NOW Supplements Omega 3-6-9

4 people found this helpful

It is the best value for money product. I have been taking it for nearly a year, and although the amount of EPA DHA per tablet is low, I take four tablets three times daily. My sinusitis, which troubled me for almost 20 years, has vanished. It is excellent for preventing inflammation.

Asthma details

Eicosapentaenoic acid improves asthma

Based on 24 Researches

Olave CJ, Ivester KM, Couetil LL, Burgess J, Park JH, et al. Effects of low-dust forages on dust exposure, airway cytology, and plasma omega-3 concentrations in Thoroughbred racehorses: A randomized clinical trial. J Vet Intern Med. 2023;37:338. doi:10.1111/jvim.16598

We compared how different types of forage affected asthma in Thoroughbred racehorses. Our focus was on assessing dust exposure, airway health, and the presence of eicosapentaenoic acid (EPA), an omega-3 fatty acid known for its anti-inflammatory properties. The horses were randomly assigned to three diets: dry hay, steamed hay, or haylage for a period of six weeks.

Throughout the study, we observed that horses fed steamed hay and haylage had significantly lower dust exposure compared to those that consumed dry hay. Interestingly, those on the haylage diet not only showed reduced levels of neutrophils in their bronchoalveolar lavage fluid, indicating better airway health, but they also had an increase in the ratio of anti-inflammatory to pro-inflammatory lipids, particularly EPA.

In fact, the horses on haylage had higher ratios of eicosapentaenoic acid compared to both their baseline measurements and horses on the other diets. This suggests that incorporating haylage could be beneficial for managing asthma symptoms in racehorses. Overall, it appears that haylage may help improve respiratory health by reducing inflammation linked to asthma through its higher anti-inflammatory lipid profile.

Effective asthma treatment

Most Useful Review

It helps with asthma very effectively, especially when taken with zinc and magnesium.

We explored how eicosapentaenoic acid (EPA) affects fibromyalgia, a complex pain condition characterized by widespread muscle pain, fatigue, and various psychological issues. To study this, we created a mouse model of fibromyalgia using intermittent cold stress and measured pain responses through a von Frey test. Our results showed a significant reduction in mechanical pain after administering EPA.

We observed that the administration of EPA not only alleviated mechanical pain but also helped in reducing thermal hyperalgesia, indicating a broader impact on pain sensitivity. Additionally, we discovered overexpression of proteins in the TRPV1 pain signaling pathway in different brain regions associated with pain perception, including areas like the thalamus and prefrontal cortex. Importantly, administering EPA significantly decreased this overactivity, suggesting a potential therapeutic effect.

Using a novel chemogenetics method, we inhibited certain brain regions to further understand the mechanism. The findings demonstrated an analgesic effect through the TRPV1 pathway, reinforcing the relevance of targeting this pathway for treating fibromyalgia. Overall, our study provides important insights about EPA as a possible treatment avenue for managing this challenging condition.

Cardiovascular benefits

Most Useful Review

Excellent product for those seeking good cardiovascular health. It aids in lowering cholesterol and alleviating signs of fibromyalgia.

Hot Flashes details

Effective Hot Flashes relief

Hot Flashes, anyone? Omega-3 is an excellent source of fish oil necessary for our health. I buy this Now product in bulk because it's effective for those pesky hot flashes. I took three capsules in the morning and three in the evening, and within a week, they completely disappeared! I've used this product for over five years with consistent results. I've tried various alternatives, but this is the only one that has worked. Whenever I stopped, I faced relentless hot flashes again, prompting me to return to Now's Omega-3. Experiment with your dosage, start with two, and gradually adjust as needed. It's a cost-effective alternative to doctors' prescriptions laden with side effects. Plus, it's heart-healthy. Best of luck!

Influenza details

Docosahexaenoic acid's antiviral effects

Based on 9 Researches

Lagarde M, Guichardant M, Bernoud-Hubac N. Anti-inflammatory and anti-virus potential of poxytrins, especially protectin DX. Biochimie. 2020;179:281. doi:10.1016/j.biochi.2020.09.008

We explored the potential of docosahexaenoic acid (DHA) and its derived compound, protectin DX (PDX), specifically in the context of influenza virus replication. The research highlights how poxytrins, which are dihydroxy derivatives formed from PUFA, may play a significant role in addressing inflammation and viral issues due to their unique structure.

Protectin DX is known for its ability to inhibit the activities of cyclooxygenase (COX), which are linked to inflammatory processes, as well as reducing the formation of harmful reactive oxygen species (ROS). Interestingly, we observed that PDX also has the potential to limit the replication of influenza viruses by interfering with their RNA metabolism.

While the study emphasizes this unique dual action, it should be noted that it primarily focuses on the effect of PDX alone, without comprehensive exploration of combined effects with other treatments. Regardless, the findings suggest a promising pathway for using DHA-derived compounds in viral mitigation, particularly relating to influenza.

Boosts vitality

Most Useful Review

An excellent supplement for the autumn-winter period during influenza and COVID-19. It definitely helps me get up more easily in the morning.

Ovarian Cancer details

Omega-3 acids are beneficial for the prevention of cancers such as colon, rectal, prostate, breast, and ovarian cancer. In postmenopausal women, regular consumption of fish oil has been associated with a 35% reduction in the risk of developing breast cancer. Additionally, Omega-3 polyunsaturated fatty acids serve as vital building blocks for tissues, aid in strengthening the immune system, and enhance overall brain function and metabolism.

Adrenal Gland Disorder details

Improved sleep quality

I really liked it; the quality is excellent, with the right halal ingredients and convenient packaging. This supplement has significantly improved my sleep, and I feel it benefits my adrenal glands. I ordered it again for myself and my children. Our health has noticeably improved; our nails and bones are stronger, hair is less brittle, and skin is healthier. The composition and ingredients are outstanding. We have ordered many times and take it continuously, boosting our immunity.

Anemia details

Wang H, Shi P, Huang C, Liu Q. Maresin 1 ameliorates iron-deficient anemia in IL-10(-/-) mice with spontaneous colitis by the inhibition of hepcidin expression though the IL-6/STAT3 pathway. Am J Transl Res. 2016;8:2758.

Based on 20 Researches

Maresin 1 helps treat anemia

We focused on how Maresin 1, a compound derived from docosahexaenoic acid, might help improve iron-deficient anemia in mice with chronic colitis. Our research involved IL-10 knockout mice, which are known to develop spontaneous colitis and associated anemia.

Over two weeks, we treated these mice with MaR1, observing several important changes. We found that MaR1 significantly reduced inflammation in the colon and was associated with a boost in hemoglobin levels, increased serum iron, and improved transferrin saturation.

Additionally, we noted that the levels of hepcidin, a protein that regulates iron metabolism and is often elevated during inflammation, decreased after treatment. This suggests that MaR1 helps combat anemia by influencing this protein's expression through the IL-6/STAT3 pathway.

Overall, we uncovered promising evidence that MaR1 has the potential to alleviate anemia connected to inflammatory processes, making it a noteworthy area for further exploration in treating patients with similar conditions.

Normalised anaemia levels

Most Useful Review

2 people found this helpful

I take one tablet each morning and evening. After six months of use, my anaemia has returned to normal. I'm combining this oil with multivitamins as recommended, and it seems to be working well.

Bruise details

4 people found this helpful

Hay fever has improved! Each spring, I experienced severe symptoms and often had bruises on my nose. Since I started taking this product, my hay fever symptoms have noticeably reduced.

Dizziness details

39 people found this helpful

I had coronavirus in June, which brought about dizziness and fatigue. I started taking Omega-3 and was pleasantly surprised by my improved health. I'm truly grateful for this product.

Hives details

Effective against hives

It worked for the hives I experienced every night.

Knee Pain details

Torres-Guzman AM, Morado-Urbina CE, Alvarado-Vazquez PA, Acosta-Gonzalez RI, Chávez-Piña AE, et al. Chronic oral or intraarticular administration of docosahexaenoic acid reduces nociception and knee edema and improves functional outcomes in a mouse model of Complete Freund's Adjuvant-induced knee arthritis. Arthritis Res Ther. 2014;16:R64. doi:10.1186/ar4502

Based on 18 Researches

DHA reduces knee pain and swelling

We explored whether purified docosahexaenoic acid (DHA), an omega-3 fatty acid, can ease knee pain and swelling in a mouse model of arthritis. Mice with arthritis were treated with either oral or injected DHA, and we observed notable improvements in pain behavior and knee swelling.

This study highlights that DHA may reduce pain and inflammation in knee arthritis, suggesting it could be a helpful option for those suffering from rheumatoid arthritis. However, it’s essential to keep in mind that these results come from an animal model, and human studies are necessary.

8.5

Back pain relief

Most Useful Review

90 people found this helpful

I’ve been taking this vitamin for a month now. My lower back pain from work has disappeared. The quality of life is worth the money.

Osteoporosis details

Li L, Wen Y, Liu D, Lan JP, Yang B. Causal link between docosahexaenoic acid and osteoporosis: A 2-sample Mendelian randomization study. Medicine (Baltimore). 2024;103:e38893. doi:10.1097/MD.0000000000038893

Based on 35 Researches

DHA linked to osteoporosis risk

We examined the relationship between docosahexaenoic acid (DHA) and osteoporosis using a method called 2-sample Mendelian randomization. This approach allowed us to investigate if higher levels of DHA could be a risk factor for osteoporosis.

