Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
The product is found useful for the following medical conditions
Shingles details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Good
Based on 4 Reviews
8.7
8
We conducted a review of randomized controlled trials to determine the effectiveness of vitamin B12 in treating postherpetic neuralgia (PHN), a painful condition following shingles. Our analysis included data from databases such as PubMed and Cochrane Library, focusing specifically on trials that measured pain relief outcomes.
Our findings indicate that vitamin B12 supplementation has a significant positive effect on reducing pain levels in PHN patients. In fact, those who received vitamin B12 experienced a notable decrease in pain compared to those on placebo, with a reduction in the pain score of about four points. This result suggests that vitamin B12 not only helps with pain relief but also enhances overall quality of life for individuals suffering from this distressing condition.
Additionally, we observed a drop in the number of patients relying on analgesics, pointing to a potential alternative treatment avenue with vitamin B12. Although the evidence is moderate in quality, it presents a compelling case for the use of vitamin B12 as a complementary therapy for managing pain associated with shingles.
Our findings indicate that vitamin B12 supplementation has a significant positive effect on reducing pain levels in PHN patients. In fact, those who received vitamin B12 experienced a notable decrease in pain compared to those on placebo, with a reduction in the pain score of about four points. This result suggests that vitamin B12 not only helps with pain relief but also enhances overall quality of life for individuals suffering from this distressing condition.
Additionally, we observed a drop in the number of patients relying on analgesics, pointing to a potential alternative treatment avenue with vitamin B12. Although the evidence is moderate in quality, it presents a compelling case for the use of vitamin B12 as a complementary therapy for managing pain associated with shingles.
10
Neurological relief
Most Useful Review
10 people found this helpful
At 50, I wasn't aware my immune system had weakened, leading to Shingles. I experienced persistent neuralgia that hindered daily life. I was prescribed vitamin B12, Methycobal, along with antiviral medication. After discovering this product on iHerb, I bought it immediately after reading reviews praising its efficacy against neuralgia. Thankfully, it has alleviated my symptoms. The small lozenge has a pleasant berry and cherry flavour, and I took one after each meal. I highly recommend it.
Updated: Mar 2026
Allergies details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 13 Reviews
8.6
8
We investigated the potential of cyanocobalamin, or Vitamin B12, as a treatment for skin inflammation using a cutting-edge transdermal delivery system. The research focused on microneedle patches that effectively deliver this antioxidant form of Vitamin B12 into the skin.
Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.
However, it's important to note that while the results are promising, further studies are needed for broader applications.
Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.
However, it's important to note that while the results are promising, further studies are needed for broader applications.
9
Budget-friendly relief
Most Useful Review
1 people found this helpful
Salvation for allergy sufferers. Most individuals are allergic to synthetic forms of group B. Methylcolbamine in this form is a true lifesaver. The tablets are small and sweet, best dissolved under the tongue. They are quite affordable compared to the Russian pharmaceutical market. I take them for three months with breaks and consider the company's B complex as well. For those with a persistent lack of time for proper nutrition—Salvation for allergies!
Updated: Mar 2026
Autism details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 5 Reviews
8.6
4
We conducted a study that examined the levels of vitamin B12, homocysteine, and anti-parietal cell antibodies in children diagnosed with autism spectrum disorder (ASD) compared to a control group. Our research included 69 children, where 36 had ASD, and 33 were matched controls based on age, sex, and socioeconomic status. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS), while serum levels were measured using a common laboratory technique called enzyme-linked immunosorbent assay.
Our findings revealed that children with ASD had significantly lower levels of vitamin B12 and homocysteine compared to their peers in the control group. However, we found no significant difference in the levels of anti-parietal cell antibodies, which suggests that vitamin B12 deficiency may not be due to absorption issues related to these antibodies. While we observed notable micronutrient deficiencies, it’s important to clarify that the study did not establish a direct benefit of vitamin B12 treatment for autism symptoms.
