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Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
125 mcg
625%
The product is found useful for the following medical conditions
Autoimmune Disorder
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Good
Based on 12 Reviews
8.7
9
Vitamin D3 modulates autoimmune response
Vitamin D3 attenuates autoimmune thyroiditis by regulating Th17/Treg cell differentiation via YAP/JAK1/STAT1 axis.
Most Relevant Research
We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
9.5
Immunity improvement
Most Useful Review
My immunity has improved significantly. I take this vitamin with meals, especially where fats are present. Doctors often recommend low doses, but I find 10,000 IU daily effective for my autoimmune disorder. My levels reached up to 100, and I seldom fall ill now. I will definitely purchase again.
Common Cold
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
USERS' SCORE
Good
Based on 20 Reviews
8.7
8
Vitamin D3 improves cold symptoms
Intake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study.
Most Relevant Research
We conducted a thorough investigation into how 25-hydroxyvitamin D3, commonly referred to as vitamin D3, impacts upper respiratory tract infections (URTIs), particularly the common cold. This study was carried out as a randomized, double-blind, placebo-controlled trial, engaging 428 participants, all aged between 45 and 74, across three clinics in Japan.
Participants were divided into two groups, with one receiving a daily dose of 10 μg of vitamin D3, while the other took a placebo for 16 weeks. Our findings highlighted that those who took vitamin D3 experienced a reduction in the duration of their upper respiratory symptoms, as well as a decrease in severity and improvement in their quality of life during illness.
Overall, our results indicate that supplementing with vitamin D3 might be a proactive step in handling the discomforts associated with common colds. This simple addition to one's daily routine could lead to a notably better experience when facing URTIs, providing a hopeful outlook for those looking for relief from their symptoms.
Participants were divided into two groups, with one receiving a daily dose of 10 μg of vitamin D3, while the other took a placebo for 16 weeks. Our findings highlighted that those who took vitamin D3 experienced a reduction in the duration of their upper respiratory symptoms, as well as a decrease in severity and improvement in their quality of life during illness.
Overall, our results indicate that supplementing with vitamin D3 might be a proactive step in handling the discomforts associated with common colds. This simple addition to one's daily routine could lead to a notably better experience when facing URTIs, providing a hopeful outlook for those looking for relief from their symptoms.
9.5
Effective for immunity
Most Useful Review
Finally, my immunity began to function properly! I recommend taking vitamin D with meals that contain fats. I've been able to treat my common cold more effectively since normalising my vitamin D levels; I caught a cold only once this past year and recovered in two days, compared to being ill five to six times a year previously. I will definitely purchase more.
Hypothyroidism
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.7
USERS' SCORE
Good
Based on 5 Reviews
8.7
9
Vitamin D3 reduces thyroid autoimmunity
A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis.
Most Relevant Research
We explored the potential effects of vitamin D3, or cholecalciferol, on individuals diagnosed with Hashimoto's thyroiditis, a common form of hypothyroidism characterized by autoimmune responses that damage thyroid cells. Our study was a carefully structured clinical trial conducted over one year, which included 100 patients suffering from both Hashimoto's thyroiditis and vitamin D deficiency.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
9.5
Increased energy
Most Useful Review
Excellent D3, preferable to other brands. I felt a surge of energy, particularly beneficial for my hypothyroidism. The quality and dosage are great if larger amounts are needed.
Anxiety
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.7
9
CYP11A1, Autism Symptoms, Vitamin D3
Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention.
Most Relevant Research
We explored how overexpression of the CYP11A1 enzyme in the placenta can impact offspring and potentially lead to autism-like behaviors, particularly focusing on anxiety. Using a specialized murine model, we looked closely at how this genetic change affected social interactions and anxiety levels in the mice.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
9.5
Energy restored
Most Useful Review
It turned my life around! I was experiencing severe brain fog, fatigue, and anxiety – issues I hadn't faced as an adult. A friend suggested I might have a Vitamin D deficiency given my symptoms. I bought these immediately, and the results are remarkable. The brain fog has lifted, anxiety and depression are no longer part of my life, and I have much more energy. These tiny vitamins have been a lifesaver, and I will definitely be ordering them again.
Cold Sores
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Effective for colds
Most Useful Review
I take it in large doses for 4-5 days during the treatment of colds and SARS. It always works!
Leg Cramps
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Effective relief
Most Useful Review
Good vitamin D3 for leg cramps, I took it two days prior and experienced no pain at all!
