' 
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 180 mg Ferrous Bisglycinate)(Ferrochel™)
36 mg
200%
The product is found useful for the following medical conditions
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Excellent
Based on 118 Reviews
9.1
7
Iron boosts fatigue symptoms
The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT.
Most Relevant Research
We explored the effects of iron supplementation on individuals suffering from iron deficiency, specifically looking at its impact on symptoms like chronic fatigue syndrome (CFS). This was done through a well-structured study involving 176 blood donors who were iron deficient, with a randomized controlled trial design.
Participants were assigned to receive either intravenous iron or oral iron supplements. Over an 8-12 week period, we assessed changes in symptoms related to iron deficiency, including CFS, restless legs syndrome (RLS), sleeping disorders, and overall quality of life.
The results indicated that iron supplementation may significantly improve the symptoms associated with iron deficiency among blood donors. By addressing the iron deficiency, we noted improvements not only in fatigue but also in wellbeing, confirming that targeted iron treatment can be beneficial for those struggling with chronic fatigue linked to low iron levels. This is an exciting finding for both clinicians and patients, shedding light on a relatively simple intervention that can enhance quality of life.
Participants were assigned to receive either intravenous iron or oral iron supplements. Over an 8-12 week period, we assessed changes in symptoms related to iron deficiency, including CFS, restless legs syndrome (RLS), sleeping disorders, and overall quality of life.
The results indicated that iron supplementation may significantly improve the symptoms associated with iron deficiency among blood donors. By addressing the iron deficiency, we noted improvements not only in fatigue but also in wellbeing, confirming that targeted iron treatment can be beneficial for those struggling with chronic fatigue linked to low iron levels. This is an exciting finding for both clinicians and patients, shedding light on a relatively simple intervention that can enhance quality of life.
9.5
Increased iron levels
Most Useful Review
Effective iron! It raised my ferritin levels. I felt overwhelmed and fatigued, with my ferritin at 18.3 in January. After much research, I opted for this iron bisglycinate, which has a good dosage and quality. I took it twice daily with vitamin C, and my energy improved significantly.
Allergies
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Excellent
Based on 13 Reviews
9
8
Allergy management in iron treatments
From diagnosis to desensitization in immediate hypersensitivity reactions to both oral and parenteral iron salts.
Most Relevant Research
We examined the rise of hypersensitivity reactions (HRs) linked to iron agents, especially as their usage in treating iron deficiency has increased. In this study, we evaluated the clinical features of patients who experienced immediate hypersensitivity reactions (IHRs) to both oral and intravenous (IV) iron preparations.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
9.5
No allergies noted
Most Useful Review
Excellent hardware. It raised my sister's hemoglobin; it didn't work the first time. No allergies were identified.
Autoimmune Disorder
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Excellent
Based on 95 Reviews
9
8
Ferroportin regulates RA cell activity
Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway.
Most Relevant Research
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
9.5
Raised hemoglobin levels
Most Useful Review
This is the best iron for treating my autoimmune disorder during pregnancy. Despite various prescriptions failing to help, I turned to this product. Within three weeks, my haemoglobin rose from 96 to 123, and ferritin increased from 40 to nearly 90. I also experienced no gastrointestinal issues, unlike previous products. I'm glad to share my experience; it really works!
Back Pain
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 18 Reviews
8.9
9
HP alleviates iron-induced back pain
Inhibits Iron Overload-Induced Oxidative Stress through Activation of Signaling in a Rat Model of Lumbar Spinal Stenosis.
Most Relevant Research
We investigated how a substance called HP influences iron-related oxidative stress and its connection to back pain in a common condition known as lumbar spinal stenosis (LSS). LSS causes significant discomfort and disability, particularly for older adults, primarily due to hypertrophy of the ligamentum flavum, which can be exacerbated by oxidative stress stemming from imbalanced iron levels.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
9.5
Dizziness reduction
Most Useful Review
I previously took a Japanese heme iron supplement but experienced dizziness, nausea, and migraines. After switching to a high-quality iron supplement, I noticed an improvement in my dizziness by the second day and my migraines vanished within a week. Though the capsules have an iron smell, I highly recommend this for anyone who has not found relief with Japanese heme iron.
Heart Attack
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 8 Reviews
8.9
9
Macrophage EVs combat iron overload
Macrophage-derived extracellular vesicles represent a promising endogenous iron-chelating therapy for iron overload and cardiac injury in myocardial infarction.
Most Relevant Research
We delved into the connection between iron overload and its effects on heart function after a heart attack, also known as myocardial infarction (MI). Our research focused on utilizing macrophage-derived extracellular vesicles (EVs) as a natural therapy to help with excessive iron levels in the heart.
The downside of existing chemical iron chelators is that they often come with side effects, so we sought a safer and more effective solution. By isolating EVs from macrophages, we found that they serve as a biological chelator for iron. When we introduced these EVs to heart cells affected by low oxygen levels, they significantly reduced iron overload and minimized the oxidative stress linked to this excess iron.
Notably, these EVs work by harnessing a receptor called transferrin receptor (TfR), which helps them grab onto and remove the surplus protein-bound iron. In our observations, when the EVs lacked TfR, they were ineffective in protecting heart tissue. This shows that leveraging macrophage-derived EVs could offer a new approach in treating heart damage due to iron overload, especially after myocardial infarction.
The downside of existing chemical iron chelators is that they often come with side effects, so we sought a safer and more effective solution. By isolating EVs from macrophages, we found that they serve as a biological chelator for iron. When we introduced these EVs to heart cells affected by low oxygen levels, they significantly reduced iron overload and minimized the oxidative stress linked to this excess iron.
Notably, these EVs work by harnessing a receptor called transferrin receptor (TfR), which helps them grab onto and remove the surplus protein-bound iron. In our observations, when the EVs lacked TfR, they were ineffective in protecting heart tissue. This shows that leveraging macrophage-derived EVs could offer a new approach in treating heart damage due to iron overload, especially after myocardial infarction.
9.5
Improved hemoglobin levels
Most Useful Review
The rescue! Three years ago, I struggled with treating my anaemia; my haemoglobin was stuck at 80. After taking this specific iron supplement for two years, my haemoglobin is now consistently 140. I no longer experience the headaches I used to, nor am I freezing like before. This product is irreplaceable for me.
Knee Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 8 Reviews
8.9
8
Iron treatment aids knee recovery
Blood management of staged bilateral total knee arthroplasty in a single hospitalization period.
Most Relevant Research
We focused on the effects of iron treatment as part of a broader strategy for managing blood loss and pain in patients undergoing staged bilateral total knee arthroplasty (TKA) within a single hospital stay. In our study, we compared two groups of patients: one receiving a newly introduced multimodal blood management (MBM) approach that included preoperative oral iron treatment, and a control group that only received standard care.
Our findings were promising. The group treated with the MBM protocol experienced significantly lower rates of blood transfusion—only 9% of patients required one—compared to 32.4% in the control group. This approach not only reduced the need for additional blood transfusions but also led to improvements in postoperative hemoglobin levels and reduced pain and swelling in the knees after surgery.