Importantly, this research hints at the potential role that vitamin B12 deficiencies may play in the clinical features of autism. Nonetheless, we believe that further studies involving larger populations are necessary to better understand how these micronutrient levels might influence the condition and its underlying causes.
Our findings revealed that children with ASD had significantly lower levels of vitamin B12 and homocysteine compared to their peers in the control group. However, we found no significant difference in the levels of anti-parietal cell antibodies, which suggests that vitamin B12 deficiency may not be due to absorption issues related to these antibodies. While we observed notable micronutrient deficiencies, it’s important to clarify that the study did not establish a direct benefit of vitamin B12 treatment for autism symptoms.
Importantly, this research hints at the potential role that vitamin B12 deficiencies may play in the clinical features of autism. Nonetheless, we believe that further studies involving larger populations are necessary to better understand how these micronutrient levels might influence the condition and its underlying causes.
9
Improved academic skills
Most Useful Review
147 people found this helpful
I have bought this product several times and really like it. My son, who has autism and doesn't speak, was advised by a psychiatrist to take methylcobalamin to enhance his cognitive function. Since starting this medication, he has excelled in his studies, particularly in mathematics. Although he began speaking at 8, by 10, his vocabulary had expanded significantly, which I believe is partly thanks to methylcobalamin.
Updated: Apr 2025
Blood Clot details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.9
USERS' SCORE
Good
Based on 3 Reviews
8.6
8
We examined a case involving a 56-year-old male who suffered from severe vitamin B12 deficiency. This deficiency led to dangerously high homocysteine levels, which are associated with blood clot formation. Despite effective treatment with B12, this case illustrates that vitamin deficiency can lead to significant health issues, including thrombosis and embolism.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
9
No more numbness
Most Useful Review
498 people found this helpful
This is not just help; it’s a solution. My hands were occasionally numb, so the therapist sent me for a blood test for vitamin B12, which was low. After a month of taking the prescribed biological supplement, the problem disappeared and has not returned for half a year.
Updated: Mar 2026
Common Cold details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Improved general condition
Most Useful Review
2 people found this helpful
Yes! I have been drinking this for a year. I do not suffer from the common cold and feel vigorous and active; my overall condition has improved.
Updated: Mar 2025
Rash details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Rash improved
Most Useful Review
My rash began to improve after I started taking enzymes; thankfully, the rash passed.
Updated: Mar 2026
Cardiovascular Disease details
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.7
USERS' SCORE
Good
Based on 5 Reviews
8.5
8
We examined the role of vitamin B status on mortality rates, focusing on cardiovascular disease. Using data from over 12,000 adults, we found that higher scores on the combined vitamin B status indicator (3cB) were linked to lower risks of dying from cardiovascular issues. Specifically, individuals with lower 3cB scores faced significantly higher risks of mortality. This suggests that maintaining adequate vitamin B levels could potentially play an important part in reducing cardiovascular disease-related deaths.
9
Enhances cardiovascular health
Most Useful Review
6 people found this helpful
I trust the Now brand. I began supplementing my 83-year-old mother with methylcobalamin after consulting several doctors. It’s recommended for better absorption and aims to support her cardiovascular health, given her limited meat consumption.
Updated: Mar 2026
Celiac details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.5
10
Significant B12 increase
Most Useful Review
4 people found this helpful
Think of an excellent vitamin! My son was never able to increase his B12 levels; after one month of using this vitamin, his levels went from 240 to 1,300. The doctor was amazed as he has celiac and can hardly take any chemical medications because of gluten and other substances in their composition. I rate it 100!
Updated: Apr 2025
Ear Infection details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Calmed symptoms
Most Useful Review
2 people found this helpful
I bought this after experiencing adverse symptoms like palpitations and stomach throbbing due to work stress, which disrupted my autonomic nervous system. After taking this B12 supplement, my symptoms improved significantly. I hope this helps others facing similar issues.
