5/23/2025
Supplement Facts
Serving Size: 1 Vegetarian Tablet
Amount Per Serving
%DV
Folate [as (6S)-5-Methyltetrahydrofolate, Calcium salt]
1,700 mcg○
425%
The product is found useful for the following medical conditions
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7
USERS' SCORE
Good
Based on 5 Reviews
8.5
We explored the use of ginger-derived extracellular vesicles modified with folic acid to treat rheumatoid arthritis, a painful autoimmune condition. By enhancing these vesicles to target the inflammatory cells in affected joints, we found that they help shift the immune response towards healing. Our in vitro and in vivo studies showed promising results: these folic acid-infused vesicles not only concentrated in the inflamed areas but also significantly reduced RA symptoms. This suggests that folic acid-modified vesicles could be a safe and effective alternative treatment option for RA.
9
Improved condition
Most Useful Review
163 people found this helpful
After an illness, I ordered this for my father. He takes it alongside other medications and feels much better. The drug is effective and does not cause side effects.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.1
USERS' SCORE
Good
Based on 14 Reviews
8.5
We examined the effects of folic acid as an add-on treatment for major depression alongside traditional medications like SSRIs and SNRIs. After reviewing six randomized control trials, we found that patients receiving folic acid showed better progress.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options.
9
Significant improvement
Most Useful Review
23 people found this helpful
The depression killer! I have experienced depression all my life. Methyl folate has significantly aided me in overcoming depression and mood swings. Its potency surpasses most other products, which is sufficient to do the job. Additionally, I take choline for better nerve transmission and exercise daily, yielding numerous benefits that I can't list fully here. My doctor was astonished by my progress. I hope this assists you in your journey.
Hair Loss details
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Good
Based on 7 Reviews
8.4
We explored the effects of folic acid on hair loss in a three-week-old Charolais calf showing signs typical of folic acid deficiency. After starting daily folic acid therapy at a dose of 1 mg/kg, we observed that the crusts and patches diminished within two weeks. Remarkably, hair growth resumed, and within two months, the calf returned to a normal state. This indicates that folic acid could be an effective treatment for certain types of alopecia related to deficiencies in this essential nutrient.
9
Eliminated hair loss
Most Useful Review
1 people found this helpful
Very effective. A daily intake of 1000 mcg raises Ferritin levels, effectively eliminating fatigue and hair loss.
Anemia details
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.8
USERS' SCORE
Good
Based on 20 Reviews
8.3
9.5
Family education improves anemia treatment
Singh G, Ranjitha R, Baskaran P, Goel AD, Gupta MK, et al. Family-centered Health Education Intervention for Improving Iron-folic Acid Adherence and Anemia Reduction among Antenatal Mothers in Rural Jodhpur: A Quasi-experimental Study. Indian J Public Health. 2024;68:495. doi:10.4103/ijph.ijph_844_23
We investigated how family-centered health education influences adherence to iron-folic acid supplements and improves anemia among pregnant women. Through a quasi-experimental trial, we compared results from intervention and control groups, focusing on women aged 14-16 weeks with anemia.
Our findings showed that this educational approach led to notable increases in participants' knowledge and practices regarding anemia management. Significant drops in moderate and mild anemia rates were observed, along with improvements in hemoglobin and ferritin levels. This suggests that better education can effectively enhance anemia status in expectant mothers.
Our findings showed that this educational approach led to notable increases in participants' knowledge and practices regarding anemia management. Significant drops in moderate and mild anemia rates were observed, along with improvements in hemoglobin and ferritin levels. This suggests that better education can effectively enhance anemia status in expectant mothers.
9
Helps prevent anaemia
Most Useful Review
7 people found this helpful
A lack of folic acid can lead to megaloblastic anaemia, altering blood structure. Symptoms include fatigue, attention issues, migraines, palpitations, and a crimson tongue. This product is beneficial.
Cardiovascular Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.4
USERS' SCORE
Good
Based on 14 Reviews
8.3
We examined the connection between folic acid levels and stroke risk in a study involving nearly 5,000 individuals from a Chinese community. We discovered that participants with higher folate levels had a significantly lower risk of experiencing strokes.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
9
Effective folate supplement
Most Useful Review
16 people found this helpful
This folate is excellent! I’m already ordering my third package from different brands. It’s the ideal formula for those planning a pregnancy or managing anaemia and elevated homocysteine, linked to cardiovascular disease. I recommend it wholeheartedly!
Hypothyroidism details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.3
We explored how folic acid (FA) affects cognitive decline linked to hypothyroidism in a rat model. Over seven weeks, rats received PTU to induce hypothyroidism and were given varying doses of FA.
The results were promising, showing that FA improved memory and learning in tested tasks. The higher the FA dose, the better the outcomes, with reduced cognitive decline and changes in brain enzyme activity.
This suggests that folic acid may offer protective benefits against cognitive issues related to hypothyroidism, primarily by managing oxidative stress.
The results were promising, showing that FA improved memory and learning in tested tasks. The higher the FA dose, the better the outcomes, with reduced cognitive decline and changes in brain enzyme activity.
