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Supplement Facts
Serving Size: 3 Capsules
Amount Per Serving
%DV
Vitamin D3*
25 mcg (1000 IU)
125%
Magnesium**
300 mg
71%
Ancient Nutrients TCM BlendBeef Bone Broth, Bovine Liver, Organic Rhodiola Root Extract, Organic Turmeric Root Extract, Organic Stinging Nettle Root Extract, Chicken Bone Broth, Organic Cinnamon Bark Extract, Lion's Mane (Hericium erinaceus) Mushroom Extract, Organic Licorice Root Extract, Organic Skullcap Root Extract, Wild Hake Roe
450 mg
+
The product is found useful for the following medical conditions
Anxiety
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.6
9
CYP11A1, Autism Symptoms, Vitamin D3
Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention.
Most Relevant Research
We explored how overexpression of the CYP11A1 enzyme in the placenta can impact offspring and potentially lead to autism-like behaviors, particularly focusing on anxiety. Using a specialized murine model, we looked closely at how this genetic change affected social interactions and anxiety levels in the mice.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
9.5
Great for anxiety
Most Useful Review
PERFECT FOR HEADACHES & ANXIETY. This magnesium vitamin is pure, high quality, and effective. I'm often unsure about which type to use, but Dr. Axe has simplified that with this product! It helps me avoid headaches, manage my anxiety, and promotes a good night's sleep, making it essential for me.
Headache
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.8
USERS' SCORE
Good
Based on 1 Review
8.6
9
Vitamin D3 aids migraine relief
Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial.
Most Relevant Research
We conducted a rigorous study to explore how vitamin D3 supplementation might influence headaches in people suffering from migraines. By utilizing a well-structured, placebo-controlled, double-blind design, we included 80 participants with episodic migraines, assigning them either a daily dose of vitamin D3 or a placebo for 12 weeks.
After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.
Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.
After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.
Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.
9.5
Effective for headaches
Most Useful Review
This is a brilliant, high-quality magnesium vitamin. I'm often confused about which magnesium to choose, but Dr. Axe’s product has simplified it for me. It has significantly helped with my headaches, reduced anxiety, and has been fantastic for a good night's sleep. It's a must-have for me!
Leg Cramps
SCIENTIFIC SCORE
Likely Ineffective
Based on 16 Researches
4.7
USERS' SCORE
Good
Based on 1 Review
8.6
9
Magnesium oxide treats leg cramps
A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
Most Relevant Research
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
10
No more issues
Most Useful Review
Helps with leg cramps. I used to experience leg cramps prior to my daily dose of magnesium. Since taking this supplement every evening, I have no more issues. I really like Ancient Nutrients Magnesium and would highly recommend this brand.
Back Pain
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.8
USERS' SCORE
Good
Based on 1 Review
8.5
9
Vitamin D3 improves back pain
Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial.
Most Relevant Research
We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
8.8
Muscle pain relief
Most Useful Review
Perfect!!! I've been taking magnesium for about a month, and I've noticed significant improvement in muscle pain and a fair amount of improvement at the muscular level.
Chest Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Good
Based on 1 Review
8.5
8
Magnesium supplementation aids chest pain
The prevalence of hypomagnesaemia in pediatric patients with mitral valve prolapse syndrome and the effect of mg therapy.
Most Relevant Research
We explored the effects of magnesium treatment on chest pain in pediatric patients suffering from mitral valve prolapse syndrome. In our study involving 230 young participants, we defined hypomagnesaemia as having a serum magnesium level below 1.5 mg/dl.
After identifying 19 patients with insufficient magnesium levels—representing about 8.2% of the group—we treated them with an oral magnesium chloride supplement for five weeks. We were eager to see whether this would help alleviate symptoms, particularly chest pain.
After the treatment period, we observed that magnesium therapy provided statistically significant relief of chest pain for these patients. However, we did not find substantial improvements in other symptoms like palpitations, fatigue, and dyspnea. This finding is vital, as it indicates that while magnesium may play a role in easing chest pain, its overall benefit to other symptoms remains uncertain.
Overall, our study highlights the relatively low prevalence of magnesium deficiency in pediatric patients with mitral valve prolapse compared to adults. Nevertheless, we concluded that magnesium supplementation could be a beneficial approach to address specific symptoms like chest pain in this population.
