' 
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
The product is found useful for the following medical conditions
Acne
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
USERS' SCORE
Good
Based on 7 Reviews
8.8
9
Docosahexaenoic acid reduces acne risk
The causal association between polyunsaturated fatty acids and acne: A two-sample Mendelian randomization study.
Most Relevant Research
We investigated the relationship between docosahexaenoic acid (DHA), a type of polyunsaturated fatty acid (PUFA), and the occurrence of acne. Using a method called Mendelian randomization, we looked at how genetic variations associated with DHA might influence acne development in large groups of participants, including over 115,000 individuals from the UK and nearly 364,000 of Finnish ancestry.
Our findings revealed that higher levels of DHA are actually linked to a lower risk of developing acne. Specifically, we found that a significant increase in DHA levels or its proportion compared to total fatty acids corresponded with a reduced likelihood of acne. In contrast, higher levels of linoleic acid (LA), another type of PUFA, were associated with an increased acne risk.
This suggests that balancing our intake of these fatty acids might be important for skin health. Notably, the results pointed towards a genetic connection involving the FADS1 gene, which appears to play a role in how these fatty acids affect our skin.
In conclusion, increasing DHA could be beneficial in protecting against acne, while excessive linoleic acid might have the opposite effect. Overall, our study highlights the importance of these fatty acids in understanding acne risk better.
Our findings revealed that higher levels of DHA are actually linked to a lower risk of developing acne. Specifically, we found that a significant increase in DHA levels or its proportion compared to total fatty acids corresponded with a reduced likelihood of acne. In contrast, higher levels of linoleic acid (LA), another type of PUFA, were associated with an increased acne risk.
This suggests that balancing our intake of these fatty acids might be important for skin health. Notably, the results pointed towards a genetic connection involving the FADS1 gene, which appears to play a role in how these fatty acids affect our skin.
In conclusion, increasing DHA could be beneficial in protecting against acne, while excessive linoleic acid might have the opposite effect. Overall, our study highlights the importance of these fatty acids in understanding acne risk better.
10
Smoother skin texture
Most Useful Review
I've been using this for three years now. My nails are less brittle, bruises fewer, and my skin is smoother, with peeling and acne now gone. I take three capsules daily and will keep using it.
Allergies
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.9
USERS' SCORE
Good
Based on 5 Reviews
8.8
8
Omega-3s and skin allergies
ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α.
Most Relevant Research
We uncovered intriguing insights into how eicosapentaenoic acid (EPA) and its metabolite, 12-hydroxyeicosapentaenoic acid (12-HEPE), play a role in managing allergic responses, particularly in the skin. Our study revealed that when mice consumed an omega-3 fatty acid-rich diet, 12-HEPE became a significant metabolite in their skin.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
9.5
Allergy improvement
Most Useful Review
Super Omega! This was recommended by my nutritionist. It’s well-tolerated, with no side effects. After a few days, my allergy symptoms vanished, and my dermatitis cleared up. My sleep improved and my joints are more flexible without the discomfort I previously experienced. The results were excellent and exceeded my expectations!
Alzheimer
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7
USERS' SCORE
Good
Based on 8 Reviews
8.8
9
DHA shows promise in Alzheimer's
Nose-to-brain delivery of DHA-loaded nanoemulsions: A promising approach against Alzheimer's disease.
Most Relevant Research
We investigated the potential benefits of docosahexaenoic acid (DHA) in fighting Alzheimer's disease (AD) through a novel intranasal administration method. By using a specially formulated nanoemulsion that protects DHA from oxidation, we aimed to enhance its delivery to the brain. In our study, we administered this DHA-rich nanoemulsion to J20 mice, a well-known transgenic model for AD.
The results were promising. After treatment, the mice showed notable improvements in their well-being and memory performance, which we measured through their ability to navigate spatial tasks. Additionally, we observed a significant reduction in harmful amyloid deposits, oxidative stress, and neuroinflammation within their brain tissues. This positive outcome could potentially stem from DHA's ability to affect specific processes in the brain, such as the inactivation of GSK3β, a kinase associated with AD.
Overall, our findings suggest that intranasal DHA treatment not only has therapeutic effects but may also modify the progression of Alzheimer's disease. Considering that DHA has already demonstrated safety in humans, we believe there is a strong case for conducting clinical trials to explore this approach further for Alzheimer's patients.
The results were promising. After treatment, the mice showed notable improvements in their well-being and memory performance, which we measured through their ability to navigate spatial tasks. Additionally, we observed a significant reduction in harmful amyloid deposits, oxidative stress, and neuroinflammation within their brain tissues. This positive outcome could potentially stem from DHA's ability to affect specific processes in the brain, such as the inactivation of GSK3β, a kinase associated with AD.
Overall, our findings suggest that intranasal DHA treatment not only has therapeutic effects but may also modify the progression of Alzheimer's disease. Considering that DHA has already demonstrated safety in humans, we believe there is a strong case for conducting clinical trials to explore this approach further for Alzheimer's patients.
9.5
Supports brain health
Most Useful Review
Excellent! DHA is vital for brain health, particularly for those with a family history of Alzheimer's. I appreciate this NOW product as it contains 500mg of DHA per capsule.
Anxiety
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.4
USERS' SCORE
Good
Based on 8 Reviews
8.8
8
DHA improves milk and reduces anxiety
DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring.
Most Relevant Research
We explored how supplementing obese mothers with docosahexaenoic acid (DHA) affects milk composition and the anxiety behavior of their offspring. In a study involving female Wistar rats, some were placed on a high-fat diet while others ate regular chow. We supplemented half of the mothers from one month before mating until they weaned their pups with DHA. The goal was to see if this supplementation could improve the quality of their milk and influence the anxiety levels of their babies.
Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.
Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.
Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.
Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.
9.5
Psychological relief
Most Useful Review
Remarkable effects! After rapid weight loss, I faced anxiety and panic attacks. Within a week of taking DHA, I felt normal again without any adverse symptoms. NOW's quality is outstanding and crucial for my health.
Back Pain
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.7
USERS' SCORE
Good
Based on 6 Reviews
8.8
9
Omega-3s reduce disc degeneration
Omega-3 Fatty Acid Supplementation Reduces Intervertebral Disc Degeneration.
Most Relevant Research
We aimed to find out how docosahexaenoic acid (DHA), a key omega-3 fatty acid, could affect intervertebral disc (IVD) degeneration, a common cause of lower back pain. In our study, we used a group of 12 rats, all of whom underwent a procedure to induce disc degeneration.
After the injury, half of the rats were given a daily supplement of omega-3 fatty acids, while the other half received only a sugar solution as control. Over the course of the study, we measured various outcomes related to inflammation and disc health.
We observed that the omega-3 group showed a significant reduction in blood markers associated with inflammation. Additionally, the results indicated that those receiving DHA were less affected by disc dehydration, and the tissue damage due to the induced injury was noticeably less severe in this group.
Overall, this suggests that increasing our intake of omega-3 fatty acids, like DHA, may offer protective effects against the degeneration of intervertebral discs and could potentially ease back pain related to this condition.
After the injury, half of the rats were given a daily supplement of omega-3 fatty acids, while the other half received only a sugar solution as control. Over the course of the study, we measured various outcomes related to inflammation and disc health.
We observed that the omega-3 group showed a significant reduction in blood markers associated with inflammation. Additionally, the results indicated that those receiving DHA were less affected by disc dehydration, and the tissue damage due to the induced injury was noticeably less severe in this group.
Overall, this suggests that increasing our intake of omega-3 fatty acids, like DHA, may offer protective effects against the degeneration of intervertebral discs and could potentially ease back pain related to this condition.