The results suggest that incorporating iron treatment in a comprehensive management program can effectively help alleviate knee pain and enhance recovery from surgery. Best of all, this was achieved without leading to any significant complications, indicating a safe and economical option for improving outcomes in TKA patients.
Our findings were promising. The group treated with the MBM protocol experienced significantly lower rates of blood transfusion—only 9% of patients required one—compared to 32.4% in the control group. This approach not only reduced the need for additional blood transfusions but also led to improvements in postoperative hemoglobin levels and reduced pain and swelling in the knees after surgery.
The results suggest that incorporating iron treatment in a comprehensive management program can effectively help alleviate knee pain and enhance recovery from surgery. Best of all, this was achieved without leading to any significant complications, indicating a safe and economical option for improving outcomes in TKA patients.
9.5
Improved mobility
Most Useful Review
Excellent. I have suffered from terrible knee pain due to iron deficiency. Thankfully, I no longer feel light-headed or weak in my knees, and I can now walk and take the stairs without fatigue. I strongly recommend this treatment for anyone facing iron deficiency.
Pelvic Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 26 Reviews
8.9
9.5
Reduced pelvic pain
Most Useful Review
On discovering Dr. Fujikawa's book, I started taking iron for severe menstrual pain and PMS. Over three years, it has greatly eased my lower back pain and reduced dizziness when standing and morning fatigue. I worry about running out of this supplement!
Anemia
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
USERS' SCORE
Good
Based on 292 Reviews
8.8
9.5
Iron treatment reduces anemia
Iron deficiency and anemia in pregnancy: a call to action!: -"If you don't take a temperature, you can't find a fever".
Most Relevant Research
We examined how iron treatment specifically impacts anemia, particularly during pregnancy. Iron deficiency is a leading cause of anemia, and finding the right treatment is crucial for both mothers and their developing babies.
Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.
However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.
However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
9.5
Improved hemoglobin
Most Useful Review
I found this iron supplement incredibly effective during my pregnancy when I suffered from anemia. None of the prescribed medications improved my condition. After researching, I discovered that diglycinate is well absorbed. Within three weeks of taking this supplement, my hemoglobin rose from 96 to 123, and my ferritin levels improved from 40 to nearly 90. Unlike earlier medications, I experienced no gastrointestinal issues. I hope my review helps you!
Chest Pain
SCIENTIFIC SCORE
Likely Very Effective
Based on 3 Researches
9.2
USERS' SCORE
Good
Based on 4 Reviews
8.8
9
Endometrial cancer-induced angina case
An atypical presentation of endometrial cancer as angina secondary to critically low hemoglobin and iron deficiency associated pancytopenia: A case report.
Most Relevant Research
We explored the intriguing link between iron treatment and angina symptoms in a unique case involving a 46-year-old woman with endometrial cancer. This patient arrived in the emergency department with acute chest pain, yet her heart was healthy based on ECG results. Instead, we found that her chest pain was a result of critically low hemoglobin levels caused by severe iron deficiency anemia.
Over the past six months, the patient experienced prolonged and heavy menstruation, which contributed to her anemia. After administering six units of packed red blood cells and an iron infusion, we witnessed a remarkable turnaround. The chest pain resolved, and her blood counts improved significantly.
This case is particularly noteworthy for highlighting how essential it is for women experiencing chest pain to be evaluated for anemia. It serves as a crucial reminder that understanding a patient's gynecological history can shed light on their overall health and symptoms. The link between iron treatment and relief from chest pain underscores the importance of recognizing the systemic effects of anemia.
Over the past six months, the patient experienced prolonged and heavy menstruation, which contributed to her anemia. After administering six units of packed red blood cells and an iron infusion, we witnessed a remarkable turnaround. The chest pain resolved, and her blood counts improved significantly.
This case is particularly noteworthy for highlighting how essential it is for women experiencing chest pain to be evaluated for anemia. It serves as a crucial reminder that understanding a patient's gynecological history can shed light on their overall health and symptoms. The link between iron treatment and relief from chest pain underscores the importance of recognizing the systemic effects of anemia.
9.5
Improved well-being
Most Useful Review
I was shocked by the results of taking this iron! My hemoglobin was consistently low due to inadequate iron in my diet. After starting this chelative iron, I noticed improved health and a significant rise in my hemoglobin from 113 to 144. I experienced no side effects, such as chest pain, constipation, or nausea. I highly recommend this iron supplement for anyone in a similar situation.
Dizziness
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.8
USERS' SCORE
Good
Based on 163 Reviews
8.8
9
Effect of iron on dizziness relief
Critical iron deficiency anemia with record low hemoglobin: a case report.
Most Relevant Research
We studied the impact of iron treatment on dizziness experienced by a 42-year-old woman suffering from severe iron deficiency anemia due to menometrorrhagia. Throughout her hospital stay, she received blood transfusions and intravenous iron, which played a critical role in addressing her debilitating symptoms.
Remarkably, despite her initial critically low hemoglobin levels, she managed to remain hemodynamically stable. By the end of her treatment, her symptoms of fatigue and dizziness had resolved, allowing her to return to her normal activities before discharge. This case highlights an important connection between iron levels and dizziness, illustrating that replenishing iron can significantly alleviate dizzy spells linked to anemia.
Our findings underscore how crucial it is to address iron deficiency effectively, as it can prevent serious complications and improve overall quality of life for patients experiencing symptoms like dizziness.
Remarkably, despite her initial critically low hemoglobin levels, she managed to remain hemodynamically stable. By the end of her treatment, her symptoms of fatigue and dizziness had resolved, allowing her to return to her normal activities before discharge. This case highlights an important connection between iron levels and dizziness, illustrating that replenishing iron can significantly alleviate dizzy spells linked to anemia.
Our findings underscore how crucial it is to address iron deficiency effectively, as it can prevent serious complications and improve overall quality of life for patients experiencing symptoms like dizziness.
9
Dizziness eliminated
Most Useful Review
I experienced very painful periods, constant fatigue, dizziness, and loss of consciousness. My ferritin was significantly low, so I ordered chelated iron. I initially planned to keep it for myself, but my friend, who was pregnant and needed it more, ended up taking it. I felt a marked improvement with no more dizziness or fatigue and my energy levels increased. I plan to repeat the ferritin test soon; compared to previous medications, this has been a fantastic result.
Food Poisoning
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 2 Reviews
8.8
8
Iron treatment's effects on campylobacteriosis
Iron Deprivation by Oral Deferoxamine Application Alleviates Acute Campylobacteriosis in a Clinical Murine Infection Model.
Most Relevant Research
We explored how iron influences food poisoning, particularly in the context of campylobacteriosis, a common foodborne illness. Our focus was on the effects of deferoxamine (DESF), an iron-chelating compound, when administered orally to mice before they were infected.
In our study, we included microbiota-depleted IL-10 mice that received DESF through their drinking water starting a week ahead of being exposed to the Campylobacter strain known as 81-176. While we did not observe any significant reduction in the levels of the bacteria in the gastrointestinal tract, we did identify some noteworthy improvements in the overall health status of the infected mice by the sixth day post-infection.