After identifying 19 patients with insufficient magnesium levels—representing about 8.2% of the group—we treated them with an oral magnesium chloride supplement for five weeks. We were eager to see whether this would help alleviate symptoms, particularly chest pain.
After the treatment period, we observed that magnesium therapy provided statistically significant relief of chest pain for these patients. However, we did not find substantial improvements in other symptoms like palpitations, fatigue, and dyspnea. This finding is vital, as it indicates that while magnesium may play a role in easing chest pain, its overall benefit to other symptoms remains uncertain.
Overall, our study highlights the relatively low prevalence of magnesium deficiency in pediatric patients with mitral valve prolapse compared to adults. Nevertheless, we concluded that magnesium supplementation could be a beneficial approach to address specific symptoms like chest pain in this population.
8
Reduced frequency
Most Useful Review
I’ve noticed increased regularity since starting these. It’s been two to three weeks, and while they’re large capsules, I've adapted to taking them. I take them after workouts, and I researched magnesium due to experiencing random chest pain and muscle fatigue for months. Since then, my chest pain has significantly reduced in frequency and I'm slowly returning to upper body workouts.
Arthritis
SCIENTIFIC SCORE
Moderately Effective
Based on 26 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.3
8
Magnesium protects against bone erosion
Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study.
Most Relevant Research
We delved into the relationship between magnesium levels and gouty arthritis, a condition known for causing painful flare-ups and damaging joint function. Our research focused on measuring serum ionized magnesium levels in a group of 769 patients and assessing how these levels relate to bone erosion, a serious complication of gout.
Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.
Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.
Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.
Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.
6.8
Relieves arthritis pain
Most Useful Review
Magnesium is likely what you need. It helps with body aches and pains. This formula digests well and alleviates some finger arthritis. The Ancient Nutrition Formula also supports overall digestion and regularity. However, I’m unsure of the type of magnesium used, as it is not specified on the bottle or website.
Diarrhea
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.5
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
2
No significant benefit from vitamin D3
Vitamin D₃supplementation and childhood diarrhea: a randomized controlled trial.
Most Relevant Research
We conducted a thorough investigation into how vitamin D3 supplementation affects diarrhea in young children. The study involved 3,046 infants aged 1 to 11 months living in high-risk areas of Kabul, Afghanistan. They were randomly assigned to receive either six doses of vitamin D3 or a placebo over 18 months.
Our analysis measured instances of diarrhea, defined as having three or more loose stools in a single day. We focused on comparing the time to the first diarrhea episode and the risk of recurring episodes between both groups.
However, the results were quite clear: vitamin D3 supplementation did not lead to any significant reduction in the time before the first episode of diarrhea or in the likelihood of having recurrent diarrhea. The differences observed between the vitamin D3 group and the placebo group were not meaningful.
Despite our expectations, this study suggests that vitamin D3 supplementation doesn't provide the preventive benefits we were hoping for when it comes to diarrhea in this population. We recommend against using similar supplementation under comparable circumstances without further research.
Additional studies in other settings might help in understanding if vitamin D3 could play a beneficial role in preventing diarrhea elsewhere.
Our analysis measured instances of diarrhea, defined as having three or more loose stools in a single day. We focused on comparing the time to the first diarrhea episode and the risk of recurring episodes between both groups.
However, the results were quite clear: vitamin D3 supplementation did not lead to any significant reduction in the time before the first episode of diarrhea or in the likelihood of having recurrent diarrhea. The differences observed between the vitamin D3 group and the placebo group were not meaningful.
Despite our expectations, this study suggests that vitamin D3 supplementation doesn't provide the preventive benefits we were hoping for when it comes to diarrhea in this population. We recommend against using similar supplementation under comparable circumstances without further research.
Additional studies in other settings might help in understanding if vitamin D3 could play a beneficial role in preventing diarrhea elsewhere.
0
Caused severe illness
Most Useful Review
Do not purchase. This product did not suit me at all; I fell ill after taking just one capsule, resulting in particularly bad diarrhea. I’m relieved I didn't take the advised three capsules daily. I contacted Ancient Nutrients, which I believed to be a reputable company, but they were unhelpful and wouldn’t support this product with any recommendations. This turned out to be a waste of £24, and I wouldn’t recommend it to anyone. The seller refused a refund, leaving me questioning its authenticity.
