Doctor&#039;s Best Glucosamine Chondroitin MSM with OptiMSM

I'm delighted with this drug! Living with psoriatic arthritis has been difficult, especially as my hands once suffered immensely. After a year and a half of taking hormones and steroids, which caused side effects, I sought alternatives. Following a nutritionist's advice, I tried this supplement, and it truly works without any adverse effects. I'm ecstatic to feel relief!

Arthritis details

MSM improves knee osteoarthritis symptoms

Possibly Effective

Based on 14 Researches

Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2006;14:286.

We conducted a randomized, double-blind, placebo-controlled trial exploring the effects of methylsulfonylmethane (MSM) on knee osteoarthritis pain. Fifty adults aged 40 to 76 participated, taking either MSM or a placebo for 12 weeks.

While MSM did show improvements in pain and physical function, there was no significant effect on stiffness or overall symptom scores. This means that while MSM might help with certain aspects of osteoarthritis, the overall benefits and long-term safety need more research.

9.5

Knee pain relief

Most Useful Review

Mum had severe knee joint pain when walking, and after a month of taking chondroprotectors, the pain disappeared. I ordered different brands, and this one from NOW seemed most effective. For added efficiency, I also got Boswellia extract, which I highly recommend.

Athlete’s Foot details

Excellent! My left knee was injured and I hadn’t taken care of it. After turning 30, I struggled with pains while climbing stairs. After just three days of taking this, I noticed my feet were no longer sore. Now, after consuming two bottles, I find I don’t need to take it daily; just once or twice a week suffices, and I’m free of discomfort.

Back Pain details

Effective for pain relief

Worthy chondroprotector - recommended by my doctor. After taking these capsules during an arthrosis flare-up, my pain disappeared faster than usual. I've experienced more prolonged remissions since beginning this treatment. I even introduced my wife to it, and she found it effective too. I advise looking at the glucosamine and chondroitin dosage in other chondroprotectors, as this complex has an advantageous formula. I experienced no side effects and believe this product is suitable for ongoing use, especially for athletes and the elderly.

Cold Sores details

Great drug! I saw results from the first day of use. I take it with collagen, and the condition of my skin, hair, and nails has improved significantly; most importantly, my joints began to hurt less. I got it at a discount for 1512 rubles. Please give a like!

High Cholesterol details

My mum started taking this product for her joint pain. After two weeks, she noticed significant relief. She continues to take it regularly and no longer needs a walking aid. This supplement supports joint health by improving lubrication and mobility.

Pelvic Pain details

Effective joint relief

This was my first experience with this product. Initially sceptical, I started taking the capsules during a flare-up of my pelvic pain along with NSAIDs. To my surprise, the pain subsided much quicker than usual, leading me to continue taking the supplement. As my arthritis often flares up due to congenital issues, I noticed a significant improvement in my condition. I even decided to let my wife try it, as she suffers from her own joint pain. After two courses, both of us found the product effective and I now recommend it to my patients. With a solid dosage and no side effects, it can be a great help for those suffering from such conditions.

Rheumatoid Arthritis details

MSM and BA show limited effects

Notarnicola A, Tafuri S, Fusaro L, Moretti L, Pesce V, et al. The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis. Adv Ther. 2011;28:894. doi:10.1007/s12325-011-0068-3

In our clinical trial, we investigated the effects of methylsulfonylmethane (MSM) combined with boswellic acids (BA) on individuals suffering from knee arthritis, a chronic condition often characterized by joint pain and inflammation. We enrolled 60 participants who were randomly divided into two groups: one group received the MSM and BA treatment for 60 days, and the other group was given a placebo.

Over the follow-up periods of 2 and 6 months, we measured pain levels using a visual analog scale (VAS) and assessed joint function with the Lequesne index (LI). While we found that participants taking MSM and BA reported higher pain levels than those on the placebo after 2 months, these differences did not persist at the 6-month mark. Furthermore, when evaluating joint function, we noted no significant differences between the two groups.

