' 
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
< 1%**
Vitamin A (from Retinyl Palmitate and Cod Liver Oil)
750 mcg
83%
Vitamin D3 (from Cholecalciferol and Cod Liver Oil)
6.75 mcg (270 IU)
34%
Cod Liver Oil
650 mg
†
The product is found useful for the following medical conditions
Bone Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.8
9.5
Pain and inflammation relief
Most Useful Review
This product is fantastic! It's affordable and treats many issues, including SAD, depression, aches, and displaced spinal discs. It relieved my bone pain, helped me heal an injured ligament, and improved my energy levels while ensuring I don't suffer from winter blahs.
Cardiovascular Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7
USERS' SCORE
Good
Based on 12 Reviews
8.6
9
We examined how cod liver oil might influence cardiovascular disease, particularly in relation to atherogenesis and thrombogenesis. Previous observations suggested that eating marine fish can lower the risk of ischemic heart disease. However, the universal recommendation for fish oil as a supplement remains uncertain due to potential side effects associated with high dosages.
Our research revealed that while fish oil lowers cholesterol and triglyceride levels, it can also increase levels of low-density lipoprotein, which raises concerns about free radical generation and bleeding. Interestingly, moderate intake of marine fish has shown protective effects against heart disease without significantly changing traditional measurements like cholesterol levels or blood clotting times.
In a controlled study with swine, we noted that adding cod liver oil to a high-fat diet resulted in fewer monocyte adhesions and platelet clumps in critical heart arteries, suggesting that it plays a role in reducing clotting risks. To delve deeper into the mechanisms, we conducted an in vitro experiment where we treated endothelial cells with varying fatty acids.
Among these, only eicosapentaenoic acid (EPA) stood out in diminishing the binding of human monocytes to the endothelial cells, especially when applied within a specific timeframe after stimulation. Moreover, we found that EPA decreased the expression of certain adhesion molecules on endothelial cells following inflammatory stimulation.
Overall, our findings suggest that cod liver oil could be a potentially valuable addition to heart health strategies, particularly due to its unique ability to influence blood vessel interactions without significant adverse effects.
Our research revealed that while fish oil lowers cholesterol and triglyceride levels, it can also increase levels of low-density lipoprotein, which raises concerns about free radical generation and bleeding. Interestingly, moderate intake of marine fish has shown protective effects against heart disease without significantly changing traditional measurements like cholesterol levels or blood clotting times.
In a controlled study with swine, we noted that adding cod liver oil to a high-fat diet resulted in fewer monocyte adhesions and platelet clumps in critical heart arteries, suggesting that it plays a role in reducing clotting risks. To delve deeper into the mechanisms, we conducted an in vitro experiment where we treated endothelial cells with varying fatty acids.
Among these, only eicosapentaenoic acid (EPA) stood out in diminishing the binding of human monocytes to the endothelial cells, especially when applied within a specific timeframe after stimulation. Moreover, we found that EPA decreased the expression of certain adhesion molecules on endothelial cells following inflammatory stimulation.
Overall, our findings suggest that cod liver oil could be a potentially valuable addition to heart health strategies, particularly due to its unique ability to influence blood vessel interactions without significant adverse effects.
9.5
Relieves headaches
Most Useful Review
Omega 3 is essential for cardiovascular and nervous systems. Following Irina’s recommendation, I experienced significant benefits. My headaches and joint crunch have disappeared. I'm excited to continue using it!
Anxiety
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.6
9
CYP11A1, Autism Symptoms, Vitamin D3
Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention.
Most Relevant Research
We explored how overexpression of the CYP11A1 enzyme in the placenta can impact offspring and potentially lead to autism-like behaviors, particularly focusing on anxiety. Using a specialized murine model, we looked closely at how this genetic change affected social interactions and anxiety levels in the mice.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
9.5
Reduced panic attacks
Most Useful Review
Great supplement for anxiety and panic attack prevention. I've taken cod liver tablets daily for over six months with my first meal, and they have greatly reduced my panic and anxiety attacks.
Autoimmune Disorder
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Vitamin D3 modulates autoimmune response
Vitamin D3 attenuates autoimmune thyroiditis by regulating Th17/Treg cell differentiation via YAP/JAK1/STAT1 axis.
Most Relevant Research
We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
8.3
Supports thyroid health
Most Useful Review
Vitamin A in the form of retinol palmitate is ideal for absorbing beta-carotene, along with vitamins D and E. Its role in thyroid health is critical, as deficiency is linked to autoimmune disorder (AIT). Vitamin A can lower TSH levels and protect the thyroid, even with iodine deficiency. In hypothyroidism, it's important to replenish vitamin A as it is hard to obtain from plant sources. I take one capsule daily; it has been helpful for my health.
