NOW Supplements Turmeric Curcumin

Curcumin improves rheumatoid arthritis symptoms

The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial.

Most Relevant Research

We conducted a clinical trial to explore how curcumin, a compound found in turmeric, affects women with rheumatoid arthritis (RA). Over the course of eight weeks, 48 participants took either a daily curcumin capsule or a placebo. This double-blind, placebo-controlled design ensured that neither the participants nor the researchers knew who was receiving the actual treatment, which adds credibility to our findings.

At the end of the study, we observed some encouraging results. Women who took curcumin showed a significant increase in their serum total antioxidant capacity (TAC), indicating improved antioxidant levels in their bodies. Additionally, these participants experienced a notable decrease in symptoms like tender and swollen joints, pain intensity, and overall disease activity, as measured by the Disease Activity Score in 28 joints (DAS-28).

While levels of malondialdehyde (MDA)—a marker of oxidative stress—decreased in the curcumin group, the change wasn't significantly different when compared to the placebo group. Overall, our findings support the idea that curcumin can be beneficial for women with RA, particularly in reducing disease activity and enhancing antioxidant levels.

9.5

Miraculous joint relief

Most Useful Review

A tool that truly works! I ordered this product to maintain joint health, and I was pleased to feel its effects surprisingly quickly. Joint pain decreased, and I noticed an unexpected boost in my energy and mood. This remedy has become essential for me, as I now feel revitalised and energetic.

Back Pain

Turmeric-Boswellia improves back pain

Based on 3 Researches

The effect of turmeric-Boswellia formulation (Rhuleave-K) in posture-related low back soreness and discomfort: A randomized double blinded placebo controlled trial.

Most Relevant Research

We investigated how a turmeric and Boswellia formulation, known as Rhuleave-K, helps manage low back pain related to poor posture. This study involved 52 participants, equally divided by gender, who had been experiencing discomfort for at least two to three weeks.

Using a randomized, placebo-controlled, and double-blinded approach, we carefully measured the pain intensity at the beginning and again at the end of the 15-day trial. The findings were promising; those taking Rhuleave-K experienced a dramatic reduction in pain—showing a reduction of up to 98.5% by the end of the trial. In comparison, the placebo group reported minimal improvement.

We also noted significant decreases in the Oswestry disability index, indicating that participants not only had less pain but also felt increasingly able to carry out daily activities. Overall, this study supports the idea that Rhuleave-K can be a safe and effective option for those looking to alleviate low back discomfort, specifically due to poor posture.

8.8

Improved family health

Most Useful Review

Although I didn't notice a significant personal benefit from this product, it's made a stark difference for my family. My dad has been able to play squash regularly without pain, and I continue to order it for my parents because of the benefits they've experienced.

Blood Clot

Curcumin inhibits platelet activation

Based on 7 Researches

Curcumin Modulates Platelet Activation and ROS Production Induced by Amyloid Peptides: New Perspectives in Attenuating Prothrombotic Risk in Alzheimer's Disease Patients.

Most Relevant Research

We explored how curcumin, a natural compound found in turmeric, affects platelet activation specifically when stimulated by amyloid peptides associated with Alzheimer’s disease. The research aimed to determine if curcumin could help modulate these potentially harmful blood clotting responses.

Using isolated human platelets, we assessed how curcumin influences platelet aggregation and the production of reactive oxygen species. Our findings revealed that curcumin successfully suppressed platelet aggregation triggered by amyloid peptides. This suppression was linked to a decrease in critical signaling pathways involved in platelet activation.

Interestingly, while curcumin significantly inhibited responses to amyloid peptides, its effects on platelet activation induced by standard physiological triggers like thrombin and convulxin were less pronounced. Granule secretion, another aspect of platelet activation, was completely suppressed by curcumin only in response to the hemostatic stimuli, not in the presence of amyloid peptides.

Overall, it seems that curcumin may offer a targeted approach to mitigate the risk of blood clot formation in individuals suffering from Alzheimer’s disease, particularly concerning the pathological roles of amyloid peptides.

8.8

Liver benefits

Most Useful Review

"The PC has shown benefits for the liver, intestines, and lungs. Curcumin Phytosome, which is a curcumin molecule attached to PC (PhosphatidylCholine), is excellently absorbed. It transports curcumin effectively across the intestinal lining into the blood, making it over 29 times better absorbed than curcumin alone."

