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Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol (from 640 mg of Inositol Hexanicotinate)
135 mg
†
The product is found useful for the following medical conditions
Flu
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 12 Reviews
8.9
9.5
No flushing side effects
Most Useful Review
Truly is flush-free! I was prescribed Niacin for cholesterol and this brand is the only one that doesn’t produce the flushing symptoms. Others claimed to be flush-free but weren't. This supplement has helped lower my cholesterol without side effects, and I don’t need prescription meds anymore.
Back Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.8
9.5
No back pain
Most Useful Review
Very effective! Since I started taking niacin, my long-term back pain has vanished. I can now lie on my back without discomfort throughout the night. My husband, who has also started taking it, experienced significant benefits as well. He was advised to check for potential collagen disease, and since we began this regimen, his symptoms have improved dramatically. We're both committed to using it daily.
Bone Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 12 Reviews
8.8
9.5
Cured back pain
Most Useful Review
Very great! After I started taking niacin for better sleep, my long-standing bone pain disappeared. I often struggled to lie on my back and woke frequently, but now I sleep soundly without discomfort. Notably, my husband began taking it too, and it has significantly aided him in battling his potential collagen disease. I was initially sceptical, but I found the pain eased almost immediately after starting niacin – it’s now essential for both of us.
Allergies
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 16 Reviews
8.7
9.5
Diminished food allergies
Most Useful Review
A niacin deficiency apparently hindered my serotonin production. After supplementation, I noticed improved mental stability and posture. Surprisingly, my food allergies have also improved significantly, and the scratches I used to have on my skin while sleeping have nearly disappeared.
Chest Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.7
8.8
Chest pain gone
Most Useful Review
Very effective! There’s no flushing at all, and my chest pain during physical exertion has disappeared. However, I do wonder if 500mg might be too strong for my liver.
High Cholesterol
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
USERS' SCORE
Good
Based on 71 Reviews
8.7
9
Inositol boosts growth and health
Inositol Inclusion Affects Growth, Body Composition, Antioxidant Performance, and Lipid Metabolism of Largemouth Bass ().
Most Relevant Research
We explored how inositol affects growth performance and cholesterol levels in largemouth bass through a systematic diet study. By preparing six different diets with varying inositol concentrations, we fed the fish for eight weeks and closely monitored their progress. The results showed that our group consuming 250 mg/kg of inositol enjoyed significantly better weight gain, growth rates, and feed efficiency compared to the control group.
Interestingly, as we increased the inositol levels, we noticed a rise in serum triglycerides and cholesterol, particularly peaking in the 250 mg/kg group. It appeared that while inositol helped improve overall growth, it also influenced cholesterol levels in a complex way. However, the high-density lipoprotein cholesterol (HDL-C), often considered "good" cholesterol, remained unaffected across all treatment groups.
Furthermore, our analysis revealed that inositol supplementation not only reduced fat deposition in the liver but also enhanced the fish's antioxidant capacity by lowering harmful enzymes and increasing beneficial antioxidant markers. This suggests that while inositol modified cholesterol dynamics, it also supported the general health and performance of the fish.
Overall, the findings indicate that dietary inositol can significantly improve growth and antioxidant capacity in largemouth bass, with an optimal dosage around 250 mg/kg to harness these benefits effectively.
Interestingly, as we increased the inositol levels, we noticed a rise in serum triglycerides and cholesterol, particularly peaking in the 250 mg/kg group. It appeared that while inositol helped improve overall growth, it also influenced cholesterol levels in a complex way. However, the high-density lipoprotein cholesterol (HDL-C), often considered "good" cholesterol, remained unaffected across all treatment groups.
Furthermore, our analysis revealed that inositol supplementation not only reduced fat deposition in the liver but also enhanced the fish's antioxidant capacity by lowering harmful enzymes and increasing beneficial antioxidant markers. This suggests that while inositol modified cholesterol dynamics, it also supported the general health and performance of the fish.
Overall, the findings indicate that dietary inositol can significantly improve growth and antioxidant capacity in largemouth bass, with an optimal dosage around 250 mg/kg to harness these benefits effectively.
