NOW Supplements Zinc Glycinate

Back Pain details

Zinc may boost bone density

Based on 2 Researches

Bhardwaj A, Swe KMM, Sinha NK. Treatment for osteoporosis in people with beta-thalassaemia. Cochrane Database Syst Rev. 2023;5:CD010429. doi:10.1002/14651858.CD010429.pub3

We explored how zinc supplementation might help with back pain in individuals with beta-thalassaemia. The research included a randomized controlled trial with 42 participants, where some received zinc while others were given a placebo.

Results showed that zinc supplementation likely increased the bone mineral density (BMD) at the lumbar spine and hip after 12 to 18 months of treatment. This improvement in bone health could suggest potential benefits in pain relief, although the study didn’t directly measure back pain outcomes.

Even though the findings about BMD improvements are promising, we should be cautious. The trial didn't provide direct evidence on whether zinc specifically alleviates back pain. It’s essential to recognize that while we observed positive changes in bone density, interpreting this as a definitive solution for back pain would be premature.

Thus, further research is necessary to connect zinc's effects on bone health to actual pain relief in order to offer clearer guidance on its use as a treatment for back pain.

Reduced pain

Most Useful Review

13 people found this helpful

With chronic prostatitis, this is my go-to supplement. It has significantly reduced my pain and improved sperm quality, while zinc has increased my free testosterone levels. I highly recommend it to anyone suffering from chronic issues. Research shows that zinc levels in prostate secretion decrease with prostatitis, necessitating supplementation.

Updated: Apr 2025

Bloating details

Improved stomach condition

30 people found this helpful

After three months of taking one softgel on an empty stomach, I've noticed improvements in my facial skin and less oiliness in my skin and hair. My plasma zinc levels increased, and I will continue using this product. It’s a potent and cost-effective form of zinc with no stomach pain or bloating.

Erectile Dysfunction details

Zinc improves erectile dysfunction

Mahajan SK, Abbasi AA, Prasad AS, Rabbani P, Briggs WA, et al. Effect of oral zinc therapy on gonadal function in hemodialysis patients. A double-blind study. Ann Intern Med. 1982;97:357.

We observed the effects of zinc on erectile dysfunction in a carefully designed study that involved a double-blind trial. Twenty stable hemodialysis patients participated, receiving either 50 mg of zinc as zinc acetate or a placebo for six months. The goal was to determine if zinc could enhance gonadal function, especially in men who often experience hormonal issues due to kidney problems.

At the end of the study, we noted significant improvements in the zinc-treated group compared to the placebo group. Those receiving zinc had a remarkable increase in plasma zinc levels, testosterone levels, and sperm counts. Specifically, testosterone levels rose from 2.8 to 5.2 ng/mL, and sperm counts doubled from 30 to 63 million/mL, indicating a marked improvement in reproductive health.

Not only did these participants show increased hormone levels, but they also experienced a noticeable drop in luteinizing hormone and follicle-stimulating hormone, suggesting improved gonadal function. Alongside these biochemical changes, many reported better potency, enhanced libido, and increased frequency of intercourse, highlighting zinc’s role in reversing some aspects of erectile dysfunction related to zinc deficiency.

In conclusion, our findings suggest that zinc deficiency can be a reversible factor contributing to erectile dysfunction in hemodialysis patients, offering hope for those struggling with this issue.

Enhanced immunity

Most Useful Review

It’s nearly impossible to fully replace zinc deficiency through diet alone, but zinc is crucial for immunity, visual acuity, hair health, and preventing sexual dysfunctions. I've noticed significant improvement in my hair health. After injuring my finger, the wound healed remarkably well in just a few days. I take zinc combined with other vitamins and, while I can't pinpoint which one had the most effect, the results speak for themselves. I take a zinc complex for preventive health every six months.

Updated: Mar 2026

Insomnia details

Zinc promotes sleep in mice

Based on 3 Researches

Cherasse Y, Saito H, Nagata N, Aritake K, Lazarus M, et al. Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice. Mol Nutr Food Res. 2015;59:2087. doi:10.1002/mnfr.201500082

We explored the effects of zinc on sleep by looking at how it might help with insomnia. In our study, we gave mice a zinc-containing yeast extract and monitored their behavior and brain activity. The results were quite promising.

We found that administering zinc at doses of 40 and 80 mg/kg led to a significant increase in non-rapid eye movement (NREM) sleep. This means that the mice were not only sleeping longer but also showed less activity, which is a good indicator of effective sleep. Interestingly, we did not observe any changes in rapid eye movement (REM) sleep, a crucial sleep phase for dreaming and deep rest.

Importantly, we didn’t see any negative side effects, such as rebound insomnia, within 24 hours after treating the mice. This suggests that zinc could be a safe option for those struggling with sleep issues, unlike other mineral extracts we tested, such as manganese, iron, and copper, which did not affect locomotor activity at all.

Overall, our findings provide the first evidence that zinc has a direct role in promoting sleep, opening up exciting possibilities for new sleep supplements featuring this essential mineral.

Improved sleep quality

Most Useful Review

I had insomnia, but since I started taking this, I began sleeping better and my skin feels smoother.

Updated: Mar 2026

Migraine details

Zinc reduces migraine symptoms

Mazaheri M, Aghdam AM, Heidari M, Zarrin R. Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women. Clin Nutr Res. 2021;10:127. doi:10.7762/cnr.2021.10.2.127

This study was designed as a randomized double-blind, placebo-controlled trial to examine how zinc gluconate supplementation might alleviate migraine symptoms in adult women. We followed 60 women, averaging about 35 years old, who either received 15 mg of zinc per day or a placebo for a duration of 12 weeks.

Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.

Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.

Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.

Migraine relief

Most Useful Review

Great! It normalises sleep (with regular intake of 2 capsules) and improves my migraines. When special effects begin, I take the pills and add extra magnesium, which smoothens my migraine within a couple of hours. The frequency has also decreased, and magnesium helps alleviate PMS and menstruation. Chronic nasopharynx pain hardly worsens. While I’m taking omega-3 and other supplements, magnesium's role is significant. There were no allergies or stomach issues. The quality is excellent, with natural ingredients that have a beneficial influence on health.

Updated: Apr 2025

Pneumonia details

1 people found this helpful

My mother, aged 78, experienced colds and pneumonia previously. We started giving her Zinc Glycinate, and her health has significantly improved. She hasn’t had any colds, flu, or pneumonia since, and we are delighted with the results. I highly recommend Zinc from Now Foods.

Psoriasis details

Zinc conditioner benefits scalp psoriasis

Based on 5 Researches

Yu C, Yu N, Jiang X, Gao X, Lv S, et al. Efficacy and safety of supramolecular active zinc in the treatment of scalp psoriasis: a multicentre, randomized, observed-blind, parallel-group, placebo- and active-controlled noninferiority trial. Clin Exp Dermatol. 2023;48:1138. doi:10.1093/ced/llad168

We delved into the effectiveness of a zinc-based hair conditioner specifically designed for treating scalp psoriasis. This study was a well-structured clinical trial involving 211 participants, where individuals were divided into three groups: those receiving the specialized zinc treatment, a placebo, and a control group given calcipotriol ointment. Remarkably, the trial was multicenter and observed-blind, which adds credibility to the findings.

Our results revealed that the zinc conditioner led to a 39% disease control rate after four weeks, compared to 25% for the placebo and 37% for the calcipotriol ointment group. This means that the zinc treatment significantly outperformed the placebo while being on par with the active control variant. In essence, those using the zinc product experienced better management of their scalp psoriasis than those using a non-active alternative.

Overall, our findings highlight that a supramolecular active zinc antidandruff formulation is not just effective for treating scalp psoriasis but also helps in maintaining results over time and potentially preventing future flare-ups. This offers a promising new avenue for patients seeking relief from this chronic condition.

Reduces psoriasis symptoms

Most Useful Review

I’ve been using this for three years for my psoriasis. During flare-ups, I take one tablet daily for a few months, with a dosage of at least 50 mcg. This has significantly reduced itching, redness, and peeling, and I have even seen areas where spots have completely vanished.

Updated: Mar 2026

Weight Loss details

Improves metabolism and promotes weight loss.

Chronic Fatigue Syndrome details

Zinc supplementation may benefit CFS

Maes M, Mihaylova I, De Ruyter M. Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS. J Affect Disord. 2006;90:141.

We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.

Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.

Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.

Increased energy levels

Most Useful Review

91 people found this helpful

I had been suffering from chronic fatigue syndrome for months when I tried this amazing vitamin. Within a few days, I noticed a significant increase in my energy, allowing me to exercise without problems. This supplement is cost-effective and has greatly improved my quality of life.

Updated: Mar 2026

Diabetes details

Zinc alleviates diabetic muscle atrophy

Based on 2 Researches

Yu X, Chen X, Wu W, Tang H, Su Y, et al. Zinc Alleviates Diabetic Muscle Atrophy via Modulation of the SIRT1/FoxO1 Autophagy Pathway Through GPR39. J Cachexia Sarcopenia Muscle. 2025;16:e13771. doi:10.1002/jcsm.13771

Our investigation aimed to understand how zinc affects muscle atrophy in diabetes, a serious complication that leads to muscle loss. Using diabetes-induced mice, we treated them with zinc sulfate for six weeks and observed notable improvements in their muscle condition.

We conducted various analyses to evaluate the impact of zinc on autophagy—the process that helps manage muscle mass. The results were promising; zinc appeared to enhance muscle recovery by regulating specific molecular pathways connected to muscle health.

Additionally, our in vitro studies with diabetic muscle cells revealed similar results, with zinc supplementation proving beneficial in reducing excessive autophagy. Overall, this suggests that incorporating zinc into treatment plans could be a promising approach to counteract muscle deterioration in diabetic patients.

Normalises blood sugar

Most Useful Review

Zinc glycinate is a highly bioavailable form of zinc, easily absorbed by the body. It plays a vital role in metabolism, hormone production, and maintaining heart health. I purchased this complex as it is essential for my health, especially as it effectively normalises blood glucose levels, thereby preventing the onset of diabetes. I trust that you will find this review useful!

Updated: Mar 2026

Hashimoto details

Zinc's link to Hashimoto's thyroiditis

Based on 2 Researches

Rostami R, Beiranvand A, Nourooz-Zadeh S, Rostami M, Mohammadi A, et al. Association Between Essential Trace Elements and Thyroid Antibodies in the Blood of Women with Newly Diagnosed Hashimoto's Thyroiditis. Int J Endocrinol Metab. 2024;22:e145599. doi:10.5812/ijem-145599

We explored the connection between essential trace elements, particularly zinc, and Hashimoto’s thyroiditis (HT) in women who were newly diagnosed. In this study, we looked at a group of 56 women with HT and compared them to 64 matched controls.

The results showed that women with HT had significantly lower levels of selenium, iron, and zinc in their blood compared to the controls. Interestingly, their copper levels were higher. We examined the relationships between these trace elements and thyroid autoantibodies, which can indicate the presence of autoimmune activity affecting the thyroid.