However, one notable finding was that those receiving the combination treatment needed fewer anti-inflammatory drugs compared to the placebo group at both follow-up points. Despite the reduced reliance on these medications, we concluded that combined treatment with MSM and BA did not significantly improve pain or joint function compared to placebo.

8.8

Significant improvement

Most Useful Review

There is an effect - it works! I delayed writing a review as I wanted to observe the results. I ordered this drug for my mother-in-law, who has rheumatoid arthritis, and for my mother, suffering from intervertebral disc issues. Initially sceptical, they began taking the drug when pain forced them to agree. Within ten days, my mother-in-law noticed it was easier to rise from a chair, and the swelling in her knees diminished, though pain persisted. After two weeks, my mother could wake up on her side, something she hadn't managed due to back pain. They have now been taking the drug for over a month, and I'm reordering. They recommend it!

Sciatica details

No more back pain! This glucosamine product is brilliant! I take 2 capsules twice daily alongside a green smoothie with collagen, and my back pain is gone! After suffering from back pain and sciatica for many years, I feel so relieved and happy.

Bruise details

Effective for injuries

Great product! It resolves all issues related to bones, joints, bruises, and fractures exceptionally well! I use it regularly since someone in the family always has a problem. It has never let me down!

Cancer details

MSM anal cancer treatment feasibility

Questionable

Based on 3 Researches

Reynolds CW, Lieb W, Schecter A, Gaisa MM, McGill SK, et al. Piloting of a Screen‑Triage‑Treat Surgical Approach Model for Management of Anal Cancer in Liberia. Ann Glob Health. 2024;90:75. doi:10.5334/aogh.4576

We explored the challenges faced by men who have sex with men (MSM) regarding anal cancer treatment in Liberia. With limited access to screening and care for anal cancers, we aimed to investigate whether a screen-triage-treat approach could effectively help identify and manage anal high-grade squamous intraepithelial lesions (aHSIL) within this vulnerable population.

In our study, we collaborated with local organizations to gather data from MSM and transgender individuals. Participants were recruited and engaged in self-swabbing to test for high-risk human papillomavirus (HPV), alongside HIV testing. Those who tested positive for aHSIL were offered further evaluation and treatment using high-resolution anoscopy and infrared coagulation.

Among 110 participants, a significant number turned out to be living with HIV, and nearly half tested positive for high-risk HPV. This indicates a notable health concern. While 68% of those who tested positive opted for further procedures, we found that this model effectively presented a potential solution for identifying anal cancer risks and can work in a low-resource environment.

Overall, our findings suggest that implementing a screen-triage-treat model shows promise for reducing anal cancer incidence among MSM in Liberia. This approach, previously successful in cervical cancer management, might become a crucial tool in cancer prevention strategies for similar low- and middle-income countries.

9.5

Reduces cancer risk

Most Useful Review

Glucosamine sulfate is a simple sugar that prevents glucose oxidation. The dosage is critical; for an 80 kg person, 2000 mg daily can lead to heart issues and reduced lifespan if taken young. However, studies reveal that for those over 50, glucosamine is linked to a 41% lower risk of mortality from respiratory infections and a significant reduction in lung and colorectal cancer risks. Though I don’t take it as I’m still young, it provides my grandmother with crucial relief for her knees and potentially extends her life.

Chondromalacia Patella details

Recovery from injuries

This product is undoubtedly effective. As a running enthusiast for two years, I have dealt with numerous injuries, including chondromalacia and goose tendonitis. It allowed me to run again when walking was challenging due to these issues. I am unsure if it’s due to MSM or glucosamine/chondroitin, but now, my pain has completely vanished. I highly recommend it for anyone suffering from joint discomfort like myself.

Chronic Cough details

Effective joint treatment

I struggle with chronic joint issues, and after one course of taking collagen and glucosamine with chondroitin, the results have been very promising. Six months later, I plan to repeat the course for even better outcomes.