Bone Pain

Fantastic supplement for arthritis sufferers! I suffer from Rheumatoid arthritis in my wrists, knees, and back. After taking Curcumin, my life has become much more manageable with significantly less bone pain. I now feel nearly pain-free. This supplement energises me and motivates me to exercise, but caution is needed – too much activity can lead to acute pain. Thanks to iHerb for great prices and fresh supplements.

Knee Pain

Curcumin alleviates knee osteoarthritis pain

An Investigation into the Effects of a Curcumin Extract (Curcugen) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study.

Most Relevant Research

In a well-structured study involving 101 adults suffering from knee osteoarthritis, we explored the effects of curcumin, a compound derived from turmeric, on knee pain. Participants were randomly assigned to receive either 500 mg of a standardized curcumin extract, Curcugen, twice daily, or a placebo for eight weeks, allowing for a clear comparison of its effectiveness.

Our findings revealed promising results. Curcumin significantly reduced knee pain scores and overall pain ratings compared to the placebo. We also noticed that participants taking curcumin showed greater improvements in various physical tests, like the timed up-and-go and six-minute walk tests, indicating enhanced mobility.

Interestingly, 37% of those on curcumin reduced their pain medications, which highlights the potential for curcumin to provide relief and improve quality of life for those with this condition. While the study didn’t explore longer treatment durations or different dosages, these initial results support curcumin's role as a feasible option for managing osteoarthritis pain in the knee.

9.5

Significant pain relief

Most Useful Review

Curcumin has greatly improved my rheumatoid arthritis symptoms in my wrists, knees, and back. I no longer rely on painkillers, and I feel near pain-free. This supplement energises me, but I advise exercising with caution to avoid overdoing it. iHerb offers great prices and fresh products.

Liver Disease

Turmeric shows promise for NAFLD

"Evaluation of Curcuma zedoaria Rosc. in the management of non-alcoholic fatty liver Disease: A Randomized, single blind, controlled trial".

Most Relevant Research

In a recent clinical trial, we explored the effectiveness of Curcuma zedoaria Rosc., commonly known as turmeric, in treating non-alcoholic fatty liver disease (NAFLD). This condition is alarmingly widespread, affecting a significant portion of the global population. Over the course of 60 days, we compared turmeric with vitamin E, a standard treatment, to see which had better results.

Our study involved 68 patients with mild to moderate NAFLD, who were divided into two groups. One group received turmeric in capsule form, while the other took vitamin E. We looked at various outcomes, including improvements in liver function, symptoms like digestive issues and malaise, and ultrasound assessments of liver size.

The findings were compelling. We observed that turmeric outperformed vitamin E in alleviating subjective symptoms, such as discomfort in the upper right abdomen, and issues with appetite and digestion. Notably, there were no significant adverse effects reported with turmeric, making it a promising alternative for managing NAFLD.

Overall, our research highlights turmeric as a viable option for those seeking treatment for liver disease, offering benefits that may surpass those of conventional therapies.

9.5

Effective for liver inflammation

Most Useful Review

I purchased this for my dog, who had liver inflammation. Despite curcumin's low bio-availability in turmeric form, giving him 1 gm/day for ten days lowered his ALT levels significantly. It shows great promise as an anti-inflammatory, and I appreciate the efforts of Indena, the manufacturer.

Allergies

Curcumin shows no allergy test effects

Based on 10 Researches

Curcumin does not significantly affect immediate skin tests.

Most Relevant Research

We focused on how turmeric, specifically curcumin, might influence allergies. Our study involved 34 participants who were allergic to certain antigens. To assess the effect of curcumin, we randomly assigned participants to receive either curcumin or a placebo for one week, all while keeping the study double-blind to eliminate bias.

After this week, we conducted skin-prick tests to measure reactions before and after the treatment. We compared the size of the skin test reactions, or wheals and flares, to see if there were any significant changes.

The results were clear: curcumin did not show a statistically significant impact on the size of these reactions. Although earlier studies suggested that curcumin may help reduce allergic symptoms, our findings indicate that it does not change the immediate response measured through skin tests. Thus, there's no need to stop using curcumin before allergy testing since it doesn't interfere with the results.