These findings suggested that DESF treatment seemed to alleviate the disease's impact, manifesting as reduced cell death in the colon, lower numbers of immune cells like neutrophils accumulating in the large intestines, and decreased levels of inflammatory markers, including IFN-γ and MCP-1, in both the intestines and systemically.
Overall, our research illustrates the potential for iron-targeting strategies to positively affect the progression and severity of campylobacteriosis, offering a new outlook for treatment approaches when conventional antibiotic methods are not recommended.
In our study, we included microbiota-depleted IL-10 mice that received DESF through their drinking water starting a week ahead of being exposed to the Campylobacter strain known as 81-176. While we did not observe any significant reduction in the levels of the bacteria in the gastrointestinal tract, we did identify some noteworthy improvements in the overall health status of the infected mice by the sixth day post-infection.
These findings suggested that DESF treatment seemed to alleviate the disease's impact, manifesting as reduced cell death in the colon, lower numbers of immune cells like neutrophils accumulating in the large intestines, and decreased levels of inflammatory markers, including IFN-γ and MCP-1, in both the intestines and systemically.
Overall, our research illustrates the potential for iron-targeting strategies to positively affect the progression and severity of campylobacteriosis, offering a new outlook for treatment approaches when conventional antibiotic methods are not recommended.
10
Improved condition
Most Useful Review
This is a very cool find! After starting on supplemental iron, my ferritin levels rose from 40 to 70, significantly alleviating my lethargy and constant fatigue. My hair loss has also reduced. I took one capsule daily with food for two months, and I definitely recommend it! Let me know if you find my review helpful.
Hypothyroidism
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 10 Reviews
8.8
9.5
Improved energy
Most Useful Review
Super supplement! I've suffered from iron deficiency and hypothyroidism for years. Nothing helped until I tried this chelated iron. It greatly improved my condition, eliminating dizziness and fatigue. I take it regularly and will continue to monitor my ferritin levels. Overall, it’s a fantastic product for managing my iron levels.
Cardiovascular Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 2 Reviews
8.7
7
Iron deficiency impacts heart failure
Impact of iron deficiency on congestion and postdischarge survival in patients recently hospitalised for decompensated heart failure: a multicentre, prospective, observational analysis of the FERIC-RO study.
Most Relevant Research
Our investigation focused on the impact of iron deficiency in patients with worsening chronic heart failure, seeking clarity on how it affects their condition and recovery. We enrolled 163 patients from multiple centers who were hospitalized for this serious health issue. By evaluating iron deficiency at discharge, we distinguished those affected by low iron levels and compared various health indicators between groups.
We discovered that over half of the patients, 54.6%, had iron deficiency. Those with lower iron were more likely to exhibit signs of congestion and were categorized into more advanced heart failure classes. Interestingly, their levels of NT-proBNP, a crucial marker associated with heart failure, were significantly higher upon admission and didn’t improve much during their hospital stay.
While we found that mortality rates within 30 days had no significant difference between patients with and without iron deficiency, a notable increase in deaths was observed at 90 days post-discharge for those with iron deficiency. This suggests that iron levels could potentially influence recovery, especially in the longer term.
In conclusion, patients dealing with both chronic heart failure and iron deficiency showed more unresolved symptoms and poorer outcomes post-discharge. These findings highlight the importance of monitoring iron levels in patients facing heart issues, paving the way for future studies into treatment effectiveness and potential benefits of iron therapies.
We discovered that over half of the patients, 54.6%, had iron deficiency. Those with lower iron were more likely to exhibit signs of congestion and were categorized into more advanced heart failure classes. Interestingly, their levels of NT-proBNP, a crucial marker associated with heart failure, were significantly higher upon admission and didn’t improve much during their hospital stay.
While we found that mortality rates within 30 days had no significant difference between patients with and without iron deficiency, a notable increase in deaths was observed at 90 days post-discharge for those with iron deficiency. This suggests that iron levels could potentially influence recovery, especially in the longer term.
In conclusion, patients dealing with both chronic heart failure and iron deficiency showed more unresolved symptoms and poorer outcomes post-discharge. These findings highlight the importance of monitoring iron levels in patients facing heart issues, paving the way for future studies into treatment effectiveness and potential benefits of iron therapies.
10
Improved hemoglobin levels
Most Useful Review
Awesome additive! I ordered this iron supplement for my friend who suffers from muscle myositis and has low hemoglobin due to hormone treatment. She struggled with fatigue and muscle pain, despite trying various pharmacy drugs. After 3 months on this iron, her hemoglobin rose from 117 to 143, and she felt much better without any side effects. She even returned to work! Now, I’m taking it myself for prevention. Many thanks to the manufacturers!
Common Cold
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 14 Reviews
8.7
9.5
Cold symptoms alleviated
Most Useful Review
I cannot live without this! During childbirth, I suffered from a common cold, sore throat, and fever monthly. Despite numerous visits to the ENT department, I was desperate for relief. After learning I might be low in iron and zinc, I switched to Now Foods, which contains significantly more iron than others I'd tried. Initially, the smell made me gag, but I got used to it. I recommend purchasing from iHerb or Rakuten for better prices.
Depression
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
USERS' SCORE
Good
Based on 34 Reviews
8.7
7
Iron's Impact on Pregnancy Mental Health
Associations between iron status and psychosocial wellbeing among pregnant women in Cape Coast, Ghana: a longitudinal study.
Most Relevant Research
We set out to explore the connection between iron levels and mental health in pregnant women, focusing on how iron treatment may influence depressive symptoms. Our study recruited participants in their first trimester and followed them through their second and third trimesters, assessing their iron status and psychosocial wellbeing along the way.
Findings revealed that improvements in ferritin levels during the first and second trimesters were associated with fewer depressive symptoms and a better overall quality of life. This suggests that boosting iron levels in early pregnancy could potentially benefit mental health. Moreover, we discovered that increases in hemoglobin were linked to reduced anxiety, particularly feelings of fear, highlighting another positive aspect of improved iron status.
However, the results were more mixed in the later stages of pregnancy. While improvements in transferrin saturation from the second to the third trimester were connected to greater anxiety and a decline in quality of life, the initial positive effects underline the importance of monitoring and managing iron levels throughout pregnancy.
Overall, our findings hint at a beneficial relationship between iron status and psychosocial wellbeing, particularly in early pregnancy. However, more extensive studies are needed to confirm these promising results and better understand the nuances of this connection.
Findings revealed that improvements in ferritin levels during the first and second trimesters were associated with fewer depressive symptoms and a better overall quality of life. This suggests that boosting iron levels in early pregnancy could potentially benefit mental health. Moreover, we discovered that increases in hemoglobin were linked to reduced anxiety, particularly feelings of fear, highlighting another positive aspect of improved iron status.
However, the results were more mixed in the later stages of pregnancy. While improvements in transferrin saturation from the second to the third trimester were connected to greater anxiety and a decline in quality of life, the initial positive effects underline the importance of monitoring and managing iron levels throughout pregnancy.
