Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
The product is found useful for the following medical conditions
Anemia details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.7
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
We observed a compelling case involving a 32-year-old pregnant woman who experienced severe anemia during her pregnancy. This specific type of anemia, known as sideroblastic anemia, is quite rare in expectant mothers. The patient had been feeling weak and had heart palpitations for two weeks when she came to the emergency room.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
9
Anemia resolved
Most Useful Review
B6 is very reasonably priced; you won't find a smaller jar of Solgar for less than 2000 rubles. During use, my muscle weakness disappeared, and the dizziness when standing up abruptly has gone — the anemia is no longer an issue.
Updated: Mar 2026
Bruise details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Magnesium reduces bruising post-surgery
We explored the impact of magnesium sulfate (MgSO4) wet dressings on bruising and swelling following blepharoplasty, a common eyelid surgery. In our study, fifty-eight patients were evenly split between two treatments: one side received a magnesium sulfate solution, while the other was cooled with ice packs. This setup allowed us to compare the effectiveness of these two methods objectively.
Over the recovery period, we observed that the eyelid swelling was similar in both groups initially but notably reduced over time. However, by the fifth day after surgery, we found that those treated with the magnesium solution experienced significantly less swelling compared to the cooling method. Additionally, bruising—measured by both area and incidence—was also lower in the magnesium group, highlighting its effectiveness.
Interestingly, a significant majority of patients preferred the magnesium treatment over ice cooling, with many appreciating the convenience and results of the wet dressing. This suggests that magnesium sulfate is not only effective in reducing bruising and swelling but is also a patient-favored option for recovery after eyelid surgery.
Over the recovery period, we observed that the eyelid swelling was similar in both groups initially but notably reduced over time. However, by the fifth day after surgery, we found that those treated with the magnesium solution experienced significantly less swelling compared to the cooling method. Additionally, bruising—measured by both area and incidence—was also lower in the magnesium group, highlighting its effectiveness.
Interestingly, a significant majority of patients preferred the magnesium treatment over ice cooling, with many appreciating the convenience and results of the wet dressing. This suggests that magnesium sulfate is not only effective in reducing bruising and swelling but is also a patient-favored option for recovery after eyelid surgery.
9
Life improved greatly
Most Useful Review
I suffer from VVD, and due to a lack of magnesium B6, I experienced issues such as dizziness, palpitations, and bruises under my eyes. Since taking magnesium B6, my life has significantly improved, almost all symptoms have vanished, and I feel rejuvenated! I take 3-4 tablets an hour before bed, leading to restful sleep. This product is a great value with a pure composition, and this brand has proven to be one of the best!
Updated: Mar 2026
Heartburn details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
We explored the impact of a new treatment, Marial®, on patients suffering from gastroesophageal reflux disease (GERD). In a large survey involving 56 gastroenterological offices across Italy, patients were treated with either proton pump inhibitors (PPIs), a combination of PPIs and an additional remedy, or the Marial® formulation containing magnesium alginate. The results showed that both Marial® and the combination therapy significantly reduced heartburn symptoms, with Marial® proving to be more effective than the combination. Overall, patients reported a marked improvement in their GERD-related symptoms.
9
No heartburn issues
Most Useful Review
Excellent quality! I have used this for a long time and it surpasses local alternatives. Importantly, it does not induce heartburn. The packaging was secure, arriving intact. I highly recommend it.
Updated: Mar 2026
Insomnia details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.5
USERS' SCORE
Good
Based on 18 Reviews
8.6
9
We conducted a double-blind, placebo-controlled clinical trial to investigate the effects of magnesium supplementation on insomnia in elderly individuals. Our study involved 46 participants who were assigned either to receive 500 mg of magnesium daily or a placebo for a duration of 8 weeks.
Throughout the study, we employed various questionnaires, including the Insomnia Severity Index (ISI), to evaluate the participants' sleep quality both before and after the treatment period. We also monitored the intake of other nutrients and performed blood tests to assess hormone levels related to sleep.
The results showed that magnesium supplementation led to significant improvements in areas such as sleep efficiency, sleep onset timing, and overall insomnia severity. We observed increases in serum levels of melatonin and changes in cortisol and renin levels, indicating a physiological response that could enhance sleep quality.
Overall, it seems that supplementing with magnesium has the potential to improve sleep for older adults struggling with insomnia. This finding could pave the way for new, accessible treatment options for those affected by sleep disorders.
Throughout the study, we employed various questionnaires, including the Insomnia Severity Index (ISI), to evaluate the participants' sleep quality both before and after the treatment period. We also monitored the intake of other nutrients and performed blood tests to assess hormone levels related to sleep.
The results showed that magnesium supplementation led to significant improvements in areas such as sleep efficiency, sleep onset timing, and overall insomnia severity. We observed increases in serum levels of melatonin and changes in cortisol and renin levels, indicating a physiological response that could enhance sleep quality.
Overall, it seems that supplementing with magnesium has the potential to improve sleep for older adults struggling with insomnia. This finding could pave the way for new, accessible treatment options for those affected by sleep disorders.
9
Effective for insomnia
Most Useful Review
284 people found this helpful
This is a great nutritional supplement that effectively soothes my nerves. After several days of taking it, I completely forgot about my insomnia.
Updated: Mar 2026
Atrial Flutter details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.1
USERS' SCORE
Good
Based on 7 Reviews
8.5
8
Magnesium enhances ibutilide for TAF
We explored how magnesium sulfate influences ibutilide's effectiveness in converting atrial flutter. This randomized, placebo-controlled study included 117 patients with typical (TAF) or atypical atrial flutter (AAF).