Chronic Fatigue Syndrome details

This product is definitely effective. I’ve dealt with meniscus damage, iliotibial band syndrome, and other injuries over the years. It enabled me to run again when walking was difficult due to chondromalacia and tendonitis. I’m unsure of the contributions from MSM, glucosamine, or chondroitin, but my pain has completely vanished, and I've sustained it with MSM. After my positive experience, I bought more to share with family and highly recommend it for anyone with joint pain.

Food Poisoning details

Improved joint mobility

A good preparation for joint support. Glucosamine aids in mobility, while chondroitin ensures lubrication. I take it daily with meals, and it effectively alleviates joint pain, improving both my joints and the condition of my nails and hair. I highly recommend it!

Heart Disease details

Excellent! Glucosamine is a natural substance in cartilage that prevents bone friction and alleviates pain and inflammation, while chondroitin aids in holding water, lubricating joints, and enhancing tissue elasticity. Methylsulfonylmethane (MSM), an organic sulphur compound, speeds up metabolism, and insufficient sulphur hampers nutrient absorption. This preparation is beneficial for fractures, joint pain, arthritis, rheumatism, and exercise-related issues, as well as brittle bones.

Migraine details

Likely Very Effective

Seng EK, Robbins MS, Nicholson RA. Acute migraine medication adherence, migraine disability and patient satisfaction: A naturalistic daily diary study. Cephalalgia. 2017;37:955. doi:10.1177/0333102416663459

MSM improves migraine management

We aimed to understand how adherence to migraine-specific medications (MSMs) influences migraine-related disability and patient satisfaction. Over three months, 337 participants used daily electronic diaries to track their migraine experiences, including the medications they took and their satisfaction with these treatments.

It was insightful to see that participants took their acute medications on a staggering 96.5% of the days they recorded migraines. Among the medications used, MSMs were the most common at 58%, followed by over-the-counter analgesics and opiates/barbiturates. We found that people tended to reach for medication when their pain was mild most often.

Our analysis showed that when individuals used MSMs during mild pain, they experienced the least daily disability and reported the highest satisfaction with their medications. This implies that using MSMs earlier, especially at the onset of milder symptoms, can significantly improve a patient's overall experience with migraines.

In conclusion, our study highlights the benefits of starting treatment with MSMs for better outcomes in managing migraine-related challenges and achieving greater satisfaction with acute medication usage.

9.5

Reduces migraine frequency

Most Useful Review

GREAT It normalises sleep with regular intake of 2 capsules. It improves my migraines significantly. When the special effects begin, I take my usual pills, add extra magnesium, and the migraine fades within a couple of hours, compared to the previous half-day disruption. The frequency has also decreased alongside medicinal support. Regular magnesium intake eases PMS and periods, so I remain calmer, and I can even go a day without painkillers. Chronic pain in my nasopharynx hardly worsens. I also take omega-3, serrapeptase, and resveratrol, but I believe magnesium plays a role. Taking magnesium, lecithin, and protein has shown a genuine effect with collagen. I was pleasantly surprised. No allergies, rashes, or digestive issues. Quality is excellent with natural ingredients.

Osteoporosis details

MSM enhances bone cell differentiation

Kim DN, Joung YH, Darvin P, Kang DY, Sp N, et al. Methylsulfonylmethane enhances BMP‑2‑induced osteoblast differentiation in mesenchymal stem cells. Mol Med Rep. 2016;14:460. doi:10.3892/mmr.2016.5274

We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.

Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.

Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.

9.5

Slows osteoporosis progression

Most Useful Review

Doctor's Best Glucosamine, Chondroitin, and MSM is a remarkable tool for aiding cartilage health. It slows bone resorption and enhances calcium retention, promoting bone tissue repair and inhibiting cartilage degeneration. Its topical application can slow osteoporosis progression and stimulate regeneration in connective tissues. I highly recommend it for managing joint pain and enhancing the normal physiological processes!