While we noted a significant correlation between lower zinc (and other elements) and higher levels of thyroid antibodies, the study did not specifically focus on zinc treatment. This means that while zinc levels appear to be linked to autoantibody levels in HT, we can't definitively state that zinc treatment will improve the condition without further dedicated research.

Overall, the study indicates that lower zinc levels in conjunction with selenium and iron deficiencies might be involved in the autoimmune response seen in Hashimoto’s thyroiditis. Thus, this provides an avenue for future exploration into zinc's role as a potential supplement for women diagnosed with this condition.

Must-have supplement

Most Useful Review

Excellent quality! This is a must-have for anyone with Hashimoto's disease, as it contains safe ingredients.

Updated: Mar 2026

Polycystic Ovary Syndrome details

Cycle regularity achieved

My cycle has become regular, and Polycystic ovary syndrome no longer troubles me. Zinc has been beneficial for my condition.

Cold Sores details

Zinc cream alleviates cold sores

Based on 9 Researches

Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med. 2001;7:49.

We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.

Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.

As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.

Helps with colds

Most Useful Review

102 people found this helpful

At the first signs of a cold, this product helps significantly; I recover in 4-5 days with vitamin C and D3.

Updated: Apr 2025

Heartburn details

Zinc's role in heartburn relief

Hayashi A, Taki Y, Arai K, Sato S, Higashizono K, et al. Esophageal ulcer related to zinc deficiency following a total gastrectomy. Nutrition. 2023;110:111999. doi:10.1016/j.nut.2023.111999

We investigated how zinc affects heartburn through the case of a 76-year-old Japanese man who experienced significant discomfort after undergoing a total gastrectomy. For two weeks, he suffered from a sore throat, heartburn, and difficulty swallowing. Endoscopy revealed deep, craterlike ulcers in his esophagus, but tests for viral infections were negative.

After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.

Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.

Heartburn improvement

Most Useful Review

3 people found this helpful

Easy to take with a soft gel. As a man in my 40s, I take 1 tablet daily after meals. If I experience heartburn, I take it with a vitamin C capsule, which helps improve my energy. I noticed my erections became firmer after taking it.

Updated: Mar 2026

Herpes details

Zinc sulfate effectively inhibits HSV

Based on 8 Researches

Fani M, Khodadad N, Ebrahimi S, Nahidsamiei R, Makvandi M, et al. Zinc Sulfate in Narrow Range as an In Vitro Anti-HSV-1 Assay. Biol Trace Elem Res. 2020;193:410. doi:10.1007/s12011-019-01728-0

We explored the antiviral effects of zinc sulfate on herpes simplex virus in Vero cells. Through a combination of traditional cell culture and advanced PCR methods, we found that a concentration of 0.3 mM zinc sulfate significantly reduced virus replication by at least 68 times. Moreover, we identified that the most effective concentration was actually 0.23 mM.

These findings suggest that zinc sulfate can inhibit herpes simplex virus, showing promise as a potential treatment option.

7.5

Boosts herpes treatment

Most Useful Review

8 people found this helpful

Zinc is crucial in combating herpes and papilloma viruses, enhancing the effectiveness of natural antiviral extracts like cat's claw and grapefruit. It also supports prostate health, reduces inflammation, and is vital for the regeneration of nerve cells affected by the herpes virus. Zinc plays a role in protein synthesis and connective tissue formation, improving skin and nails while reducing sweetness cravings. This supplement has greatly benefited my overall health.

Updated: Mar 2026

Hypothyroidism details

Zinc's uncertain role in hypothyroidism

Nikkhah M, Vafa M, Abiri B, Golgiri F, Sarbakhsh P, et al. The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial. Med J Islam Repub Iran. 2024;38:133. doi:10.47176/mjiri.38.133

We conducted a study to investigate the effects of micronutrient supplementation, including zinc, on thyroid function and overall quality of life in patients with hypothyroidism. Our trial involved 104 participants who were receiving levothyroxine and vitamin D. They were randomly assigned to either a group that received a mix of essential nutrients or a placebo group over eight weeks.

We measured various health markers before and after this period, including thyroid hormone levels, cholesterol, insulin resistance, and blood pressure. Our findings suggested that the group receiving the micronutrient supplement experienced improvements in insulin resistance and overall quality of life. However, it’s important to note that the specific effects of zinc alone are somewhat difficult to isolate, as it was part of a combination of nutrients being tested.

Ultimately, while the study indicates potential benefits of micronutrient supplementation for thyroid function in hypothyroid patients, further trials are necessary to clearly define the role of zinc and other nutrients in this context.

Health improvement

Most Useful Review

After three months of taking this zinc for my hypothyroidism, my condition has improved. I will continue using it alongside other vitamins and minerals. Zinc is crucial for numerous bodily functions.

Updated: Apr 2026

Knee Pain details

This zinc supplement works well. It is absorbed without causing abdominal pain and has led to an overall improvement in my health, definitely helping with knee pain.

Updated: Mar 2026

Osteoporosis details

Zinc intake may protect bones

Based on 10 Researches

Fang D, Jiang D, Shi G, Song Y. The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis. BMC Musculoskelet Disord. 2024;25:710. doi:10.1186/s12891-024-07768-5

We investigated the connection between dietary zinc intake and the prevalence of osteoporosis and osteopenia in patients with rheumatoid arthritis (RA). Using data from the National Health and Nutrition Examination Survey collected over several years, we applied various statistical methods to analyze how zinc impacts bone health in these patients.

Our findings revealed that higher dietary zinc intake appears to be linked with a lower incidence of osteopenia and osteoporosis among individuals with RA. This suggests that consuming adequate amounts of zinc might support better bone health for those suffering from this chronic condition.