9.5
Improved back pain
Most Useful Review
DHA 500 (Omega 3) has greatly helped my memory! I ordered it at the start of July 2021, and it arrived in 10 days without fees. I take three capsules daily, one before each meal. After two months, my memory and focus have improved significantly, and my back pain seems to have disappeared, which I believe is due to this supplement.
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 15 Reviews
8.8
9.5
Eicosapentaenoic acid benefits CFS
Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes.
Most Relevant Research
We explored the potential benefits of eicosapentaenoic acid (EPA), an essential fatty acid, in treating chronic fatigue syndrome (CFS). A female patient with a six-year history of persistent CFS symptoms participated in the study, receiving a daily supplement rich in EPA.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
9.5
Fatigue decreased
Most Useful Review
Fatigue has diminished significantly! Just a month ago, I felt completely worn out after 20 hours, but now I hardly notice it. I highly recommend this, especially for mothers of multiple children. It truly helps in combating chronic fatigue syndrome!
Reflux
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.8
9.5
No reflux issues
Most Useful Review
DHA is an essential part of my diet and the best omega I have tried. It leaves no odour, doesn't cause reflux, and is safe from mercury. As a nutritionist, I highly recommend this product.
Autoimmune Disorder
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.6
USERS' SCORE
Good
Based on 6 Reviews
8.7
8
Eicosapentaenoic acid benefits MS
The therapeutic effect of PEGlated nanoliposome of pistachio unsaturated oils and its efficacy to attenuate inflammation in multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial phase I.
Most Relevant Research
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore the effects of PEGlated nanoliposome of pistachio unsaturated oils on inflammation in multiple sclerosis (MS). During the study, we treated MS patients with these nanoliposomes enriched with eicosapentaenoic acid, a type of omega-3 fatty acid known for its potential health benefits.
After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.
Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.
Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
9.5
Supports brain health
Most Useful Review
Omega 3 from Now has a high concentration of DHA, which I use according to the Nemechek protocol for brain recovery and to suppress inflammatory processes. DHA is crucial for brain function and cognitive development, especially as half of a mother's DHA reserve is passed to the child during pregnancy. Since DHA significantly exceeds EPA in the brain, it’s essential for mental nutrition. Now's Omega 3 is ideal for adults needing high DHA concentrations.
Cardiovascular Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.4
USERS' SCORE
Good
Based on 42 Reviews
8.7
9
EPA's role in diabetic heart health
Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy.
Most Relevant Research
We explored the impact of eicosapentaenoic acid (EPA), a nutrient known for its heart benefits, on diabetic cardiomyopathy (DC), a condition leading to heart failure. Our study focused on diabetic mice and revealed that EPA plays a protective role against DC, particularly by reducing harmful M1-polarized macrophages in the heart.
In our experiments, we found that EPA not only reduces cardiomyocyte injury caused by M1-polarized macrophages but also encourages a shift in macrophages' behavior from M1 to a protective Mox state—not M2. This shift is crucial because Mox macrophages help mitigate the damage inflicted by their M1 counterparts.
We identified heme oxygenase 1 (HO-1) as a key player in maintaining the Mox phenotype. EPA promotes HO-1, which helps curb macrophage M1 polarization and the resulting cardiomyocyte injury. Interestingly, our findings also showed that EPA fosters this protective Mox polarization in monocyte-derived macrophages from diabetic patients, suggesting a broader application for this treatment strategy.
Overall, our study highlights the potential of EPA as a novel approach to combat diabetic cardiomyopathy, emphasizing the importance of macrophage Mox polarization in maintaining heart health in diabetes.
In our experiments, we found that EPA not only reduces cardiomyocyte injury caused by M1-polarized macrophages but also encourages a shift in macrophages' behavior from M1 to a protective Mox state—not M2. This shift is crucial because Mox macrophages help mitigate the damage inflicted by their M1 counterparts.
We identified heme oxygenase 1 (HO-1) as a key player in maintaining the Mox phenotype. EPA promotes HO-1, which helps curb macrophage M1 polarization and the resulting cardiomyocyte injury. Interestingly, our findings also showed that EPA fosters this protective Mox polarization in monocyte-derived macrophages from diabetic patients, suggesting a broader application for this treatment strategy.
Overall, our study highlights the potential of EPA as a novel approach to combat diabetic cardiomyopathy, emphasizing the importance of macrophage Mox polarization in maintaining heart health in diabetes.
9.5
Good price
Most Useful Review
Great product at a good price! The capsules are large but easy to swallow, and the dosage is rich. Recommended for cardiovascular health, taken by the whole family for three months with a break.
Common Cold
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Researches
8
USERS' SCORE
Good
Based on 6 Reviews
8.7
8
DHA reduces infant cold symptoms
Prenatal docosahexaenoic acid supplementation and infant morbidity: randomized controlled trial.
Most Relevant Research
We conducted a double-blind randomized controlled trial to understand how prenatal supplementation of docosahexaenoic acid (DHA) might influence infant health, particularly concerning the common cold. Pregnant women were given either a daily dose of 400 mg of DHA or a placebo starting at 18 to 22 weeks of gestation until childbirth.
Caregivers then reported on their infants’ health at 1, 3, and 6 months, sharing details about common illness symptoms. We found that DHA supplementation appeared to reduce the number of colds at one month and also seemed to lessen the duration of various cold symptoms in infants. Specifically, infants in the DHA group experienced fewer cold symptoms and had shorter durations of cough and wheezing.
While the overall occurrence of specific illness symptoms was similar between the DHA and placebo groups, DHA did bring about noteworthy benefits. At 1 month, infants in the DHA group had a 26% shorter duration of cough and 30% shorter wheezing; however, they experienced a longer duration of rash.
Furthermore, by the time the infants reached 3 months, those whose mothers took DHA were ill for 14% less time overall. At 6 months, the DHA group showed significantly reduced durations of several illness indicators, although they did experience longer episodes of vomiting.
This study suggests that prenatal DHA not only seems to impact the occurrence of colds in children but may also play a role in the duration of symptoms over the first half-year of life.
Caregivers then reported on their infants’ health at 1, 3, and 6 months, sharing details about common illness symptoms. We found that DHA supplementation appeared to reduce the number of colds at one month and also seemed to lessen the duration of various cold symptoms in infants. Specifically, infants in the DHA group experienced fewer cold symptoms and had shorter durations of cough and wheezing.
While the overall occurrence of specific illness symptoms was similar between the DHA and placebo groups, DHA did bring about noteworthy benefits. At 1 month, infants in the DHA group had a 26% shorter duration of cough and 30% shorter wheezing; however, they experienced a longer duration of rash.
Furthermore, by the time the infants reached 3 months, those whose mothers took DHA were ill for 14% less time overall. At 6 months, the DHA group showed significantly reduced durations of several illness indicators, although they did experience longer episodes of vomiting.
This study suggests that prenatal DHA not only seems to impact the occurrence of colds in children but may also play a role in the duration of symptoms over the first half-year of life.
9.5
Common cold relief
Most Useful Review
We all take omega together as a family. We buy this brand specifically for adults as it offers a good dosage. Since we started taking omega and vitamin D3, we rarely get sick, or if we do, it’s in a milder form. One jar lasts us three months, and I believe the price and quality are good.
Constipation
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.7
10
Cured constipation
Most Useful Review
I purchased it to address my fish shortage diet, but it also unexpectedly cured my constipation. Despite eating less on my diet, I have experienced regular bowel movements, which I hadn’t managed daily before. This is remarkable, especially as previous remedies like Biofermin and Colac failed to help. The notion that its fat coating aids in easing the process may indeed be accurate.
Epilepsy
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8.7
2
No benefit observed in epilepsy
Effects of essential fatty acid supplementation in dogs with idiopathic epilepsy: a clinical trial.
