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Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
The product is found useful for the following medical conditions
Blood Clot
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
USERS' SCORE
Good
Based on 6 Reviews
8.9
8
Vitamin B12's role in clotting
Nitrous Oxide-Induced Cerebral Venous Thrombosis: A Case Report, Potential Mechanisms, and Literature Review.
Most Relevant Research
We observed a compelling case involving a 19-year-old female diagnosed with cerebral venous thrombosis (CVT) and intracerebral hemorrhage. This unusual situation stemmed from her history of nitrous oxide abuse, which led to a significant deficiency in vitamin B12. Nitrous oxide can interfere with vitamin B12's vital functions, particularly its role in breaking down homocysteine levels in the blood.
Our investigation revealed her serum vitamin B12 level was alarmingly low at less than 100 pg/mL, while her homocysteine levels soared to 100.6 µmol/L, far exceeding the normal range. After she began vitamin B12 supplementation, we were pleased to see her vitamin B12 levels return to normal, along with a drastic reduction in homocysteine.
This case highlights an essential connection: low vitamin B12 levels may contribute to hyperhomocysteinemia, which in turn could play a significant role in the formation of blood clots. While there were no other thrombophilia risk factors found, the evidence suggests that restoring vitamin B12 levels through supplementation can positively impact homocysteine levels and reduce the risk of clotting problems.
Overall, this finding underscores how important vitamin B12 is in maintaining healthy blood clotting mechanisms.
Our investigation revealed her serum vitamin B12 level was alarmingly low at less than 100 pg/mL, while her homocysteine levels soared to 100.6 µmol/L, far exceeding the normal range. After she began vitamin B12 supplementation, we were pleased to see her vitamin B12 levels return to normal, along with a drastic reduction in homocysteine.
This case highlights an essential connection: low vitamin B12 levels may contribute to hyperhomocysteinemia, which in turn could play a significant role in the formation of blood clots. While there were no other thrombophilia risk factors found, the evidence suggests that restoring vitamin B12 levels through supplementation can positively impact homocysteine levels and reduce the risk of clotting problems.
Overall, this finding underscores how important vitamin B12 is in maintaining healthy blood clotting mechanisms.
9.5
No more numbness
Most Useful Review
This is not just help; it’s a solution. My hands were occasionally numb, so the therapist sent me for a blood test for vitamin B12, which was low. After a month of taking the prescribed biological supplement, the problem disappeared and has not returned for half a year.
Cardiovascular Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 21 Reviews
8.8
8
Vitamin B12 reduces cardiovascular risks
Association of MTHFR C677T, MTHFRA1298C, and MTRRA66G Gene Polymorphisms with Hyperhomocysteinemia and Its Modulation by the Combined Effect of Vitamin B12 and Folate in Chinese Population with Hypertension.
Most Relevant Research
We explored the connection between vitamin B12, genetic factors, and cardiovascular health in a group of Chinese adults suffering from hypertension. By analyzing the genetic variations of individuals, we aimed to understand how these may influence levels of homocysteine, an amino acid that can impact heart health when present in high amounts.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
9.5
Enhances cardiovascular health
Most Useful Review
I trust the Now brand. I began supplementing my 83-year-old mother with methylcobalamin after consulting several doctors. It’s recommended for better absorption and aims to support her cardiovascular health, given her limited meat consumption.
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 45 Reviews
8.8
0
Vitamin B12 ineffective for CFS
N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.
Most Relevant Research
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
9
Increased energy levels
Most Useful Review
Vitamin B12 is crucial for the body. I take it for my parents as they experience chronic fatigue syndrome. Since starting the supplements, they feel more active and less lethargic. We take it in courses and follow a break. The tablets are tiny and slightly sour. For optimal absorption, they need to dissolve completely.
Hypothyroidism
SCIENTIFIC SCORE
Likely Ineffective
Based on 4 Researches
4.8
USERS' SCORE
Good
Based on 5 Reviews
8.8
7
Vitamin B12 and hypothyroid patients
A Study on Vitamin B12 Levels in Hypothyroid Patients Presenting to a Tertiary Care Teaching Hospital.
