Life Extension Zinc Caps

Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med. 2001;7:49.

Based on 9 Researches

Zinc cream alleviates cold sores

We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.

Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.

As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.

Prevention of colds

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149 people found this helpful

If taken alongside vitamin C, this is an excellent remedy for treating and preventing colds.

Heart Disease details

Zinc benefits heart health post-cisplatin

Based on 4 Researches

Al-Lbban AM. Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats. Braz J Biol. 2025;84:e287764. doi:10.1590/1519-6984.287764

We explored the potential benefits of zinc oxide nanoparticles (ZnONPs) in preventing heart damage caused by cisplatin, a powerful chemotherapy drug known for its efficacy but also for its side effects, particularly cardiotoxicity.

In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.

As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.

Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.

Blood pressure improvement

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70 people found this helpful

Excellent! This is the best vitamin I have found. After taking it for a week, my blood pressure improved dramatically and my heart rate began to normalise.

We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.

Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.

Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!

Acne improvement

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651 people found this helpful

Excellent vitamin, it helped combat acne. After starting the supplement, my skin cleared up significantly. My hair has also become shinier and thicker.

Back Pain details

Bhardwaj A, Swe KMM, Sinha NK. Treatment for osteoporosis in people with beta-thalassaemia. Cochrane Database Syst Rev. 2023;5:CD010429. doi:10.1002/14651858.CD010429.pub3

Zinc may boost bone density

We explored how zinc supplementation might help with back pain in individuals with beta-thalassaemia. The research included a randomized controlled trial with 42 participants, where some received zinc while others were given a placebo.

Results showed that zinc supplementation likely increased the bone mineral density (BMD) at the lumbar spine and hip after 12 to 18 months of treatment. This improvement in bone health could suggest potential benefits in pain relief, although the study didn’t directly measure back pain outcomes.

Even though the findings about BMD improvements are promising, we should be cautious. The trial didn't provide direct evidence on whether zinc specifically alleviates back pain. It’s essential to recognize that while we observed positive changes in bone density, interpreting this as a definitive solution for back pain would be premature.

Thus, further research is necessary to connect zinc's effects on bone health to actual pain relief in order to offer clearer guidance on its use as a treatment for back pain.

Improved back pain

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25 people found this helpful

I took this zinc supplement to aid recovery as it is a key component of the powerful antioxidant superoxide dismutase (SOD). I immediately noticed relief from heart pain and an increase in physical endurance despite sleep deprivation. My stress resistance has improved, leading to less anxiety and more calmness. Sleep quality has also improved. I recommend a 100mg dosage for first-time users.

Blurred Vision details

Optimised vision support

Zinc capsules are crucial for older individuals where deficiency is a problem. These supplements play an essential role in immune support, especially during the aging process. We have crafted a low-cost formula that integrates highly absorbable OptiZinc with zinc citrate, yielding a potent 50 mg dose per capsule. These offer extensive benefits including supporting cardiovascular and nervous systems while addressing vision health, and enhancing the body’s natural immune response.

Cardiovascular Disease details

Guo J, Ma T, Wang B, Xing B, Huang L, et al. Zn protects H9C2 cardiomyocytes by alleviating MAMs-associated apoptosis and calcium signaling dysregulation. Cell Signal. 2025;127:111629. doi:10.1016/j.cellsig.2025.111629

Zinc counters heart cell injury

We set out to investigate how zinc might help protect heart cells from damage caused by a lack of blood flow, known as myocardial ischemia-reperfusion injury (MIRI). Using H9C2 cells, which are derived from rat heart tissue, we simulated this injury by depriving these cells of oxygen and then reintroducing it while treating them with zinc.

Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.

Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.

Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.

Improved healing

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263 people found this helpful

Highly dosed and well-absorbed zinc is essential for proper immune function and brain development. A deficiency can lead to cognitive impairment and mental disorders. Zinc is also crucial for maintaining taste, vision, and testosterone production in men. My family used zinc monomethionine for deficiency; it aided my father's ulcer healing and improved my husband's vision and testosterone levels. Be cautious, though, as excessive zinc can interfere with copper absorption.

Chronic Cough details

12 people found this helpful

The doctor prescribed zinc to boost my immunity in autumn. After contracting coronavirus, I started taking one capsule daily, and my symptoms improved within four days. My sense of smell and touch returned by day five, and I noticed less hair fall and fewer skin issues. Highly recommended for preventing chronic cough and promoting overall health!

