Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl and pyridoxal-5-phosphate)
50 mg
2,941%
The product is found useful for the following medical conditions
Neuropathy details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
We focused on understanding how vitamin B6 influences chronic chemotherapy-induced peripheral neuropathy (CIPN), a long-lasting side effect experienced by patients undergoing oxaliplatin-based treatment for non-metastatic colorectal cancer. Our study included 242 patients who provided blood samples at multiple points—before starting chemotherapy, during it, and after completing treatment.
We measured several vitamin B6 markers in the blood and examined their connection to the occurrence and severity of chronic CIPN a year post-diagnosis. Our findings revealed that while normal levels of a particular form of vitamin B6 were present, those with higher levels during chemotherapy reported lower instances and reduced severity of CIPN symptoms. This suggests that maintaining adequate vitamin B6 levels may be beneficial for patients facing chemotherapy-related nerve issues.
Still, it’s important to approach these results cautiously. More research is needed to firmly establish a cause-and-effect relationship and to determine the optimal vitamin B6 levels for patients undergoing chemotherapy. This insight could pave the way for better management of neuropathy among cancer patients in the future.
We measured several vitamin B6 markers in the blood and examined their connection to the occurrence and severity of chronic CIPN a year post-diagnosis. Our findings revealed that while normal levels of a particular form of vitamin B6 were present, those with higher levels during chemotherapy reported lower instances and reduced severity of CIPN symptoms. This suggests that maintaining adequate vitamin B6 levels may be beneficial for patients facing chemotherapy-related nerve issues.
Still, it’s important to approach these results cautiously. More research is needed to firmly establish a cause-and-effect relationship and to determine the optimal vitamin B6 levels for patients undergoing chemotherapy. This insight could pave the way for better management of neuropathy among cancer patients in the future.
10
Neuropathy relief
Most Useful Review
13 people found this helpful
No more neuropathy. Definitely worth the money; it helps with my neuropathy.
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.2
USERS' SCORE
Good
Based on 6 Reviews
8.5
9.5
We looked into how pyridoxine, or vitamin B6, could impact anxiety, particularly in those with a deficiency. A case study featuring a 57-year-old man with chronic alcoholism showed that he had developed anxiety and other neurological symptoms despite being on anti-epileptic medications. After discovering he had a pyridoxine deficiency, his symptoms, including anxiety, completely disappeared with vitamin B6 treatment. This highlights the potential importance of checking for pyridoxine levels in patients presenting with neurological issues, especially when anxiety is involved.
9
Improved mood
Most Useful Review
19 people found this helpful
This B vitamin complex has significantly supported my adrenal glands during stressful times. Within three days of taking it, I noticed a marked reduction in irritability and anxiety, along with stability in my mood. Overall, it has contributed positively to my emotional well-being.
Common Cold details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.5
9
Boosted immune system
Most Useful Review
This product is perfect for this time of year. It contains quality ingredients from a trusted company. The size is just right, and it tastes good, aiding my immune system during cold, flu, and stress season.
Chest Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.4
USERS' SCORE
Good
Based on 3 Reviews
8.4
8
Vitamin B6 and cardiac health
We evaluated the impact of vitamin B6 on chest pain and its potential role in preventing related cardiac issues. In our findings, we noticed that patients suffering from carpal tunnel syndrome who received vitamin B6 treatment had a significantly lower risk—about 27%—of experiencing acute chest pain or myocardial infarction compared to those who did not take the vitamin.
Additionally, among elderly patients, those who used vitamin B6 lived, on average, eight years longer before succumbing to myocardial infarction than their counterparts who didn’t use the vitamin. This suggests that vitamin B6 might play a beneficial role in heart health, particularly for those at risk of coronary heart disease, possibly due to its involvement in reducing levels of homocysteine, an amino acid linked with heart problems.
While the study combines various findings related to chest pain and myocardial infarction, the evidence we observed indicates that vitamin B6 could be helpful in reducing the risk of these heart-related conditions. However, we acknowledge the complexities in disentangling its specific effects.