9.5

Alleviates joint pain

Most Useful Review

This anti-inflammatory supplement is fantastic! I’m allergic to aspirin and many NSAIDs induce hives. After three weeks, my joint pain has significantly decreased. I’ve had no allergic reactions and my doctor recommends turmeric. It’s been a beneficial addition to my wellness routine.

Cancer

My cat loves this! After being diagnosed with nasal lymphoma, this has helped keep him alive. His symptoms, including sneezing and nasal mucous, have improved significantly. The vet suggested radiation or chemotherapy, but I’ve solely used curcumin for his treatment. Despite previously using another brand, I switched to this one, which is highly rated by ConsumerLab. I mix half a capsule daily with his wet food, and he enjoys it. I am incredibly grateful that this has kept my little friend alive.

Cardiovascular Disease

Curcumin protects heart cells effectively

Based on 8 Researches

Curcumin pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis, autophagy and apoptosis via HES1.

Most Relevant Research

We explored how curcumin, a natural compound found in turmeric, can protect heart cells during events like myocardial ischemia/reperfusion injury (I/RI). This type of injury occurs when blood supply returns to the heart after a period of low oxygen, often leading to additional damage to heart tissue.

Through a series of experiments, we observed that curcumin has significant protective effects on heart cells exposed to anoxic stress. Our findings revealed that curcumin improves cell health by reducing cell death, lowering oxidative stress markers, and increasing the body’s antioxidant defenses. Specifically, we noted an increase in important proteins that help protect heart cells, such as HES1 and glutathione peroxidase 4.

Furthermore, curcumin appears to inhibit processes known to contribute to cell death, such as ferroptosis and excessive autophagy, while also reducing apoptosis, which is a form of programmed cell death. This multifaceted approach showcases curcumin's ability to enhance cell survival and maintain heart function during and after ischemic episodes.

Overall, our study supports the potential of turmeric-derived curcumin as a promising natural treatment for reducing the harmful effects of ischemia/reperfusion injury in cardiovascular disease.

9.5

Strong antioxidant properties

Most Useful Review

I recommend this supplement wholeheartedly, regardless of existing health issues. It is an excellent antioxidant and high-quality product for combating inflammation. The benefits extend to fighting cancer as well. The packaging is commendable; this is suitable for adults of all ages.

Chronic Cough

A fantastic supplement that has proven to be effective for managing chronic cough. It was recommended to us during an episode, and it remarkably stopped my coughing within 15-20 minutes, even faster than my inhaler. I am truly impressed!

Heart Disease

Nano-curcumin improves heart health

Effect of nano-curcumin supplementation on angina status, and traditional and novel cardiovascular risk factors in overweight or obese patients with coronary slow flow phenomenon: a randomized double-blind placebo-controlled clinical trial.

Most Relevant Research

We conducted a double-blind, placebo-controlled trial to see how nano-curcumin, a supplement derived from turmeric, affects heart health in overweight or obese patients with a condition known as coronary slow flow phenomenon (CSFP). Our study involved 42 participants who received either 80 mg of nano-curcumin or a placebo daily for 12 weeks.

To measure how angina—a type of chest pain—improved, we used the Seattle angina questionnaire among other cardiovascular risk factors, including endocan, adropin, homocysteine levels, and various lipid profiles.

At the end of the study, we observed that those taking nano-curcumin reported significant improvements in their angina status and some cardiovascular factors, compared to their baseline measures. While some improvements were also seen in traditional and novel risk factors, more research will be needed to understand these changes in depth and whether they offer any real-world benefits for heart health.

9.5

Improves heart health

Most Useful Review

My natural health physician informs me that turmeric is best known for its powerful anti-inflammatory properties, which are crucial in treating heart disease. Curcumin also helps reduce oxidative stress, linked to many diseases, including heart conditions. I have found that supplementing with NOW's Phytosome with Meriva Curcumin is beneficial for my husband and me, providing an excellent absorption rate. This product is a valuable addition to our daily routine for heart health, making it highly recommended.