Results showed that magnesium significantly enhanced conversion rates in TAF patients—85% with magnesium compared to 59% with placebo. However, for AAF patients, the difference was not significant, with conversion rates at 48% versus 56%. Importantly, magnesium did not impact QT interval durations.
Results showed that magnesium significantly enhanced conversion rates in TAF patients—85% with magnesium compared to 59% with placebo. However, for AAF patients, the difference was not significant, with conversion rates at 48% versus 56%. Importantly, magnesium did not impact QT interval durations.
9
Atrial flutter improved
Most Useful Review
41 people found this helpful
The increased irritability and cardiac arrhythmia have vanished, sleep has improved, and the results regarding my gastrointestinal tract are excellent. At 45, I noticed irritability, restless sleep, and heart arrhythmia, especially when lying down, making it difficult to sleep and causing further annoyance. I have experienced chronic stress lately, and remedies like Valerian and Motherwort ceased to help. Conclusively, I realised a magnesium deficiency was evident in my body and began taking 1 tablet, three times daily with meals. I felt the antidepressant effect of magnesium oxide after three days! My world brightened, and I became calm. By the fifth day, the arrhythmia bothered me significantly less, which delighted me. Additionally, a slight laxative effect occurred, improving my comfort. Critics of this drug exist, but it worked wonders for me!
Updated: Mar 2026
Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.1
USERS' SCORE
Good
Based on 4 Reviews
8.5
9
We explored the role of the vitamin B6 pathway in glioblastoma, a particularly aggressive form of brain cancer. Through a detailed analysis involving various cell cultures, we noted significant changes in vitamin B6-related metabolites when comparing 3D spheroid cultures to traditional 2D monolayers.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
9
Chemo support product
Most Useful Review
32 people found this helpful
Excellent for alleviating chemotherapy side effects! Chemotherapy can cause varied side effects, including constipation. Despite a healthy diet, my husband, a cancer patient, still faced constipation issues. Laxatives are often chemical-laden and slow to work. These magnesium tablets helped him regain regularity within days. They also contain B6, crucial for nutrient absorption. I've started taking them too, and my frequent leg cramps have vanished. A perfect product for older adults, being small and easy to swallow.
Updated: Apr 2025
Cardiovascular Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.5
8
Magnesium's impact on heart health
We examined the connection between dietary magnesium and cardiovascular disease, focusing on how magnesium intake or serum levels relate to heart health. Over the last couple of decades, numerous studies have shown that low magnesium levels are associated with several heart-related issues, including high blood pressure, heart attacks, and even heart failure.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
9
Enhances cardiovascular activity
Most Useful Review
Perfect product! I recommend it heartily! I've been using it for years. It was recommended by my therapist to boost cardiovascular activity and strengthen the nervous and muscular systems. It aids in calcium absorption and supports healthy bone growth and mineralisation.
Updated: Mar 2026
Common Cold details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Calmer sleep
Most Useful Review
Excellent magnesium. The brand is well-known and reliable. The effect is noticeable; convulsions became less common after a week of taking it, and my sleep improved. A truly commendable product.
Updated: Apr 2025
Hypertension details
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
We explored the connection between dietary magnesium intake and hypertension along with other health issues in US adults. In our study, we analyzed data from over 24,000 people, taking into account various lifestyle factors.
We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.
These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.
We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.
These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.
9
Supports hypertension management
Most Useful Review
My excellent husband has hypertension, and I've found this beneficial for his condition.
Updated: Mar 2026
Migraine details
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.4
USERS' SCORE
Good
Based on 5 Reviews
8.5
9
Magnesium reduces migraine symptoms
We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
9
Migraine relief
Most Useful Review
4 people found this helpful
I take this Magnesium at least twice daily after meals, or if I forget, I take two at night after dinner. I no longer experience my usual migraines or headaches. Previously, I thought it was normal to have a migraine once a week, especially due to work stress and before my monthly period. Now, I’ve forgotten when I last had a migraine. I'm grateful to my husband for suggesting Magnesium. ☺️
Updated: Mar 2026
Bloating details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.4
USERS' SCORE
Good
Based on 3 Reviews
8.4
8
We explored the impact of magnesium supplementation on bloating as part of a larger study examining premenstrual symptoms. In our randomized, double-blind, placebo-controlled design, we administered a daily dose of 200 mg of magnesium (as MgO) to participants over the course of two menstrual cycles. Each volunteer kept track of their symptoms using a detailed diary with twenty-two items.
Initially, we found no difference in premenstrual symptoms between the magnesium and placebo groups during the first month. However, during the second month, participants taking magnesium experienced a notable decrease in bloating and hydration-related symptoms such as weight gain and breast tenderness. This reduction in symptoms was statistically significant, indicating that magnesium can indeed alleviate certain premenstrual symptoms like bloating.
Our findings suggest that magnesium supplementation, particularly in the context of fluid retention and bloating, could be beneficial for women experiencing these discomforts during their menstrual cycle. Overall, this study opens the door to considering magnesium as an effective remedy for mild premenstrual bloating.
Initially, we found no difference in premenstrual symptoms between the magnesium and placebo groups during the first month. However, during the second month, participants taking magnesium experienced a notable decrease in bloating and hydration-related symptoms such as weight gain and breast tenderness. This reduction in symptoms was statistically significant, indicating that magnesium can indeed alleviate certain premenstrual symptoms like bloating.
Our findings suggest that magnesium supplementation, particularly in the context of fluid retention and bloating, could be beneficial for women experiencing these discomforts during their menstrual cycle. Overall, this study opens the door to considering magnesium as an effective remedy for mild premenstrual bloating.