Psoriasis details

Psoriasis lesions vanished

I have been using it since April this year and am very pleased with the outcome, as my psoriasis lesions have disappeared and my mood has improved. The product's quality is excellent, containing great ingredients, and is gluten, soy, and milk-free, which suits my allergies. I really liked it.

Ptsd details

Improved joint health

Excellent! Glucosamine is used to prevent and treat osteoarthritis and helps regenerate cartilage tissue, has anti-inflammatory and chondroprotective effects. It helps to synthesise proteoglycans and hyaluronic acid in joint fluid, improves the joint capsule, and inhibits cartilage-destructive enzymes. With systemic use, glucosamine slows down osteoporosis, normalises hyaline exchange, stimulates cartilage regeneration, alleviates pain, and enhances quality of life. Methylsulfonylmethane aids in the removal of toxins and supports connective and cartilage tissue recovery, with noted improvement in post-traumatic recovery.

Stroke details

I love this product. Having developed after a stroke, I experience crunchy joints and noticeable stiffness and pain without any treatment. This glucosamine helps significantly; I notice a reduction in stiffness within two or three days of starting it. While the cartilage hasn't reduced, it feels somewhat softer, and the pain is much less pronounced. There are positive changes, including to my collagen.

Toothache details

Прекрасно! Even the toothache is gone! I strongly recommend it!

Anxiety details

MSM reduces anxiety in pregnancy

Horakova A, Kuklova M, Hrdlickova K, Nemcova H, Knytl P, et al. Effectiveness of the mom supports mom peer support intervention in treating antenatal mental health difficulties in women. Midwifery. 2024;139:104198. doi:10.1016/j.midw.2024.104198

We tested a phone-based peer support program called Mom Supports Mom (MSM) to see how it affects anxiety in pregnant women at risk of mental health issues. A total of 167 women participated in the study and were split into two groups. One group received the MSM intervention, while the other group continued with standard care, which didn’t include psychological support.

After one month, we checked in again on the women’s mental health using various assessment tools. While we found that levels of anxiety significantly dropped in the women who engaged in the MSM program, their depressive symptoms remained unchanged. Specifically, the anxiety levels showed a notable reduction, which suggests that the MSM support could help alleviate some of the stress and anxiety faced during pregnancy.

Additionally, we observed an increase in prenatal attachment among the women who received the peer support. This suggests that while MSM helps reduce anxiety, it may not address depression directly. Overall, the findings show promise for using peer support to aid mental well-being during pregnancy, though depression remains a challenge that needs further attention.

9.5

Manages joint pain

Most Useful Review

These miraculous vitamins, I’m not hesitant to call them that! After about a week of taking them, my knee pain decreased significantly, and my anxiety vanished entirely! I also bought them for my parents, whose joint pain from COVID improved remarkably, along with their anxiety.

Brain Tumor details

Significant pain relief

For many years, I endured pain in my back, knees, shoulders, and neck due to posterior cerebral palsy. Various treatments, including Western medicine and acupuncture, had minimal effect and greatly impacted my quality of life. After discovering that glucosamine might enhance joint mobility and reduce pain, I decided to try a well-reviewed product. To my delight, I've experienced seven months of pain relief, with a 90% reduction in knee pain. My shoulder and neck discomfort, which previously affected my brain's nerve function, has also vanished. This affordable solution means I no longer need costly medical treatments, and I highly recommend it to others experiencing similar pain.

Bursitis details

This really helps with tendonitis and bursitis! As a bassist in my late 40s, I began facing tendon and joint issues in my elbows and forearms, worsened by exercise. Following the supplement’s dosage has remarkably reduced soreness and improved my flexibility. I plan to remain a loyal user of this product and have been impressed with all items from this company.

Cardiovascular Disease details

Comprehensive joint care

I highly recommend this three-in-one supplement for joint protection. It contains MSM to relieve swelling, chondroitin sulfate for repairing cartilage, and amino sugar to lubricate joints. Made from natural shellfish sources, it is also friendly to cardiovascular health. With 360 capsules in one bottle, it's very cost-effective. For comprehensive care, consider combining it with additional ingredients for enhanced protection.

