NOW Supplements Niacin (Vitamin B-3)

6 people found this helpful

My knee feels numb due to an injury, and I've been taking 6g of niacin daily as advised by an acquaintance. I notice significant help in my recovery and pain relief, without any side effects, so I plan to continue taking it.

Anxiety details

Inositol reduces anxiety in hens

Questionable

Based on 8 Researches

Herwig E, Classen HL, Walk CL, Bedford M, Schwean-Lardner K. Dietary Inositol Reduces Fearfulness and Avoidance in Laying Hens. Animals (Basel). 2019;9. doi:10.3390/ani9110938

We conducted a study to understand how inositol, a naturally occurring sugar alcohol, influences anxiety levels in laying hens. Our focus was on the behavior of Lohmann LSL lite hens, which were fed two different diets—one rich and one deficient in protein—while receiving either pure inositol or high levels of phytase.

Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.

Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.

Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.

7.5

Natural treatment for OCD

Most Useful Review

24 people found this helpful

This product is excellent for OCD challenges. I weigh about 195lbs and take 2x3 of these daily. I've become more relaxed and experience significantly less anxiety about minor issues. It began to work in less than a week without any flushing.

Updated: Mar 2026

Arthritis details

Niacin may lower osteoarthritis risk

Based on 3 Researches

Lv X, Deng X, Lai R, Liu S, Zou Z, et al. Association between niacin intake and osteoarthritis in the US population based on NHANES 1999-2018. Sci Rep. 2025;15:6470. doi:10.1038/s41598-025-91063-3

We aimed to understand the relationship between niacin intake and osteoarthritis (OA) by analyzing data from the National Health and Nutrition Examination Survey spanning from 1999 to 2018. With over 30,000 participants in the study and almost 2,000 diagnosed with osteoarthritis, we found some interesting results.

Our analysis used advanced statistical methods to explore how different levels of niacin intake affected the risk of developing OA. What we discovered was that higher niacin intake was consistently associated with a reduced risk of osteoarthritis. In fact, participants in the highest intake group had a remarkable 33% lower risk compared to those in the lowest intake group.

We also noticed that there’s a non-linear relationship; once we reach an inflection point in niacin intake, the way it impacts OA risk changes. The results were particularly striking in Non-Hispanic Black individuals and others in different racial groups.

Overall, this research suggests that by increasing the consumption of niacin-rich foods, we may be able to reduce the risk of developing osteoarthritis. However, further investigations are needed to confirm these findings and explore the potential of niacin as an effective dietary approach to OA prevention and treatment.

7.5

Significant improvement

Most Useful Review

1 people found this helpful

Niacin combined with apple pectin has considerably improved several types of rheumatoid arthritis over six years. I recommend it for anyone struggling with similar conditions.

Updated: Mar 2026

Common Cold details

Having used niacin for some time, I would experience a flush, leading me to take it at night, but it disrupted my sleep. I tried this flash-free version, and it worked well without causing any flush, allowing me to drink it at any time. It’s ideal for those who suffer from flush.

Updated: Apr 2025

Headache details

Taking normal niacin gave me headaches, but this variant does not cause that issue at all. I highly recommend it to anyone who experiences similar headaches.

104 people found this helpful

Hot Flashes details

I took it as prescribed by an endocrinologist for three months; the doctor recommended this specific product from the entire range of niacins available on iHerb. There were no side effects, redness, or allergies. The hot flashes have become less intense, with their frequency reduced to 2-3 per day, which I found acceptable.

Menopause details

Myo-Inositol Support in Menopause

Based on 9 Researches

Cho KA, Kim YH, Woo SY, Ryu KH. Tonsil-Derived Mesenchymal Stem Cell-Derived Small Extracellular Vesicles (sEVs) Restore Myo-Inositol Production in LPS-Treated Skeletal Muscle. Tissue Eng Regen Med. 2025. doi:10.1007/s13770-025-00709-w

We investigated whether small extracellular vesicles (sEVs) derived from human palatine tonsil mesenchymal stem cells could boost myo-inositol levels in the context of menopause. This was particularly interesting given that menopausal women are prone to chronic inflammation due to physiological changes and related issues like metabolic syndrome.

