Solgar Calcium Magnesium Plus Zinc

Zinc benefits heart health post-cisplatin

Based on 7 Researches

Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats.

Most Relevant Research

We explored the potential benefits of zinc oxide nanoparticles (ZnONPs) in preventing heart damage caused by cisplatin, a powerful chemotherapy drug known for its efficacy but also for its side effects, particularly cardiotoxicity.

In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.

As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.

Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.

9.5

Reduced cramps

Most Useful Review

This complex is among the best calcium preparations due to its chelated form, ensuring maximum absorption. Calcium strengthens bones, magnesium aids its distribution, and zinc supports collagen production. After using this for my parents, my father's arm cramps post-heart attack ceased, and my mother no longer suffers from leg cramps at night. Remember to take Vitamin D for better calcium absorption.

Knee Pain details

Calcium injection aids knee function

Questionable

Based on 2 Researches

Total Knee Conversion Rates and Functional Outcome After Calcium Phosphate Injection for Bone Marrow Lesions of the Knee.

Most Relevant Research

We explored how calcium phosphate (CaP) injections impact knee pain, particularly in patients suffering from osteoarthritis-related bone marrow lesions (OA-BML). In this study, we compared two groups of patients: those who received knee arthroscopy combined with CaP injections and those who had knee arthroscopy for different knee issues.

Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.

Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.

9.5

No leg pain

Most Useful Review

I no longer feel pain in my legs.

Sleep Apnea details

Zinc protects heart function in OSA

Based on 2 Researches

Zinc Is Indispensable in Exercise-Induced Cardioprotection against Intermittent Hypoxia-Induced Left Ventricular Function Impairment in Rats.

Most Relevant Research

We explored how zinc affects heart function in the context of obstructive sleep apnea (OSA), specifically focusing on cases of intermittent hypoxia (IH). In a detailed study using male rats, researchers set up different groups: a control group and one that underwent 10 weeks of exercise training. Half of the rats in both groups were exposed to IH conditions to simulate the effects of sleep apnea.

The results were eye-opening. Rats that experienced IH showed notable impairment in their heart's left ventricular function, characterized by reduced ejection fraction and increased inflammation. However, when treated with zinc, these negative effects were significantly countered. Notably, those who exercised and received zinc treatment displayed improved heart function and antioxidant capabilities compared to their counterparts that did not receive zinc.

On the flip side, exercise alone did not provide the same protective benefits when zinc was absent. The findings suggest that zinc is essential not only for the heart's protection against the damaging effects of IH but also enhances the benefits of physical exercise. This research indicates the importance of zinc in potentially managing heart health in individuals suffering from sleep apnea.

9.5

Heart pain relief

Most Useful Review

Super! I have a small child and suffered from sleep deprivation, which caused my heart to ache. After visiting a cardiologist, he recommended Calcium, Magnesium, and Zinc. Since I started taking these supplements, my heart no longer hurts. I highly recommend this preparation, although it can be hard to find.

Heart Attack details

Magnesium implantation improves heart recovery

Based on 24 Researches

Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats.

Most Relevant Research

We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.

Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.

Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.

9.5

Heart pain relief

Most Useful Review

Super! I have a small child, and with sleepless nights, my heart ached from fatigue. After consulting a cardiologist, I began taking Calcium, Magnesium, and Zinc, which stopped my heart from hurting. I highly recommend this preparation, though it can be hard to find; I will purchase it again.

Anxiety details

Zinc may alleviate anxiety symptoms

Based on 21 Researches

A systematic review of the association between zinc and anxiety.

Most Relevant Research

We explored the connection between zinc intake and anxiety in adults through a systematic review of nine original studies. Two of these studies looked at how zinc consumption impacts anxiety, while the other seven focused on the relationship between serum zinc levels and anxiety symptoms. Our analysis included studies published in English within peer-reviewed journals, ensuring a solid foundation for understanding this potential link.

What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.

In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.

Feeling happier

Most Useful Review

Absolutely amazing. I ordered this product for anxiety, and it is simply remarkable. I've been using it for two weeks now and couldn't be happier.

Headache details

Zinc reduces migraine symptoms

Based on 16 Researches

Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women.

Most Relevant Research

We conducted a randomized, double-blind, placebo-controlled trial to explore how zinc gluconate affects migraine symptoms in women. Sixty participants, with an average age of 35, were given either 15 mg of zinc per day or a placebo for 12 weeks, allowing us to measure the impact on headache frequency, duration, and intensity.

The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.

Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.

In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.

9.5

Headache frequency

Most Useful Review

I’ve had numerous headaches since middle school—migraines, tension, and a Thunder Clap headache a few times. After taking these three a day, my headaches are much less frequent, and my body absorbs this pill much better than others. It has truly helped!

Migraine details

Magnesium reduces migraine symptoms

Based on 23 Researches

Magnesium and Migraine.

Most Relevant Research

We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.

Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.

We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.

9.5

Significantly reduced headaches

Most Useful Review

I've suffered from many types of headaches, including migraines and tension headaches, since middle school. After taking these supplements (3 a day), my headaches have become much less frequent. My body seems to absorb this formulation far better than others, leading to a notable improvement!

Reflux details

Calcium's role in reflux protection

Based on 2 Researches

A combination of carbonates and Opuntia ficus-indica extract protects esophageal cells against simulated acidic and non-acidic reflux in vitro.

Most Relevant Research

We examined a combination product of carbonate antacids—specifically calcium carbonate and magnesium carbonate—with an extract from Opuntia ficus-indica, commonly known as prickly pear. This study looked at how this product could potentially protect esophageal cells from damage caused by both acidic and non-acidic reflux.

Through a series of laboratory tests, we aimed to understand the effectiveness of the product in two ways: neutralizing stomach acid and protecting esophageal cells. The carbonate ingredients showed promising results in neutralizing acidity, which is a common complaint for those suffering from heartburn. However, while calcium’s role in this combination is significant, it isn't isolated; the extract from prickly pear also plays a crucial role in lowering inflammation triggered by bile acids.

Ultimately, we found that the combination product provided dual benefits, helping cells withstand both acidic conditions and irritation from bile acids. Yet, it's essential to note that we could not determine the isolated impact of calcium on reflux, as it works in tandem with other active ingredients. This insight encourages further exploration into the specific effects of calcium in reflux management.

9.5

Less anxious

Most Useful Review

Two a day keeps the doctor away! Following an old pharmacist's advice, I take two tablets daily—one in the morning and one in the evening. I am much less anxious, and my bowel movements are regular. I used to experience bouts of acid reflux and sour stomach, but not anymore.

Food Poisoning details

Zinc oxide combats foodborne pathogens

Based on 6 Researches

Active Packaging of Immobilized Zinc Oxide Nanoparticles Controls Campylobacter jejuni in Raw Chicken Meat.

Most Relevant Research

We set out to explore how zinc oxide nanoparticles (ZnO NPs) could help control the bacteria responsible for food poisoning in raw chicken meat. Our approach involved integrating these nanoparticles into packaging materials to see if they could effectively inactivate Campylobacter jejuni, a common and concerning pathogen in poultry.

Through our experiments, we discovered that immobilizing ZnO NPs in functional pads placed under raw chicken could dramatically reduce bacterial counts. In fact, we saw a reduction from about 4 log CFU to an undetectable level within just three days when storing chicken at 4°C. Notably, we monitored zinc levels in the chicken meat, confirming a safe release of zinc without any migration of nanoparticles onto the food. This means that we can help keep raw chicken safe and fresh without compromising its integrity or quality.

Not only did we find that these functional pads inactivated the harmful bacteria, but we also noted a related increase in lactic acid production, which plays a role in further protecting the meat. Our findings open up new avenues for using zinc in food packaging, offering a way to enhance food safety without directly adding chemicals to the food itself. Overall, this study highlights the potential for nanotechnology to play a significant role in managing foodborne pathogens like Campylobacter in poultry products.

8.3

Relieved muscle cramps

Most Useful Review

Purchasing from iHerb saved me 50%. This bottle of supplements costs twice as much at my local health food shop. Since taking CM+Z every morning, my evening leg muscle cramps have been alleviated, which helps me avoid instances of food poisoning.

Osteoporosis details

Magnesium's role in osteoporosis therapy

Based on 27 Researches

Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism.

Most Relevant Research

We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.

Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.

In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.

Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.

9.5

Cramps alleviated

Most Useful Review

I ordered this for my husband and now our whole family enjoys it. He had concerns about leg cramps, but after more than a month on the supplement, the cramps have ceased. I also began taking calcium, magnesium, and zinc to prevent osteoporosis. The dosage is appropriate, and the large packaging lasts a long time.

Kidney Stones details

Magnesium reduces kidney stone risk

Based on 17 Researches

Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial.