Despite our positive findings, we acknowledge that further research, including longitudinal and randomized trials, is essential for confirming these results and understanding the underlying mechanisms at play. However, the evidence from our analysis encourages a focus on dietary zinc as a possible factor in maintaining bone health for patients with RA.

Helpful for osteoporosis

Most Useful Review

With advanced osteoporosis, this supplement effectively meets my needs, just as I expect from the "Now" brand.

Updated: Mar 2026

Rash details

Significantly decreased rashes

158 people found this helpful

Excellent zinc form that is easily absorbed! I take it alongside vitamin D and Omega 3. After starting this regimen, the rashes on my face diminished greatly, much to my dermatologist's approval. I did experience slight nausea during the first week, but that soon passed. Just be cautious and avoid combining it with copper within six hours.

Sore Throat details

Zinc reduces postoperative sore throat

Based on 9 Researches

Sarkar T, Mandal T. Preoperative oral zinc tablet decreases incidence of postoperative sore throat. Indian J Anaesth. 2020;64:409. doi:10.4103/ija.IJA_959_19

We investigated the impact of dispersible zinc tablets on postoperative sore throat (POST) experienced by patients after endotracheal intubation. In our study, 88 patients were divided into two groups. One group received a 40 mg zinc tablet, while the other received a placebo 30 minutes before their surgery.

Our findings revealed that the zinc group reported significantly fewer instances of POST at the 4-hour mark compared to the placebo group. Specifically, only 6.8% of patients in the zinc group experienced POST, while a higher 31.8% in the placebo group did. Furthermore, none of the patients taking zinc reported severe sore throat, a stark contrast to three patients in the placebo group who did.

Additionally, we noted lower severity ratings for sore throat in the zinc group at various time intervals post-surgery. The results emphasize that taking zinc tablets before surgery can effectively mitigate the incidence and discomfort of sore throat following intubation, presenting a simple solution for a common postoperative issue.

Prevents illness

Most Useful Review

At the first signs of a cold or sore throat, I combine it with vitamin C from ESTER-C. It prevents me from getting sick, and after a few days, I feel fantastic.

Updated: Apr 2025

Whooping Cough details

11 people found this helpful

I strongly recommend this product, especially for mothers with children. As soon as my child began to snot, I immediately gave him zinc in the morning and it vanished. I had a cough myself, started on zinc, and it disappeared like magic. It’s a fantastic product!

Anemia details

Questionable

Zinc deficiency linked to anemia

Inoue M. Zinc Deficiency Presenting With Diverse Symptoms in a Young Patient: A Case Report. Cureus. 2024;16:e66034. doi:10.7759/cureus.66034

We explored the connection between zinc deficiency and anemia through the case of an 18-year-old woman who faced a series of health issues, including urinary tract infections and insulin dysfunction. After a thorough assessment, she was diagnosed with zinc deficiency, shedding light on how this overlooked issue can impact overall health.

What stood out to us was the rapid recovery the patient experienced after beginning oral zinc supplementation. Zinc plays a critical role in numerous bodily functions, including immune support and protein regulation. By addressing her deficiency, we observed significant improvement in her symptoms, including anemia.

The patient’s diet contained high levels of substances that were inhibiting her zinc absorption, which likely contributed to her condition. This case emphasizes the importance of recognizing zinc deficiency as a potential underlying cause for unexplained health issues, particularly anemia. Prompt diagnosis and treatment can lead to a complete turnaround in the patient's health.

By sharing this experience, we hope to raise awareness among clinicians about the vital role of zinc in managing anemia and encourage timely interventions for patients showing diverse symptoms.

7.5

Absorption aid

Most Useful Review

Zinc acts as a cofactor for iron absorption. If you have anemia, this is essential. The product is well-formed and properly dosed, but always take it with food, not on an empty stomach, for best results.

Updated: Mar 2026

Anxiety details

Zinc may alleviate anxiety symptoms

Based on 8 Researches

Azargoonjahromi A. A systematic review of the association between zinc and anxiety. Nutr Rev. 2024;82:612. doi:10.1093/nutrit/nuad076

We explored the connection between zinc intake and anxiety in adults through a systematic review of nine original studies. Two of these studies looked at how zinc consumption impacts anxiety, while the other seven focused on the relationship between serum zinc levels and anxiety symptoms. Our analysis included studies published in English within peer-reviewed journals, ensuring a solid foundation for understanding this potential link.

What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.

In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.

7.5

Key to sleep

Most Useful Review

Zinc glycinate is my go-to for restful sleep, especially when anxiety disrupts my rest, such as before exams. It’s easily digestible and helps me manage stress effectively.

Updated: Mar 2026

Autoimmune Disorder details

Zinc supplementation benefits MS models

Bayiroglu AF, Acar G, Gulbahce-Mutlu E, Baltaci SB, Mogulkoc R, et al. Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model. J Trace Elem Med Biol. 2024;86:127540. doi:10.1016/j.jtemb.2024.127540

We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.

Quick recovery

Most Useful Review

6 people found this helpful

I ordered this zinc based on nutritionists' recommendations for speedy recovery from illness. When my husband lost his sense of smell due to illness, I started giving him zinc and vitamin C. Within five days, his smell returned, and he recovered quickly. This form of zinc is well absorbed and worth considering.

Updated: Mar 2026

Bone Pain details

1 people found this helpful

Excellent zinc supplement, vital for both adults and children. A deficiency can lead to developmental issues in youth. It plays a crucial role in metabolism, strengthens immunity, and has strong antioxidant qualities. My own experience with zinc has shown improvement in treating bone pain alongside supporting overall health.

