NOW Supplements

Zinc supplementation benefits MS models

Based on 6 Researches

Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model.

Most Relevant Research

We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.

9.5

Improved well-being

Most Useful Review

I have been taking this vitamin for a few weeks and noticed a significant improvement in my overall health and mood. I struggled with an autoimmune disorder for over six years until starting this supplement. My energy levels are up, my mood has improved, and I feel capable of taking on anything.

Chronic Fatigue Syndrome

Zinc supplementation may benefit CFS

Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS.

Most Relevant Research

We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.

Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.

Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.

9.5

Increased energy levels

Most Useful Review

I had been suffering from chronic fatigue syndrome for months when I tried this amazing vitamin. Within a few days, I noticed a significant increase in my energy, allowing me to exercise without problems. This supplement is cost-effective and has greatly improved my quality of life.

Cold Sores

Zinc cream alleviates cold sores

Based on 9 Researches

A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine.

Most Relevant Research

We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.

Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.

As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.

9.5

Helps with colds

Most Useful Review

At the first signs of a cold, this product helps significantly; I recover in 4-5 days with vitamin C and D3.

Back Pain

Zinc may boost bone density

Based on 2 Researches

Treatment for osteoporosis in people with beta-thalassaemia.

Most Relevant Research

We explored how zinc supplementation might help with back pain in individuals with beta-thalassaemia. The research included a randomized controlled trial with 42 participants, where some received zinc while others were given a placebo.

Results showed that zinc supplementation likely increased the bone mineral density (BMD) at the lumbar spine and hip after 12 to 18 months of treatment. This improvement in bone health could suggest potential benefits in pain relief, although the study didn’t directly measure back pain outcomes.

Even though the findings about BMD improvements are promising, we should be cautious. The trial didn't provide direct evidence on whether zinc specifically alleviates back pain. It’s essential to recognize that while we observed positive changes in bone density, interpreting this as a definitive solution for back pain would be premature.

Thus, further research is necessary to connect zinc's effects on bone health to actual pain relief in order to offer clearer guidance on its use as a treatment for back pain.

9.5

Reduced pain

Most Useful Review

With chronic prostatitis, this is my go-to supplement. It has significantly reduced my pain and improved sperm quality, while zinc has increased my free testosterone levels. I highly recommend it to anyone suffering from chronic issues. Research shows that zinc levels in prostate secretion decrease with prostatitis, necessitating supplementation.

Bloating

Improved stomach condition

Most Useful Review

After three months of taking one softgel on an empty stomach, I've noticed improvements in my facial skin and less oiliness in my skin and hair. My plasma zinc levels increased, and I will continue using this product. It’s a potent and cost-effective form of zinc with no stomach pain or bloating.

Eczema

Zinc enhances eczema recovery

Transient symptomatic zinc deficiency in an exclusively breastfed infant.

Most Relevant Research

We investigated the relationship between zinc deficiency and eczema in a 3-month-old infant who was exclusively breastfed. The infant presented with symptoms like scaling erythematous dermatitis affecting her face and other areas, alongside irritability and poor weight gain. Her mother had been taking isoniazid for tuberculosis during pregnancy, which possibly contributed to the infant’s zinc deficiency.

After initial treatments for a suspected skin infection didn’t bring any changes, we found that the baby had low serum zinc levels and low zinc concentration in her breast milk. This led us to believe the skin condition was due to zinc deficiency rather than an infection. We started zinc supplementation, and the infant showed remarkable improvement in her skin condition and weight.

By 6 months, the infant had begun eating solid food, and we stopped the zinc supplements, with no signs of eczema returning. This case underscores the importance of monitoring zinc levels in breastfed infants, especially when mothers are on specific medications that might impact nutrient transfer through breast milk.

9.5

Eczema relief

Most Useful Review

Zinc protects skin membranes, alleviates sore throats, and has antioxidant effects, making it valuable for women. I particularly took it during summer and when I experienced severe eczema.

Erectile Dysfunction

Zinc improves erectile dysfunction

Effect of oral zinc therapy on gonadal function in hemodialysis patients. A double-blind study.

Most Relevant Research

We observed the effects of zinc on erectile dysfunction in a carefully designed study that involved a double-blind trial. Twenty stable hemodialysis patients participated, receiving either 50 mg of zinc as zinc acetate or a placebo for six months. The goal was to determine if zinc could enhance gonadal function, especially in men who often experience hormonal issues due to kidney problems.

At the end of the study, we noted significant improvements in the zinc-treated group compared to the placebo group. Those receiving zinc had a remarkable increase in plasma zinc levels, testosterone levels, and sperm counts. Specifically, testosterone levels rose from 2.8 to 5.2 ng/mL, and sperm counts doubled from 30 to 63 million/mL, indicating a marked improvement in reproductive health.

Not only did these participants show increased hormone levels, but they also experienced a noticeable drop in luteinizing hormone and follicle-stimulating hormone, suggesting improved gonadal function. Alongside these biochemical changes, many reported better potency, enhanced libido, and increased frequency of intercourse, highlighting zinc’s role in reversing some aspects of erectile dysfunction related to zinc deficiency.

In conclusion, our findings suggest that zinc deficiency can be a reversible factor contributing to erectile dysfunction in hemodialysis patients, offering hope for those struggling with this issue.

8.8

Improved testosterone level

Most Useful Review

Zinc is essential for maintaining a normal testosterone level. Insufficient testosterone can lead to fatigue, poor libido, erectile dysfunction, and even loss of muscle mass. Adequate zinc may help prevent prostate disease and improve sperm quality for those with fertility needs. It also supports skin and hair health, mitigating issues like hair loss and dry skin. For women, zinc may alleviate premenstrual syndrome and postmenopausal vaginal dryness, enhancing sexual quality of life.

