NOW Supplements Vitamin B-12

Vitamin B12 aids shingles pain relief

Wang JY, Wu YH, Liu SJ, Lin YS, Lu PH. Vitamin B12 for herpetic neuralgia: A meta-analysis of randomised controlled trials. Complement Ther Med. 2018;41:277. doi:10.1016/j.ctim.2018.10.014

We conducted a review of randomized controlled trials to determine the effectiveness of vitamin B12 in treating postherpetic neuralgia (PHN), a painful condition following shingles. Our analysis included data from databases such as PubMed and Cochrane Library, focusing specifically on trials that measured pain relief outcomes.

Our findings indicate that vitamin B12 supplementation has a significant positive effect on reducing pain levels in PHN patients. In fact, those who received vitamin B12 experienced a notable decrease in pain compared to those on placebo, with a reduction in the pain score of about four points. This result suggests that vitamin B12 not only helps with pain relief but also enhances overall quality of life for individuals suffering from this distressing condition.

Additionally, we observed a drop in the number of patients relying on analgesics, pointing to a potential alternative treatment avenue with vitamin B12. Although the evidence is moderate in quality, it presents a compelling case for the use of vitamin B12 as a complementary therapy for managing pain associated with shingles.

Neurological relief

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10 people found this helpful

At 50, I wasn't aware my immune system had weakened, leading to Shingles. I experienced persistent neuralgia that hindered daily life. I was prescribed vitamin B12, Methycobal, along with antiviral medication. After discovering this product on iHerb, I bought it immediately after reading reviews praising its efficacy against neuralgia. Thankfully, it has alleviated my symptoms. The small lozenge has a pleasant berry and cherry flavour, and I took one after each meal. I highly recommend it.

Autism details

Erden S, Akbaş İleri B, Sadıç Çelikkol Ç, Nalbant K, Kılınç İ, et al. Serum B12, homocysteine, and anti-parietal cell antibody levels in children with autism. Int J Psychiatry Clin Pract. 2022;26:8. doi:10.1080/13651501.2021.1906906

Examining Vitamin B12 in Autism

We conducted a study that examined the levels of vitamin B12, homocysteine, and anti-parietal cell antibodies in children diagnosed with autism spectrum disorder (ASD) compared to a control group. Our research included 69 children, where 36 had ASD, and 33 were matched controls based on age, sex, and socioeconomic status. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS), while serum levels were measured using a common laboratory technique called enzyme-linked immunosorbent assay.

Our findings revealed that children with ASD had significantly lower levels of vitamin B12 and homocysteine compared to their peers in the control group. However, we found no significant difference in the levels of anti-parietal cell antibodies, which suggests that vitamin B12 deficiency may not be due to absorption issues related to these antibodies. While we observed notable micronutrient deficiencies, it’s important to clarify that the study did not establish a direct benefit of vitamin B12 treatment for autism symptoms.

Importantly, this research hints at the potential role that vitamin B12 deficiencies may play in the clinical features of autism. Nonetheless, we believe that further studies involving larger populations are necessary to better understand how these micronutrient levels might influence the condition and its underlying causes.

Improved academic skills

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147 people found this helpful

I have bought this product several times and really like it. My son, who has autism and doesn't speak, was advised by a psychiatrist to take methylcobalamin to enhance his cognitive function. Since starting this medication, he has excelled in his studies, particularly in mathematics. Although he began speaking at 8, by 10, his vocabulary had expanded significantly, which I believe is partly thanks to methylcobalamin.

Common Cold details

Improved general condition

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2 people found this helpful

Yes! I have been drinking this for a year. I do not suffer from the common cold and feel vigorous and active; my overall condition has improved.

Hypothyroidism details

Vitamin B12 and hypothyroid patients

Likely Ineffective

Based on 4 Researches

Chatterjee T, Gupta R, Choudhary S. A Study on Vitamin B12 Levels in Hypothyroid Patients Presenting to a Tertiary Care Teaching Hospital. J Assoc Physicians India. 2023;71:1.