7.5
No side effects
Most Useful Review
8 people found this helpful
No Gastrointestinal Side Effects. With this Magnesium Oxide supplement from Solgar, you gain the benefits of Magnesium without the side effects like bloating and gas that other brands cause. I've experienced none at all with Solgar. Instead, I've had less muscle and nerve pain and improved sleep.
Updated: Mar 2026
Brain Tumor details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.1
USERS' SCORE
Good
Based on 3 Reviews
8.4
8
We explored the impact of the vitamin B6 pathway on glioblastoma, a challenging and aggressive brain cancer. Specifically, we assessed how different cell cultures—2D monolayers and 3D spheroids—responded to treatments that alter vitamin B6 levels. Through comprehensive metabolomics analysis, we found notable differences in the levels of vitamin B6-related metabolites between these two culture methods.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
9
Improves wellbeing
Most Useful Review
Significantly enhances well-being and sleep, with a positive impact on brain function.
Updated: Mar 2026
Gastritis details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7
USERS' SCORE
Good
Based on 2 Reviews
8.4
7
We explored the impact of chronic stress on gastritis and how vitamin B6 might play a role in treatment. In our investigation, we employed the water avoidance stress test in mouse models to simulate the impacts of stress on the stomach. This method allowed us to closely examine how stress alters gastric conditions and the microbiota.
Our findings indicated that water avoidance stress led to decreased levels of hydrogen sulfide (H2S) in the stomach, which correlated with increased inflammation and disruption of the stomach's microbiota. When we supplemented with sodium hydrosulfide and vitamin B6, we observed partial reversal of inflammation and microbial imbalance.
Although vitamin B6 alone was tested alongside sodium hydrosulfide, it shows promise as a potential treatment option for stress-induced gastritis. This is especially relevant given the rising incidence of chronic gastritis linked to high-stress lifestyles. Our research offers insights that could pave the way for new strategies to prevent and treat gastritis related to stress.
Our findings indicated that water avoidance stress led to decreased levels of hydrogen sulfide (H2S) in the stomach, which correlated with increased inflammation and disruption of the stomach's microbiota. When we supplemented with sodium hydrosulfide and vitamin B6, we observed partial reversal of inflammation and microbial imbalance.
Although vitamin B6 alone was tested alongside sodium hydrosulfide, it shows promise as a potential treatment option for stress-induced gastritis. This is especially relevant given the rising incidence of chronic gastritis linked to high-stress lifestyles. Our research offers insights that could pave the way for new strategies to prevent and treat gastritis related to stress.
9
Effective for gastritis
Most Useful Review
I have found this company and its product to be excellent. Some people are hesitant about the magnesium oxide content, but for gastritis or an ulcer, it's precisely what’s needed. A quick search online will yield ample information. I highly recommend it!
Updated: Apr 2025
Hair Loss details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 9 Reviews
8.4
9
We explored a novel approach to tackle hair loss by using a 3D multicellular micropattern that includes magnesium silicate (MS) nanomaterials. This innovative method involved carefully positioning hair follicle-related cells in a structured network along with vascular cells, all created through advanced bioprinting techniques.
The incorporation of magnesium silicate aimed to enhance both hair follicle potential and the formation of new blood vessels—factors crucial for healthy hair growth. Our findings revealed promising results, showing that this 3D micropattern with MS significantly promoted hair regrowth in models of skin tissue regeneration, including both immunodeficient mice and those with androgenetic alopecia.
Essentially, we demonstrated that integrating magnesium with a well-designed cell arrangement could lead to better hair restoration outcomes. This significant insight contributes to the ongoing search for effective treatments for hair loss, bridging biological engineering and dermatology in the process.
The incorporation of magnesium silicate aimed to enhance both hair follicle potential and the formation of new blood vessels—factors crucial for healthy hair growth. Our findings revealed promising results, showing that this 3D micropattern with MS significantly promoted hair regrowth in models of skin tissue regeneration, including both immunodeficient mice and those with androgenetic alopecia.
Essentially, we demonstrated that integrating magnesium with a well-designed cell arrangement could lead to better hair restoration outcomes. This significant insight contributes to the ongoing search for effective treatments for hair loss, bridging biological engineering and dermatology in the process.
7.5
Improved hair condition
Most Useful Review
1 people found this helpful
An effective vitamin and mineral complex that revitalised me! If you have depression, hair loss, and insomnia, you likely have a magnesium deficiency. It's unfortunate that doctors don't explain these basics to us!
Updated: Mar 2026
Abscess details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.3
9
Tension relief noted
Most Useful Review
I absolutely adore the firm Solgar and their excellent vitamins! I take magnesium every year, especially during spring and autumn when I feel down. Occasionally, I take it if I notice I’m starting to feel overwhelmed. It effectively relieves tension! My doctor mentioned it's beneficial to take in summer, especially when the sun is shining. It's also much cheaper than buying from a pharmacy!
Updated: Apr 2025
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.3
8
We explored the effects of vitamin B6, specifically its active form called pyridoxal phosphate (PLP), on allergic responses. Our research focused on how this vitamin might influence interleukin-33 (IL-33), a key cytokine involved in type 2 inflammation, typically seen in asthma and other allergic conditions.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
7.5
Noticeable improvements
Most Useful Review
53 people found this helpful
Helps with cracked toes. My daughter, aged 10, has been taking magnesium regularly. She also suffers from allergies, which for the past six years has caused her fingers to be coarse and peeling. While creams provide temporary relief, they do not address the underlying cause. I discovered from nutritionists that a deficiency in vitamin B6 could lead to such symptoms. I quickly purchased it, and to my delight, the improvements were immediately noticeable. I'm now considering giving it to my husband, as he also has a similar hereditary issue. If anyone else faces this problem, I recommend giving it a go.