Most Relevant Research
We explored the connection between vitamin B12 deficiency and hypothyroidism through a focused study involving 100 hypothyroid patients. This research took place over a year and aimed to determine how common vitamin B12 deficiency is among these individuals and how it correlates with thyroid antibodies.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
9.5
Essential for energy
Most Useful Review
Excellent! Vitamin B12 is indispensable for the body. It boosts haemoglobin, benefits heart muscle, aids in DNA synthesis, and supports energy production. As many of us suffer from anaemia, B12 is vital. I take at least 1000 mcg in methylated sublingual form, which is absorbed immediately. Living with hypothyroidism, it is essential for me, and I consume it regularly with meals, avoiding other vitamins.
Anemia
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.8
USERS' SCORE
Good
Based on 43 Reviews
8.7
9
Vitamin B12 effectively treats anemia
An Unusual Case of Hemolytic Anemia: A Case Report.
Most Relevant Research
We observed a compelling case surrounding the impact of vitamin B12 on anemia, particularly in a 62-year-old man facing severe deficiencies due to factors like drug use, hepatitis C, smoking, and alcoholism. Initially, this patient presented with symptoms such as fatigue, fever, and confusion, raising concerns about more critical conditions like thrombotic thrombocytopenic purpura (TTP). Laboratory tests indicated severe pancytopenia and signs of hemolysis, making the situation quite alarming.
However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.
This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.
However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.
This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.
9.5
Dizziness improved
Most Useful Review
My dizziness improved after taking B50 and B12 sublingually for a month. As I experience chronic dizziness and insomnia, I've found that combining these has helped significantly, making it easier to sleep without melatonin. I'm eager to see the results of my next blood test concerning my anemia.
Back Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Good
Based on 22 Reviews
8.7
9
Vitamin B12 aids low back pain
Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.
Most Relevant Research
We conducted a thorough investigation to understand whether intramuscular vitamin B12 treatment could effectively relieve low back pain. This study was designed as a double-blind, placebo-controlled trial involving 60 patients aged 18 to 65 who suffered from mechanical low back pain or sciatic neuritis. Each participant had a history of back pain lasting from six months to five years and reported significant pain intensity according to a standard scale.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
8.8
Pain relief
Most Useful Review
Hebaden is improving! After experiencing back pain due to Heberden's nodules during menopause, I discovered that B12 is effective. I took one tablet under my tongue morning and evening. After about a month, the pain in my fingers diminished significantly. My pinky still hurts, but overall I'm feeling better and intend to keep using it.
Bone Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 28 Reviews
8.7
9.5
Alleviated back pain
Most Useful Review
I initially took this for peripheral nerve issues, but it surprisingly alleviated my lumbar pain too. After many hours of sitting at work, I experienced discomfort in my lower back and numbness in my left foot. I shifted to methylcobalamin for relief, and taking 10000 mcg daily greatly reduced my pain. I now take it twice a day, feeling amazed by the results.
Chest Pain
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8.7
8
Vitamin B12 improves chest pain
Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency.
Most Relevant Research
We observed an intriguing case involving a patient suffering from chest pain alongside severe anemia and vitamin B12 deficiency. The patient, a 44-year-old Hispanic woman, presented with escalating non-radiating chest pain, fatigue, and shortness of breath over three weeks. Her lab results showed critical pancytopenia and macrocytosis, raising concerns about a rare condition known as pseudo-thrombotic microangiopathy (TMA), which can occur due to vitamin B12 deficiency.
Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.
This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.
This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
9.5
Chest pain resolved
Most Useful Review
I had sciatica for over six months, resulting in chest pain from my buttocks to my thighs. After starting B12 alongside vitamin D, I noticed significant improvement. Within three days, the pain disappeared. While my feet remain numb, I hope this will also improve. The tablets dissolve easily on the tongue; I find them effective and would recommend them for neuralgia.