Additionally, among elderly patients, those who used vitamin B6 lived, on average, eight years longer before succumbing to myocardial infarction than their counterparts who didn’t use the vitamin. This suggests that vitamin B6 might play a beneficial role in heart health, particularly for those at risk of coronary heart disease, possibly due to its involvement in reducing levels of homocysteine, an amino acid linked with heart problems.
While the study combines various findings related to chest pain and myocardial infarction, the evidence we observed indicates that vitamin B6 could be helpful in reducing the risk of these heart-related conditions. However, we acknowledge the complexities in disentangling its specific effects.
9
Nerve pain treated
Most Useful Review
I bought this for my mum to alleviate nerve pain, and she has been experiencing excellent results from taking it.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.9
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
We explored the potential of vitamin B6 in treating depression, particularly how it compares to commonly used antidepressants. In our experiment, male mice were given a single dose of Bacillus-Calmette-Guerin (BCG) to induce depressive-like behaviors. Following this, we administered vitamin B6 alongside popular antidepressants such as fluoxetine, imipramine, and venlafaxine, to see how effectively each treatment mitigated symptoms over 14 days.
Our findings highlighted that vitamin B6 was effective in alleviating depression in the mice, just like the other antidepressant medications. The animals displayed significant improvements in both despair and anhedonia—key indicators of depression. Specifically, we noticed a decrease in immobility time during a forced swim test, indicating reduced despair. Plus, the latency to feed and food consumption improved significantly, showing that vitamin B6 helped counteract the depressive behaviors caused by BCG.
Overall, our research suggests that vitamin B6 can be a powerful ally in preventing depression, similar in effectiveness to some existing antidepressant drugs. We believe this opens the door for further clinical research on vitamin B6 as a potential treatment, especially for those at high risk for depression.
Our findings highlighted that vitamin B6 was effective in alleviating depression in the mice, just like the other antidepressant medications. The animals displayed significant improvements in both despair and anhedonia—key indicators of depression. Specifically, we noticed a decrease in immobility time during a forced swim test, indicating reduced despair. Plus, the latency to feed and food consumption improved significantly, showing that vitamin B6 helped counteract the depressive behaviors caused by BCG.
Overall, our research suggests that vitamin B6 can be a powerful ally in preventing depression, similar in effectiveness to some existing antidepressant drugs. We believe this opens the door for further clinical research on vitamin B6 as a potential treatment, especially for those at high risk for depression.
7.5
Effective for depression
Most Useful Review
6 people found this helpful
I started taking it due to low ASt and ALt levels, which indicate a lack of B6 and high homocysteine. It helps in improving glucose metabolism and lowers blood sugar levels. B6 acts as a diuretic, reducing fluid retention and blood pressure. It is effective for depression and anxiety, especially alongside magnesium. When taken with Q10, it also aids concentration, while B6 and its transdermal forms can help with acne and skin conditions.
Knee Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 2 Reviews
8.4
8
We conducted an open-label study to assess how a seaweed extract formulation, which includes Vitamin B6, impacts knee osteoarthritis symptoms. Involving 12 participants with confirmed knee osteoarthritis, we divided them into two groups receiving either 100 mg or 1000 mg of the extract daily.
Our primary focus was to measure overall joint health through a score that looked at pain, stiffness, and physical activity challenges over twelve weeks. While we found a general improvement in osteoarthritis symptoms with increased dosage of the extract, it’s important to note that Vitamin B6 was part of a combined treatment with other nutrients. This means we cannot determine the isolated effect of Vitamin B6 on knee pain from our findings alone.
We observed no significant safety concerns during the study, and the treatment was well tolerated. However, further research in a larger, controlled study is needed to fully understand the role of Vitamin B6 within this formulation and its true effectiveness on knee osteoarthritis.
Our primary focus was to measure overall joint health through a score that looked at pain, stiffness, and physical activity challenges over twelve weeks. While we found a general improvement in osteoarthritis symptoms with increased dosage of the extract, it’s important to note that Vitamin B6 was part of a combined treatment with other nutrients. This means we cannot determine the isolated effect of Vitamin B6 on knee pain from our findings alone.