Atrial Septal Defect details

Notable behaviour change

I administered this to my child with atrial septal defect. There was noticeable improvement; they were less inclined to chew on books and started pulling everything to their mouth. While behaviour can occasionally elevate, I attribute some of this to other issues, not solely zinc deficiency. Overall, I believe it works! The capsules can be easily divided into three or four parts, making it economical. ❤️ If this information proves useful, a like would be appreciated!

Celiac details

Life Extension Zinc Caps are an excellent addition to my daily vitamin regimen. The high potency of 50 mg is ideal for daily use, and the vegetarian capsules are easy to swallow. As the product is also non-GMO and gluten-free, it aligns perfectly with my requirements. Since I began taking this supplement regularly, I have observed a noticeable enhancement in my immune system and overall well-being. I highly recommend it to anyone seeking a quality zinc supplement.

Hypothyroidism details

Zinc's uncertain role in hypothyroidism

Nikkhah M, Vafa M, Abiri B, Golgiri F, Sarbakhsh P, et al. The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial. Med J Islam Repub Iran. 2024;38:133. doi:10.47176/mjiri.38.133

We conducted a study to investigate the effects of micronutrient supplementation, including zinc, on thyroid function and overall quality of life in patients with hypothyroidism. Our trial involved 104 participants who were receiving levothyroxine and vitamin D. They were randomly assigned to either a group that received a mix of essential nutrients or a placebo group over eight weeks.

We measured various health markers before and after this period, including thyroid hormone levels, cholesterol, insulin resistance, and blood pressure. Our findings suggested that the group receiving the micronutrient supplement experienced improvements in insulin resistance and overall quality of life. However, it’s important to note that the specific effects of zinc alone are somewhat difficult to isolate, as it was part of a combination of nutrients being tested.

Ultimately, while the study indicates potential benefits of micronutrient supplementation for thyroid function in hypothyroid patients, further trials are necessary to clearly define the role of zinc and other nutrients in this context.

Improved absorption

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2 people found this helpful

Most bioavailable zinc exists as it alleviates absorption issues. Life Extension's formula combines OptiZinc with zinc citrate for a potent 50 milligram dose. I found it particularly effective for hypothyroidism treatment. This brand is incomparable in quality, and I highly recommend it.

Influenza details

Nishi K, Yoshimoto S, Nishi S, Nishi T, Nishi R, et al. Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry. In Vivo. 2022;36:2357. doi:10.21873/invivo.12967

Zinc may prevent influenza entry

We investigated how zinc, delivered through epipharyngeal abrasive therapy (EAT), might impact the expression of a key molecule known as Cav1.2, which plays a crucial role in allowing the influenza A virus to enter cells. The study included two groups of patients: one group that received EAT, which involved scratching the epipharyngeal mucosa with a zinc chloride-treated swab, and another group that did not receive this treatment.

By analyzing tissue samples, we observed that the levels of Cav1.2 were significantly lower in the EAT-treated patients compared to those who were not treated. In fact, the expression of Cav1.2 in the patients who underwent EAT was measured to be 4.19 times lower than in the non-treated group. This suggests that the squamous metaplasia induced by EAT might help reduce the entry of the influenza virus by down-regulating this key protein.

Our findings indicate that EAT, through its zinc content, could serve as a simple and effective method to potentially prevent influenza infection by limiting the virus's ability to enter cells.

Prevention recommendation

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4 people found this helpful

The leader in the prevention and treatment of influenza and ARVI! Zinc, paired with vitamin D, is essential for cold prevention. My family takes zinc twice a year for two months as a prophylactic measure. This product is effective; the brand is commendable. I wholeheartedly recommend it.

Yeast Infection details

Zinc's potential against yeast infections

Awassa J, Soulé S, Cornu D, Ruby C, El-Kirat-Chatel S. Understanding the nanoscale adhesion forces between the fungal pathogen and antimicrobial zinc-based layered double hydroxides using single-cell and single-particle force spectroscopy. Nanoscale. 2024;16:5383. doi:10.1039/d3nr06027f

We explored the effects of zinc-based treatments on yeast infections, particularly focusing on the interaction between zinc-aluminum layered double hydroxides (ZnAl LDHs) and the yeast pathogen. Previous concerns regarding antifungal resistance have prompted the search for new treatments, and our study investigates how these zinc compounds might help.