Updated: Apr 2025
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.3
9
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
7.5
Anxiety management
Most Useful Review
22 people found this helpful
Following a prescription for anxiety, I found magnesium combined with vitamin B6 to be beneficial. The large capacity means it lasts for several months, which is excellent.
Updated: Mar 2026
Back Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.8
USERS' SCORE
Good
Based on 4 Reviews
8.3
9.5
We explored the effectiveness of magnesium sulfate (MS) in relieving low back pain (LBP) for patients who underwent iliac venous stenting. This study involved 97 patients, divided into two groups: one received MS infusion during their surgery, while the other did not.
Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.
Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.
Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
9
Reduced back pain
Most Useful Review
3 people found this helpful
Great Vitamin! My husband and I have both suffered from osteochondrosis and need magnesium B6. After two weeks, I noticed that my back pain has diminished considerably. It feels as if I'm in Zen; nothing bothers me now. We take it three times a day.
Updated: Apr 2025
Celiac details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.3
9
Reduces stress effectively
Most Useful Review
1 people found this helpful
This product has proven to be excellent for coping with stress. It’s non-GMO, gluten-free, and suitable for vegans. I appreciate the aesthetic of the jar, and all Solgar products adhere to international GMP standards. The small tablets are easy to swallow, and I have observed a noticeable calmness both mentally and physically since I began taking it. It also ensured sound sleep without any adverse reactions.
Updated: Mar 2026
Frozen Shoulder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.3
9
Deep sleep enhancement
Most Useful Review
This product worked wonders for my muscle strain and pain from back to shoulder and neck. I rested well and had deep, comfortable sleep. It relaxes the nerves effectively, providing better relief than many pills combined. I improved significantly, and I stopped taking it after I felt better.
Updated: Mar 2026
Kidney Stones details
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.3
USERS' SCORE
Good
Based on 14 Reviews
8.3
9
Magnesium reduces kidney stone risk
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.
After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.
Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.
Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
10
Doctor's recommendation
Most Useful Review
19 people found this helpful
Excellent for kidney stone prevention! My urologist recommended these tablets, citing studies that show B6 and Magnesium can prevent kidney stones in women. I’ve been taking them for 2-3 years, and they are absolutely fantastic! Although the recommended dosage is three tablets daily, I take only two, one in the morning and one in the evening with meals, and I haven’t had any issues with new stones.
Updated: Mar 2026
Knee Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.3
9
Magnesium sulfate alleviates postoperative pain
We explored the impact of magnesium sulfate on managing pain following total knee arthroplasty. In a randomized, double-blind trial with 90 patients, half received a blend of analgesics that included magnesium sulfate, while the other half did not.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
7.5
Overall improvement
Most Useful Review
1 people found this helpful
I want to praise this magnesium + B6. Since taking it, the twisting pain in my legs and knees ceased, and my overall well-being has significantly improved.
Updated: Apr 2026
Leg Cramps details
SCIENTIFIC SCORE
Likely Ineffective
Based on 17 Researches
4.8
USERS' SCORE
Good
Based on 66 Reviews
8.3
9
Magnesium oxide treats leg cramps
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
9
Improved sleep, cramps eased
Most Useful Review
381 people found this helpful
I made up for the magnesium deficiency and began to sleep peacefully. It helped a lot with leg cramps; I recommend it!👍
Updated: Mar 2026
Bone Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
USERS' SCORE
Good
Based on 5 Reviews
8.2
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
9
Beneficial supplement
Most Useful Review
2 people found this helpful
This supplement is vital for muscle and bone health. It significantly improves my sleep, and I have benefited greatly, for which I am thankful.
Updated: Mar 2026
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 18 Reviews
8.2
8
Magnesium potentially benefits CFS patients
We investigated the relationship between magnesium levels in red blood cells and chronic fatigue syndrome (CFS). A case-control study revealed that CFS patients had lower magnesium levels than healthy individuals.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
9
Fatigue disappeared
Most Useful Review
10 people found this helpful
In one word, Solgar! After being prescribed magnesium with vitamin B6 by three doctors due to chronic stress and smoking, I felt a surge of energy almost immediately. My fatigue vanished, and I no longer woke up at night. I'm pleased to have found this quality product.
Updated: Mar 2026
Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.8
USERS' SCORE
Good
Based on 5 Reviews
8.2
8
We examined how incorporating fly ash into magnesium phosphate repair mortar (MPM) influences its effectiveness in cold environments. Our investigation revealed that fly ash modifies the microstructure of the MPM, enhancing its performance without affecting the setting time or fluidity significantly.
We discovered that adding 10% to 15% fly ash improves the mechanical strength, adhesion, water resistance, and stability of the mortar. Notably, we found that the curing temperature plays a critical role; as the temperature rises, compressive strength increases, while properties like flexural strength decrease.
Interestingly, even when cured in icy conditions at -20°C or 0°C, MPM with fly ash retains good early strength and strong adhesion properties. This suggests magnesium phosphate repair mortar modified with fly ash is suitable for emergency repairs in cold weather, showcasing its potential for use in challenging environments.
We discovered that adding 10% to 15% fly ash improves the mechanical strength, adhesion, water resistance, and stability of the mortar. Notably, we found that the curing temperature plays a critical role; as the temperature rises, compressive strength increases, while properties like flexural strength decrease.
Interestingly, even when cured in icy conditions at -20°C or 0°C, MPM with fly ash retains good early strength and strong adhesion properties. This suggests magnesium phosphate repair mortar modified with fly ash is suitable for emergency repairs in cold weather, showcasing its potential for use in challenging environments.
9
Immunity protected
Most Useful Review
I've been using these excellent vitamins since early January, and the effects are already apparent. I no longer constantly feel drowsy and my sleep quality has greatly improved, making it easier to drift off. I'm full of energy and strength, benefitting both my daily activities and sports. My immunity seems stronger as I haven’t caught a cold, which is unusual for me during winter. The dosage lasts quite some time, allowing for less frequent intake.