Hashimoto

Zinc's link to Hashimoto's thyroiditis

Based on 2 Researches

Association Between Essential Trace Elements and Thyroid Antibodies in the Blood of Women with Newly Diagnosed Hashimoto's Thyroiditis.

Most Relevant Research

We explored the connection between essential trace elements, particularly zinc, and Hashimoto’s thyroiditis (HT) in women who were newly diagnosed. In this study, we looked at a group of 56 women with HT and compared them to 64 matched controls.

The results showed that women with HT had significantly lower levels of selenium, iron, and zinc in their blood compared to the controls. Interestingly, their copper levels were higher. We examined the relationships between these trace elements and thyroid autoantibodies, which can indicate the presence of autoimmune activity affecting the thyroid.

While we noted a significant correlation between lower zinc (and other elements) and higher levels of thyroid antibodies, the study did not specifically focus on zinc treatment. This means that while zinc levels appear to be linked to autoantibody levels in HT, we can't definitively state that zinc treatment will improve the condition without further dedicated research.

Overall, the study indicates that lower zinc levels in conjunction with selenium and iron deficiencies might be involved in the autoimmune response seen in Hashimoto’s thyroiditis. Thus, this provides an avenue for future exploration into zinc's role as a potential supplement for women diagnosed with this condition.

9.5

Must-have supplement

Most Useful Review

Excellent quality! This is a must-have for anyone with Hashimoto's disease, as it contains safe ingredients.

Influenza

Zinc may prevent influenza entry

Based on 2 Researches

Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry.

Most Relevant Research

We investigated how zinc, delivered through epipharyngeal abrasive therapy (EAT), might impact the expression of a key molecule known as Cav1.2, which plays a crucial role in allowing the influenza A virus to enter cells. The study included two groups of patients: one group that received EAT, which involved scratching the epipharyngeal mucosa with a zinc chloride-treated swab, and another group that did not receive this treatment.

By analyzing tissue samples, we observed that the levels of Cav1.2 were significantly lower in the EAT-treated patients compared to those who were not treated. In fact, the expression of Cav1.2 in the patients who underwent EAT was measured to be 4.19 times lower than in the non-treated group. This suggests that the squamous metaplasia induced by EAT might help reduce the entry of the influenza virus by down-regulating this key protein.

Our findings indicate that EAT, through its zinc content, could serve as a simple and effective method to potentially prevent influenza infection by limiting the virus's ability to enter cells.

9.5

Highly effective protection

Most Useful Review

This product truly works. I usually refrain from writing reviews, but have purchased this zinc for the third time. It remarkably protects my family from seasonal illnesses, including influenza. I've noticed we get sick less often. During this pandemic, we take it daily.

A systematic review of the association between zinc and anxiety.

Most Relevant Research

We explored the connection between zinc intake and anxiety in adults through a systematic review of nine original studies. Two of these studies looked at how zinc consumption impacts anxiety, while the other seven focused on the relationship between serum zinc levels and anxiety symptoms. Our analysis included studies published in English within peer-reviewed journals, ensuring a solid foundation for understanding this potential link.

What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.

In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.

8.8

Reduced anxiety

Most Useful Review

My anxiety has decreased since I started taking this zinc supplement, which helps balance my copper levels from drinking excess cocoa. Other zinc supplements caused me stomach issues, but this one is easier on my stomach and aids in keeping me calm. It’s well-absorbed, and I’d definitely consider repurchasing it.

Diarrhea

Zinc oxide mitigates diarrhea impacts

Zinc Oxide Administration Relieves the Diarrhea of ETEC K88-Infected Piglets by Reducing Ileal Apoptosis and Maintaining Gut Microbial Balance.

Most Relevant Research

We explored how zinc oxide (ZnO), often used as a feed additive, affects diarrhea and gut health in piglets infected with the ETEC K88 strain. Through careful observation, we found that piglets suffering from this infection exhibited significantly increased fecal scores compared to those not affected. The ETEC K88 strain harms the small intestine, leading to a loss of villus height and a decrease in important antioxidant activities.

Our findings revealed that ZnO administration counteracts these negative effects effectively. It not only improved the overall health of the intestine but also enhanced its ability to combat oxidative stress. We also observed a balanced restoration of gut microbiota, as ZnO helped normalize the populations of certain beneficial bacteria altered by the infection.

In summary, our study indicates that ZnO can play a vital role in easing diarrhea in piglets infected with ETEC K88 by reducing intestinal damage, supporting antioxidative defenses, and restoring healthy gut flora.

8.8

Effective absorption

Most Useful Review

Absorbs well. I bought this for my husband, as zinc gluconate caused him diarrhoea. This form of zinc works effectively.

Gastritis

Zinc protects against gastritis damage

Based on 8 Researches

Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model.

Most Relevant Research

We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.

Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.

Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.

9.5

No gastritis worries

Most Useful Review

Good zinc in a suitable dosage. Since taking it, I've not caught any colds and my hair growth has improved. I'm no longer concerned about gastritis.

Hypothyroidism

Zinc's uncertain role in hypothyroidism

The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial.

Most Relevant Research

We conducted a study to investigate the effects of micronutrient supplementation, including zinc, on thyroid function and overall quality of life in patients with hypothyroidism. Our trial involved 104 participants who were receiving levothyroxine and vitamin D. They were randomly assigned to either a group that received a mix of essential nutrients or a placebo group over eight weeks.

