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Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Magnesium (from Magnesium Aspartate)
250 mg
60%
Potassium (from Potassium Aspartate)
99 mg
2%
Taurine (Free-Form)
100 mg
†
The product is found useful for the following medical conditions
Leg Cramps
SCIENTIFIC SCORE
Likely Ineffective
Based on 16 Researches
4.7
USERS' SCORE
Excellent
Based on 15 Reviews
9.1
9
Magnesium oxide treats leg cramps
A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
Most Relevant Research
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
10
Amazing results
Most Useful Review
UPDATE: These supplements continue to work for me. I am usually sceptical about new products, especially when they receive rave reviews. I suffered from leg and foot cramps at night, causing me to bolt out of bed in pain. Potassium and magnesium were said to be helpful, and after taking two a day for a week or two, all my cramping ceased. I'm a firm believer in the power of the right supplements.
Constipation
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7
USERS' SCORE
Good
Based on 15 Reviews
8.7
4
Effectiveness of magnesium on constipation
Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study.
Most Relevant Research
We explored how changing the frequency of magnesium oxide (MgO) doses influences its effectiveness in relieving constipation. In this study, we looked at 11 patients who had been regularly using MgO to manage their bowel movements and decided to reduce their daily dose frequency over two weeks.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
9.5
Relieves constipation
Most Useful Review
This product, containing magnesium and potassium, supports heart function but has unexpectedly helped with my autoimmune disease treatment. It combats cramps, constipation, and sleep disturbances caused by prednisolone. I take two capsules at night, and the quality is excellent. It’s now a permanent fixture in my orders.
Irritable Bowel Syndrome
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 12 Reviews
8.7
8
Magnesium boosts colonic activity
Effects of oral magnesium sulphate on colonic motility in patients with the irritable bowel syndrome.
Most Relevant Research
We set out to understand how magnesium sulphate influences the symptoms of irritable bowel syndrome (IBS). In a study involving 20 IBS patients, magnesium sulphate was administered orally, resulting in a quick boost in colonic motor activity. Most participants experienced this increase within just two to six minutes.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
9.5
Reduced cramps
Most Useful Review
Magnesium and potassium support heart health, but I've found they help with my autoimmune disease. As I'm on prednisolone, I face side effects like cramps and constipation. Magnesium and potassium aspartate eased my cramps, improved my bowel function, and helped my sleep. I take two capsules at night with a light meal and highly rate this product.
Headache
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.6
USERS' SCORE
Good
Based on 13 Reviews
8.6
9
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
10
No migraines
Most Useful Review
I haven't had any headaches for three weeks since I began taking two capsules twice a day. I have not required any pharmaceutical drugs to manage my migraines, which is fantastic!
Dizziness
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.6
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Magnesium's role in Meniere's treatment
Successful treatment of a child with definite Meniere's disease with the migraine regimen.
Most Relevant Research
We observed the intriguing connection between Meniere's disease (MD) and migraine-related dizziness in our study of a 5-year-old girl. She experienced a six-month struggle with left-sided hearing loss, which evolved into daily bouts of vertigo, headaches, and vomiting, fulfilling the criteria for definite MD.
After implementing a specialized six-week migraine diet and lifestyle plan that included riboflavin and magnesium, we noted a remarkable transformation. The child became symptom-free and achieved nearly normal hearing levels, leading us to consider that MD symptoms might be linked to vestibular migraine triggers.
This suggests that young patients with MD could greatly benefit from lifestyle and dietary adjustments aimed at managing migraine symptoms. While magnesium was part of this regimen, it’s essential to look at it as one component of a broader approach. The results invite further exploration into how dietary interventions may alleviate both cochlear and vestibular symptoms in Meniere's disease.
After implementing a specialized six-week migraine diet and lifestyle plan that included riboflavin and magnesium, we noted a remarkable transformation. The child became symptom-free and achieved nearly normal hearing levels, leading us to consider that MD symptoms might be linked to vestibular migraine triggers.