We explored the connection between vitamin B12 deficiency and hypothyroidism through a focused study involving 100 hypothyroid patients. This research took place over a year and aimed to determine how common vitamin B12 deficiency is among these individuals and how it correlates with thyroid antibodies.

Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.

Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.

Essential for energy

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4 people found this helpful

Excellent! Vitamin B12 is indispensable for the body. It boosts haemoglobin, benefits heart muscle, aids in DNA synthesis, and supports energy production. As many of us suffer from anaemia, B12 is vital. I take at least 1000 mcg in methylated sublingual form, which is absorbed immediately. Living with hypothyroidism, it is essential for me, and I consume it regularly with meals, avoiding other vitamins.

Alzheimer details

Vitamin B12's limited effect on Alzheimer's

Lee CY, Chan L, Hu CJ, Hong CT, Chen JH. Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials. Aging (Albany NY). 2024;16:7856. doi:10.18632/aging.205788

We explored the potential role of vitamin B12, alongside folic acid, in slowing the progression of Alzheimer's disease (AD) through a meta-analysis of randomized control trials. Our aim was to determine whether these supplements might improve cognitive function, daily life activities, and influence blood homocysteine levels in individuals diagnosed with AD.

After carefully sifting through studies, we found five that met our criteria. These studies assessed the cognitive changes in participants through the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Additionally, they examined the impact on daily functioning as well as blood homocysteine levels.

The results showed that after six months of treatment, participants taking vitamin B12 and folic acid did experience a slight improvement in MMSE scores compared to those on a placebo. However, there was no significant change in the ADAS-Cog scores, which means some cognitive aspects didn’t show marked improvement. Likewise, daily life functioning did not see any benefits from the supplements.

Importantly, we also noted a significant reduction in blood homocysteine levels following the supplementation, suggesting a biochemical effect of the treatment. Overall, while vitamin B12 shows promise in enhancing some cognitive measures, it does not translate directly into broader cognitive or daily functioning improvements in Alzheimer's patients.

Supports neuron function

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9 people found this helpful

Unlike cyanocobalamin, methylcobalamin is a naturally occurring form of vitamin B12, more active and better absorbed in higher amounts. It aids neuronal lipid production, promotes axonal nerve regeneration, and has neuroprotective properties that enable neurons to function properly, thus assisting with Alzheimer’s disease, Parkinson’s disease, dementia, and neuropathic syndromes. A starting dose of 1000mcg is advisable, and it is considered non-toxic, as the body absorbs only what it needs—any excess is excreted. The tablets are small, pink, and sweet, and should be melted in the mouth rather than swallowed.

We observed an intriguing case involving a patient suffering from chest pain alongside severe anemia and vitamin B12 deficiency. The patient, a 44-year-old Hispanic woman, presented with escalating non-radiating chest pain, fatigue, and shortness of breath over three weeks. Her lab results showed critical pancytopenia and macrocytosis, raising concerns about a rare condition known as pseudo-thrombotic microangiopathy (TMA), which can occur due to vitamin B12 deficiency.

Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.

This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.

Chest pain resolved

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7 people found this helpful

I had sciatica for over six months, resulting in chest pain from my buttocks to my thighs. After starting B12 alongside vitamin D, I noticed significant improvement. Within three days, the pain disappeared. While my feet remain numb, I hope this will also improve. The tablets dissolve easily on the tongue; I find them effective and would recommend them for neuralgia.