We measured various health markers before and after this period, including thyroid hormone levels, cholesterol, insulin resistance, and blood pressure. Our findings suggested that the group receiving the micronutrient supplement experienced improvements in insulin resistance and overall quality of life. However, it’s important to note that the specific effects of zinc alone are somewhat difficult to isolate, as it was part of a combination of nutrients being tested.

Ultimately, while the study indicates potential benefits of micronutrient supplementation for thyroid function in hypothyroid patients, further trials are necessary to clearly define the role of zinc and other nutrients in this context.

9.5

Health improvement

Most Useful Review

After three months of taking this zinc for my hypothyroidism, my condition has improved. I will continue using it alongside other vitamins and minerals. Zinc is crucial for numerous bodily functions.

Irritable Bowel Syndrome

Likely Ineffective

Zinc intake may reduce IBS risk

Dietary copper, zinc, copper/zinc ratio intakes and irritable bowel syndrome risk: a large-scale prospective cohort study from UK Biobank.

Most Relevant Research

We explored the potential connection between dietary zinc intake and the risk of developing irritable bowel syndrome (IBS) through a large-scale analysis of participants from the UK Biobank. By assessing the dietary habits of 175,421 individuals who did not have IBS at the start of the study, we sought to understand how various levels of zinc, as well as copper and their ratio, might influence the onset of this troublesome condition.

Over an average follow-up period of 13.3 years, we observed that 2,240 participants were diagnosed with new-onset IBS. Notably, our findings revealed a U-shaped relationship between zinc intake and IBS incidence. For those consuming less than 10 mg of zinc per day, an increase in intake was linked to a decreased risk of IBS. Specifically, individuals taking less than 10 mg of zinc daily experienced a reduced risk with higher zinc consumption.

However, the relationship shifted for individuals who had higher intakes of copper and zinc; no significant benefits were noted when intakes reached or exceeded established thresholds. This suggests that there's a delicate balance to maintain when it comes to zinc and copper in the diet.

Importantly, subgroup analysis indicated that younger individuals, particularly those under 60, could benefit more from slight increases in zinc. Overall, our study highlights the significance of dietary management, emphasizing that reasonable zinc intake may contribute to lowering IBS risk while keeping copper and the copper/zinc ratio in a sensible range.

9.5

Supports immunity

Most Useful Review

I have been using Zinc Glycinate from Now Foods for a long time. Zinc is essential for health, affecting immunity, the nervous system, and bones. A deficiency can lead to issues such as frequent colds, irritable bowel syndrome, and hair loss. This product is of excellent quality, and I am satisfied with its content and effectiveness. I certainly recommend it before making a purchase!

Leg Cramps

Improves sleep quality

Most Useful Review

I absolutely love this magnesium from NOW. It's my third bottle and it significantly helps with my sleep and leg cramps. I take two capsules about one and a half hours before bed, and my sleep has greatly improved. This product works well alongside Vitamin D3+K2. Always remember to do your own research first!

Migraine

Zinc reduces migraine symptoms

Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women.

Most Relevant Research

This study was designed as a randomized double-blind, placebo-controlled trial to examine how zinc gluconate supplementation might alleviate migraine symptoms in adult women. We followed 60 women, averaging about 35 years old, who either received 15 mg of zinc per day or a placebo for a duration of 12 weeks.

Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.

Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.

Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.

9.5

Migraine relief

Most Useful Review

Great! It normalises sleep (with regular intake of 2 capsules) and improves my migraines. When special effects begin, I take the pills and add extra magnesium, which smoothens my migraine within a couple of hours. The frequency has also decreased, and magnesium helps alleviate PMS and menstruation. Chronic nasopharynx pain hardly worsens. While I’m taking omega-3 and other supplements, magnesium's role is significant. There were no allergies or stomach issues. The quality is excellent, with natural ingredients that have a beneficial influence on health.

Osteoporosis

Zinc intake may protect bones

Based on 10 Researches

The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis.

Most Relevant Research

We investigated the connection between dietary zinc intake and the prevalence of osteoporosis and osteopenia in patients with rheumatoid arthritis (RA). Using data from the National Health and Nutrition Examination Survey collected over several years, we applied various statistical methods to analyze how zinc impacts bone health in these patients.

Our findings revealed that higher dietary zinc intake appears to be linked with a lower incidence of osteopenia and osteoporosis among individuals with RA. This suggests that consuming adequate amounts of zinc might support better bone health for those suffering from this chronic condition.

Despite our positive findings, we acknowledge that further research, including longitudinal and randomized trials, is essential for confirming these results and understanding the underlying mechanisms at play. However, the evidence from our analysis encourages a focus on dietary zinc as a possible factor in maintaining bone health for patients with RA.

9.5

Helpful for osteoporosis

Most Useful Review

With advanced osteoporosis, this supplement effectively meets my needs, just as I expect from the "Now" brand.

Sleep Apnea

Zinc protects heart function in OSA

Zinc Is Indispensable in Exercise-Induced Cardioprotection against Intermittent Hypoxia-Induced Left Ventricular Function Impairment in Rats.

Most Relevant Research

We explored how zinc affects heart function in the context of obstructive sleep apnea (OSA), specifically focusing on cases of intermittent hypoxia (IH). In a detailed study using male rats, researchers set up different groups: a control group and one that underwent 10 weeks of exercise training. Half of the rats in both groups were exposed to IH conditions to simulate the effects of sleep apnea.