Updated: Mar 2026
Hypothyroidism details
SCIENTIFIC SCORE
Likely Ineffective
Based on 4 Researches
4.8
USERS' SCORE
Good
Based on 2 Reviews
8.5
7
We explored the connection between vitamin B12 deficiency and hypothyroidism through a focused study involving 100 hypothyroid patients. This research took place over a year and aimed to determine how common vitamin B12 deficiency is among these individuals and how it correlates with thyroid antibodies.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
9
Essential for energy
Most Useful Review
4 people found this helpful
Excellent! Vitamin B12 is indispensable for the body. It boosts haemoglobin, benefits heart muscle, aids in DNA synthesis, and supports energy production. As many of us suffer from anaemia, B12 is vital. I take at least 1000 mcg in methylated sublingual form, which is absorbed immediately. Living with hypothyroidism, it is essential for me, and I consume it regularly with meals, avoiding other vitamins.
Updated: Mar 2026
Anemia details
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.2
USERS' SCORE
Good
Based on 18 Reviews
8.4
9.5
We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
9
Improved energy levels
Most Useful Review
4 people found this helpful
I took vitamin B12 while following a meat-free diet due to my anemia, and it also helped with my iron deficiency anaemia. My levels of both iron and B12 were very low, but they are interrelated. I noticed an increase in both B12 and iron, along with raised ferritin. The key is to avoid taking them together, spacing them out instead.
Updated: Mar 2026
Blurred Vision details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.4
7.5
Improved vision
Most Useful Review
1 people found this helpful
It can enhance the vision of the eyes, and it is advisable to combine it with other health products.
Updated: Apr 2025
Carpal Tunnel Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.8
USERS' SCORE
Good
Based on 5 Reviews
8.4
9
We explored the effects of mecobalamin, a form of B12, on carpal tunnel syndrome (CTS) in patients who have experienced a stroke.
In our study, 67 stroke patients took 1500 mcg of mecobalamin daily for two years, while 68 others did not receive treatment.
Surprisingly, we found that the treated group showed significant improvements in nerve function on their nonparetic side compared to those who didn't receive the supplement. Sensory functions notably improved, and the treatment was found to be safe with no side effects.
This suggests that B12 can be a beneficial therapy for managing CTS post-stroke.
In our study, 67 stroke patients took 1500 mcg of mecobalamin daily for two years, while 68 others did not receive treatment.
Surprisingly, we found that the treated group showed significant improvements in nerve function on their nonparetic side compared to those who didn't receive the supplement. Sensory functions notably improved, and the treatment was found to be safe with no side effects.
This suggests that B12 can be a beneficial therapy for managing CTS post-stroke.
10
No more numbness
Most Useful Review
10 people found this helpful
No more finger numbness! I was diagnosed with Carpal Tunnel Syndrome and began searching for solutions, which led me to this supplement. After about a week of taking it, I noticed the numbness in my fingertips diminishing, and a month later, it has completely disappeared. It’s worth noting that the Carpal Tunnel Syndrome was relatively mild.
Updated: Mar 2026
Chest Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8.4
8
We observed an intriguing case involving a patient suffering from chest pain alongside severe anemia and vitamin B12 deficiency. The patient, a 44-year-old Hispanic woman, presented with escalating non-radiating chest pain, fatigue, and shortness of breath over three weeks. Her lab results showed critical pancytopenia and macrocytosis, raising concerns about a rare condition known as pseudo-thrombotic microangiopathy (TMA), which can occur due to vitamin B12 deficiency.
Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.
This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.
This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
9
Chest pain resolved
Most Useful Review
7 people found this helpful
I had sciatica for over six months, resulting in chest pain from my buttocks to my thighs. After starting B12 alongside vitamin D, I noticed significant improvement. Within three days, the pain disappeared. While my feet remain numb, I hope this will also improve. The tablets dissolve easily on the tongue; I find them effective and would recommend them for neuralgia.