Our findings revealed a causal tie: increased blood levels of DHA were indeed linked to a higher risk of developing osteoporosis. Specifically, for each standard deviation increase in DHA levels, the risk for osteoporosis rose by nearly 10%. We found this connection to be statistically significant, with a P-value of 0.033.

However, it's important to point out that the genetic correlation between DHA and osteoporosis was weak, suggesting that this relationship might not be heavily influenced by our genes. While these results indicate that DHA levels are a risk factor for osteoporosis, the underlying mechanisms are still unclear, highlighting the need for further research in this area.

Similar to others

Most Useful Review

Omega-3 fatty acids prevent osteoporosis, maintain joint health, and lessen pain during flare-ups. They combat bone loss and relieve inflammation, helping with rheumatoid arthritis and cartilage issues.

Psoriasis details

Morin S, Tremblay A, Dumais E, Julien P, Flamand N, et al. Eicosapentaenoic Acid Influences the Lipid Profile of an In Vitro Psoriatic Skin Model Produced with T Cells. Biomolecules. 2023;13. doi:10.3390/biom13091413

Based on 26 Researches

EPA benefits psoriatic skin health

We aimed to understand how eicosapentaenoic acid (EPA) affects psoriasis, a skin condition known for causing redness, irritation, and thickened skin. By creating skin models that reflect both healthy and psoriatic conditions, we were able to assess the impact of EPA directly on lipid profiles—a key factor in skin health.

Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.

More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.

Smoother skin

Most Useful Review

I tried this Omega for the first time and noticed results in just ten days. Previously, I used a Russian brand that was ineffective. My psoriasis has improved; the skin on my hands is smoother, and the cracks are healing. I’ve purchased a large jar since the quality is excellent, and my mother, who is hypertensive, found it beneficial too.

Sleep Apnea details

Yokoi-Shimizu K, Yanagimoto K, Hayamizu K. Effect of Docosahexaenoic Acid and Eicosapentaenoic Acid Supplementation on Sleep Quality in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial. Nutrients. 2022;14. doi:10.3390/nu14194136

Moderately Effective

Based on 2 Researches

Omega-3s enhance sleep quality

We investigated how omega-3 fatty acids, specifically DHA and EPA, affect sleep quality in adults aged 45 and older. Our study involved 66 healthy participants and employed a randomized, double-blind, placebo-controlled design for 12 weeks.

Participants in the DHA/EPA group showed significant improvements in sleep quality metrics, including less frequent dreaming and better sleep efficiency compared to those taking a placebo. This is notable as it provides new insights about the beneficial effects of omega-3s on sleep in an older demographic.

Brain relaxation

Most Useful Review

Magnesium glycinate is very beneficial for my brain's rest during sleep, restoring my memory. It is suitable for all ages, and I believe it’s essential since our bodies do not produce or store it.

Whooping Cough details

I was advised to take Omega 3 during my cold, which seems effective against whooping cough. It really works for me!

Alzheimer details

Otaegui L, Urgin T, Zaiter T, Zussy C, Vitalis M, et al. Nose-to-brain delivery of DHA-loaded nanoemulsions: A promising approach against Alzheimer's disease. Int J Pharm. 2025;670:125125. doi:10.1016/j.ijpharm.2024.125125

Based on 29 Researches

DHA shows promise in Alzheimer's

We investigated the potential benefits of docosahexaenoic acid (DHA) in fighting Alzheimer's disease (AD) through a novel intranasal administration method. By using a specially formulated nanoemulsion that protects DHA from oxidation, we aimed to enhance its delivery to the brain. In our study, we administered this DHA-rich nanoemulsion to J20 mice, a well-known transgenic model for AD.

The results were promising. After treatment, the mice showed notable improvements in their well-being and memory performance, which we measured through their ability to navigate spatial tasks. Additionally, we observed a significant reduction in harmful amyloid deposits, oxidative stress, and neuroinflammation within their brain tissues. This positive outcome could potentially stem from DHA's ability to affect specific processes in the brain, such as the inactivation of GSK3β, a kinase associated with AD.

Overall, our findings suggest that intranasal DHA treatment not only has therapeutic effects but may also modify the progression of Alzheimer's disease. Considering that DHA has already demonstrated safety in humans, we believe there is a strong case for conducting clinical trials to explore this approach further for Alzheimer's patients.

Alzheimer prevention

Most Useful Review

1 people found this helpful

The quality is superb. Omega-3 PUFAs provide energy for signalling between neurons, enhancing memory and attention. A deficiency impairs these functions. Studies show Omega-3 reduces the risk of Alzheimer’s and slows cognitive decline, especially in patients who start supplementation early.

Back Pain details

Eicosapentaenoic acid alleviates back pain

Based on 9 Researches

Lin Z, Ni L, Teng C, Zhang Z, Wu L, et al. Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis. Front Cell Dev Biol. 2021;9:745621. doi:10.3389/fcell.2021.745621

We explored how eicosapentaenoic acid (EPA) might help in treating intervertebral disc degeneration (IDD), a major contributor to back pain. Research highlights that this condition often involves endoplasmic reticulum (ER) stress and breakdown of the extracellular matrix (ECM), key processes that worsen IDD. Our investigation demonstrated that EPA can promote autophagy, a process that helps cells clean up and maintain balance within the ECM.

Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.

In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.

Eased back pain

Most Useful Review

96 people found this helpful

This vitamin is the best I have tried. As a chronic pain sufferer, I'm always looking for supplements to help. This one gives me an energy boost, and I am experiencing less back pain after taking it.

Candidiasis details

Effective cold relief

The packaging is handy, and the capsules are medium-sized and easy to swallow. Although there is only one ingredient, its effectiveness is remarkable! I noticed benefits within a week. My cold disappeared in just two days after I started taking three capsules daily along with a zinc tablet. Additionally, as mentioned, the symptoms of Candidiasis have vanished, which is quite delightful! I appreciate the quality. This product is excellent for cold prevention!

Chronic Fatigue Syndrome details

Eicosapentaenoic acid shows potential

Based on 5 Researches

Puri BK. The use of eicosapentaenoic acid in the treatment of chronic fatigue syndrome. Prostaglandins Leukot Essent Fatty Acids. 2004;70:399.

We assessed how eicosapentaenoic acid, an essential fatty acid, impacts chronic fatigue syndrome (CFS). A group of CFS patients took a specific supplement rich in this fatty acid. Remarkably, every participant reported symptom improvement within eight to twelve weeks.

These findings align with other research that shows the positive effects of eicosapentaenoic acid, hinting that it could be a promising treatment option for some individuals living with CFS.

Increased energy

Most Useful Review

423 people found this helpful

I have been taking omega for three months now. Initially drawn by the price and dosage of DHA and EPC, I've found my skin to be much softer without any cosmetic procedures. I take one capsule daily in the morning and evening, alongside vitamin D3. My husband's chronic fatigue syndrome symptoms have improved, including the disappearance of bruises under his eyes and a noticeable increase in energy and mood. I highly recommend it!

Hypothyroidism details

Abd Allah ES, Gomaa AM, Sayed MM. The effect of omega-3 on cognition in hypothyroid adult male rats. Acta Physiol Hung. 2014;101:362. doi:10.1556/APhysiol.101.2014.3.11

Based on 9 Researches

Omega-3 benefits in hypothyroidism

We set out to explore how hypothyroidism affects cognitive functions in adult male rats and whether omega-3 supplementation could help. In our study, we divided thirty rats into three groups: a control group, one with induced hypothyroidism, and another that received omega-3 treatment.

The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.

Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.

Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.

Improved well-being

Most Useful Review

Chewable tablets are delightful! I have hypothyroidism and high homocysteine. I take this B12 alongside other supplements, and after a month, I feel fantastic! The dosage is optimal, replenishing my deficiency while reducing homocysteine. I regularly remember to take it because they taste good, and B12 is better absorbed sublingually through the oral mucosa. A great addition!

Migraine details

EPA significantly reduces migraine frequency

Based on 23 Researches

Wang HF, Liu WC, Zailani H, Yang CC, Chen TB, et al. A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine. Brain Behav Immun. 2024;118:459. doi:10.1016/j.bbi.2024.03.019

We conducted a 12-week randomized, double-blind clinical trial to evaluate the effects of eicosapentaenoic acid (EPA) on episodic migraine. Seventy participants were divided into two groups, one receiving EPA-rich fish oil and the other a placebo.

Results showed that individuals taking EPA experienced a significant decrease in migraine frequency and severity compared to the placebo group. This included fewer migraine days and improved psychological well-being.

Notably, women appeared to benefit the most, highlighting EPA's potential as a promising preventive treatment for migraine.

Migraine prevention

Most Useful Review

32 people found this helpful

"Mega" omega! This fish oil supplement contains polyunsaturated fatty acids like EPA and DHA, which significantly lower cholesterol and help prevent cardiovascular diseases. Omega-3 is effective for various conditions, including skin diseases and gastric ulcers. It also benefits brain function and helps reduce migraine symptoms. After starting the capsules, I noticed improvements in my migraines and overall health. I take three capsules daily with meals. If my review is helpful, please click "YES" below and check my other reviews. Wishing you good health!