Diabetes details

Zhou J, Ma H, Guan M, Feng J, Dong X, et al. Anti-inflammatory Fucoidan-ConA oral insulin nanosystems for smart blood glucose regulation. Int J Pharm. 2024;659:124250. doi:10.1016/j.ijpharm.2024.124250

Based on 11 Researches

Novel system lowers blood sugar

We explored a novel oral delivery system using vitamin B12, fucoidan, and concanavalin A to enhance insulin effectiveness for diabetes management. This smart nanosystem targets inflammation while regulating blood glucose levels efficiently. Our findings indicated that when tested on type I diabetic mice, the nanosystem significantly lowered blood sugar and reduced inflammatory markers, such as TNF-α and interleukin-6. Notably, the system ensures safe and effective delivery, presenting a promising alternative to traditional insulin methods.

Eliminated leg cramps

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3 people found this helpful

Excellent! The product is superb. I was suffering from leg cramps due to Glucophage, but after using it, my vitamin B12 levels increased, alleviating my cramps. Thank God.

Knee Pain details

7 people found this helpful

Sciatica plagued me for over six months, causing pain from my buttocks to my thighs. Other supplements helped, but a dull pain persisted. After just three days of taking B12, touted for neuralgia, the pain vanished! I've experienced numbness in my feet for some time and hope this will improve too. The tablets are small and can dissolve on the tongue; I take one daily, but up to two is fine. For anyone suffering from knee pain, this is worth a try!

Liver Disease details

Xu W, Wang Y, Cui S, Zheng Q, Lin Y, et al. Methylcobalamin protects against liver failure via engaging gasdermin E. Nat Commun. 2025;16:1233. doi:10.1038/s41467-024-54826-6

Based on 10 Researches

Methylcobalamin aids liver health

We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.

Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.

Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.

Supports liver health

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9 people found this helpful

Methylcobalamin, a natural form of vitamin B12, is better absorbed and retained in the body compared to synthetic cyanocobalamin. It aids in neuronal lipid production, nerve regeneration, and has properties that help with conditions like Alzheimer's and liver disease. At 1000mcg, the dose is safe and effective as any excess is excreted. The small, sweet tablets should be kept in the mouth until they melt for optimal absorption.

Rash details

My rash began to improve after I started taking enzymes; thankfully, the rash passed.

Ulcer details

Genetic insights into ulcer healing

Based on 6 Researches

Shah A, Khuba S, Kumar C S, Shanmukhaiah C, George M, et al. Phenotype puzzle: the role of novel LMBRD1 gene variant in Cbl deficiency causing Dyskeratosis Congenita-like clinical manifestations. J Hum Genet. 2025;70:207. doi:10.1038/s10038-025-01320-6

We delved into the complexities surrounding a specific genetic mutation in the LMBRD1 gene, which is linked to a variant form of cobalamin (vitamin B12) deficiency. This study highlighted a 15-year-old male with symptoms typical of Dyskeratosis Congenita, including skin hyperpigmentation and ulcers. After identifying a novel splice site deletion in the gene, we learned that this alteration can heavily impact vitamin B12 metabolism and lead to various clinical manifestations, including ulcers.

Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.

Quick healing

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1 people found this helpful

The taste is delicious, so be careful not to overindulge! Lol. My mouth ulcer heals quickly, so I always keep it on hand!

Bone Pain details

18 people found this helpful

I initially took this for peripheral nerve issues, but it surprisingly alleviated my lumbar pain too. After many hours of sitting at work, I experienced discomfort in my lower back and numbness in my left foot. I shifted to methylcobalamin for relief, and taking 10000 mcg daily greatly reduced my pain. I now take it twice a day, feeling amazed by the results.

Cardiovascular Disease details

Vitamin B status correlates with mortality

Based on 9 Researches

Li Y, Wang H, Chen S, Wei Q, Liu Y, et al. The combined indicator of vitamin B status calculated using 3-parameters (3cB) is negatively associated with mortality among US adults: NHANES 1999 to 2004. Nutr Res. 2025;136:53. doi:10.1016/j.nutres.2025.02.008

We examined the role of vitamin B status on mortality rates, focusing on cardiovascular disease. Using data from over 12,000 adults, we found that higher scores on the combined vitamin B status indicator (3cB) were linked to lower risks of dying from cardiovascular issues. Specifically, individuals with lower 3cB scores faced significantly higher risks of mortality. This suggests that maintaining adequate vitamin B levels could potentially play an important part in reducing cardiovascular disease-related deaths.