Updated: Apr 2025
Diabetes details
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.9
USERS' SCORE
Good
Based on 5 Reviews
8.4
8
We explored a novel oral delivery system using vitamin B12, fucoidan, and concanavalin A to enhance insulin effectiveness for diabetes management. This smart nanosystem targets inflammation while regulating blood glucose levels efficiently. Our findings indicated that when tested on type I diabetic mice, the nanosystem significantly lowered blood sugar and reduced inflammatory markers, such as TNF-α and interleukin-6. Notably, the system ensures safe and effective delivery, presenting a promising alternative to traditional insulin methods.
9
Beneficial for diabetes
Most Useful Review
Vitamin B12 is known to be beneficial for diabetes.
Updated: Mar 2026
Knee Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.4
9
Pain relief achieved
Most Useful Review
7 people found this helpful
Sciatica plagued me for over six months, causing pain from my buttocks to my thighs. Other supplements helped, but a dull pain persisted. After just three days of taking B12, touted for neuralgia, the pain vanished! I've experienced numbness in my feet for some time and hope this will improve too. The tablets are small and can dissolve on the tongue; I take one daily, but up to two is fine. For anyone suffering from knee pain, this is worth a try!
Updated: Apr 2025
Menopause details
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Vitamin B12 may aid menopause relief
We observed the effects of a nutritional product that combined various ingredients, including vitamin B12, on menopausal symptoms. This study involved 156 menopausal women who took the product daily for 12 weeks and reported their symptoms using a validated scale.
After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.
However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.
After completing the study, we found significant reductions in various menopause-related issues. This included a substantial 45% decrease in depressive mood and a notable reduction of 48% in hot flashes. It's important to note that while vitamin B12 was included in the treatment, it was part of a broader combination with other beneficial ingredients.
However, we must clarify that the specific impact of vitamin B12 alone cannot be fully determined from this study. The results are promising for the product as a whole, showing effective relief from many menopausal symptoms, but further research is needed to isolate the role of vitamin B12 in managing these symptoms.
9
Pain relief achieved
Most Useful Review
10 people found this helpful
Due to menopause, I had numbness in my fingers, particularly in my index finger and thumb, which was quite painful. After researching, I discovered that B12 could be beneficial, but I struggled to find a standalone supplement in Japan, so I purchased it here. After starting the supplement, the pain disappeared, allowing me to open plastic bottle lids again. During severe episodes, I took it thrice daily after meals. I realised I was quite B12 deficient, so I bought more and keep it refrigerated as it melts easily.
Updated: Mar 2026
Alzheimer details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6
USERS' SCORE
Good
Based on 4 Reviews
8.3
4
We explored the potential role of vitamin B12, alongside folic acid, in slowing the progression of Alzheimer's disease (AD) through a meta-analysis of randomized control trials. Our aim was to determine whether these supplements might improve cognitive function, daily life activities, and influence blood homocysteine levels in individuals diagnosed with AD.
After carefully sifting through studies, we found five that met our criteria. These studies assessed the cognitive changes in participants through the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Additionally, they examined the impact on daily functioning as well as blood homocysteine levels.
The results showed that after six months of treatment, participants taking vitamin B12 and folic acid did experience a slight improvement in MMSE scores compared to those on a placebo. However, there was no significant change in the ADAS-Cog scores, which means some cognitive aspects didn’t show marked improvement. Likewise, daily life functioning did not see any benefits from the supplements.
Importantly, we also noted a significant reduction in blood homocysteine levels following the supplementation, suggesting a biochemical effect of the treatment. Overall, while vitamin B12 shows promise in enhancing some cognitive measures, it does not translate directly into broader cognitive or daily functioning improvements in Alzheimer's patients.
After carefully sifting through studies, we found five that met our criteria. These studies assessed the cognitive changes in participants through the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Additionally, they examined the impact on daily functioning as well as blood homocysteine levels.
