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Supplement Facts
Serving Size: 1 Vegetarian Tablet
Amount Per Serving
%DV
Folate [as (6S)-5-Methyltetrahydrofolate, Calcium salt]
1,700 mcg○
425%
The product is found useful for the following medical conditions
Cardiovascular Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Good
Based on 14 Reviews
8.9
8
Folate's potential in heart health
Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment.
Most Relevant Research
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
9.5
Effective folate supplement
Most Useful Review
This folate is excellent! I’m already ordering my third package from different brands. It’s the ideal formula for those planning a pregnancy or managing anaemia and elevated homocysteine, linked to cardiovascular disease. I recommend it wholeheartedly!
Autoimmune Disorder
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.2
USERS' SCORE
Good
Based on 5 Reviews
8.7
7
PANS/PANDAS and folate treatment
Folate Receptor Alpha Autoantibodies in the Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) Population.
Most Relevant Research
We aimed to understand how folate receptor alpha autoantibodies (FRAAs) relate to symptoms in children diagnosed with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) and Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). We analyzed serum samples from 47 children, aged 6 to 18, who carried these diagnoses.
Our results showed that a significant number of these children—about 63.8%—had binding or blocking FRAAs. Additionally, certain symptoms, like severe tics, linked with higher FRAA binding titers. Notably, we observed that kids with autism spectrum disorder (ASD) had lower binding titers of FRAAs.
A remarkable case highlighted how treatment with leucovorin, a form of folate, resulted in symptom improvements in a child with PANS/PANDAS who tested positive for FRAAs. These findings suggest that abnormalities in folate metabolism could play a role in the symptomatology of PANS/PANDAS, presenting the potential for folate-based therapies to be a viable treatment option.
Overall, this study sheds light on the connection between folate-related factors and pediatric neuropsychiatric disorders, calling for further research into leucovorin as a targeted treatment.
Our results showed that a significant number of these children—about 63.8%—had binding or blocking FRAAs. Additionally, certain symptoms, like severe tics, linked with higher FRAA binding titers. Notably, we observed that kids with autism spectrum disorder (ASD) had lower binding titers of FRAAs.
A remarkable case highlighted how treatment with leucovorin, a form of folate, resulted in symptom improvements in a child with PANS/PANDAS who tested positive for FRAAs. These findings suggest that abnormalities in folate metabolism could play a role in the symptomatology of PANS/PANDAS, presenting the potential for folate-based therapies to be a viable treatment option.
Overall, this study sheds light on the connection between folate-related factors and pediatric neuropsychiatric disorders, calling for further research into leucovorin as a targeted treatment.
9.5
Improved condition
Most Useful Review
After an illness, I ordered this for my father. He takes it alongside other medications and feels much better. The drug is effective and does not cause side effects.
Anemia
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.1
USERS' SCORE
Good
Based on 20 Reviews
8.6
9
Folate supplementation improves anemia
Effect of School-Based Weekly Iron and Folic Acid Supplementation Program on the Serum Folate Status of Adolescent Girls in Sidama Region, Southern Ethiopia: Comparative Cross-Sectional Study.
Most Relevant Research
We conducted a study to understand how a school-based program offering weekly iron and folic acid supplements affects anemia, particularly focusing on the serum folate levels in adolescent girls aged 10 to 19 in the Sidama Region of Southern Ethiopia.
Our research compared 165 girls from schools participating in the supplementation program to 165 girls from schools without this initiative. We measured the serum folate levels, alongside hemoglobin concentrations, to get a clearer picture of the program's effectiveness.
The results were promising. We observed that the girls receiving the supplements had a significantly higher mean serum folate concentration of 9.76 ng/mL compared to 7.38 ng/mL in those who did not receive the supplementation. Additionally, the hemoglobin levels were higher in the supplemented group, suggesting a positive effect on overall health.
This highlights the importance of the WIFAS program not just for iron levels but also for folate status, indicating a crucial step in tackling anemia in vulnerable populations. We are optimistic that this evidence can help advocate for the program's expansion in areas facing deficiencies in both iron and folate.
Our research compared 165 girls from schools participating in the supplementation program to 165 girls from schools without this initiative. We measured the serum folate levels, alongside hemoglobin concentrations, to get a clearer picture of the program's effectiveness.
The results were promising. We observed that the girls receiving the supplements had a significantly higher mean serum folate concentration of 9.76 ng/mL compared to 7.38 ng/mL in those who did not receive the supplementation. Additionally, the hemoglobin levels were higher in the supplemented group, suggesting a positive effect on overall health.
This highlights the importance of the WIFAS program not just for iron levels but also for folate status, indicating a crucial step in tackling anemia in vulnerable populations. We are optimistic that this evidence can help advocate for the program's expansion in areas facing deficiencies in both iron and folate.
9.5
Helps prevent anaemia
Most Useful Review
A lack of folic acid can lead to megaloblastic anaemia, altering blood structure. Symptoms include fatigue, attention issues, migraines, palpitations, and a crimson tongue. This product is beneficial.
Heart Disease
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.5
USERS' SCORE
Good
Based on 12 Reviews
8.6
9
Folic acid reduces CHD risk
Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population.
Most Relevant Research
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
8.8
Supports cellular health
Most Useful Review
Having researched dietary supplements, I can say that Optimized Folate 1700 mcg DFE is impressive. It’s highly bioavailable, helps with amino acid metabolism, and supports cardiovascular health by regulating homocysteine levels. I take one capsule daily with no side effects.
Liver Disease
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.8
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Folate treatment aids liver fat reduction
DNA hypermethylation-induced suppression of ALKBH5 is required for folic acid to alleviate hepatic lipid deposition by enhancing autophagy in an ATG12-dependent manner.