Pelvic Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Decreased anxiety
Most Useful Review
Great! My anxiety has reduced significantly, and I feel more confident and calm. My sleep is back to normal, allowing me to fall asleep easily and stay asleep. I no longer experience muscle spasms or aching legs due to the weather or overexertion. My blood pressure is normal, and I have far fewer headaches, which I believe is due to the magnesium addressing vascular spasms. I highly recommend it for anyone dealing with pelvic pain. The size and taste are pleasant, and the ingredients are natural and health-promoting.
Bloating
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 1 Review
8.6
9
Calcium D3 reduces bloating
Calcium vitamin D3 supplementation in clinical practice: side effect and satisfaction.
Most Relevant Research
We explored the effectiveness of OsteoCalVitFort, a supplement combining 500 mg of calcium and 400 IU of vitamin D3, focusing specifically on its impact on bloating. The study involved 186 participants aged 18 to 65 years, who took two tablets daily—one after breakfast and one after dinner.
Through follow-up phone calls, we gathered information about any side effects and the overall satisfaction with the supplement. Notably, we observed a significant reduction in bloating, with the rate decreasing from 12.5% before taking the supplement to just 0.6% after. This impressive drop highlights the potential benefits of vitamin D3 in alleviating bloating discomfort.
Overall, the findings suggest that OsteoCalVitFort is not only effective but also well-received by users, with 94% reporting satisfaction with their experience. Importantly, we noted that no significant adverse effects were reported, setting OsteoCalVitFort apart from other supplements often linked with gastrointestinal issues.
Through follow-up phone calls, we gathered information about any side effects and the overall satisfaction with the supplement. Notably, we observed a significant reduction in bloating, with the rate decreasing from 12.5% before taking the supplement to just 0.6% after. This impressive drop highlights the potential benefits of vitamin D3 in alleviating bloating discomfort.
Overall, the findings suggest that OsteoCalVitFort is not only effective but also well-received by users, with 94% reporting satisfaction with their experience. Importantly, we noted that no significant adverse effects were reported, setting OsteoCalVitFort apart from other supplements often linked with gastrointestinal issues.
10
No bloating reported
Most Useful Review
Great product, no stomach upset! I have had a problem digesting soy, causing intestinal cramping and bloating with most vitamin D supplements. I finished the entire bottle and experienced no side effects. I would greatly recommend it.
Cold
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin D3 aids cold recovery
Intake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study.
Most Relevant Research
We explored how 25-hydroxyvitamin D3 (25OHD), a form of vitamin D, influences upper respiratory tract infections (URTIs), commonly known as colds. In a carefully designed clinical study, we followed 428 participants aged 45 to 74 over a 16-week period. They were randomly assigned to receive either 10 μg of 25OHD daily or a placebo, all while maintaining a double-blind setup to ensure accurate results.
Our findings revealed that those who took 25OHD had reduced duration and severity of their cold symptoms. Participants reported improvements in their overall quality of life during the bouts of URTI. By tracking the health of the participants through surveys designed to measure cold symptoms, we gathered valuable data that indicates vitamin D3 could play a helpful role in managing colds.
This suggests that incorporating vitamin D3 into our diets may be beneficial when we catch a cold, potentially leading to a quicker recovery. It’s a promising avenue for anyone looking to ease the discomfort and duration of these frustrating infections.
Our findings revealed that those who took 25OHD had reduced duration and severity of their cold symptoms. Participants reported improvements in their overall quality of life during the bouts of URTI. By tracking the health of the participants through surveys designed to measure cold symptoms, we gathered valuable data that indicates vitamin D3 could play a helpful role in managing colds.
This suggests that incorporating vitamin D3 into our diets may be beneficial when we catch a cold, potentially leading to a quicker recovery. It’s a promising avenue for anyone looking to ease the discomfort and duration of these frustrating infections.
8.8
Boosts immune function
Most Useful Review
Crucial vitamin for bone health and immune function. Vitamin D3 is the most bioavailable form of vitamin D, renowned for its bone-protective properties. I take between 1000 - 5000 IU daily, varying by the season. When considering overdoses, the body can produce up to 20,000 IU after just 20 minutes of unprotected sun exposure in summer. Regular testing of vitamin D levels is wise for those on higher doses. Research shows a concerning deficiency in vitamin D, especially in winter, leading to increased risk of colds and respiratory infections. Vitamin D also encourages the production of cathelicidins that destroy viruses and boost resistance to colds. Throughout flu season, I find that vitamin D3 helps keep colds at bay, and since including this supplement in my routine along with vitamin C, I haven't experienced a cold since.
Flu
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin D3 reduces flu incidence
Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren.
Most Relevant Research
We carried out a study to investigate whether vitamin D3 supplements could help prevent seasonal influenza A in schoolchildren. Our approach involved a randomized, double-blind, placebo-controlled trial conducted from December 2008 to March 2009.