The results showed that after six months of treatment, participants taking vitamin B12 and folic acid did experience a slight improvement in MMSE scores compared to those on a placebo. However, there was no significant change in the ADAS-Cog scores, which means some cognitive aspects didn’t show marked improvement. Likewise, daily life functioning did not see any benefits from the supplements.
Importantly, we also noted a significant reduction in blood homocysteine levels following the supplementation, suggesting a biochemical effect of the treatment. Overall, while vitamin B12 shows promise in enhancing some cognitive measures, it does not translate directly into broader cognitive or daily functioning improvements in Alzheimer's patients.
9
Prevents Alzheimer's onset
Most Useful Review
It effectively helps in preventing Alzheimer’s disease. I purchased it for my mother, and I believe it is beneficial.
Updated: Mar 2026
Cold Sores details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.3
7.5
Improved condition
Most Useful Review
My daughter often suffers from cold sores, but her condition has improved after taking B12.
Updated: Mar 2026
Ulcer details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.8
USERS' SCORE
Good
Based on 10 Reviews
8.3
9
We delved into the complexities surrounding a specific genetic mutation in the LMBRD1 gene, which is linked to a variant form of cobalamin (vitamin B12) deficiency. This study highlighted a 15-year-old male with symptoms typical of Dyskeratosis Congenita, including skin hyperpigmentation and ulcers. After identifying a novel splice site deletion in the gene, we learned that this alteration can heavily impact vitamin B12 metabolism and lead to various clinical manifestations, including ulcers.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
9
Quick healing
Most Useful Review
1 people found this helpful
The taste is delicious, so be careful not to overindulge! Lol. My mouth ulcer heals quickly, so I always keep it on hand!
Updated: Mar 2026
Heart Disease details
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.2
USERS' SCORE
Good
Based on 4 Reviews
8.2
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
9
Supports heart health
Most Useful Review
2 people found this helpful
I sought an effective way to support my energy and nervous system, and this vitamin B12 is perfect. The methylcobalamin boosts my energy levels, supports nerve health, and is easily absorbed. It also helps maintain metabolism and reduces homocysteine, important for heart disease. Its antioxidant properties support overall health, and regular use enhances my mood and well-being.
Updated: Mar 2026
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 15 Reviews
8.2
9
Cramps relief
Most Useful Review
3 people found this helpful
Excellent! This product is fantastic. I suffered from leg cramps due to Glucophage, but after using it, my vitamin B12 levels increased and I am free from suffering.
Updated: Mar 2026
Liver Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.7
USERS' SCORE
Good
Based on 5 Reviews
8.2
9
We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
7.5
Supports liver function
Most Useful Review
Vitamin B12 (methylcobalamin) is vital for energy metabolism and many biological processes. It is easily absorbed and supports both cardiovascular and nervous health. It may alleviate pain associated with peripheral nerve diseases and likewise has a beneficial impact on liver function, particularly in cases of liver disease.
Updated: Mar 2026
Neuropathy details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
USERS' SCORE
Good
Based on 18 Reviews
8.2
8
We explored the effects of vitamin B12 deficiency on neurological health in elderly patients. In a case study involving two patients, we observed that even with normal B12 levels, symptoms like fatigue and cognitive impairment persisted, especially in those with significant medical histories.
Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.
Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.
9
Effective neuropathy relief
Most Useful Review
4 people found this helpful
I purchased this as a countermeasure for my peripheral neuropathy, which makes my fingertips feel peculiar. It's been about 10 days since I started taking it, and it has worked so well that I've forgotten the discomfort in my fingertips.