Most Relevant Research
We conducted a study to investigate whether essential fatty acid supplementation, specifically eicosapentaenoic acid (EPA), could help control idiopathic epilepsy in dogs. This involved a carefully designed approach where fifteen dogs received a daily dose of purified Omega-3 oil for 12 weeks, followed by a 12-week placebo period using olive oil.
Throughout the study, dog owners diligently recorded seizure frequency and severity, along with any side effects that may have arisen. Despite hopes that these essential fatty acids would provide some benefit, the results were quite clear: we found no significant reduction in seizure frequency or severity for those dogs receiving the Omega-3 supplement compared to the placebo group.
These findings suggest that while EPA is a popular supplement often touted for various health benefits, it does not appear to have a positive effect on managing idiopathic epilepsy in dogs. This research can help pet owners make informed decisions about treatment options for their furry companions struggling with seizures.
Throughout the study, dog owners diligently recorded seizure frequency and severity, along with any side effects that may have arisen. Despite hopes that these essential fatty acids would provide some benefit, the results were quite clear: we found no significant reduction in seizure frequency or severity for those dogs receiving the Omega-3 supplement compared to the placebo group.
These findings suggest that while EPA is a popular supplement often touted for various health benefits, it does not appear to have a positive effect on managing idiopathic epilepsy in dogs. This research can help pet owners make informed decisions about treatment options for their furry companions struggling with seizures.
9.5
Great relief
Most Useful Review
EXCELLENT OMEGA AND THE PRICE IS VERY reasonable. I take omega due to severe epilepsy, which leads to dementia, and it significantly alleviates my condition.
Gastritis
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6.3
USERS' SCORE
Good
Based on 2 Reviews
8.7
8
DHA reduces H. pylori effects
Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid.
Most Relevant Research
We aimed to understand how docosahexaenoic acid (DHA) impacts the growth of Helicobacter pylori, a common bacteria linked to gastritis and other stomach disorders. Our research focused on how DHA influences bacterial adhesion to stomach cells and reduces inflammation associated with infection.
At concentrations of 100 µM, DHA effectively reduced H. pylori growth, while higher amounts of 250 µM or more led to irreversible effects on bacterial survival. We noted that DHA not only hindered bacterial growth but also decreased the bacteria's ability to attach to gastric epithelial cells. Moreover, we found that cells infected with DHA-treated H. pylori showed significantly lower levels of Interleukin-8 (IL-8), an inflammatory marker, alongside reductions in other inflammatory proteins.
Through our analysis, we discovered that DHA alters the outer membrane proteins of H. pylori, which are involved in its stress response and metabolism. These changes seem to contribute to lesser adhesion to stomach cells and a reduced inflammatory response. These findings suggest that DHA could be a beneficial alternative in managing H. pylori-related gastritis by targeting the bacteria and its effects on the stomach.
At concentrations of 100 µM, DHA effectively reduced H. pylori growth, while higher amounts of 250 µM or more led to irreversible effects on bacterial survival. We noted that DHA not only hindered bacterial growth but also decreased the bacteria's ability to attach to gastric epithelial cells. Moreover, we found that cells infected with DHA-treated H. pylori showed significantly lower levels of Interleukin-8 (IL-8), an inflammatory marker, alongside reductions in other inflammatory proteins.
Through our analysis, we discovered that DHA alters the outer membrane proteins of H. pylori, which are involved in its stress response and metabolism. These changes seem to contribute to lesser adhesion to stomach cells and a reduced inflammatory response. These findings suggest that DHA could be a beneficial alternative in managing H. pylori-related gastritis by targeting the bacteria and its effects on the stomach.
9.5
No discomfort experienced
Most Useful Review
Omega for those with stomach issues is brilliant! Being enteric, it has no adverse effects on my stomach. I have chronic gastritis, and unlike other omega supplements that caused me pain, this one brings me no discomfort.
Heart Attack
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
USERS' SCORE
Good
Based on 13 Reviews
8.7
9
DHA aids post-heart attack recovery
The polyunsaturated fatty acids, EPA and DHA, ameliorate myocardial infarction-induced heart failure by inhibiting p300-HAT activity in rats.
Most Relevant Research
We explored the effects of docosahexaenoic acid (DHA) on heart attack recovery in rats. The study aimed to understand how DHA, alongside eicosapentaenoic acid (EPA), can influence heart failure following myocardial infarction (MI).
Using several groups of rats experiencing moderate heart issues, we evaluated how these omega-3 fatty acids impacted heart function. We found that both DHA and EPA effectively curtailed the hypertrophic response in heart cells. This response is a significant factor in heart failure, where heart tissue thickens and hardens.
Notably, both DHA and EPA inhibited the activity of a histone acetyltransferase called p300. This activity is linked to molecular changes that promote heart cell enlargement and fibrosis. In our analysis, we observed that these fatty acids not only preserved cardiac function but also prevented structural changes common after a heart attack.
Overall, we noted that DHA had a comparable protective effect to EPA, significantly improving heart health and reducing fibrosis in the heart tissue. As such, the findings suggest that incorporating DHA could be a heart-friendly choice post-heart attack.
Using several groups of rats experiencing moderate heart issues, we evaluated how these omega-3 fatty acids impacted heart function. We found that both DHA and EPA effectively curtailed the hypertrophic response in heart cells. This response is a significant factor in heart failure, where heart tissue thickens and hardens.
Notably, both DHA and EPA inhibited the activity of a histone acetyltransferase called p300. This activity is linked to molecular changes that promote heart cell enlargement and fibrosis. In our analysis, we observed that these fatty acids not only preserved cardiac function but also prevented structural changes common after a heart attack.
Overall, we noted that DHA had a comparable protective effect to EPA, significantly improving heart health and reducing fibrosis in the heart tissue. As such, the findings suggest that incorporating DHA could be a heart-friendly choice post-heart attack.
9.5
Supports heart health
Most Useful Review
I started using this supplement for my heart and vascular system. At 27, I experienced heart tingling which was concerning. Despite taking various vitamins and coenzyme q10, I found my omega-3 levels were low. After starting omega-3, my heart issues resolved. I hope this helps others too!
Heart Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.3
USERS' SCORE
Good
Based on 52 Reviews
8.7
9
Omega-3 lowers coronary risk
A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.
Most Relevant Research
We explored the impact of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on heart disease through a significant study known as the VITAL trial. This study involved nearly 26,000 older adults in the U.S. and aimed to determine the effects of daily EPA supplementation on cardiovascular events over an average follow-up of 5.3 years.
Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.
This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.
This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
8.8
Supports heart health
Most Useful Review
Natural and helpful. It's a great supplement, especially for those with memory issues or high cholesterol. The dosage is significant for older individuals needing preventive care. My relative was prescribed this after a heart attack, and it has greatly supported their recovery.
High Cholesterol
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.8
USERS' SCORE
Good
Based on 8 Reviews
8.7
9
DHA lowers cholesterol; boosts metabolism
F-Fluorodeoxyglucose positron emission tomography/computed tomography imaging reveals the protective effect of docosahexaenoic acid on glucose metabolism by reducing brain 27-hydroxycholesterol.
Most Relevant Research
We aimed to investigate how docosahexaenoic acid (DHA) impacts cholesterol levels and brain glucose metabolism. In our study, we focused on aged SAMP8 mice, dividing them into two groups: a control group and one receiving DHA supplementation.
Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.
These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.
Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.
These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.
8.8
Cholesterol reduction success
Most Useful Review
OMEGA-3 Double Strength has a notable DHA content, perfect for those seeking to lower high cholesterol. Its unique ratio of DHA to EPA, at 2:1, makes it stand out. I noticed improvements in my skin, hair, and dry eyes. My husband, who struggled with high cholesterol, saw positive results after two and a half months of taking Omega-3 alongside lecithin. It's essential to monitor both good and bad cholesterol levels during tests. My cat loves it too, and I believe it benefits her health as well.