Alzheimer

Curcumin derivative shows Alzheimer's promise

Based on 12 Researches

New low-dose curcumin derivative with therapeutic potential in Alzheimer's disease: Results from an in vitro and in vivo study in mice.

Most Relevant Research

We examined the potential of a curcumin derivative, known as Derivative 27, to treat Alzheimer's disease (AD). Curcumin, a compound found in turmeric, has previously been recognized for its ability to interfere with amyloid-β (Aβ) peptide aggregates, a hallmark of AD. The study focused on enhancing curcumin's effectiveness at lower doses, aiming to make treatment more accessible for patients.

Through rigorous testing, both in vitro and in vivo, we evaluated the anti-inflammatory, antioxidant, and anti-amyloidogenic properties of Derivative 27. In laboratory settings, the compound showed impressive results by significantly reducing the production of nitric oxide and various pro-inflammatory proteins. Additionally, it activated a key protective transcription factor known as Nrf2, illustrating its potential to combat neuroinflammation.

In a more practical application, we tested Derivative 27 on one-year-old APP/PS1 mice, a model for Alzheimer's. After administering the treatment daily for 28 days, we observed improvements in the mice's short-term spatial memory. Significant reductions in hippocampal pro-inflammatory markers and Aβ levels were also noted, supporting the idea that this new curcumin derivative could be beneficial in the fight against Alzheimer’s.

Overall, this research opens the door to developing modified curcumin compounds that could lead to effective low-dose treatments for Alzheimer's disease, all while highlighting the therapeutic potential of turmeric derivatives in neurodegenerative conditions.

9.5

Curcumin slows memory loss

Most Useful Review

Not only is this Curcumin highly rated, but my Nurse-Practitioner recommended this brand. It was suggested to help slow my husband's memory loss progress. Curcumin, derived from turmeric in curry powder, is shown to decrease beta-amyloid brain plaques associated with Alzheimer's disease and delay neuronal decline.

Eczema

Herbal remedies show promise for eczema

Formulation and clinical evaluation of topical dosage forms of Indian Penny Wort, walnut and turmeric in eczema.

Most Relevant Research

We conducted a study that explored the effectiveness of topical treatments using herbal ingredients, specifically focusing on Indian pennywort, walnut, and turmeric, for managing eczema. Our research included three different formulations—a micro emulsion, gel, and ointment—derived from these extracts. We treated 360 eczema patients in a controlled clinical trial, comparing the results of our formulations with placebo treatments.

Throughout the study, we observed various clinical signs of eczema, including erythema (redness), oedema (swelling), scaling, itching, and lichenification (thickened skin). Interestingly, while each formulation showed benefits, the micro emulsion was particularly effective in reducing redness and swelling. The gel formulation stood out for relieving itching more effectively, whereas the ointment proved to be the best option for managing scaling and lichenification.

It’s important to note that while turmeric was included in our formulations, we couldn't isolate its specific effect due to its combination with other ingredients. However, the overall results suggest that these herbal treatments could serve as promising alternatives for eczema care.

Eczema on hands cleared

Most Useful Review

This is the BEST supplement! After six weeks of taking it daily, my eczema on my hands has completely cleared up. I also no longer get itchy spots on my scalp. I highly recommend this product!

Reflux

Curcuma extract improves reflux symptoms

Based on 5 Researches

Protective Effects of Inflammation of Curcumae Longae Rhizoma 30% EtOH Extract on Acute Reflux Esophagitis Rats.

Most Relevant Research

We evaluated how Curcumae Longae Rhizoma extract, which contains the well-known compound curcumin, influences reflux conditions in rats suffering from acute reflux esophagitis (ARE). Through a series of experiments, we were able to measure various antioxidant and inflammatory markers, providing insight into how this natural treatment helps manage reflux symptoms.

To investigate the protective effects of this turmeric extract, we induced ARE in Sprague-Dawley rats and administered the extract prior to the onset of reflux. Remarkably, we found that the inclusion of the turmeric extract significantly reduced tissue damage in the esophagus of the treated rats. Moreover, the levels of harmful substances typically associated with inflammation and oxidative stress, such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST), were notably decreased.