Heart Disease details

Zinc benefits heart health post-cisplatin

Based on 4 Researches

Al-Lbban AM. Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats. Braz J Biol. 2025;84:e287764. doi:10.1590/1519-6984.287764

We explored the potential benefits of zinc oxide nanoparticles (ZnONPs) in preventing heart damage caused by cisplatin, a powerful chemotherapy drug known for its efficacy but also for its side effects, particularly cardiotoxicity.

In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.

As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.

Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.

7.5

Helps heart function

Most Useful Review

2 people found this helpful

Gift for a man for the New Year. We took this zinc when other options were unavailable and based on positive reviews. It helps! My husband's heart sometimes malfunctions, causing night awakenings, and dry skin is a burden. This zinc glycinate with pumpkin seed oil is great (alongside Vitamin D3). My husband is quite pleased!

Updated: Mar 2026

Menopause details

Zinc enhances vitamin D in menopause

Vázquez-Lorente H, Molina-López J, Herrera-Quintana L, Gamarra-Morales Y, López-González B, et al. Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial. J Trace Elem Med Biol. 2021;65:126730. doi:10.1016/j.jtemb.2021.126730

We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.

Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.

Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.

Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.

Mood improvement

Most Useful Review

I feel more mobile in the mornings, and my mood swings have calmed significantly.

Updated: Mar 2026

Blood Clot details

Zinc enhances blood clot formation

M S M, Samal DB, Amirtraj J V, Subramanian S, Venkatasubbu GD. Enhanced coagulation cascade activation and styptic effects of Zn@SiO nanocomposite. Colloids Surf B Biointerfaces. 2024;239:113927. doi:10.1016/j.colsurfb.2024.113927

We explored how zinc affects blood clotting, particularly through a substance called Zn@SiO nanocomposite. This material shows promise as a hemostatic agent, which means it helps stop bleeding by promoting the formation of stable blood clots.

During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.

Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.

This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.

Resolved deficiency

Most Useful Review

3 people found this helpful

I constantly have zinc deficiency in my blood tests, but since my nutritionist prescribed this supplement, the deficiency has improved without side effects like digestive discomfort. I’ve tried other brands unsuccessfully and always keep this one in stock.

Updated: Mar 2026

Cancer details

Zinc's role in cancer immunity

Buj R, Cole AR, Danielson J, Xu J, Hurd D, et al. cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance. bioRxiv. 2025. doi:10.1101/2025.02.08.637227

We explored how zinc levels impact cancer cells and immune function, particularly focusing on macrophages, which are crucial for our body’s defense against tumors. Our research revealed that cancer cells often have decreased expression of specific genes tied to immune response, and this links to resistance against therapies designed to unblock immune checkpoints.

By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.

Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.

Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.

7.5

Supports cancer treatment

Most Useful Review

I would recommend this zinc to all men! The quality is excellent, and the small capsules are easy to swallow without any unpleasant taste. A dosage of 30 mg is optimal for minor deficiencies. Zinc is crucial for immune health and has beneficial effects on hormonal balance and inflammation. A lack of zinc can lead to issues like frequent illness and poor healing. It is vital for various metabolic processes, and for better absorption, vitamins A and B6 are necessary.

Updated: Apr 2025

Flu details

Zinc treatment impacts flu virus entry

Nishi K, Yoshimoto S, Nishi S, Nishi T, Nishi R, et al. Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry. In Vivo. 2022;36:2357. doi:10.21873/invivo.12967

In our study, we examined how epipharyngeal abrasive therapy (EAT), which includes the use of zinc chloride, affects the expression of a key molecule known as Cav1.2. This molecule is essential for the influenza virus to enter cells, making it a crucial target in flu prevention strategies.

We compared two groups of patients: those who received EAT and those who did not. Our findings revealed that the levels of Cav1.2 were significantly lower in the EAT group, at a striking 4.19 times less than in the non-treated group. This suggests that the squamous metaplasia induced by EAT—which is a process of changing the epithelium—could be a beneficial approach to limiting flu infections.

The results of the study highlight zinc's potential indirect role in flu prevention by remarking on its contribution to lowering the expression of a critical receptor for the virus. Although we didn't isolate the effects of zinc alone, the findings indicate that treatments involving zinc, like EAT, may offer a straightforward way to help limit the impact of influenza.

Best for colds

Most Useful Review

25 people found this helpful

I find zinc glycinate to be the best during colds and flu. Our entire family takes it when we have colds. The quality is superb, with the most natural vitamins and ingredients.

Updated: Mar 2026

Indigestion details

Zinc-enhanced therapy improves eradication

Ibrahim N, El Said H, Choukair A. Zinc carnosine-based modified bismuth quadruple therapy standard triple therapy for eradication: A randomized controlled study. World J Clin Cases. 2022;10:227. doi:10.12998/wjcc.v10.i1.227

We explored the effectiveness of a modified bismuth quadruple therapy that includes zinc carnosine, in comparison to the traditional triple therapy for treating indigestion caused by Helicobacter pylori infection. In our study, 92 patients with symptoms of dyspepsia and positive breath tests were randomly assigned to receive either the conventional treatment of esomeprazole, amoxicillin, and clarithromycin for 14 days, or a shorter 10-day course of the new therapy that also included bismuth subcitrate and zinc carnosine.

The results were quite revealing. Our findings showed that the modified bismuth quadruple therapy group had a significantly higher eradication rate of 93.5%, compared to 69.6% in the standard treatment group. This suggests that the addition of zinc carnosine to the treatment regimen could enhance the effectiveness of indigestion relief. Importantly, the side effects reported between the two groups were similar, with only mild dizziness noted in those receiving the new therapy.