This suggests that young patients with MD could greatly benefit from lifestyle and dietary adjustments aimed at managing migraine symptoms. While magnesium was part of this regimen, it’s essential to look at it as one component of a broader approach. The results invite further exploration into how dietary interventions may alleviate both cochlear and vestibular symptoms in Meniere's disease.
9.5
Eliminated dizziness
Most Useful Review
These prevent me from experiencing low blood pressure symptoms. I was on blood pressure medication and a diuretic, but my blood pressure would fluctuate dramatically. I often felt so dizzy that I couldn't sit or stand. After starting these pills, I noticed a significant decrease in dizziness. I'm extremely grateful I found these.
Back Pain
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.6
USERS' SCORE
Good
Based on 1 Review
8.5
9.5
Magnesium reduces postoperative back pain
Effect of perioperative intravenous magnesium sulfate on postoperative pain after iliac venous stenting.
Most Relevant Research
We explored the effectiveness of magnesium sulfate (MS) in relieving low back pain (LBP) for patients who underwent iliac venous stenting. This study involved 97 patients, divided into two groups: one received MS infusion during their surgery, while the other did not.
Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.
Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.
Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
8.8
Lowered arthritic pain
Most Useful Review
My blood pressure is back to normal after starting this supplement, and I have also experienced reduced arthritic pain in my hips, knees, and back.
Neuropathy
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.8
USERS' SCORE
Good
Based on 1 Review
8.5
9
Taurine aids diabetic neuropathy
Taurine ameliorates axonal damage in sciatic nerve of diabetic rats and high glucose exposed DRG neuron by PI3K/Akt/mTOR-dependent pathway.
Most Relevant Research
We explored how taurine can help in treating diabetic peripheral neuropathy, a common complication arising from diabetes characterized mainly by issues in nerve function. Our research demonstrated that taurine notably reduced blood sugar levels, alleviated insulin resistance, and improved abnormal nerve conduction in diabetic rats, showing its potential as a treatment option.
We observed that taurine not only corrected the damaged structure of axons in the sciatic nerve of these rats but also stimulated the growth of axons in Dorsal root ganglion (DRG) neurons that were exposed to high glucose levels. Moreover, taurine elevated the phosphorylation of key proteins in the PI3K/Akt/mTOR signaling pathway, which plays an important role in cell growth and survival.
However, when we applied specific inhibitors for Akt and mTOR, they blocked taurine's positive effects on axonal damage. This indicates that taurine’s protective benefits against axonal deterioration in diabetic rats depend on activating this particular signaling pathway. Our findings suggest that taurine might be a promising candidate for addressing nerve damage associated with diabetes.
We observed that taurine not only corrected the damaged structure of axons in the sciatic nerve of these rats but also stimulated the growth of axons in Dorsal root ganglion (DRG) neurons that were exposed to high glucose levels. Moreover, taurine elevated the phosphorylation of key proteins in the PI3K/Akt/mTOR signaling pathway, which plays an important role in cell growth and survival.
However, when we applied specific inhibitors for Akt and mTOR, they blocked taurine's positive effects on axonal damage. This indicates that taurine’s protective benefits against axonal deterioration in diabetic rats depend on activating this particular signaling pathway. Our findings suggest that taurine might be a promising candidate for addressing nerve damage associated with diabetes.
8.8
Minimal neuropathy
Most Useful Review
This product is helping to keep my neuropathy minimal and, I believe, aids a bit with my blood pressure as well.
Insomnia
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.4
USERS' SCORE
Good
Based on 15 Reviews
8.4
9
Magnesium improves elderly insomnia
The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
Most Relevant Research
We conducted a double-blind, placebo-controlled clinical trial to investigate the effects of magnesium supplementation on insomnia in elderly individuals. Our study involved 46 participants who were assigned either to receive 500 mg of magnesium daily or a placebo for a duration of 8 weeks.
Throughout the study, we employed various questionnaires, including the Insomnia Severity Index (ISI), to evaluate the participants' sleep quality both before and after the treatment period. We also monitored the intake of other nutrients and performed blood tests to assess hormone levels related to sleep.