Through careful experimentation, we used atomic force microscopy (AFM) to observe how ZnAl LDH nanoparticles interacted with yeast cells at a very small scale. Our results showed that these nanoparticles not only had visible antifungal properties but also caused significant damage to the yeast cell walls.

The force measurements revealed strong adhesive interactions between the zinc compounds and the yeast cells, implying that these interactions may play a crucial role in the antifungal activity. In contrast, control substances showed little to no adhesion, underscoring the unique properties of zinc-based treatments.

Overall, our findings suggest a promising avenue in the fight against yeast infections, showing how zinc could help bind to and damage fungal pathogens. It’s an exciting development that offers hope in tackling persistent antifungal resistance issues.

Enhanced skin health

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1 people found this helpful

Various zinc forms exist, but methionine is the best-absorbed. My skin condition improved greatly, with faster healing, reduced inflammation, peeling, and itching. My hair grew quicker and fell out less, and dandruff disappeared. Overall, it boosted my memory, efficiency, and immunity, helping my body resist infections better.

Chronic Fatigue Syndrome details

Zinc supplementation may benefit CFS

Maes M, Mihaylova I, De Ruyter M. Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS. J Affect Disord. 2006;90:141.

We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.

Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.

Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.

Boosted energy levels

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90 people found this helpful

I've battled chronic fatigue syndrome for a long time, searching for a suitable vitamin without side effects. This supplement has given me a surge of energy and significantly improved my condition. I recommend it to anyone looking for relief.

Ear Infection details

Zinc's mixed impact on ear infections

Questionable

Based on 8 Researches

Abba K, Gulani A, Sachdev HS. Zinc supplements for preventing otitis media. Cochrane Database Syst Rev. 2010. doi:10.1002/14651858.CD006639.pub2

We explored whether zinc supplements could help prevent otitis media, which is a common ear infection affecting many, especially young children. Our examination included several randomized, placebo-controlled trials where participants received zinc supplements at least once a week for a minimum of a month.

In total, we identified 12 trials, but only 10 provided sufficient data for analysis. Among healthy children from low-income communities, most studies did not show a clear benefit of zinc on reducing ear infections. However, one trial with over 1600 participants did find a significantly lower incidence of otitis media in those taking zinc, suggesting that it might help. Additionally, a small study focusing on infants with severe malnutrition hinted at potential benefits, yet it is important to note this was based on limited data.

Overall, the evidence isn't definitive—while some results point towards positive effects, particularly in specific groups, many trials did not support the effectiveness of zinc in healthy children. Furthermore, zinc supplements appeared safe, with minimal reports of adverse effects.

Viral support

Most Useful Review

Zinc in a high dosage has been a lifesaver for my acute respiratory infections and colds. It’s essential to take it with food or after meals, as it can induce nausea otherwise.

Low Libido details

7 people found this helpful

Zinc has a special effect on me; it awakens my desire. I would recommend it for those with low libido.

Psoriasis details

Zinc conditioner benefits scalp psoriasis

Based on 5 Researches

Yu C, Yu N, Jiang X, Gao X, Lv S, et al. Efficacy and safety of supramolecular active zinc in the treatment of scalp psoriasis: a multicentre, randomized, observed-blind, parallel-group, placebo- and active-controlled noninferiority trial. Clin Exp Dermatol. 2023;48:1138. doi:10.1093/ced/llad168

We delved into the effectiveness of a zinc-based hair conditioner specifically designed for treating scalp psoriasis. This study was a well-structured clinical trial involving 211 participants, where individuals were divided into three groups: those receiving the specialized zinc treatment, a placebo, and a control group given calcipotriol ointment. Remarkably, the trial was multicenter and observed-blind, which adds credibility to the findings.

Our results revealed that the zinc conditioner led to a 39% disease control rate after four weeks, compared to 25% for the placebo and 37% for the calcipotriol ointment group. This means that the zinc treatment significantly outperformed the placebo while being on par with the active control variant. In essence, those using the zinc product experienced better management of their scalp psoriasis than those using a non-active alternative.

Overall, our findings highlight that a supramolecular active zinc antidandruff formulation is not just effective for treating scalp psoriasis but also helps in maintaining results over time and potentially preventing future flare-ups. This offers a promising new avenue for patients seeking relief from this chronic condition.