Overall, the study indicates that a shorter course of therapy that includes zinc carnosine may be a superior option for individuals suffering from indigestion related to Helicobacter pylori. This approach not only appears to work better but also does not lead to more serious side effects, making it an appealing alternative to traditional treatment methods.

No stomach issues

Most Useful Review

2 people found this helpful

I have experienced no stomach problems! Other forms of zinc, such as zinc gluconate, always caused me stomach issues after a few days. Finally, I discovered a zinc form that I can absorb without suffering from indigestion. It’s excellent!

Updated: Apr 2025

Leg Cramps details

This product has been effective. My leg cramps disappeared after I started taking zinc.

Updated: Apr 2026

Prostate Cancer details

Zinc's complex role in prostate cancer

Ghimire K, Awasthi BP, Yadav K, Lee J, Kim H, et al. Prostate cancer-selective anticancer action of an oxindole derivative via HO-1-mediated disruption of metabolic reprogramming. Chem Biol Interact. 2025;408:111393. doi:10.1016/j.cbi.2025.111393

We explored the relationship between zinc levels and prostate cancer treatments, particularly focusing on a novel compound known as 3D. This compound showed a strong potential to target prostate cancer cells, contributing to a decrease in their proliferation rates.

Our analysis revealed that compound 3D selectively impacted key metabolic processes in prostate cancer cells by suppressing factors related to energy production, such as lactate levels. Interestingly, it also reduced the activity of transporters involved in zinc absorption while leaving those responsible for zinc export untouched.

We also found that the effectiveness of 3D could be reversed with zinc treatment, highlighting a complicated interaction between zinc and this therapeutic approach. While the compound successfully lowered zinc levels in cells and inhibited cancer growth, it is essential to note that we did not find significant benefits from zinc treatment by itself in the context of this study.

Overall, our findings suggest that targeting zinc metabolism and enhancing heme oxygenase-1 expression could be a promising strategy in prostate cancer therapy, more so than the direct application of zinc itself. The results illustrate the potential for combining innovative small molecules with an understanding of cancer metabolism in the development of treatment strategies.

Pain relief

Most Useful Review

13 people found this helpful

With chronic prostatitis, this supplement has become my top choice. I experience less pain and improved sperm quality, and zinc has increased my free testosterone levels. I highly recommend it to anyone dealing with issues related to prostate cancer.

Updated: Mar 2026

Chest Pain details

Zinc treatment for angina pectoris

Eby GA, Halcomb WW. High-dose zinc to terminate angina pectoris: a review and hypothesis for action by ICAM inhibition. Med Hypotheses. 2006;66:169.

We delved into an intriguing question: Can high doses of zinc help relieve chest pain caused by angina pectoris? Our research reviewed studies that highlight how zinc may play a role in managing this condition. Angina pectoris often results from arteriosclerosis, where the arteries become narrowed due to cholesterol buildup and other factors.

We discovered that patients with severe atherosclerosis showed promising improvements when treated with high-dose zinc. Specifically, a treatment regimen involved raising serum zinc levels significantly, resulting in symptom relief for many individuals. In one notable case, 12 out of 16 patients experienced measurable benefits, including one patient who also suffered from Raynaud's disease.

Furthermore, our analysis noted that long-term exposure to zinc in the environment correlated with reduced incidence of angina and ischemic events during exercise. Zinc appears to possess antioxidant properties, which may protect against the oxidation of LDL cholesterol, a key player in artery damage. By blocking certain inflammatory factors and promoting better circulation, zinc might enhance heart function and alleviate chest pain.

Based on these findings, we propose that zinc treatment should be considered a fundamental option in both prevention and therapy for atherosclerosis-related chest pain. This could lead to a renewed focus on restoring a healthier cardiac function among those affected by these conditions.

Pain relief

Most Useful Review

1 people found this helpful

Excellent! My herpes vanished two days after taking it. It's a fantastic remedy for a man, and the pain in my urinary-genital system has disappeared.

Updated: Apr 2025

Chronic Cough details

Zinc acetate ineffective for chronic cough treatment

Very Likely Ineffective

Researchers tested whether zinc acetate could help people suffering from persistent, hard-to-treat cough. In this randomized, placebo-controlled pilot study, 34 participants received either zinc acetate or placebo for 6 weeks, with improvements measured using four different cough and quality-of-life scales.

While zinc successfully increased serum zinc levels in treated participants, both groups improved similarly across all measures. The improvements in cough symptoms and quality of life were too small to meet clinically meaningful thresholds, suggesting zinc acetate offers no real advantage over placebo for chronic cough sufferers.

7.5

Reduced symptoms

Most Useful Review

92 people found this helpful

I've been taking this vitamin for a while, and I’m pleased to say I haven't been as ill. The information I found indicated it’s excellent for colds and flu. My chronic cough has lessened, and my appetite has improved.

Updated: Apr 2026

Premenstrual Syndrome details

Less painful menstruation

This is the best dietary supplement in terms of price and zinc content, and my skin has certainly benefitted! I received it a few days ago, and I was surprised by the results! The scalp and face have become less oily within just 3 days. A couple of spots that appeared during premenstrual syndrome disappeared, and my menstruation was less painful this time. The tablets are of medium size, making them easy to swallow, with no side effects observed. Based on the results so far, I am confident that this course will greatly benefit me.

Updated: Apr 2026

Sleep Apnea details

Zinc protects heart function in OSA

Chen TI, Chen MY. Zinc Is Indispensable in Exercise-Induced Cardioprotection against Intermittent Hypoxia-Induced Left Ventricular Function Impairment in Rats. PLoS One. 2016;11:e0168600. doi:10.1371/journal.pone.0168600

We explored how zinc affects heart function in the context of obstructive sleep apnea (OSA), specifically focusing on cases of intermittent hypoxia (IH). In a detailed study using male rats, researchers set up different groups: a control group and one that underwent 10 weeks of exercise training. Half of the rats in both groups were exposed to IH conditions to simulate the effects of sleep apnea.