Additionally, our results indicated that the turmeric extract helped promote antioxidant activity while suppressing pro-inflammatory proteins. This suggests that Curcumae Longae Rhizoma may be a promising therapeutic option for managing reflux-related conditions effectively. Overall, we were encouraged by the findings that indicate its potential role in both prevention and treatment of acute reflux esophagitis.

Maintains stomach relief

Most Useful Review

Outstanding for acid reflux. I have been using this product for over six years, taking two capsules per day simultaneously. It is the only remedy that keeps my acid reflux in check. Anytime I stop taking it, within 2 to 3 days, my reflux returns relentlessly, regardless of my diet (I avoid coffee, soda, alcohol, orange juice, and acidic foods). After 20 years on prescription medication, which was unhelpful, I turned to this alternative. If you are weary of prescriptions and have stomach troubles, give this a try.

Arthritis

Curcumin reduces osteoarthritis severity

Curcumin alleviates osteoarthritis in mice by suppressing osteoclastogenesis in subchondral bone via inhibiting NF-κB/JNK signaling pathway.

Most Relevant Research

We investigated how curcumin, the active compound in turmeric, impacts osteoarthritis (OA) by focusing on its role in reducing the formation of bone-destroying cells called osteoclasts. In our research, we used a mouse model designed to mimic OA by destabilizing the medial meniscus, allowing us to measure the effects of curcumin on joint health.

Our study included three groups of male mice: those who received a vehicle treatment after their surgery, those with OA but also receiving the vehicle, and those with OA that were treated with curcumin. Over the course of eight weeks, we monitored the mice's cartilage and bone structure, looking for any changes.

We found that curcumin significantly suppressed osteoclast formation and bone resorption without harming the cells, suggesting it may be a promising treatment to alleviate arthritis symptoms. Specifically, curcumin inhibited the activation of important signaling pathways that promote osteoclast formation and cartilage degradation. This suggests a new and exciting approach for treating osteoarthritis, offering hope for better management of this chronic condition.

9.5

Pain relief

Most Useful Review

Fantastic supplement for arthritis sufferers! I have rheumatoid arthritis in my wrists and knees. I've taken Jarrow and Now brands Curcumin for months, which has significantly reduced my pain and flare-ups. I recently tried the Bio form of Curcumin, and it felt miraculous. Post-taking, I experienced a surge in energy, but beware of overdoing it as I did. Thanks iHerb for the great prices and fresh supplements.

Chest Pain

Joint pain has been significantly reduced.

High Cholesterol

Turmeric improves cholesterol levels

Based on 14 Researches

Effects of curcumin/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.

Most Relevant Research

We aimed to understand how turmeric, specifically its active compound curcumin, affects cholesterol levels in the body. After searching several online databases and analyzing 64 randomized clinical trials, we found that turmeric supplementation can lead to noticeable improvements in key cholesterol metrics.

Specifically, we observed significant reductions in total cholesterol, triglycerides, and low-density lipoprotein cholesterol (often referred to as "bad" cholesterol). Additionally, there was an increase in high-density lipoprotein cholesterol, known as "good" cholesterol. However, it's important to note that turmeric did not show considerable effects on related apolipoproteins, which are proteins that help carry cholesterol in the blood.

Although these results are promising, we must approach them with caution. The quality of evidence was assessed to be low and very low regarding these outcomes. This means that while turmeric supplementation does seem to help with certain cholesterol levels, more rigorous studies are needed to confirm these benefits and properly evaluate the overall efficacy.

8.3

Metabolic syndrome support

Most Useful Review

Curcumin lowers bad cholesterol, slows blood clot formation, and blocks inflammatory substances. Turmeric is excellent for reducing metabolic syndrome and preventing atherosclerosis.

Acne

Curcumin shows promise for acne

Based on 7 Researches

In vitro anti-propionibacterium activity by curcumin containing vesicle system.

Most Relevant Research

We investigated the potential of curcumin, a natural compound from turmeric, as an effective treatment for acne caused by Propionibacterium acnes. This bacterium can contribute to the development of inflammatory acne, especially when it grows excessively in hair follicles. Our goal was to create lipid-based vehicles to effectively deliver curcumin and see if it could inhibit the growth of this troublesome bacteria.