To explore this, we treated mice with lipopolysaccharides (LPS) to simulate inflammation and assessed how the inclusion of T-MSC sEVs influenced myo-inositol production. After treatment, we measured levels of proteins involved in inositol synthesis in skeletal muscle and checked the serum for inositol levels.

Our findings are encouraging and suggest that T-MSC sEVs might help mitigate some effects of chronic inflammation linked to menopause. By supporting skeletal muscle mass and maintaining myo-inositol levels, these sEVs could be an effective strategy for improving metabolic health in menopausal women. This study sheds light on a potential new approach to tackle metabolic disturbances during this life stage.

7.5

Energy boost

Most Useful Review

This supplement provides a surge of energy and helps alleviate menopause symptoms. My migraines have also become less disruptive.

Updated: Mar 2026

Acne details

Myo-inositol improves acne symptoms

Based on 11 Researches

Zacchè MM, Caputo L, Filippis S, Zacchè G, Dindelli M, et al. Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. Gynecol Endocrinol. 2009;25:508. doi:10.1080/09513590903015544

We explored the effects of myo-inositol (MYO) on acne among young women diagnosed with polycystic ovary syndrome (PCOS). The study included 50 participants who underwent treatment with MYO for six months, focusing on its potential to improve the often frustrating skin issues linked to PCOS.

At the beginning and after the treatment period, we measured various factors including levels of hormones and insulin, as well as the severity of acne.

Remarkably, after three months of MYO therapy, we observed significant reductions in hormone levels associated with PCOS, particularly testosterone and insulin. After six months, both hirsutism and acne symptoms showed notable improvement among the participants.

This research highlights MYO as a promising, safe treatment option for alleviating acne symptoms in individuals with PCOS. Its ability to improve metabolic conditions while managing acne is a fascinating development for women seeking effective solutions for their skin concerns.

Reduced pimples

Most Useful Review

1 people found this helpful

I purchased this on my cosmetologist's recommendation! Niacinamide helps regulate sebum production, and its antimicrobial and anti-inflammatory properties lessen the activity of acne-causing bacteria. It diminishes redness, reduces the number of spots, and aids in healing acne scars. After taking it for a month, I noticed significantly fewer spots on my face; it could be my new skincare routine or these vitamins.

Updated: Apr 2026

Autoimmune Disorder details

Myo-inositol enhances vitamin D effects

Questionable

Based on 5 Researches

Krysiak R, Kowalcze K, Okopień B. The impact of vitamin D on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in myo-inositol-treated and myo-inositol-naïve women with autoimmune thyroiditis: A pilot study. J Clin Pharm Ther. 2022;47:1759. doi:10.1111/jcpt.13730

Our study aimed to explore the impact of myo-inositol treatment on thyroid autoimmunity in women with autoimmune thyroiditis. We included groups of women who had been on myo-inositol for a while and those who hadn’t. For six months, we observed how vitamin D supplementation interacted with myo-inositol in affecting thyroid health and immune responses.

We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.

Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.

Good quality price

Most Useful Review

This affordable niacin suits me well; the price matches the quality, and I'll definitely order it again.

Updated: Mar 2026

Cancer details

Myo-inositol affects prostate cancer cells

Based on 4 Researches

Islam MJ, Muntaha S, Masum MM, Nowshin S, Salam S, et al. Proteomic Analysis of Anticancer Effect of Myo-inositol in Human Prostate Cancer (DU-145) Cell Line. Asian Pac J Cancer Prev. 2024;25:4447. doi:10.31557/APJCP.2024.25.12.4447

We investigated the potential benefits of Myo-inositol, a naturally occurring sugar alcohol, on DU-145 prostate cancer cells. By treating these cancer cells with various doses of Myo-inositol, we determined its half-maximal inhibitory concentration (IC50) using a simple method that measures cell viability.

Our findings revealed that Myo-inositol significantly decreased the viability of DU-145 cells, showing an IC50 of 0.06 mg/ml. This suggests that Myo-inositol may effectively inhibit cancer cell growth.