Chest Pain details

Pain and inflammation reduction

I’ve bought this for my sister for 2.5 years. She takes it twice daily alongside vitamin C. After the first course, her knee pain and inflammation improved significantly within three months, enhancing her joint mobility. Following this regimen, there were no side effects, and overall health improved, including nail strength and skin appearance. I definitely recommend this effective product for joint issues.

Depression details

The quality is excellent. There was a time when I felt dreadful, with pain in my spine and joints, high blood pressure, and persistent insomnia. My legs felt as though they were weighed down with ten-kilogram weights, and I often awoke at night due to muscle cramps. This led to a constant state of exhaustion and the question of my purpose in life. Depression began to set in. After starting on glucosamine, I noticed a surge of energy after two weeks and began to make plans once again, signalling that life was returning to normal.

Fibromyalgia details

THIS HAS SAVED THE DAY for my husband's sciatic nerve pain, allowing him to recover in two days! It also assists with my fibromyalgia and spine issues. I'm so grateful for this.

Hypothyroidism details

WORK 100%!!! At 50 and on hormone replacement therapy for hypothyroidism, I noticed significant pain in my legs by the end of the day. The pain felt like a tendon or nerve issue. Osteopathy was discovered through my analysis, revealing a middle stage of osteoporosis. After just one month of taking these supplements, I noticed a significant improvement. I recommend a three-month intake followed by a six-month break, especially for those with osteoporosis. I personally believe these dietary supplements work wonders for bone and joint issues!

Kidney Stones details

I purchased this for my partner’s persistent lower back pain, and within three days, he reported feeling better. I was hopeful for my own knee pain relief as well, and to my delight, he mentioned his knee also felt improved. Despite my aversion to medication, I've remained diligent in taking these daily, and I am pleased with the results.

Liver Disease details

This product effectively addresses various musculoskeletal pathologies and offers a good preventive effect. Chondroitin and glucosamine are well absorbed. Part of it is metabolised in the liver, but most reaches its intended site. MSM enhances cell membrane permeability, improving cellular nutrition and preventing catabolic reactions of muscle and bone tissue. The recommended daily doses for these substances vary. I initially bought this for prophylaxis but experienced an exacerbation of inflammation in my knee joint upon arrival. Relief came after three weeks of taking two capsules twice daily, allowing me to eventually reduce to one capsule twice daily. I have nearly forgotten about my knee pain and feel very satisfied.

Lupus details

Doctor's Best is a brand I trust for quality ingredients. I have been taking this supplement, along with others from various brands, for years to slow the deterioration of my joints and connective tissue due to lupus. It has worked well for me.

Mild Cognitive Impairment details

My mum's knees were hurting, and after several examinations, she was diagnosed with incipient arthritis. When she takes Glucosamine, she feels better; climbing stairs, sitting down, and long walks no longer cause her pain. That's why I always buy the maximum number of tablets.

Reflux details

So glad I found this brand. Excellent quality, very agreeable with my particular system and no acid reflux. Easy to ingest, and I am starting to feel better. Quality makes a difference; these are affordable. Also on auto-ship, which is really convenient, and I will continue with it.

Tinnitus details

This was effective for tinnitus. A physician informed me that chondroitin can help with tinnitus and hearing loss, prompting me to purchase it for a trial. I take 2 capsules in the morning and 2 in the evening. After 2 weeks, I hardly notice my tinnitus! It hasn't completely vanished, but it has lessened significantly, to the extent that I'm not consciously aware of it. I was initially doubtful, but I'm pleased I gave it a go!

Yeast Infection details

Significant improvement

My mother, aged 63, had long suffered from knee pain, making it difficult for her to climb stairs or even stand on a chair. After short walks, she experienced excruciating pain in her knee joints. Previous injections into the joint provided only temporary relief, and she was reluctant to repeat such procedures due to fears of infections. Despite using Terafleks and various ointments, she saw no benefit. However, after she began taking this supplement alongside collagen, Omega, and vitamin D3, she was overjoyed after two months, exclaiming, “I’ve forgotten about the ointment! I can walk and climb stairs again!" Initially sceptical, I decided to try it myself after seeing her results.