Rosacea details

Omega 3 fish oil has been the best product I've used, delivering beautiful results from the start. It effectively calms my very dry skin affected by rosacea and sensitivity. The texture is quite heavy, so I only apply a small amount to specific areas. The luxurious packaging, complete with a spoon, adds to the experience. Suitable for all ages, it boasts high quality and numerous benefits. Its size and design are also impressive.

Tinnitus details

I constantly take these marvellous capsules and enjoy good health; my tinnitus has disappeared and shortness of breath has lessened.

Blurred Vision details

51 people found this helpful

Excellent! An effective supplement with an unexpectedly impressive composition. It benefits vision and improves sperm health. Omega is highly beneficial and should be continued, especially as a preventive measure. Following this supplement, I’ve experienced significant improvements in inflammation and blood vessel constriction. A remarkable result, I truly recommend it! I opted for a package of 200 tablets, supplying 180 EPA and 120 DHA. I wish to clarify some myths surrounding omega-3 capsules—regardless of the manufacturer, they aren’t a cure-all solution. However, the effects have been notably positive after three weeks of consistent use.

Bone Pain details

Resolvin D1 alleviates bone cancer pain

Likely Very Effective

Flippen A, Khasabova IA, Simone DA, Khasabov SG. Systemic administration of Resolvin D1 reduces cancer-induced bone pain in mice: Lack of sex dependency in pain development and analgesia. Cancer Med. 2024;13:e70077. doi:10.1002/cam4.70077

We explored the potential of Resolvin D1 (RvD1) as a non-opioid treatment for bone cancer pain in a mouse model. RvD1 was administered intravenously, showing a remarkable ability to lessen pain effects similarly in both male and female mice.

We found that a single dose effectively reduced pain, while daily treatments eliminated it entirely. Notably, sex didn't influence the pain or treatment efficacy, opening doors for RvD1 as a viable alternative to opioids in managing bone cancer pain.

Improved well-being

Most Useful Review

100 people found this helpful

Wonderful! I've been taking this vitamin for about a month, and I've noticed a significant difference in my mood and energy. My bone pain was quite severe, but since starting this supplement, my quality of life has greatly improved.

Menopause details

Gao H, Ying Y, Sun J, Huang Y, Li X, et al. Genetically Determined Plasma Docosahexaenoic Acid Showed a Causal Association with Female Reproductive Longevity-Related Phenotype: A Mendelian Randomization Study. Nutrients. 2024;16. doi:10.3390/nu16234103

Based on 31 Researches

Omega-3 links to menopause timing

We investigated the link between omega-3 fatty acids and the timing of menopause. Using a Mendelian randomization approach, we analyzed data from thousands of women to assess how different fatty acids influenced reproductive longevity—specifically, the age at menopause.

Our findings revealed that higher plasma levels of DHA, a type of omega-3, were associated with a delayed onset of menopause. This suggests that increasing DHA could be a potential strategy for extending women's reproductive lifespan.

Enhances health during menopause

Most Useful Review

These capsules are excellent and have made a noticeable difference in how I feel during menopause. My nails, skin, and hair have improved. I recommend purchasing them!

Mild Cognitive Impairment details

Positive effects noted

Since taking Cospa, I've felt a positive impact, especially when I feel unwell. It has a smooth effect and also helps prevent Mild Cognitive Impairment. The size is large but easily swallowable, which I appreciate.

Multiple Sclerosis details

Eicosapentaenoic acid reduces MS symptoms

Based on 25 Researches

Unoda K, Doi Y, Nakajima H, Yamane K, Hosokawa T, et al. Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis. J Neuroimmunol. 2013;256:7. doi:10.1016/j.jneuroim.2012.12.003

We explored the therapeutic effects of eicosapentaenoic acid (EPA) in tackling multiple sclerosis through a study involving mice with experimental autoimmune encephalomyelitis (EAE). The mice were given diets enriched with or without EPA. Remarkably, the mice that received the EPA-infused diet displayed significantly lower clinical scores compared to those that did not.

Furthermore, we observed that the production of inflammatory markers like IFN-γ and IL-17 was notably reduced in the EPA-treated mice. This reduction is particularly important, as these markers are associated with the progression of multiple sclerosis. Additionally, there was an enhancement in the expression levels of peroxisome proliferator-activated receptors within the CD4T cells infiltrating the central nervous system.

These findings suggest that EPA could serve as a promising new approach to therapy for multiple sclerosis, showcasing its potential in reducing inflammation and improving clinical outcomes in those affected by this condition.

Excellent quality

Most Useful Review

1 people found this helpful

I've been using this for many years without interruption, despite having multiple sclerosis. The quality is excellent and unmatched by any competitor.

Pneumonia details

Recovered from pneumonia

In today’s climate, Omega-3 is a must-have! I regularly take it for my family. It greatly assisted my mother-in-law in recovering from severe pneumonia and helps maintain our overall health. I highly recommend it!

Premenstrual Syndrome details

4 people found this helpful

This Omega-3 product, recommended by my trainer for lipid metabolism, has amazed me. After taking four capsules daily for a month, I experienced a painless menstrual cycle without needing any pain relief medication for the first time. I'm very pleased and have ordered it again.

Acanthosis Nigricans details

Good omega, prescribed by the gynaecologist for inflammation. It has effectively assisted with treating acanthosis nigricans during systemic treatment.

Anxiety details

Omega-3s improve mental health outcomes

Based on 26 Researches

Li Y, Hua L, Ran Q, Gu J, Bao Y, et al. Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults. Nutrients. 2024;16. doi:10.3390/nu16234065

We explored the impact of polyunsaturated fatty acids (PUFAs), particularly omega-3s, on anxiety and depression in over 102,000 participants from the UK Biobank.

The study revealed that higher levels of omega-3 PUFAs were linked to lower risks of developing anxiety and depressive disorders, alongside improvement in adverse psychological symptoms.

Additionally, the research highlighted significant associations between these fatty acids and brain white matter structure, providing valuable insights into how omega-3s might support mental wellness.

Relief from anxiety

Most Useful Review

96 people found this helpful

Прекрасно! When I began taking this vitamin, I experienced a sensation of relief as my stress and anxiety seemed to fade. It helps me feel more grounded and calm. I cannot imagine living without this vitamin.

Arteriosclerosis details

Chong SY, Wang X, van Bloois L, Huang C, Syeda NS, et al. Injectable liposomal docosahexaenoic acid alleviates atherosclerosis progression and enhances plaque stability. J Control Release. 2023;360:344. doi:10.1016/j.jconrel.2023.06.035

Based on 25 Researches

DHA stabilizes arterial plaques

We embarked on a quest to understand how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, can impact atherosclerosis, a condition where fatty deposits clog the arteries. Our focus was on a specially developed injectable formulation that delivers DHA directly to the site of arterial plaques.

Through our research, we discovered that this liposomal DHA formulation not only protects the compound but also enhances its effectiveness. When we administered it intravenously, DHA particles were specifically absorbed by macrophages—immune cells involved in the inflammation seen in atherosclerosis. This targeted delivery helps reduce inflammation and prevents the formation of foam cells, which are a hallmark of atherosclerotic plaques.

Furthermore, our analysis of the plaques revealed that the DHA treatment led to less macrophage infiltration and reduced lipid build-up, which improves overall plaque stability. In simpler terms, we observed that the treatment makes plaques less likely to rupture, which is critical in preventing serious cardiovascular problems. Additionally, sophisticated imaging techniques showed that DHA can help restore some of the healthy lipid profiles typical of earlier stages of plaque development.

In summary, using injectable DHA offers exciting potential for stabilizing arterial plaques and slowing down the progression of atherosclerosis. Given the importance of addressing this condition, our findings could pave the way for new therapeutic strategies to reduce the risk of heart-related issues.

7.5

Improved circulation

Most Useful Review

5 people found this helpful

Omega-3 is excellent for managing triglycerides and arteriosclerosis. Since starting to take fish-derived DHA and EPA oils, my triglyceride levels returned to normal. It appears that high omega-3 fatty acid levels in red blood cells can improve flexibility and blood circulation, which may help prevent arteriosclerosis.

Atrial Flutter details

3 people found this helpful

I suffered from cardiac arrhythmia, but after taking omega-3, it vanished. Although I occasionally burp fish, I believe this is normal. The crucial aspect is that it eliminated my arrhythmias completely.

Common Cold details

Imhoff-Kunsch B, Stein AD, Martorell R, Parra-Cabrera S, Romieu I, et al. Prenatal docosahexaenoic acid supplementation and infant morbidity: randomized controlled trial. Pediatrics. 2011;128:e505. doi:10.1542/peds.2010-1386

Based on 3 Researches

DHA reduces infant cold symptoms

We conducted a double-blind randomized controlled trial to understand how prenatal supplementation of docosahexaenoic acid (DHA) might influence infant health, particularly concerning the common cold. Pregnant women were given either a daily dose of 400 mg of DHA or a placebo starting at 18 to 22 weeks of gestation until childbirth.

Caregivers then reported on their infants’ health at 1, 3, and 6 months, sharing details about common illness symptoms. We found that DHA supplementation appeared to reduce the number of colds at one month and also seemed to lessen the duration of various cold symptoms in infants. Specifically, infants in the DHA group experienced fewer cold symptoms and had shorter durations of cough and wheezing.

While the overall occurrence of specific illness symptoms was similar between the DHA and placebo groups, DHA did bring about noteworthy benefits. At 1 month, infants in the DHA group had a 26% shorter duration of cough and 30% shorter wheezing; however, they experienced a longer duration of rash.