Furthermore, we performed a detailed proteomic analysis using advanced techniques to explore how Myo-inositol changes protein expression. We found notable differences in protein levels between treated and untreated cells, particularly in areas linked to key cellular functions like cytoskeletal regulation, apoptosis (cell death), and stress responses. For instance, certain proteins tied to tumor suppression were upregulated in response to Myo-inositol treatment.

Overall, these observations highlight Myo-inositol's potential as a therapeutic option. However, further studies are necessary to unravel the underlying mechanisms and assess its effectiveness in combination with other treatments for managing prostate cancer, especially castration-resistant prostate cancer (CRPC).

7.5

Assists cancer treatment

Most Useful Review

Cornsine is beneficial in the battle against cancer; I genuinely hope to assist my friends!

Updated: Apr 2025

Chronic Fatigue Syndrome details

1 people found this helpful

After hearing that niacin is effective for fatigue, I started taking it two weeks ago. It seems to help – I find it less difficult to manage my fatigue than before. The no-flush formula avoids the unwanted redness effect, making it a comfortable choice. I recommend it for those suffering from fatigue.

Updated: Apr 2025

Heart Disease details

Inositol boosts heart protective adiponectin

Based on 3 Researches

Fu L, Du J, Furkert D, Shipton ML, Liu X, et al. Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin. Cardiovasc Res. 2024;120:954. doi:10.1093/cvr/cvae017

Our research focused on understanding how inositol, specifically a molecule called 5-InsP7, plays a role in heart health by influencing levels of a substance called adiponectin. Adiponectin is important because it helps protect against cardiovascular issues and metabolic disorders.

We discovered that the enzyme inositol hexakisphosphate kinase 1 (IP6K1) produces 5-InsP7, which helps regulate how much adiponectin is available in the bloodstream. This regulation occurs through a process that ensures adiponectin stays stable instead of degrading within the cells.

When we decreased the levels of 5-InsP7—either by knocking out the gene responsible for producing it or through specific drug treatments—we noticed a significant increase in adiponectin levels in the plasma. This increase particularly favored the high molecular weight forms of adiponectin, which are particularly beneficial for heart protection.

The findings suggest that targeting 5-InsP7 could be a promising strategy for enhancing adiponectin levels, potentially offering a new avenue for protecting the heart against damage from conditions like ischemia-reperfusion injury, which occurs when blood flow returns to the heart after a period of blockage.

Overall, this study gives insight into how inositol treatment might help heart disease, emphasizing the importance of adiponectin in cardiovascular health.

7.5

Restores heart function

Most Useful Review

4 people found this helpful

Niacin is crucial for maintaining and restoring heart function, as noted in Lorna Vanderay's programme, "Your 30 Days Heart Smart Solution".

Updated: Mar 2026

Insomnia details

Improved sleep quality

3 people found this helpful

Niacin for insomnia. I initially took niacinamide, but when I switched to this non-flush type niacin, I could stop using sleeping pills smoothly. I began with 500mg and increased it to 3000mg. Along with it, I also take two-pardy, magnesium, vitamin B12, etc.

Irritable Bowel Syndrome details

Supplement improves IBS symptoms

Based on 2 Researches

Spagnuolo R, Cosco C, Mancina RM, Ruggiero G, Garieri P, et al. Beta-glucan, inositol and digestive enzymes improve quality of life of patients with inflammatory bowel disease and irritable bowel syndrome. Eur Rev Med Pharmacol Sci. 2017;21:102.

We explored how a mixture of beta-glucan, inositol, and digestive enzymes could alleviate gastrointestinal symptoms in patients with inflammatory bowel disease (IBD) and concurrent irritable bowel syndrome (IBS).

The study involved 43 patients who were already in clinical remission and treated only with mesalamine. They were divided into two groups: one received the usual treatment plus the supplement, while the other only received the standard care.

After four weeks, we observed notable improvements in symptoms such as bloating, flatulence, and abdominal pain in the group taking the supplement. Our findings suggest that this combination may significantly enhance the overall well-being of IBD-IBS patients, making their daily lives a bit easier.

