Supplement Facts
Serving Size: 4 capsules
Amount Per Serving
%DV
Vitamin D (as ergocalciferol)
10 mcg (400 I.U.)
50%
Calcium (as calcium hydroxyapatite, calcium citrate, calcium aspartate)†
1,000 mg
77%
Phosphorus (as calcium hydroxyapatite)†
500 mg
40%
Magnesium (as magnesium oxide, magnesium aspartate, magnesium citrate, magnesium taurinate)†
500 mg
119%
The product is found useful for the following medical conditions
Osteoporosis details
SCIENTIFIC SCORE
Possibly Effective
Based on 34 Researches
7.8
USERS' SCORE
Good
Based on 14 Reviews
8.8
9
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
10
Osteoporosis resolved
Most Useful Review
105 people found this helpful
After three years of using this product, I completely eliminated my osteoporosis. At 55, doctors claimed my condition resembled that of an 80-year-old. Instead of prescription medication, I opted for exercise and increased dietary calcium, and now, it’s entirely gone.
Leg Cramps details
SCIENTIFIC SCORE
Likely Ineffective
Based on 21 Researches
4.9
USERS' SCORE
Good
Based on 19 Reviews
8.6
9
Magnesium oxide treats leg cramps
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
10
Complete cramp relief
Most Useful Review
8 people found this helpful
Calcium magnesium does wonders for cramps! I suffered from excruciating cramps during my period for years. After starting this cal/mag supplement (2 in the morning, 2 at night), the results have been astounding! I haven't experienced a single leg cramp since I began. Without it, I would previously spend all day in bed with cramps. Now, I feel free to engage in daily activities!
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.5
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
9
Teeth health improved
Most Useful Review
2 people found this helpful
I regularly order this calcium product, probably for the sixth time now, as I really like it. The results are evident; my teeth no longer crumble, both for myself and my child.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.3
USERS' SCORE
Good
Based on 3 Reviews
8.5
0
We conducted a study to see if high-dose vitamin D3 could improve vascular health and reduce fatigue in individuals suffering from chronic fatigue syndrome (CFS). This was a well-structured trial involving 50 participants, all of whom met specific diagnostic criteria for CFS. Participants were divided into two groups: one received 100,000 units of vitamin D3 every two months, while the other received a placebo over a period of six months.
Despite a noticeable increase of 22 nmol/L in vitamin D levels for those who received the treatment compared to the placebo group, we found no significant benefits. There was no change in arterial stiffness, a key vascular health indicator, nor improvements in overall fatigue as measured by the Piper Fatigue scale.
In essence, our findings indicate that high-dose oral vitamin D3 does not offer the hoped-for relief in vascular function or fatigue for patients with chronic fatigue syndrome. This suggests that other therapeutic options may need to be explored for individuals suffering from this condition.
Despite a noticeable increase of 22 nmol/L in vitamin D levels for those who received the treatment compared to the placebo group, we found no significant benefits. There was no change in arterial stiffness, a key vascular health indicator, nor improvements in overall fatigue as measured by the Piper Fatigue scale.
In essence, our findings indicate that high-dose oral vitamin D3 does not offer the hoped-for relief in vascular function or fatigue for patients with chronic fatigue syndrome. This suggests that other therapeutic options may need to be explored for individuals suffering from this condition.
9
Better sleep quality
Most Useful Review
My husband takes these fast-absorbing tablets daily. He claims they have significantly improved his sleep and reduced his chronic fatigue syndrome, making him feel much better overall. They work best alongside good sleep and a healthy diet.
Irritable Bowel Syndrome details
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.5
9.5
We examined how vitamin D supplementation could help improve symptoms for those suffering from irritable bowel syndrome (IBS). This systematic review pulled together findings from four randomized, placebo-controlled trials, with a total of 335 participants, to determine the effectiveness of vitamin D on various IBS measures.
Participants with IBS often struggle with symptoms like pain and discomfort, and vitamin D deficiency has been frequently noted in these individuals. Our research indicated that taking vitamin D could lead to significant improvements in IBS severity compared to a placebo. The results showed that those receiving vitamin D reported notable changes in their IBS severity scores and quality of life scores after the supplementation.