7.5

Improves autoimmune conditions

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2 people found this helpful

Zinc is highly effective in treating autoimmune skin diseases, including psoriasis and complex eczema. I take it in courses twice a year and have seen improvements. It strengthens the immune system and supports vision and thyroid health. Importantly, if taking zinc, supplementing with copper is necessary to avoid deficiency.

Cold details

Wieland LS. Zinc for prevention and treatment of the common cold: Summary of a Cochrane review. Explore (NY). 2025;21:103111. doi:10.1016/j.explore.2025.103111

Based on 3 Researches

Zinc’s effects on colds

We explored how zinc might help in treating and preventing the common cold. The study focused on zinc's effects, isolating it from other treatments to understand its true impact on cold symptoms. By doing this, the researchers aimed to clarify whether zinc could genuinely shorten the duration of a cold or alleviate its symptoms.

The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.

This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.

Cold vanished

Most Useful Review

1 people found this helpful

Cold GONE! Killed my cold pronto!!!

Adrenal Gland Disorder details

Zinc is crucial for men, particularly for supporting the adrenal glands and thyroid function! It is well known that zinc boosts the immune system, enhancing the body’s resistance to illness and provides antioxidant benefits. A lack of zinc reduces the productivity of the thymus gland, where T cells mature to fight diseases and tumours. This gland diminishes with age and is largest in infants. For men, I always ensure my spouse takes zinc as it is vital for sperm production and testosterone synthesis. Zinc is also vital for the proper metabolism of vitamin A. Insufficient zinc can significantly hinder protein metabolism and insulin production. One major reason behind a weakened immune system is inadequate zinc levels, leading to elevated cortisol levels, which the adrenal glands produce and is known for its immune-suppressing effects.

Allergies details

Xu H, Tong K, Iwasaki N, Ohgami N, Tazaki A, et al. Alleviating effect of intranasal zinc on symptoms of allergic rhinitis. J Allergy Clin Immunol Glob. 2025;4:100408. doi:10.1016/j.jacig.2025.100408

Zinc may relieve allergy symptoms

We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.

Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.

The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.

Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.

7.5

Improved skin health

Most Useful Review

255 people found this helpful

I appreciated the effects of zinc; it has benefitted my body significantly. My skin has visibly improved, my immune system feels stronger, and my gums have stopped bleeding. I've noticed a reduction in cravings for sweets, and my hair is falling out less while my nails no longer peel. This supplement effectively addresses zinc deficiency without causing allergies, and the taste is subtle.

Bone Pain details

25 people found this helpful

I took zinc alongside magnesium to test its effects, particularly for superoxide dismutase (SOD). I noticed quicker relief from my heart pains, significantly better physical endurance despite chronic sleep deprivation, and notably less anxiety. My sleep has also improved, and I now recommend a dosage of 100mg of zinc daily for those who haven't tried it yet.

Common Cold details

Zinc shortens cold duration variability

Based on 6 Researches

Hemilä H, Chalker E, Tukiainen J. Quantile Treatment Effect of Zinc Lozenges on Common Cold Duration: A Novel Approach to Analyze the Effect of Treatment on Illness Duration. Front Pharmacol. 2022;13:817522. doi:10.3389/fphar.2022.817522

We explored how zinc lozenges affect the duration of the common cold through a detailed analysis of multiple trials. In particular, we focused on the Mossad (1996) trial involving zinc gluconate lozenges, which revealed an average reduction of cold duration by about 4.0 days. While that sounds promising, our findings through a quantile treatment effect (QTE) analysis tell a more nuanced story.

Interestingly, the QTE analysis showed that for individuals suffering from lengthy colds lasting 15 to 17 days, the zinc lozenges could shorten their illness by as much as 8 days. On the flip side, those with shorter, 2-day colds only experienced a 1-day reduction in sickness. This suggests that while zinc may help, its effectiveness varies significantly depending on the initial duration of the cold, making the overall average effect less informative than we might think.

Our examination extended to three trials that used zinc acetate lozenges, yielding a similar average reduction of around 2.7 days. However, again, those averages concealed varying effects for short and long colds, highlighting the importance of looking beyond simple averages in treatment studies.

Overall, we observed that zinc lozenges can indeed help with cold duration, but the extent of that help is very much dependent on how long a person has been suffering. This approach to understanding treatment effects through QTE analysis could have important implications not just for cold treatment but also for analyzing other health outcomes.