Knee Pain
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
USERS' SCORE
Good
Based on 12 Reviews
8.7
9
Fish oil improves knee function
Efficacy and Safety of Fish Oil in Treatment of Knee Osteoarthritis.
Most Relevant Research
We explored how fish oil, rich in docosahexaenoic acid (DHA), can impact knee pain, particularly for those suffering from osteoarthritis. In our study, we involved 75 participants, divided into three groups, each taking either 1,000 mg or 2,000 mg of fish oil daily for eight weeks. We carefully measured their knee pain and walking abilities before and after the supplementation.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
9.5
Improved memory
Most Useful Review
DHA 500 (Omega 3) is excellent for enhancing memory! I purchased it in July 2021 and received it in 10 days without any charges. I take three capsules daily, one before each meal. After two months, I experienced significant improvements in memory and focus for my studies and work, along with relief from my knee pain.
Migraine
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.5
USERS' SCORE
Good
Based on 8 Reviews
8.7
9.5
Eicosapentaenoic acid helps migraines
A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine.
Most Relevant Research
We conducted a thorough investigation into how eicosapentaenoic acid (EPA) can impact episodic migraines. In a carefully designed study, we gathered 70 participants who experienced these migraines and divided them into two groups. One group received a high dose of EPA, while the other was given a placebo. This approach ensured that we could see the true effects of EPA without bias.
After 12 weeks, the results were compelling. We noticed that those taking EPA had significantly fewer migraine days compared to the placebo group. In fact, participants on EPA reported an average reduction of 4.4 days per month, while those on the placebo had barely any change. The EPA group also experienced less need for acute headache medication and marked improvements in headache severity, disability, anxiety, depression, and overall quality of life.
Perhaps most striking was how particularly beneficial EPA seemed to be for female participants. Overall, the study demonstrated that high-dose EPA not only helped reduce the frequency and severity of migraines but also positively influenced the psychological aspects of living with migraines.
This suggests that incorporating EPA into migraine management could be a valuable option for those suffering from episodic migraines, especially as there were no major adverse effects reported.
After 12 weeks, the results were compelling. We noticed that those taking EPA had significantly fewer migraine days compared to the placebo group. In fact, participants on EPA reported an average reduction of 4.4 days per month, while those on the placebo had barely any change. The EPA group also experienced less need for acute headache medication and marked improvements in headache severity, disability, anxiety, depression, and overall quality of life.
Perhaps most striking was how particularly beneficial EPA seemed to be for female participants. Overall, the study demonstrated that high-dose EPA not only helped reduce the frequency and severity of migraines but also positively influenced the psychological aspects of living with migraines.
This suggests that incorporating EPA into migraine management could be a valuable option for those suffering from episodic migraines, especially as there were no major adverse effects reported.
8.8
Helpful migraine relief
Most Useful Review
Best! I love this fish oil! It has undoubtedly rejuvenated my skin, which has become more elastic and smoother. At 56, post-menopause, my skin was fading despite hormonal treatments. This supplement, which I call “fish”, has saved my skin, hair, and nails. My sister’s thin hair has become stronger too. The high docosahexaenoic acid content is great for cardiovascular health and brain function. My migraines have reduced significantly. I highly recommend it, but remember to consult your doctor about the dosage.
Multiple Sclerosis
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.5
USERS' SCORE
Good
Based on 5 Reviews
8.7
8
Eicosapentaenoic acid reduces MS symptoms
Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis.
Most Relevant Research
We explored the therapeutic effects of eicosapentaenoic acid (EPA) in tackling multiple sclerosis through a study involving mice with experimental autoimmune encephalomyelitis (EAE). The mice were given diets enriched with or without EPA. Remarkably, the mice that received the EPA-infused diet displayed significantly lower clinical scores compared to those that did not.
Furthermore, we observed that the production of inflammatory markers like IFN-γ and IL-17 was notably reduced in the EPA-treated mice. This reduction is particularly important, as these markers are associated with the progression of multiple sclerosis. Additionally, there was an enhancement in the expression levels of peroxisome proliferator-activated receptors within the CD4T cells infiltrating the central nervous system.
These findings suggest that EPA could serve as a promising new approach to therapy for multiple sclerosis, showcasing its potential in reducing inflammation and improving clinical outcomes in those affected by this condition.
Furthermore, we observed that the production of inflammatory markers like IFN-γ and IL-17 was notably reduced in the EPA-treated mice. This reduction is particularly important, as these markers are associated with the progression of multiple sclerosis. Additionally, there was an enhancement in the expression levels of peroxisome proliferator-activated receptors within the CD4T cells infiltrating the central nervous system.
These findings suggest that EPA could serve as a promising new approach to therapy for multiple sclerosis, showcasing its potential in reducing inflammation and improving clinical outcomes in those affected by this condition.
8.8
Myelin sheath support
Most Useful Review
Excellent! DHA plays an important role in the omega-3 chain and aids in maintaining the myelin sheath, which is crucial for nerve impulse conduction. As a person with multiple sclerosis, preserving my myelin sheath is vital, and DHA is beneficial. NOW's DHA is cost-effective, offers a generous quantity for the price, and has good quality. The capsule size may be an issue for some, but it doesn't bother me. If you found my comment helpful, please give it a like.
Athlete’s Foot
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Warts disappeared
Most Useful Review
We take omega regularly as a family; this variant has a higher DHA content, which is more beneficial for the brain without causing excitement. Since starting, my child's warts on his feet have disappeared. There’s no fish oil aftertaste, and although the capsules are large, my 7 and 8-year-old children manage fine. I also feel more alert and energetic, with thicker hair and stronger nails. I'd certainly recommend it!
Bruise
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Bruises gone
Most Useful Review
The results in a month are excellent; my daughter’s bruises under her eyes have disappeared, making it easier for her to focus on her studies. Your company is my idol.
Cold Sores
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Reviews
8.6
9.5
Effective against colds
Most Useful Review
We take omega as a family and opt for this company's product for adults. The dosage is convenient with just one capsule a day. Since we started taking omega and D3, we've hardly experienced cold sores and when we do, it's quite mild. One jar lasts us three months, making it a worthwhile investment in terms of price and quality.
Depression
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.1
USERS' SCORE
Good
Based on 7 Reviews
8.6
8
DHA shows potential for depression
The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.
Most Relevant Research
We conducted a study to find out whether docosahexaenoic acid (DHA), a type of omega-3 fatty acid, could effectively help those dealing with major depressive disorder (MDD). Over the course of 12 weeks, 60 participants were involved in a double-blind, placebo-controlled trial. They were divided into two groups: one received 3.2 grams of DHA daily, while the other group was given an equivalent amount of soybean oil as a placebo.
Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.
Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively.
Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.
Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively.
9.5
Improved memory function
Most Useful Review
Breaking old habits can be challenging, especially when it comes to diet. My upbringing led to a lack of Omega-3, which resulted in poor memory and cognitive function. After incorporating DHA into my routine, my memory improved significantly, and I felt more alert. It also positively influenced my skin and hair. I intend to continue supplementing with DHA, especially due to its link to combating depression.
Floaters
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Reduced floaters
Most Useful Review
I've been using this for three months, and I've noticed results regarding my vision. "Floaters", as ophthalmologists call them, have considerably decreased during these months, and my vision is clearer. Omega-3 is essential for retinal health, and I intend to use it for life. The product arrived in just nine days, and I live in rural Goiás.