We observed no significant safety concerns during the study, and the treatment was well tolerated. However, further research in a larger, controlled study is needed to fully understand the role of Vitamin B6 within this formulation and its true effectiveness on knee osteoarthritis.
9
Effective nerve relief
Most Useful Review
I purchased this for my mum to alleviate nerve pain, and she has been experiencing very good results since taking it.
Liver Disease details
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.5
USERS' SCORE
Good
Based on 2 Reviews
8.4
9
Vitamin B6 shows antioxidant effects
We explored the effects of vitamin B6 on liver damage caused by chromium-related oxidative stress in a study involving adult male Wistar rats. The rats received potassium dichromate to induce oxidative stress, while vitamin B6 was given either before or simultaneously with the chromium treatment.
Our findings revealed that vitamin B6 significantly countered oxidative stress, with pre-treatment proving to be more effective than simultaneous administration. This highlights the antioxidant potential of vitamin B6, showcasing its promise in protecting the liver from chromium-induced harm.
Our findings revealed that vitamin B6 significantly countered oxidative stress, with pre-treatment proving to be more effective than simultaneous administration. This highlights the antioxidant potential of vitamin B6, showcasing its promise in protecting the liver from chromium-induced harm.
7.5
Supports liver function
Most Useful Review
2 people found this helpful
Good vitamin B6 in its active form. If anyone has issues with detoxification or liver disease, I recommend considering this supplement.
Menopause details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.2
USERS' SCORE
Good
Based on 4 Reviews
8.4
8
We investigated how dietary factors, particularly vitamin B6, influence the timing of natural menopause in women. Our study focused on women aged 40 to 65 who completed a food frequency questionnaire and recorded their reproductive history.
Over a 4-year follow-up period, we found that a higher intake of vitamin B6 was associated with a delay in the onset of menopause. Specifically, each additional milligram of vitamin B6 consumed each day was linked with a postponement of menopause by 0.6 years. While this suggests that increasing vitamin B6 intake could be beneficial for delaying menopause, it’s important to note that this effect was not isolated from other dietary influences, which may complicate our understanding of its specific role.
We also observed that certain foods like oily fish and fresh legumes were associated with later menopause, while refined pasta and rice were linked to earlier menopause. Our findings underline the potential influence of diet on menopause timing, though we must approach the effects of vitamin B6 with the understanding that it may not act alone.
Over a 4-year follow-up period, we found that a higher intake of vitamin B6 was associated with a delay in the onset of menopause. Specifically, each additional milligram of vitamin B6 consumed each day was linked with a postponement of menopause by 0.6 years. While this suggests that increasing vitamin B6 intake could be beneficial for delaying menopause, it’s important to note that this effect was not isolated from other dietary influences, which may complicate our understanding of its specific role.
We also observed that certain foods like oily fish and fresh legumes were associated with later menopause, while refined pasta and rice were linked to earlier menopause. Our findings underline the potential influence of diet on menopause timing, though we must approach the effects of vitamin B6 with the understanding that it may not act alone.
9
Helpful during menopause
Most Useful Review
I've ordered this brand before; the quality is excellent, and the ingredients have been tested for over a year. It's a great support for women during menopause and a necessary supplement. I've been consistently satisfied with the quality, and I'll be ordering this again as it promotes health at any age. The large packaging size ensures it lasts a long time, which pleases me.
Sleep Apnea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Calmer sleep experience
Most Useful Review
13 people found this helpful
After struggling to find the right Magnesium B6, I started taking them separately and felt the effect! I take them at night, and my sleep has improved, especially as I recover from Covid, which had caused migraines and heightened skin sensitivity.
Anemia details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.7
USERS' SCORE
Good
Based on 4 Reviews
8.3
9.5
We observed a compelling case involving a 32-year-old pregnant woman who experienced severe anemia during her pregnancy. This specific type of anemia, known as sideroblastic anemia, is quite rare in expectant mothers. The patient had been feeling weak and had heart palpitations for two weeks when she came to the emergency room.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
7.5
Supports anaemia treatment
Most Useful Review
10 people found this helpful
I recommend this complex, which contains two forms of vitamin B6. Vitamin B6 is vital for synthesising neurotransmitters, and a deficiency can lead to memory decline, depression, and anxiety. It is also essential in preventing anaemia by aiding the formation of haemoglobin. Furthermore, vitamin B6 is crucial for magnesium absorption and nitrogen dioxide elimination. Symptoms of deficiency include low ALT and AST levels and high homocysteine.