Strengthens immunity

Most Useful Review

97 people found this helpful

I often take zinc to support my immune system and improve my skin and hair. This supplement contains OptiZinc, which is easily absorbed and effective. I've noticed a reduction in cold symptoms and skin clarity.

Depression details

Zinc deficiency impacts brain function

Gąsior Ł, Pochwat B, Zaręba-Kozioł M, Włodarczyk J, Grabrucker AM, et al. Proteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. Pharmacol Rep. 2025;77:145. doi:10.1007/s43440-024-00681-7

We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.

We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.

Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.

These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health.

Reduced fatigue

Most Useful Review

14 people found this helpful

This supplement has been effective for everyday fatigue, depression, and lack of energy from withdrawal symptoms of sleeping pills. My family suffers from insomnia due to such symptoms, and I found that adding zinc improved my overall condition, including decreasing irritability.

Insomnia details

Cherasse Y, Saito H, Nagata N, Aritake K, Lazarus M, et al. Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice. Mol Nutr Food Res. 2015;59:2087. doi:10.1002/mnfr.201500082

Based on 3 Researches

Zinc promotes sleep in mice

We explored the effects of zinc on sleep by looking at how it might help with insomnia. In our study, we gave mice a zinc-containing yeast extract and monitored their behavior and brain activity. The results were quite promising.

We found that administering zinc at doses of 40 and 80 mg/kg led to a significant increase in non-rapid eye movement (NREM) sleep. This means that the mice were not only sleeping longer but also showed less activity, which is a good indicator of effective sleep. Interestingly, we did not observe any changes in rapid eye movement (REM) sleep, a crucial sleep phase for dreaming and deep rest.

Importantly, we didn’t see any negative side effects, such as rebound insomnia, within 24 hours after treating the mice. This suggests that zinc could be a safe option for those struggling with sleep issues, unlike other mineral extracts we tested, such as manganese, iron, and copper, which did not affect locomotor activity at all.

Overall, our findings provide the first evidence that zinc has a direct role in promoting sleep, opening up exciting possibilities for new sleep supplements featuring this essential mineral.

Helps with insomnia

Most Useful Review

Zinc stabilises insomnia, depression, and autonomic dysfunction, especially during menopause and old age. The natural quality ingredients relieve stress, stimulate brain function, and enhance concentration while normalising sleep. GABA, as a neurotransmitter, boosts sleep quality, supporting growth hormone release at night. This effective formula mitigates stress factors for deeper and more restorative sleep, with optimal dosage.

Knee Pain details

I liked this product. Previously, zinc often caused me stomach pain after eating, but this supplement didn’t. I noticed an improvement in my skin and it has helped with my knee pain as well. I recommend it for the price and quantity.

Leg Cramps details

Eliminated leg cramps

7 people found this helpful

Since I started taking zinc, my leg cramps and PMS have vanished. I stopped the pill to rely solely on zinc, and my condition has improved significantly. I take one pill regularly and two during my period.

Menopause details

Zinc enhances vitamin D in menopause

Vázquez-Lorente H, Molina-López J, Herrera-Quintana L, Gamarra-Morales Y, López-González B, et al. Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial. J Trace Elem Med Biol. 2021;65:126730. doi:10.1016/j.jtemb.2021.126730

We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.

Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.

Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.

Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.

Essential for menopause

Most Useful Review

Zinc is vital for women during menopause. It regulates hormone production, combats viruses, and restores muscle function, making a significant difference for me. It's crucial to take it correctly—preferably in the morning after a meal—and ideally alongside vitamin D for better absorption.

Ulcer details

Hayashi A, Taki Y, Arai K, Sato S, Higashizono K, et al. Esophageal ulcer related to zinc deficiency following a total gastrectomy. Nutrition. 2023;110:111999. doi:10.1016/j.nut.2023.111999

Based on 16 Researches

Zinc helps heal esophageal ulcers

We delved into an interesting case of a 76-year-old man who developed severe esophageal ulcers, likely due to zinc deficiency following a total gastrectomy. His symptoms included sore throat, heartburn, and difficulty swallowing.

After the diagnosis of zinc deficiency, he began oral zinc treatment. Remarkably, this led to significant symptom relief and visible healing of the ulcers during follow-up imaging. Impressively, he has maintained his zinc supplementation for five years without any recurrence of symptoms. This unique case shines a light on the potential role of zinc in ulcer healing.