9.5
Reduces back pain
Most Useful Review
This product has been fantastic! Since I began taking niacin for better sleep, my chronic back pain has vanished. I now sleep soundly through the night. My husband, who started taking it too, received alarming news about his potential collagen disease but has shown improvement since we began. Niacin has significantly alleviated our pains.
Knee Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.7
9.5
Knee injury recovery
Most Useful Review
My knee is numb due to an injury, and I'm taking 6g of Niacin daily. I find it greatly helps with recovery and alleviating knee pain. I haven't experienced any side effects, and I intend to continue using it.
Cardiovascular Disease
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 18 Reviews
8.6
9
Inositol protects against cardiac damage
Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice.
Most Relevant Research
We investigated how inositol supplementation could counteract heart issues caused by lithium in mice. Our study involved four groups of mice to explore the varying effects of inositol. One group received lithium alone, another received lithium followed by inositol, a third group had both lithium and inositol from the start, and a control group had no treatment at all.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
9.5
Back pain relief
Most Useful Review
Very good! Since I started taking niacin for better sleep, my long-standing back pain has vanished. Initially, I had trouble lying on my back and woke frequently at night, but now I sleep soundly. My husband, who began taking it too, was informed by his doctor about a potential collagen disease. After extensive research, we decided to supplement with niacin, and the pain nearly disappeared the next day. It’s now essential for both of us.
Depression
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
USERS' SCORE
Good
Based on 18 Reviews
8.6
8
Myo-inositol: Depression treatment potential
Cyclitols: From Basic Understanding to Their Association with Neurodegeneration.
Most Relevant Research
We explored the potential of inositol, particularly Myo-inositol (MI), as a treatment option for depression, especially in individuals dealing with neurodegenerative disorders. The literature suggests that MI and its derivatives are vital in various cellular functions, including signal transmission and osmoregulation.
While our focus was primarily on neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's, the interesting twist is how inositol may also help alleviate depressive symptoms. Research indicates that dietary supplementation with MI can have promising effects on mental health, suggesting a connection between inositol levels and mood enhancement.
However, despite the encouraging findings, much remains to be discovered. The relationship between inositol treatment and its effectiveness in treating depression is still being closely examined. Overall, it appears that while inositol shows potential, more comprehensive studies are needed to fully understand its benefits and mechanisms related specifically to depression.
While our focus was primarily on neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's, the interesting twist is how inositol may also help alleviate depressive symptoms. Research indicates that dietary supplementation with MI can have promising effects on mental health, suggesting a connection between inositol levels and mood enhancement.
However, despite the encouraging findings, much remains to be discovered. The relationship between inositol treatment and its effectiveness in treating depression is still being closely examined. Overall, it appears that while inositol shows potential, more comprehensive studies are needed to fully understand its benefits and mechanisms related specifically to depression.
8.8
Effective treatment
Most Useful Review
It's great for managing depression, and being flush-free makes it even more comfortable to take.
Heart Disease
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 26 Reviews
8.6
8
Inositol boosts heart protective adiponectin
Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin.
Most Relevant Research
Our research focused on understanding how inositol, specifically a molecule called 5-InsP7, plays a role in heart health by influencing levels of a substance called adiponectin. Adiponectin is important because it helps protect against cardiovascular issues and metabolic disorders.
We discovered that the enzyme inositol hexakisphosphate kinase 1 (IP6K1) produces 5-InsP7, which helps regulate how much adiponectin is available in the bloodstream. This regulation occurs through a process that ensures adiponectin stays stable instead of degrading within the cells.
When we decreased the levels of 5-InsP7—either by knocking out the gene responsible for producing it or through specific drug treatments—we noticed a significant increase in adiponectin levels in the plasma. This increase particularly favored the high molecular weight forms of adiponectin, which are particularly beneficial for heart protection.
The findings suggest that targeting 5-InsP7 could be a promising strategy for enhancing adiponectin levels, potentially offering a new avenue for protecting the heart against damage from conditions like ischemia-reperfusion injury, which occurs when blood flow returns to the heart after a period of blockage.