Enhances cardiovascular health

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6 people found this helpful

I trust the Now brand. I began supplementing my 83-year-old mother with methylcobalamin after consulting several doctors. It’s recommended for better absorption and aims to support her cardiovascular health, given her limited meat consumption.

Carpal Tunnel Syndrome details

Sato Y, Honda Y, Iwamoto J, Kanoko T, Satoh K. Amelioration by mecobalamin of subclinical carpal tunnel syndrome involving unaffected limbs in stroke patients. J Neurol Sci. 2005;231:13.

Based on 8 Researches

Vitamin B12 aids CTS recovery

We conducted a study to investigate the effects of mecobalamin, a form of vitamin B12, on carpal tunnel syndrome (CTS) in stroke patients. Our research involved a group of 135 stroke patients, with 67 receiving 1,500 micrograms of mecobalamin daily for two years, while the other 68 patients did not receive any treatment.

Remarkably, we found that many stroke patients exhibited greater abnormality in the nerve function of their nonparetic side (the side of the body not affected by stroke) compared to the hemiparetic side (the affected side). Before treatment began, nearly a third of both groups met the criteria for CTS.

Over the two years, those who took mecobalamin showed a significant improvement in sensory nerve responses when compared to the untreated group. We observed that even though both sensory and motor nerve functions improved, the sensory nerve functions in the treated patients improved more noticeably. Importantly, there were no reported side effects from the treatment, suggesting that oral mecobalamin could be a safe and beneficial option for managing CTS, especially in stroke patients.

No more numbness

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10 people found this helpful

No more finger numbness! I was diagnosed with Carpal Tunnel Syndrome and began searching for solutions, which led me to this supplement. After about a week of taking it, I noticed the numbness in my fingertips diminishing, and a month later, it has completely disappeared. It’s worth noting that the Carpal Tunnel Syndrome was relatively mild.

Cold Sores details

My daughter often suffers from cold sores, but her condition has improved after taking B12.

Ear Infection details

This supplement has helped alleviate my tinnitus. After a few weeks of taking it, the annoying cricket sounds in my ears have diminished significantly. It's sweet and enjoyable to take!

Allergies details

Vitamin B12 microneedles reduce inflammation

Based on 3 Researches

Guillot AJ, Martínez-Navarrete M, Giner RM, Recio MC, Santos HA, et al. Cyanocobalamin-loaded dissolving microneedles diminish skin inflammation in vivo. J Control Release. 2024;375:537. doi:10.1016/j.jconrel.2024.09.032

We investigated the potential of cyanocobalamin, or Vitamin B12, as a treatment for skin inflammation using a cutting-edge transdermal delivery system. The research focused on microneedle patches that effectively deliver this antioxidant form of Vitamin B12 into the skin.

Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.

However, it's important to note that while the results are promising, further studies are needed for broader applications.

Budget-friendly relief

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1 people found this helpful

Salvation for allergy sufferers. Most individuals are allergic to synthetic forms of group B. Methylcolbamine in this form is a true lifesaver. The tablets are small and sweet, best dissolved under the tongue. They are quite affordable compared to the Russian pharmaceutical market. I take them for three months with breaks and consider the company's B complex as well. For those with a persistent lack of time for proper nutrition—Salvation for allergies!

Irritable Bowel Syndrome details

Dietary guidance aids IBS management

Mazzawi T, Hausken T, Gundersen D, El-Salhy M. Effects of dietary guidance on the symptoms, quality of life and habitual dietary intake of patients with irritable bowel syndrome. Mol Med Rep. 2013;8:845. doi:10.3892/mmr.2013.1565

We examined how dietary guidance affects irritable bowel syndrome (IBS) symptoms and quality of life, particularly focusing on vitamin B12 intake. Our study involved 46 patients diagnosed with IBS based on established criteria, with 17 completing the entire program.