Heart Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.1
USERS' SCORE
Good
Based on 24 Reviews
8.5
9
Cod liver oil aids heart health
Cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats.
Most Relevant Research
We delved into how cod liver oil (CLO) influences heart health, especially in the context of diabetes. Using a study with streptozotocin (STZ)-induced diabetic rats, we treated them with CLO and monitored various cardiovascular metrics over 12 weeks. What we found was quite telling: untreated diabetic rats faced significant increases in blood sugar and harmful lipid levels, while those receiving CLO showed improved weight gain and complete prevention of lipid problems.
Moreover, the study revealed that CLO-treated rats exhibited healthier blood vessel responses and heart function. For instance, we observed that CLO effectively corrected some vasoconstriction issues and improved heart rhythm responses that were otherwise diminished in diabetic rats. The treatment also helped preserve the structural integrity of heart tissue, which often suffers in diabetes.
Overall, this research strongly suggests that cod liver oil can be a valuable supplement for mitigating heart disease risks associated with diabetes. With its rich omega-3 fatty acids and antioxidants, CLO appears to play a protective role in maintaining cardiovascular health in diabetic settings.
Moreover, the study revealed that CLO-treated rats exhibited healthier blood vessel responses and heart function. For instance, we observed that CLO effectively corrected some vasoconstriction issues and improved heart rhythm responses that were otherwise diminished in diabetic rats. The treatment also helped preserve the structural integrity of heart tissue, which often suffers in diabetes.
Overall, this research strongly suggests that cod liver oil can be a valuable supplement for mitigating heart disease risks associated with diabetes. With its rich omega-3 fatty acids and antioxidants, CLO appears to play a protective role in maintaining cardiovascular health in diabetic settings.
7
Promotes heart health
Most Useful Review
Great Cod Liver Oil 650mg is an excellent dosage. It's beneficial for heart disease and general health.
Hypothyroidism
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Vitamin A benefits thyroid function
The effect of vitamin A supplementation on thyroid function in premenopausal women.
Most Relevant Research
We conducted a thorough investigation into how vitamin A supplementation might impact thyroid function, particularly focusing on women who are premenopausal and have varying body weights. Our study was a robust, four-month randomized controlled trial involving 84 healthy women aged 17 to 50. Among them, 56 women were classified as obese, while 28 fell into the nonobese category.
Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.
Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.
Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.
Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.
Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.
Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.
8.3
Thyroid support
Most Useful Review
Vitamin A in retinol palmitate form aids the absorption of beta-carotene, alongside vitamins D and E. Research shows that vitamin A deficiency in hypothyroidism links to autoimmune thyroiditis and low T3 levels. It protects the thyroid even with iodine deficiency. Since it’s hard to replenish vitamin A from plant sources, I take one capsule daily.
Back Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 1 Review
8.5
9
Vitamin D3 improves back pain
Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial.
Most Relevant Research
We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
8.5
Effective for inflammation
Most Useful Review
Love this product. When I skip taking it for a couple of days, I can feel the aches and pains returning.
Bloating
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 1 Review
8.5
9
Calcium D3 reduces bloating
Calcium vitamin D3 supplementation in clinical practice: side effect and satisfaction.
Most Relevant Research
We explored the effectiveness of OsteoCalVitFort, a supplement combining 500 mg of calcium and 400 IU of vitamin D3, focusing specifically on its impact on bloating. The study involved 186 participants aged 18 to 65 years, who took two tablets daily—one after breakfast and one after dinner.
Through follow-up phone calls, we gathered information about any side effects and the overall satisfaction with the supplement. Notably, we observed a significant reduction in bloating, with the rate decreasing from 12.5% before taking the supplement to just 0.6% after. This impressive drop highlights the potential benefits of vitamin D3 in alleviating bloating discomfort.
Overall, the findings suggest that OsteoCalVitFort is not only effective but also well-received by users, with 94% reporting satisfaction with their experience. Importantly, we noted that no significant adverse effects were reported, setting OsteoCalVitFort apart from other supplements often linked with gastrointestinal issues.
Through follow-up phone calls, we gathered information about any side effects and the overall satisfaction with the supplement. Notably, we observed a significant reduction in bloating, with the rate decreasing from 12.5% before taking the supplement to just 0.6% after. This impressive drop highlights the potential benefits of vitamin D3 in alleviating bloating discomfort.
Overall, the findings suggest that OsteoCalVitFort is not only effective but also well-received by users, with 94% reporting satisfaction with their experience. Importantly, we noted that no significant adverse effects were reported, setting OsteoCalVitFort apart from other supplements often linked with gastrointestinal issues.