Updated: Mar 2026
Pelvic Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.2
9
Pain relief noted
Most Useful Review
7 people found this helpful
Sciatica had been troubling me for over six months, causing pain from my buttocks to my thighs. Though improvements came with other supplements like vitamin D, a dull ache persisted. However, after just three days of taking B12, known for aiding neuralgia, my pain vanished! I've also experienced numbness in my feet for a while, which I'm hoping will improve. The tablets are small and dissolve quickly; I typically take one daily, but two seems acceptable. If you're experiencing pelvic pain, it's worth trying!
Updated: Mar 2026
Anxiety details
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.4
USERS' SCORE
Good
Based on 18 Reviews
8.1
8
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
7.5
Reduces anxiety effectively
Most Useful Review
1 people found this helpful
I take it on an empty stomach in the morning, keeping it under the tongue for at least 20 minutes, as recommended. I've observed a reduction in anxiety and irritability, along with better memory and focus.
Updated: Mar 2026
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 27 Reviews
8.1
0
Vitamin B12 ineffective for CFS
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
8
Increased energy levels
Most Useful Review
211 people found this helpful
Vitamin B12 is crucial for the body. I take it for my parents as they experience chronic fatigue syndrome. Since starting the supplements, they feel more active and less lethargic. We take it in courses and follow a break. The tablets are tiny and slightly sour. For optimal absorption, they need to dissolve completely.
Updated: Mar 2026
Depression details
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.9
USERS' SCORE
Good
Based on 4 Reviews
8.1
8
We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
7.5
Helps relieve depression
Most Useful Review
Excellent! This vitamin is part of the B complex and I believe this active form of B12 (methyl) is the best. After taking it, I noticed a relief in pain and depression. The sublingual gum tastes delightful, but it melted a bit in the heat when I had only a few tablets left.
Updated: Mar 2026
Stroke details
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
USERS' SCORE
Good
Based on 5 Reviews
8.1
8
We explored the role of vitamin B12 in managing neuroinflammation after an ischemic stroke. Through preclinical studies, we observed that vitamin B12 effectively influenced microglial cells, which are key to the brain's immune response. This treatment promoted important cellular processes, leading to reduced brain damage and better neurological outcomes. However, when microglia were depleted before stroke, the positive effects of vitamin B12 disappeared. Overall, while vitamin B12 shows promise in enhancing recovery post-stroke, its impact hinges on these immune cells.
9
Life quality improvement
Most Useful Review
Excellent! I frequently order from this site for my father-in-law, who has diabetes, hypertension, and previously had a stroke. The noticeable effect of these supplements combined has significantly improved his quality of life, alleviating many issues related to his blood vessels and nervous system.
Updated: Mar 2026
Attention Deficit Hyperactivity Disorder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 19 Reviews
8
9
Enhanced energy levels
Most Useful Review
1 people found this helpful
I was extremely deficient in vitamin B12, feeling lethargic and unmotivated. After learning more about its importance, I decided to buy B12 and noticed remarkable changes after just a week. My energy levels dramatically increased, and I feel active and alert now. I recommend taking enough water daily and consulting with a doctor before starting any supplements to ensure safety.
Updated: Mar 2026
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.4
USERS' SCORE
Good
Based on 11 Reviews
8
9.5
We examined a unique case involving a 28-year-old male who experienced dizziness related to severe anemia from low vitamin B12 levels.
After treatment with daily vitamin B12 injections, his symptoms and lab values significantly improved, indicating a positive response to the treatment.
Despite the rare nature of his condition—seronegative pernicious anemia—the results suggest that B12 can effectively alleviate dizziness stemming from anemia in similar cases.
After treatment with daily vitamin B12 injections, his symptoms and lab values significantly improved, indicating a positive response to the treatment.
Despite the rare nature of his condition—seronegative pernicious anemia—the results suggest that B12 can effectively alleviate dizziness stemming from anemia in similar cases.
9
Energised and stable
Most Useful Review
18 people found this helpful
Following my gastrectomy, I was B12 deficient, experiencing daily dizziness. Within ten days of taking B12 with iron supplements, I felt significantly better. I can now stand without support, and I'm hopeful it will help with my grey hair.