Furthermore, by the time the infants reached 3 months, those whose mothers took DHA were ill for 14% less time overall. At 6 months, the DHA group showed significantly reduced durations of several illness indicators, although they did experience longer episodes of vomiting.

This study suggests that prenatal DHA not only seems to impact the occurrence of colds in children but may also play a role in the duration of symptoms over the first half-year of life.

Prevents illness

Most Useful Review

131 people found this helpful

I've been taking Omega-3 daily for four months, and I haven't caught a common cold. I experienced outbreaks of herpes after a two-month break, so I'll resume taking it. If my review helped you, please like it.

Headache details

EPA shows promise for migraine relief

Based on 20 Researches

We examined the effects of eicosapentaenoic acid (EPA) on episodic migraine patients through a 12-week randomized double-blind trial. Seventy participants were divided into two groups, one receiving EPA and the other a placebo.

Those taking the EPA experienced significant decreases in migraine frequency, medication use, headache severity, and improvements in overall quality of life.

Notably, women benefitted particularly from this treatment. Overall, high-dose EPA showed promise as an effective preventive option for episodic migraines, with no major side effects observed.

No more headaches

Most Useful Review

220 people found this helpful

Excellent Omega-3 from NOW! Good composition and great price. We take it with multivitamins and vitamin D3 in the morning. After two weeks, the headaches disappeared, and we feel more energetic. My skin improved, and my hair, which was falling out, is now shiny and healthy. I highly recommend it!

Heart Attack details

Omega-3s' mixed effects on heart health

Based on 37 Researches

Rodriguez D, Lavie CJ, Elagizi A, Milani RV. Update on Omega-3 Polyunsaturated Fatty Acids on Cardiovascular Health. Nutrients. 2022;14. doi:10.3390/nu14235146

We examined the impact of omega-3 fatty acids, often found in fish oil, on heart attack risks, particularly in patients with high triglyceride levels. The studies indicate that while omega-3s can effectively lower triglycerides and reduce certain cardiovascular disease outcomes, including fatal heart attacks, their overall benefit remains debated. Despite extensive research demonstrating some positive outcomes, many experts still question the magnitude of their effects on heart attack prevention. Improved guidance on omega-3 supplementation is still evolving as new evidence emerges.

Heart attack prevention

Most Useful Review

1875 people found this helpful

I drink Omega-3 with lecithin, and it has significantly improved my heart health and sleep quality. At my age, staying well is crucial. My family has long-lived members, and I intend to live longer for my grandchildren. I highly recommend Omega-3!

Hemorrhoids details

I always buy this product as it helps with my hemorrhoids, and it benefits my libido.

Liver Disease details

Zhang H, Lu Y, Zhang Y, Dong J, Jiang S, et al. DHA-enriched phosphatidylserine ameliorates cyclophosphamide-induced liver injury via regulating the gut-liver axis. Int Immunopharmacol. 2024;140:112895. doi:10.1016/j.intimp.2024.112895

DHA-PS promotes liver recovery

We investigated the potential of DHA-enriched phosphatidylserine (DHA-PS) in addressing liver injuries caused by cyclophosphamide in mice. By administering cyclophosphamide over five days, we created a model to simulate this liver damage. Following this, we treated the mice with different doses of DHA-PS for a week to see if it could help heal their livers.

Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.

Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.

Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.

7.5

Cholesterol benefits

Most Useful Review

207 people found this helpful

The quality is excellent with no age restrictions. The packaging is impressive, and the benefits for women's health are significant! My hair condition has improved markedly. Omega 3 fish oil is essential for women, as it reduces cholesterol and alleviates inflammation. Though I find the taste bland, its importance for health cannot be overstated, and I recommend it for those with heart disease.

Obesity details

Eicosapentaenoic Acid Reduces Obesity

Based on 25 Researches

Smorenburg JN, Hodun K, McTavish PV, Wang C, Pinheiro MA, et al. EPA/DHA but Not ALA Reduces Visceral Adiposity and Adipocyte Size in High Fat Diet-Induced Obese Delta-6 Desaturase Knockout Mice. Mol Nutr Food Res. 2025;69:e202400721. doi:10.1002/mnfr.202400721

In our exploration of omega-3 fatty acids, we aimed to understand how eicosapentaenoic acid (EPA), compared to α-linolenic acid (ALA), impacts obesity, particularly in a specific mouse model designed for this purpose. We fed both wildtype and delta-6 desaturase knockout (KO) mice a high-fat diet rich in different fats over a period of 21 weeks. These diets included lard, which contains no omega-3s, flaxseed (rich in ALA), and menhaden fish oil (rich in EPA and docosahexaenoic acid, DHA).

What we found was quite revealing. While the final body weights of the mice did not vary significantly, those fed menhaden oil experienced reduced epididymal white adipose tissue (eWAT) weight, smaller adipocyte sizes, and lower triacylglycerol (TAG) content compared to those on a lard diet. Interestingly, the eWAT of flaxseed-fed wildtype mice showed similar improvements as those on menhaden oil, but this positive effect did not extend to the KO mice, which exhibited characteristics more similar to the lard group.

It's important to note that despite these differences in adipose characteristics, we did not observe any changes in inflammatory markers between the different groups. This suggests that while a diet enriched in EPA/DHA may help reduce fat storage and cell size, it does not appear to influence inflammatory responses in this particular model of obesity. Overall, this study highlights the specific benefits of EPA/DHA in addressing obesity-related issues without exacerbating inflammation.

Skin improvement

Most Useful Review

I found this omega-3 to be delightful with no off-putting smells. After a monthly course, my skin improved significantly, and it effectively lowers the risk of cardiovascular diseases and obesity. I recommend it highly!

Prostate Cancer details

Eicosapentaenoic acid's anti-cancer effects

Oono K, Ohtake K, Watanabe C, Shiba S, Sekiya T, et al. Contribution of Pyk2 pathway and reactive oxygen species (ROS) to the anti-cancer effects of eicosapentaenoic acid (EPA) in PC3 prostate cancer cells. Lipids Health Dis. 2020;19:15. doi:10.1186/s12944-019-1122-4

We investigated how eicosapentaenoic acid (EPA) influences prostate cancer cells, particularly focusing on its effects on PC3 prostate cancer cells. To understand this, we treated the cells with various concentrations of EPA and monitored their survival, migration, and invasion abilities over time.

Our findings revealed that EPA reduces the survival rate of PC3 cells in a dose-dependent manner, showing significant effectiveness at a concentration of 500 μmol/L within just three hours of treatment. Moreover, we observed that EPA inhibits key cellular pathways linked to cancer cell growth, particularly the phosphorylation of a protein known as Pyk2. Interestingly, even though EPA affected Pyk2, this action occurred independently of reactive oxygen species (ROS) production, while growth inhibition appeared to depend significantly on the induction of ROS.

Overall, our research highlighted how the combined inhibition of Pyk2 and ROS contribute to the anti-cancer properties of EPA. This suggests that EPA could be a valuable component in therapeutic strategies for combating prostate cancer.

7.5

Effective Omega supplement

Most Useful Review

I have been taking NOW Brand Omega 3-6-9 for 18 years, but due to being prescribed Tamoxifen after breast cancer, I had to stop all but Omega 3. I switched to these capsules, and they are nearly as good as the 3-6-9 blend. I plan to return to the 3-6-9 once I finish Tamoxifen.

Stroke details

Omega-3s reduce ischemic stroke risk

Based on 27 Researches

O'Keefe JH, Tintle NL, Harris WS, O'Keefe EL, Sala-Vila A, et al. Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies. Stroke. 2024;55:50. doi:10.1161/STROKEAHA.123.044281

We dove into the connection between omega-3 fatty acids and stroke risks by analyzing data from 29 global cohorts, involving over 183,000 participants.

Our findings revealed that higher levels of omega-3s, particularly eicosapentaenoic acid and docosahexaenoic acid, are linked to a reduced risk of total and ischemic strokes. Specifically, those with the highest omega-3 levels experienced a 17% lower incidence of total stroke and an 18% reduced risk of ischemic stroke.

However, it's important to note that omega-3 levels showed no impact on hemorrhagic stroke risk.

Vessel strengthening

Most Useful Review

1 people found this helpful

Omega-3 is essential for maintaining elastic blood vessels and preventing health issues like strokes and heart attacks. After experiencing nosebleeds and other symptoms, my doctor advised Omega-3. After a month, my symptoms improved significantly. I will continue to use it and recommend it, especially to women over 50.

Abscess details

6 people found this helpful

A wonderful product. I experienced real and noticeable results, as the cysts in my ovaries have vanished.

Adenoiditis details

Improved digestion noted

72 people found this helpful

My husband and I initially struggled but soon observed better digestion and increased energy after a week of taking this Omega-3. The capsules are large, yet I adapted to taking them with meals without discomfort. I appreciate that our fussy cat also enjoys them, indicating their natural quality. We noted enhanced well-being and plan to order more.

Allergies details

Hirakata T, Lee HC, Ohba M, Saeki K, Okuno T, et al. Dietary ω-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating T2 immune responses. FASEB J. 2019;33:3392. doi:10.1096/fj.201801805R

Based on 37 Researches

Omega-3s reduce allergic symptoms

We discovered that a diet enriched with omega-3 fatty acids can effectively reduce symptoms of allergic conjunctivitis (AC) in mice. This reduction occurred without influencing the typical immune responses usually associated with allergies. Instead, omega-3s worked by changing the lipid molecules linked to inflammation.