Most Relevant Research
We investigated the effects of folic acid treatment on nonalcoholic fatty liver disease (NAFLD), a condition where excess fat builds up in the liver, often linked to obesity and insulin resistance. Our research revealed that giving folic acid to mice on a high-fat diet helped improve their glucose tolerance and insulin sensitivity, alongside reducing unhealthy fat levels in their liver cells.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
8.8
Immunity enhancement
Most Useful Review
I opted for this form of folic acid - folate. My order arrived promptly and in perfect condition. I took it alongside vitamin B12, and I’m pleased with the results; my general health has improved, and I feel more resilient against diseases. Folates assist in combating cholesterol plaques in blood vessels and lower homocysteine levels in liver disease.
Anxiety
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Folic acid alleviates pain-induced anxiety
Long-term folic acid treatment relieves chronic inflammatory pain and pain-induced anxiety by reducing MMP2 expression in rats.
Most Relevant Research
We investigated the potential effects of folic acid on anxiety arising from chronic inflammatory pain. Using a group of adult rats, we induced inflammatory pain by injecting them with complete Freund's adjuvant into their hindpaw. Pain levels and behaviors were measured through paw withdrawal tests to monitor mechanical and thermal sensitivity.
Our findings revealed that the rats experienced heightened pain levels, correlating with increased expression of Matrix metalloproteinase 2 (MMP2) in certain nerve regions. Most importantly, we discovered that long-term treatment with folic acid not only lowered MMP2 levels but also provided significant relief from the chronic pain. Additionally, this treatment helped reduce anxiety related to pain, showing that folic acid could play a protective role in managing both chronic inflammatory pain and the anxiety that often accompanies it.
The results suggest that folic acid could be a valuable therapeutic option for tackling both pain and the psychological distress that can follow chronic inflammation. This dual benefit opens the door for further exploration of folic acid in pain management strategies.
Our findings revealed that the rats experienced heightened pain levels, correlating with increased expression of Matrix metalloproteinase 2 (MMP2) in certain nerve regions. Most importantly, we discovered that long-term treatment with folic acid not only lowered MMP2 levels but also provided significant relief from the chronic pain. Additionally, this treatment helped reduce anxiety related to pain, showing that folic acid could play a protective role in managing both chronic inflammatory pain and the anxiety that often accompanies it.
The results suggest that folic acid could be a valuable therapeutic option for tackling both pain and the psychological distress that can follow chronic inflammation. This dual benefit opens the door for further exploration of folic acid in pain management strategies.
9.5
Noticeable difference
Most Useful Review
This product has significantly helped my family members suffering from anxiety, panic attacks, and depression, attributed to the MTHFR C677T double mutation. It’s truly worthwhile to incorporate it into our daily supplements.
Tinnitus
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Essential brain support
Most Useful Review
An essential supplement for the brain. It helps me cope with noise and tinnitus.
Headache
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
USERS' SCORE
Good
Based on 1 Review
8.4
9
Folate intake may reduce headaches
Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey.
Most Relevant Research
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
7.5
No more headaches
Most Useful Review
Best form of methylfolate. I started taking it when I discovered I was pregnant. Initially, I had headaches with the folate, but taking my vitamins at dinner helped my body adjust. No headaches have occurred for several months now, which is a relief.
High Cholesterol
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.2
7
Folic acid reduces cholesterol risk
Genetically predicted lipid traits mediate the association between folic acid and atherosclerosis.
Most Relevant Research
We set out to understand how folic acid (FA) levels relate to high cholesterol and the risk of atherosclerosis, a leading cause of heart disease. Utilizing a method called Mendelian randomization, which leverages genetic data to uncover causal relationships, we explored the connection between genetically determined FA levels and atherosclerosis risk.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
9.5
Improved health
Most Useful Review
Many people are unaware of the dangers posed by high homocysteine levels. I didn’t test for this indicator and discovered I was at great risk. Years of work-related stress had resulted in chronic fatigue due to high levels of homocysteine. Supplementing with folic acid helped convert it to harmless substances. I feel much healthier now and my recent homocysteine tests are normal. I recommend everyone monitor this issue and take timely action.
Hypothyroidism
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8.2
9
Folic acid aids hypothyroid cognition
Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats.
Most Relevant Research
Our study aimed to understand how folic acid (FA) impacts cognitive issues linked to hypothyroidism. We used a rat model, treating them with propylthiouracil (PTU) to induce hypothyroidism. After administering various doses of folic acid over several weeks, we monitored behavior through tests designed to assess learning and memory skills.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
6.3
No side effects
Most Useful Review
It's not a bad medication. I bought it for the protocol for correcting disorders related to hypothyroidism, and I haven't experienced any unpleasant side effects.
Blood Clot
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.1
9
Folic acid impacts blood clotting
Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential.
Most Relevant Research
We investigated how folic acid affects blood clotting, particularly when exposed to carbon black (CB), a common industrial substance. In our study with adult C57BL/6 mice, we found that prolonged exposure to CB led to increased blood clotting potential due to changes in the spleen, where extra blood cell production occurs.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
9.5
Health improvement noted
Most Useful Review
Many are unaware of the dangers of high blood homocysteine levels, as I was. Chronic work stress caused mine to rise, putting me at risk for blood clots. To mitigate this, I needed substances like folic acid that convert harmful homocysteine into beneficial compounds. I've been using an active form of folate from a reputable brand consistently, and my levels normalised, leading to a significant improvement in my health. I strongly recommend monitoring these levels and taking action as necessary.
Pelvic Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8
9.5
Joint pain relief
Most Useful Review
Has helped significantly with my joint pain.