Depression
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
USERS' SCORE
Good
Based on 13 Reviews
8.7
2
Vitamin B12 shows no benefit for depression
Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis.
Most Relevant Research
We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
9.5
Strengthens memory
Most Useful Review
Forgetting information or people can indicate vitamin B12 deficiency. Adequate amounts support memory and are especially recommended for students. Research indicates that a deficiency raises the risk of developing Alzheimer's, highlighting its importance for brain health and focus. B12 may also benefit those prone to depression and mood disorders.
Dizziness
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.1
USERS' SCORE
Good
Based on 15 Reviews
8.7
9
Vitamin B12 improves dizziness symptoms
Acute presentation of dizziness in vitamin B12 deficient old patient of cardiac disease: a case report.
Most Relevant Research
We observed a fascinating case involving an elderly patient who experienced acute dizziness, ataxia, and imbalance shortly after receiving a pacemaker. Upon investigation, we discovered that her symptoms were linked to a significant deficiency in vitamin B12.
The patient's vitamin B12 levels were notably low, accompanied by increased plasma homocysteine and methylmalonic acid levels. Despite her neurological symptoms suggesting peripheral neuropathy, her brain scan returned normal results. What stood out to us was the absence of the typical hematological signs often associated with vitamin B12 deficiency.
Importantly, the patient responded remarkably well to treatment with parenteral vitamin B12, leading to a resolution of her dizziness. This case underscores the importance of considering vitamin B12 deficiency, especially in elderly patients who present with neuropsychiatric symptoms. As we reflected on this, it became clear that proper recognition and treatment of vitamin B12 deficiency can significantly influence patient outcomes.
The patient's vitamin B12 levels were notably low, accompanied by increased plasma homocysteine and methylmalonic acid levels. Despite her neurological symptoms suggesting peripheral neuropathy, her brain scan returned normal results. What stood out to us was the absence of the typical hematological signs often associated with vitamin B12 deficiency.
Importantly, the patient responded remarkably well to treatment with parenteral vitamin B12, leading to a resolution of her dizziness. This case underscores the importance of considering vitamin B12 deficiency, especially in elderly patients who present with neuropsychiatric symptoms. As we reflected on this, it became clear that proper recognition and treatment of vitamin B12 deficiency can significantly influence patient outcomes.
9.5
Energised and stable
Most Useful Review
Following my gastrectomy, I was B12 deficient, experiencing daily dizziness. Within ten days of taking B12 with iron supplements, I felt significantly better. I can now stand without support, and I'm hopeful it will help with my grey hair.
Common Cold
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Improved general condition
Most Useful Review
Yes! I have been drinking this for a year. I do not suffer from the common cold and feel vigorous and active; my overall condition has improved.
Knee Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
Pain relief achieved
Most Useful Review
Sciatica plagued me for over six months, causing pain from my buttocks to my thighs. Other supplements helped, but a dull pain persisted. After just three days of taking B12, touted for neuralgia, the pain vanished! I've experienced numbness in my feet for some time and hope this will improve too. The tablets are small and can dissolve on the tongue; I take one daily, but up to two is fine. For anyone suffering from knee pain, this is worth a try!
Liver Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.7
USERS' SCORE
Good
Based on 7 Reviews
8.6
9
Methylcobalamin aids liver health
Methylcobalamin protects against liver failure via engaging gasdermin E.
Most Relevant Research
We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
9.5
Supports liver health
Most Useful Review
Methylcobalamin, a natural form of vitamin B12, is better absorbed and retained in the body compared to synthetic cyanocobalamin. It aids in neuronal lipid production, nerve regeneration, and has properties that help with conditions like Alzheimer's and liver disease. At 1000mcg, the dose is safe and effective as any excess is excreted. The small, sweet tablets should be kept in the mouth until they melt for optimal absorption.