Using innovative testing methods, including bioluminescence assays, we evaluated how well our curcumin-infused vehicles performed against P. acnes. Additionally, we studied how much curcumin could accumulate in the skin using specialized diffusion cells and high-tech microscopy. The results were promising: we found that our lipid vehicles could accumulate an impressive amount of curcumin in the skin while significantly reducing the bacteria's growth.

Notably, curcumin showed discernible inhibitory effects at a concentration of just 0.43 µg/mL. Moreover, we confirmed through microscopy that the curcumin effectively formed a reservoir in the skin, enabling longer-lasting effects against acne. Overall, these findings suggest that curcumin-based vehicles, particularly when mixed with lauric acid, could serve as a promising new option for treating acne vulgaris.

Helps with inflammation

Most Useful Review

This is a fantastic product that everyone could benefit from due to its wonderful properties. It almost acts like a blood purifier, assisting with inflammation and even addressing acne on the skin!

Anxiety

Curcumin shows promise for anxiety

Based on 10 Researches

Effect of curcumin supplementation on symptoms of anxiety: A systematic review and meta-analysis of randomized controlled trials.

Most Relevant Research

We explored the potential of curcumin, a natural compound found in turmeric, as a treatment for anxiety. Through a thorough analysis of eight randomized controlled trials that included 567 participants, we aimed to determine whether curcumin could effectively alleviate anxiety symptoms.

The results were promising. The analysis indicated a significant improvement in anxiety symptoms among those who took curcumin, with a standardized mean difference of -1.56. This suggests that curcumin may lead to a noticeable reduction in anxiety levels. However, it’s important to note that the studies included were limited in number, and the variety in their designs contributed to considerable variation in outcomes.

While we found indications that curcumin may offer benefits for individuals dealing with anxiety, we also recognize the need for further high-quality research to solidify these findings. Until more comprehensive studies are conducted, it's crucial to approach curcumin as a potential supplementary treatment, rather than a standalone solution for anxiety disorders.

8.8

Curbing anxiety

Most Useful Review

I love using Curcumin as part of my daily routine to reduce inflammation and help with baseline anxiety. It's easy to incorporate, and I haven't noticed any negative side effects.

Chemotherapy

Eases chemotherapy side effects

Most Useful Review

Excellent. Curcumin Extract is one of the best anti-inflammatory products available, derived from the Turmeric Plant. This herb is highly recommended for cancer patients undergoing chemotherapy. It helps to alleviate the effects of chemotherapy drugs that adversely affect the immune system. I trust this reputable brand for quality products, and I will continue purchasing them without exception.

Hypothyroidism

Curcumin aids cognitive function

Based on 9 Researches

The effects of curcumin in learning and memory impairment associated with hypothyroidism in juvenile rats: the role of nitric oxide, oxidative stress, and brain-derived neurotrophic factor.

Most Relevant Research

We aimed to explore how curcumin, a natural compound found in turmeric, might influence cognitive challenges related to hypothyroidism in young rats. In this study, juvenile rats were split into several groups, with one group receiving hypothyroidism-inducing treatment while others were supplemented with varying doses of curcumin over six weeks.

The findings revealed some intriguing outcomes. In the hypothyroid group, rats struggled significantly in learning tasks compared to their healthy counterparts. They took longer to find hidden platforms in a water maze and spent less time in the desired areas during memory tests, indicating noticeable cognitive impairment. However, after curcumin treatment, the performance of these hypothyroid rats improved in both maze and avoidance tests.

Moreover, curcumin appeared to reduce markers of oxidative stress and increased the levels of important antioxidants in the brain. It also boosted the production of brain-derived neurotrophic factor (BDNF), which is crucial for learning and memory. This suggests that curcumin may help protect against some cognitive decline associated with hypothyroidism by tackling oxidative damage and enhancing essential neurotrophic support.

8.3

Control inflammation

Most Useful Review

Using this to chelate ferritin and lower inflammation from Hashimoto's. As I have Hashimoto's thyroiditis, this specific curcumin offers benefits due to its lack of bioprene. Hashimoto's is an autoimmune condition that inflames and attacks the thyroid, leading to hypothyroidism. If you have high ferritin, it could suggest an underlying infection needing attention. I have found this curcumin helpful in managing ferritin levels and controlling my inflammation while on a balanced diet. The AIP diet significantly improved my symptoms, and I recommend joining support groups for further guidance.