7.5

Calms anxiety

Most Useful Review

B3 plays a crucial role in metabolising carbohydrates, lipids, and proteins while assisting oxidation in the body. It supports normal nervous system function, calms nerves, alleviates irritability and anxiety, and improves insomnia linked to depression. B3 also aids intestinal digestion and promotes oral, skin, and tongue health, while contributing to hormone synthesis and lowering cholesterol.

Updated: Apr 2025

Kidney Stones details

Inositol shows promise for nephropathies

Based on 3 Researches

Kletzmayr A, Mulay SR, Motrapu M, Luo Z, Anders HJ, et al. Inhibitors of Calcium Oxalate Crystallization for the Treatment of Oxalate Nephropathies. Adv Sci (Weinh). 2020;7:1903337. doi:10.1002/advs.201903337

We explored the potential of inositol hexakisphosphate (IP6) and its analogues as a treatment for calcium oxalate (CaOx) nephropathies, conditions often linked to kidney stones. Our study utilized a new machine learning approach that helped screen various chemical modifications of IP6 to find a particularly effective compound.

This innovative method led us to identify a divalent inositol phosphate that demonstrated remarkable activity. In our findings, this molecule completely inhibited the crystallization of CaOx crystals at very low concentrations. Additionally, it significantly reduced the interaction between crystals and kidney cells, preventing harmful changes in gene expression related to kidney damage.

We observed that, in a mouse model experiencing increased levels of oxalate, the IP6 analogue reduced crystal formation and subsequent kidney injury. With these promising results, we believe that these inositol analogues may offer a new therapeutic option for those suffering from calcium oxalate-related kidney issues.

7.5

Kidney health improved

Most Useful Review

The quality and ingredients are excellent. It helps improve low-density lipoprotein, protects kidney health, and maintains normal metabolism. With 180 capsules in a bottle, it's more than sufficient. My mother has been taking it for a few months and has responded positively. I would definitely consider purchasing it again.

Updated: Apr 2025

Migraine details

Niacin may reduce migraine risk

Based on 2 Researches

Liu H, Wang L, Chen C, Dong Z, Yu S. Association between Dietary Niacin Intake and Migraine among American Adults: National Health and Nutrition Examination Survey. Nutrients. 2022;14. doi:10.3390/nu14153052

We examined the link between dietary niacin intake and migraine occurrences by analyzing data from the National Health and Nutrition Examination Survey. This study focused on adults over 20 years old, looking specifically at their reported experiences with severe headaches and the amount of niacin they consume daily.

Among the 10,246 participants, we found that 20.1% reported having migraines. Those who had a higher intake of niacin showed a lower likelihood of experiencing migraines. For instance, compared to individuals with the lowest niacin intake, those in higher intake categories (Q2, Q3, and Q4) had significantly reduced odds of suffering from migraines. The results indicated that increasing dietary niacin had a favorable effect, suggesting an L-shaped curve relationship where the optimal intake appears to be around 21 mg per day.

This study highlighted a possible connection between niacin consumption and migraine prevention, indicating that moderate levels might play a protective role. However, it’s important to approach these findings cautiously, as they don’t establish cause and effect directly. Further research could illuminate how dietary choices might influence migraine frequency and severity.

7.5

Reduced migraine attacks

Most Useful Review

5 people found this helpful

Vitamin B3, alongside nicotinic acid and nicotinamide, is beneficial for normalising digestion and sleep, and promoting relaxation. It helps prevent migraine attacks and stabilises mood. I take this vitamin at night, alongside L-tryptophan, to enhance these effects.

Updated: Mar 2026

Depression details

Myo-inositol: Depression treatment potential

Based on 4 Researches

Derkaczew M, Martyniuk P, Osowski A, Wojtkiewicz J. Cyclitols: From Basic Understanding to Their Association with Neurodegeneration. Nutrients. 2023;15. doi:10.3390/nu15092029

We explored the potential of inositol, particularly Myo-inositol (MI), as a treatment option for depression, especially in individuals dealing with neurodegenerative disorders. The literature suggests that MI and its derivatives are vital in various cellular functions, including signal transmission and osmoregulation.

