, I noticed my mood beginning to normalise. Unlike tryptophan, which was ineffective, folic acid proved beneficial. I later switched to a more bioavailable form of folate and studied methylation processes, recognising their importance. It's crucial not to overlook this if you're struggling. I've combined it with SAMe, which also yielded positive results. However, the high dosage made me excessively sleepy, a contrast to folic acid. Be cautious with dosage - I had to split the pill. Best of health!
Updated: Mar 2026
Cardiovascular Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.4
USERS' SCORE
Good
Based on 6 Reviews
8.2
8
We examined the connection between folic acid levels and stroke risk in a study involving nearly 5,000 individuals from a Chinese community. We discovered that participants with higher folate levels had a significantly lower risk of experiencing strokes.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
8
Cardiovascular health support
Most Useful Review
1 people found this helpful
Life Extension's folic acid supplement is certified Non-GMO. It supports a well-functioning cardiovascular system and maintains normal homocysteine levels, which is crucial for cognitive function, especially in the elderly. Combining it with B12 enhances its effects.
Updated: Mar 2026
Flu details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.2
7.5
Increased energy levels
Most Useful Review
Folic acid in an active metabolic form, I take it alongside B6 and B12. This supplement comes in small, user-friendly pills that dissolve quickly, so it’s essential to swallow and drink water promptly, as they can sometimes remain in the esophagus. An excellent supplement for strengthening health, as I've noticed an increase in energy. There are clear benefits; the ingredient is natural, and its taste is neutral. The size is moderate, and the advantages of price, composition, and quality cannot be overlooked. I feel significant improvement in my metabolism, digestion, and nervous system.
Updated: Mar 2026
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.2
7
We set out to understand how folic acid (FA) levels relate to high cholesterol and the risk of atherosclerosis, a leading cause of heart disease. Utilizing a method called Mendelian randomization, which leverages genetic data to uncover causal relationships, we explored the connection between genetically determined FA levels and atherosclerosis risk.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
9
Improved health
Most Useful Review
7 people found this helpful
Many people are unaware of the dangers posed by high homocysteine levels. I didn’t test for this indicator and discovered I was at great risk. Years of work-related stress had resulted in chronic fatigue due to high levels of homocysteine. Supplementing with folic acid helped convert it to harmless substances. I feel much healthier now and my recent homocysteine tests are normal. I recommend everyone monitor this issue and take timely action.
Updated: Mar 2026
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.2
7.5
Reduces swelling
Most Useful Review
Thompson's routine is both effective and reasonably priced. The quality is excellent, and it enhances vitamin C absorption, which should be taken together. The ingredients and size are just right. I find it increases the elasticity of blood vessel walls, reduces capillary permeability, and diminishes fragility. Rutin alleviates inflammation in the veins and significantly affects leg swelling. I take one a day and have noticed a relief in my leg cramps.
Updated: Apr 2025
Anemia details
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.8
USERS' SCORE
Moderately Good
Based on 20 Reviews
7.9
9.5
Family education improves anemia treatment
We investigated how family-centered health education influences adherence to iron-folic acid supplements and improves anemia among pregnant women. Through a quasi-experimental trial, we compared results from intervention and control groups, focusing on women aged 14-16 weeks with anemia.
Our findings showed that this educational approach led to notable increases in participants' knowledge and practices regarding anemia management. Significant drops in moderate and mild anemia rates were observed, along with improvements in hemoglobin and ferritin levels. This suggests that better education can effectively enhance anemia status in expectant mothers.
Our findings showed that this educational approach led to notable increases in participants' knowledge and practices regarding anemia management. Significant drops in moderate and mild anemia rates were observed, along with improvements in hemoglobin and ferritin levels. This suggests that better education can effectively enhance anemia status in expectant mothers.
9
Eliminated anaemia
Most Useful Review
3 people found this helpful
For the first time, my blood results showed no anaemia. I have been using this alongside vitamin B12 for optimal results.
Updated: Mar 2026
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.5
9
We explored how folic acid (FA) given during pregnancy influences anxiety and cognitive issues in postpartum mice. By administering FA at different doses, we observed noteworthy improvements in anxiety and cognitive performance among the mice that received a higher dosage.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
9
Noticeable difference
Most Useful Review
13 people found this helpful
This product has significantly helped my family members suffering from anxiety, panic attacks, and depression, attributed to the MTHFR C677T double mutation. It’s truly worthwhile to incorporate it into our daily supplements.
Updated: Apr 2025
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