The results showed that magnesium supplementation led to significant improvements in areas such as sleep efficiency, sleep onset timing, and overall insomnia severity. We observed increases in serum levels of melatonin and changes in cortisol and renin levels, indicating a physiological response that could enhance sleep quality.
Overall, it seems that supplementing with magnesium has the potential to improve sleep for older adults struggling with insomnia. This finding could pave the way for new, accessible treatment options for those affected by sleep disorders.
Throughout the study, we employed various questionnaires, including the Insomnia Severity Index (ISI), to evaluate the participants' sleep quality both before and after the treatment period. We also monitored the intake of other nutrients and performed blood tests to assess hormone levels related to sleep.
The results showed that magnesium supplementation led to significant improvements in areas such as sleep efficiency, sleep onset timing, and overall insomnia severity. We observed increases in serum levels of melatonin and changes in cortisol and renin levels, indicating a physiological response that could enhance sleep quality.
Overall, it seems that supplementing with magnesium has the potential to improve sleep for older adults struggling with insomnia. This finding could pave the way for new, accessible treatment options for those affected by sleep disorders.
10
First effective solution
Most Useful Review
This product truly works! After hearing about its benefits for insomnia, I ordered it, having suffered for years. I tried everything from sleeping pills to meditation, with no success. This was the first remedy that worked for me long-term and isn’t addictive, which is a massive plus. As a bartender, I also find it helps relieve muscle cramps after long hours on my feet.
Flu
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 1 Review
8.3
7
Magnesium essential for immune response
Mg regulation of kinase signaling and immune function.
Most Relevant Research
We explored how magnesium affects our immune response, particularly in relation to fighting off influenza. By examining how magnesium levels influence T cell function, we noticed that lower levels of magnesium in the body could hinder the T cell receptor (TCR) activation process. This is significant because TCR activation is crucial for mounting an effective immune response against viruses like influenza.
Our findings revealed that insufficient magnesium decreases the activation of important immune cells, specifically CD8 T cells, which are vital for responding to infections. This was further demonstrated in mice where reduced serum magnesium concentrations led to weaker immune responses and more severe illness from influenza A virus.
Overall, we observed that magnesium not only serves as an essential cofactor in cellular processes but also plays a direct role in maintaining strong immune function. Ensuring an adequate intake of magnesium is therefore important for enhancing our ability to combat viral infections effectively.
Our findings revealed that insufficient magnesium decreases the activation of important immune cells, specifically CD8 T cells, which are vital for responding to infections. This was further demonstrated in mice where reduced serum magnesium concentrations led to weaker immune responses and more severe illness from influenza A virus.
Overall, we observed that magnesium not only serves as an essential cofactor in cellular processes but also plays a direct role in maintaining strong immune function. Ensuring an adequate intake of magnesium is therefore important for enhancing our ability to combat viral infections effectively.
6.8
No flu symptoms
Most Useful Review
Seems to work. I started taking these when I commenced a keto diet and did not experience any keto flu symptoms, so I presume it worked. I would prefer if they could somehow pack the serving into one pill rather than taking two each morning.
Chest Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.1
USERS' SCORE
Moderately Good
Based on 1 Review
7.8
8
Magnesium supplementation aids chest pain
The prevalence of hypomagnesaemia in pediatric patients with mitral valve prolapse syndrome and the effect of mg therapy.
Most Relevant Research
We explored the effects of magnesium treatment on chest pain in pediatric patients suffering from mitral valve prolapse syndrome. In our study involving 230 young participants, we defined hypomagnesaemia as having a serum magnesium level below 1.5 mg/dl.
After identifying 19 patients with insufficient magnesium levels—representing about 8.2% of the group—we treated them with an oral magnesium chloride supplement for five weeks. We were eager to see whether this would help alleviate symptoms, particularly chest pain.
