Natrol Kids Melatonin Fast Dissolve Sleep Aid 1 mg

We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.

Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.

Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.

We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.

9.5

Effective for children

Most Useful Review

We tried the children's melatonin for our four-year-old, and the results are remarkable. The strawberry flavour is appealing to her. It significantly improves her sleep; she now falls asleep faster and enjoys sounder sleep, alleviating our previous insomnia struggles. We highly recommend it to parents!

Case report: Hypnic headache responds to agomelatine-a potential prophylactic treatment option.

Most Relevant Research

We explored how melatonin-based treatments, particularly agomelatine, can affect headaches, focusing on hypnic headaches (HH). This form of headache typically occurs during sleep, disrupting the rest of those affected. A fascinating case of a 58-year-old woman who experienced these nocturnal headaches for three years demonstrated the potential benefits of agomelatine.

After being prescribed 25 mg of agomelatine at bedtime, she reported an impressive 80% reduction in headache frequency and severity within a month. Remarkably, her headaches completely resolved after three months, allowing her to discontinue the medication.

This case highlights the importance of exploring prophylactic treatments aimed at reducing nighttime awakenings caused by HH. Given the significant impact these headaches can have on sleep quality in older populations, treatments that target melatonin receptors could offer a promising avenue for relieving this condition.

Relieves headache

Most Useful Review

Good melatonin. The "Melatonin 1 mg" tablets help regulate sleep and combat stress. Melatonin, a hormone produced naturally in the body, decreases with age, leading to sleep disturbances and headaches. Supplementing with melatonin aids in improving sleep and mood. It normalises blood pressure and slows down ageing processes, while also strengthening immunity. Regular intake can alleviate some types of headaches.

Anxiety

SCIENTIFIC SCORE

Questionable

Based on 6 Researches

Melatonin reduces anxiety from glyphosate

Melatonin attenuates affective disorders and cognitive deficits induced by perinatal exposure to a glyphosate-based herbicide via antioxidant pathway in adult male and female rats.

Most Relevant Research

Our research examined the effects of melatonin on anxiety and memory problems caused by exposure to glyphosate-based herbicides (GBH). We started with pregnant Wistar rats that were subjected to GBH during gestation and lactation. After weaning, the offspring were treated with melatonin to see if it could help mitigate the negative effects they experienced due to their early exposure.

We observed that exposure to GBH led to increased anxiety and depression-like behaviors in the rats. Additionally, it appeared to impair their memory function. In looking at oxidative stress markers in the brain regions associated with emotion and cognition, we found indications of increased stress—especially pronounced in the female offspring.

However, the inclusion of melatonin significantly reduced these anxiety levels and improved cognitive deficits. Interestingly, the benefits were notably greater in female rats compared to males, suggesting a potential sex-dependent response to melatonin treatment.

7.5

Child's anxiety reduction

Most Useful Review

Nighttime Anxiety. My 9-year-old child has experienced significant improvements in sleeping through the night and a reduced level of anxiety before bed since taking these. She occasionally complains of dizziness, particularly if she doesn't settle down, but overall, we’ll continue using these.

Sleep Apnea

Improved bedtime routine

Most Useful Review

This has transformed our evening routine. After four years of struggles with bedtimes, my son now asks to go to bed and sleeps well after just a week of use. This brand is well-supported, and I followed my GP’s advice in giving it to my child.

Cold

SCIENTIFIC SCORE

Moderately Effective

Based on 16 Researches

Melatonin mitigates banana cold injury

Comparative transcriptomic analysis reveals the reactive oxygen species metabolism involving in melatonin-alleviated chilling injury in postharvest banana fruit.

Most Relevant Research

We explored how melatonin treatment affects chilling injury in bananas during cold storage. The study revealed that bananas treated with 500 μmol L of melatonin significantly reduced the signs of chilling injury compared to untreated control fruits during 96 hours of storage.

We observed notable changes in the activity of reactive oxygen species (ROS) metabolism. The melatonin-treated bananas showed lower rates of ROS production while also displaying higher levels of beneficial compounds like ascorbic acid and glutathione. Furthermore, the treatment helped maintain the activity of key antioxidant enzymes that typically decline under cold stress.

A thorough analysis of gene expression found 1858 differentially expressed genes, indicating how melatonin influences various biological pathways in the fruit. Interestingly, melatonin seems to boost the expression of antioxidant enzyme genes while inhibiting the expression of a gene responsible for ROS production.

Overall, these findings provide valuable insights into how melatonin can effectively mitigate cold-related injuries in bananas, helping preserve their quality during storage.

Sleep aid for kids

Most Useful Review

These work brilliantly. We use them to maintain my five-year-old's sleep schedule, and about 30 to 45 minutes after he takes them, he is OUT COLD.