While our focus was primarily on neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's, the interesting twist is how inositol may also help alleviate depressive symptoms. Research indicates that dietary supplementation with MI can have promising effects on mental health, suggesting a connection between inositol levels and mood enhancement.

However, despite the encouraging findings, much remains to be discovered. The relationship between inositol treatment and its effectiveness in treating depression is still being closely examined. Overall, it appears that while inositol shows potential, more comprehensive studies are needed to fully understand its benefits and mechanisms related specifically to depression.

Depression remedy

Most Useful Review

1 people found this helpful

Good for depression.

Updated: Mar 2026

High Cholesterol details

IP6 improves cholesterol levels

Based on 10 Researches

Okazaki Y, Katayama T. Dietary inositol hexakisphosphate, but not myo-inositol, clearly improves hypercholesterolemia in rats fed casein-type amino acid mixtures and 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane. Nutr Res. 2008;28:714. doi:10.1016/j.nutres.2008.07.003

We examined the effects of inositol hexakisphosphate (IP6) and myo-inositol on high cholesterol in rats. In our study, we found that dietary IP6 effectively reduced increased cholesterol levels caused by a specific chemical exposure, while myo-inositol did not show significant benefits.

Additionally, IP6 also contributed to body weight gain, regardless of other dietary factors. Overall, while both inositol types helped prevent fatty liver, only IP6 demonstrated a clear advantage in managing hypercholesterolemia.

Enhances concentration

Most Useful Review

11 people found this helpful

I started giving this to my junior high school child, who now completes homework much faster thanks to improved concentration. Although it's combined with other megavitamins, I feel it significantly contributes to better health.

Updated: Mar 2026

Sleep Apnea details

2 people found this helpful

I started taking this for stress-induced sleeplessness. I'm pleased to say it has helped alleviate my heart palpitations and shortness of breath, allowing me to sleep better at night. My overall sense of relief has improved significantly.

Flu details

No flushing side effects

70 people found this helpful

Truly is flush-free! I was prescribed Niacin for cholesterol and this brand is the only one that doesn’t produce the flushing symptoms. Others claimed to be flush-free but weren't. This supplement has helped lower my cholesterol without side effects, and I don’t need prescription meds anymore.

Emotional calmness achieved

Attention Deficit Hyperactivity Disorder details

39 people found this helpful

Niacin for ADHD has been life-changing for me. I can only consume flash-free niacin due to itchiness from the flush type. Taking two tablets daily significantly reduced my ADHD-related impulsivity. By increasing to three tablets, I experienced even greater emotional stability. Since my ADHD diagnosis as an adult, managing anger has been a challenge. However, niacin has made those overwhelming feelings diminish. I stopped taking it for a week and instantly reverted to feeling frustrated. I realised I must consistently take niacin to maintain calmness and emotional control, especially when parenting. It's pivotal for a manageable life. Other supplements I take include B50 and vitamin E. I hope my experience helps others facing similar emotional control challenges, particularly regarding anger.

Blood Clot details

SCI offers safe anticoagulant potential

Likely Very Effective

Al-Horani RA, Abdelfadiel EI, Afosah DK, Morla S, Sistla JC, et al. A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding. J Thromb Haemost. 2019;17:2110. doi:10.1111/jth.14606

We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.

In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.

Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.

Lowers cholesterol

Most Useful Review

8 people found this helpful

No flushing issues; the effect is decent, so I’ll keep taking it. Niacin is known for reducing blood lipids and enhancing good cholesterol while lowering bad cholesterol. My family, who has diabetes, is keen on controlling blood lipids without prescriptions. This product doesn’t cause flushing, and my family feels well after a while, with test results improving. I’ll continue observing the effects!

Updated: Apr 2025

Cold details

Inositol enhances rapeseed cold tolerance

Based on 6 Researches

Yan L, Zeng L, Raza A, Lv Y, Ding X, et al. Inositol Improves Cold Tolerance Through Inhibiting and Increasing Ca Influx in Rapeseed ( L.). Front Plant Sci. 2022;13:775692. doi:10.3389/fpls.2022.775692

We explored the impact of inositol on cold stress in rapeseed, an essential oilseed crop affected by low temperatures. Notably, we found that inositol plays a significant role in enhancing cold tolerance in these plants by boosting calcium ion (Ca) influx.

Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.

Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.

Improved cold hands

Most Useful Review

4 people found this helpful

Regular niacin causes a flush, which I dislike, so I always use flash-free niacin. Although I'm unsure if it's effective since there's no flush, I feel my cold hands and feet have improved. I take one slightly larger capsule every night, but the flash-free version is pricier, which is a bit troublesome.

Updated: Mar 2026

Gout details

Rebixiao granules reduced gout symptoms

Ji W, Zhu XX, Tan WF, Lu Y. Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis. Chin J Integr Med. 2005;11:15.

We observed the effectiveness of Rebixiao granules, which include niacin, in treating patients with repeatedly attacking acute gouty arthritis. In the study, 90 patients were split into two groups. The first group received Rebixiao granule treatment, while the second group was given traditional anti-inflammatory tablets. Both groups also followed standard treatments like dietary changes and hydration.

One interesting aspect was the animal study that involved administering hypoxanthine and niacin to mice. This helped establish a model to see how these treatments affected uric acid levels in the blood. The results showed that Rebixiao granules were effective at reducing blood uric acid and had quicker results than just anti-inflammatory treatments alone. However, while niacin was part of the treatment, the study does not clarify its isolated impact on gout as it was combined with other ingredients.

Overall, we found that Rebixiao granules, possibly aided by niacin, were beneficial for gout patients without significant side effects. This indicates a promising option for managing gout symptoms and preventing future attacks.

7.5

Helps with hormones

Most Useful Review

Niacin, also known as vitamin B3, is a remarkable supplement. I take it during menopause, as it doesn't trigger hot flashes like regular vitamin B3. It aids those with hormone issues, helps with gout, and improves blood microcirculation. I wish you all good health.

Updated: Apr 2025

Diabetes details

Myo-inositol aids gestational diabetes

Based on 10 Researches

Chen H, Xiong J, Li Z, Chen Y, Zhang M, et al. Influence of myo-inositol on metabolic status for gestational diabetes: a meta-analysis of randomized controlled trials. J Matern Fetal Neonatal Med. 2024;37:2228450. doi:10.1080/14767058.2023.2228450

We aimed to evaluate how myo-inositol supplementation affects women with gestational diabetes through a meta-analysis of randomized controlled trials. Our search included multiple databases, leading to the analysis of four studies involving 317 participants. The results showed that myo-inositol significantly reduced the need for insulin and improved insulin sensitivity. However, it did not influence birth weight, cesarean delivery rates, or NICU admissions. These findings suggest myo-inositol could be a helpful addition to managing gestational diabetes, but further research is needed.

Blood sugar concern

Most Useful Review

After I purchased it, I discovered that it raises blood sugar levels. As I have diabetes, I am reluctant to consume it. What a waste.

Updated: Apr 2025

Heart Attack details

ITPP enhances heart attack recovery

Likely Very Effective

Oknińska M, El-Hafny-Rahbi B, Paterek A, Mackiewicz U, Crola-Da Silva C, et al. Treatment of hypoxia-dependent cardiovascular diseases by myo-inositol trispyrophosphate (ITPP)-enhancement of oxygen delivery by red blood cells. J Cell Mol Med. 2020;24:2272. doi:10.1111/jcmm.14909

We explored the potential of myo-inositol trispyrophosphate (ITPP) as a treatment for heart attacks and its effect on heart tissue injured by low oxygen levels. This research indicates ITPP modifies hemoglobin in red blood cells, enhancing the delivery of oxygen throughout the body.

Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.

In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.

Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.

7.5

Clears blood vessels

Most Useful Review

2 people found this helpful

Due to coronary heart disease, I have significant blockages in my blood vessels. I know niacin aids in clearing these, and I've experienced minimal flushes. I trust its quality, and it hasn’t affected my allergies.

Updated: Apr 2025

Liver Disease details