Overall, this study gives insight into how inositol treatment might help heart disease, emphasizing the importance of adiponectin in cardiovascular health.
We discovered that the enzyme inositol hexakisphosphate kinase 1 (IP6K1) produces 5-InsP7, which helps regulate how much adiponectin is available in the bloodstream. This regulation occurs through a process that ensures adiponectin stays stable instead of degrading within the cells.
When we decreased the levels of 5-InsP7—either by knocking out the gene responsible for producing it or through specific drug treatments—we noticed a significant increase in adiponectin levels in the plasma. This increase particularly favored the high molecular weight forms of adiponectin, which are particularly beneficial for heart protection.
The findings suggest that targeting 5-InsP7 could be a promising strategy for enhancing adiponectin levels, potentially offering a new avenue for protecting the heart against damage from conditions like ischemia-reperfusion injury, which occurs when blood flow returns to the heart after a period of blockage.
Overall, this study gives insight into how inositol treatment might help heart disease, emphasizing the importance of adiponectin in cardiovascular health.
9.5
Helps with circulation
Most Useful Review
Niacin is effective for high cholesterol and aids in circulation issues, migraines, and digestive problems. It also assists those seeking to pass drug tests. Niacinamide treats diabetes and skin conditions. It's beneficial for schizophrenia, memory issues, and heart disease, making it a versatile and valuable supplement.
Cold
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.5
USERS' SCORE
Good
Based on 1 Review
8.6
8
Inositol enhances rapeseed cold tolerance
Inositol Improves Cold Tolerance Through Inhibiting and Increasing Ca Influx in Rapeseed ( L.).
Most Relevant Research
We explored the impact of inositol on cold stress in rapeseed, an essential oilseed crop affected by low temperatures. Notably, we found that inositol plays a significant role in enhancing cold tolerance in these plants by boosting calcium ion (Ca) influx.
Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.
Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
Our study involved identifying various genes associated with inositol and analyzing their expression under cold conditions. Interestingly, inositol appeared to inhibit the expression of calcineurin B-like genes, which are involved in regulating calcium flow, suggesting a unique pathway through which inositol aids in cold resilience.
Additionally, when we overexpressed certain genes linked to calcium flux, we noted a stronger response to cold stress, further emphasizing the importance of the inositol-Ca pathway in facilitating cold tolerance in rapeseed. These findings not only deepen our understanding of how rapeseed copes with cold conditions but also present a potential strategy for enhancing crop resilience in the face of climate challenges.
9.5
Quick cold sore relief
Most Useful Review
It works great for fever blisters. I take several during a breakout of cold sores, and it quickly gets rid of them.
Headache
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
No headaches experienced
Most Useful Review
I have not encountered any side effects with this product—no headaches, flushing, or digestive issues. There is some debate about this version of B3, but it works remarkably well for me. Be cautious with dosage, as 500mg is considerable, and consult with your doctor regarding any potential interactions. I have relied on NOW for years and can highly recommend them.
Hot Flashes
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
10
No hot flashes
Most Useful Review
No hot flashes from them. Completely relieved of hot flashes using this product.
Cold Sores
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
9
Improved blood flow
Most Useful Review
I read in a book by an ophthalmologist that niacin is beneficial for those with glaucoma, so I've been taking it regularly. It's brush-free, which prevents sudden warmth, and it's easy to consume. It enhances blood circulation, alleviating my concerns about feeling cold. I plan to continue taking it for some time.
Common Cold
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.5
8.8
No niacin flush
Most Useful Review
Having used niacin for some time, I would experience a flush, leading me to take it at night, but it disrupted my sleep. I tried this flash-free version, and it worked well without causing any flush, allowing me to drink it at any time. It’s ideal for those who suffer from flush.
Cough
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Allergy relief
Most Useful Review
A friend recommended cayenne pepper with flush-free niacin to help my constant allergic cough. It seems to have worked or at least helped considerably.
Anxiety
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.6
USERS' SCORE
Good
Based on 27 Reviews
8.4
8
Inositol reduces anxiety in hens
Dietary Inositol Reduces Fearfulness and Avoidance in Laying Hens.