Mouth ulcer prevention

Most Useful Review

13 people found this helpful

I tend to get mouth ulcers on my tongue when I run out of zinc. Taking it along with B6 helps cure them easily. It also assists in calming stomach discomfort like heartburn, which tends to linger without sufficient zinc.

Autoimmune Disorder details

Zinc supplementation benefits MS models

Based on 6 Researches

Bayiroglu AF, Acar G, Gulbahce-Mutlu E, Baltaci SB, Mogulkoc R, et al. Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model. J Trace Elem Med Biol. 2024;86:127540. doi:10.1016/j.jtemb.2024.127540

We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.

Significant improvement

Most Useful Review

21 people found this helpful

Good things at affordable prices! My husband suffers from purpura caused by an autoimmune disorder. After trying multiple treatments, including high-unit vitamin B and internal medicine, there was little effect. However, after adding R-lipoic acid and zinc, his skin condition remarkably improved within two months. No more itching or dryness, and his skin has returned to a normal state, allowing him to live without hindrance. Thank you, iHerb and Life Extension, for such effective products!

Bacterial Infection details

I took this zinc during my coronavirus infection, and the fever lasted only two days - the cough and nasal congestion were almost absent. It definitely worked, and I would recommend it to others needing relief.

Diabetes details

Zinc alleviates diabetic muscle atrophy

USERS' SCORE

Good

Based on 11 Reviews

Yu X, Chen X, Wu W, Tang H, Su Y, et al. Zinc Alleviates Diabetic Muscle Atrophy via Modulation of the SIRT1/FoxO1 Autophagy Pathway Through GPR39. J Cachexia Sarcopenia Muscle. 2025;16:e13771. doi:10.1002/jcsm.13771

Our investigation aimed to understand how zinc affects muscle atrophy in diabetes, a serious complication that leads to muscle loss. Using diabetes-induced mice, we treated them with zinc sulfate for six weeks and observed notable improvements in their muscle condition.

We conducted various analyses to evaluate the impact of zinc on autophagy—the process that helps manage muscle mass. The results were promising; zinc appeared to enhance muscle recovery by regulating specific molecular pathways connected to muscle health.

Additionally, our in vitro studies with diabetic muscle cells revealed similar results, with zinc supplementation proving beneficial in reducing excessive autophagy. Overall, this suggests that incorporating zinc into treatment plans could be a promising approach to counteract muscle deterioration in diabetic patients.

Improved absorption

Most Useful Review

I recommend it! I took it when it wasn’t necessary and didn’t regret it. My mother, who has diabetes, says she feels much better now and that it’s absorbed effectively compared to the last brand, with no digestive issues. Highly recommend!

Indigestion details

Zinc-enhanced therapy improves eradication

Ibrahim N, El Said H, Choukair A. Zinc carnosine-based modified bismuth quadruple therapy standard triple therapy for eradication: A randomized controlled study. World J Clin Cases. 2022;10:227. doi:10.12998/wjcc.v10.i1.227

We explored the effectiveness of a modified bismuth quadruple therapy that includes zinc carnosine, in comparison to the traditional triple therapy for treating indigestion caused by Helicobacter pylori infection. In our study, 92 patients with symptoms of dyspepsia and positive breath tests were randomly assigned to receive either the conventional treatment of esomeprazole, amoxicillin, and clarithromycin for 14 days, or a shorter 10-day course of the new therapy that also included bismuth subcitrate and zinc carnosine.

The results were quite revealing. Our findings showed that the modified bismuth quadruple therapy group had a significantly higher eradication rate of 93.5%, compared to 69.6% in the standard treatment group. This suggests that the addition of zinc carnosine to the treatment regimen could enhance the effectiveness of indigestion relief. Importantly, the side effects reported between the two groups were similar, with only mild dizziness noted in those receiving the new therapy.

Overall, the study indicates that a shorter course of therapy that includes zinc carnosine may be a superior option for individuals suffering from indigestion related to Helicobacter pylori. This approach not only appears to work better but also does not lead to more serious side effects, making it an appealing alternative to traditional treatment methods.

No indigestion issues

Most Useful Review

I appreciate this type of zinc because it does not lead to indigestion.

Prostate Cancer details

Zinc's complex role in prostate cancer

Ghimire K, Awasthi BP, Yadav K, Lee J, Kim H, et al. Prostate cancer-selective anticancer action of an oxindole derivative via HO-1-mediated disruption of metabolic reprogramming. Chem Biol Interact. 2025;408:111393. doi:10.1016/j.cbi.2025.111393

We explored the relationship between zinc levels and prostate cancer treatments, particularly focusing on a novel compound known as 3D. This compound showed a strong potential to target prostate cancer cells, contributing to a decrease in their proliferation rates.