Through three sessions of personalized dietary advice, each lasting about 45 minutes, we found a significant reduction in IBS symptoms after the patients implemented the dietary changes. Their quality of life scores also improved notably. Although we noted an increase in vitamin B12 intake, it's important to emphasize that we did not isolate its effects from those of other dietary changes.

Interestingly, while our guidance helped patients enhance their overall nutrient intake, including vitamins and minerals, the increase in vitamin B12 specifically was the only change that reached statistical significance. However, we found no substantial differences in overall caloric or macronutrient intake among the participants.

In conclusion, while dietary guidance showed promising benefits for managing IBS symptoms and overall life quality, the impact of vitamin B12 alone remains unclear, as other dietary modifications may have played a role. Our findings suggest that individualized dietary counseling is a viable option in IBS management.

Fingertip relief

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10 people found this helpful

After suffering from carpal tunnel syndrome, I discovered this supplement. Within a week of taking it, the numbness in my fingertips reduced significantly, and a month later, it has completely vanished. The results might be due to the mild nature of my condition.

Nausea details

B12 treatment effective for pancytopenia

Choi E, Galicia Garcia G, Kishore Anna K, Albuja Altamirano MF, Yip L, et al. Vitamin B12 Deficiency Manifesting As Pancytopenia, Lymphadenopathy, and Fever: A Clinical Mimic of Hematologic Malignancies. Cureus. 2024;16:e64676. doi:10.7759/cureus.64676

We observed how vitamin B12 deficiency can masquerade as serious conditions like hematologic malignancies, causing symptoms such as dizziness, nausea, and leukopenia. In our evaluation of a 39-year-old male, we found that treating severe B12 deficiency led to significant improvement in his blood counts.

After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.

No nausea experienced

Most Useful Review

With a pleasant taste, I experienced no nausea after consuming this product. Its sublingual form boasts high bioavailability.

Pelvic Pain details

7 people found this helpful

Sciatica had been troubling me for over six months, causing pain from my buttocks to my thighs. Though improvements came with other supplements like vitamin D, a dull ache persisted. However, after just three days of taking B12, known for aiding neuralgia, my pain vanished! I've also experienced numbness in my feet for a while, which I'm hoping will improve. The tablets are small and dissolve quickly; I typically take one daily, but two seems acceptable. If you're experiencing pelvic pain, it's worth trying!

Anemia details

Di Sario F, Piloni F, Gasparini F, Serpetti E, Bruschi B, et al. Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy. Ital J Pediatr. 2024;50:186. doi:10.1186/s13052-024-01759-x

Based on 21 Researches

Effectiveness of B12 in IGS

We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.

This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.

Dizziness improved

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22 people found this helpful

My dizziness improved after taking B50 and B12 sublingually for a month. As I experience chronic dizziness and insomnia, I've found that combining these has helped significantly, making it easier to sleep without melatonin. I'm eager to see the results of my next blood test concerning my anemia.

Anxiety details

Nahar M, Rai R, Jat D. Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach. Int J Neurosci. 2024. doi:10.1080/00207454.2024.2398564

Based on 12 Researches

Vitamin B12 may reduce anxiety

We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.

The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.

Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.

7.5

Reduces anxiety effectively

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1 people found this helpful

I take it on an empty stomach in the morning, keeping it under the tongue for at least 20 minutes, as recommended. I've observed a reduction in anxiety and irritability, along with better memory and focus.

Cold details

Tamaddonfard E, Samadi F, Egdami K. The effects of vitamin B12 and diclofenac and their combination on cold and mechanical allodynia in a neuropathic pain model in rats. Vet Res Forum. 2013;4:19.

Based on 3 Researches

Vitamin B12 shows cold pain relief

We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.

In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.

As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.