Pelvic Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
Pain relief noted
Most Useful Review
Sciatica had been troubling me for over six months, causing pain from my buttocks to my thighs. Though improvements came with other supplements like vitamin D, a dull ache persisted. However, after just three days of taking B12, known for aiding neuralgia, my pain vanished! I've also experienced numbness in my feet for a while, which I'm hoping will improve. The tablets are small and dissolve quickly; I typically take one daily, but two seems acceptable. If you're experiencing pelvic pain, it's worth trying!
Brain Tumor
SCIENTIFIC SCORE
Likely Ineffective
Based on 1 Research
4
USERS' SCORE
Good
Based on 1 Review
8.5
4
Vitamin B12's unclear impact on glioblastoma
Effect of pyridoxine or cobalamin supplementation on apoptosis and cell cycle progression in a human glioblastoma cell line.
Most Relevant Research
We explored the effects of vitamin B12 (cobalamin) supplementation on a human glioblastoma cell line known as U-87 MG. Our main goal was to understand how cobalamin, particularly in combination with pyridoxine (vitamin B6), influences cell viability and the process of cell death, known as apoptosis.
Our approach involved treating the glioblastoma cells with varying concentrations of vitamin B12 over a period of 24 to 72 hours. We assessed the health of the cells and their progression through the cell cycle using methods like spectrophotometry and flow cytometry. We also measured specific proteins associated with cell survival and death through western blot analysis.
We found that while vitamin B6 supplementation led to decreased cell viability and increased signs of apoptosis, the role of vitamin B12 was less clear. It appeared that cobalamin did not significantly enhance or inhibit cell death on its own. However, when combined with pyridoxine, it seemed to reduce the cytotoxic effects of vitamin B6.
In summary, while vitamin B12 in isolation did not show a direct benefit for the glioblastoma cells in our study, its potential to influence the effects of other vitamins highlights a complex interaction deserving of further exploration.
Our approach involved treating the glioblastoma cells with varying concentrations of vitamin B12 over a period of 24 to 72 hours. We assessed the health of the cells and their progression through the cell cycle using methods like spectrophotometry and flow cytometry. We also measured specific proteins associated with cell survival and death through western blot analysis.
We found that while vitamin B6 supplementation led to decreased cell viability and increased signs of apoptosis, the role of vitamin B12 was less clear. It appeared that cobalamin did not significantly enhance or inhibit cell death on its own. However, when combined with pyridoxine, it seemed to reduce the cytotoxic effects of vitamin B6.
In summary, while vitamin B12 in isolation did not show a direct benefit for the glioblastoma cells in our study, its potential to influence the effects of other vitamins highlights a complex interaction deserving of further exploration.
8.8
Nerve recovery noted
Most Useful Review
For neuralgia, I've been taking it since my brain tumour was removed. I feel my nerves are recovering well.
Ear Infection
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.5
9.5
Tinnitus relief
Most Useful Review
This supplement has helped alleviate my tinnitus. After a few weeks of taking it, the annoying cricket sounds in my ears have diminished significantly. It's sweet and enjoyable to take!
Gout
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Assists with gout
Most Useful Review
I took this supplement on my mother’s doctor’s advice due to her diabetes and nerve inflammation. Vitamin B12 is essential for nerves and is suitable for the elderly. It aids metabolism, digestion, and helps relieve gout symptoms. The taste is mild.
Irritable Bowel Syndrome
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 3 Reviews
8.5
8
Dietary guidance aids IBS management
Effects of dietary guidance on the symptoms, quality of life and habitual dietary intake of patients with irritable bowel syndrome.
Most Relevant Research
We examined how dietary guidance affects irritable bowel syndrome (IBS) symptoms and quality of life, particularly focusing on vitamin B12 intake. Our study involved 46 patients diagnosed with IBS based on established criteria, with 17 completing the entire program.
Through three sessions of personalized dietary advice, each lasting about 45 minutes, we found a significant reduction in IBS symptoms after the patients implemented the dietary changes. Their quality of life scores also improved notably. Although we noted an increase in vitamin B12 intake, it's important to emphasize that we did not isolate its effects from those of other dietary changes.