The results were eye-opening. Rats that experienced IH showed notable impairment in their heart's left ventricular function, characterized by reduced ejection fraction and increased inflammation. However, when treated with zinc, these negative effects were significantly countered. Notably, those who exercised and received zinc treatment displayed improved heart function and antioxidant capabilities compared to their counterparts that did not receive zinc.

On the flip side, exercise alone did not provide the same protective benefits when zinc was absent. The findings suggest that zinc is essential not only for the heart's protection against the damaging effects of IH but also enhances the benefits of physical exercise. This research indicates the importance of zinc in potentially managing heart health in individuals suffering from sleep apnea.

9.5

Life-changing improvement

Most Useful Review

I had a severe sleep disorder and can now sleep soundly! I'm incredibly grateful to have discovered this solution after years of relying on powerful prescribed medications. With the help of supplements like melatonin and zinc, I’m finally experiencing stable sleep. The combination of vitamin D and magnesium has enhanced my sleep quality tremendously. As my sleep improves, my overall health is returning, and it’s a joy to regain my vitality after feeling unwell for so long!

Whooping Cough

I strongly recommend this product, especially for mothers with children. As soon as my child began to snot, I immediately gave him zinc in the morning and it vanished. I had a cough myself, started on zinc, and it disappeared like magic. It’s a fantastic product!

Acne

Zinc effective for acne treatment

Based on 16 Researches

Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis.

Most Relevant Research

We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.

Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.

Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!

9.5

Reduced grease

Most Useful Review

I've struggled with excessively oily skin and acne since my teens. After trying various treatments, I discovered zinc deficiency could be linked to my problem. I ordered zinc, and after just three days, my scalp and face became less oily, and the pimples I'd expect during PMS vanished. I also experienced less painful menstruation. This has had a positive effect so far.

Alzheimer

Zinc compound shows promise in Alzheimer

Based on 5 Researches

Carboxylated Zn-phthalocyanine attenuates brain Aβ in AD model mouse.

Most Relevant Research

We explored how a carboxylated zinc compound, known as Zn-phthalocyanine (ZnPc), impacts Alzheimer’s disease by examining its effects on amyloid beta (Aβ) deposition in a specific mouse model. Over a 12-week period, we administered weekly injections of ZnPc to older J20 mice, carefully assessing their cognitive abilities through various behavioral tests. Early findings showed that this zinc-based treatment significantly improved learning and memory in these mice.

We found that ZnPc accumulated in the brain and effectively reduced levels of Aβ both within neurons and in surrounding areas. Notably, neuronal health appeared to improve as more neurons were observed in regions of the brain crucial for memory, like the cortex and hippocampus. The treatment also reduced harmful inflammatory responses, as indicated by fewer activated astrocytes and microglia, which are often involved in neurodegeneration.

Furthermore, improvements were noted in blood vessel integrity and overall brain structure, suggesting that ZnPc not only targets Aβ but also supports broader neurological health. In summary, our results propose that ZnPc may serve as a promising therapeutic agent for Alzheimer’s disease, emphasizing the potential of zinc and its compounds in addressing neurodegenerative issues.

8.8

Essential for Alzheimer

Most Useful Review

I regularly take this chelated zinc because the price is reasonable, and the quality is comparable to more expensive brands. This form is the most digestible. Zinc is vital for the nervous system's functioning, so it is important to take it with Parkinson's and Alzheimer.

Bone Pain

Excellent zinc supplement, vital for both adults and children. A deficiency can lead to developmental issues in youth. It plays a crucial role in metabolism, strengthens immunity, and has strong antioxidant qualities. My own experience with zinc has shown improvement in treating bone pain alongside supporting overall health.

Chronic Cough

I've been taking this vitamin for a while, and I’m pleased to say I haven't been as ill. The information I found indicated it’s excellent for colds and flu. My chronic cough has lessened, and my appetite has improved.

Depression

Zinc deficiency impacts brain function

Proteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency.

Most Relevant Research

We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.

We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.

Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.

These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health.

8.8

Improved condition

Most Useful Review

It initially seemed easy to feel depressed, but after taking zinc regularly, my condition improved significantly. While I had some emotional instability before my period, taking zinc daily has helped alleviate my pre-menstrual mental symptoms greatly. I appreciate that these supplements are smaller and easier to take than many overseas products.

Heart Disease

Zinc benefits heart health post-cisplatin

Based on 4 Researches

Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats.

Most Relevant Research

We explored the potential benefits of zinc oxide nanoparticles (ZnONPs) in preventing heart damage caused by cisplatin, a powerful chemotherapy drug known for its efficacy but also for its side effects, particularly cardiotoxicity.

In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.

As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.

Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.

9.5

Supports heart health

Most Useful Review

A highly effective source of zinc glycinate for prostate health. Zinc aids in sex hormone synthesis and spermatogenesis, crucial for improving sexual health and prostate function while protecting against diseases and supporting anabolic hormone production.

Heartburn

Zinc's role in heartburn relief

Esophageal ulcer related to zinc deficiency following a total gastrectomy.

Most Relevant Research

We investigated how zinc affects heartburn through the case of a 76-year-old Japanese man who experienced significant discomfort after undergoing a total gastrectomy. For two weeks, he suffered from a sore throat, heartburn, and difficulty swallowing. Endoscopy revealed deep, craterlike ulcers in his esophagus, but tests for viral infections were negative.

After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.

Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.

9.5

Heartburn improvement

Most Useful Review

Easy to take with a soft gel. As a man in my 40s, I take 1 tablet daily after meals. If I experience heartburn, I take it with a vitamin C capsule, which helps improve my energy. I noticed my erections became firmer after taking it.