Blurred Vision details

Useful not only for the joints but also for the eyes. At 47 years old, I began taking hyaluronic acid with collagen and Doctor's Best Glucosamine Chondroitin MSM for my joints. I experienced issues with my eyes - rapid fatigue and stabbing pain. While awaiting my eye diagnosis, I took these supplements for 2 weeks. To my surprise, the pain and discomfort vanished, and the oculist found no issues during the vision test. The doctor merely prescribed moisturizing drops containing chondroitin sodium sulfate and sodium hyaluronate, explaining why my eyes were no longer painful.

Dizziness details

I have experienced improvements in my occupation pattern. The dizziness from anaemia has vanished, and my hands no longer ache when I wake up.

Insomnia details

Quality sleep attained

Glucosamine has a stabilising effect on insomnia, depression, and other conditions common in menopause or ageing. The ingredients are natural, relieving stress and improving brain function, concentration, and mood, while GABA enhances sleep quality, allowing for deeper and more effective rest.

Irritable Bowel Syndrome details

The effect was unexpected. I have suffered from irritable bowel syndrome for many years. After taking it, my condition improved slightly. It seems that collagen lines the intestines, reducing excessive sensitivity and irritation. I didn't notice any effect on my face.

Swollen Lymph Nodes details

This glucosamine-chondroitin complex is superb! It has a higher dosage than local alternatives. I felt noticeable improvements within 1.5 weeks of use. The effects are cumulative, hence patience is key, but it's worth it for pain-free movement without swelling. I'm delighted with this discovery from IHERB!

Adenoiditis details

Joint mobility enhanced

I recently started using Doctor's Best Glucosamine Chondroitin MSM with OptiMSM as part of my daily routine, and it's essential for my joint care. The blend of glucosamine, chondroitin, and MSM works well together to improve my joint mobility and flexibility. The easy-to-swallow capsules are smooth and glide down easily. This supplement, backed by a reputable brand, offers excellent value and has significantly contributed to my overall joint function. I highly recommend it to enhance joint health.

Heart Attack details

I bought this product for my mother due to her joint pain. After a month and a half, the pain has completely disappeared—thank goodness! Glucosamine sulfate helps with joint mobility, while chondroitin supports cartilage health and flexibility. MSM provides vital sulfur for overall health, benefiting her hair, skin, and nails as well.

Obesity details

She took her mother, aged 58, suffering from sore joints and obesity, and noticed that her pain diminished. If my review has been useful and interesting to you, please click the “YES” button. Wishing health and beauty to us all!

Sleep Apnea details

I could hardly walk due to terrible back and hip pain that kept me awake. After numerous ineffective prescriptions, I decided to try this product. Within a day, my pain significantly diminished, and in a few days, it completely vanished! I also noticed my nails and hair became stronger. This is truly a wonderful remedy!

Menopause details

Following menopause, I suffered from pain in my toes, fingers, and knees, which limited my mobility. After taking this supplement for about ten days, I noticed significantly less pain upon waking, which used to be the worst time. Bending and straightening my fingers has become much easier. While it’s not inexpensive, I would recommend it to anyone experiencing similar issues.

Ulcer details

Relieves various issues

Excellent! It alleviates leg ulcers, tiredness, fragile hair and nails, joint ulcers, swelling, nervousness, bone problems, and overall provides a beneficial effect.

Urinary Tract Infection details

Joint pain alleviated

Skin condition improvement

Eczema details

MSM (methylsulfonylmethane) is an organic compound containing sulphur that is often used as a supplement to enhance health. Here are the primary benefits of MSM: 1. Pain and Inflammation Relief: MSM can aid in reducing inflammation and pain, particularly in individuals with arthritis or other inflammatory conditions. 2. Joint Health Support: Taking MSM can enhance joint and ligament health by fostering cartilage repair and alleviating symptoms of osteoarthritis. 3. Skin Health Support: MSM is sometimes employed to enhance skin conditions, including acne and eczema, owing to its anti-inflammatory properties.