Interestingly, while our guidance helped patients enhance their overall nutrient intake, including vitamins and minerals, the increase in vitamin B12 specifically was the only change that reached statistical significance. However, we found no substantial differences in overall caloric or macronutrient intake among the participants.
In conclusion, while dietary guidance showed promising benefits for managing IBS symptoms and overall life quality, the impact of vitamin B12 alone remains unclear, as other dietary modifications may have played a role. Our findings suggest that individualized dietary counseling is a viable option in IBS management.
Through three sessions of personalized dietary advice, each lasting about 45 minutes, we found a significant reduction in IBS symptoms after the patients implemented the dietary changes. Their quality of life scores also improved notably. Although we noted an increase in vitamin B12 intake, it's important to emphasize that we did not isolate its effects from those of other dietary changes.
Interestingly, while our guidance helped patients enhance their overall nutrient intake, including vitamins and minerals, the increase in vitamin B12 specifically was the only change that reached statistical significance. However, we found no substantial differences in overall caloric or macronutrient intake among the participants.
In conclusion, while dietary guidance showed promising benefits for managing IBS symptoms and overall life quality, the impact of vitamin B12 alone remains unclear, as other dietary modifications may have played a role. Our findings suggest that individualized dietary counseling is a viable option in IBS management.
9.5
Fingertip relief
Most Useful Review
After suffering from carpal tunnel syndrome, I discovered this supplement. Within a week of taking it, the numbness in my fingertips reduced significantly, and a month later, it has completely vanished. The results might be due to the mild nature of my condition.
Chronic Cough
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.4
7
Effective for cough
Most Useful Review
I purchased this again at home, and it was very well received. The quality is excellent, with delicious honey-flavoured sweets that are beneficial for treating chronic cough. They're small in size, and the box is a lovely touch for convenient use. Perfect for any age!
Diabetes
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
USERS' SCORE
Good
Based on 10 Reviews
8.4
9
Vitamin B12 improves eye movements
The Effectiveness of Steroid Versus Vitamin Therapy in the Improvement of Extraocular Movements in Patients With Diabetic Cranial Nerve Palsy: A Comparative Study.
Most Relevant Research
We explored the effectiveness of vitamin B12 in treating diabetic ocular nerve palsy, a complication that can occur in people with diabetes. In a recent study, fifty individuals with this condition were divided into two groups. One group received steroid treatments while the other was treated with vitamin B12 injections.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
9.5
Eliminated leg cramps
Most Useful Review
Excellent! The product is superb. I was suffering from leg cramps due to Glucophage, but after using it, my vitamin B12 levels increased, alleviating my cramps. Thank God.
Frozen Shoulder
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.4
9.5
Effective relief
Most Useful Review
This product works well for my stiff shoulders and muscle pain. I enjoy the taste, which encourages me to keep using it.
Heart Disease
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.8
USERS' SCORE
Good
Based on 16 Reviews
8.4
9
Vitamin B12 helps heart recovery
Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.
Most Relevant Research
We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
9.5
Essential daily intake
Most Useful Review
Everyone needs vitamin B12 daily, as it supports numerous body functions. Symptoms of deficiency include fatigue and heart problems. I prefer Now Foods Methyl B-12 for its taste and effectiveness, especially since I avoid animal products.
Leg Cramps
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 20 Reviews
8.4
9.5
Cramps relief
Most Useful Review
Excellent! This product is fantastic. I suffered from leg cramps due to Glucophage, but after using it, my vitamin B12 levels increased and I am free from suffering.
Vertigo
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.4
9
Vitamin B12 enhances acupuncture effects
[Observation of therapeutic effects on cervical vertigo treated with different methods].
Most Relevant Research
We explored the effectiveness of various treatments for cervical vertigo, specifically focusing on different acupuncture methods and the inclusion of Vitamin B12 in one of the therapy combinations. In our study, ninety-one participants were divided into three groups: one receiving routine acupuncture, another using electroacupuncture, and a third receiving a combination of electroacupuncture and Vitamin B12 injections along with local anesthetics.