The results were eye-opening. Rats that experienced IH showed notable impairment in their heart's left ventricular function, characterized by reduced ejection fraction and increased inflammation. However, when treated with zinc, these negative effects were significantly countered. Notably, those who exercised and received zinc treatment displayed improved heart function and antioxidant capabilities compared to their counterparts that did not receive zinc.

On the flip side, exercise alone did not provide the same protective benefits when zinc was absent. The findings suggest that zinc is essential not only for the heart's protection against the damaging effects of IH but also enhances the benefits of physical exercise. This research indicates the importance of zinc in potentially managing heart health in individuals suffering from sleep apnea.

Quality sleep support

Most Useful Review

1 people found this helpful

I take this zinc before bed alongside magnesium, and it helps me sleep well and recover effectively.

Updated: Mar 2026

Cold details

Zinc’s effects on colds

Based on 3 Researches

Wieland LS. Zinc for prevention and treatment of the common cold: Summary of a Cochrane review. Explore (NY). 2025;21:103111. doi:10.1016/j.explore.2025.103111

We explored how zinc might help in treating and preventing the common cold. The study focused on zinc's effects, isolating it from other treatments to understand its true impact on cold symptoms. By doing this, the researchers aimed to clarify whether zinc could genuinely shorten the duration of a cold or alleviate its symptoms.

The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.

This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.

Effective for early relief

Most Useful Review

102 people found this helpful

At the first signs of a cold, this helps immensely; I usually recover in 4-5 days when combined with vitamin C and D3.

Updated: Apr 2025

Hair Loss details

Zinc shows promise for hair loss

Based on 9 Researches

Matsuoka N, Mizutani T, Kawakami K. Symptom Profile of Patients With Post-COVID-19 Conditions and Influencing Factors for Recovery. J Clin Med Res. 2023;15:116. doi:10.14740/jocmr4855

We explored how zinc acetate hydrate impacts hair loss for patients experiencing symptoms after COVID-19. In our analysis, we looked at 120 symptomatic outpatients over 12 weeks, observing their recovery patterns and any improvements in their symptoms. The focus was on various lingering effects, including fatigue and hair loss, particularly how zinc could potentially alleviate these issues.

Our findings highlighted significant improvements in hair loss for those treated with zinc acetate hydrate at multiple checkpoints (4, 8, and 12 weeks) compared to those who did not receive this treatment. The results were statistically significant and suggested that zinc could be a useful option for those struggling with hair loss post-COVID-19.

Additionally, we noted improvements in fatigue among those receiving zinc, although this was not as pronounced at all time intervals. As a whole, our study emphasized zinc's beneficial effects, particularly for hair loss, providing promising insights for anyone dealing with these challenging post-viral symptoms.

7.5

Reduced hair loss

Most Useful Review

37 people found this helpful

I started taking this supplement due to my hair loss, and testing revealed low zinc levels in my blood. Following my doctor's advice, I began taking it and noticed a reduction in hair loss.

Updated: Apr 2025

High Cholesterol details

Zinc improves cholesterol levels

Based on 5 Researches

Khajeh M, Hassanizadeh S, Pourteymour Fard Tabrizi F, Hassanizadeh R, Vajdi M, et al. Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis. Biol Trace Elem Res. 2024;202:4877. doi:10.1007/s12011-024-04059-x

We explored how zinc supplementation affects cholesterol levels and body composition in patients with type 2 diabetes. By reviewing data from nineteen randomized controlled trials, involving 1,357 participants, we uncovered significant findings regarding lipid profiles.

Our results revealed that zinc supplementation leads to reduced levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). Specifically, we noted reductions of 17.41 mg/dL in triglycerides, 19.60 mg/dL in total cholesterol, and 8.80 mg/dL in LDL-C. Furthermore, we observed an increase in high-density lipoprotein cholesterol (HDL-C) by 4.82 mg/dL, which is often termed "good" cholesterol.

While zinc appears to positively influence cholesterol levels, it's interesting to note that it did not have a significant impact on body weight. The body mass index (BMI) did show a slight decrease of 0.53 kg/m², but overall body weight remained unchanged.

In conclusion, our findings suggest that zinc supplementation could be a beneficial strategy for improving cholesterol levels in individuals with type 2 diabetes, thus contributing positively to their overall health and well-being.

7.5

Enhanced immune system

Most Useful Review

1 people found this helpful

ZinC is a marvellous dietary supplement that boosts my immune system. Since incorporating ZinC into my daily routine, I've noticed a marked improvement in my overall health. It aids in maintaining healthy skin, supports wound healing, and promotes the proper functioning of my immune system. I highly recommend ZinC for anyone seeking to enhance their immune response and maintain optimum health.

Updated: Mar 2026

Low Libido details

Libido and health benefits

Zinc is a crucial mineral involved in numerous bodily functions: it regulates essential hormones like testosterone and oestrogen, increases libido, helps with conception, and improves sleep quality. It also supports immunity, regulates mood, enhances skin quality, and aids in hair growth. Be warned: an overdose can lead to toxicity, so dosage should be determined via a blood test.