Hashimoto
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Dietary impact on Hashimoto's inflammation
The Influence of an Anti-Inflammatory Gluten-Free Diet with EPA and DHA on the Involvement of Maresin and Resolvins in Hashimoto's Disease.
Most Relevant Research
We explored how a gluten-free diet (GFD) enriched with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) might influence thyroid inflammation in women with Hashimoto's thyroiditis (HT). This study included 39 Caucasian female patients with autoimmune HT, focusing on the role of long-chain fatty acids as mediators in the inflammatory process.
Notably, we observed that the introduction of a GFD, complemented by omega-3 fatty acids and an increase in vegetable intake, seemed to help reduce inflammation levels in these patients. Specifically, we saw an increase in anti-inflammatory mediators such as resolvins and maresins. This suggests that while eliminating gluten may not be necessary for everyone with HT, the inclusion of EPA and DHA alongside a healthy diet can provoke positive anti-inflammatory changes.
However, it's essential to point out that we found no significant changes in specific thyroid antibody markers, namely anti-TPO and anti-TG levels, meaning that while the dietary approach showed promise, it didn’t necessarily affect every aspect of Hashimoto's disease. Overall, the results highlight the potential of dietary strategies in managing inflammation related to HT.
Notably, we observed that the introduction of a GFD, complemented by omega-3 fatty acids and an increase in vegetable intake, seemed to help reduce inflammation levels in these patients. Specifically, we saw an increase in anti-inflammatory mediators such as resolvins and maresins. This suggests that while eliminating gluten may not be necessary for everyone with HT, the inclusion of EPA and DHA alongside a healthy diet can provoke positive anti-inflammatory changes.
However, it's essential to point out that we found no significant changes in specific thyroid antibody markers, namely anti-TPO and anti-TG levels, meaning that while the dietary approach showed promise, it didn’t necessarily affect every aspect of Hashimoto's disease. Overall, the results highlight the potential of dietary strategies in managing inflammation related to HT.
9.5
Reduced inflammation
Most Useful Review
Now Foods offers great quality at a reasonable price. I appreciate this product as it serves as an excellent source of omega 3, significantly aiding my Hashimoto's. My hair is regrowing and my symptoms are improving, resulting in decreased inflammation. Moreover, there is thankfully no fishy aftertaste when I burp.
Headache
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.2
USERS' SCORE
Good
Based on 10 Reviews
8.6
9.5
Eicosapentaenoic acid reduces migraines
A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine.
Most Relevant Research
We conducted a 12-week study to explore how eicosapentaenoic acid (EPA) affects individuals suffering from episodic migraines. In our trial, 70 participants were randomly split into two groups—one received 2 grams of fish oil with 1.8 grams of pure EPA daily, while the other group got a placebo made of soybean oil.
The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.
Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.
Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.
The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.
Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.
Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.
8.8
Fewer headaches
Most Useful Review
This fish oil is amazing! At 56, my skin has improved immensely and appears more elastic. Despite being on HRT, my skin was fading. This supplement, which I affectionately refer to as "fish," has rejuvenated my skin, hair, and nails. My migraines have lessened, and I recommend it, ensuring to follow the dosage and consult with a doctor.
Hypertension
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.6
9
Eicosapentaenoic acid benefits hypertension
5,6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP signaling pathway.
Most Relevant Research
We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
9.5
Healthy brain development
Most Useful Review
Necessary for pregnant women! From conception to 2 years, consuming DHA is vital for a child’s brain, nervous system, and eye development. The World Health Organization recommends at least 500 mg of DHA daily for pregnant and breastfeeding women. A study from the University of Kansas demonstrated that a daily intake of 600 mg of DHA during pregnancy aids heart development and may protect against hypertension with excess weight.
Hypothyroidism
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Omega-3 benefits in hypothyroidism
The effect of omega-3 on cognition in hypothyroid adult male rats.
Most Relevant Research
We set out to explore how hypothyroidism affects cognitive functions in adult male rats and whether omega-3 supplementation could help. In our study, we divided thirty rats into three groups: a control group, one with induced hypothyroidism, and another that received omega-3 treatment.
The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.
Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.
Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.
The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.
Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.
Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.
8.8
Improved symptoms
Most Useful Review
One of the best omega forms. I consume this regularly, and it has alleviated symptoms associated with my hypothyroidism, such as skin deterioration, concentration loss, sleep issues, irritability, mood swings, chronic fatigue, and worsened allergies. I rely on it due to my AIT and Hashimoto's disease, and my eldest son, aged 16, also takes it as he experiences fatigue from studying remotely.
Insomnia
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5.5
USERS' SCORE
Good
Based on 1 Reviews
8.6
4
Eicosapentaenoic acid shows limited benefits
Omega-3 fatty acids for a better mental state in working populations - Happy Nurse Project: A 52-week randomized controlled trial.
Most Relevant Research
We explored the effectiveness of eicosapentaenoic acid, a type of omega-3 fatty acid, on insomnia among junior hospital nurses in a well-structured trial. In this study, 80 nurses were randomly assigned to receive either 1200 mg of eicosapentaenoic acid along with 600 mg of docosahexaenoic acid daily or a placebo for 13 weeks.
Our main focus was to see how these supplements influenced insomnia and overall mental health. While we noted some improvements in various measures, including insomnia severity at the 13-week mark, the results didn't demonstrate a significant advantage when compared to the placebo group.
After analyzing data at multiple checkpoints—13, 26, and 52 weeks—we found that the effects of eicosapentaenoic acid on insomnia were not strong enough to conclude it as a beneficial treatment. Overall, while there were some positive indicators at certain times, the overall impact on insomnia was not substantial, leaving us to conclude that more research is needed to confirm any real benefits from omega-3 fatty acids for sleep disturbances.
Our main focus was to see how these supplements influenced insomnia and overall mental health. While we noted some improvements in various measures, including insomnia severity at the 13-week mark, the results didn't demonstrate a significant advantage when compared to the placebo group.
After analyzing data at multiple checkpoints—13, 26, and 52 weeks—we found that the effects of eicosapentaenoic acid on insomnia were not strong enough to conclude it as a beneficial treatment. Overall, while there were some positive indicators at certain times, the overall impact on insomnia was not substantial, leaving us to conclude that more research is needed to confirm any real benefits from omega-3 fatty acids for sleep disturbances.
9.5
Eases insomnia
Most Useful Review
Drinking it after dinner helps me fall asleep more easily.
Irritable Bowel Syndrome
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5
USERS' SCORE
Good
Based on 1 Reviews
8.6
5
DHA effects on IBS unclear
Bifidobacterium breve with α-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel syndrome.
Most Relevant Research
We aimed to understand the role of docosahexaenoic acid (DHA) in the context of irritable bowel syndrome (IBS) by investigating how it works alongside Bifidobacterium breve and essential fatty acids, namely α-linolenic acid and linoleic acid.
Our study involved maternally separated and non-separated rats, who received different dietary supplements for a period of seven weeks. We specifically looked for changes in colonic sensitivity and fatty acid profiles in various tissues, comparing supplemented and control groups.
The results showed that feeding B. breve to maternally separated rats notably increased levels of palmitoleic acid, arachidonic acid, and DHA in their liver, along with adjustments in other fatty acids within brain and body fat tissues. However, the same supplementation in non-separated rats elevated other fatty acids, with a significant boost in eicosapentaenoic acid and docosapentaenoic acid in their serum.
Overall, while we observed that DHA levels adjusted in response to the supplementations, the specific effects of DHA on IBS symptoms remain unclear, especially since it was administered in combination with other treatments. This indicates that more focused research on DHA alone is necessary to fully gauge its impact on IBS.
Our study involved maternally separated and non-separated rats, who received different dietary supplements for a period of seven weeks. We specifically looked for changes in colonic sensitivity and fatty acid profiles in various tissues, comparing supplemented and control groups.