Each therapy was administered over twenty sessions within a month. We measured changes in blood flow in the vertebral and basilar arteries and evaluated the participants' symptoms and overall function related to their vertigo. While all treatment methods showed some positive effects, the combination therapy, which included Vitamin B12, stood out as being the most effective.
This suggests that Vitamin B12 might play a significant role alongside acupuncture methods in treating cervical vertigo. However, it’s important to note that the specific impact of Vitamin B12 alone wasn’t isolated in this study, leaving us to consider its effects within the broader context of combined therapies.
Each therapy was administered over twenty sessions within a month. We measured changes in blood flow in the vertebral and basilar arteries and evaluated the participants' symptoms and overall function related to their vertigo. While all treatment methods showed some positive effects, the combination therapy, which included Vitamin B12, stood out as being the most effective.
This suggests that Vitamin B12 might play a significant role alongside acupuncture methods in treating cervical vertigo. However, it’s important to note that the specific impact of Vitamin B12 alone wasn’t isolated in this study, leaving us to consider its effects within the broader context of combined therapies.
7.5
Dizziness resolved
Most Useful Review
I developed vertigo out of nowhere at the age of 65 and had been feeling dizzy upon waking. After consulting Dr Axe, I started taking B12, and within a week, my vertigo completely disappeared. Now, I take it every other day, as I was advised not to take it daily.
Cold Sores
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.3
7.5
Improved condition
Most Useful Review
My daughter often suffers from cold sores, but her condition has improved after taking B12.
Heart Attack
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
3
USERS' SCORE
Good
Based on 9 Reviews
8.3
4
Vitamin B12 shows no heart attack benefit
Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial.
Most Relevant Research
In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
8.3
Maintains heart health
Most Useful Review
I take B12 for heart health, and I always choose Now Foods.
High Cholesterol
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 16 Reviews
8.3
9.5
Supports cholesterol control
Most Useful Review
This excellent vitamin is essential for blood formation and nervous system health. It helps with fat burning and controlling cholesterol levels, making it especially important for vegetarians.
Tinnitus
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 21 Reviews
8.2
8.8
Dizziness improvement
Most Useful Review
I purchased this after reading positive reviews regarding its effects on dizziness and tinnitus. Although it has only been a month, I noticed my dizziness has significantly reduced. I'm still observing the impact on my tinnitus, but my neuralgia has also improved, which is very encouraging.
Headache
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 17 Reviews
8
8
Vitamin B12 deficiency linked to migraines
The correlation between vitamin B12 serum levels and migraine: a case-control study.
Most Relevant Research
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
9.5
Pain relief
Most Useful Review
I had a severe headache and symptoms similar to occipital neuralgia previously, leading me to seek hospital treatment. After being prescribed mecobalamin, my condition improved, so I purchased it here. I take it nightly, and it has significantly alleviated my headaches and improved my sleep quality.
Sleep Apnea
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.8
6.3
Improved sleep noted
Most Useful Review
I appreciate the wonderful strawberry taste of these small sublingual pills. After being diagnosed with autoimmune atrophic gastritis, I bought them for my B12 deficiency. I've taken them for a few weeks, and I've noticed an improvement in my sleep, likely due to a combination of factors, including a diet of 80% raw foods and avoiding gluten, milk, and sugar.
Autoimmune Disorder
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.8
USERS' SCORE
Moderately Good
Based on 18 Reviews
7.6
9
Pernicious anemia treatment effectiveness
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
Most Relevant Research
We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
9.5
Visible improvement
Most Useful Review
This product was just what I needed for my son's autoimmune disorder. I previously took vitamin B12 and methylfolate separately, but this combination proved more effective. Now Foods maintains high-quality standards, and I appreciate the small tablet size and pleasant cherry taste. After a week of use, I've noticed a significant difference, and I wholeheartedly recommend it.