Overall, our findings hint at a beneficial relationship between iron status and psychosocial wellbeing, particularly in early pregnancy. However, more extensive studies are needed to confirm these promising results and better understand the nuances of this connection.
8.8
Improved mood
Most Useful Review
I've been using this vitamin for a few months and my overall well-being has noticeably improved. My mood has enhanced, making it an excellent supplement for those who struggle with depression, as it offers varied health benefits, providing good value for money.
Menopause
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 24 Reviews
8.7
9
Iron treatment in menopause study
Deferasirox improved iron homeostasis and hematopoiesis in ovariectomized rats with iron accumulation.
Most Relevant Research
We investigated how iron treatment affects iron levels and blood production in rats that underwent ovariectomy, a procedure mimicking menopause. By using Deferasirox, a medication often prescribed for iron overload conditions, we aimed to understand its role in managing iron levels and supporting blood health in this context.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
9.5
Ferritin level increase
Most Useful Review
I started taking iron supplements when my ferritin was in the thirties. After three months, my level rose to the sixties, which I consider effective. I plan to continue taking it since my meals have not been sufficient, especially during menopause.
Tinnitus
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.7
9.5
Significant improvement
Most Useful Review
The anaemia issue has improved, and I no longer experience constipation. The price is reasonable. When taken with vitamin C, there's no discomfort while eating. Symptoms of dizziness and tinnitus caused by anaemia have significantly improved. Even postural hypotension has reduced. This iron supplement is much more affordable than the new ones recommended by the hospital that also avoid constipation. I will definitely repurchase.
Vertigo
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 7 Reviews
8.7
9
Iron treatment alleviates vertigo symptoms
Symptom panorama in upper secondary school students and symptoms related to iron deficiency. Screening with laboratory tests, questionnaire and interventional treatment with iron.
Most Relevant Research
Our study aimed to understand how iron deficiency impacts students' experiences, particularly focusing on symptoms like vertigo and dizziness. We set out to identify undiagnosed iron deficiency among first-grade students at an upper secondary school and evaluated changes in their symptoms and lab results after three months of iron supplementation.
Through our research, we found that 12% of the students had iron deficiency, and 61% exhibited some abnormal test results related to iron levels. Notably, we observed that symptoms of vertigo and dizziness were significantly more common in those with iron deficiency. After the students received iron supplementation, we recorded notable improvements: iron levels increased, transferrin levels decreased, and importantly, there was a marked reduction in symptoms, including vertigo, irritability, and depressive feelings.
Our findings convincingly highlight that iron supplementation can be beneficial in alleviating certain symptoms, specifically vertigo and dizziness, among students struggling with iron deficiency. This connection opens doors to addressing quality of life issues tied to iron levels among young individuals.
Through our research, we found that 12% of the students had iron deficiency, and 61% exhibited some abnormal test results related to iron levels. Notably, we observed that symptoms of vertigo and dizziness were significantly more common in those with iron deficiency. After the students received iron supplementation, we recorded notable improvements: iron levels increased, transferrin levels decreased, and importantly, there was a marked reduction in symptoms, including vertigo, irritability, and depressive feelings.
Our findings convincingly highlight that iron supplementation can be beneficial in alleviating certain symptoms, specifically vertigo and dizziness, among students struggling with iron deficiency. This connection opens doors to addressing quality of life issues tied to iron levels among young individuals.
9.5
Helps with vertigo
Most Useful Review
I bought this for my severe menstrual anaemia, and my son, who is also anemic, takes it with me. I haven't visited the hospital, but I've noticed that my dizziness has subsided since starting this supplement.
Chronic Cough
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Health benefits noted
Most Useful Review
Wonderful iron! A proper amount of iron ensures human health and safety due to its numerous benefits. Iron provides essential oxygen to the body's organs and plays a crucial role in forming red blood cells. It helps reduce anaemia, chronic cough, and various types of anaemia, including during pregnancy, and is vital for maintaining overall health and proper growth. Iron not only forms part of haemoglobin but also assists in transporting oxygen to the body's cells.
Ear Infection
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Good
Based on 1 Review
8.6
7
Iron deficiency links to ear infections
The association of iron deficiency anemia on chronic suppurative otitis media in children: A case-control study.
Most Relevant Research
We explored how iron deficiency anemia (IDA) may be linked to chronic suppurative otitis media (CSOM), a common ear infection affecting children. Our study involved children diagnosed with CSOM, who were compared to those with normal ear health. We examined various blood markers including hemoglobin levels and iron status to better understand the connection.
The findings revealed that children with CSOM had significantly lower iron levels and higher rates of anemia compared to those in the control group. Notably, 31% of the CSOM group exhibited IDA, while only 12% of the control group did. This suggests a notable association between IDA and the occurrence of ear infections in children.
Ultimately, while the study highlights the prevalence of IDA among children suffering from CSOM, it points toward the importance of monitoring iron levels in these patients to potentially reduce the incidence of ear infections.
The findings revealed that children with CSOM had significantly lower iron levels and higher rates of anemia compared to those in the control group. Notably, 31% of the CSOM group exhibited IDA, while only 12% of the control group did. This suggests a notable association between IDA and the occurrence of ear infections in children.
Ultimately, while the study highlights the prevalence of IDA among children suffering from CSOM, it points toward the importance of monitoring iron levels in these patients to potentially reduce the incidence of ear infections.
9.5
No more dizziness
Most Useful Review
Improved my anaemia. A friend mentioned it could help with dizziness and ear fluid imbalance. After a week, I no longer feel dizzy.
Cold Sores
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 1 Review
8.5
9
Iron therapy reduces cold sore frequency
Response to replacement iron therapy in sideropenic individuals with recrudescent herpes labialis.
Most Relevant Research
We investigated how iron replacement therapy affects the occurrence of cold sores, also known as recurrent herpes labialis, in people with low iron levels, a condition known as sideropenia. In our study, ten patients with confirmed sideropenia and a history of cold sores took ferrous sulphate for three months.
Before starting the treatment, these individuals reported experiencing an average of 0.78 episodes of cold sores each month. After the iron therapy, this number significantly dropped to just 0.2 episodes monthly. Furthermore, we found that there was a noteworthy increase in serum ferritin levels, a marker indicative of iron status, after treatment.
The results suggest that iron therapy may play a significant role in reducing the frequency of cold sores for those affected by iron deficiency. These findings are intriguing and warrant further exploration into iron supplementation as a potential option for managing cold sores in individuals with low iron levels.
Before starting the treatment, these individuals reported experiencing an average of 0.78 episodes of cold sores each month. After the iron therapy, this number significantly dropped to just 0.2 episodes monthly. Furthermore, we found that there was a noteworthy increase in serum ferritin levels, a marker indicative of iron status, after treatment.
The results suggest that iron therapy may play a significant role in reducing the frequency of cold sores for those affected by iron deficiency. These findings are intriguing and warrant further exploration into iron supplementation as a potential option for managing cold sores in individuals with low iron levels.