This ensured that neither the participants nor the researchers knew who was receiving the vitamin D3 or the placebo, making our findings more reliable. During the trial, we provided 1200 IU of vitamin D3 daily to one group while the other received a placebo.
The results were promising; we found that only 10.8% of the children taking vitamin D3 contracted influenza A, compared to 18.6% in the placebo group. This reduced incidence led us to a relative risk of 0.58, suggesting that vitamin D3 supplementation may lower the chances of getting the flu.
Interestingly, we noticed the most significant benefits among children who hadn’t been taking any other vitamin D supplements and those who began nursery school after age three. Additionally, in children with a past asthma diagnosis, vitamin D3 seemed to dramatically reduce asthma attacks.
Overall, our findings indicate that taking vitamin D3 in the winter could be beneficial for schoolchildren, especially for certain groups. We believe this study adds valuable insights into preventive health measures against influenza A.
This ensured that neither the participants nor the researchers knew who was receiving the vitamin D3 or the placebo, making our findings more reliable. During the trial, we provided 1200 IU of vitamin D3 daily to one group while the other received a placebo.
The results were promising; we found that only 10.8% of the children taking vitamin D3 contracted influenza A, compared to 18.6% in the placebo group. This reduced incidence led us to a relative risk of 0.58, suggesting that vitamin D3 supplementation may lower the chances of getting the flu.
Interestingly, we noticed the most significant benefits among children who hadn’t been taking any other vitamin D supplements and those who began nursery school after age three. Additionally, in children with a past asthma diagnosis, vitamin D3 seemed to dramatically reduce asthma attacks.
Overall, our findings indicate that taking vitamin D3 in the winter could be beneficial for schoolchildren, especially for certain groups. We believe this study adds valuable insights into preventive health measures against influenza A.
9.5
Prevents flu risks
Most Useful Review
Vitamin D3 is known for its bone protection and ability to enhance immune function. I trust this well-known brand for its quality. During flu season, D3 can prevent illness or shorten the duration of colds or flu. I've avoided them for years now by taking high doses of D3 when feeling ill, combined with vitamin C.
Osteoporosis
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.4
USERS' SCORE
Good
Based on 1 Review
8.6
9
Vitamin D derivatives enhance bone health
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities.
Most Relevant Research
We looked into the potential effects of vitamin D3, particularly its derivatives, on osteoporosis. Recent research highlights how modifications to the A-ring of 1α,25-dihydroxyvitamin D can enhance its binding to the vitamin D receptor. This change not only boosts the vitamin's effectiveness but also helps it resist breakdown in the body, making it stay active for longer periods.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
9.5
Effective combination
Most Useful Review
Life Extension was suggested by my doctor, who also offers complementary medicine. After a year of responsibly taking a combination of D3 and K2, my annual physical showed a healthy bone scan and proper calcium levels. At 60, with a family history of osteoporosis, D3 and K2 have changed my life. D3 helps absorb calcium, while K2 ensures it's delivered to my bones, not my arteries. It's essential to take them together for optimal results.
Bone Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 10 Reviews
8.5
7
Reduces inflammation
Most Useful Review
This product is excellent for my knee pain. It’s similar to taking anti-inflammatory medication like ibuprofen, with the same effect. Vitamin D can mitigate many inflammatory diseases, which I found crucial during my father’s hospitalisation.
Cardiovascular Disease
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.5
USERS' SCORE
Good
Based on 8 Reviews
8.5
8
Vitamin D improves heart disease factors
The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.
Most Relevant Research
We conducted a double-blind, randomized clinical trial to see how treating vitamin D deficiency could influence heart health, particularly in patients with ischemic heart disease (IHD). In our study, 44 IHD patients aged 40 to 65 were treated with either vitamin D or a placebo to assess changes in their lipid profiles and C-reactive protein (CRP) levels.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
9
Health improvement
Most Useful Review
Great Vitamin D with an effective dosage! My vitamin D levels have risen significantly. I take it along with vitamin K2 and calcium. Since starting this regimen, I've noticed fewer illnesses, which is crucial for my autoimmune condition. The jar also has a lovely design!
Chest Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 1 Review
8.5
8
Calcium and vitamin D3 treatment effective
ECG changes in a 25-year-old woman with hypocalcemia due to hypoparathyroidism. Hypocalcemia mimicking acute myocardial infarction.
Most Relevant Research
We explored the case of a 25-year-old woman who experienced chest pain and ECG changes typically associated with a heart attack. After undergoing cardiac catheterization, doctors found her coronary arteries to be normal but noted impaired left ventricular performance.