Updated: Apr 2025
Flu details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 5 Reviews
8.2
7
We explored how magnesium affects our immune response, particularly in relation to fighting off influenza. By examining how magnesium levels influence T cell function, we noticed that lower levels of magnesium in the body could hinder the T cell receptor (TCR) activation process. This is significant because TCR activation is crucial for mounting an effective immune response against viruses like influenza.
Our findings revealed that insufficient magnesium decreases the activation of important immune cells, specifically CD8 T cells, which are vital for responding to infections. This was further demonstrated in mice where reduced serum magnesium concentrations led to weaker immune responses and more severe illness from influenza A virus.
Overall, we observed that magnesium not only serves as an essential cofactor in cellular processes but also plays a direct role in maintaining strong immune function. Ensuring an adequate intake of magnesium is therefore important for enhancing our ability to combat viral infections effectively.
Our findings revealed that insufficient magnesium decreases the activation of important immune cells, specifically CD8 T cells, which are vital for responding to infections. This was further demonstrated in mice where reduced serum magnesium concentrations led to weaker immune responses and more severe illness from influenza A virus.
Overall, we observed that magnesium not only serves as an essential cofactor in cellular processes but also plays a direct role in maintaining strong immune function. Ensuring an adequate intake of magnesium is therefore important for enhancing our ability to combat viral infections effectively.
9
Stress relief
Most Useful Review
💥💥💥 COOL COMPLEX💥💥💥 I purchased this product due to stress, irritability, and poor sleep. After a week, I feel much better! My nervousness has reduced, and I have more energy. It's great support for my body! The packaging is convenient, with 250 tablets, making it very economical.
Updated: Mar 2026
Heart Attack details
SCIENTIFIC SCORE
Questionable
Based on 29 Researches
6.7
USERS' SCORE
Good
Based on 3 Reviews
8.2
9
We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
7.5
Less painful cramps
Most Useful Review
I took this magnesium during my pregnancy as I was plagued by night cramps. With this supplement, the frequency and pain of my nighttime attacks decreased significantly.
Updated: Mar 2026
Menopause details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
USERS' SCORE
Good
Based on 6 Reviews
8.2
9
We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
9
Improved mood and sleep
Most Useful Review
I absolutely love this drug. My sleep is fantastic, my mood is stable, and I feel calm. I take 2 tablets in the morning after breakfast, and the effect is very good, especially for women experiencing menopause. I highly recommend it!
Updated: Apr 2025
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.5
USERS' SCORE
Good
Based on 6 Reviews
8.1
9
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
9
Support for well-being
Most Useful Review
1 people found this helpful
After taking magnesium B6 for two months as my doctor prescribed, I decided to leave a review. This product is a solid alternative to pharmacy magnesium B6—better in terms of price and quantity. Magnesium is vital for the body's proper functioning, aiding blood vessel strength, normalising blood pressure, and improving muscle relaxation, which helped me overcome depression.
Updated: Mar 2026
Irritable Bowel Syndrome details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.1
USERS' SCORE
Good
Based on 8 Reviews
8.1
8
We set out to understand how magnesium sulphate influences the symptoms of irritable bowel syndrome (IBS). In a study involving 20 IBS patients, magnesium sulphate was administered orally, resulting in a quick boost in colonic motor activity. Most participants experienced this increase within just two to six minutes.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
9
Much calmer
Most Useful Review
1 people found this helpful
I’ve realised this product is perfect for me! Being quite emotional and quick-tempered, magnesium B6 has made me much calmer and less irritable. I truly love it and recommend it to everyone!
Updated: Apr 2025
Swollen Lymph Nodes details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.1
9
Swelling reduced
Most Useful Review
15 people found this helpful
I found the magnesium extremely beneficial! I began taking three a day for two months. I previously experienced chest compressions and irritability, but all that has disappeared. More importantly, I encouraged my mother, who suffered from severe swelling in her feet due to heart issues, to try this complex. She had been prescribed Detroleks, which did not help. After a month of magnesium with B6, her swelling was gone, and she was thrilled! I've ordered more as it’s truly effective!
Updated: Apr 2025
Diabetes details
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.5
USERS' SCORE
Good
Based on 10 Reviews
8
8
Magnesium intake benefits diabetes patients
We investigated the link between dietary magnesium intake and the risk of heart disease and death in over 149,000 individuals, including those with type 2 diabetes. Through careful analysis over a median of 12 years, we found that higher magnesium intake was associated with significantly lower risks of heart disease and mortality in individuals with diabetes.
However, this benefit wasn't seen in those without diabetes. Our findings highlight the potential for magnesium to play a crucial role in health management for people living with type 2 diabetes, signaling the need for tailored dietary guidance.
However, this benefit wasn't seen in those without diabetes. Our findings highlight the potential for magnesium to play a crucial role in health management for people living with type 2 diabetes, signaling the need for tailored dietary guidance.
9
Enhances insulin sensitivity
Most Useful Review
3 people found this helpful
I am very pleased with Magnesium combined with Vitamin B6! This product has been a real saviour for me and my family. It has notably aided my family members with diabetes by improving their insulin sensitivity and helping manage their blood sugar levels, making it easier for them to control their condition. Additionally, it offers benefits for other family members, supporting heart health, strengthening bones, and enhancing overall well-being.
Updated: Mar 2026
Nausea details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.2
USERS' SCORE
Good
Based on 5 Reviews
8
8
We conducted a study to discover how magnesium sulfate affects nausea during orthognathic surgery. In this research, we divided 75 adult patients into two groups: one group received magnesium sulfate, while the other received a placebo saline solution.