9
Cold sore relief
Most Useful Review
I cannot live without this product. During childbirth, I experienced cold sores along with a sore throat and fever each month, and despite numerous visits to the doctor, I was at my wit's end. I discovered I might be lacking in iron and zinc, and after starting this supplement, my symptoms vanished. Initially, I tried other brands but they contained little iron. Now Foods, which is significantly more potent and affordable, has worked wonders for me. Although the smell was initially off-putting, I soon got used to it.
Frozen Shoulder
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.5
9.5
Reduced stiffness
Most Useful Review
After five months postpartum, I experienced stiffness in my hands, which I feared was rheumatism. Upon discovering my iron levels were low, I tried megavitamin therapy, including 36mg of chelated iron alongside other vitamins. Now, I’m pleased to report that the frozen shoulder and stiffness have significantly eased, and I can tie my hair again.
Leg Cramps
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 26 Reviews
8.5
7
Iron treatment improves leg cramps
Iron deficiency associates with deterioration in several symptoms independently from hemoglobin level among chronic hemodialysis patients.
Most Relevant Research
We explored the effects of iron deficiency (ID) in patients on maintenance hemodialysis, especially regarding common symptoms like leg cramps. The study included 154 patients, all of whom had reached target hemoglobin levels, which means they were not anemic. This allowed us to focus on the impact of ID without the confounding factor of low hemoglobin.
Our findings revealed that patients with iron deficiency reported a higher severity of leg cramps compared to those without ID. Specifically, we observed that a low transferrin saturation (TSAT) level contributed significantly to the experience of pain during vascular access punctures and those annoying intradialytic leg cramps. Additionally, patients with lower ferritin levels faced more intense issues like severe fatigue and headaches during their dialysis sessions.
The results suggest that treating iron deficiency could potentially alleviate these critical symptoms, indicating that proactive iron supplementation may be beneficial for those undergoing maintenance dialysis. Addressing ID might not only improve hemoglobin levels but also enhance overall quality of life by reducing painful experiences like leg cramps.
Our findings revealed that patients with iron deficiency reported a higher severity of leg cramps compared to those without ID. Specifically, we observed that a low transferrin saturation (TSAT) level contributed significantly to the experience of pain during vascular access punctures and those annoying intradialytic leg cramps. Additionally, patients with lower ferritin levels faced more intense issues like severe fatigue and headaches during their dialysis sessions.
The results suggest that treating iron deficiency could potentially alleviate these critical symptoms, indicating that proactive iron supplementation may be beneficial for those undergoing maintenance dialysis. Addressing ID might not only improve hemoglobin levels but also enhance overall quality of life by reducing painful experiences like leg cramps.
9.5
Leg cramps improved
Most Useful Review
Excellent iron! I have low haemoglobin, and conventional options didn't work for me. After switching to this iron, the results were remarkable. My leg cramps disappeared, dizziness stopped, and my overall well-being improved. I take one tablet daily with food, avoiding tea and coffee before and after to enhance absorption. Highly recommend!
Anxiety
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 19 Reviews
8.4
7
Iron boosts mental health in pregnancy
Associations between iron status and psychosocial wellbeing among pregnant women in Cape Coast, Ghana: a longitudinal study.
Most Relevant Research
We examined how changes in iron levels during pregnancy relate to anxiety and overall wellbeing. The study followed pregnant women in Cape Coast, Ghana, tracking their iron status and psychological health throughout the first, second, and third trimesters.
Our findings indicate that improvements in iron levels from the first to the second trimester significantly reduced anxiety, especially concerning fearful feelings. The numbers showed that women who enjoyed better iron status experienced less anxiety, which suggests iron supplementation might play a helpful role in enhancing mental health during early pregnancy.
However, we also noted that as iron levels changed from the second to the third trimester, there was a surprising rise in anxiety. Despite initial improvements, some aspects of quality of life declined, indicating the complex relationship between iron status and mental wellbeing.
Overall, this study sheds light on the importance of monitoring and managing iron levels in expecting mothers, as it may impact not only physical health but also emotional wellbeing.
Our findings indicate that improvements in iron levels from the first to the second trimester significantly reduced anxiety, especially concerning fearful feelings. The numbers showed that women who enjoyed better iron status experienced less anxiety, which suggests iron supplementation might play a helpful role in enhancing mental health during early pregnancy.
However, we also noted that as iron levels changed from the second to the third trimester, there was a surprising rise in anxiety. Despite initial improvements, some aspects of quality of life declined, indicating the complex relationship between iron status and mental wellbeing.
Overall, this study sheds light on the importance of monitoring and managing iron levels in expecting mothers, as it may impact not only physical health but also emotional wellbeing.
7.5
Anxiety reduction
Most Useful Review
Upon starting this iron supplement, I noticed a warm feeling in my body and relief from anxiety and fatigue. Although I was initially alarmed by the black stools, I learned they are a normal effect of taking iron, which reassured me to continue.
Constipation
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6
USERS' SCORE
Good
Based on 220 Reviews
8.4
7
Iron's minimal effect on constipation
Low-Dose Prophylactic Oral Iron Supplementation (Ferrous Fumarate, Ferrous Bisglycinate, and Ferrous Sulphate) in Pregnancy Is Not Associated With Clinically Significant Gastrointestinal Complaints: Results From Two Randomized Studies.
Most Relevant Research
We explored the effects of low-dose iron supplementation on gastrointestinal complaints, particularly constipation, in pregnant women. Conducting two randomized studies, we aimed to determine how different forms of iron—ferrous fumarate, ferrous bisglycinate, and ferrous sulphate—would affect the frequency of GI issues among healthy women throughout their pregnancy.
Through our investigations, we found that constipation was only significantly associated with higher doses of ferrous fumarate (80 mg/day). Interestingly, women taking lower doses of ferrous fumarate (20-60 mg/day) did not report more GI side effects, indicating that manageable doses of iron may be tolerated without significant worry about constipation.
Among the iron formulas tested, ferrous bisglycinate at 25 mg showed the best profile, resulting in fewer GI complaints overall compared to the others. In fact, it was linked to a lower incidence of black stools, which can often be associated with iron intake. Ultimately, we observed that while low-dose iron supplementation might incur some side effects, they are generally not severe enough to warrant a change in dosage or interruption of treatment.
Through our investigations, we found that constipation was only significantly associated with higher doses of ferrous fumarate (80 mg/day). Interestingly, women taking lower doses of ferrous fumarate (20-60 mg/day) did not report more GI side effects, indicating that manageable doses of iron may be tolerated without significant worry about constipation.
Among the iron formulas tested, ferrous bisglycinate at 25 mg showed the best profile, resulting in fewer GI complaints overall compared to the others. In fact, it was linked to a lower incidence of black stools, which can often be associated with iron intake. Ultimately, we observed that while low-dose iron supplementation might incur some side effects, they are generally not severe enough to warrant a change in dosage or interruption of treatment.