Common Cold details

Zinc shortens cold duration variability

Hemilä H, Chalker E, Tukiainen J. Quantile Treatment Effect of Zinc Lozenges on Common Cold Duration: A Novel Approach to Analyze the Effect of Treatment on Illness Duration. Front Pharmacol. 2022;13:817522. doi:10.3389/fphar.2022.817522

We explored how zinc lozenges affect the duration of the common cold through a detailed analysis of multiple trials. In particular, we focused on the Mossad (1996) trial involving zinc gluconate lozenges, which revealed an average reduction of cold duration by about 4.0 days. While that sounds promising, our findings through a quantile treatment effect (QTE) analysis tell a more nuanced story.

Interestingly, the QTE analysis showed that for individuals suffering from lengthy colds lasting 15 to 17 days, the zinc lozenges could shorten their illness by as much as 8 days. On the flip side, those with shorter, 2-day colds only experienced a 1-day reduction in sickness. This suggests that while zinc may help, its effectiveness varies significantly depending on the initial duration of the cold, making the overall average effect less informative than we might think.

Our examination extended to three trials that used zinc acetate lozenges, yielding a similar average reduction of around 2.7 days. However, again, those averages concealed varying effects for short and long colds, highlighting the importance of looking beyond simple averages in treatment studies.

Overall, we observed that zinc lozenges can indeed help with cold duration, but the extent of that help is very much dependent on how long a person has been suffering. This approach to understanding treatment effects through QTE analysis could have important implications not just for cold treatment but also for analyzing other health outcomes.

Enhances skin health

Most Useful Review

This product has greatly improved my skin! The size is ideal, and the effect on my skin has been remarkable—no more pimples since I started. The quality is super, and the taste is not bothersome.

Updated: Mar 2026

Blurred Vision details

Essential for eyesight

52 people found this helpful

Perfect!! Zinc deficiency can cause hair loss, dry hair, diminished ability to taste, delayed wound healing, attention deficits, blurred vision and cataracts, as well as weakened immunity. The more digestible forms include zinc glycinate and picolinate. Surprisingly, zinc significantly contributes to eye health by facilitating the transfer of vitamin A from the liver to the retina and forming melanin, a protective eye pigment. Research suggests that age-related visual impairment may be linked to long-term zinc deficiency. I'm glad if my review was helpful!

Diarrhea details

Zinc oxide mitigates diarrhea impacts

Zhang Y, Liu J, Li M, Dong Y, Li Z, et al. Zinc Oxide Administration Relieves the Diarrhea of ETEC K88-Infected Piglets by Reducing Ileal Apoptosis and Maintaining Gut Microbial Balance. Vet Sci. 2025;12. doi:10.3390/vetsci12020115

We explored how zinc oxide (ZnO), often used as a feed additive, affects diarrhea and gut health in piglets infected with the ETEC K88 strain. Through careful observation, we found that piglets suffering from this infection exhibited significantly increased fecal scores compared to those not affected. The ETEC K88 strain harms the small intestine, leading to a loss of villus height and a decrease in important antioxidant activities.

Our findings revealed that ZnO administration counteracts these negative effects effectively. It not only improved the overall health of the intestine but also enhanced its ability to combat oxidative stress. We also observed a balanced restoration of gut microbiota, as ZnO helped normalize the populations of certain beneficial bacteria altered by the infection.

In summary, our study indicates that ZnO can play a vital role in easing diarrhea in piglets infected with ETEC K88 by reducing intestinal damage, supporting antioxidative defenses, and restoring healthy gut flora.

7.5

Effective absorption

Most Useful Review

2 people found this helpful

Absorbs well. I bought this for my husband, as zinc gluconate caused him diarrhoea. This form of zinc works effectively.

Updated: Mar 2026

Bacterial Infection details

Upon receiving the zinc, I began to feel unwell. At the first signs of infection – sore throat and runny nose – I took 1 capsule a day. I didn't get sick, and everything cleared up after 2 days without any additional medication, which made me very happy.

Allergies details

Zinc may relieve allergy symptoms

Xu H, Tong K, Iwasaki N, Ohgami N, Tazaki A, et al. Alleviating effect of intranasal zinc on symptoms of allergic rhinitis. J Allergy Clin Immunol Glob. 2025;4:100408. doi:10.1016/j.jacig.2025.100408

We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.

Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.

The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.

Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.

No side effects

Most Useful Review

This zinc supplement is excellent. I feel good and have experienced no allergies or side effects while using it.

Updated: Mar 2026

Acne details

Zinc effective for acne treatment

Based on 21 Researches

Yee BE, Richards P, Sui JY, Marsch AF. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis. Dermatol Ther. 2020;33:e14252. doi:10.1111/dth.14252

We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.

Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.

Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!

Hormonal acne reduction

Most Useful Review

29 people found this helpful

I have a constant zinc deficiency and find this product useful. It helps reduce my hormonal acne, but copper is also needed.

Updated: Apr 2026

Constipation details

Zinc may mitigate granisetron constipation

Nacci C, Fanelli M, Potenza MA, Leo V, Montagnani M, et al. Carbon monoxide contributes to the constipating effects of granisetron in rat colon. World J Gastroenterol. 2016;22:9333.

We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.

Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.

Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.

Resolved constipation

Most Useful Review

Since I started taking this, my constipation issue has significantly improved.

Updated: Mar 2026

Headache details

Zinc reduces migraine symptoms

Based on 8 Researches

We conducted a randomized, double-blind, placebo-controlled trial to explore how zinc gluconate affects migraine symptoms in women. Sixty participants, with an average age of 35, were given either 15 mg of zinc per day or a placebo for 12 weeks, allowing us to measure the impact on headache frequency, duration, and intensity.

The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.

Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.

In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.

Prevents illness

Most Useful Review

This helped me greatly when others around me fell ill. At the first signs of illness, such as headache and weakness, I took zinc and avoided getting sick while my colleagues suffered severely.

Updated: Mar 2026

Food Poisoning details