Most Relevant Research
We conducted a study to understand how inositol, a naturally occurring sugar alcohol, influences anxiety levels in laying hens. Our focus was on the behavior of Lohmann LSL lite hens, which were fed two different diets—one rich and one deficient in protein—while receiving either pure inositol or high levels of phytase.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
9.5
Decreased anxiety
Most Useful Review
I purchased this for a teenager with anxiety. Initially, I was on medication, but I tried niacinamide to reduce my dosage. After three months, I started taking 100mg of niacin, two tablets after meals. I’ve adapted to it, and my anxiety has significantly decreased, allowing me to stop my hospital medication. The niacin seems to work well; I’ll soon try niacin 500mg for future prevention. I’m smiling more and feeling brighter, all without side effects, so I’ll keep using it.
Chronic Cough
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.4
7.5
Notable improvement
Most Useful Review
I’m trying this in higher doses to see if it alleviates my chronic fatigue and pain. So far, I have noticed some improvement.
Neuropathy
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.3
6.3
Blood sugar issues
Most Useful Review
This product significantly aided my neuropathy, but I discovered it can elevate blood sugar levels. After starting this, my blood sugar rose dramatically. Be cautious and research it further.
Gout
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 2 Reviews
8.2
8
Rebixiao granules reduced gout symptoms
Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis.
Most Relevant Research
We observed the effectiveness of Rebixiao granules, which include niacin, in treating patients with repeatedly attacking acute gouty arthritis. In the study, 90 patients were split into two groups. The first group received Rebixiao granule treatment, while the second group was given traditional anti-inflammatory tablets. Both groups also followed standard treatments like dietary changes and hydration.
One interesting aspect was the animal study that involved administering hypoxanthine and niacin to mice. This helped establish a model to see how these treatments affected uric acid levels in the blood. The results showed that Rebixiao granules were effective at reducing blood uric acid and had quicker results than just anti-inflammatory treatments alone. However, while niacin was part of the treatment, the study does not clarify its isolated impact on gout as it was combined with other ingredients.
Overall, we found that Rebixiao granules, possibly aided by niacin, were beneficial for gout patients without significant side effects. This indicates a promising option for managing gout symptoms and preventing future attacks.
One interesting aspect was the animal study that involved administering hypoxanthine and niacin to mice. This helped establish a model to see how these treatments affected uric acid levels in the blood. The results showed that Rebixiao granules were effective at reducing blood uric acid and had quicker results than just anti-inflammatory treatments alone. However, while niacin was part of the treatment, the study does not clarify its isolated impact on gout as it was combined with other ingredients.
Overall, we found that Rebixiao granules, possibly aided by niacin, were beneficial for gout patients without significant side effects. This indicates a promising option for managing gout symptoms and preventing future attacks.
8.8
Helps with hormones
Most Useful Review
Niacin, also known as vitamin B3, is a remarkable supplement. I take it during menopause, as it doesn't trigger hot flashes like regular vitamin B3. It aids those with hormone issues, helps with gout, and improves blood microcirculation. I wish you all good health.
Leg Cramps
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.2
9.5
Pain relief observed
Most Useful Review
Since using this product, I’ve noticed less pain in my legs, and the spider veins are starting to decrease. I’m very satisfied!
Autoimmune Disorder
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
5.6
USERS' SCORE
Good
Based on 18 Reviews
8.1
8
Myo-inositol enhances vitamin D effects
The impact of vitamin D on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in myo-inositol-treated and myo-inositol-naïve women with autoimmune thyroiditis: A pilot study.
Most Relevant Research
Our study aimed to explore the impact of myo-inositol treatment on thyroid autoimmunity in women with autoimmune thyroiditis. We included groups of women who had been on myo-inositol for a while and those who hadn’t. For six months, we observed how vitamin D supplementation interacted with myo-inositol in affecting thyroid health and immune responses.
We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.
Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
We found that among participants taking myo-inositol, the addition of vitamin D significantly improved insulin sensitivity and led to better outcomes regarding thyroid antibodies. Specifically, women who were already on myo-inositol showed a greater reduction in thyroid peroxidase and thyroglobulin antibodies when vitamin D was added to their regimen.