Hives

Zinc insulin alleviates hives

Chronic urticaria from isophane insulin therapy; sensitivity associated with noninsulin components in commercial preparations.

Most Relevant Research

We observed a fascinating case of a young woman with diabetes who experienced chronic hives after switching her insulin type. Initially, she moved from a standard isophane insulin to a beef-pork version, which then triggered her hives. Even after she returned to her original insulin, the hives continued to be a problem.

During her hospital stay, we noted that her hives reappeared daily after insulin injections. This situation changed when we introduced a purer form of insulin called zinc single-peak beef insulin suspension. Surprisingly, the urticaria cleared up quickly after this switch.

Through skin testing, we discovered her sensitivity was primarily to the beef and pork forms of the isophane insulin. However, she showed no sensitivity to the zinc insulin forms. Although she did experience a brief return of the hives after taking antibiotics, this time they did not reappear at the insulin injection sites.

This case provides valuable insight into how certain insulin components can lead to hives, and how switching to a zinc preparation offered the young woman some relief.

8.8

Reduced hives itching

Most Useful Review

I purchased zinc as it is easier to absorb alongside vitamin A supplements. After sweating heavily in hot yoga and fitness boxing, I dealt with chronic hives. Continuing to take zinc, I noticed the itching from hives decreased, my nails strengthened, and hair loss significantly reduced. I believe zinc was a missing ingredient for me, benefiting not just my appearance but also my overall health, like reducing the likelihood of catching a cold. I plan to continue taking it as the size is easy to swallow and does not irritate me.

Liver Disease

Zinc's Role in Liver Health

Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings.

Most Relevant Research

We focused on the connection between zinc and liver health, particularly how it may influence conditions like non-alcoholic fatty liver disease (NAFLD) and metabolic issues, including type II diabetes (T2D). Our analysis of data from a large genetics cohort revealed a significant finding: rare genetic variants that reduce the function of the zinc transporter SLC39A5 were linked to better metabolic profiles and lower T2D risk.

To delve deeper into these results, we used both laboratory and animal models. We developed mice that completely lacked SLC39A5 and observed promising outcomes. These mice showcased improved liver function and lower blood sugar levels after being subjected to obesity challenges, whether congenital or diet-induced.

Notably, this improvement seemed to be associated with increased levels of zinc in the liver, which activated key signaling pathways involved in metabolism, such as AMPK and AKT. Furthermore, these mice exhibited less liver inflammation and fibrosis in models of diet-induced non-alcoholic steatohepatitis (NASH).

Together, these findings position SLC39A5 as a potentially valuable target for treating liver-related metabolic disorders, emphasizing zinc's crucial role in managing liver health and blood sugar regulation.

Supports liver health

Most Useful Review

It is a chelate type and is expected to be well absorbed. A severe zinc deficiency can lead to serious liver disease. Zinc aids the liver's immune system to combat hostile microbes. I take one tablet every day.

Lung Cancer

Zinc's role in lung cancer treatment

Based on 4 Researches

The human zinc-binding cysteine proteome.

Most Relevant Research

We explored the role of zinc as an essential micronutrient that influences various physiological processes, particularly in the context of lung cancer. Our study focused on understanding how zinc binds to specific sites on proteins, especially cysteine residues, and how this binding affects cancer cell behavior.

Through a thorough mapping called ZnCPT, we identified a significant number of zinc-binding cysteines—6,173 in total. This mapping allowed us to uncover several protein families that are affected by zinc binding, either on a regular basis or when induced.

Importantly, we discovered that zinc could influence 52 genetic dependencies in cancer, pointing toward some malignancies that might be particularly sensitive to zinc's effects. In our findings, we observed a specific mechanism where zinc regulates the enzyme glutathione reductase (GSR). This regulation appears to drive cell death in certain lung cancers that rely on GSR, suggesting a potential avenue for future treatments.

Overall, while zinc shows promise in affecting lung cancer cells, further investigation will be essential to fully understand its therapeutic potential.

Helpful for lung cancer

Most Useful Review

I bought this for an elderly person with lung deficiency, phlegm, and a persistent cough. Zinc supplementation has proven beneficial.

Menopause

Zinc enhances vitamin D in menopause

Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial.

Most Relevant Research

We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.

Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.

Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.

Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.

7.5

Necessary for menopause

Most Useful Review

Convenient small capsules are essential for my mother during menopause. Many have touted their benefits. They are well tolerated, and I have observed no negative aspects.

Multiple Sclerosis

Zinc levels and MS correlation

Based on 3 Researches

Relationship between zinc-related nutritional status and the progression of multiple sclerosis.

Most Relevant Research

We conducted a study to understand how zinc may affect multiple sclerosis (MS). Our research involved 98 participants, divided into two groups: one with MS and another matched control group without the condition. We aimed to examine the levels of zinc in both plasma and red blood cells to see if there’s a connection with MS severity and outbreaks.

The findings were intriguing. We discovered that while the average plasma zinc levels were normal in MS patients, their red blood cell zinc levels were actually higher than those in the control group. Additionally, we noticed that the activity of an important enzyme called superoxide dismutase (SOD) was significantly elevated in MS patients, which correlates positively with these higher zinc levels. This suggests that while the body might be managing zinc rather well, it’s working overtime, possibly to counteract oxidative stress related to MS.

Importantly, we observed a direct correlation between erythrocyte zinc and SOD activity, which was also linked inversely to MS outbreaks—indicating that as SOD increases in activity, the frequency of outbreaks tends to decrease. These insights confirm that there could be a beneficial relationship between zinc levels and the management of MS, but more research is certainly needed to explore this further.