Most Relevant Research

We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.

After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.

Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.

8.8

Prevents recurrence

Most Useful Review

My favourite Ca Mg Zn tablets. The Solgar Calcium Magnesium Plus Zinc tablets are my preferred choice as they come in a glass jar and provide the necessary amounts of Ca and Mg to help prevent kidney stones (familial hyperoxaluria). The Zn also supports my immune system; since I began taking these daily, I've been less prone to colds unless I forget to reorder in time.

Back Pain details

Magnesium reduces postoperative back pain

Based on 9 Researches

Effect of perioperative intravenous magnesium sulfate on postoperative pain after iliac venous stenting.

Most Relevant Research

We explored the effectiveness of magnesium sulfate (MS) in relieving low back pain (LBP) for patients who underwent iliac venous stenting. This study involved 97 patients, divided into two groups: one received MS infusion during their surgery, while the other did not.

Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.

Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.

9.5

Joint and muscle relief

Most Useful Review

The composition is excellent, with noticeably better quality than others. The capsules are of manageable size, with optimal dosages of calcium, magnesium, and zinc. After a week, my joint pain, muscle cramps, and sleep issues improved significantly.

Chest Pain details

Zinc treatment for angina pectoris

Based on 10 Researches

High-dose zinc to terminate angina pectoris: a review and hypothesis for action by ICAM inhibition.

Most Relevant Research

We delved into an intriguing question: Can high doses of zinc help relieve chest pain caused by angina pectoris? Our research reviewed studies that highlight how zinc may play a role in managing this condition. Angina pectoris often results from arteriosclerosis, where the arteries become narrowed due to cholesterol buildup and other factors.

We discovered that patients with severe atherosclerosis showed promising improvements when treated with high-dose zinc. Specifically, a treatment regimen involved raising serum zinc levels significantly, resulting in symptom relief for many individuals. In one notable case, 12 out of 16 patients experienced measurable benefits, including one patient who also suffered from Raynaud's disease.

Furthermore, our analysis noted that long-term exposure to zinc in the environment correlated with reduced incidence of angina and ischemic events during exercise. Zinc appears to possess antioxidant properties, which may protect against the oxidation of LDL cholesterol, a key player in artery damage. By blocking certain inflammatory factors and promoting better circulation, zinc might enhance heart function and alleviate chest pain.

Based on these findings, we propose that zinc treatment should be considered a fundamental option in both prevention and therapy for atherosclerosis-related chest pain. This could lead to a renewed focus on restoring a healthier cardiac function among those affected by these conditions.

8.3

Relief from pain

Most Useful Review

I feel relieved from back pain! After taking this, I am very comfortable.

Insomnia details

Magnesium improves elderly insomnia

Based on 14 Researches

The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.

Most Relevant Research

We conducted a double-blind, placebo-controlled clinical trial to investigate the effects of magnesium supplementation on insomnia in elderly individuals. Our study involved 46 participants who were assigned either to receive 500 mg of magnesium daily or a placebo for a duration of 8 weeks.

Throughout the study, we employed various questionnaires, including the Insomnia Severity Index (ISI), to evaluate the participants' sleep quality both before and after the treatment period. We also monitored the intake of other nutrients and performed blood tests to assess hormone levels related to sleep.

The results showed that magnesium supplementation led to significant improvements in areas such as sleep efficiency, sleep onset timing, and overall insomnia severity. We observed increases in serum levels of melatonin and changes in cortisol and renin levels, indicating a physiological response that could enhance sleep quality.

Overall, it seems that supplementing with magnesium has the potential to improve sleep for older adults struggling with insomnia. This finding could pave the way for new, accessible treatment options for those affected by sleep disorders.

6.8

Better magnesium needed

Most Useful Review

Good product, but I wish it contained a different form of magnesium. These tablets are large but easy to chew if you're having trouble swallowing large ones. I bought them primarily for magnesium, hoping it would help with my insomnia. I rate it four stars because the Magnesium Oxide may be less digestible than other forms. Also, one of the other forms, Magnesium citrate, might cause gas, which I like to avoid. Experts recommend Magnesium glycinate as a more effective option.

Leg Cramps details

Magnesium oxide treats leg cramps

Questionable

Based on 24 Researches

A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.

Most Relevant Research

We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.

Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.

The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.

9.5

Helps significantly

Most Useful Review

Great product. It genuinely assists with my leg cramps.

Diarrhea details