Interestingly, the effects of vitamin D were less noticeable in women who weren't on myo-inositol. These individuals did not exhibit the same improvements in thyroid function or antibodies. Overall, the findings suggest that myo-inositol might enhance the benefits of vitamin D, indicating a potential synergistic effect between these two agents in managing autoimmune thyroiditis.
9.5
Lameness improvement
Most Useful Review
I started taking Niacin Flush for preventive purposes under Dr. Tokumi Fujikawa's approach. I noticed an improvement in blood flow in my right leg; my lameness has improved significantly. Niacin's vasodilatory effects are evident; while results may vary, I believe it is worthwhile.
Heart Attack
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 7 Reviews
8.1
9
ITPP enhances heart attack recovery
Treatment of hypoxia-dependent cardiovascular diseases by myo-inositol trispyrophosphate (ITPP)-enhancement of oxygen delivery by red blood cells.
Most Relevant Research
We explored the potential of myo-inositol trispyrophosphate (ITPP) as a treatment for heart attacks and its effect on heart tissue injured by low oxygen levels. This research indicates ITPP modifies hemoglobin in red blood cells, enhancing the delivery of oxygen throughout the body.
Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.
In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.
Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.
Using an animal model for myocardial infarction, we observed that ITPP administration provided significant protection against heart failure and aided in recovery from left ventricular remodeling following the heart attack.
In our laboratory studies, heart muscle cells exposed to low oxygen levels reacted quickly to ITPP treatment, showing increased activity of a protein known as HIF-1. Interestingly, this overactivity was countered by ITPP when it was in the red blood cells, which suggests a strong connection between shear stress from blood flow and oxygen release facilitated by the modified hemoglobin.
Overall, the findings indicate that ITPP could be a game-changer in treating injuries to heart tissues related to low oxygen or ischemia. This approach may open new avenues for effectively managing damage caused by heart attacks.
8.8
Clears blood vessels
Most Useful Review
Due to coronary heart disease, I have significant blockages in my blood vessels. I know niacin aids in clearing these, and I've experienced minimal flushes. I trust its quality, and it hasn’t affected my allergies.
Blood Clot
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 4 Reviews
8
9
SCI offers safe anticoagulant potential
A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding.
Most Relevant Research
We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
9
Lowers cholesterol
Most Useful Review
No flushing issues; the effect is decent, so I’ll keep taking it. Niacin is known for reducing blood lipids and enhancing good cholesterol while lowering bad cholesterol. My family, who has diabetes, is keen on controlling blood lipids without prescriptions. This product doesn’t cause flushing, and my family feels well after a while, with test results improving. I’ll continue observing the effects!
Sleep Apnea
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.9
9.5
Reduced stress
Most Useful Review
I started taking this for stress-induced sleeplessness. I'm pleased to say it has helped alleviate my heart palpitations and shortness of breath, allowing me to sleep better at night. My overall sense of relief has improved significantly.
Food Poisoning
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
0
Dangerous supplement
Most Useful Review
I experienced insulin resistance and liver toxicity after taking this supplement. My HbA1c rose from 5.5 to 6.3, signalling prediabetes, and my fasting blood sugar jumped from 86 to 127 in just a few months. I also felt nauseous, tired, and unwell after use. This product is awful and dangerous, with such a high dosage that a clear warning should be provided. While I appreciate NOW Foods and most of their products, this one is not suitable at all.
Liver Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.6
8
Myo-inositol improves insulin resistance
The effect of myo-inositol supplementation on AMPK/PI3K/AKT pathway and insulin resistance in patients with NAFLD.
Most Relevant Research
We conducted a double-blinded, placebo-controlled clinical trial to explore how myo-inositol (MI) influences insulin resistance (IR) among obese individuals with non-alcoholic fatty liver disease (NAFLD). Our study involved 48 participants who were randomly assigned to receive either 4 grams of MI or a placebo daily for eight weeks.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
8.3
Helpful symptoms improvement
Most Useful Review
Helpful for my disease symptoms. There is no flushing or itching, and as my doctor says, it significantly aids in alleviating my liver disease symptoms.