Notably, these fatty acids completely suppressed itching near the eyes and significantly decreased the presence of eosinophils, cells commonly involved in allergic reactions. However, total serum IgE levels and T2 cytokine expression remained unchanged, suggesting that omega-3s tackle AC symptoms in a unique way.

Preventing allergies

Most Useful Review

122 people found this helpful

Omega-3 is vital for health, especially to prevent allergies and cardiovascular diseases. These acids are crucial as a deficiency can lead to serious health issues. The product contains effective doses of DHA and EPA, essential for overall well-being. Given their importance, I take these regularly and have observed positive health improvements.

Breast Cancer details

Maralbashi S, Aslan C, Kahroba H, Asadi M, Soltani-Zangbar MS, et al. Docosahexaenoic acid (DHA) impairs hypoxia-induced cellular and exosomal overexpression of immune-checkpoints and immunomodulatory molecules in different subtypes of breast cancer cells. BMC Nutr. 2024;10:41. doi:10.1186/s40795-024-00844-y

DHA impacts breast cancer immunity

We explored the role of docosahexaenoic acid (DHA), an omega-3 fatty acid, in altering the behavior of breast cancer cells, specifically focusing on how it impacts immune responses. Cancer cells often use immune-checkpoint molecules to evade our body’s natural defenses, and this study looked at whether DHA could influence the expression of these critical molecules.

By treating two types of breast cancer cells—MDA-MB-231 (triple negative) and BT-474 (triple positive)—with DHA under both normoxic and hypoxic (low oxygen) conditions for 24 hours, we observed notable changes. The study showed that hypoxia caused a significant increase in immune-checkpoints and immunomodulatory molecules. However, when we introduced DHA, the results were promising: there was a marked decrease in the expression of those immune markers.

Additionally, the treatment with DHA also led to an increase in regulatory microRNAs, which are important for controlling the immune response. These results suggest that DHA might play a supportive role in breast cancer therapy by reducing the mechanisms that allow cancer cells to escape immune surveillance. This could open pathways for new treatment options that integrate nutritional interventions like DHA supplementation alongside traditional cancer therapies.

7.5

Helps breast cancer prevention

Most Useful Review

The quality is beautiful, and the Omega-3 ingredients are beneficial. Omega-3 fatty acids, especially DHA, are crucial for health, maintaining brain health, protecting the retina, and enhancing heart health by lowering triglycerides. Studies confirm that Omega-3s may lower the risk of breast cancer and high blood pressure, among other conditions. The taste is normal.

Eczema details

Eicosapentaenoic Acid reduces eczema

Based on 20 Researches

USERS' SCORE

Good

Based on 14 Reviews

Mirrahimi B, Moazemi M, Eslami N, Jamshidi E, Mir M, et al. Evaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial. J Pediatr Pharmacol Ther. 2023;28:29. doi:10.5863/1551-6776-28.1.29

We embarked on a study to find out how dietary eicosapentaenoic acid (EPA) could help children suffering from atopic dermatitis, a common form of eczema. In a randomized triple-blind clinical trial, 48 children with this condition were divided into two groups—one received 250 mg of EPA twice daily, while the other received a placebo for four weeks.

Our observations showed noticeable improvements in those who took EPA. After just two weeks, participants in the EPA group reported a reduction in their SCORAD scores, which are used to measure the severity of atopic dermatitis. The scores went down significantly compared to the placebo group. After four weeks, the number of children needing corticosteroids to manage their symptoms was also lower in the EPA group.

Despite these positive results, both groups reported few adverse effects, indicating that EPA supplementation is generally well-received. Overall, we conclude that adding EPA to the diet may be an effective and safe strategy for reducing eczema severity in children.

7.5

Eczema management

Most Useful Review

19 people found this helpful

My skin is fragile due to weak intestines, leading to issues like acne and eczema. Combining it with NOW Vitamin C and pantothenic acid has helped significantly since I began taking it. Previously, I struggled with eczema around my hands, which has improved notably. I appreciate Omega-3 and consider it essential for my well-being, especially in managing eczema.

Heart Disease details

Jawad MA, O'Keefe JH, Tintle N, O'Keefe EL, Franco WG, et al. Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities. Mayo Clin Proc. 2024;99:1895. doi:10.1016/j.mayocp.2024.08.007

Omega-3 reduces heart disease risk

We examined the relationship between plasma omega-3 levels and heart failure (HF), focusing on how this affects mortality in patients with existing HF. Our analysis of the UK Biobank, which included nearly 272,000 participants without HF, showed that higher omega-3 levels were linked to a 21% lower risk of developing HF over nearly 14 years.

For those already diagnosed with HF, higher omega-3 levels significantly reduced the risk of all-cause and cardiovascular mortality by around 50%. These findings suggest that boosting omega-3 intake could be beneficial for heart health.

7.5

Improved heart health

Most Useful Review

3816 people found this helpful

Quality product! This fish oil is excellent for health conscious individuals. It provides a good dose of fatty acids and comes from a reputable manufacturer. At 32, I take these capsules for my hair and skin. After various diets, fish oil has been a saviour: my skin is supple, and my hair is less damaged. My parents ordered it for heart disease; my mother, 55, noticed improvement in energy and skin condition. I recommend this product, taking 2 capsules 1-3 times daily with meals. The large capsules are easy to swallow.

Polycystic Ovary Syndrome details

Effective PCOS remedy

Ok Inositol from NOW brand is effective for female hormone balance. It serves as a safe remedy for Polycystic ovary syndrome (PCOS), helps with metabolism, supports weight loss, lowers cholesterol levels, and increases the likelihood of pregnancy.

Rheumatoid Arthritis details

Wang W, Xu Y, Zhou J, Zang Y. Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. Clin Rheumatol. 2024;43:2479. doi:10.1007/s10067-024-07040-0

Based on 16 Researches

Omega-3 shows potential benefits

We examined the effects of omega-3 supplementation on rheumatoid arthritis through a meta-analysis of 18 randomized controlled trials involving over 1,000 patients.

Our findings showed that omega-3 increased beneficial fatty acids and decreased triglyceride levels and tender joint counts.

However, while there were some reductions in inflammation markers, these changes weren't statistically significant, suggesting that omega-3 might not drastically alter disease activity overall.

Supports cardiovascular health

Most Useful Review

14 people found this helpful

Omega-3 is vital for preventing conditions like atherosclerosis and regulating cholesterol levels. Recommended doses vary, but significantly higher amounts are suggested for serious health issues, including rheumatoid arthritis. It’s essential to read labels for the EPA and DHA content to ensure you're getting a quality product. This supplement’s properties extend to numerous health benefits and should be taken seriously.

Swollen Lymph Nodes details

Cancer prevention noted

32 people found this helpful

Omega-3 is essential for cardiovascular health, reducing cholesterol and aiding in cancer prevention. It alleviates skin issues and aids in healing wounds, demonstrating positive results in treating gastric ulcers. Its anti-inflammatory properties enhance mobility and reduce pain in arthritis. This supplement supports brain function, providing energy and improving memory. Recommended intake is three capsules daily during meals.

Arthritis details

Omega-3 benefits joint health in RA

Based on 37 Researches

We analyzed various trials to see how omega-3 fish oil affects rheumatoid arthritis (RA). Our research included 18 randomized controlled studies with 1,018 RA patients. The results showed omega-3 supplementation significantly increased beneficial omega-3 fatty acids, like EPA and DHA, and reduced triglycerides and tender joint count.

However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.

Improves arthritis mobility

Most Useful Review

1 people found this helpful

Excellent for arthritis! I have advanced post-traumatic arthritis in my ankle, and Now Foods Omega-3 has helped eliminate pain and improve mobility. Highly recommended!

Chronic Cough details

My mother struggled with chronic inflammation for a while, with concerns it could be arthritis. However, after several months of taking this product, she feels considerably better and has stopped using medication. The capsules are small, tasteless, and of excellent quality, making them a great addition to her health routine.

Gout details

Stamp LK, Grainger R, Frampton C, Drake J, Hill CL. Effect of omega-three supplementation on serum urate and gout flares in people with gout; a pilot randomized trial. BMC Rheumatol. 2022;6:31. doi:10.1186/s41927-022-00263-1

Based on 6 Researches

Fish oil's limited effect on gout

We conducted a pilot study to examine how omega-3 supplementation from fish oil affects gout in individuals with elevated serum urate levels. Our research involved 40 participants who were split into two groups: one group received 6.2 grams of omega-3 fish oil daily, while the other group did not receive any fish oil for a period of 24 weeks.

Throughout the study, we measured serum urate concentrations, weight, and body mass index (BMI) monthly. Unfortunately, we found that there was no significant difference in serum urate levels or body weight changes between those who took fish oil and those who didn’t.

Interestingly, we discovered a notable correlation between higher omega-3 levels in the blood and a reduction in gout flare-ups among participants in the fish oil group. However, despite this link, the primary measures regarding serum urate and weight did not show meaningful improvement. Some participants reported mild gastrointestinal issues related to the omega-3 supplements, but overall, these supplements were well-tolerated.

This study shows that while omega-3 fish oil does not significantly affect serum urate levels or BMI, there may be potential benefits in reducing the frequency of gout flares. Based on these findings, further large-scale trials are encouraged to explore the role of fish oil as a preventive treatment for gout.