7.5

Quick improvement

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3 people found this helpful

After surgery for neck stenosis, my hands and feet became numb and easily turned cold. However, after taking two tablets of Vitamin B12 1000mc daily, my condition began to improve within two to three days. I want to continue taking this.

Depression details

Laird EJ, O'Halloran AM, Molloy AM, Healy M, Hernandez B, et al. Low vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. Br J Nutr. 2023;130:268. doi:10.1017/S0007114521004748

Based on 21 Researches

Vitamin B affects depression risk

We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.

However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.

Strengthens memory

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10 people found this helpful

Forgetting information or people can indicate vitamin B12 deficiency. Adequate amounts support memory and are especially recommended for students. Research indicates that a deficiency raises the risk of developing Alzheimer's, highlighting its importance for brain health and focus. B12 may also benefit those prone to depression and mood disorders.

Flu details

Increased energy noted

Most Useful Review

1 people found this helpful

The packaging of the B12 pills is standard, with small, convenient sizes that are quite sweet and enjoyable to chew. I began taking them post-Covid, and I have seen noticeable benefits such as improved metabolism and a return of my sense of smell and taste. My energy levels soared, making me more active and engaged. I definitely recommend combining B12 with folic acid for better results.

Neuropathy details

B12 treatment improves neuropathy symptoms

Based on 15 Researches

Dekker MJHJ, Heerdink GC, Plattel CHM. Vitamin B12 Deficiency-Induced Neuropathy and Cognitive and Motor Impairment in the Elderly: A Case Study. Food Nutr Bull. 2024;45:S53. doi:10.1177/03795721241226886

We explored the effects of vitamin B12 deficiency on neurological health in elderly patients. In a case study involving two patients, we observed that even with normal B12 levels, symptoms like fatigue and cognitive impairment persisted, especially in those with significant medical histories.

Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.

Effective neuropathy relief

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4 people found this helpful

I purchased this as a countermeasure for my peripheral neuropathy, which makes my fingertips feel peculiar. It's been about 10 days since I started taking it, and it has worked so well that I've forgotten the discomfort in my fingertips.

Back Pain details

Mauro GL, Martorana U, Cataldo P, Brancato G, Letizia G. Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2000;4:53.

Based on 17 Researches

B12 alleviates low back pain

We evaluated the effectiveness of intramuscular vitamin B12 in treating low back pain among 60 patients aged 18 to 65 with mechanical pain lasting at least six months.

In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.

Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.

7.5

Pain relief

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26 people found this helpful

Hebaden is improving! After experiencing back pain due to Heberden's nodules during menopause, I discovered that B12 is effective. I took one tablet under my tongue morning and evening. After about a month, the pain in my fingers diminished significantly. My pinky still hurts, but overall I'm feeling better and intend to keep using it.

Chronic Fatigue Syndrome details

Wiebe E. N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports. Can Fam Physician. 1996;42:2214.

Vitamin B12 ineffective for CFS

We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.

In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.

These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.

Increased energy levels

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211 people found this helpful

Vitamin B12 is crucial for the body. I take it for my parents as they experience chronic fatigue syndrome. Since starting the supplements, they feel more active and less lethargic. We take it in courses and follow a break. The tablets are tiny and slightly sour. For optimal absorption, they need to dissolve completely.

Dizziness details

B12 treatment improved dizziness symptoms

Based on 17 Researches

Cittolin-Santos GF, Khalil S, Bakos JK, Baker K. Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic Anemia. Case Rep Hematol. 2020;2020:8697493. doi:10.1155/2020/8697493

We examined a unique case involving a 28-year-old male who experienced dizziness related to severe anemia from low vitamin B12 levels.

After treatment with daily vitamin B12 injections, his symptoms and lab values significantly improved, indicating a positive response to the treatment.

Despite the rare nature of his condition—seronegative pernicious anemia—the results suggest that B12 can effectively alleviate dizziness stemming from anemia in similar cases.