Gastritis details

Effective without discomfort

My mother, aged 60, received this product. The effects are cumulative and require at least two months of use. Despite her erosive gastritis, she experienced no discomfort or side effects from taking these capsules. After two weeks, she observed that her finger joints had straightened and joint pain had decreased. This drug is much cheaper than pharmacy alternatives while remaining effective.

Tendonitis details

A great supplement for those with joint problems! I began using this chondroprotector while tackling my back and knee pain. After just two weeks of taking these capsules, I felt no pain despite carrying my large baby. I will definitely order more and recommend it to others.

Blood Clot details

Heart protection mentioned

Glucosamine and chondroitin are essential for cartilage health. Combined with MSM, they enhance joint cartilage repair and mobility, preventing further deterioration. Additionally, this supplement supports heart health by reducing the risk of coronary disease and the formation of blood clots, while also inhibiting atherosclerotic plaques. The capsules are large, white, nearly odourless, and last for a minimum course of treatment.

Gout details

Moderately Effective

MSM shows promise for gout treatment

Qin DE, Liang W, Yu Y, Whelan EC, Yuan X, et al. Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway. J Ethnopharmacol. 2024;318:116906. doi:10.1016/j.jep.2023.116906

This study aimed to explore how Modified Simiaowan (MSM), a traditional six-herb formula, can help treat gouty arthritis (GA). We examined its effects on macrophages in the lab, as well as in animal models with induced gout. Using various techniques, we analyzed the inflammation response and the underlying biological pathways affected by MSM.

Through our research, we observed that MSM has strong anti-inflammatory and antioxidant properties. It seems to alleviate the symptoms of gouty arthritis by interacting with specific signaling pathways in the body, particularly the Nrf2/HO-1/ROS/NLRP3 pathway. This means that MSM not only reduces inflammation but also helps the body combat oxidative stress, which is significant in managing gout.

Overall, our findings suggest that MSM could be a promising natural solution for those struggling with gouty arthritis, providing relief through a multi-faceted approach to treatment. The study bridges traditional herbal remedies with modern scientific understanding, highlighting the potential benefits of integrating such treatments into healthcare for gout.

9.5

Knee recovery noted

Most Useful Review

Good super useful food supplement. My father enjoyed it for many years and always uses this brand. His knee, which was damaged by a gout attack and left him unable to walk, fully recovered within a month and has continued to improve since. Now it remains in a normal state.

Rash details

My husband has been taking this for 1.5 months. Initially, he took 2 capsules which caused a rash on his body. Despite issues with his knee, he hasn’t stopped taking it, simply adjusted the dosage to one capsule of Doctor's Best, Glucosamine Chondroitin MSM, and one of pure MSM. Thankfully, the rash has vanished. His joints are still a concern though.

Bloating details

I injured my neck, causing spine degeneration. A friend recommended this supplement, and it has worked remarkably well for me. It doesn’t cause bloating, and the tablet size is perfect.

Allergies details

Hewlings S, Kalman DS. Evaluating the Impacts of Methylsulfonylmethane on Allergic Rhinitis After a Standard Allergen Challenge: Randomized Double-Blind Exploratory Study. JMIR Res Protoc. 2018;7:e11139. doi:10.2196/11139

Likely Very Effective

MSM offers allergy symptom relief

We aimed to understand how methylsulfonylmethane (MSM) impacts symptoms of allergic rhinitis through a well-structured randomized, double-blind study.

Participants, who were prone to allergic responses, were tested after taking varying doses of MSM following allergen exposure.

Interestingly, the results showed that MSM significantly eased nasal symptoms and improved airflow, making it a potential alternative to conventional allergy medications.