Our analysis revealed that compound 3D selectively impacted key metabolic processes in prostate cancer cells by suppressing factors related to energy production, such as lactate levels. Interestingly, it also reduced the activity of transporters involved in zinc absorption while leaving those responsible for zinc export untouched.

We also found that the effectiveness of 3D could be reversed with zinc treatment, highlighting a complicated interaction between zinc and this therapeutic approach. While the compound successfully lowered zinc levels in cells and inhibited cancer growth, it is essential to note that we did not find significant benefits from zinc treatment by itself in the context of this study.

Overall, our findings suggest that targeting zinc metabolism and enhancing heme oxygenase-1 expression could be a promising strategy in prostate cancer therapy, more so than the direct application of zinc itself. The results illustrate the potential for combining innovative small molecules with an understanding of cancer metabolism in the development of treatment strategies.

Enhances testosterone levels

Most Useful Review

1 people found this helpful

Research indicates a zinc-poor diet can reduce testosterone levels in men by almost 80% in five months. Zinc affects the prostate's function and hormone production, with low levels impacting immunity and sex hormone production. This zinc supplement is excellent, especially post-meal, and I highly recommend it.

Swollen Lymph Nodes details

Effective for swelling

21 people found this helpful

Good things at affordable prices with impressive results! My husband suffers from purpura due to autoimmune diseases. He sought medical treatment with internal medicine powder, an external ointment, acupuncture, and other costs, which were rather pricey yet ineffective. Initially, I took high-unit vitamin B complex, C, and D3, but noticed no improvement. After adding R-lipoic acid and zinc, I experienced miraculous improvement daily. Within 2 months, the skin stopped itching, drying, and swelling, and the subcutaneous haemorrhage healed, allowing normal life to resume. Thank you, iHerb, for providing accessible shopping; and Life Extension for their affordable, high-quality health products!

Heart Attack details

Mohamed ATAE, Ragheb MA, Shehata MR, Mohamed AS. In vivo cardioprotective effect of zinc oxide nanoparticles against doxorubicin-induced myocardial infarction by enhancing the antioxidant system and nitric oxide production. J Trace Elem Med Biol. 2024;86:127516. doi:10.1016/j.jtemb.2024.127516

Based on 9 Researches

ZnO NPs protect heart health

We aimed to explore how zinc oxide nanoparticles (ZnO NPs) could protect the heart from damage caused by doxorubicin, a drug that can lead to serious heart issues, including myocardial infarction (MI). Our study involved rats that were injected with doxorubicin to induce MI and then treated with ZnO NPs at two different doses.

Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.

Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.

7.5

Immune support noted

Most Useful Review

At 56, I purchase zinc to bolster my immune system, support my heart, and promote overall health. It's an excellent antioxidant that aids in cleansing blood vessels of cholesterol. The website details the composition and ingredients, with citrates being the most bioavailable forms of minerals. I avoid using zinc alongside iron or calcium, focusing on maintaining physical fitness through exercise and a balanced diet rich in essential vitamins and minerals.

Anemia details

Questionable

Inoue M. Zinc Deficiency Presenting With Diverse Symptoms in a Young Patient: A Case Report. Cureus. 2024;16:e66034. doi:10.7759/cureus.66034

Zinc deficiency linked to anemia

We explored the connection between zinc deficiency and anemia through the case of an 18-year-old woman who faced a series of health issues, including urinary tract infections and insulin dysfunction. After a thorough assessment, she was diagnosed with zinc deficiency, shedding light on how this overlooked issue can impact overall health.

What stood out to us was the rapid recovery the patient experienced after beginning oral zinc supplementation. Zinc plays a critical role in numerous bodily functions, including immune support and protein regulation. By addressing her deficiency, we observed significant improvement in her symptoms, including anemia.

The patient’s diet contained high levels of substances that were inhibiting her zinc absorption, which likely contributed to her condition. This case emphasizes the importance of recognizing zinc deficiency as a potential underlying cause for unexplained health issues, particularly anemia. Prompt diagnosis and treatment can lead to a complete turnaround in the patient's health.