Updated: Mar 2026
Hair Loss details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 18 Reviews
8
9
Improved hair growth
Most Useful Review
1 people found this helpful
Following my endocrinologist's recommendation, I took this due to diagnosed anaemia. I observed that my blood pressure normalised, cholesterol decreased, and most notably, hair loss improved significantly while hair growth increased. Ferritin levels also rose markedly.
Updated: Mar 2026
Mild Cognitive Impairment details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 15 Reviews
8
9
Boosts brain health
Most Useful Review
1 people found this helpful
Vitamin B12 is essential for brain function, energy production, and immune system support. This form, methylcobalamin, is highly absorbent and aids in myelin synthesis, crucial for nerve signalling. It also helps prevent cardiovascular disease and supports the health of red blood cells, guarding against anemia and potential cognitive decline.
Updated: Apr 2025
Acne details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.6
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.9
9.5
We observed five notable cases of acneiform eruptions linked to vitamin B12 in women aged 21 to 62. These eruptions manifested between one week and five months after starting vitamin B12 therapy.
The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.
Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.
Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.
The primary symptoms consisted of papules and pustules appearing mainly on the face. In three of the patients, these skin issues also extended to areas like the neck, shoulders, chest, and upper back, but interestingly, there were no signs of comedones or cysts.
Out of the five women, two had particularly high levels of vitamin B12 in their blood. A closer look at one patient's skin under a microscope revealed eosinophilic folliculitis, a type of inflammation in hair follicles. Fortunately, all patients experienced spontaneous and complete recovery within three to six weeks after stopping vitamin B12 treatment.
Overall, while vitamin B12 did not provide a benefit for acne treatment, it highlighted an unusual side effect of acne-like symptoms in these cases.
7
Less acne observed
Most Useful Review
2 people found this helpful
The effect is quick; I have three times fewer acne spots than before. I had no energy previously, but after taking the pastilles, which are quite tasty, I struggled to avoid exceeding the daily limit. It’s crucial to stick to the dosage to avoid side effects like cardiac arrhythmia and strange sensations in my head.
Updated: Apr 2026
Insomnia details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.7
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.9
8
Vitamin B12 promotes sleep in rats
We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
7.5
Improved sleep quality
Most Useful Review
22 people found this helpful
Anemia improved. I’m not vegan and have followed the Fujikawa theory for years, yet my MCV remains high and dizziness persisted. I’ve taken my usual B50 plus B12, dissolving it under my tongue as they are small. Since blood replaces every four months, I take three pills daily. After a month, my dizziness is lessened, and my insomnia has improved, allowing me to sleep easier without melatonin, which was an unexpected benefit. I look forward to my next blood test, as B12 seems to regulate the autonomic nervous system and sleep.
Updated: Mar 2026
Sleep Apnea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.9
7.5
Improved sleep noted
Most Useful Review
I appreciate the wonderful strawberry taste of these small sublingual pills. After being diagnosed with autoimmune atrophic gastritis, I bought them for my B12 deficiency. I've taken them for a few weeks, and I've noticed an improvement in my sleep, likely due to a combination of factors, including a diet of 80% raw foods and avoiding gluten, milk, and sugar.
Updated: Mar 2025
Flu details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 19 Reviews
7.8
9
Increased energy noted
Most Useful Review
1 people found this helpful
The packaging of the B12 pills is standard, with small, convenient sizes that are quite sweet and enjoyable to chew. I began taking them post-Covid, and I have seen noticeable benefits such as improved metabolism and a return of my sense of smell and taste. My energy levels soared, making me more active and engaged. I definitely recommend combining B12 with folic acid for better results.
Updated: Mar 2026
Cold details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.7
8
We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.
As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.
8
Quick improvement
Most Useful Review
3 people found this helpful
After surgery for neck stenosis, my hands and feet became numb and easily turned cold. However, after taking two tablets of Vitamin B12 1000mc daily, my condition began to improve within two to three days. I want to continue taking this.