8.8
Improves skin and bloating
Most Useful Review
This really seems effective. I noticed improvements with skin, aches, and bloating. Vitamin A is key here, and it appears that requirements vary widely. If you're lacking it, this could help.
Flu
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.5
USERS' SCORE
Good
Based on 1 Review
8.5
8
Vitamin D3 reduces flu incidence
Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren.
Most Relevant Research
We carried out a study to investigate whether vitamin D3 supplements could help prevent seasonal influenza A in schoolchildren. Our approach involved a randomized, double-blind, placebo-controlled trial conducted from December 2008 to March 2009.
This ensured that neither the participants nor the researchers knew who was receiving the vitamin D3 or the placebo, making our findings more reliable. During the trial, we provided 1200 IU of vitamin D3 daily to one group while the other received a placebo.
The results were promising; we found that only 10.8% of the children taking vitamin D3 contracted influenza A, compared to 18.6% in the placebo group. This reduced incidence led us to a relative risk of 0.58, suggesting that vitamin D3 supplementation may lower the chances of getting the flu.
Interestingly, we noticed the most significant benefits among children who hadn’t been taking any other vitamin D supplements and those who began nursery school after age three. Additionally, in children with a past asthma diagnosis, vitamin D3 seemed to dramatically reduce asthma attacks.
Overall, our findings indicate that taking vitamin D3 in the winter could be beneficial for schoolchildren, especially for certain groups. We believe this study adds valuable insights into preventive health measures against influenza A.
This ensured that neither the participants nor the researchers knew who was receiving the vitamin D3 or the placebo, making our findings more reliable. During the trial, we provided 1200 IU of vitamin D3 daily to one group while the other received a placebo.
The results were promising; we found that only 10.8% of the children taking vitamin D3 contracted influenza A, compared to 18.6% in the placebo group. This reduced incidence led us to a relative risk of 0.58, suggesting that vitamin D3 supplementation may lower the chances of getting the flu.
Interestingly, we noticed the most significant benefits among children who hadn’t been taking any other vitamin D supplements and those who began nursery school after age three. Additionally, in children with a past asthma diagnosis, vitamin D3 seemed to dramatically reduce asthma attacks.
Overall, our findings indicate that taking vitamin D3 in the winter could be beneficial for schoolchildren, especially for certain groups. We believe this study adds valuable insights into preventive health measures against influenza A.
8.3
Flu prevention
Most Useful Review
Product was accurate. We’ve been taking the capsules for about a month and can already tell the difference. We were fortunate not to get the flu, and I’m sure it’s due to the Cod Liver Oil.
High Cholesterol
SCIENTIFIC SCORE
Questionable
Based on 27 Researches
6.7
USERS' SCORE
Good
Based on 19 Reviews
8.4
9
Vitamin D3 lowers cholesterol levels
Vitamin D Supplementation Reduces Hyperlipidemia and Improves Bone Mass in Pediatric Obesity.
Most Relevant Research
We investigated how vitamin D3 supplements impact cholesterol levels in pediatric patients suffering from obesity. The study involved 723 children over two years, with 283 receiving vitamin D3 and 440 on a placebo.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
10
Healthy skin
Most Useful Review
This product is excellent and has greatly benefited me. My skin, hair, and nails are healthier, and my good cholesterol has increased. The quantity is large, meaning it lasts a long time, and the price is very affordable. I highly recommend it.
Nausea
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 1 Review
8.3
8
Vitamin A reduces pregnancy nausea
Vitamin A or beta-carotene supplementation reduces symptoms of illness in pregnant and lactating Nepali women.
Most Relevant Research
We conducted a double-masked, placebo-controlled trial involving 15,832 Nepali women to explore how vitamin A and beta-carotene supplementation affects pregnancy-related nausea and overall illness symptoms. Our observations showed that while there was no noticeable impact during the early stages of pregnancy, vitamin A supplementation made a significant difference in late pregnancy.
Specifically, we found that women who received vitamin A experienced a reduction in nausea. Additionally, symptoms such as faintness and night blindness were also less prevalent in those women. Beta-carotene supplementation did not yield the same benefits for nausea, highlighting the unique role of vitamin A in managing these symptoms.
Moreover, supplementation with vitamin A contributed to a shorter labor duration, which is promising for expectant mothers. It also helped reduce the postpartum risks of conditions like night blindness and loose stools. Overall, our findings indicate that ensuring adequate vitamin A intake can be important for improving reproductive health in women, particularly in areas with limited healthcare access.
Specifically, we found that women who received vitamin A experienced a reduction in nausea. Additionally, symptoms such as faintness and night blindness were also less prevalent in those women. Beta-carotene supplementation did not yield the same benefits for nausea, highlighting the unique role of vitamin A in managing these symptoms.
