Gelatin enhances hair growth efficacyPromotion of hair growth by a conditioned medium from human umbilical cord mesenchymal stem cells cultivated in a 3D scaffold of gelatin sponge.
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We aimed to investigate whether a conditioned medium (CM) derived from human umbilical cord mesenchymal stem cells (HuMSCs) cultivated in a gelatin sponge could effectively promote hair growth. In our study, we compared two methods of culturing HuMSCs: the traditional monolayer and the novel three-dimensional (3D) approach using gelatin sponge.
Our findings revealed that the 3D culture significantly enhanced the production of key growth factors, including vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), keratinocyte growth factor (KGF), and hepatocyte growth factor (HGF). These factors are crucial for hair regeneration and skin health.
When we tested the conditioned medium and HuMSCs through injections into the back skin of mice experiencing hair loss, we noticed promising results. Both treatments stimulated hair regrowth, but the CM from the gelatin sponge culture showed even greater effects, leading to longer hair and improved growth rates. Notably, this treatment also promoted skin angiogenesis, which likely aided faster hair regrowth.
In summary, our exploration indicates that the use of gelatin-sponge-cultivated stem cell secretions can significantly bolster hair growth and support skin health in our mouse model.
Huge difference noted
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