7.5

Health improvement

Most Useful Review

1 people found this helpful

My husband previously suffered from gout, but his recent health check scores are nearly excellent. Drinking this has contributed, though it’s not a sole solution.

High Cholesterol details

Omega-3 EPA+DHA improves cholesterol

Zhou Q, Zhang Z, Wang P, Zhang B, Chen C, et al. EPA+DHA, but not ALA, Improved Lipids and Inflammation Status in Hypercholesterolemic Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Mol Nutr Food Res. 2019;63:e1801157. doi:10.1002/mnfr.201801157

We conducted a comprehensive trial to understand how different types of omega-3 fatty acids affect cholesterol levels and inflammation in adults struggling with high cholesterol.

Over 12 weeks, participants took various doses of omega-3s, including EPA and DHA, revealing notable benefits. Those receiving higher doses of EPA and DHA saw their triglycerides drop significantly—by up to 15.78%—compared to controls.

Interestingly, ALA supplementation did not lead to improvements in cholesterol or inflammation status, highlighting the superior role of EPA and DHA in managing these health issues.

Immune system boost

Most Useful Review

253 people found this helpful

We consistently order these Omega-3 capsules. They have significantly strengthened our immune systems and normalised my mother's high cholesterol levels. They have no aftertaste and are easy to swallow, even for children. Their cost is very competitive, making them an excellent choice.

Irritable Bowel Syndrome details

Linsalata M, Ignazzi A, D'Attoma B, Riezzo G, Mallardi D, et al. Relationship between Markers of Gut Barrier Function and Erythrocyte Membrane PUFAs in Diarrhea-Predominant IBS Patients Undergoing a Low-FODMAP Diet. Nutrients. 2024;16. doi:10.3390/nu16162706

Based on 2 Researches

Omega-3 benefits IBS-D gut health

We examined how omega-3 fish oil relates to gut health in patients with diarrhea-predominant irritable bowel syndrome (IBS-D). This involved studying 38 individuals who started a low-FODMAP diet for 12 weeks.

Initially, those with a compromised gut barrier displayed lower omega-3 levels. Post-diet, improvements were noted, with higher omega-3 levels and better gut function. This suggests that omega-3 fatty acids play a crucial role in enhancing gut integrity and may aid in managing IBS-D symptoms.

Better bowel function

Most Useful Review

4 people found this helpful

Unlike other companies' Omega-3 supplements, these do not have a fishy smell and are easy to swallow. I’ve noticed lesser skin issues before my period and improved bowel movements. This is my second purchase, and I will repurchase once I finish.

Cancer details

Omega-3 diet slows cancer progression

Aronson WJ, Grogan T, Liang P, Jardack P, Liddell AR, et al. High Omega-3, Low Omega-6 Diet With Fish Oil for Men With Prostate Cancer on Active Surveillance: The CAPFISH-3 Randomized Clinical Trial. J Clin Oncol. 2025;43:800. doi:10.1200/JCO.24.00608

We explored the impact of a high omega-3, low omega-6 diet with fish oil on men with prostate cancer under active surveillance. In a year-long study involving 100 participants, those following the omega-rich regimen showed a notable 15% decrease in the Ki-67 index, a key marker for cancer progression.

In contrast, the control group experienced an increase in this index. While the diet showed promise in slowing down potential cancer growth, no significant differences were noted in other cancer-related measurements. Our findings encourage further research on dietary strategies in prostate cancer management.

7.5

Antioxidant properties

Most Useful Review

122 people found this helpful

Omega-3 has been beneficial for various systems in the body, improving memory, and normalising metabolism. A shortage can lead to atherosclerosis and other health issues. These fatty acids also have antioxidant properties that may help prevent cancer. I find Omega-3 purifies blood vessels and improves conditions such as allergies, skin diseases, and diabetes. Overall, it's vital for maintaining good health.

Cardiovascular Disease details

Omega-3 levels reduce heart failure

Based on 33 Researches

We investigated the link between plasma omega-3 levels and the risk of heart failure (HF) in a large UK cohort study. Our analysis revealed that higher omega-3 levels were associated with a 21% lower chance of developing HF over nearly 14 years.

For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.

7.5

Supports cardiovascular health

Most Useful Review

491 people found this helpful

Strengthening the cardiovascular system, Omegas from this company have been incredibly effective for me! Each product has its merits, and this one stands out for support in the cardiovascular system due to its high EPA content. For brain activity enhancement, opt for Omega with higher DHA, although this also has a substantial DHA level. Please like if you found my review helpful!

Celiac details

Trustworthy supplement

NOW Foods Omega-3 is an effective supplement for my health. The high potency ensures I’m getting adequate omega-3, especially since I don’t consume much fatty fish. The softgel format is convenient, easy to swallow, and free from common allergens like gluten, which is essential for me. This supplement has become a reliable part of my health regimen.

Constipation details

Aids constipation relief

This helps with constipation after use.

Diabetes details

Sugasini D, Yalagala PCR, Park JC, Ma G, Farooq Z, et al. Retinal Docosahexaenoic Acid Is Significantly Reduced in Diabetic Humans and Mice: Possible Relationship to Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2024;65:39. doi:10.1167/iovs.65.14.39

Based on 16 Researches

Reduced retina DHA in diabetes

We investigated the impact of diabetes on the levels of docosahexaenoic acid (DHA), an essential omega 3 fatty acid, in the retina of humans and mice. Our findings revealed that diabetic individuals had significantly lower DHA levels—40% less in peripheral regions and 25% less in the macula—compared to those without diabetes.

Additionally, we observed a reduction of retinal thickness and function in diabetic mice. Although there’s potential for dietary DHA to help with diabetic retinopathy, the current study suggests that diabetes is linked to reduced DHA and related retinal defects.

7.5

Positive mood enhancement

Most Useful Review

17 people found this helpful

Excellent value for Omega-3! I take it for diabetes and find it boosts my mood. It's crucial for our bodies since we can't produce it ourselves. Omega-3 has numerous benefits, including reducing harmful fats in blood, aiding mental health, and supporting heart function. I recommend this supplement for anyone, especially for sports and overall well-being.

Frozen Shoulder details

2 people found this helpful

I straightened my hair eight years ago, which ruined it, causing brittle strands and significant hair fall. After using Omega-3 and Gold C for two months, my hair loss has decreased remarkably, returning to a normal level, although I also deal with frozen shoulder.

Indigestion details

No indigestion observed

2 people found this helpful

Since we don’t eat fatty sea fish twice a week, I consider omega a necessity for a complete diet, beneficial for hair, nails, and skin. The capsules are large but easy to swallow without any fishy odour, belching, or indigestion, which often occurs with pharmaceutical fish oil.

Food Poisoning details

Liao J, Bi S, Fang Z, Deng Q, Chen Y, et al. Docosahexaenoic Acid Promotes Cd Excretion by Restoring the Abundance of in Cd-Exposed Mice. Molecules. 2023;28. doi:10.3390/molecules28104217

Likely Very Effective

DHA promotes cadmium excretion

We explored the effects of docosahexaenoic acid (DHA) on cadmium (Cd) exposure, a common pollutant that risks human health through the food chain. Our investigation focused on how DHA might help mitigate the harmful effects of Cd, particularly by looking at changes in gut microbiota.

The study involved examining mice that had been exposed to cadmium. We observed that DHA significantly boosted the amount of cadmium expelled in feces while reducing the levels of cadmium accumulated in various organs. Our findings highlighted a particularly encouraging increase in Parabacteroides, a beneficial bacteria in the gut that appeared to play a crucial role in this process.

We noted that the representative strain of Parabacteroides not only demonstrated the ability to reduce Cd toxicity but also helped repair gut damage inflicted by cadmium exposure. Furthermore, DHA effectively reduced cadmium levels in organs such as the liver, spleen, and kidneys, leading to a noticeable increase in cadmium excretion.

Overall, our results suggest that DHA may have significant potential in promoting the excretion of cadmium in instances of exposure. This insight offers a fascinating avenue for considering DHA as a supportive treatment option for handling heavy metal toxicity.

Improved cholesterol levels

Most Useful Review

26 people found this helpful

30% useful Omega-3 acids PUFA in one capsule has been taken by my family as our diet could be more varied. We trialled this but found that Now Foods' other products offer better alternatives. We carefully examine the composition when selecting omega-3s, focusing on EPA and DHA. The combined content totals 1000 mg, meaning I need to take three capsules, which isn’t very cost-effective, and there's excessive saturated fat. While many dislike the ethyl esters form, we prefer triglycerides. Thanks to Omega-3, my husband’s health metrics improved, his cholesterol rose, and his atherogenic coefficient normalised. Omega-3 works, and we’ll opt for Oslomega next time due to its superior composition.

Depression details

Wu SK, Yang KJ, Liu WC, Malau IA, Zailani H, et al. The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Nutrients. 2024;16. doi:10.3390/nu16213688

Based on 30 Researches

Omega-3 fatty acids show promise

We conducted a study to see if omega-3 fatty acids could help people with major depressive disorder as a standalone treatment. Over 12 weeks, 60 participants took either omega-3 supplements or a placebo.

Results showed that those taking omega-3 had lower depression scores at various points throughout the study. While there were hints of improved outcomes in terms of remission and response rates, these weren't statistically significant.