Moreover, supplementation with vitamin A contributed to a shorter labor duration, which is promising for expectant mothers. It also helped reduce the postpartum risks of conditions like night blindness and loose stools. Overall, our findings indicate that ensuring adequate vitamin A intake can be important for improving reproductive health in women, particularly in areas with limited healthcare access.
5.8
Zinc deficiency impact
Most Useful Review
May cause nausea. I gave this a good rating as it is likely due to my zinc deficiency that I feel nauseated when taking these (even with food).
Heart Attack
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.1
USERS' SCORE
Good
Based on 14 Reviews
8.2
9
Calcitriol aids heart recovery
Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction.
Most Relevant Research
We examined the impact of calcitriol, the active form of vitamin D, on heart attack recovery using a mouse model of myocardial infarction (MI). In our study, we treated mice that had suffered a MI with calcitriol and observed promising results.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
7
Good for the heart
Most Useful Review
Great Cod Liver Oil 650mg is an excellent dose. It’s very good for heart health and overall well-being.
Liver Disease
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8.1
USERS' SCORE
Good
Based on 4 Reviews
8.2
9
Vitamin D3 aids liver health
Effects of vitamin D supplementation on the glycaemic indices, lipid profile and liver function tests in patients with cirrhosis: a double-blind randomised controlled trial.
Most Relevant Research
We aimed to explore how vitamin D3 supplementation affects liver disease, specifically in patients with cirrhosis. In a thorough double-blind, randomized controlled trial involving 60 participants, we offered patients either a weekly dose of 50,000 IU of vitamin D or a placebo for 12 weeks. Our goal was to assess various health indicators, including serum vitamin D levels, blood glucose measures, and liver function tests.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
8.8
Cholesterol improvement
Most Useful Review
Cholesterol was raised. With my doctor’s guidance, we enhanced my nutrition, aerobic exercise, and dietary supplements. I took unrefined vegetable oils, lecithin, omega-3, sorbents, probiotics, antioxidants, and cod liver oil, prescribed as iHerb Now Foods Cod Liver Oil (650 mg). I consumed 2 capsules twice daily. The capsules are large, reasonably priced, and I liked the product. Cholesterol began to decline after a month.
Blood Clot
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.1
USERS' SCORE
Good
Based on 3 Reviews
8
9.5
Cod liver oil prevents clotting
Prevention of platelet aggregation by dietary polyunsaturated fatty acids in the biodegradable polyurethane vascular prosthesis: an experimental model in pigs.
Most Relevant Research
In a fascinating experiment involving young pigs, we observed how cod liver oil can prevent blood clotting in biodegradable vascular prostheses. The study included a total of 25 pigs, with 15 of them fed cod liver oil alongside their regular diets. They were compared against 10 control pigs that weren’t given any additional fatty acids.
Over the course of several months, we performed imaging tests and found that all the control implants were completely thrombosed by day 30. In stark contrast, the pigs who received the cod liver oil showed 100% patency—or openness—of their grafts even at later stages of the study.
Upon retrieval, 7 out of 9 grafts in the cod liver oil group remained patent, indicating that the fish oil's rich content of n-3 polyunsaturated fatty acids could significantly modify lipid metabolism. This modification appears to prevent the clumping of platelets, which is a crucial factor in blood clot formation.
Tissue analysis revealed that the patent grafts were well-integrated with tissue resembling natural blood vessel lining, complete with muscle cells that indicate healthy growth. This study clearly shows that a diet enriched with essential fatty acids can play a substantial role in preventing thrombosis in biodegradable vascular prostheses. The combination of our innovative materials and dietary strategies could pave the way for better heart surgery outcomes in the future.
Over the course of several months, we performed imaging tests and found that all the control implants were completely thrombosed by day 30. In stark contrast, the pigs who received the cod liver oil showed 100% patency—or openness—of their grafts even at later stages of the study.
Upon retrieval, 7 out of 9 grafts in the cod liver oil group remained patent, indicating that the fish oil's rich content of n-3 polyunsaturated fatty acids could significantly modify lipid metabolism. This modification appears to prevent the clumping of platelets, which is a crucial factor in blood clot formation.
Tissue analysis revealed that the patent grafts were well-integrated with tissue resembling natural blood vessel lining, complete with muscle cells that indicate healthy growth. This study clearly shows that a diet enriched with essential fatty acids can play a substantial role in preventing thrombosis in biodegradable vascular prostheses. The combination of our innovative materials and dietary strategies could pave the way for better heart surgery outcomes in the future.
7.5
Improved heart health
Most Useful Review
This omega improves blood vessel and heart health, effectively lowering cholesterol levels. The ingredients and quality are excellent.