8.8

Positive effects noted

Most Useful Review

I use this medication as part of my treatment for multiple sclerosis, as prescribed by my doctor. It has a significant impact on my hair and nails, and I find myself craving fewer sweets.

Obesity

Zinc improves prostate health in obesity

Based on 9 Researches

Zinc Attenuates Prostate Hyperplasia and Inflammatory Injury in Obese Rats by Regulating Zinc Homeostasis and Inhibiting the JAK1/STAT3 Pathway.

Most Relevant Research

We explored how zinc supplementation affects prostate health in obese rats, particularly in terms of prostate inflammation and cell proliferation. The study involved a well-structured experiment with control and treatment groups over eight weeks. Obese rats were given either zinc sulfate or a saline solution, allowing us to compare the effects of zinc directly.

Our findings revealed that obese rats experienced reduced sperm health and increased inflammatory markers in prostate tissue. Upon zinc supplementation, these rats showed improved sperm motility and count, alongside a notable reduction in inflammatory cytokines and insulin growth factors.

We observed significant changes in the expression of zinc transporters, which regulate zinc levels in the body, after supplementation. The results also indicated that zinc negatively affected the JAK1/STAT3 signaling pathway, which is often linked to inflammation and cancer, suggesting a potential mechanism by which zinc supports prostate health.

Overall, our study presents compelling evidence that zinc can be an effective tool in managing obesity-related prostate issues, highlighting its role in promoting healthier reproductive function in males.

Reduced cravings

Most Useful Review

I noticed from my first visit that I no longer feel an uncontrollable urge to sweep everything off the table, which is a significant benefit. I have struggled with metabolic disorders, hypothyroidism, and obesity, and I hope that zinc will aid in maintaining my immunity during this second wave. I believe it can help!

Prostate Cancer

Zinc's complex role in prostate cancer

Prostate cancer-selective anticancer action of an oxindole derivative via HO-1-mediated disruption of metabolic reprogramming.

Most Relevant Research

We explored the relationship between zinc levels and prostate cancer treatments, particularly focusing on a novel compound known as 3D. This compound showed a strong potential to target prostate cancer cells, contributing to a decrease in their proliferation rates.

Our analysis revealed that compound 3D selectively impacted key metabolic processes in prostate cancer cells by suppressing factors related to energy production, such as lactate levels. Interestingly, it also reduced the activity of transporters involved in zinc absorption while leaving those responsible for zinc export untouched.

We also found that the effectiveness of 3D could be reversed with zinc treatment, highlighting a complicated interaction between zinc and this therapeutic approach. While the compound successfully lowered zinc levels in cells and inhibited cancer growth, it is essential to note that we did not find significant benefits from zinc treatment by itself in the context of this study.

Overall, our findings suggest that targeting zinc metabolism and enhancing heme oxygenase-1 expression could be a promising strategy in prostate cancer therapy, more so than the direct application of zinc itself. The results illustrate the potential for combining innovative small molecules with an understanding of cancer metabolism in the development of treatment strategies.

9.5

Pain relief

Most Useful Review

With chronic prostatitis, this supplement has become my top choice. I experience less pain and improved sperm quality, and zinc has increased my free testosterone levels. I highly recommend it to anyone dealing with issues related to prostate cancer.

Psoriasis

Zinc conditioner benefits scalp psoriasis

Based on 5 Researches

Efficacy and safety of supramolecular active zinc in the treatment of scalp psoriasis: a multicentre, randomized, observed-blind, parallel-group, placebo- and active-controlled noninferiority trial.

Most Relevant Research

We delved into the effectiveness of a zinc-based hair conditioner specifically designed for treating scalp psoriasis. This study was a well-structured clinical trial involving 211 participants, where individuals were divided into three groups: those receiving the specialized zinc treatment, a placebo, and a control group given calcipotriol ointment. Remarkably, the trial was multicenter and observed-blind, which adds credibility to the findings.

Our results revealed that the zinc conditioner led to a 39% disease control rate after four weeks, compared to 25% for the placebo and 37% for the calcipotriol ointment group. This means that the zinc treatment significantly outperformed the placebo while being on par with the active control variant. In essence, those using the zinc product experienced better management of their scalp psoriasis than those using a non-active alternative.

Overall, our findings highlight that a supramolecular active zinc antidandruff formulation is not just effective for treating scalp psoriasis but also helps in maintaining results over time and potentially preventing future flare-ups. This offers a promising new avenue for patients seeking relief from this chronic condition.

8.8

Boosts skin health

Most Useful Review

Excellent for preventing viral diseases and enhancing men's health, this supplement regulates blood sugar and aids conditions like acne, psoriasis, and eczema. It promotes the antioxidant glutathione and helps detoxify the body. The zinc is in a chelated form, making it easy to absorb without irritating the gut. I find it effective and highly recommend it.

Tinnitus

Zinc intake affects tinnitus risk

The Association between Dietary Intakes of Vitamins and Minerals with Tinnitus.

Most Relevant Research

We examined how dietary intakes of vitamins and minerals, particularly zinc, could influence the onset and presence of tinnitus, a condition characterized by phantom sounds in the ears. In a study involving nearly 3,000 participants over the age of 50, we identified cases of tinnitus to determine if their dietary habits played a role in their experience of this condition.

The findings indicated that while there were no significant associations between overall vitamin and mineral intake and existing tinnitus prevalence, zinc intake stood out in relation to developing tinnitus over time. Specifically, we observed that lower zinc consumption was linked to a 44% increased risk of experiencing tinnitus over a ten-year period.