The results showed that feeding B. breve to maternally separated rats notably increased levels of palmitoleic acid, arachidonic acid, and DHA in their liver, along with adjustments in other fatty acids within brain and body fat tissues. However, the same supplementation in non-separated rats elevated other fatty acids, with a significant boost in eicosapentaenoic acid and docosapentaenoic acid in their serum.
Overall, while we observed that DHA levels adjusted in response to the supplementations, the specific effects of DHA on IBS symptoms remain unclear, especially since it was administered in combination with other treatments. This indicates that more focused research on DHA alone is necessary to fully gauge its impact on IBS.
9.5
Effective treatment
Most Useful Review
The shipping speed is swift, and after consuming the product, my bowel movements improved significantly; it effectively reduces triglycerides, which is beneficial for managing my irritable bowel syndrome.
Leg Cramps
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.6
9.5
Improved circulation
Most Useful Review
I don’t taste any fishy flavour. Since I began taking two capsules a day as recommended by my nutritionist, I’ve noticed an improvement in my circulation. My leg cramps have lessened significantly.
Menopause
SCIENTIFIC SCORE
Questionable
Based on 27 Researches
6.8
USERS' SCORE
Good
Based on 4 Reviews
8.6
9
DHA alleviates menopausal symptoms
Neurovegetative disorders of perimenopausal women treated with docosahexaenoic acid (DHA, 625 mg).
Most Relevant Research
We explored how docosahexaenoic acid (DHA), at a dosage of 625 mg, affects menopausal symptoms among perimenopausal women. Our study involved 42 participants who were assessed for various symptoms using the Kupperman Index, along with quality of life and sexual function measured through standardized scales.
After six months of DHA treatment, the women reported significant improvements in menopause symptoms, as reflected in their Kupperman Index scores. Specifically, psychological aspects of quality of life showed remarkable enhancement, while physical aspects did not exhibit notable changes.
Additionally, we observed improvements in sexual function, with increases in the Female Sexual Function Index scores and decreases in the Female Sexual Distress Scale, particularly in areas related to arousal and lubrication. Interestingly, the auditory brainstem response also indicated lower wave latencies after treatment, suggesting potential positive effects on neuronal conduction in the auditory system.
Overall, our findings suggest that DHA can effectively help mitigate some perimenopausal symptoms, thereby improving women's quality of life and aspects of sexual health.
After six months of DHA treatment, the women reported significant improvements in menopause symptoms, as reflected in their Kupperman Index scores. Specifically, psychological aspects of quality of life showed remarkable enhancement, while physical aspects did not exhibit notable changes.
Additionally, we observed improvements in sexual function, with increases in the Female Sexual Function Index scores and decreases in the Female Sexual Distress Scale, particularly in areas related to arousal and lubrication. Interestingly, the auditory brainstem response also indicated lower wave latencies after treatment, suggesting potential positive effects on neuronal conduction in the auditory system.
Overall, our findings suggest that DHA can effectively help mitigate some perimenopausal symptoms, thereby improving women's quality of life and aspects of sexual health.
8.8
Skin rejuvenation
Most Useful Review
Best! I adore this fish oil! It has undeniably rejuvenated my skin, making it more elastic and smoother. Despite being 56 and on HRT since menopause began at 48, my skin was fading. This "fish" is a lifesaver for my skin, hair, and nails. My sister's thin hair also became stronger. The high docosahexaenoic acid content is beneficial for cardiovascular health and has reduced my migraines. I highly recommend it but remember to follow the dosage and consult your doctor first.
Stroke
SCIENTIFIC SCORE
Moderately Effective
Based on 19 Researches
8.1
USERS' SCORE
Good
Based on 7 Reviews
8.6
9
DHA shows stroke protection potential
Docosahexaenoic acid protects against ischemic stroke in diabetic mice by inhibiting inflammatory responses and apoptosis.
Most Relevant Research
We aimed to find out whether docosahexaenoic acid (DHA) could offer protection against ischemic stroke in diabetic mice and better understand how it works. In our study, we administered DHA to diabetic mice after they experienced an ischemic stroke and evaluated their recovery over 24 hours and again at three days.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
The results were promising; DHA treatment significantly reduced the overall size of brain damage, minimized swelling, and improved neurological function. We observed a notable drop in harmful inflammatory responses. For instance, the number of neutrophils, a type of immune cell that can exacerbate inflammation, decreased in the brain tissue.
Additionally, we noticed that DHA seemed to help the balance between proteins related to cell death. Specifically, it lowered levels of Bax, a pro-apoptotic protein, and increased levels of Bcl-2, which protects cells from death. Our analysis of brain tissue genes indicated that DHA helped regulate inflammatory pathways while boosting beneficial neuroprotective pathways.
The changes weren't limited to the brain either; similar positive shifts occurred in the blood cells, showcasing a systemic benefit. Overall, DHA appears to reduce the damage from stroke by lessening inflammation and cell death in diabetic mice, highlighting its potential as a treatment option for strokes in diabetic individuals.
9.5
Stimulates recovery
Most Useful Review
This is a great supplement for the brain, particularly beneficial for schoolchildren and those recovering from a stroke, as it aids memory and concentration.
Arteriosclerosis
SCIENTIFIC SCORE
Questionable
Based on 28 Researches
6.9
USERS' SCORE
Good
Based on 1 Reviews
8.5
9
DHA stabilizes arterial plaques
Injectable liposomal docosahexaenoic acid alleviates atherosclerosis progression and enhances plaque stability.
Most Relevant Research
We embarked on a quest to understand how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, can impact atherosclerosis, a condition where fatty deposits clog the arteries. Our focus was on a specially developed injectable formulation that delivers DHA directly to the site of arterial plaques.
Through our research, we discovered that this liposomal DHA formulation not only protects the compound but also enhances its effectiveness. When we administered it intravenously, DHA particles were specifically absorbed by macrophages—immune cells involved in the inflammation seen in atherosclerosis. This targeted delivery helps reduce inflammation and prevents the formation of foam cells, which are a hallmark of atherosclerotic plaques.
Furthermore, our analysis of the plaques revealed that the DHA treatment led to less macrophage infiltration and reduced lipid build-up, which improves overall plaque stability. In simpler terms, we observed that the treatment makes plaques less likely to rupture, which is critical in preventing serious cardiovascular problems. Additionally, sophisticated imaging techniques showed that DHA can help restore some of the healthy lipid profiles typical of earlier stages of plaque development.
In summary, using injectable DHA offers exciting potential for stabilizing arterial plaques and slowing down the progression of atherosclerosis. Given the importance of addressing this condition, our findings could pave the way for new therapeutic strategies to reduce the risk of heart-related issues.
Through our research, we discovered that this liposomal DHA formulation not only protects the compound but also enhances its effectiveness. When we administered it intravenously, DHA particles were specifically absorbed by macrophages—immune cells involved in the inflammation seen in atherosclerosis. This targeted delivery helps reduce inflammation and prevents the formation of foam cells, which are a hallmark of atherosclerotic plaques.
Furthermore, our analysis of the plaques revealed that the DHA treatment led to less macrophage infiltration and reduced lipid build-up, which improves overall plaque stability. In simpler terms, we observed that the treatment makes plaques less likely to rupture, which is critical in preventing serious cardiovascular problems. Additionally, sophisticated imaging techniques showed that DHA can help restore some of the healthy lipid profiles typical of earlier stages of plaque development.
In summary, using injectable DHA offers exciting potential for stabilizing arterial plaques and slowing down the progression of atherosclerosis. Given the importance of addressing this condition, our findings could pave the way for new therapeutic strategies to reduce the risk of heart-related issues.