We discovered that those who received magnesium experienced significantly less postoperative nausea and vomiting (PONV) compared to the control group. Specifically, at two hours post-surgery, patients in the magnesium group reported less severe PONV.
Additionally, this group also had lower requirements for remifentanil, a pain reliever, indicating that magnesium not only helps with nausea but may also play a role in overall pain management during recovery. The magnesium levels in the blood after surgery were notably higher in the magnesium group, further supporting its effectiveness.
This research suggests that incorporating magnesium sulfate into treatment protocols during orthognathic surgeries can greatly enhance patient comfort by minimizing nausea and improving pain control.
We discovered that those who received magnesium experienced significantly less postoperative nausea and vomiting (PONV) compared to the control group. Specifically, at two hours post-surgery, patients in the magnesium group reported less severe PONV.
Additionally, this group also had lower requirements for remifentanil, a pain reliever, indicating that magnesium not only helps with nausea but may also play a role in overall pain management during recovery. The magnesium levels in the blood after surgery were notably higher in the magnesium group, further supporting its effectiveness.
This research suggests that incorporating magnesium sulfate into treatment protocols during orthognathic surgeries can greatly enhance patient comfort by minimizing nausea and improving pain control.
9
No side effects noted
Most Useful Review
I used to take pharmacy MgB6, but many caused nausea and were ineffective. This magnesium works exceptionally well for me; it has a calming effect, and I feel more resilient to stress without any side effects. Additionally, it's cheaper and easier to take just 1 small tablet twice a day, unlike the large pills I had to take before.
Updated: Apr 2025
Premenstrual Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 57 Reviews
8
9
Highly effective magnesium
Most Useful Review
22 people found this helpful
I highly recommend this to women suffering from PMS (premenstrual syndrome). I bought this product after learning about the benefits of calcium and magnesium before my period, and it effectively relieved my PMS irritability. This seems more important than calcium to me. I don't even notice when my period is approaching. I have been taking the company's iron supplements for anaemia, which helped my blood tests and physical strength, but didn’t help much with irritability. I believe magnesium is what I was missing. It would be wise to raise awareness about magnesium supplements. I look forward to continuing using Solgar, given its quality.
Updated: Apr 2025
Rash details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8
9.5
We investigated how magnesium deficiency affects rash in hairless rats, which develop a severe, itchy rash resembling atopic dermatitis. In our study, we tested a derivative called SDZ ASM 981, given either systemically or topically. Remarkably, oral treatment with SDZ ASM 981 significantly cleared the rash within just one day.
Furthermore, this treatment reduced several inflammatory markers, showing promising results for both prevention and therapy. This indicates that magnesium's role might be crucial in managing similar skin conditions in humans, reinforcing the value of this rat model for effective treatment evaluation.
Furthermore, this treatment reduced several inflammatory markers, showing promising results for both prevention and therapy. This indicates that magnesium's role might be crucial in managing similar skin conditions in humans, reinforcing the value of this rat model for effective treatment evaluation.
9
Quick relief
Most Useful Review
Recently, I experienced a severe eye rash after ordering this product, which disappeared immediately! I am eager to take it regularly.
Updated: Apr 2025
Blood Clot details
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.8
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.9
8
Magnesium scaffold shows promising results
We investigated the clinical safety and performance of a new magnesium scaffold known as DREAMS 3G. This innovative treatment aims to match the effectiveness of drug-eluting stents in coronary interventions.
Over one year, a total of 116 patients were monitored, showing promising results with minimal lumen loss and no adverse events like cardiac death or major thrombosis. Despite a few revascularization interventions, the scaffold appears to be a viable alternative.
Overall, our findings support its potential use in heart treatments.
Over one year, a total of 116 patients were monitored, showing promising results with minimal lumen loss and no adverse events like cardiac death or major thrombosis. Despite a few revascularization interventions, the scaffold appears to be a viable alternative.
Overall, our findings support its potential use in heart treatments.
9
Overall improvement
Most Useful Review
1 people found this helpful
After taking magnesium for a month, my blood pressure normalised, headaches disappeared, and I felt more energised and alert in the morning. I highly recommend it for anyone seeking a similar outcome!
Updated: Mar 2026
Pelvic Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.3
USERS' SCORE
Moderately Good
Based on 39 Reviews
7.9
8
We evaluated how magnesium pidolate impacts primary dysmenorrhea in 30 young women. Over six menstrual cycles, we tracked their pain levels using a visual scale. Initially, no treatment was given, and subsequently, magnesium was administered just before menstruation.
The first day of menstrual pain showed a notable decrease with magnesium treatment, especially from the first to the sixth cycle. While there were some improvements on days two and three, those weren't statistically significant. Importantly, no side effects were reported, suggesting magnesium can be a reliable option for managing menstrual pain.
The first day of menstrual pain showed a notable decrease with magnesium treatment, especially from the first to the sixth cycle. While there were some improvements on days two and three, those weren't statistically significant. Importantly, no side effects were reported, suggesting magnesium can be a reliable option for managing menstrual pain.
9
Relieved chest pain
Most Useful Review
89 people found this helpful
Decent preparation, with excellent results. I had been suffering from aching pain in the right side of my chest, initially thought to be neuralgia. After tests, my doctor explained it could be due to a deficiency of magnesium and vitamin B6, so I ordered Solgar’s magneV6. Magnesium is crucial for muscle contraction and nerve impulses. Its deficiency can arise from dietary inadequacies or increased demand during stress. Along with alleviating my chest pain, I found a sense of calm and harmony throughout the two months of taking it.