Migraine

Nano-curcumin reduces IL-17 levels

The effects of nano-curcumin supplementation on Th1/Th17 balance in migraine patients: A randomized controlled clinical trial.

Most Relevant Research

We conducted a study to explore how nano-curcumin, a special formulation of turmeric, influences the balance of immune proteins associated with migraines. By randomly assigning forty participants with episodic migraines to receive either an 80 mg dose of nano-curcumin or a placebo for two months, we ensured that our findings would be robust and reliable.

Our primary focus was on two key proteins: interferon gamma (IFN-γ) and interleukin-17 (IL-17). These proteins play significant roles in immune responses and are implicated in migraine pathophysiology. Using advanced techniques like real-time PCR and ELISA, we measured the levels of these proteins in our participants' blood.

The results were promising; we noted a significant decrease in the levels and gene expression of IL-17 in the group taking nano-curcumin compared to the placebo group. However, it’s important to mention that we found no significant differences in the levels of IFN-γ between the groups.

Overall, our findings suggest that nano-curcumin supplementation may provide beneficial effects for migraine patients by specifically targeting IL-17, which could lead to new approaches for managing migraine symptoms going forward.

9.5

Significant pain reduction

Most Useful Review

This high-quality curcumin capsule is excellent. I only need one a day, even with moderate to severe ME/CFS. It remarkably reduces my overall pain, including the intensity of my migraines, improves cognitive function, and alleviates autonomic problems. It's fantastic, and much cheaper here than elsewhere.

Neuropathy

Reverse neuropathy effects

Most Useful Review

This product significantly aids in reversing my neuropathy. I must note that it causes temporary tinnitus, especially when taken with piperine, but its benefits in reversing neuropathy are undeniable.

Psoriasis

Curcumin nanogels show psoriasis promise

Curcumin Nanogel Preparations: A Promising Alternative for Psoriasis Treatment.

Most Relevant Research

We explored the potential of curcumin, a natural compound derived from turmeric, as a treatment for psoriasis. Known for its anti-inflammatory properties, curcumin has been used in traditional medicine for centuries and is now being recognized for its role in modern therapeutic approaches. Psoriasis, a chronic skin condition marked by red, scaly patches, can be challenging to manage, making the search for effective treatments crucial.

The study highlighted curcumin's ability to inhibit specific enzymes and proteins that contribute to the inflammation and proliferation of skin cells associated with psoriasis. Interestingly, curcumin is being formulated into nanogels—small, crosslinked hydrogels that enhance the delivery of the compound. This nanogel preparation not only boosts the solubility and stability of curcumin but also increases its bioavailability, meaning we may need lower doses to achieve the desired results.

Ultimately, we found that curcumin nanogels present a promising alternative to traditional psoriasis treatments. They offer a potential pathway to more effective and safer treatment options. However, it's essential to emphasize that more research is necessary to fully understand how well these curcumin nanogels work in humans before they become a standard part of psoriasis care.

8.8

Eczema and psoriasis cleared

Most Useful Review

The BEST supplement! After researching, I chose this NOW brand due to its good reputation and reasonable price. After six weeks of taking one capsule daily, my eczema has cleared up completely, as have the itchy psoriasis spots on my scalp. I attribute these improvements to this supplement and intend to keep using it.

Stroke

Curcumin aids stroke recovery

Curcumin protects against cerebral ischemia-reperfusion injury in rats by attenuating oxidative stress and inflammation: A meta-analysis and mechanism exploration.

Most Relevant Research

We explored how curcumin, a compound found in turmeric, may help protect the brain from damage caused by stroke. The study we reviewed involved an in-depth analysis, aggregating data from various experiments on rats that experienced cerebral ischemia-reperfusion injury (CIRI), which mimics the conditions of a stroke.

Our findings indicated that curcumin significantly improved neurological outcomes in these animals. We observed a marked reduction in neurological deficit scores, infarct volumes, and brain water content after curcumin treatment. This suggests that curcumin not only helps the brain recover but might also reduce damage during a stroke.