8.8
Supports arterial health
Most Useful Review
I find this product very good and of high quality, imported from the USA. I ordered it for my parents to help combat arteriosclerosis and prevent clogged arteries. The ingredients are excellent, making this the best choice. I plan to recommend it to friends and family. It’s derived from deep-sea fish and suitable for those aged 26 and above. The packaging is quite large.
Dizziness
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Reviews
8.5
8
Dizziness relief
Most Useful Review
I have been taking these capsules for six months to address issues with the vessels in my head, particularly dizziness. I prefer them as they do not cause fish burping, unlike another omega my husband consumes. Initially, I took 1-2 capsules daily, but my doctor has advised three due to my cholesterol levels nearing the upper limit. I also include vitamin D and additional cytokolins in my routine. I will retake my analysis in a month.
Psoriasis
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.4
USERS' SCORE
Good
Based on 1 Reviews
8.5
8
EPA benefits psoriatic skin health
Eicosapentaenoic Acid Influences the Lipid Profile of an In Vitro Psoriatic Skin Model Produced with T Cells.
Most Relevant Research
We aimed to understand how eicosapentaenoic acid (EPA) affects psoriasis, a skin condition known for causing redness, irritation, and thickened skin. By creating skin models that reflect both healthy and psoriatic conditions, we were able to assess the impact of EPA directly on lipid profiles—a key factor in skin health.
Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.
More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.
Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.
More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.
8.8
Reduces itchiness
Most Useful Review
It is not the first bottle I have purchased; it is a staple in my routine. This product works well for my skin issues, especially as I suffer from psoriasis, which it alleviates by reducing itchiness. It is also essential for anyone with dry skin.
Bone Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 17 Reviews
8.4
9.5
Best value for DHA
Most Useful Review
I use high DHA together with Turmeric, Boswellia, and Tart Cherry for my joint pain at night. The Now Foods DHA-500 offers excellent value and works wonderfully without any fishy aftertaste.
Cancer
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
DHA affects colorectal cancer pathways
Dietary polyunsaturated fatty acids affect PPARγ promoter methylation status and regulate the PPARγ/COX2 pathway in some colorectal cancer cell lines.
Most Relevant Research
We set out to explore how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects colorectal cancer (CRC) cells. In this study, we treated five different colorectal cancer cell lines with varying concentrations of DHA, along with other fatty acids like eicosapentaenoic acid (EPA) and linoleic acid (LA). This allowed us to see if DHA could impact the methylation patterns of the PPARγ promoter, a key player in cancer regulation, and affect the relationship between PPARγ and COX2, two important molecules involved in cancer growth.
Our findings revealed that DHA significantly altered the methylation status in some cell lines, effectively demethylating specific regions of the PPARγ promoter. We observed that this demethylation was linked to an increase in the expression of PPARγ in cells where it was hemimethylated. Interestingly, DHA not only boosted PPARγ levels but also downregulated COX2 across all CRC cell lines tested. This suggests that DHA might have a role in reducing inflammatory signals linked to cancer progression.
The overall impact seemed to vary depending on the type of cancer cell we were working with, indicating a cell type-dependent effect of DHA. Notably, we found that DHA was more effective than EPA or LA in modulating the PPARγ promoter. This research shows promising potential for DHA in colorectal cancer treatment and highlights its importance in dietary considerations for cancer management.
Our findings revealed that DHA significantly altered the methylation status in some cell lines, effectively demethylating specific regions of the PPARγ promoter. We observed that this demethylation was linked to an increase in the expression of PPARγ in cells where it was hemimethylated. Interestingly, DHA not only boosted PPARγ levels but also downregulated COX2 across all CRC cell lines tested. This suggests that DHA might have a role in reducing inflammatory signals linked to cancer progression.
The overall impact seemed to vary depending on the type of cancer cell we were working with, indicating a cell type-dependent effect of DHA. Notably, we found that DHA was more effective than EPA or LA in modulating the PPARγ promoter. This research shows promising potential for DHA in colorectal cancer treatment and highlights its importance in dietary considerations for cancer management.
8
Support for cancer
Most Useful Review
I took this to my mother, a cancer patient. I've read much praise for it concerning those on the keto diet. The packaging is large, and the fish monk is easy for her to swallow, suiting her dietary needs. The ingredients are excellent for a cancer patient, and my mother began today. The quality of this product is also highly esteemed. My mother is 72; I pray for her healing.
Chest Pain
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.5
USERS' SCORE
Good
Based on 6 Reviews
8.4
7
Eicosapentaenoic acid showed mixed results
Improvement of coronary vasomotion with eicosapentaenoic acid does not inhibit acetylcholine-induced coronary vasospasm in patients with variant angina.
Most Relevant Research
We examined how eicosapentaenoic acid (EPA), a key ingredient found in fish oil, impacts chest pain in patients with variant angina. Our study followed 22 individuals with this condition, where we infused acetylcholine, a substance known to cause coronary vasospasm, both before and after a four-month course of EPA treatment (1.8 g/day for 12 patients).
In the group that did not receive EPA, we observed no changes in how their coronary arteries responded to acetylcholine over time. However, for those treated with EPA, the results were quite intriguing. In non-spastic areas, the response shifted from vasoconstriction (narrowing) to vasodilation (widening). This indicates a notable improvement in how these arteries are functioning.
Yet, when it came to spastic sites where vasospasm had occurred, the coronary arteries remained responsive to acetylcholine, and the vasospasm persisted despite the EPA treatment. Thus, while EPA enhanced coronary responsiveness in some areas, it did not eliminate the acetylcholine-induced coronary vasospasms associated with variant angina.
In the group that did not receive EPA, we observed no changes in how their coronary arteries responded to acetylcholine over time. However, for those treated with EPA, the results were quite intriguing. In non-spastic areas, the response shifted from vasoconstriction (narrowing) to vasodilation (widening). This indicates a notable improvement in how these arteries are functioning.
Yet, when it came to spastic sites where vasospasm had occurred, the coronary arteries remained responsive to acetylcholine, and the vasospasm persisted despite the EPA treatment. Thus, while EPA enhanced coronary responsiveness in some areas, it did not eliminate the acetylcholine-induced coronary vasospasms associated with variant angina.
9.5
Joint pain relief
Most Useful Review
This product was recommended by my doctor, and after a few weeks, my joint and back pain vanished. It's beneficial for the brain, heart, and eyes as well. I believe its anti-inflammatory properties surpass any pharmaceutical alternatives. I wholeheartedly recommend it for anyone suffering from chest pain.
Liver Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8.4
9
DHA-PS promotes liver recovery
DHA-enriched phosphatidylserine ameliorates cyclophosphamide-induced liver injury via regulating the gut-liver axis.
Most Relevant Research
We investigated the potential of DHA-enriched phosphatidylserine (DHA-PS) in addressing liver injuries caused by cyclophosphamide in mice. By administering cyclophosphamide over five days, we created a model to simulate this liver damage. Following this, we treated the mice with different doses of DHA-PS for a week to see if it could help heal their livers.
Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.
Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.
Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.
Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.
Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.
Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.
8.8
Improves liver health
Most Useful Review
DHA food supplement with excellent quality. It contains Omega 3 fish oil, DHA (500 mg per capsule), and EPA (250 mg). The capsules are medium-sized, odourless, and sealed. I have noticed improvements in my health, including reduced risk of liver disease, coronary heart disease, stroke, and enhanced brain activity. I take one capsule once or twice daily with meals, and it has also improved my hair structure.
Osteoporosis
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.4
9
DHA's role in osteoporosis treatment
Comparative study of DHA-enriched phosphatidylcholine and EPA-enriched phosphatidylcholine on ameliorating high bone turnover regulation of the osteogenesis-related Wnt/β-catenin pathway in ovariectomized mice.