By sharing this experience, we hope to raise awareness among clinicians about the vital role of zinc in managing anemia and encourage timely interventions for patients showing diverse symptoms.

Cold season support

Most Useful Review

I always take zinc during cold season, as it is one of my essential supplements (with vitamin D and C). I consume them regularly and especially at the first signs of illness. It's important to take zinc after meals to avoid nausea. Taking these supplements together reduces the duration of illness. I advise careful consumption based on zinc and copper analysis, as excessive zinc can cause copper deficiency, especially important for one who suffers from anaemia.

Tinnitus details

Zinc intake affects tinnitus risk

Tang D, Shekhawat GS, Burlutsky G, Mitchell P, Gopinath B. The Association between Dietary Intakes of Vitamins and Minerals with Tinnitus. Nutrients. 2024;16. doi:10.3390/nu16152535

We examined how dietary intakes of vitamins and minerals, particularly zinc, could influence the onset and presence of tinnitus, a condition characterized by phantom sounds in the ears. In a study involving nearly 3,000 participants over the age of 50, we identified cases of tinnitus to determine if their dietary habits played a role in their experience of this condition.

The findings indicated that while there were no significant associations between overall vitamin and mineral intake and existing tinnitus prevalence, zinc intake stood out in relation to developing tinnitus over time. Specifically, we observed that lower zinc consumption was linked to a 44% increased risk of experiencing tinnitus over a ten-year period.

Furthermore, we noted that iron intake also showed a significant correlation, with lower iron levels raising incident tinnitus risk by approximately 35%. These results highlight the potential importance of maintaining adequate zinc and iron levels in our diets to help reduce the risk of developing tinnitus.

7.5

Helpful supplement

Most Useful Review

Zinc vegetarian capsules were helpful for my tinnitus after taking them. I recommend continuing with them.

Adenoiditis details

2 people found this helpful

The drug works effectively. Take a dosage of 50 units only if unwell for no more than 6 days and always with food, otherwise nausea may occur. The preventative dose is 25-30 units. If discomfort arises, try the liquid form. Recently, I caught a cold with classic symptoms; my throat and nose were affected. I usually don’t recover in less than 5 days, but after 3 days of taking zinc and vitamins D and C, I felt revitalised!

Constipation details

Zinc may mitigate granisetron constipation

Nacci C, Fanelli M, Potenza MA, Leo V, Montagnani M, et al. Carbon monoxide contributes to the constipating effects of granisetron in rat colon. World J Gastroenterol. 2016;22:9333.

We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.

Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.

Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.

Constipation resolved

Most Useful Review

Zinc in capsules is of top quality with good ingredients, and I noticed health improvements. The dosage is reasonable, and I noticed immediate benefits, including improved digestion. My microbiome became noticeably better, and my intestines began to function well; constipation passed. It supports immunity, acidity, and overall effectiveness.

Liver Disease details

Chim SM, Howell K, Dronzek J, Wu W, Van Hout C, et al. Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings. Elife. 2024;12. doi:10.7554/eLife.90419

Zinc's Role in Liver Health

We focused on the connection between zinc and liver health, particularly how it may influence conditions like non-alcoholic fatty liver disease (NAFLD) and metabolic issues, including type II diabetes (T2D). Our analysis of data from a large genetics cohort revealed a significant finding: rare genetic variants that reduce the function of the zinc transporter SLC39A5 were linked to better metabolic profiles and lower T2D risk.

To delve deeper into these results, we used both laboratory and animal models. We developed mice that completely lacked SLC39A5 and observed promising outcomes. These mice showcased improved liver function and lower blood sugar levels after being subjected to obesity challenges, whether congenital or diet-induced.

Notably, this improvement seemed to be associated with increased levels of zinc in the liver, which activated key signaling pathways involved in metabolism, such as AMPK and AKT. Furthermore, these mice exhibited less liver inflammation and fibrosis in models of diet-induced non-alcoholic steatohepatitis (NASH).

Together, these findings position SLC39A5 as a potentially valuable target for treating liver-related metabolic disorders, emphasizing zinc's crucial role in managing liver health and blood sugar regulation.

7.5

Supports liver health

Most Useful Review

2 people found this helpful

To combat hair loss, I've started taking this zinc supplement, especially as my liver feels tired and I consume alcohol frequently. The small capsules are easy to take, and with just one capsule daily providing 50 mg of zinc, I'm hopeful it will support my liver health.

Heartburn details