Updated: Mar 2026
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.8
9
Magnesium deficiency reverses dizziness and ataxia successfully
A 68-year-old patient experienced unexplained dizziness, poor balance, and abnormal eye movements that stumped doctors despite extensive brain imaging and testing. The breakthrough came when doctors discovered severe magnesium deficiency caused by long-term use of proton pump inhibitor medications combined with a stomach infection. Once the magnesium was replaced through supplementation, the patient's symptoms improved.
This case highlights an important but often-missed cause of dizziness and balance problems. Magnesium deficiency can produce significant neurological symptoms without showing up on standard MRI scans, making diagnosis tricky. For patients experiencing dizziness along with digestive issues or taking certain common medications, magnesium testing should be a standard part of the evaluation to catch this treatable condition early.
This case highlights an important but often-missed cause of dizziness and balance problems. Magnesium deficiency can produce significant neurological symptoms without showing up on standard MRI scans, making diagnosis tricky. For patients experiencing dizziness along with digestive issues or taking certain common medications, magnesium testing should be a standard part of the evaluation to catch this treatable condition early.
9
Effective supplement
Most Useful Review
An excellent supplement! I recently began taking magnesium for severe leg cramps. Since starting Solgar, I've had no cramps, improved sleep, and no dizziness. This product effectively meets my needs.
Updated: Apr 2026
Sleep Apnea details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Moderately Good
Based on 95 Reviews
7.8
7
We aimed to uncover the relationship between magnesium levels and sleep quality, particularly focusing on sleep apnea. Our study analyzed data from a large group of adults aged 20 and older, using a well-structured method to assess magnesium levels and the prevalence of sleep issues.
We found a notable connection between lower magnesium levels, measured as the magnesium depletion score (MDS), and the likelihood of experiencing sleep apnea. Specifically, individuals with higher MDS levels were significantly more likely to report sleep apnea, showing over three times the odds compared to those with adequate magnesium levels.
Interestingly, our research did not link magnesium deficiency to other sleep problems like insomnia or restless legs syndrome, suggesting a more complex relationship with sleep apnea alone. Additionally, we noticed that older adults with depressive symptoms showed a tendency toward excessive sleep rather than insufficient sleep.
While our findings highlight the association between magnesium deficiency and sleep apnea, they also point towards the potential of adequate magnesium intake in reducing this risk. This emphasizes the importance of maintaining proper magnesium levels for better sleep quality, especially in those at higher risk for sleep apnea.
We found a notable connection between lower magnesium levels, measured as the magnesium depletion score (MDS), and the likelihood of experiencing sleep apnea. Specifically, individuals with higher MDS levels were significantly more likely to report sleep apnea, showing over three times the odds compared to those with adequate magnesium levels.
Interestingly, our research did not link magnesium deficiency to other sleep problems like insomnia or restless legs syndrome, suggesting a more complex relationship with sleep apnea alone. Additionally, we noticed that older adults with depressive symptoms showed a tendency toward excessive sleep rather than insufficient sleep.
While our findings highlight the association between magnesium deficiency and sleep apnea, they also point towards the potential of adequate magnesium intake in reducing this risk. This emphasizes the importance of maintaining proper magnesium levels for better sleep quality, especially in those at higher risk for sleep apnea.
9
Increased relaxation
Most Useful Review
109 people found this helpful
Excellent magnesium, absorbs well with B6. My sleep has become stronger, and my muscles rest and relax. This manufacturer always provides top-quality products.
Updated: Mar 2026
Adenoiditis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.7
7.5
Improved sleep quality
Most Useful Review
I recommend! I ordered magnesium from Solgar about 2.5 months ago; my sleep disorders were ongoing. Initially, I did not notice any effects, but after a month, the lump in my throat began to diminish, and my sleep has improved significantly. I've learned to manage my panic attacks. While magnesium isn't a cure-all, it has been a positive step towards achieving stability and comfort. By the end of the course, I realised my neurology issues had subsided for a considerable time. I discovered that Magnelis is pricier than Solgar, yet I have more confidence in Aycherb's production.
Updated: Apr 2025
Athlete’s Foot details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.7
7.5
Eases foot cramps
Most Useful Review
I have been using this product for several months, and it has been instrumental in helping me with foot cramps.
Updated: Apr 2025
Chronic Cough details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.7
9
Alleviated fatigue
Most Useful Review
4 people found this helpful
Magne B6 from Solgar has been my go-to, always providing excellent value for a three-month supply. It has helped alleviate chronic fatigue and insomnia. I recommend it particularly to pregnant women for muscle spasms. It has been consistently beneficial for me.
Updated: Apr 2025
Constipation details
SCIENTIFIC SCORE
Questionable
Based on 24 Researches
6.8
USERS' SCORE
Moderately Good
Based on 14 Reviews
7.7
9
We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
9
Kid's constipation remedy
Most Useful Review
This worked wonders for my 5-year-old son who frequently experiences constipation. I give him 2 tablets of this magnesium and 1 tablet of milk thistle, and it leads to immediate relief.
Updated: Mar 2026
Heart Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.8
USERS' SCORE
Moderately Good
Based on 20 Reviews
7.7
7
We examined how magnesium supplements might influence heart failure and serious heart-related issues in diabetic patients.
In a study involving over 94,000 veterans, we found that those taking magnesium supplements experienced a lower risk of heart failure compared to nonusers. Specifically, 8.0% of supplement users developed heart failure, versus 9.7% of nonusers.
Furthermore, magnesium intake was linked to a reduced chance of major adverse cardiac events. However, it’s important to note that these findings need further investigation through randomized controlled trials.
In a study involving over 94,000 veterans, we found that those taking magnesium supplements experienced a lower risk of heart failure compared to nonusers. Specifically, 8.0% of supplement users developed heart failure, versus 9.7% of nonusers.