Heart Attack details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.2
USERS' SCORE
Good
Based on 4 Reviews
8.3
9
We explored the potential of vitamin B6 (VB6) in promoting recovery after heart attacks, specifically its role in angiogenesis, which is the formation of new blood vessels. The study aimed to determine whether VB6 could help prevent cardiac dysfunction following acute myocardial infarction (AMI).
To assess the effects of VB6, we conducted both in vitro experiments, examining endothelial cell behavior, and in vivo tests using mice with heart attacks. We discovered that VB6 significantly enhanced cell migration and tubule formation in human umbilical vein endothelial cells, which are critical for blood vessel formation. This process was linked to increased activity of a protein called AMP-activated protein kinase (AMPK).
Interestingly, our findings showed that these beneficial effects of VB6 were reversed when we introduced AMPK inhibitors. This leads us to conclude that VB6 promotes heart recovery by activating AMPK, which in turn supports angiogenesis following AMI. In practical terms, long-term VB6 supplementation after heart attacks led to improved heart function and increased new blood vessel formation in mice, making this vitamin a promising candidate for heart recovery therapies.
To assess the effects of VB6, we conducted both in vitro experiments, examining endothelial cell behavior, and in vivo tests using mice with heart attacks. We discovered that VB6 significantly enhanced cell migration and tubule formation in human umbilical vein endothelial cells, which are critical for blood vessel formation. This process was linked to increased activity of a protein called AMP-activated protein kinase (AMPK).
Interestingly, our findings showed that these beneficial effects of VB6 were reversed when we introduced AMPK inhibitors. This leads us to conclude that VB6 promotes heart recovery by activating AMPK, which in turn supports angiogenesis following AMI. In practical terms, long-term VB6 supplementation after heart attacks led to improved heart function and increased new blood vessel formation in mice, making this vitamin a promising candidate for heart recovery therapies.
9
Heart health improvement
Most Useful Review
Powerful supplement for heart health. It contributed to my overall heart health and helped lower my blood pressure when combined with diet and exercise changes.
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.3
9
Positive gastrointestinal effects
Most Useful Review
3 people found this helpful
Amazing! Vitamin B6 has a good composition and no unnecessary fillers. This company’s B6 provides therapeutic effects, particularly beneficial for the central nervous system and leg cramps. It maintains hormone balance, supports immunity, and aids protein metabolism. I'm grateful for the positive impact on my gastrointestinal health, relieving numbness and pain in my legs.
Migraine details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.1
USERS' SCORE
Good
Based on 5 Reviews
8.3
7
We delved into the relationship between migraine and vitamins known to lower homocysteine levels, specifically B6, folate, and B12. Our systematic search revealed twelve articles, indicating that while managing acute migraines didn’t yield strong results, B6 supplementation showed significant benefits in preventing migraine with aura when compared to placebo.
Unfortunately, folate alone didn’t perform better than placebo for migraines, and data on migraines without aura was limited. Overall, these vitamins seem to have a safe profile, especially for migraine with aura in adults, although more high-quality trials are needed for broader conclusions.
Unfortunately, folate alone didn’t perform better than placebo for migraines, and data on migraines without aura was limited. Overall, these vitamins seem to have a safe profile, especially for migraine with aura in adults, although more high-quality trials are needed for broader conclusions.
7.5
Helpful vitamins
Most Useful Review
3 people found this helpful
Great and Important Vitamins! I buy these for my son as he suffers from migraines. They are very helpful and are part of his regimen, as recommended by his neurologist. I highly recommend them!
Nausea details
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.5
USERS' SCORE
Good
Based on 9 Reviews
8.3
9
We evaluated the effects of various treatments for nausea during early pregnancy, focusing on pyridoxine, or vitamin B6. Analyzing 28 trials, we found that pyridoxine showed promise in reducing nausea severity for those with milder symptoms. While anti-emetic medications overall helped reduce nausea significantly, we noted that more information is needed on their side effects and impact on fetal outcomes. Nevertheless, pyridoxine stands out as a useful option, with no evidence linking it to adverse fetal effects.
7.5
Effective against nausea
Most Useful Review
22 people found this helpful
Better than tablets. I take unisom and B6 to help with extreme pregnancy nausea. I cannot swallow B6 tablets because my gag reflex is too sensitive this pregnancy. Most of the time, I'm able to get these B6 capsules down easily. They are a standard size, flavourless, etc. They work well but are considerably more expensive than the tablets. However, it is better than continuing to vomit daily.
Premenstrual Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.3
9
Increased energy
Most Useful Review
Excellent quality! After testing with my gynecologist, I found a low Vitamin B6 level. After taking one package, my levels returned to normal! My overall energy has increased, and it alleviates premenstrual syndrome. The package lasts for 3 months and the taste is neutral.
Acne details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 6 Reviews
8.2
7
We explored the effects of pyridoxine, a form of vitamin B6, on skin health, focusing particularly on its potential benefits for those struggling with acne. Our research indicates that pyridoxine plays a significant role in maintaining the function of the epidermis, the outermost layer of our skin.
Through our examination of normal human epidermal keratinocytes, we observed that pyridoxine enhances the expression of profilaggrin mRNA, a precursor to filaggrin—a key protein involved in skin hydration and barrier function. The results show that treatment with pyridoxine leads to an increased production of filaggrin protein, and this effect is concentration-dependent.
While the study did not isolate findings specifically focused on treating acne alone, the increase in filaggrin production suggests that vitamin B6 might contribute positively to skin conditions related to dryness and irritation, which often accompany acne-prone skin. Our findings suggest that pyridoxine could be a valuable daily care ingredient for those with atopic dermatitis or skin issues associated with low filaggrin levels.
Through our examination of normal human epidermal keratinocytes, we observed that pyridoxine enhances the expression of profilaggrin mRNA, a precursor to filaggrin—a key protein involved in skin hydration and barrier function. The results show that treatment with pyridoxine leads to an increased production of filaggrin protein, and this effect is concentration-dependent.
While the study did not isolate findings specifically focused on treating acne alone, the increase in filaggrin production suggests that vitamin B6 might contribute positively to skin conditions related to dryness and irritation, which often accompany acne-prone skin. Our findings suggest that pyridoxine could be a valuable daily care ingredient for those with atopic dermatitis or skin issues associated with low filaggrin levels.
9
Skin condition improved
Most Useful Review
I bought this brand with B12 and feel it has improved my skin condition; I no longer suffer from acne. The effects are noticeable, and I usually take them after breakfast.
Autoimmune Disorder details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
USERS' SCORE
Good
Based on 2 Reviews
8.2
8
Vitamin B6 improves cognitive function
We conducted an intriguing study that looked into how vitamin B6 affects cognitive function in patients with Neuromyelitis Optica Spectrum Disorder (NMOSD). This autoimmune disorder often brings along cognitive challenges, so understanding potential dietary influences could be beneficial.
By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.
Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.
Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.
By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.
Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.
Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.
7.5
Supportive effects
Most Useful Review
3 people found this helpful
Incredible! The Vitamin B6 is effectively formulated without unnecessary fillers. It supports the central nervous system and is essential for those with gastrointestinal issues and autoimmune disorders. This vitamin can prevent aging, bolster immunity, and aid in protein metabolism. I’ve noticed a positive impact on my health and the relief from discomfort in my legs.
Cardiovascular Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8.2
9
We investigated the potential of vitamin B6, in the form of pyridoxal-5'-phosphate (PLP), to influence blood pressure, particularly in the context of hypertension. Our focus was on how PLP modifies angiotensin II, a peptide that plays a critical role in blood vessel constriction, transforming it into a different form known as pyruvamide-Ang II (Ang P).
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
9
Supports cardiovascular health
Most Useful Review
Nature's Way Vitamin B6 is a key supplement for various bodily functions, including amino acid metabolism and nerve system support. It aids in neurotransmitter production, which impacts mood and cognition, while also supporting hemoglobin formation. Additionally, it helps lower homocysteine levels, potentially reducing the risk of cardiovascular disease. This supplement boosts energy, improves cognitive function, and reduces stress.
Carpal Tunnel Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.2
7.5
Minimised pain
Most Useful Review
2 people found this helpful
Helps with Carpal Tunnel Syndrome. I take two capsules daily, and the pain in my wrists is minimised.
Insomnia details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 9 Reviews
8.2
9
We set out to investigate how vitamin B6 contributes to improving sleep quality in individuals experiencing mild to moderate insomnia. Our study involved 40 participants who were given a combination treatment containing melatonin, vitamin B6, and extracts from various medicinal plants.
Over a period of two weeks, participants documented their sleep experiences using a daily electronic diary. We analyzed changes in sleep quality, total sleep duration, and how well our treatment reduced sleep-related daytime impairments. Encouragingly, participants reported a significant improvement in sleep quality, with an average score rise from 5.4 to 7.3 on a 10-point scale.
Although it is difficult to isolate the specific effects of vitamin B6 alone due to its use alongside other ingredients, our findings do suggest that this vitamin, when combined with melatonin and plant extracts, could support better sleep. Importantly, the treatment was well-tolerated, with no serious side effects reported.
Overall, while vitamin B6 on its own wasn’t examined, its inclusion in a combination treatment appears to play a role in enhancing sleep quality for those struggling with insomnia.
Over a period of two weeks, participants documented their sleep experiences using a daily electronic diary. We analyzed changes in sleep quality, total sleep duration, and how well our treatment reduced sleep-related daytime impairments. Encouragingly, participants reported a significant improvement in sleep quality, with an average score rise from 5.4 to 7.3 on a 10-point scale.
Although it is difficult to isolate the specific effects of vitamin B6 alone due to its use alongside other ingredients, our findings do suggest that this vitamin, when combined with melatonin and plant extracts, could support better sleep. Importantly, the treatment was well-tolerated, with no serious side effects reported.
Overall, while vitamin B6 on its own wasn’t examined, its inclusion in a combination treatment appears to play a role in enhancing sleep quality for those struggling with insomnia.
9
Improved sleep quality
Most Useful Review
17 people found this helpful
I was prescribed vitamin B6 due to a deficiency, as my hair was falling out and I was experiencing insomnia. After a few days of taking it, I've noticed a positive change; my sleep has improved, and my overall mood has enhanced. I recommend it for everyone!
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.3
USERS' SCORE
Good
Based on 5 Reviews
8.1
8
We explored how vitamin B6, along with other B vitamins like folate and B12, might help in preventing migraines. Through a thorough review of existing research, we discovered that while vitamin B6 showed some promise in reducing migraines with aura in adults, the results aren’t as clear-cut for individuals suffering from other forms of headaches. In fact, in the context of treating acute migraine attacks, the benefits of these vitamins have not been supported by strong evidence from studies.
We found several trials that looked specifically at vitamin B6 for migraine prevention. The results were generally positive, especially for those experiencing migraines with aura, where vitamin B6 exhibited significant benefits against placebo in multiple studies. However, when it comes to folate, using it alone didn’t show improved outcomes compared to placebo. Limited data on children and those suffering from migraines without aura prevented us from making definitive conclusions about vitamin B6’s effectiveness across different demographics.
Overall, there’s a potential positive effect of vitamin B6 in managing migraines, particularly in adults with aura. While the safety profile appears favorable, we advocate for more high-quality research to clarify its role in treating various types of migraines.
We found several trials that looked specifically at vitamin B6 for migraine prevention. The results were generally positive, especially for those experiencing migraines with aura, where vitamin B6 exhibited significant benefits against placebo in multiple studies. However, when it comes to folate, using it alone didn’t show improved outcomes compared to placebo. Limited data on children and those suffering from migraines without aura prevented us from making definitive conclusions about vitamin B6’s effectiveness across different demographics.
Overall, there’s a potential positive effect of vitamin B6 in managing migraines, particularly in adults with aura. While the safety profile appears favorable, we advocate for more high-quality research to clarify its role in treating various types of migraines.
7.5
Enhances magnesium effect
Most Useful Review
I take it to boost the effectiveness of magnesium when I have a headache.
Heart Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
USERS' SCORE
Good
Based on 4 Reviews
8.1
8
We explored the effects of pyridoxamine (PM), a form of vitamin B6, on heart health in a study involving male rats. These rats were divided into two groups: one received a standard diet, while the other was fed a Western diet known to induce prediabetes. To see how PM might help, we gave one group of rats on the Western diet an additional PM supplement through their drinking water for 18 weeks.
Throughout the study, we measured glucose levels and evaluated heart function using echocardiography, alongside analyzing heart tissue for any changes. Remarkably, the rats that received PM showed less increase in fasting blood glucose compared to those on the Western diet alone. Additionally, the PM treatment seemed to prevent some heart enlargement that typically occurs alongside unhealthy diets.
Furthermore, PM was effective in limiting collagen buildup within the heart tissue, which is often a marker of heart stress or damage. We also noted a reduction in substances related to oxidative stress, suggesting that PM might protect against heart damage by reducing harmful compounds. In summary, our findings suggest that pyridoxamine may help alleviate issues related to heart structure and stress in rats at risk of developing heart disease due to prediabetes.
Throughout the study, we measured glucose levels and evaluated heart function using echocardiography, alongside analyzing heart tissue for any changes. Remarkably, the rats that received PM showed less increase in fasting blood glucose compared to those on the Western diet alone. Additionally, the PM treatment seemed to prevent some heart enlargement that typically occurs alongside unhealthy diets.
Furthermore, PM was effective in limiting collagen buildup within the heart tissue, which is often a marker of heart stress or damage. We also noted a reduction in substances related to oxidative stress, suggesting that PM might protect against heart damage by reducing harmful compounds. In summary, our findings suggest that pyridoxamine may help alleviate issues related to heart structure and stress in rats at risk of developing heart disease due to prediabetes.
9
Prevents heart disease
Most Useful Review
Vitamin B6 plays a crucial role in the body's biochemical processes and cholesterol regulation. Its deficiency can lead to heart disease and anaemia. B6 supports the heart muscle, blood vessels, and immune function.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
USERS' SCORE
Good
Based on 9 Reviews
8
4
Vitamin B6 and CFS relationship
We observed the functional status of vitamin B6, also known as pyridoxine, in patients suffering from chronic fatigue syndrome (CFS). Our study involved comparing 12 untreated CFS patients with 18 healthy individuals, matched for age and sex.
To assess the vitamin B6 status, we measured aspartate aminotransferase (AST) levels, among other key enzymes. Our findings revealed that the basal activity of AST was significantly lower in the CFS patients compared to the healthy controls.
This trend was consistent for other vitamins related to fatigue, like riboflavin and thiamine, where basal activity was also found to be lower in CFS patients. Importantly, even after supplementation in the lab, the overall activation ratios between both groups didn’t differ significantly.
Although our results suggest a reduced functional status of vitamin B6 in CFS patients, the lack of significant changes after vitamin activation indicates that vitamin B6 treatment alone may not be a definitive answer to combatting chronic fatigue syndrome. More research is necessary to understand the full role of B6 and its potential benefits.
To assess the vitamin B6 status, we measured aspartate aminotransferase (AST) levels, among other key enzymes. Our findings revealed that the basal activity of AST was significantly lower in the CFS patients compared to the healthy controls.
This trend was consistent for other vitamins related to fatigue, like riboflavin and thiamine, where basal activity was also found to be lower in CFS patients. Importantly, even after supplementation in the lab, the overall activation ratios between both groups didn’t differ significantly.
Although our results suggest a reduced functional status of vitamin B6 in CFS patients, the lack of significant changes after vitamin activation indicates that vitamin B6 treatment alone may not be a definitive answer to combatting chronic fatigue syndrome. More research is necessary to understand the full role of B6 and its potential benefits.
9
Better sleep quality
Most Useful Review
Vitamin B6 was recommended for my chronic fatigue syndrome, poor sleep, irritability, and fatigue. After completing the course, I feel significantly better.