Energised and stable

Most Useful Review

18 people found this helpful

Following my gastrectomy, I was B12 deficient, experiencing daily dizziness. Within ten days of taking B12 with iron supplements, I felt significantly better. I can now stand without support, and I'm hopeful it will help with my grey hair.

Hair Loss details

1 people found this helpful

Following my endocrinologist's recommendation, I took this due to diagnosed anaemia. I observed that my blood pressure normalised, cholesterol decreased, and most notably, hair loss improved significantly while hair growth increased. Ferritin levels also rose markedly.

Leg Cramps details

3 people found this helpful

Excellent! This product is fantastic. I suffered from leg cramps due to Glucophage, but after using it, my vitamin B12 levels increased and I am free from suffering.

Mild Cognitive Impairment details

1 people found this helpful

Vitamin B12 is essential for brain function, energy production, and immune system support. This form, methylcobalamin, is highly absorbent and aids in myelin synthesis, crucial for nerve signalling. It also helps prevent cardiovascular disease and supports the health of red blood cells, guarding against anemia and potential cognitive decline.

Insomnia details

Chang HY, Sei H, Morita Y. Effects of intravenously administered vitamin B12 on sleep in the rat. Physiol Behav. 1995;57:1019.

Vitamin B12 promotes sleep in rats

We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.

During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.

Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.

7.5

Improved sleep quality

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22 people found this helpful

Anemia improved. I’m not vegan and have followed the Fujikawa theory for years, yet my MCV remains high and dizziness persisted. I’ve taken my usual B50 plus B12, dissolving it under my tongue as they are small. Since blood replaces every four months, I take three pills daily. After a month, my dizziness is lessened, and my insomnia has improved, allowing me to sleep easier without melatonin, which was an unexpected benefit. I look forward to my next blood test, as B12 seems to regulate the autonomic nervous system and sleep.

Sleep Apnea details

I appreciate the wonderful strawberry taste of these small sublingual pills. After being diagnosed with autoimmune atrophic gastritis, I bought them for my B12 deficiency. I've taken them for a few weeks, and I've noticed an improvement in my sleep, likely due to a combination of factors, including a diet of 80% raw foods and avoiding gluten, milk, and sugar.

Heart Attack details

Vitamin B12 shows no heart attack benefit

Likely Ineffective

Based on 2 Researches

Borowczyk K, Piechocka J, Głowacki R, Dhar I, Midtun Ø, et al. Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial. J Intern Med. 2019;285:232. doi:10.1111/joim.12834

In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.

Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.

Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.

Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.

Maintains heart health

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I take B12 for heart health, and I always choose Now Foods.

Frozen Shoulder details

2 people found this helpful

This product works well for my stiff shoulders and muscle pain. I enjoy the taste, which encourages me to keep using it.

Heart Disease details

Qin Y, Shi Y, Yu Q, Yang S, Wang Y, et al. Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway. Biomed Pharmacother. 2023;163:114761. doi:10.1016/j.biopha.2023.114761

Based on 10 Researches

B12 may help heart damage

We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.

Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.

Essential daily intake

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6 people found this helpful

Everyone needs vitamin B12 daily, as it supports numerous body functions. Symptoms of deficiency include fatigue and heart problems. I prefer Now Foods Methyl B-12 for its taste and effectiveness, especially since I avoid animal products.

High Cholesterol details

White button mushrooms reduce cholesterol

Based on 10 Researches

Jeong SC, Jeong YT, Yang BK, Islam R, Koyyalamudi SR, et al. White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nutr Res. 2010;30:49. doi:10.1016/j.nutres.2009.12.003

We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.

Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.

Supports cholesterol control

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3 people found this helpful

This excellent vitamin is essential for blood formation and nervous system health. It helps with fat burning and controlling cholesterol levels, making it especially important for vegetarians.