Further tests revealed she had primary hypoparathyroidism leading to low calcium levels, or hypocalcemia. To address this, she was treated with calcium and vitamin D3 supplements, which significantly improved her condition and alleviated her symptoms.
Although she eventually remained symptom-free, some ECG repolarization disturbances persisted. This case provides important insights into how low calcium levels can mimic acute myocardial infarction and highlights the effective role of vitamin D3 and calcium in alleviating related chest pain.
Further tests revealed she had primary hypoparathyroidism leading to low calcium levels, or hypocalcemia. To address this, she was treated with calcium and vitamin D3 supplements, which significantly improved her condition and alleviated her symptoms.
Although she eventually remained symptom-free, some ECG repolarization disturbances persisted. This case provides important insights into how low calcium levels can mimic acute myocardial infarction and highlights the effective role of vitamin D3 and calcium in alleviating related chest pain.
9
Back pain resolved
Most Useful Review
An excellent vitamin. My back pain has disappeared, and my efficiency has improved.
Pneumonia
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Effective treatment
Most Useful Review
My husband was ill with coronavirus and pneumonia, and his Vitamin D3 levels were low. We ordered this Vitamin 5000 and are very satisfied. We will later conduct tests to check the levels.
Cancer
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.5
8
Vitamin D3 offers anti-cancer benefits
Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth.
Most Relevant Research
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
8.8
Cancer risk reduction
Most Useful Review
Vitamin D3 is vital for bone health and immune function. This particular brand is well-regarded. Optimal Dosage varies, but I usually take between 1000 - 5000 IU. Vitamin D encourages the body to combat viruses and may decrease cancer risks. Deficiency leads to numerous health issues, particularly for older adults. With my daily routine, I haven't suffered from a cold or flu lately, showing its benefits.
Back Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 12 Reviews
8.4
9
Vitamin D3 improves back pain
Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial.
Most Relevant Research
We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
8.3
Less back pain
Most Useful Review
I take this vitamin D during winter, and I've experienced less back pain, reduced fatigue, and faster healing. It’s helped with hair loss and managing my weight as well.
Heart Disease
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.5
USERS' SCORE
Good
Based on 3 Reviews
8.2
8
Vitamin D improves heart health
The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.
Most Relevant Research
We conducted a double-blind, randomized clinical trial to explore how treating vitamin D deficiency affects heart health, specifically in patients with ischemic heart disease (IHD). In our study, we involved 44 patients aged between 40 and 65 who were dealing with low vitamin D levels. They were divided into two groups—one receiving vitamin D supplements and the other a placebo.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
7.5
Lower heart disease risk
Most Useful Review
Good composition. No vitamin enhances health like vitamin D (vitamin D3 or cholecalciferol). Research indicates that vitamin D may be vital in preventing SARS or upper respiratory infections. Studies show that higher vitamin D levels in blood are associated with a reduced risk of heart disease, breast cancer, and diabetes. I purchased vitamin D3 for the pandemic. The tablets are small and easy to swallow, ideally taken with fatty foods. I took a large dose of 5000 units.
Knee Pain
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7
USERS' SCORE
Good
Based on 7 Reviews
8.2
1
Vitamin D3 shows no benefit
Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial.
Most Relevant Research
We conducted a thorough investigation into the effects of vitamin D3 supplementation on knee pain and cartilage volume in people suffering from knee osteoarthritis, particularly those with low vitamin D levels. This study took place in Tasmania and Victoria, Australia, and was designed as a multicenter, randomized, double-blind, placebo-controlled clinical trial.
Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.
The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.
Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.
The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.
6.3
Knee pain management
Most Useful Review
This product is effective for my knee pain. It works similarly to anti-inflammatory drugs like ibuprofen. I witnessed its impact firsthand when my father took it in ICU, and it helped him recover. Vitamin D from any source is vital for all.
High Cholesterol
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
USERS' SCORE
Good
Based on 1 Review
8
9
Vitamin D3 lowers cholesterol levels
Vitamin D Supplementation Reduces Hyperlipidemia and Improves Bone Mass in Pediatric Obesity.
Most Relevant Research
We investigated how vitamin D3 supplements impact cholesterol levels in pediatric patients suffering from obesity. The study involved 723 children over two years, with 283 receiving vitamin D3 and 440 on a placebo.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
2.5
Ineffective treatment
Most Useful Review
Vitamin D levels remained low despite completing the entire course, leading to disappointment. My analysis showed low vitamin D, and it felt as though the supplement had no impact, unlike my friends who consumed liquid forms and had higher levels.