Furthermore, we noted that iron intake also showed a significant correlation, with lower iron levels raising incident tinnitus risk by approximately 35%. These results highlight the potential importance of maintaining adequate zinc and iron levels in our diets to help reduce the risk of developing tinnitus.

8.8

Supports tinnitus treatment

Most Useful Review

I take it with vitamin B12 as it is beneficial for tinnitus.

Ulcer

New treatment reduces digital dermatitis

Based on 10 Researches

Investigation on the effectiveness of a new hoof care product to sustainably reduce and prevent digital dermatitis in dairy cow herds.

Most Relevant Research

We embarked on an investigation to understand whether a new hoof care product featuring iron, zinc, and aluminum can effectively reduce and prevent digital dermatitis (DD) in dairy cows. In a controlled trial involving over 130 dairy cows, we treated one hind foot of each cow twice a week with this product while leaving the other foot untreated for comparison.

The results were revealing! Our analysis indicated that the use of the hoof care product significantly reduced the severity of DD compared to the untreated group. In fact, cows treated with the product had a much lower chance of developing lesions. The outcome showed that in the control group, the odds of having a lesion were four times higher than in the treated group, and the likelihood of experiencing an active lesion versus an inactive one was even more pronounced.

Interestingly, we also observed positive outcomes in heifers, with only one developing an active lesion in the treated group, showcasing the potential for this product to help manage and prevent DD even before these young cows enter the herd. The study indicates that the combination of ingredients in this hoof care product could be a promising alternative to traditional, harsher treatments.

While zinc is included as one of the components in the product, it's essential to note that we can't isolate its effect on ulcers from the other ingredients. Therefore, we can't definitively conclude zinc's sole effectiveness when it comes to DD treatment, but the overall findings are encouraging for improving hoof health in dairy cows.

8.3

Reduced mouth ulcers

Most Useful Review

Let's take this for women! I no longer suffer from mouth ulcers that occurred before my period. However, if my diet isn’t good, I do feel uncomfortable at times.

Cancer

Zinc's role in cancer immunity

Based on 6 Researches

cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance.

Most Relevant Research

We explored how zinc levels impact cancer cells and immune function, particularly focusing on macrophages, which are crucial for our body’s defense against tumors. Our research revealed that cancer cells often have decreased expression of specific genes tied to immune response, and this links to resistance against therapies designed to unblock immune checkpoints.

By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.

Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.

Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.

8.8

Supports cancer treatment

Most Useful Review

I would recommend this zinc to all men! The quality is excellent, and the small capsules are easy to swallow without any unpleasant taste. A dosage of 30 mg is optimal for minor deficiencies. Zinc is crucial for immune health and has beneficial effects on hormonal balance and inflammation. A lack of zinc can lead to issues like frequent illness and poor healing. It is vital for various metabolic processes, and for better absorption, vitamins A and B6 are necessary.

Heart Attack

ZnO NPs protect heart health

Based on 9 Researches

In vivo cardioprotective effect of zinc oxide nanoparticles against doxorubicin-induced myocardial infarction by enhancing the antioxidant system and nitric oxide production.

Most Relevant Research

We aimed to explore how zinc oxide nanoparticles (ZnO NPs) could protect the heart from damage caused by doxorubicin, a drug that can lead to serious heart issues, including myocardial infarction (MI). Our study involved rats that were injected with doxorubicin to induce MI and then treated with ZnO NPs at two different doses.

Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.

Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.

7.5

Boosts immunity

Most Useful Review

Zinc is a very beneficial drug for heart health. It should be consumed regularly and is well absorbed by the body. The large packaging is a plus. It’s essential to have a test to assess zinc deficiency before starting the drug. It is also great for boosting immunity during winter.

Insomnia

Zinc promotes sleep in mice

Based on 3 Researches

Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice.

Most Relevant Research

We explored the effects of zinc on sleep by looking at how it might help with insomnia. In our study, we gave mice a zinc-containing yeast extract and monitored their behavior and brain activity. The results were quite promising.

We found that administering zinc at doses of 40 and 80 mg/kg led to a significant increase in non-rapid eye movement (NREM) sleep. This means that the mice were not only sleeping longer but also showed less activity, which is a good indicator of effective sleep. Interestingly, we did not observe any changes in rapid eye movement (REM) sleep, a crucial sleep phase for dreaming and deep rest.

Importantly, we didn’t see any negative side effects, such as rebound insomnia, within 24 hours after treating the mice. This suggests that zinc could be a safe option for those struggling with sleep issues, unlike other mineral extracts we tested, such as manganese, iron, and copper, which did not affect locomotor activity at all.

Overall, our findings provide the first evidence that zinc has a direct role in promoting sleep, opening up exciting possibilities for new sleep supplements featuring this essential mineral.

9.5

Improved sleep quality

Most Useful Review

I had insomnia, but since I started taking this, I began sleeping better and my skin feels smoother.

Anemia

Questionable

Zinc deficiency linked to anemia

Zinc Deficiency Presenting With Diverse Symptoms in a Young Patient: A Case Report.

Most Relevant Research

We explored the connection between zinc deficiency and anemia through the case of an 18-year-old woman who faced a series of health issues, including urinary tract infections and insulin dysfunction. After a thorough assessment, she was diagnosed with zinc deficiency, shedding light on how this overlooked issue can impact overall health.

What stood out to us was the rapid recovery the patient experienced after beginning oral zinc supplementation. Zinc plays a critical role in numerous bodily functions, including immune support and protein regulation. By addressing her deficiency, we observed significant improvement in her symptoms, including anemia.