Dizziness details
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
5.7
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.9
5
We conducted a randomized, triple-blinded controlled trial to examine how daily doses of 150 mg of vitamin B6 might influence dizziness and other side effects for women starting low-dose oral contraceptives. Our study included 124 participants, and we measured various symptoms such as nausea, headache, and dizziness on a scale from 0 to 3, at both the start and one month later.
Interestingly, both the group taking vitamin B6 and the placebo group experienced a reduction in symptom severity over time. While we noticed that women taking vitamin B6 reported slightly greater improvements in headaches and dizziness compared to those on placebo, the differences weren't statistically significant. This suggests that the observed benefits could be more related to the placebo effect rather than a strong therapeutic impact from vitamin B6.
In summary, while vitamin B6 may provide some relief for dizziness associated with low-dose oral contraceptives, the evidence points to a lack of substantial benefit compared to a placebo.
Interestingly, both the group taking vitamin B6 and the placebo group experienced a reduction in symptom severity over time. While we noticed that women taking vitamin B6 reported slightly greater improvements in headaches and dizziness compared to those on placebo, the differences weren't statistically significant. This suggests that the observed benefits could be more related to the placebo effect rather than a strong therapeutic impact from vitamin B6.
In summary, while vitamin B6 may provide some relief for dizziness associated with low-dose oral contraceptives, the evidence points to a lack of substantial benefit compared to a placebo.
9
Nausea relief
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2 people found this helpful
I took it for nausea and dizziness during pregnancy, and I noticed an improvement from the first use; I no longer experience morning sickness. I took it with magnesium to enhance absorption and improve sleep quality, taking it at night before bed.
Back Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.7
7
Vitamin B6's role in back pain
We examined the potential benefits of vitamin B6 in treating back pain, paying attention to how it works alone and in combination with other pain relievers. Research suggests that when high doses of vitamin B6 are used, they may enhance the effects of non-opioid analgesics like NSAIDs, making them more effective in alleviating pain.
Interestingly, vitamin B6 has shown specific promise in conditions like carpal tunnel syndrome, which is sometimes linked to a deficiency of this vitamin. It's also noted that vitamin B6 can improve the efficiency of medications like diclofenac in managing acute low-back pain. This means that patients might enjoy reduced pain with either lower doses or shorter treatment times with their usual medications.
However, it’s important to keep in mind that while there are positive indications, the effectiveness of B6 for chronic back pain remains uncertain. Overall, while we found some encouraging signs for vitamin B6 in back pain management, more rigorous evaluations are needed to truly gauge its long-term effectiveness and safety.
Interestingly, vitamin B6 has shown specific promise in conditions like carpal tunnel syndrome, which is sometimes linked to a deficiency of this vitamin. It's also noted that vitamin B6 can improve the efficiency of medications like diclofenac in managing acute low-back pain. This means that patients might enjoy reduced pain with either lower doses or shorter treatment times with their usual medications.
However, it’s important to keep in mind that while there are positive indications, the effectiveness of B6 for chronic back pain remains uncertain. Overall, while we found some encouraging signs for vitamin B6 in back pain management, more rigorous evaluations are needed to truly gauge its long-term effectiveness and safety.
7.5
Minimised pain
Most Useful Review
2 people found this helpful
This helps with Carpal Tunnel Syndrome. I take two capsules daily, which has really minimised the pain in my wrists.
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.7
USERS' SCORE
Moderately Good
Based on 6 Reviews
7
9
Vitamin B6 reduces cholesterol levels
We aimed to understand how Vitamin B6 influences high cholesterol levels, particularly through its effects on lipid metabolism in rats induced by a high-fat diet. To set the stage for our exploration, we used male Sprague-Dawley rats and placed them on this fat-rich diet for two weeks to establish a hyperlipidemia model.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
9
Aids in metabolism
Most Useful Review
3 people found this helpful
Founded in 1969, Cellular Energy Support’s Vitamin B6 is essential for amino acid and protein metabolism, while also contributing to the production of serotonin. It's rigorously tested for quality.