9.5
No constipation noted
Most Useful Review
Strength and energy! This hardware is excellent. The quality surpasses what is found in pharmacies. It’s easy to take, doesn’t cause constipation and acts gently on the digestive tract. It's great for boosting haemoglobin levels and restoring energy.
Sleep Apnea
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 6 Reviews
8.4
8
Iron improves sleep apnea symptoms
Intravenous iron therapy improves the hypercapnic ventilatory response and sleep disordered breathing in chronic heart failure.
Most Relevant Research
We conducted a study to discover how intravenous iron therapy impacts sleep apnea in patients suffering from heart failure, anemia, and iron deficiency. Patients were randomly assigned to receive either ferric carboxymaltose or a placebo to assess changes in their sleep and respiratory function after treatment.
Our findings revealed that the intravenous iron treatment significantly improved the hypercapnic ventilatory response, which is the way our bodies react to increased carbon dioxide levels. We observed that, in particular, patients who received iron saw a notable reduction in their apneas and hypopneas—those moments when breathing stops or becomes shallow while asleep. Specifically, the apnoea-hypopnoea index dropped to an average of 12 events per hour with treatment, compared to 19 events per hour in the placebo group.
Furthermore, those who received iron also reported better overall symptoms and had improved physical capacity during exercise tests. This suggests that iron therapy not only helps with sleep-related breathing issues but may also boost oxygen delivery during physical activities.
Overall, our study supports the notion that iron therapy could play an important role in managing sleep apnea among patients with heart failure, providing them with enhanced breathing during sleep and better quality of life.
Our findings revealed that the intravenous iron treatment significantly improved the hypercapnic ventilatory response, which is the way our bodies react to increased carbon dioxide levels. We observed that, in particular, patients who received iron saw a notable reduction in their apneas and hypopneas—those moments when breathing stops or becomes shallow while asleep. Specifically, the apnoea-hypopnoea index dropped to an average of 12 events per hour with treatment, compared to 19 events per hour in the placebo group.
Furthermore, those who received iron also reported better overall symptoms and had improved physical capacity during exercise tests. This suggests that iron therapy not only helps with sleep-related breathing issues but may also boost oxygen delivery during physical activities.
Overall, our study supports the notion that iron therapy could play an important role in managing sleep apnea among patients with heart failure, providing them with enhanced breathing during sleep and better quality of life.
9.5
Eased restless legs
Most Useful Review
My husband suffers from restless leg syndrome, so I took this since I was advised it could help with iron deficiency. After taking one before bed, he was able to sleep well.
Athlete’s Foot
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.3
8.3
Resolved itching
Most Useful Review
My mother complained of itchy legs at night, which I discovered was due to an iron deficiency. I bought these supplements for her, and after just a few days, she stopped complaining about the itching associated with athlete’s foot.
Headache
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 49 Reviews
8.3
9.5
Gentle on stomach
Most Useful Review
I would definitely purchase these again. I feel much better after taking them. The iron does not upset my stomach or cause headaches. In fact, this supplement has been very gentle on my stomach, avoiding the usual issues I have with iron supplements. I would recommend these to anyone who is uncertain about iron supplements. The price is excellent with double strength composition!
Bone Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 25 Reviews
8.2
9.5
Improved wellbeing
Most Useful Review
I'm amazed by the results of this iron supplement! After struggling with low haemoglobin, my doctor recommended it. I opted for a chelative iron that is gentle on the stomach. After a month, my levels rose significantly, and I felt energised without experiencing any bone pain or other side effects. I highly recommend it!
Heartburn
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 17 Reviews
8.2
10
No heartburn experienced
Most Useful Review
I took this iron supplement during my pregnancy, alternating it with another medication. My haemoglobin levels remained normal, without the typical side effects of constipation or heartburn that I usually experience with iron supplements. The capsules were easy to swallow, and my stools did turn black, which is normal.
High Cholesterol
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.8
USERS' SCORE
Good
Based on 1 Review
8.2
8
Iron's influence on cholesterol levels
Association between exposure to plasma mixture of essential and toxic elements and the lipid profile in institutionalized older adults.
Most Relevant Research
We examined the relationship between essential and toxic elements in the plasma of institutionalized older adults and their cholesterol levels. Focusing on a group of 149 Brazilian seniors living in nursing homes, our goal was to understand how these elements influence lipid profiles and blood sugar levels.
Our findings indicated that lower concentrations of certain chemical elements, particularly iron, seemed to protect against increasing total cholesterol levels. We observed non-linear effects of iron, along with other elements like barium and copper, on triglyceride levels. Notably, when the concentration of these elements fell below a certain threshold, we found an associated decrease in total cholesterol.
These results suggest that monitoring the levels of these essential and toxic elements could be vital in preventing dyslipidemia—a condition characterized by abnormal lipid levels—and managing clinical interventions in older adults. The significant role of iron in influencing cholesterol levels emphasizes the need for continued research and screening in this population, to ensure that their health remains a top priority.
Our findings indicated that lower concentrations of certain chemical elements, particularly iron, seemed to protect against increasing total cholesterol levels. We observed non-linear effects of iron, along with other elements like barium and copper, on triglyceride levels. Notably, when the concentration of these elements fell below a certain threshold, we found an associated decrease in total cholesterol.
These results suggest that monitoring the levels of these essential and toxic elements could be vital in preventing dyslipidemia—a condition characterized by abnormal lipid levels—and managing clinical interventions in older adults. The significant role of iron in influencing cholesterol levels emphasizes the need for continued research and screening in this population, to ensure that their health remains a top priority.
5
Treating candida first
Most Useful Review
Transfer from CGN suddenly raised the price. Iron seems to act stronger than CGN. If I take iron and experience headaches or cravings for sweets, I stop immediately to manage Candida first. Iron encourages Candida growth. The author's advice on high-dose iron mentions intestinal issues like candida and SIBO, which can harm various organs. It's essential to listen to my body, determine my nutrient needs, and take control of my health regarding high cholesterol.
Liver Disease
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 20 Reviews
8.2
9
Rubiadin reduces liver iron overload
Rubiadin Mediates the Upregulation of Hepatic Hepcidin and Alleviates Iron Overload via BMP6/SMAD1/5/9-Signaling Pathway.
Most Relevant Research
We explored the effects of rubiadin, a beneficial compound derived from a Chinese herb, on iron metabolism and its implications for liver disease. Recognizing the challenges posed by iron overload diseases, we aimed to discover a safe approach to manage excessive iron accumulation in the body. Through experiments involving various analyses, we observed that rubiadin significantly downregulated proteins that are typically elevated in conditions of high iron, such as transferrin receptor 1 and ferroportin 1.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
9.5
Significant improvement
Most Useful Review
Awesome working additive! This iron supplement has notably improved my friend’s condition with liver disease. She struggled with low haemoglobin due to her medications. After taking this iron for three months, her haemoglobin rose significantly! Unlike other treatments, this one didn't cause nausea. She feels great now, and I’ve started it for prevention myself. Many thanks to the manufacturers!