The patient’s diet contained high levels of substances that were inhibiting her zinc absorption, which likely contributed to her condition. This case emphasizes the importance of recognizing zinc deficiency as a potential underlying cause for unexplained health issues, particularly anemia. Prompt diagnosis and treatment can lead to a complete turnaround in the patient's health.

By sharing this experience, we hope to raise awareness among clinicians about the vital role of zinc in managing anemia and encourage timely interventions for patients showing diverse symptoms.

8.8

Improved nails

Most Useful Review

Glycine makes the chelate easier to consume. I suffered from broken nails and hair loss due to anemia. Zinc is claimed to strengthen mucous membranes and is beneficial for the skin. My nails have improved since I started taking it. A friend who developed a taste disorder after his COVID-19 vaccine was cured after I gave him this. Many people may have a zinc deficiency, and I found glycine zinc to be easy to take!

Chest Pain

Zinc treatment for angina pectoris

High-dose zinc to terminate angina pectoris: a review and hypothesis for action by ICAM inhibition.

Most Relevant Research

We delved into an intriguing question: Can high doses of zinc help relieve chest pain caused by angina pectoris? Our research reviewed studies that highlight how zinc may play a role in managing this condition. Angina pectoris often results from arteriosclerosis, where the arteries become narrowed due to cholesterol buildup and other factors.

We discovered that patients with severe atherosclerosis showed promising improvements when treated with high-dose zinc. Specifically, a treatment regimen involved raising serum zinc levels significantly, resulting in symptom relief for many individuals. In one notable case, 12 out of 16 patients experienced measurable benefits, including one patient who also suffered from Raynaud's disease.

Furthermore, our analysis noted that long-term exposure to zinc in the environment correlated with reduced incidence of angina and ischemic events during exercise. Zinc appears to possess antioxidant properties, which may protect against the oxidation of LDL cholesterol, a key player in artery damage. By blocking certain inflammatory factors and promoting better circulation, zinc might enhance heart function and alleviate chest pain.

Based on these findings, we propose that zinc treatment should be considered a fundamental option in both prevention and therapy for atherosclerosis-related chest pain. This could lead to a renewed focus on restoring a healthier cardiac function among those affected by these conditions.

9.5

Pain relief

Most Useful Review

Excellent! My herpes vanished two days after taking it. It's a fantastic remedy for a man, and the pain in my urinary-genital system has disappeared.

Constipation

Zinc may mitigate granisetron constipation

Carbon monoxide contributes to the constipating effects of granisetron in rat colon.

Most Relevant Research

We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.

Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.

Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.

9.5

Resolved constipation

Most Useful Review

Since I started taking this, my constipation issue has significantly improved.

Allergies

Zinc may relieve allergy symptoms

Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.

Most Relevant Research

We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.

Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.

The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.

Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.

9.5

Reduced nasal allergies

Most Useful Review

I found zinc glycinate helpful for nasal allergies. It is easily absorbed and rarely causes side effects. Combined with optimized papillin, it has improved my allergic rhinitis and I no longer suffer from nasal issues.

Headache

Zinc reduces migraine symptoms

Based on 8 Researches

Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women.

Most Relevant Research

We conducted a randomized, double-blind, placebo-controlled trial to explore how zinc gluconate affects migraine symptoms in women. Sixty participants, with an average age of 35, were given either 15 mg of zinc per day or a placebo for 12 weeks, allowing us to measure the impact on headache frequency, duration, and intensity.

The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.

Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.

In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.

9.5

Relieves headaches

Most Useful Review

This zinc is fantastic. It effectively alleviates headaches, and when I sense a cold coming, I take a loading dose of three capsules daily for 3-4 days, then one capsule for a couple of days. Colds vanish, and the large tub is very economical.

Nausea

Zinc treatment reduces nausea risk

Questionable

Based on 4 Researches

Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia.

Most Relevant Research

We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.

For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.

Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.

9.5

No nausea noted

Most Useful Review

I ordered this for my grandmother, and everything is fine with no nausea or side effects. A reliable choice for her needs!

Food Poisoning

Zinc oxide combats foodborne pathogens

Based on 3 Researches

Active Packaging of Immobilized Zinc Oxide Nanoparticles Controls Campylobacter jejuni in Raw Chicken Meat.

Most Relevant Research

We set out to explore how zinc oxide nanoparticles (ZnO NPs) could help control the bacteria responsible for food poisoning in raw chicken meat. Our approach involved integrating these nanoparticles into packaging materials to see if they could effectively inactivate Campylobacter jejuni, a common and concerning pathogen in poultry.

Through our experiments, we discovered that immobilizing ZnO NPs in functional pads placed under raw chicken could dramatically reduce bacterial counts. In fact, we saw a reduction from about 4 log CFU to an undetectable level within just three days when storing chicken at 4°C. Notably, we monitored zinc levels in the chicken meat, confirming a safe release of zinc without any migration of nanoparticles onto the food. This means that we can help keep raw chicken safe and fresh without compromising its integrity or quality.

Not only did we find that these functional pads inactivated the harmful bacteria, but we also noted a related increase in lactic acid production, which plays a role in further protecting the meat. Our findings open up new avenues for using zinc in food packaging, offering a way to enhance food safety without directly adding chemicals to the food itself. Overall, this study highlights the potential for nanotechnology to play a significant role in managing foodborne pathogens like Campylobacter in poultry products.

2.5

No change

Most Useful Review

Food is enough for me. I tried using this supplement without seeing any change, so I have decided to stop. It appears I have not needed it to combat food poisoning.

Dizziness