Most Relevant Research
We recently looked into how docosahexaenoic acid (DHA), through its enriched phosphatidylcholine form (DHA-PC), affects osteoporosis. Using a model that simulates the condition in women after ovariectomy, we compared the impact of DHA-PC with eicosapentaenoic acid (EPA) enriched phosphatidylcholine (EPA-PC). Our findings revealed that both DHA-PC and EPA-PC significantly improved the structural quality of trabecular bone, boosted the rate of new bone formation, and elevated bone mineral density, which are crucial factors in combating osteoporosis.
We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.
Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.
We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.
Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.
7.5
Reduced inflammation benefits
Most Useful Review
Omega-3s support joint health and osteoporosis prevention. They combat inflammation, mitigate bone loss, and relieve joint pain. Moreover, they help lessen rheumatoid arthritis symptoms and slow the degeneration of articular cartilage in cases of arthrosis.
Frozen Shoulder
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.3
9.5
Aches alleviated
Most Useful Review
Since taking this supplement, my frozen shoulder aches have gone. I started on 1st January 2021, and after a couple of weeks, I discovered I could sleep through the night without pain. The product has no aftertaste and offers a high level of omega-3 at an economical price. I would recommend it to anyone seeking a good omega supplement.
Pelvic Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Reviews
8.3
6.3
Reduced pelvic pain
Most Useful Review
It is a repeat. I believe my pelvic pain has reduced, though this may not be solely due to this treatment as I am drinking others too.
Arthritis
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.3
USERS' SCORE
Good
Based on 8 Reviews
8.2
8
Eicosapentaenoic acid aids arthritis
Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Most Relevant Research
We explored the effects of eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, on patients with rheumatoid arthritis (RA). This analysis gathered data from eighteen randomized controlled trials involving over a thousand RA patients, ensuring a comprehensive look at its impact.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
9.5
Arthritis improvement
Most Useful Review
I highly recommend this Omega 3 package. It’s excellent for arthritis and heart health, with great taste and quality. It lowers cholesterol, improves lifespan, and has beneficial ingredients.
Blood Clot
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.6
USERS' SCORE
Good
Based on 6 Reviews
8.2
9
Eicosapentaenoic acid influences clotting
Emergence of omega-3 fatty acids in biomedical research.
Most Relevant Research
We explored how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences blood clotting processes. The interest in EPA grew substantially after the 1970s when researchers Dyerberg and Bang noted that Greenland Eskimos had lower rates of coronary disease linked to their diet rich in marine lipids.
Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.
Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.
Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.
Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.
9.5
Improves inflammation
Most Useful Review
This is my second time taking Now Foods DHA-500, and I'm pleased with its quality. The large capsules are easy to swallow. My son's facial inflammation has disappeared, and one capsule daily suffices for our family’s omega-3 needs. It’s essential for our heart, blood vessels, and brain health.
Diarrhea
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Good
Based on 1 Reviews
8.2
8
5,6-DiHETE alleviates diarrhea
Efficient Attenuation of Dextran Sulfate Sodium-Induced Colitis by Oral Administration of 5,6-Dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic Acid in Mice.
Most Relevant Research
We examined how eicosapentaenoic acid, specifically a compound called 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid (5,6-DiHETE), affects diarrhea caused by inflammation in mice. In our study, the mice were given a substance that induces colitis, known as dextran sulfate sodium (DSS), and then treated with different doses of 5,6-DiHETE orally.
What we found was promising: the administration of both 150 and 600 micrograms of 5,6-DiHETE daily helped to speed up the recovery from diarrhea. After just a few days of treatment, we observed significant improvements in the mice’s condition. The daily doses led to less inflammation in the colon and a notable reduction in the symptoms of diarrhea associated with DSS-induced colitis.
We also measured how much of this compound remained in the mice's blood after taking it, finding that it peaked within half an hour of administration. This suggests that 5,6-DiHETE works relatively quickly to start affecting the inflammation. Overall, our research indicates that eicosapentaenoic acid holds potential as a beneficial treatment for inflammatory bowel diseases that cause diarrhea.
What we found was promising: the administration of both 150 and 600 micrograms of 5,6-DiHETE daily helped to speed up the recovery from diarrhea. After just a few days of treatment, we observed significant improvements in the mice’s condition. The daily doses led to less inflammation in the colon and a notable reduction in the symptoms of diarrhea associated with DSS-induced colitis.
We also measured how much of this compound remained in the mice's blood after taking it, finding that it peaked within half an hour of administration. This suggests that 5,6-DiHETE works relatively quickly to start affecting the inflammation. Overall, our research indicates that eicosapentaenoic acid holds potential as a beneficial treatment for inflammatory bowel diseases that cause diarrhea.
5
Initial diarrhoea experience
Most Useful Review
If you're seeking high-quality omega 3s, this option is good. Each capsule contains 750mg of omega 3 (500 DHA + 250 EPA), so I take at least 2 capsules daily, as the minimum recommended dose is 1200mg/day for benefits. Initially, I experienced diarrhoea, but I've adjusted now. I advise consulting a doctor regarding blood thinners and stopping omega 3 at least 2 weeks before any surgery. The product is distilled and comes well packaged, although it has less taste and smell.
Nausea
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Researches
7
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.6
7
Dysmenorrhea influences pregnancy nausea
Association of the Verbal Rating Scale-Measured Dysmenorrhea with Nausea and Vomiting in Pregnancy: A Retrospective Cohort Study.
Most Relevant Research
We conducted a retrospective cohort study to investigate the relationship between nausea and vomiting in pregnancy (NVP) and dysmenorrhea measured by a verbal rating scale. Our research included 443 pregnant women, divided into those experiencing NVP and a control group.
From our findings, we noticed a clear association between moderate to severe dysmenorrhea and a heightened risk of NVP, especially during the first trimester. This suggests that those with painful menstrual symptoms may face an increased likelihood of nausea and vomiting as part of their pregnancy experience.
Importantly, we also examined the impact of periconceptional supplementation with docosahexaenoic acid (DHA). Our results indicated that taking DHA could potentially lower the risk of NVP, offering a glimmer of hope for managing nausea during pregnancy. This suggests that combining DHA with standard prenatal care might be beneficial for those who struggle with these symptoms.
Overall, our study sheds light on the intricate connections between menstrual pain and pregnancy-related nausea, emphasizing the potential protective role of DHA in improving women's health during this time.
From our findings, we noticed a clear association between moderate to severe dysmenorrhea and a heightened risk of NVP, especially during the first trimester. This suggests that those with painful menstrual symptoms may face an increased likelihood of nausea and vomiting as part of their pregnancy experience.
Importantly, we also examined the impact of periconceptional supplementation with docosahexaenoic acid (DHA). Our results indicated that taking DHA could potentially lower the risk of NVP, offering a glimmer of hope for managing nausea during pregnancy. This suggests that combining DHA with standard prenatal care might be beneficial for those who struggle with these symptoms.
Overall, our study sheds light on the intricate connections between menstrual pain and pregnancy-related nausea, emphasizing the potential protective role of DHA in improving women's health during this time.
9.5
No nausea noted
Most Useful Review
We take this fish oil as a family. I give my 8-year-old 1 capsule and adults 2 capsules daily. We tolerate this fish oil well without side effects such as nausea, dizziness, or a bad aftertaste. There are no fish burps either. Although the capsules are slightly larger than average, they are easy to swallow. I've noticed an improvement in my skin and hair.
Heartburn
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.5
9.5
No heartburn
Most Useful Review
Good Omega Cool enteric omega for those with heartburn. I enjoy taking it regularly without experiencing heartburn or an unpleasant taste. The dosage is excellent; I take two capsules after breakfast.