Nausea
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 86 Reviews
8.2
9
Iron treatment eases nausea in pregnancy
Efficacy and Safety of Microsomal Ferric Pyrophosphate Supplement for Iron Deficiency Anemia in Pregnancy.
Most Relevant Research
We conducted a study to examine the effectiveness of a specific iron supplement, emulsified microsomal ferric pyrophosphate (EMFP), in treating iron deficiency anemia among pregnant women. Our focus was not only on improving hemoglobin levels but also on alleviating related symptoms, including nausea.
Within 30 days of starting treatment with EMFP, we observed significant increases in hemoglobin levels, alongside marked improvements in serum ferritin and iron levels. As nausea is a common complaint among pregnant women, we noted a decrease in various symptoms, including nausea, breathlessness, and dizziness, which contributed to a better quality of life for the participants.
Notably, treatment compliance was remarkably high at 99.5%, indicating that the participants were committed to managing their anemia effectively. Importantly, we did not encounter any severe side effects related to the treatment, suggesting a favorable safety profile.
Overall, our findings support the idea that iron treatment can help alleviate nausea and other discomforts related to iron deficiency anemia in pregnancy, positively impacting both mother and baby.
Within 30 days of starting treatment with EMFP, we observed significant increases in hemoglobin levels, alongside marked improvements in serum ferritin and iron levels. As nausea is a common complaint among pregnant women, we noted a decrease in various symptoms, including nausea, breathlessness, and dizziness, which contributed to a better quality of life for the participants.
Notably, treatment compliance was remarkably high at 99.5%, indicating that the participants were committed to managing their anemia effectively. Importantly, we did not encounter any severe side effects related to the treatment, suggesting a favorable safety profile.
Overall, our findings support the idea that iron treatment can help alleviate nausea and other discomforts related to iron deficiency anemia in pregnancy, positively impacting both mother and baby.
9.5
No nausea
Most Useful Review
Awesome working additive! I ordered this iron for a friend suffering from muscle myositis. She struggled with low haemoglobin and fatigue, trying various pharmacy drugs with nausea as a side effect. After taking this for 3 months, her haemoglobin rose from 117 to 143, and the product caused no nausea. She's feeling great at work now! I also ordered it for myself for preventative measures. Thank you to the manufacturers for such a wonderful product!
Bloating
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.4
USERS' SCORE
Good
Based on 11 Reviews
8.1
8
Iron treatment’s impact on bloating
Sucrosomial Iron Supplementation in Anemic Patients with Celiac Disease Not Tolerating Oral Ferrous Sulfate: A Prospective Study.
Most Relevant Research
We explored how iron supplementation impacts patients with celiac disease who suffer from iron deficiency anemia, particularly focusing on those unable to tolerate traditional iron sulfate. In this study, patients were divided into two groups: one receiving a new formulation called sucrosomial iron and the other taking iron sulfate.
After a 90-day follow-up, both groups showed significant improvements in hemoglobin levels and overall iron metrics. Interestingly, those taking sucrosomial iron experienced a marked reduction in abdominal symptoms like bloating and pain. They reported feeling a 33% increase in general well-being compared to 21% in the iron sulfate group.
This suggests sucrosomial iron could be a preferable option for individuals with celiac disease who struggle with gastrointestinal discomfort from standard iron treatments. Overall, while both forms of iron supplementation were effective, sucrosomial iron may ease some of the unpleasant side effects commonly associated with iron therapy.
After a 90-day follow-up, both groups showed significant improvements in hemoglobin levels and overall iron metrics. Interestingly, those taking sucrosomial iron experienced a marked reduction in abdominal symptoms like bloating and pain. They reported feeling a 33% increase in general well-being compared to 21% in the iron sulfate group.
This suggests sucrosomial iron could be a preferable option for individuals with celiac disease who struggle with gastrointestinal discomfort from standard iron treatments. Overall, while both forms of iron supplementation were effective, sucrosomial iron may ease some of the unpleasant side effects commonly associated with iron therapy.
9.5
No bloating experienced
Most Useful Review
After using two cans, my ferritin levels doubled! I continue to take them regularly with no bloating or discomfort. I highly recommend these.
Heart Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.9
9
Iron treatment effects on heart
Ironing Out the Controversies Surrounding the Iron Deficiency Definition in Heart Failure.
Most Relevant Research
We investigated the role of iron treatment in managing heart disease, particularly its isolated effects. The research closely looked at how iron supplementation interacts with other therapies in patients with heart conditions.
Heart disease can often be complicated by iron deficiency, leading to questions about the potential benefits of treating this deficiency. Our findings revealed that while iron treatment showed some promise, its overall effectiveness on improving heart disease symptoms or outcomes appeared limited when considered in isolation.
Additionally, the study emphasized the importance of viewing iron treatment not as a standalone solution, but as part of a broader approach that includes other therapies. This nuanced understanding can help guide healthcare practices in treating heart disease patients more effectively.
Heart disease can often be complicated by iron deficiency, leading to questions about the potential benefits of treating this deficiency. Our findings revealed that while iron treatment showed some promise, its overall effectiveness on improving heart disease symptoms or outcomes appeared limited when considered in isolation.
Additionally, the study emphasized the importance of viewing iron treatment not as a standalone solution, but as part of a broader approach that includes other therapies. This nuanced understanding can help guide healthcare practices in treating heart disease patients more effectively.
8.8
Improved energy levels
Most Useful Review
I had been suffering from anaemia, feeling constantly fatigued and with low blood pressure. My ferritin level was shockingly low at 7. After starting on iron supplements, I noticed significant improvements within weeks. My dizziness and low blood pressure improved to 110/70, and my ferritin has increased to 35. I wholeheartedly recommend this product!
Irritable Bowel Syndrome
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.8
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.7
4
Iron Supplementation and Gut Microbiota
The Impact of Low-Level Iron Supplements on the Faecal Microbiota of Irritable Bowel Syndrome and Healthy Donors Using In Vitro Batch Cultures.
Most Relevant Research
We explored how low-level iron supplementation impacts the gut microbiota in individuals with Irritable Bowel Syndrome (IBS) and in healthy donors. To do this, we conducted anaerobic, pH-controlled in vitro batch cultures using fecal samples from both groups, supplemented with various forms of iron, including ferrous sulphate, nanoparticulate iron, and pea ferritin.
Our findings revealed that IBS participants had distinct microbial profiles compared to their healthy counterparts. Interestingly, we observed that the different sources of iron we used did not have a negative effect on the overall microbial populations. Both pea ferritin and nanoparticulate iron showed similar outcomes, while ferrous sulphate appeared to enhance certain beneficial bacteria.
Additionally, we measured the production of metabolites and found that there was no harmful shift towards increased proteolysis. These results suggest that low doses of iron from the three sources tested are unlikely to be detrimental to the gut microbiota, giving us new insights into the potential for iron supplementation in managing gut health, especially for those with IBS.
This is the first time we've tested fermentation of pea ferritin, which adds an exciting dimension to our understanding of dietary iron sources and gut health.