This suggests that folic acid may offer protective benefits against cognitive issues related to hypothyroidism, primarily by managing oxidative stress.
7.5
No side effects
Most Useful Review
6 people found this helpful
It's not a bad medication. I bought it for the protocol for correcting disorders related to hypothyroidism, and I haven't experienced any unpleasant side effects.
Liver Disease details
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.8
USERS' SCORE
Good
Based on 2 Reviews
8.3
We investigated the effects of folic acid treatment on nonalcoholic fatty liver disease (NAFLD), a condition where excess fat builds up in the liver, often linked to obesity and insulin resistance. Our research revealed that giving folic acid to mice on a high-fat diet helped improve their glucose tolerance and insulin sensitivity, alongside reducing unhealthy fat levels in their liver cells.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
7.5
Immunity enhancement
Most Useful Review
I opted for this form of folic acid - folate. My order arrived promptly and in perfect condition. I took it alongside vitamin B12, and I’m pleased with the results; my general health has improved, and I feel more resilient against diseases. Folates assist in combating cholesterol plaques in blood vessels and lower homocysteine levels in liver disease.
Polycystic Ovary Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.3
9
Boosts energy levels
Most Useful Review
L-methylfolate is vital for women! I am thrilled to find such a high dosage here. It enhances energy levels, aids with Polycystic ovary syndrome, and improves metabolism while regulating the nervous system.
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.2
We set out to understand how folic acid (FA) levels relate to high cholesterol and the risk of atherosclerosis, a leading cause of heart disease. Utilizing a method called Mendelian randomization, which leverages genetic data to uncover causal relationships, we explored the connection between genetically determined FA levels and atherosclerosis risk.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
9
Improved health
Most Useful Review
7 people found this helpful
Many people are unaware of the dangers posed by high homocysteine levels. I didn’t test for this indicator and discovered I was at great risk. Years of work-related stress had resulted in chronic fatigue due to high levels of homocysteine. Supplementing with folic acid helped convert it to harmless substances. I feel much healthier now and my recent homocysteine tests are normal. I recommend everyone monitor this issue and take timely action.
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.2
7.5
Reduces swelling
Most Useful Review
Thompson's routine is both effective and reasonably priced. The quality is excellent, and it enhances vitamin C absorption, which should be taken together. The ingredients and size are just right. I find it increases the elasticity of blood vessel walls, reduces capillary permeability, and diminishes fragility. Rutin alleviates inflammation in the veins and significantly affects leg swelling. I take one a day and have noticed a relief in my leg cramps.
Blood Clot details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8
We explored a unique case of recurrent fainting after hysteroscopy, ultimately revealed as cerebral venous sinus thrombosis (CVST). This rare condition can mimic symptoms of more common complications like TURP syndrome, making diagnosis tricky.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
9
Health improvement noted
Most Useful Review
7 people found this helpful
Many are unaware of the dangers of high blood homocysteine levels, as I was. Chronic work stress caused mine to rise, putting me at risk for blood clots. To mitigate this, I needed substances like folic acid that convert harmful homocysteine into beneficial compounds. I've been using an active form of folate from a reputable brand consistently, and my levels normalised, leading to a significant improvement in my health. I strongly recommend monitoring these levels and taking action as necessary.
Heart Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
USERS' SCORE
Good
Based on 12 Reviews
8
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
7.5
Supports cellular health
Most Useful Review
1 people found this helpful
Having researched dietary supplements, I can say that Optimized Folate 1700 mcg DFE is impressive. It’s highly bioavailable, helps with amino acid metabolism, and supports cardiovascular health by regulating homocysteine levels. I take one capsule daily with no side effects.
Pelvic Pain details
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.8
We explored an innovative treatment for chronic bacterial prostatitis (CBP) by creating antibiotic-loaded nanoparticles modified with folic acid. These nanoparticles can effectively target and penetrate the prostate tissues where inflammation and pain occur.
In animal models, the folic acid-modified nanomedicine significantly alleviated pelvic pain and reduced inflammatory markers. This targeted approach enhances antibiotic delivery and improves treatment outcomes for CBP. Although the study showcases promising results, more research is needed to translate these findings to human patients.
In animal models, the folic acid-modified nanomedicine significantly alleviated pelvic pain and reduced inflammatory markers. This targeted approach enhances antibiotic delivery and improves treatment outcomes for CBP. Although the study showcases promising results, more research is needed to translate these findings to human patients.
9
Joint pain relief
Most Useful Review
Has helped significantly with my joint pain.
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.5
We explored how folic acid (FA) given during pregnancy influences anxiety and cognitive issues in postpartum mice. By administering FA at different doses, we observed noteworthy improvements in anxiety and cognitive performance among the mice that received a higher dosage.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
9
Noticeable difference
Most Useful Review
13 people found this helpful
This product has significantly helped my family members suffering from anxiety, panic attacks, and depression, attributed to the MTHFR C677T double mutation. It’s truly worthwhile to incorporate it into our daily supplements.