Overall, omega-3 fatty acids could be a promising alternative, but further research is necessary to confirm their effectiveness.

Improved skin condition

Most Useful Review

7 people found this helpful

Omega-3 fatty acids are essential and must be obtained from food or supplements, as the body cannot produce them. They help manage depression and improve skin health. Many individuals with conditions like eczema find their skin improves with Omega-3 intake. I noticed better sleep and increased energy levels after taking Omega from NOW FOODS. It offers a great price-to-quality ratio with 200 capsules lasting for three months.

Ulcer details

Eicosapentaenoic acid aids ulcer healing

Moderately Effective

Based on 26 Researches

El Mahdy RN, Nader MA, Helal MG, Abu-Risha SE, Abdelmageed ME. Eicosapentaenoic acid mitigates ulcerative colitis-induced by acetic acid through modulation of NF-κB and TGF-β/ EGFR signaling pathways. Life Sci. 2023;327:121820. doi:10.1016/j.lfs.2023.121820

We examined how Eicosapentaenoic acid (EPA) could protect against ulcerative colitis (UC), a chronic condition that inflames the large intestine. In our research, we used acetic acid to induce UC in rats, administering oral EPA for 28 days in doses of 300 and 1000 mg/kg before the acetic acid treatment.

Our findings were quite promising. EPA appeared to significantly alleviate UC symptoms, as seen in the improved colonic health of the rats. We noted that EPA treatment not only reduced inflammation but also helped restore the balance between oxidants and antioxidants in the body. This balance is crucial for maintaining a healthy gut environment and reducing tissue damage.

Moreover, EPA led to the enhancement of protective proteins in the colon, while it suppressed markers associated with inflammation. This included reductions in substances that typically signal more inflammation, which suggests that EPA has a dual role—enhancing protective factors while diminishing harmful responses. We believe these insights highlight the potential of EPA as a therapeutic agent for managing UC more effectively.

7.5

Ulcer pain relief

Most Useful Review

After two years of taking these vitamins, I can confidently say they support my health. I’ve noticed skin and mood improvements and a reduction in joint inflammation. They work effectively for treating ulcers, as I experienced less discomfort when following the daily dosage. However, I need to be cautious about certain conditions and interactions.

Bloating details

Omega-3s help reduce PMS bloating

Sohrabi N, Kashanian M, Ghafoori SS, Malakouti SK. Evaluation of the effect of omega-3 fatty acids in the treatment of premenstrual syndrome: "a pilot trial". Complement Ther Med. 2013;21:141. doi:10.1016/j.ctim.2012.12.008

We observed the effectiveness of omega-3 fatty acids in treating symptoms of premenstrual syndrome (PMS) in a well-structured study with 184 women. Participants were divided into two groups, receiving either omega-3 supplements or a placebo over three months.

Encouragingly, we found that those taking omega-3 reported reduced bloating along with other symptoms like anxiety and headaches. Furthermore, these benefits increased with longer treatment durations. Overall, omega-3 fatty acids show promise for alleviating bloating in women suffering from PMS.

Bloating relief

Most Useful Review

Super Omega! The quality is good for the price. The jar contains a substantial 200 capsules. While they are large, I have no issues swallowing them. My husband and I took 2 capsules twice daily for a month, and I've noticed an improvement in my overall well-being and reduction in bloating. I feel less stressed at work, and I'm placing another order for regular use.

Hypertension details

Eicosapentaenoic acid benefits hypertension

Asulin M, Gorodetzer N, Fridman R, Shelly Ben-Shushan R, Cohen Z, et al. 5,6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP signaling pathway. Biochem Biophys Res Commun. 2024;700:149585. doi:10.1016/j.bbrc.2024.149585

We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.

Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.

Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.

Pressure increased

Most Useful Review

3 people found this helpful

I have hypertension and have been taking Omega-3 capsules for a month alongside coenzyme Q10. They are large but easy to swallow, and I haven't experienced any side effects. Since starting, my palpitations have ceased, and my blood pressure has decreased. I'll continue taking them.

Kidney Stones details

Eicosapentaenoic acid reduces stone risk

Moderately Effective

Based on 7 Researches

Siener R, Jansen B, Watzer B, Hesse A. Effect of n-3 fatty acid supplementation on urinary risk factors for calcium oxalate stone formation. J Urol. 2011;185:719. doi:10.1016/j.juro.2010.09.074

We explored the effects of eicosapentaenoic acid, an omega-3 fatty acid, on urinary factors linked to the formation of calcium oxalate kidney stones. In our study, we had 15 healthy participants follow a standardized diet over several phases to assess how daily supplementation with eicosapentaenoic acid and docosahexaenoic acid influenced their urinary excretion of calcium and oxalate.

Initially, during a 5-day control phase, we collected daily urine samples and observed no changes in the urinary parameters. However, after 30 days of supplementation, we noted a significant decrease—23%—in the relative supersaturation of calcium oxalate, primarily due to reduced oxalate excretion. This suggests that the supplementation may lower the risk of stone formation by affecting how the body manages oxalate.

Our findings propose that long-term use of eicosapentaenoic acid could be beneficial for those prone to calcium oxalate stones. The beneficial effect appears to arise from changes at the cellular level, altering how oxalate is exchanged. In summary, eicosapentaenoic acid supplementation holds promise as a preventive measure against kidney stones for certain individuals.

7.5

Improved health

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4 people found this helpful

I started using Now supplements to enhance my overall health, and I have noticed significant improvement. I have Chronic Kidney Disease (CKD) and must be cautious about the supplements I take. These have notably helped me with the anaemia related to CKD. The pills are easy to swallow, offer great value, and I barely notice any taste when I take them.

Leg Cramps details

As a new iHerb customer, I’m thrilled! I ordered Now Foods omega-3 and noticed remarkable benefits after taking it with vitamin D3. My legs no longer hurt, and I feel much more energetic. I sceptically recommend it for those hesitant about supplements.

Rash details

Rhodes LE, White SI. Dietary fish oil as a photoprotective agent in hydroa vacciniforme. Br J Dermatol. 1998;138:173.

Based on 3 Researches

Promising results for fish oil

We investigated the impact of dietary fish oil, rich in omega-3 fatty acids, on hydroa vacciniforme, a challenging photosensitivity disorder. Three boys with the condition took five capsules of MaxEPA daily for three months. During follow-up tests, we observed that all boys had lower sensitivity to UVA light, indicating a positive response to the treatment.

While one child demonstrated a significant improvement, another showed mild progress, and the third did not improve but later responded well to another medication. Overall, fish oil may reduce UV sensitivity and improve rash outcomes for some patients.

7.5

Improved skin appearance

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39 people found this helpful

After taking a course of this omega-3, I feel well; the appearance of my skin on the face and body has greatly improved and various rashes have disappeared.

Athlete’s Foot details

Foot numbness has disappeared. My blood circulation is improved, and I really like this product. I used to experience cramping in my foot constantly, but after taking Omega for some time, those issues have resolved.

Autoimmune Disorder details

Resolvin D1 impacts lupus progression

Huang L, Wu J, Cao J, Sheng X, Wang M, et al. Resolvin D1 inhibits T follicular helper cell expansion in systemic lupus erythematosus. Scand J Rheumatol. 2024;53:276. doi:10.1080/03009742.2024.2344906

We focused on how Resolvin D1 (RvD1), a pro-resolving lipid, impacts systemic lupus erythematosus (SLE). Our study measured RvD1 levels and T follicular helper (Tfh) cell counts in SLE patients versus healthy individuals.

We found that higher RvD1 levels correlated with lower disease activity and fewer Tfh cells. RvD1 was effective in reducing Tfh cell activity in a mouse model and inhibited Tfh differentiation in lab tests.

Overall, RvD1 appears to play a significant role in managing SLE by suppressing Tfh cells and influencing immune responses.

Stable blood pressure

Most Useful Review

55 people found this helpful

I ordered an antihypertensive kit for my mother and found it recommended fish oil, taurine, and magnesium. After six months of use, her blood pressure has stabilised with rare spikes. She has significantly reduced her main medications, and I'm pleased with the price and quality of this product.

Pancreatitis details

Eicosapentaenoic acid aids pancreatic health

Based on 7 Researches

Zou HY, Zhang HJ, Zhao YC, Li XY, Wang YM, et al. N-3 PUFA Deficiency Aggravates Streptozotocin-Induced Pancreatic Injury in Mice but Dietary Supplementation with DHA/EPA Protects the Pancreas via Suppressing Inflammation, Oxidative Stress and Apoptosis. Mar Drugs. 2023;21. doi:10.3390/md21010039

We investigated the effects of eicosapentaenoic acid (EPA) on pancreatic injury, particularly in the context of conditions that mimic pancreatitis. Our study began by creating a mouse model with a deficiency in n-3 polyunsaturated fatty acids (PUFAs) to evaluate how this lack impacts pancreatic function and injury.

The findings were quite striking. In the absence of n-3 PUFAs, the mice experienced significant pancreatic impairment, including reduced insulin levels and decreased health of pancreatic islets. However, when we introduced dietary EPA and DHA—both forms of n-3 PUFAs—prior to inflicting pancreatic damage, we observed remarkable protective effects. Specifically, the treatment with EPA led to notable increases in insulin production and improved overall islet function.

Additionally, our research highlighted that these protective effects of EPA may stem from its ability to modulate inflammation, oxidative stress, and apoptosis in pancreatic tissues. This suggests that dietary adjustments, especially increasing n-3 PUFAs like EPA, could be a beneficial strategy to support pancreatic health and combat injuries associated with conditions like pancreatitis.

No exacerbations

Most Useful Review

Good omega, but should be taken with caution in pancreatitis. I took 1 capsule after meals and had no issues or exacerbations.

Acne details

Guertler A, Neu K, Lill D, Clanner-Engelshofen B, French LE, et al. Exploring the potential of omega-3 fatty acids in acne patients: A prospective intervention study. J Cosmet Dermatol. 2024;23:3295. doi:10.1111/jocd.16434

Based on 11 Researches

Omega-3 improves acne severity

We observed that omega-3 fatty acids, particularly EPA and DHA, could be beneficial for patients struggling with acne. Over 16 weeks, 60 participants followed a Mediterranean diet and received algae-derived omega-3 supplements.

We found that most patients initially had low omega-3 levels, but these rose significantly during the study. Acne severity showed notable improvement, especially in those achieving optimal omega-3 levels. Though four patients reported worsened appearance, overall quality of life improved for the majority.

7.5

Reduced acne

Most Useful Review

150 people found this helpful

Omega 3 is brilliant, with a convenient dosage. Although the capsule is somewhat large, it is easy to swallow and is absorbed well, leaving no fishy aftertaste. The results are evident; my acne has decreased significantly, and the overall quality of my skin has improved.

Diarrhea details

Takenouchi S, Imai D, Nakamura T, Murata T. Efficient Attenuation of Dextran Sulfate Sodium-Induced Colitis by Oral Administration of 5,6-Dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic Acid in Mice. Int J Mol Sci. 2021;22. doi:10.3390/ijms22179295

Based on 8 Researches

5,6-DiHETE alleviates diarrhea

We examined how eicosapentaenoic acid, specifically a compound called 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid (5,6-DiHETE), affects diarrhea caused by inflammation in mice. In our study, the mice were given a substance that induces colitis, known as dextran sulfate sodium (DSS), and then treated with different doses of 5,6-DiHETE orally.

What we found was promising: the administration of both 150 and 600 micrograms of 5,6-DiHETE daily helped to speed up the recovery from diarrhea. After just a few days of treatment, we observed significant improvements in the mice’s condition. The daily doses led to less inflammation in the colon and a notable reduction in the symptoms of diarrhea associated with DSS-induced colitis.

We also measured how much of this compound remained in the mice's blood after taking it, finding that it peaked within half an hour of administration. This suggests that 5,6-DiHETE works relatively quickly to start affecting the inflammation. Overall, our research indicates that eicosapentaenoic acid holds potential as a beneficial treatment for inflammatory bowel diseases that cause diarrhea.

No diarrhoea

Most Useful Review

I was concerned that the iHerb brand of Omega-3 would upset my stomach and cause diarrhoea like others have, but I am pleased to say it didn't affect me negatively at all. I took it without experiencing any digestive issues.

Cholecystitis details

Improved vessel health

Excellent Omega! I've regularly taken this for over a year, just one capsule each morning with breakfast. My vessels improved, and my gallbladder function is better. I recommend it for both men and women. Stay healthy!

Chest Pain details

Mizia-Stec K, Mizia M, Haberka M, Lasota B, Gieszczyk-Strózik K, et al. N-3 polyunsaturated fatty acids do not influence the efficacy of dual antiplatelet therapy in stable angina pectoris patients after percutaneous coronary intervention. Cardiol J. 2013;20:478. doi:10.5603/CJ.2013.0132

Based on 17 Researches

Omega-3 fish oil ineffective

We examined whether taking omega-3 fatty acids could enhance the effects of dual antiplatelet therapy for patients dealing with stable angina after heart procedures. Our study involved 40 patients who were split into two groups: one received omega-3 alongside standard medication, while the other did not.

After testing platelet activity over time, we found no significant differences between the two groups. This suggests that omega-3 fish oil does not provide additional benefits for managing chest pain in these patients.

Not effective for chest pain

Most Useful Review

6 people found this helpful

Omega-3s are crucial for health, known since the 1930s. However, I didn’t find any specific effect on my chest pain from this product. I experienced fishy burps, and while studies show benefits, my personal experience wasn’t satisfactory.

Insomnia details

Eicosapentaenoic acid shows limited benefits

Based on 2 Researches

Watanabe N, Matsuoka Y, Kumachi M, Hamazaki K, Horikoshi M, et al. Omega-3 fatty acids for a better mental state in working populations - Happy Nurse Project: A 52-week randomized controlled trial. J Psychiatr Res. 2018;102:72. doi:10.1016/j.jpsychires.2018.03.015

We explored the effectiveness of eicosapentaenoic acid, a type of omega-3 fatty acid, on insomnia among junior hospital nurses in a well-structured trial. In this study, 80 nurses were randomly assigned to receive either 1200 mg of eicosapentaenoic acid along with 600 mg of docosahexaenoic acid daily or a placebo for 13 weeks.

Our main focus was to see how these supplements influenced insomnia and overall mental health. While we noted some improvements in various measures, including insomnia severity at the 13-week mark, the results didn't demonstrate a significant advantage when compared to the placebo group.

After analyzing data at multiple checkpoints—13, 26, and 52 weeks—we found that the effects of eicosapentaenoic acid on insomnia were not strong enough to conclude it as a beneficial treatment. Overall, while there were some positive indicators at certain times, the overall impact on insomnia was not substantial, leaving us to conclude that more research is needed to confirm any real benefits from omega-3 fatty acids for sleep disturbances.

Effective for insomnia

Most Useful Review

I have bought this product three times and find it very beneficial for my chronic insomnia.

Blood Clot details

Fish oil reduces catheter-related clots

Based on 29 Researches

Jami MM, Bhardwaj V, Merritt RJ. Intravenous Fish Oil Lipid Emulsion Prevents Catheter-Related Thromboses in Pediatric Patients with Intestinal Failure. J Pediatr. 2018;198:301. doi:10.1016/j.jpeds.2018.03.029

We analyzed the effects of fish oil lipid emulsion on the prevention of deep vein thrombosis in children with intestinal failure.

In this study, we compared 35 pediatric patients receiving a soy oil lipid emulsion with 35 who received fish oil.

Remarkably, none of the children in the fish oil group experienced blood clots, whereas the soy oil group had ten cases. This suggests that fish oil lipid emulsion may significantly reduce the risk of clots associated with central venous catheters.

Cholesterol reduction

Most Useful Review

210 people found this helpful

My husband, who enjoys food a bit too much, found himself with a high level of 'bad' cholesterol at 8.6. After following a doctor’s advice, including omega-3 supplements, and modifying his diet, his cholesterol dropped to 5.6 after 2.5 months! This product truly works in treating blood clots. I highly recommend it.

Gastritis details

Correia M, Michel V, Osório H, El Ghachi M, Bonis M, et al. Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid. PLoS One. 2013;8:e60657. doi:10.1371/journal.pone.0060657

Based on 3 Researches

DHA reduces H. pylori effects

We aimed to understand how docosahexaenoic acid (DHA) impacts the growth of Helicobacter pylori, a common bacteria linked to gastritis and other stomach disorders. Our research focused on how DHA influences bacterial adhesion to stomach cells and reduces inflammation associated with infection.

At concentrations of 100 µM, DHA effectively reduced H. pylori growth, while higher amounts of 250 µM or more led to irreversible effects on bacterial survival. We noted that DHA not only hindered bacterial growth but also decreased the bacteria's ability to attach to gastric epithelial cells. Moreover, we found that cells infected with DHA-treated H. pylori showed significantly lower levels of Interleukin-8 (IL-8), an inflammatory marker, alongside reductions in other inflammatory proteins.

Through our analysis, we discovered that DHA alters the outer membrane proteins of H. pylori, which are involved in its stress response and metabolism. These changes seem to contribute to lesser adhesion to stomach cells and a reduced inflammatory response. These findings suggest that DHA could be a beneficial alternative in managing H. pylori-related gastritis by targeting the bacteria and its effects on the stomach.

Healed gastritis

Most Useful Review

Not bad, and the capsules aren’t overly large. This form seems to help address my gastritis effectively.

Reflux details

Resolvin D1's role in GERD treatment

Zhao Y, Ma T, Zhang Z, Chen X, Zhou C, et al. Resolvin D1 attenuates acid-induced DNA damage in esophageal epithelial cells and rat models of acid reflux. Eur J Pharmacol. 2021;912:174571. doi:10.1016/j.ejphar.2021.174571

We investigated the role of resolvin D1 (RvD1) in protecting esophageal epithelial cells from damage caused by acid reflux. Through exposure tests, we found that RvD1 could effectively block oxidative stress and DNA damage linked to acid exposure.

Notably, RvD1 not only reduced harmful reactive oxygen species but also enhanced the cell's ability to repair DNA damage, signaling a promising potential for treatment in patients with gastroesophageal reflux disease. However, we need more studies to confirm its benefits in clinical settings.

No reflux noted

Most Useful Review

5 people found this helpful

I am very impressed with the quality of these omega-3 soft capsules. Despite their size, they're easy to swallow, with no reflux, taste, or smell. I've experienced improved mental clarity, a significant reduction in my LDL (bad cholesterol), and my memory has greatly improved. I am extremely satisfied! Thank you, IHERB.

Nausea details