Additionally, the analysis revealed that curcumin enhances the body’s antioxidant defenses while decreasing harmful inflammatory markers. We found increases in beneficial substances like superoxide dismutase and glutathione, alongside decreases in reactive oxygen species and pro-inflammatory cytokines.

Subgroup analyses hinted that the effectiveness of curcumin could vary based on the dosage used. Overall, our exploration supports the potential of curcumin as a neuroprotective agent in stroke treatment, though further research is needed to solidify its practical applications in stroke therapy.

8.8

Offsetting drug effects

Most Useful Review

It seems to be helping. Although this curcumin wasn't top-rated, it's been effective. We’re using it to combat the adverse side effects of the medications my mother takes for a-fib and stroke prevention. While we are playing catch-up, it appears to enhance her engagement and interaction.

Pots

Benefits inflammation control

Most Useful Review

I use this to chelate ferritin and reduce inflammation from Hashimoto's thyroditis. This curcumin variant contains no bioprene, which is advised against for autoimmune conditions. It's crucial to manage your diet to control inflammation linked to these ailments. This product aids in handling inflammation while chelating excess ferritin, which may signal underlying infections. Following an autoimmune protocol has greatly improved my symptoms, which were alleviated after adhering strictly to dietary changes.

Headache

Curcumin improves migraine symptoms

Based on 8 Researches

Effects of Curcumin Supplementation on Clinical Features and Inflammation, in Migraine Patients: A Double-Blind Controlled, Placebo Randomized Clinical Trial.

Most Relevant Research

We conducted a thoughtful investigation into the effects of curcumin, a natural compound found in turmeric, on migraine sufferers. This study involved 44 women with migraines, who were randomly assigned to receive either 500 mg of curcumin twice a day or a placebo for eight weeks. The team measured various factors, including the severity, duration, and frequency of headaches, as well as specific inflammation markers in the body.

After the eight-week period, we observed noticeable improvements in the group receiving curcumin. Compared to the placebo, participants taking curcumin reported significant reductions in pain severity and headache duration. While there was a slight improvement in how often headaches struck, it didn't reach a level of statistical significance.

Moreover, curcumin supplementation also appeared to lower levels of two important inflammatory markers related to migraines: calcitonin gene-related peptide (CGRP) and interleukin-6 (IL-6). We didn't see any significant changes in body weight or composition between the groups, indicating that the effects were primarily linked to curcumin's properties rather than any other lifestyle changes.

Overall, our findings suggest that curcumin may serve as an effective, natural remedy for managing migraine symptoms, largely due to its anti-inflammatory benefits.

6.3

Headaches resolved

Most Useful Review

This supplement eliminated my headaches, but I developed constipation. I had a torn ligament in my lower back that triggered headaches. After trying this, my headaches disappeared, although I suspect it interacts with my thyroid medicine. It’s unfortunate because it was very effective. I’m now trying something else that seems to be helping as well, despite some issues.

Diarrhea

Curcumin alleviates diarrhea inflammation

Based on 11 Researches

Protective effects of curcumin against rat intestinal inflammation‑related motility disorders.

Most Relevant Research

In a recent study, we examined how curcumin, a component from the ginger family known for its anti-inflammatory properties, affects diarrhea in rats facing intestinal inflammation. We utilized a model involving Sprague-Dawley rats to induce conditions resembling diarrhea through the instillation of acetic acid.

Our findings highlighted that curcumin played a significant role in reversing the increase of pro-inflammatory cytokines, such as IL-1β and TNF-α, through the inhibition of the NF-κB pathway. Notably, we observed that curcumin effectively reduced myosin light chain (MLC) phosphorylation in the jejunum of rats experiencing diarrhea. This reduction was closely linked to improved motility in the context of inflammation.

Additionally, the study revealed that curcumin not only mitigated hypermotility related to diarrhea but also positively influenced inflammatory responses. This indicates that curcumin may hold therapeutic potential for managing intestinal inflammation-related motility disorders like diarrhea. Overall, our research suggests that incorporating curcumin could offer an effective strategy for those struggling with this condition.

Negative effects experienced

Most Useful Review

This product does not seem to digest properly and only seems to significantly affect my intestines. I find many bright orange chunks intact after it causes diarrhoea, gas, and nausea. I recommend avoiding this product.

Nausea