After the treatment period, we observed that magnesium therapy provided statistically significant relief of chest pain for these patients. However, we did not find substantial improvements in other symptoms like palpitations, fatigue, and dyspnea. This finding is vital, as it indicates that while magnesium may play a role in easing chest pain, its overall benefit to other symptoms remains uncertain.
Overall, our study highlights the relatively low prevalence of magnesium deficiency in pediatric patients with mitral valve prolapse compared to adults. Nevertheless, we concluded that magnesium supplementation could be a beneficial approach to address specific symptoms like chest pain in this population.
After identifying 19 patients with insufficient magnesium levels—representing about 8.2% of the group—we treated them with an oral magnesium chloride supplement for five weeks. We were eager to see whether this would help alleviate symptoms, particularly chest pain.
After the treatment period, we observed that magnesium therapy provided statistically significant relief of chest pain for these patients. However, we did not find substantial improvements in other symptoms like palpitations, fatigue, and dyspnea. This finding is vital, as it indicates that while magnesium may play a role in easing chest pain, its overall benefit to other symptoms remains uncertain.
Overall, our study highlights the relatively low prevalence of magnesium deficiency in pediatric patients with mitral valve prolapse compared to adults. Nevertheless, we concluded that magnesium supplementation could be a beneficial approach to address specific symptoms like chest pain in this population.
1.3
Chest pain stopped
Most Useful Review
I purchased these to replace potassium supplements for muscle cramps, having read about magnesium deficiency. After starting these, I experienced chest pains, prompting me to cease using them for two weeks. Upon resuming, the chest pains returned, but as soon as I stopped again, the chest pain ceased and hasn’t returned for the last year.
Anxiety
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.4
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
9
Taurine reduces anxiety, alcohol intake
Acute taurine reduced alcohol intake and preference in alcohol-experienced, but not in alcohol-näive rats by central mechanisms.
Most Relevant Research
We explored how taurine, a non-essential amino acid found in energy drinks, influences anxiety and alcohol intake in rats. The study involved both alcohol-naïve rats and those with a history of alcohol consumption, allowing us to see how taurine affects different groups.
Our findings showed that when taurine was administered directly into the brain, it significantly reduced alcohol consumption and preference in the alcohol-experienced rats. This suggests that taurine might help lessen the urge to drink in individuals struggling with alcohol use.
Interestingly, we also observed that taurine had an anxiolytic-like effect across all groups, meaning it seemed to reduce anxiety regardless of the rats' previous alcohol exposure. This dual effect highlights taurine's potential as a therapeutic option for anxiety and alcohol-related issues, making it a fascinating subject for further research.
Our findings showed that when taurine was administered directly into the brain, it significantly reduced alcohol consumption and preference in the alcohol-experienced rats. This suggests that taurine might help lessen the urge to drink in individuals struggling with alcohol use.
Interestingly, we also observed that taurine had an anxiolytic-like effect across all groups, meaning it seemed to reduce anxiety regardless of the rats' previous alcohol exposure. This dual effect highlights taurine's potential as a therapeutic option for anxiety and alcohol-related issues, making it a fascinating subject for further research.
0
Negative reaction experienced
Most Useful Review
BEWARE. These pills made me ill! I experienced diarrhoea and severe depression, and there should have been a warning about aspartate being potentially neurotoxic. This is my second unpleasant experience with a NOW Foods product. A previous study reported severe reactions in individuals with a history of depression after using a magnesium aspartate supplement, which might have worsened my mental state. Aspartate forms of magnesium should be avoided, particularly when managing anxiety or depression, as they can risk exacerbating these conditions.
Diarrhea
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.1
9.5
Magnesium shows potential for diarrhea
Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells.
Most Relevant Research
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
1
Dehydration risk
Most Useful Review
Terrible combo product with poor ratios and cheap fillers. Now was once a great value, but their formulations no longer make sense. To get even 25% of my RDA of potassium, I would need to consume half the bottle, which would lead to excessive magnesium intake and cause dehydration from diarrhoea. Overall, it’s a disappointing product.