Furthermore, magnesium intake was linked to a reduced chance of major adverse cardiac events. However, it’s important to note that these findings need further investigation through randomized controlled trials.
8
Overall health supported
Most Useful Review
2 people found this helpful
These Solgar supplements deliver a great combination of magnesium and vitamin B6. They aid heart health, regulate calcium absorption, and support overall bodily functions. I've found this synergy to be greatly beneficial to my wellbeing.
Updated: Apr 2025
Autoimmune Disorder details
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.3
USERS' SCORE
Moderately Good
Based on 46 Reviews
7.6
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
9
Visible results achieved
Most Useful Review
8 people found this helpful
I bought this product for my seven-year-old son, hoping for better results than other medications we've tried, as directed by a neurologist. Unlike other brands, this drug has shown immediate improvement in his condition. I administer it morning and evening with meals. I’ve even started giving it to my eldest daughter as she prepares for exams, and we all notice the excellent results. I'll definitely order more. Stay healthy!
Updated: Mar 2026
Food Poisoning details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.3
USERS' SCORE
Medium or Average
Based on 8 Reviews
6.9
9
We explored an intriguing connection between vitamin B6 and something called the Chinese Restaurant Syndrome, often linked to the consumption of monosodium L-glutamate (MSG). This study involved a group of 155 students who had not taken extra vitamin B6. By analyzing an enzyme called aspartate transaminase in their blood cells, we identified 27 individuals with notably low levels, which suggested they might have a vitamin B6 deficiency.
Among these 27 participants, we challenged them with glutamate and a placebo, where 12 recognized symptoms associated with the syndrome while 15 did not. Through a double-blind treatment over twelve weeks, we administered pyridoxine (a form of vitamin B6) and a placebo. After completing the treatment, we re-challenged them with glutamate.
We found that those who received pyridoxine showed a significant decrease in symptoms, proving treatment was effective for most of them. Specifically, only 3 of the 12 who received placebo experienced the symptoms again, while 8 of the 9 who had pyridoxine did not react to glutamate. Our results indicate a strong link between vitamin B6 levels and the management of symptoms tied to this syndrome, suggesting that vitamin B6 may play a critical role in enhancing our resilience against certain forms of food-related discomfort.
Among these 27 participants, we challenged them with glutamate and a placebo, where 12 recognized symptoms associated with the syndrome while 15 did not. Through a double-blind treatment over twelve weeks, we administered pyridoxine (a form of vitamin B6) and a placebo. After completing the treatment, we re-challenged them with glutamate.
We found that those who received pyridoxine showed a significant decrease in symptoms, proving treatment was effective for most of them. Specifically, only 3 of the 12 who received placebo experienced the symptoms again, while 8 of the 9 who had pyridoxine did not react to glutamate. Our results indicate a strong link between vitamin B6 levels and the management of symptoms tied to this syndrome, suggesting that vitamin B6 may play a critical role in enhancing our resilience against certain forms of food-related discomfort.
9
High blood pressure
Most Useful Review
4 people found this helpful
This magnesium, combined with taurine, has been very effective in managing my high blood pressure. My entire family uses it, and I’ve found better results compared to alternatives. After a month, I stopped needing my blood pressure pills—highly recommended!
Updated: Mar 2026
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Medium or Average
Based on 14 Reviews
6.9
9
We aimed to find out how magnesium chloride influences liver health and oxidative stress in rats on a high-fat diet.
In our study, groups of rats were fed either a normal diet, a high-fat diet, or a high-fat diet supplemented with magnesium chloride.
We found that those receiving magnesium showed lower levels of liver enzymes and oxidative stress markers compared to the high-fat diet group alone.
This suggests that magnesium chloride could help protect against the harmful effects of a high-fat diet, although its efficacy in humans needs further investigation.
In our study, groups of rats were fed either a normal diet, a high-fat diet, or a high-fat diet supplemented with magnesium chloride.
We found that those receiving magnesium showed lower levels of liver enzymes and oxidative stress markers compared to the high-fat diet group alone.
This suggests that magnesium chloride could help protect against the harmful effects of a high-fat diet, although its efficacy in humans needs further investigation.
9
Restored health
Most Useful Review
2 people found this helpful
I am a big fan of this brand! I have noticed a marked improvement in my well-being after taking their vitamins. They have played a significant role in alleviating fatigue and anxiety, especially after having COVID. I appreciate the natural ingredients and the dark bottle in which they are stored, which adds to their quality. I highly recommend this product for the entire family, as it has helped restore sleep and overall health.
Updated: Mar 2026
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.4
USERS' SCORE
Medium or Average
Based on 20 Reviews
6.6
9
Magnesium aids migraine management
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
9
Balanced stress relief
Most Useful Review
After trying various magnesium brands that gave me headaches, this one was effective. Within a week, I felt deeper sleep and improved balance in stressful situations.
Updated: Mar 2026
Diarrhea details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.4
USERS' SCORE
Medium or Average
Based on 9 Reviews
6.4
9.5
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
9
No side effects
Most Useful Review
8 people found this helpful
No gastrointestinal side effects. With this Magnesium Oxide supplement by Solgar, I benefit from magnesium without the malabsorption issues suffered with other brands. Other supplements caused bloating, gas, stomach pain, and diarrhea, but I have had none of those with Solgar. It's helped reduce my muscle and nerve pain, and I enjoy much more restful sleep. Having taken Magnesium Oxide for over 7 years for my sciatica pain, it keeps the pain at bay, which was previously unbearable. The dosage of three pills allows me to take one every eight hours, and I feel great!
Updated: Apr 2025
Data last updated:
