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Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
The product is found useful for the following medical conditions
Kidney Stones
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.3
USERS' SCORE
Good
Based on 14 Reviews
8.7
9
Magnesium reduces kidney stone risk
Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial.
Most Relevant Research
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.
After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.
Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.
Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
10
Doctor's recommendation
Most Useful Review
Excellent for kidney stone prevention! My urologist recommended these tablets, citing studies that show B6 and Magnesium can prevent kidney stones in women. I’ve been taking them for 2-3 years, and they are absolutely fantastic! Although the recommended dosage is three tablets daily, I take only two, one in the morning and one in the evening with meals, and I haven’t had any issues with new stones.
Anxiety
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.1
USERS' SCORE
Good
Based on 11 Reviews
8.6
9
Vitamin B6 treatment alleviates anxiety
Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring.
Most Relevant Research
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
8.8
Normalised blood pressure
Most Useful Review
Magnesium B6 was prescribed by a neurologist for my mother to combat stress. After just two months, she became calm, positive, and the pressure stabilised. This supplement helped eliminate anxiety and insomnia, normalising her condition without needing additional medications. Cardiologists suggest a daily intake of 400-600 mg of magnesium, which I found beneficial for managing hypertension.
Cancer
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.1
USERS' SCORE
Good
Based on 1 Review
8.6
9
Vitamin B6 pathway affects cancer survival
Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures.
Most Relevant Research
We explored the role of the vitamin B6 pathway in glioblastoma, a particularly aggressive form of brain cancer. Through a detailed analysis involving various cell cultures, we noted significant changes in vitamin B6-related metabolites when comparing 3D spheroid cultures to traditional 2D monolayers.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
9.5
Chemo support product
Most Useful Review
Excellent for alleviating chemotherapy side effects! Chemotherapy can cause varied side effects, including constipation. Despite a healthy diet, my husband, a cancer patient, still faced constipation issues. Laxatives are often chemical-laden and slow to work. These magnesium tablets helped him regain regularity within days. They also contain B6, crucial for nutrient absorption. I've started taking them too, and my frequent leg cramps have vanished. A perfect product for older adults, being small and easy to swallow.
Carpal Tunnel Syndrome
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 1 Review
8.6
7
Magnesium shows mixed effectiveness
Alternative treatment of the carpal tunnel syndrome.
Most Relevant Research
We explored the effects of a combined infusion therapy including magnesium on carpal tunnel syndrome (CTS) in a group of 101 patients who physically worked with their hands. The study utilized a retrospective design, looking back at participants who presented with abnormal nerve function shown through electromyography (EMG).
Within the study, we discovered that the patients' work environments varied widely, with many exposed to hazardous conditions like excessive vibrations. After treatment, 144 out of 166 diagnosed CTS cases showed improvement, suggesting that the combination therapy—including magnesium—could be beneficial for some patients.
When examining specific outcomes based on the severity of CTS, we noticed that patients with mild symptoms improved by an average of 61%, while those with moderate and severe conditions improved by 47% and 50% respectively. Despite these findings, we need to acknowledge that there was no significant difference in treatment outcomes related to age, sex, or symptom severity.
Interestingly, the results highlighted a portion of patients who did not improve or even experienced worsening symptoms. This raises questions about the effectiveness of magnesium and the combined treatment approach. Therefore, while magnesium plays a role in managing CTS for some individuals, it does not guarantee success for everyone.
Within the study, we discovered that the patients' work environments varied widely, with many exposed to hazardous conditions like excessive vibrations. After treatment, 144 out of 166 diagnosed CTS cases showed improvement, suggesting that the combination therapy—including magnesium—could be beneficial for some patients.
When examining specific outcomes based on the severity of CTS, we noticed that patients with mild symptoms improved by an average of 61%, while those with moderate and severe conditions improved by 47% and 50% respectively. Despite these findings, we need to acknowledge that there was no significant difference in treatment outcomes related to age, sex, or symptom severity.
Interestingly, the results highlighted a portion of patients who did not improve or even experienced worsening symptoms. This raises questions about the effectiveness of magnesium and the combined treatment approach. Therefore, while magnesium plays a role in managing CTS for some individuals, it does not guarantee success for everyone.
9.5
Promising improvement
Most Useful Review
Excellent supplement! I began taking this after reading it was beneficial for carpal tunnel syndrome. I must say, my hands have improved since using this. I take several supplements due to having RA, but this one has significantly made a difference for me. I highly recommend it!
Chemotherapy
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 1 Review
8.6
7
Vitamin B6 may reduce CIPN severity
Vitamin B6 status and chronic chemotherapy-induced peripheral neuropathy: a prospective cohort study among patients with non-metastatic colorectal cancer receiving oxaliplatin-based chemotherapy.
Most Relevant Research
We investigated the relationship between vitamin B6 levels and chronic chemotherapy-induced peripheral neuropathy (CIPN) in patients undergoing oxaliplatin-based treatment for non-metastatic colorectal cancer. This study included 242 participants, and we gathered blood samples from them before they started chemotherapy, and then again six and twelve months later.
Our goal was to understand how different vitamin B6 markers, such as pyridoxal 5'-phosphate, relate to the development and severity of CIPN, a common side effect of chemotherapy that can significantly impact quality of life. After analyzing the data, we found that patients with higher levels of vitamin B6 during their chemotherapy were less likely to suffer from chronic CIPN and its associated severity, as compared to those with lower levels.
This suggests that maintaining an optimal vitamin B6 status during treatment could be beneficial for reducing nerve damage caused by chemotherapy. However, further research is needed to confirm these findings and explore how vitamin B6 could be best utilized in cancer treatment settings.
Our goal was to understand how different vitamin B6 markers, such as pyridoxal 5'-phosphate, relate to the development and severity of CIPN, a common side effect of chemotherapy that can significantly impact quality of life. After analyzing the data, we found that patients with higher levels of vitamin B6 during their chemotherapy were less likely to suffer from chronic CIPN and its associated severity, as compared to those with lower levels.
This suggests that maintaining an optimal vitamin B6 status during treatment could be beneficial for reducing nerve damage caused by chemotherapy. However, further research is needed to confirm these findings and explore how vitamin B6 could be best utilized in cancer treatment settings.
9.5
Alleviates constipation
Most Useful Review
For constipation, leg cramps, and healthy bone building, this is a great supplement to ease the side effects of chemotherapy! Chemotherapy causes various side effects, with constipation being one of them. My husband, a cancer patient, experienced binding despite maintaining a healthy diet. Laxatives are chemical-laden and often take days to work. Instead, he took these supplements and became “regular” within days. The chemo depletes essential vitamins, so the B6 combined with magnesium ensures maximum absorption. I also take them now, and my usual leg cramps have disappeared. Many people lack enough magnesium in their diet, crucial for bone production. This product is particularly beneficial for older individuals. The tablets are small, easy to swallow, and smooth, making them quite tolerable.
Diarrhea
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.4
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Magnesium shows potential for diarrhea
Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells.
Most Relevant Research
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
9.5
No side effects
Most Useful Review
No gastrointestinal side effects. With this Magnesium Oxide supplement by Solgar, I benefit from magnesium without the malabsorption issues suffered with other brands. Other supplements caused bloating, gas, stomach pain, and diarrhea, but I have had none of those with Solgar. It's helped reduce my muscle and nerve pain, and I enjoy much more restful sleep. Having taken Magnesium Oxide for over 7 years for my sciatica pain, it keeps the pain at bay, which was previously unbearable. The dosage of three pills allows me to take one every eight hours, and I feel great!
Leg Cramps
SCIENTIFIC SCORE
Likely Ineffective
Based on 16 Researches
4.7
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Magnesium oxide treats leg cramps
A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
Most Relevant Research
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
9.5
Significantly reduces
Most Useful Review
Magnesium can decrease or stop leg cramps and spasms. I use magnesium for both leg cramps and tight muscles. The Solgar Magnesium with Vitamin B6 tablets significantly reduces my leg spasms, so most days I experience none. Magnesium is vital for muscle and nerve function and is essential for muscle relaxation. I’ve tried other brands, but Solgar seems to be the most effective for me.
Bloating
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.4
USERS' SCORE
Good
Based on 1 Review
8.5
8
Magnesium alleviates menstrual bloating
Magnesium supplementation alleviates premenstrual symptoms of fluid retention.
Most Relevant Research
We explored the impact of magnesium supplementation on bloating as part of a larger study examining premenstrual symptoms. In our randomized, double-blind, placebo-controlled design, we administered a daily dose of 200 mg of magnesium (as MgO) to participants over the course of two menstrual cycles. Each volunteer kept track of their symptoms using a detailed diary with twenty-two items.
Initially, we found no difference in premenstrual symptoms between the magnesium and placebo groups during the first month. However, during the second month, participants taking magnesium experienced a notable decrease in bloating and hydration-related symptoms such as weight gain and breast tenderness. This reduction in symptoms was statistically significant, indicating that magnesium can indeed alleviate certain premenstrual symptoms like bloating.
Our findings suggest that magnesium supplementation, particularly in the context of fluid retention and bloating, could be beneficial for women experiencing these discomforts during their menstrual cycle. Overall, this study opens the door to considering magnesium as an effective remedy for mild premenstrual bloating.
Initially, we found no difference in premenstrual symptoms between the magnesium and placebo groups during the first month. However, during the second month, participants taking magnesium experienced a notable decrease in bloating and hydration-related symptoms such as weight gain and breast tenderness. This reduction in symptoms was statistically significant, indicating that magnesium can indeed alleviate certain premenstrual symptoms like bloating.
Our findings suggest that magnesium supplementation, particularly in the context of fluid retention and bloating, could be beneficial for women experiencing these discomforts during their menstrual cycle. Overall, this study opens the door to considering magnesium as an effective remedy for mild premenstrual bloating.
8.8
No side effects
Most Useful Review
No Gastrointestinal Side Effects. With this Magnesium Oxide supplement from Solgar, you gain the benefits of Magnesium without the side effects like bloating and gas that other brands cause. I've experienced none at all with Solgar. Instead, I've had less muscle and nerve pain and improved sleep.
Constipation
SCIENTIFIC SCORE
Questionable
Based on 13 Researches
6.8
USERS' SCORE
Good
Based on 32 Reviews
8.1
4
Effectiveness of magnesium on constipation
Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study.
Most Relevant Research
We explored how changing the frequency of magnesium oxide (MgO) doses influences its effectiveness in relieving constipation. In this study, we looked at 11 patients who had been regularly using MgO to manage their bowel movements and decided to reduce their daily dose frequency over two weeks.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
9.5
Constipation relief
Most Useful Review
After starting magnesium, I felt an improvement in my well-being. I even mixed it with my child's water, and she, too, experienced relief from constipation the same day! I hesitated to add nutrients to my diet, but I want to continue with this supplement.
Headache
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
USERS' SCORE
Moderately Good
Based on 45 Reviews
7.8
9
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
9.5
Reduced headache symptoms
Most Useful Review
I purchased this to alleviate PMS symptoms, and it has genuinely helped. I no longer experience headaches related to PMS, and my symptoms have diminished. I would recommend it if PMS affects you.