We’re excited by the findings, as MSM appeared effective without common side effects associated with typical treatments.

8.8

Relieves skin allergies

Most Useful Review

MSM effectively alleviates pain and is safe for various inflamed conditions, including allergies. Doctors recommend it as a vital nutrient for skin, hair, and nails, and it assists in softening scar tissue and relieving muscle spasms.

Heartburn details

Does not cause heartburn. I bought it for my mother who previously used Teraflex, which caused her heartburn. We switched to Arthra, but it's rather pricey. So, we decided to try this product. We started with a small trial jar (120 tablets) and so far, all is well; the heartburn is gone. I plan to place a second order, this time for a larger quantity. I also took some for myself (as a precaution; I'm 44) – MSM without chondroitin and glucosamine.

Indigestion details

Less severe indigestion

A good digestive aid for the price! I've been facing moderate digestive issues, so the Basic Digest was a bit too mild for me. Since switching to this version, I've experienced less severe indigestion more infrequently, with no significant side effects.

Diarrhea details

Moderately Effective

MSM risk behaviors linked to diarrhea

Pérez-Tanoira R, Tamarit MDP, Montaña AMV, Carmena D, Köster P, et al. Increased Prevalence of Symptomatic Human Intestinal Spirochetosis in MSM with High-Risk Sexual Behavior in a Cohort of 165 Individuals. Trop Med Infect Dis. 2023;8. doi:10.3390/tropicalmed8050250

We explored the connections between human intestinal spirochetosis (HIS) and its symptoms, particularly diarrhea, in a group of individuals diagnosed at a tertiary hospital in Madrid. Our focus was on understanding how risky behaviors, especially among men who have sex with men (MSM), impact the prevalence of HIS and associated gastrointestinal issues.

In our review of 165 patients diagnosed with HIS, we found that most were male, with a significant majority identifying as MSM. Notably, a substantial portion of these individuals reported engaging in chemsex and unprotected oral-anal intercourse. Overall, 81.1% of patients were symptomatic, and diarrhea, notably the most common complaint (68.3%), raised concerns about the link between HIS and severe gastrointestinal distress.

Our analysis revealed that younger patients, particularly those under 41, had a higher likelihood of experiencing symptoms. Despite this, a high percentage (92.7%) had normal colonoscopy results. Interestingly, many patients also had previous or concurrent sexually transmitted diseases, which can complicate the diagnosis and treatment.

We observed that for symptomatic patients who did not have other gastrointestinal infections, treatment with metronidazole or doxycycline led to improvements. This highlights the importance of considering HIS as a potential cause of chronic diarrhea in MSM, especially after ruling out other conditions. Hence, we recommend this treatment approach for those exhibiting symptoms linked to HIS.

9.5

Diarrhea resolved

Most Useful Review

My mother, who has diabetes, suffered from diarrhea and could barely move. After consulting her doctor about the ingredients, he deemed it beneficial. Thankfully, after taking it, her diarrhea resolved, and she returned to her normal self. It's important to check ingredient lists before ordering to avoid allergies and ensure health benefits.

Ear Infection details

I purchased this for my dog who had a joint injury. After consulting our vet, we tried this complex. Within two weeks, her limping significantly improved. There were no allergic reactions, and it worked wonders for her!

Constipation details

The quality of this product is excellent, with great ingredients and an amazing taste. Everything about it is suitable, and I have yet to experience constipation – the intestinal lubrication is superb.

Diabetes details

The effect is noticeable! I ordered it for my mother, and her hip and knee joints began to trouble her much less when used with bosvelia and collagen. However, doctors warn against glucosamine for those with diabetes. Patients with cardiovascular issues, hypertension, or obesity should monitor cholesterol levels regularly while using this treatment.

Acne details

This supplement works wonders! I’ve noticed new hair growth, my skin has thickened, and the acne on my face has completely disappeared; my skin now glows. The visible results started appearing after two weeks, and to maintain these benefits, it’s essential to take it consistently for three months.

Headache details

Moderately Effective