Migraine details

Vitamin B12 deficiency and migraines

Based on 11 Researches

Abdelsadek SE, Tahoun SA, Mansour FM, Abdulsalam MF, Ahmed AM. The correlation between vitamin B12 serum levels and migraine: a case-control study. Neurol Res. 2025;47:195. doi:10.1080/01616412.2025.2462735

We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).

Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.

This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.

Well absorbed

Most Useful Review

This product absorbed well in my body and is excellent for migraines.

Stroke details

Ge Y, Yang C, Zadeh M, Sprague SM, Lin YD, et al. Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice. iScience. 2024;27:109480. doi:10.1016/j.isci.2024.109480

Based on 16 Researches

Vitamin B12 aids stroke recovery

We explored the role of vitamin B12 in managing neuroinflammation after an ischemic stroke. Through preclinical studies, we observed that vitamin B12 effectively influenced microglial cells, which are key to the brain's immune response. This treatment promoted important cellular processes, leading to reduced brain damage and better neurological outcomes. However, when microglia were depleted before stroke, the positive effects of vitamin B12 disappeared. Overall, while vitamin B12 shows promise in enhancing recovery post-stroke, its impact hinges on these immune cells.

Life quality improvement

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Excellent! I frequently order from this site for my father-in-law, who has diabetes, hypertension, and previously had a stroke. The noticeable effect of these supplements combined has significantly improved his quality of life, alleviating many issues related to his blood vessels and nervous system.

Acne details

Vitamin B12 causes acne-like eruptions

Veraldi S, Benardon S, Diani M, Barbareschi M. Acneiform eruptions caused by vitamin B12: A report of five cases and review of the literature. J Cosmet Dermatol. 2018;17:112. doi:10.1111/jocd.12360

We observed five notable cases of acneiform eruptions linked to vitamin B12 in women aged 21 to 62. These eruptions manifested between one week and five months after starting vitamin B12 therapy.

The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.

Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.

Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.

Acne linked to dosage

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Don’t overdo it! I mistakenly took two per day initially, leading to breakouts. I suspected it was the cream, but when I stopped taking B12, the acne on my face immediately cleared up. I advise sticking to just one per day for short durations.

Tinnitus details

Dadgarnia M, Mandegari M, Zand V, Vaziribozorg S, Zare-Zardini H, et al. The effect of vitamin B12 on idiopathic tinnitus. Am J Otolaryngol. 2024;45:104028. doi:10.1016/j.amjoto.2023.104028

No significant benefit from B12

We conducted a double-blind clinical trial with 140 patients suffering from idiopathic tinnitus to gauge the effectiveness of vitamin B12. Participants were divided into two groups, one receiving vitamin B12 and the other a placebo over a month.

We evaluated tinnitus severity through questionnaires at multiple intervals. However, our findings revealed that vitamin B12 did not significantly reduce tinnitus severity compared to the placebo.

Ultimately, our study suggests that vitamin B12 may not be a beneficial treatment for tinnitus, as the results showed no noteworthy improvements.

7.5

Dizziness improvement

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11 people found this helpful

I purchased this after reading positive reviews regarding its effects on dizziness and tinnitus. Although it has only been a month, I noticed my dizziness has significantly reduced. I'm still observing the impact on my tinnitus, but my neuralgia has also improved, which is very encouraging.

Autoimmune Disorder details

Pernicious anemia diagnosis and treatment

Based on 15 Researches

Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4

We examined a case of a 51-year-old Ugandan man who experienced recurring lower limb weakness linked to pernicious anemia, an autoimmune condition causing vitamin B12 deficiency. After initial treatments, his symptoms reappeared, leading to further testing that confirmed the diagnosis.

Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.

Visible improvement

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4 people found this helpful

This product was just what I needed for my son's autoimmune disorder. I previously took vitamin B12 and methylfolate separately, but this combination proved more effective. Now Foods maintains high-quality standards, and I appreciate the small tablet size and pleasant cherry taste. After a week of use, I've noticed a significant difference, and I wholeheartedly recommend it.

Headache details