Our findings revealed that IBS participants had distinct microbial profiles compared to their healthy counterparts. Interestingly, we observed that the different sources of iron we used did not have a negative effect on the overall microbial populations. Both pea ferritin and nanoparticulate iron showed similar outcomes, while ferrous sulphate appeared to enhance certain beneficial bacteria.
Additionally, we measured the production of metabolites and found that there was no harmful shift towards increased proteolysis. These results suggest that low doses of iron from the three sources tested are unlikely to be detrimental to the gut microbiota, giving us new insights into the potential for iron supplementation in managing gut health, especially for those with IBS.
This is the first time we've tested fermentation of pea ferritin, which adds an exciting dimension to our understanding of dietary iron sources and gut health.
9.5
No discomfort noted
Most Useful Review
Excellent iron dosage! I take it with vitamin C. This iron is very gentle; my digestive tract has experienced no discomfort, only darker stools. It’s a great product at a low price with excellent quality, and my bowels function well while taking this supplement.
Colitis
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
9
Dietary iron aids intestinal recovery
Dietary Iron Alleviates Dextran Sodium Sulfate-Induced Intestinal Injury by Regulating Regeneration of Intestinal Stem Cells in Weaned Mice.
Most Relevant Research
We investigated the role of dietary iron in recovery from colitis, specifically focusing on its effects in weaned mice. The study involved two groups of mice fed different diets: one with a regular amount of iron and another enriched with significantly more iron. After two weeks on their respective diets, both groups were subjected to dextran sodium sulfate (DSS) treatment to induce colitis.
Throughout the recovery phase, we observed that the iron-enriched diet proved especially beneficial for the weaned mice. By day three of recovery, those on the iron diet showed less weight loss, shorter colon lengths, and less damage to intestinal structure compared to their counterparts. Iron not only promoted the vitality of intestinal stem cells but also helped maintain the integrity of the intestinal lining.
Furthermore, analyses of organoids revealed that the iron diet stimulated the expression of certain genes involved in differentiation and metabolism, which suggests a deeper mechanism at play. Overall, this study indicates that dietary iron may significantly enhance the repair of intestinal injuries and support the regeneration of healthy tissue following inflammation.
Throughout the recovery phase, we observed that the iron-enriched diet proved especially beneficial for the weaned mice. By day three of recovery, those on the iron diet showed less weight loss, shorter colon lengths, and less damage to intestinal structure compared to their counterparts. Iron not only promoted the vitality of intestinal stem cells but also helped maintain the integrity of the intestinal lining.
Furthermore, analyses of organoids revealed that the iron diet stimulated the expression of certain genes involved in differentiation and metabolism, which suggests a deeper mechanism at play. Overall, this study indicates that dietary iron may significantly enhance the repair of intestinal injuries and support the regeneration of healthy tissue following inflammation.
0
Damaging colitis effects
Most Useful Review
If you have active colitis, I advise you to avoid this product completely. It absolutely destroyed my gut.
Diarrhea
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6.7
USERS' SCORE
Medium or Average
Based on 36 Reviews
6.7
9
Iron enhances piglet gut health
Dietary Fe-Gly supplementation attenuates enterotoxigenic (ETEC)-induced inflammation response and intestinal barrier dysfunction in piglets.
Most Relevant Research
We explored how adding iron, specifically Fe-Gly, to piglets' diets could help combat diarrhea caused by enterotoxigenic E. coli (ETEC) infections. In our study, we administered 50 mg of Fe-Gly to weaned piglets that had been infected, monitoring their growth, diarrhea rates, and overall gut health.
We observed remarkable improvements in the piglets' growth performance, with increases in average daily feed intake and daily gain by over 30%. Most notably, the rate of diarrhea significantly decreased by 40%. Additionally, we found that this iron supplementation raised the levels of total iron binding capacity in piglet serum, suggesting better iron transport and utilization.
Beyond growth metrics, the addition of Fe-Gly also showed potential in alleviating intestinal damage incurred from the ETEC challenge. As a result, we conclude that Fe-Gly not only meets daily iron needs but also reduces the iron available for harmful gut bacteria, promoting better intestinal health in piglets suffering from infections.
We observed remarkable improvements in the piglets' growth performance, with increases in average daily feed intake and daily gain by over 30%. Most notably, the rate of diarrhea significantly decreased by 40%. Additionally, we found that this iron supplementation raised the levels of total iron binding capacity in piglet serum, suggesting better iron transport and utilization.
Beyond growth metrics, the addition of Fe-Gly also showed potential in alleviating intestinal damage incurred from the ETEC challenge. As a result, we conclude that Fe-Gly not only meets daily iron needs but also reduces the iron available for harmful gut bacteria, promoting better intestinal health in piglets suffering from infections.
9.5
No issues noted
Most Useful Review
Excellent hardware! I occasionally take iron as my ferritin levels were found to be low (17). This iron is gentle on my gastrointestinal tract and does not cause diarrhoea. Previously, I used Solgar's soft iron, but this has a better dosage of 36 mg instead of 25 mg, which is more effective. It’s best taken with vitamin C or B vitamins for better absorption. I recommend it for those with low ferritin, pregnant or lactating women, and menstruating women.
Blood Clot
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.5
USERS' SCORE
Medium or Average
Based on 7 Reviews
6.5
9
ESA and iron enhance surgery outcomes
Use of preoperative erythropoietin-stimulating agents is associated with decreased thrombotic adverse events compared to red blood cell transfusion in surgical patients with anaemia.
Most Relevant Research
We aimed to understand how preoperative treatments like erythropoietin-stimulating agents (ESAs) and intravenous (IV) iron influence the risk of blood clots in surgical patients dealing with anaemia.
In our investigation, we found that patients who received ESAs—whether accompanied by IV iron or not—had lower risks of serious post-operative complications, including blood clots, compared to those who were given red blood cell transfusions. Specifically, those treated with ESAs without IV iron showed significant reductions in mortality and the occurrence of venous thromboembolic events.
Interestingly, when IV iron was combined with ESAs, it appeared to further enhance outcomes, notably improving survival rates. Our results suggest that combining these treatments might yield benefits for patients undergoing surgery, reflected in higher haemoglobin levels and fewer complications compared to traditional blood transfusions.
In our investigation, we found that patients who received ESAs—whether accompanied by IV iron or not—had lower risks of serious post-operative complications, including blood clots, compared to those who were given red blood cell transfusions. Specifically, those treated with ESAs without IV iron showed significant reductions in mortality and the occurrence of venous thromboembolic events.
Interestingly, when IV iron was combined with ESAs, it appeared to further enhance outcomes, notably improving survival rates. Our results suggest that combining these treatments might yield benefits for patients undergoing surgery, reflected in higher haemoglobin levels and fewer complications compared to traditional blood transfusions.
9.5
Positive improvement
Most Useful Review
For a while, I struggled with severe anaemia, receiving blood-thinning injections twice a week, and taking agents to increase my blood. Recently, I experienced dizziness and noticed my lower eyelids turning white, prompting me to start this medicine. After three weeks, my eyelid colour improved to red, which I believe indicates a significant effect.