Specifically, after taking vitamin D, participants fared much better in terms of symptom relief than those who received a placebo. While we found some variability in the overall effects on the total score of IBS, the positive outcomes in severity and quality of life were compelling. Overall, our findings suggest that vitamin D supplementation presents a promising option for managing IBS symptoms.
Participants with IBS often struggle with symptoms like pain and discomfort, and vitamin D deficiency has been frequently noted in these individuals. Our research indicated that taking vitamin D could lead to significant improvements in IBS severity compared to a placebo. The results showed that those receiving vitamin D reported notable changes in their IBS severity scores and quality of life scores after the supplementation.
Specifically, after taking vitamin D, participants fared much better in terms of symptom relief than those who received a placebo. While we found some variability in the overall effects on the total score of IBS, the positive outcomes in severity and quality of life were compelling. Overall, our findings suggest that vitamin D supplementation presents a promising option for managing IBS symptoms.
9
Better sleep overall
Most Useful Review
Excellent product! Taking four tablets every night before bed helps me achieve better sleep, and the magnesium aids my bowel movements.
Pelvic Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.3
USERS' SCORE
Good
Based on 3 Reviews
8.5
8
We evaluated how magnesium pidolate impacts primary dysmenorrhea in 30 young women. Over six menstrual cycles, we tracked their pain levels using a visual scale. Initially, no treatment was given, and subsequently, magnesium was administered just before menstruation.
The first day of menstrual pain showed a notable decrease with magnesium treatment, especially from the first to the sixth cycle. While there were some improvements on days two and three, those weren't statistically significant. Importantly, no side effects were reported, suggesting magnesium can be a reliable option for managing menstrual pain.
The first day of menstrual pain showed a notable decrease with magnesium treatment, especially from the first to the sixth cycle. While there were some improvements on days two and three, those weren't statistically significant. Importantly, no side effects were reported, suggesting magnesium can be a reliable option for managing menstrual pain.
9
Relieved cramps effectively
Most Useful Review
Thank you for such vitamins. I bought it for my mum for cramps. Local alternatives did not help, and she suffered greatly, particularly at night. It is heart-wrenching to see a mother in pain and feel helpless. Now, all is well. Thank you!!!
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.2
USERS' SCORE
Good
Based on 2 Reviews
8.4
8
High-dose vitamin D reduces anxiety
We conducted a study to understand how high-dose vitamin D supplementation might impact anxiety levels, particularly in patients experiencing post-COVID symptoms. In our double-blind, randomized controlled trial, we enrolled 80 individuals dealing with fatigue or neuropsychiatric issues after COVID-19.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
9
Effective for anxiety
Most Useful Review
I drink at night, and it works wonderfully; the anxiety in my legs has vanished, leading to a deep sleep.
Bone Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 8 Reviews
8.4
9
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
9
Excellent bone support
Most Useful Review
4 people found this helpful
COOL FROM COOL) A superb calcium from the Country Life brand, which many adore. An effective 1000mg calcium dosage per serving is in a highly absorbable "blended" form of hydroxyapatite and calcium chelates, ideal for musculoskeletal and joint issues. This form is optimal for strengthening teeth, with magnesium and 400 IU of Vitamin D3 aiding absorption. The large container lasts for two months; recommended intake is one capsule in the latter half of the day before bedtime for better absorption. It excels at maintaining the bone health of the elderly. I highly recommend it - may the power of iHerb be with you!! Yours, Tati.
Constipation details
SCIENTIFIC SCORE
Questionable
Based on 24 Researches
6.8
USERS' SCORE
Good
Based on 6 Reviews
8.2
9
We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
9
Consistent bathroom routine
Most Useful Review
Excellent! I manage to go to the toilet every morning after my meal. I was struggling with constipation, but now it's so good!
Heart Attack details
SCIENTIFIC SCORE
Questionable
Based on 35 Researches
6.4
USERS' SCORE
Good
Based on 2 Reviews
8.2
9
We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
7
Supports muscle function
Most Useful Review
Promotes calcium absorption, maintaining normal development and health of bones and teeth, and supporting normal contraction and nerve sensitivity of muscles and the heart.
Sleep Apnea details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.1
USERS' SCORE
Good
Based on 6 Reviews
8.2
7
We aimed to explore the connection between Vitamin D levels and excessive daytime sleepiness in patients diagnosed with obstructive sleep apnea (OSA). In this study, we analyzed serum Vitamin D levels in a group of newly diagnosed OSA patients, dividing them into two categories: those who experienced excessive daytime sleepiness (EDS) and those who did not.
Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.
Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.
Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
9
Sleep soundly
Most Useful Review
3 people found this helpful
Good sleep support. It helps me to sleep more soundly and I wake up feeling refreshed.
Nausea details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.8
8
Vitamin D and nausea in gastroparesis
We delved into an intriguing question: how do low vitamin D levels affect nausea in people experiencing gastroparesis, a condition that slows gastric emptying? By measuring the vitamin D levels of patients from the Gastroparesis Clinical Consortium Registry, we aimed to uncover the relationships between vitamin D, nausea, and gastric function.
Our findings revealed that over half of the patients had low vitamin D levels, specifically 56.1% of the 513 individuals studied. We observed a clear association between these low levels of vitamin D and increased experiences of nausea and vomiting. This was particularly notable in patients with delayed gastric emptying, where those with low vitamin D levels reported significantly more nausea.
While the study showed a correlation, it did not address whether supplementing with vitamin D could directly alleviate these symptoms. Instead, we found that lower vitamin D levels also related to a greater retention of food in the stomach after meals, which hints at a connection to gastric neuromuscular dysfunction. Overall, our study emphasized a noteworthy link between vitamin D and nausea but stopped short of confirming any direct treatment benefits.
Our findings revealed that over half of the patients had low vitamin D levels, specifically 56.1% of the 513 individuals studied. We observed a clear association between these low levels of vitamin D and increased experiences of nausea and vomiting. This was particularly notable in patients with delayed gastric emptying, where those with low vitamin D levels reported significantly more nausea.
While the study showed a correlation, it did not address whether supplementing with vitamin D could directly alleviate these symptoms. Instead, we found that lower vitamin D levels also related to a greater retention of food in the stomach after meals, which hints at a connection to gastric neuromuscular dysfunction. Overall, our study emphasized a noteworthy link between vitamin D and nausea but stopped short of confirming any direct treatment benefits.
9
No nausea experienced
Most Useful Review
This remedy does not induce nausea as the pharmacy "Nycomed" does. While some may prefer capsules, I favour the tablets from the same manufacturer. Each capsule contains 250 mg of calcium, making it easy to split the dosage. I appreciate the combination with magnesium, necessary for supporting the nervous system, alongside a small dose of Vitamin D. With a consistent intake, this drug has proven to be the best choice for me personally. It contains no sugar or unnecessary ingredients, which I find appealing. I take it with food due to a sensitive gastrointestinal tract. Highly recommended! This is my third time using it.
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 24 Researches
8.3
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.6
9
We observed a striking case involving a 76-year-old woman diagnosed with cervical cancer, who was treated with nedaplatin, a platinum-based chemotherapy drug. Shortly after starting her treatment, she experienced troubling symptoms, including numbness, dizziness, and a noticeable loss of appetite.
Upon investigation, we discovered low levels of calcium and magnesium in her blood, which were likely contributing to her symptoms. Thankfully, after administering intravenous calcium and magnesium, we saw a prompt improvement in both her mineral levels and her symptoms.
The case underscores the importance of monitoring electrolyte levels during chemotherapy treatments, such as nedaplatin. By focusing on these disturbances, healthcare providers can unveil potential diagnoses even when patients present with vague symptoms. Regular follow-ups during anticancer therapies could be crucial in effectively managing side effects such as dizziness.
Upon investigation, we discovered low levels of calcium and magnesium in her blood, which were likely contributing to her symptoms. Thankfully, after administering intravenous calcium and magnesium, we saw a prompt improvement in both her mineral levels and her symptoms.
The case underscores the importance of monitoring electrolyte levels during chemotherapy treatments, such as nedaplatin. By focusing on these disturbances, healthcare providers can unveil potential diagnoses even when patients present with vague symptoms. Regular follow-ups during anticancer therapies could be crucial in effectively managing side effects such as dizziness.
7.5
Improved dizziness
Most Useful Review
1 people found this helpful
Great! Firstly, it's a substantial dosage, which makes it easy to take. Despite being a large pill, I've found it easy to swallow. The ingredients are decent and quite suitable for my age group. I feel more energetic, and my dizziness appears to have improved.