Updated: Mar 2026
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.6
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.6
9
We examined a case of a 51-year-old Ugandan man who experienced recurring lower limb weakness linked to pernicious anemia, an autoimmune condition causing vitamin B12 deficiency. After initial treatments, his symptoms reappeared, leading to further testing that confirmed the diagnosis.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
9
Reduced homocysteine
Most Useful Review
1 people found this helpful
I purchased this vitamin as some individuals have a gene that prevents the absorption of ordinary folic acid, hence they require metafolins. Along with methyl-cobalamin for enhanced effect, I noticed a reduction in my elevated homocysteine level to 5 after taking metafolin and methyl-B12 once daily. The taste is pleasant and dissolves quickly.
Updated: Mar 2026
Frozen Shoulder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.6
7.5
Improved flexibility
Most Useful Review
10 people found this helpful
I experienced heavy sensations in my buttocks, thighs, and calves due to sciatica, but painkillers were ineffective. After a week of taking this small, slightly sweet tablet, I began to feel better, and by ten days, I no longer needed a compress. The dullness greatly improved, and my stiff shoulders felt relieved. It's a product I wish to keep stocked!
Updated: Mar 2026
Migraine details
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.2
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.6
7
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
9
Well absorbed
Most Useful Review
This product absorbed well in my body and is excellent for migraines.
Updated: Apr 2025
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.2
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.5
8
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
9
Pain relief
Most Useful Review
13 people found this helpful
I had a severe headache and symptoms similar to occipital neuralgia previously, leading me to seek hospital treatment. After being prescribed mecobalamin, my condition improved, so I purchased it here. I take it nightly, and it has significantly alleviated my headaches and improved my sleep quality.
Updated: Apr 2026
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.5
9
We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
9
Supports cholesterol control
Most Useful Review
3 people found this helpful
This excellent vitamin is essential for blood formation and nervous system health. It helps with fat burning and controlling cholesterol levels, making it especially important for vegetarians.
Updated: Mar 2026
Tinnitus details
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
5.4
USERS' SCORE
Moderately Good
Based on 20 Reviews
7.5
1
We conducted a double-blind clinical trial with 140 patients suffering from idiopathic tinnitus to gauge the effectiveness of vitamin B12. Participants were divided into two groups, one receiving vitamin B12 and the other a placebo over a month.
We evaluated tinnitus severity through questionnaires at multiple intervals. However, our findings revealed that vitamin B12 did not significantly reduce tinnitus severity compared to the placebo.
Ultimately, our study suggests that vitamin B12 may not be a beneficial treatment for tinnitus, as the results showed no noteworthy improvements.
We evaluated tinnitus severity through questionnaires at multiple intervals. However, our findings revealed that vitamin B12 did not significantly reduce tinnitus severity compared to the placebo.
Ultimately, our study suggests that vitamin B12 may not be a beneficial treatment for tinnitus, as the results showed no noteworthy improvements.
7.5
Dizziness improvement
Most Useful Review
11 people found this helpful
I purchased this after reading positive reviews regarding its effects on dizziness and tinnitus. Although it has only been a month, I noticed my dizziness has significantly reduced. I'm still observing the impact on my tinnitus, but my neuralgia has also improved, which is very encouraging.
Updated: Mar 2026
Nausea details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.2
9
We observed how vitamin B12 deficiency can masquerade as serious conditions like hematologic malignancies, causing symptoms such as dizziness, nausea, and leukopenia. In our evaluation of a 39-year-old male, we found that treating severe B12 deficiency led to significant improvement in his blood counts.
After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.
After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.
9
No nausea experienced
Most Useful Review
With a pleasant taste, I experienced no nausea after consuming this product. Its sublingual form boasts high bioavailability.
Updated: Mar 2026
Data last updated:
