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Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Lactoferrin (as Apolactoferrin) 
250 mg

The product is found useful for the following medical conditions

Anemia

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Good
Based on 115 Reviews
8.9
9
Pediatric anemia treatment evaluation
Oral lactoferrin as a treatment of pediatrics' anemia resulted from chronic kidney diseases: a randomized controlled trial.
Most Relevant Research
We explored an important question regarding anemia management in children with chronic kidney disease (CKD). In a randomized clinical trial, we compared the effectiveness of oral lactoferrin and intravenous iron dextran in treating anemia related to CKD in pediatrics.

The study involved 60 children who were divided into two groups: one received 100 mg of oral lactoferrin daily for three months, while the other group was treated with IV iron dextran three times a week. After the treatment period, we observed significant changes in several blood parameters among those taking oral lactoferrin, specifically in hemoglobin, red blood cells, and various other indicators related to anemia.

However, while both treatments proved effective, we found no significant differences between the two groups overall in improving anemia symptoms after three months. Ultimately, while oral lactoferrin showed promising results, it did not outperform IV iron dextran to a degree that would change treatment choices.
9.5
Ferritin has risen
Most Useful Review
I am truly grateful that I discovered Lactoferrin! I have chronic anaemia and struggled to increase my ferritin levels. After ceasing iron supplements, my ferritin dropped to 3. Thankfully, Lactoferrin raised it to 56! My health has greatly improved; my depression has lifted, my sleep quality has enhanced, and I've gained warmth in my limbs. This supplement has remarkable properties against various viruses and aids in cell oxygenation, boosting stamina and recovery from illness.

Ear Infection

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.8
9.5
Significant health recovery
Most Useful Review
My employee suffered from severe kidney and liver infections, which seemed unmanageable until she started taking lactoferrin. By increasing her dosage, she saw notable improvements in her condition, including reduced pain and energy restoration.

Eye Infection

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.8
9.5
Significant improvement
Most Useful Review
Massive pooling of blood and waste products due to kidney and liver infections caused severe pain, vomiting, and hair loss for six months. After enduring a massive E-coli infection, I discovered lactoferrin online. I sent Jarrow's lactoferrin 250 mg capsules to my employee, instructing her to gradually increase to 1500 mg daily. Remarkably, by day four, the blood pooling vanished, kidney pain lessened, and her energy surged. With the E-coli gone, her health rapidly improved, leading to normal organ function and the disappearance of anaemia. Despite a brief relapse, she responded well to increasing lactoferrin again, showing how it significantly contributed to her recovery from these infections.

Herpes

SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 3 Reviews
8.7
9
Lactoferrin promotes antiviral efficacy
Lactoferrin-Functionalized Noble Metal Nanoparticles as New Antivirals for HSV-2 Infection.
Most Relevant Research
We investigated the potential of lactoferrin, a powerful natural compound, to inhibit herpes simplex viruses, specifically HSV-2. Our approach involved testing silver and gold nanoparticles modified with lactoferrin, known as LF-Ag/AuNPs, to see if they could serve as novel treatments or microbicides for genital herpes.

In our experiments with human skin and vaginal cells, we observed that LF-Ag/AuNPs were much more effective than lactoferrin on its own at preventing the virus from attaching to and entering cells. Notably, when we pretreated cells with LF-AgNPs, they were better protected from infection.

In tests with infected mice, those treated with LF-Ag/AuNPs had significantly lower virus levels in vaginal tissues and spinal cords compared to those treated with just lactoferrin. The immune response appeared to be enhanced too, as evidenced by increased counts of specific immune cells.

Overall, our findings suggest that LF-Ag/AuNPs not only fight the virus but may also boost immune function, highlighting their potential as effective new antiviral treatments targeting mucosal surfaces.
9.5
Blessing for pets
Most Useful Review
After five years of searching for a solution, this product is it! I mixed it with L-Lysine in my pet's wet food, and together they have stopped all the sneezing and coughing from feline herpes. My cats are getting along better now, and he is feeling well. It’s a blessing!

Acne

SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.4
USERS' SCORE
Good
Based on 28 Reviews
8.6
9
Lactoferrin reduces acne inflammation
Lactoferrin regulates sebogenesis and inflammation in SZ95 human sebocytes and mouse model of acne.
Most Relevant Research
We aimed to explore how lactoferrin affects acne by testing its anti-inflammatory and anti-lipid properties on human sebaceous gland cells and a mouse model. Using SZ95 cells, we treated them with varying concentrations of lactoferrin to observe its impact on cell viability, lipid content, and gene expression related to fat metabolism and inflammation.

Our tests showed that lactoferrin greatly reduced lipid accumulation in these cells while also lowering levels of inflammatory markers. In the acne mouse model, lactoferrin treatment also significantly reduced inflammation and lipid production. Additionally, it led to a decrease in the number of sebaceous gland cells and increased cell death, providing further evidence of its effectiveness.

We found that lactoferrin treatment resulted in lower protein levels associated with inflammation and lipid synthesis in the mice. Overall, our findings indicate that lactoferrin could play a beneficial role in managing acne by targeting both sebogenesis and inflammation.
9.5
Significant reduction
Most Useful Review
Possibly the solution for chronic adult acne. I'm in my late twenties and have been very prone to acne consistently since my teenage years. When I say I've tried everything, I truly mean it. Up until now, the only treatment that ever worked was prescription Accutane, which is harmful to the liver and has unpleasant side effects. After six months on Accutane, my skin stayed relatively clear for about six months, but soon after, serious acne returned. Since then, I have tested many supplements and creams, none of which helped. I eventually discovered a study indicating that acne was reduced in participants using lactoferrin enriched fermented milk. After beginning this product, my acne has significantly reduced within just two weeks.

Irritable Bowel Syndrome

SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 20 Reviews
8.6
8
Lactoferrin may treat stress-induced IBS
Vitamin D and lactoferrin attenuate stress-induced colitis in Wistar rats via enhancing AMPK expression with inhibiting mTOR-STAT3 signaling and modulating autophagy.
Most Relevant Research
We explored how lactoferrin might alleviate symptoms of irritable bowel syndrome (IBS) by examining its effects on stress-induced colitis in Wistar rats. In our study, we used a chronic wrap-restraint stress model to simulate the psychological stress that contributes to IBS.

The rats were divided into four groups: naïve rats, those subjected to stress, and two groups that received either vitamin D or lactoferrin. Our findings indicated that both lactoferrin and vitamin D improved various health markers compared to the stressed rats. Notably, lactoferrin treatment resulted in enhanced social behavior, increased levels of beneficial interleukin-10, and improved autophagy in the colon.

Furthermore, lactoferrin demonstrated a remarkable ability to decrease inflammatory markers and stress levels, suggesting it may modulate the body’s response to the inflammation linked with IBS. The results indicate that lactoferrin could be more effective than vitamin D for treating stress-induced colitis, making it a promising nutritional supplement for those struggling with IBS.
9.5
Symptoms alleviated
Most Useful Review
As a result, I developed gastrointestinal issues including irritable bowel syndrome. After taking probiotics and consulting doctors, I started this supplement, taking one capsule daily for a month alongside a probiotic. I was pleasantly surprised by the results: stomach anxiety and bloating disappeared. Now, I always keep this supplement on hand.

Back Pain

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Dramatic health improvements
Most Useful Review
After enduring continuous pain and severe symptoms due to Crohn's disease, I discovered lactoferrin. My colleague improved remarkably after starting it, with reduced kidney pain and normal organ functions. By day four, her back pain lessened significantly, and she felt her energy returning. A doctor was astounded to see her recovery without heavy antibiotics. It appears lactoferrin has been pivotal in her journey back to health.

Bone Pain

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Miraculous healing for mother
Most Useful Review
My elderly mother had a broken neck and was unaware for nearly a year, living in pain. I started giving her this product after learning it promotes bone regrowth. It has helped her tremendously with her healing process, alongside therapy and medical support. Now, both her spinal doctor and PCP recommend it to their patients.

Colitis

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Miracle for colitis
Most Useful Review
like a miracle for colitis

Headache

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Remarkable improvement
Most Useful Review
After enduring constant pain and severe symptoms from Crohn's disease, my employee found relief through lactoferrin. Following a horrific E-coli infection, I introduced her to Jarrow's lactoferrin 250 mg capsules, instructing her to gradually increase to 1500 mg daily. Within days, the pooling of blood diminished, her kidney pain lessened, and her headaches decreased notably. By the week's end, she was virtually pain-free. Her energy levels soared, and she began eating normally again. Despite a minor relapse after reducing her intake, increasing the dosage resolved it. The doctor was amazed at her transformation, noting no infections or organ issues, with her iron levels normalised thanks to lactoferrin's effectiveness against E-coli.

Kidney Infection

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Remarkable recovery
Most Useful Review
After months battling severe symptoms from a kidney and liver infection, I was desperate. My employee faced dire health issues due to E-coli during treatment. After discovering lactoferrin, I bought Jarrow’s capsules and instructed her to gradually increase her intake. Remarkably, she improved day by day, experiencing reduced pain and increased energy. Her doctor was astonished by her recovery, as tests later showed no infections or issues with her organs. We attribute her healing partly to the lactoferrin’s impact on her health.

Liver Disease

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Reduced liver inflammation
Most Useful Review
After six months of distress due to liver issues, my employee found relief with lactoferrin. Following an E-coli infection, she began a regimen that began with 500 mg of lactoferrin and increased to 1500 mg daily. Her health dramatically improved; pain lessened, jaundice cleared, and energy surged. Even under a doctor's supervision, she found that lactoferrin was more effective than antibiotics for managing liver inflammation.

Osteoporosis

SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 1 Review
8.6
8
Lactoferrin enhances osteoblast activity
Lactoferrin promotes the autophagy activity during osteoblast formation via BCL2-Beclin1 signaling.
Most Relevant Research
We explored how lactoferrin, a key component found in milk, plays a role in promoting osteoblast formation, which is crucial for preventing and treating osteoporosis. Our investigation looked at the effects of lactoferrin on the activity of primary osteoblasts—cells responsible for bone formation.

Our findings revealed that lactoferrin enhances the autophagy activity of these cells, a process that helps with cellular maintenance and function. We observed that lactoferrin impacts the BCL2 protein level in osteoblasts, which is connected to how autophagy is regulated. By increasing lactoferrin, we noted a decrease in BCL2 expression and its interaction with Beclin1, a protein needed for autophagy.

Ultimately, we learned that when BCL2 was overexpressed or Beclin1 was silenced, the beneficial effects of lactoferrin on autophagy and important osteogenic parameters were reversed. This suggests that lactoferrin may provide significant support for bone health by enhancing a specific pathway in osteoblast function, making it a promising candidate for osteoporosis treatment.
9.5
Bone strengthening
Most Useful Review
I bought this product for its bone health benefits. It aids osteoporosis by helping calcium absorption into the bones and prevents calcium loss. Hence, it naturally strengthens the bones when consuming calcium-rich foods.

Sore Throat

SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 1 Review
8.6
9
Lactoferrin shows potential in symptom relief
Supporting respiratory epithelia and lowering inflammation to effectively treat common cold symptoms: A randomized controlled trial.
Most Relevant Research
We explored how a throat spray containing lactoferrin, among other ingredients, impacts sore throat pain associated with the common cold. In a robust double-blind, randomized controlled trial, we gathered data from 157 participants who self-administered treatments over two days. This study aimed to determine whether combining lactoferrin with other agents could enhance symptom relief during cold episodes.

Our findings revealed that sore throat pain intensity significantly decreased among participants receiving treatments that included lactoferrin. The spray led to a reduction in pain intensity scores by approximately 68-75%, depending on the specific formulation used. While the study showed a promising decrease in sore throat and other cold symptoms like nasal discharge and cough, it's important to note that the effectiveness of lactoferrin was not isolated but incorporated into a combination therapy.

Overall, supporting respiratory health and reducing associated inflammation appears to be beneficial for treating common cold symptoms. However, lactoferrin's specific role, given it was administered alongside other active compounds, remains uncertain and requires further investigation to fully understand its individual effectiveness.
10
Instant sore throat relief
Most Useful Review
Took one pill, and my sore throat and cough disappeared. I can breathe easily. Great product!

Yeast Infection

SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Good
Based on 9 Reviews
8.5
9
Lactoferrin shows potential antifungal effects
Impact of Brief Exposure to Lysozyme and Lactoferrin on Pathogenic Attributes of Oral Candida.
Most Relevant Research
Our research investigated how brief exposure to lysozyme and lactoferrin affects pathogenic traits of two common Candia species, C. albicans and C. dubliniensis, which are often responsible for oral infections. We focused on factors like how well these fungi adhere to cells and surfaces in the mouth, their ability to form germ tubes, their cell surface hydrophobicity, and their production of harmful substances called haemolysins.

After treating these Candida isolates with lysozyme and lactoferrin for just one hour, we assessed their susceptibility and observed notable changes over a longer 48-hour incubation period. The results indicated that exposure to either lysozyme or lactoferrin could significantly reduce the adhesion and harmful properties of these yeast species in lab tests.

These findings suggest that even a brief contact with these natural compounds might provide a sustained antifungal effect, which could be crucial in managing conditions like oral candidosis. Given the growing resistance to standard antifungal treatments, we believe exploring the application of lysozyme and lactoferrin could lead to innovative therapies for yeast infections.
9.5
Effective for anemia
Most Useful Review
I was taking iron for my anemia and developed symptoms of a yeast infection. I discovered that yeast feeds on iron, hindering its absorption. Lactoferrin binds with iron, making it inaccessible to yeast and directing it to my cells. I'm grateful to iHerb for offering this product at a reasonable price.

Bacterial Infection

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Prevents infections effectively
Most Useful Review
Lactoferrin has been a well-maintained secret for its antibacterial, antiviral, and antifungal properties. My husband, a paraplegic, has been free of infections for over a year—something I can attribute directly to the consistency of this product, which has kept him safe from UTIs, pneumonia, and cellulitis.

Cancer

SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.6
USERS' SCORE
Good
Based on 1 Review
8.5
8
Lactoferrin peptide shows anticancer potential
Lactoferrin-Derived Peptide Chimera Induces Caspase-Independent Cell Death in Multiple Myeloma.
Most Relevant Research
We explored the potential of a synthetic peptide, derived from lactoferrin, to treat multiple myeloma, a type of cancer affecting plasma cells in the bone marrow. This peptide mimics the antibacterial properties of lactoferrin and appears to have anticancer effects as well.

In our experiments, the lactoferrin-derived chimera effectively inhibited the growth of multiple myeloma cell lines, including MM1S, MM1R, and RPMI8226. Notably, it induced both early and late stages of cell death in these cancer cells while sparing normal blood cells from damage.

Further analysis revealed that this peptide had a significant impact on the expression of genes tied to cell survival and apoptosis. We discovered that it triggers oxidative stress, leading to a generation of reactive oxygen species and mitochondrial dysfunction in cancer cells.

Importantly, while the peptide did not cause the typical caspase-dependent cell death we often observe in cancer treatments, it did promote a different form of apoptosis via the nuclear translocation of specific factors like apoptosis-inducing factor and endonuclease G.

Overall, this lactoferrin-derived peptide chimera shows promise in inducing a unique, caspase-independent form of cell death in multiple myeloma, suggesting it could be an effective new addition to cancer therapies.
8.8
Helps canine cancer
Most Useful Review
The product works well for me; I give it to my dog who has cancer, and it seems to be beneficial. The service has also been commendable.

Cough

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
10
Cough disappeared quickly
Most Useful Review
Excellent product. After taking just one pill, my sore throat and cough disappeared, allowing me to breathe easily. I highly recommend it!

Flu

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.3
No flu symptoms
Most Useful Review
I was unwell in December and decided to try this supplement. I took it for about a month and since then, I haven't had any colds or flu. I feel much better, and this supplement seems to be working for me.

Ulcer

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8
Miracle supplement
Most Useful Review
It's somewhat of a miracle supplement if claims hold true. Lactoferrin is said to be an immunomodulator that aids with ulcers and promotes healthy gut bacteria. The only medically verified benefit is for some Hepatitis C patients. I have no doubt about its efficacy and plan to try it alongside a GAPS diet to enhance gut flora.

Cold

SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 5 Reviews
8.4
9
Evaluating lactoferrin for colds
Supporting respiratory epithelia and lowering inflammation to effectively treat common cold symptoms: A randomized controlled trial.
Most Relevant Research
We conducted a study to investigate the potential of a throat spray containing lactoferrin, along with other ingredients, to alleviate cold symptoms. This double-blind, placebo-controlled trial involved 157 participants who self-administered treatments and reported their experiences over 36 hours. We aimed to see if this combination could improve upon the effectiveness of aspirin, which has shown only modest benefits in relieving cold symptoms.

While our findings indicated that the treatment significantly reduced sore throat pain and other cold symptoms, it is important to note that the exact contribution of lactoferrin remains unclear. This is because the throat spray included multiple active components, including lysozyme and aloe, making it difficult to isolate lactoferrin's specific effects. Overall, we observed a marked reduction in symptom severity, with improvements noted across the board for the treatments administered.

Although this study highlighted a promising approach to supporting respiratory health and managing cold symptoms, we cannot definitively say that lactoferrin alone was responsible for these outcomes. Thus, while the results are encouraging, additional research is needed to clarify the distinct role of lactoferrin in treating colds.
9.5
Shortens cold sore
Most Useful Review
Cold sore be gone! I read that this could help shorten the duration of cold sores by inhibiting some common viruses, like herpes simplex 1. A few days ago, I felt tingling around my lip; I took a couple of pills and by the next morning, a few red bumps appeared and that was it—I never had a full-blown cold sore. For my intended purpose, this product did its job.

Common Cold

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 44 Reviews
8
10
No illness for months
Most Useful Review
Lactoferrin is amazing! After taking it daily, I haven’t caught a cold in four months, despite everyone at the office being sick. It’s truly made a difference.

Candidiasis

SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6.7
USERS' SCORE
Good
Based on 1 Review
8
8
Lactoferrin combats oral candidiasis
Lactoferrin as a potential therapeutic for the treatment of Candida-associated denture stomatitis.
Most Relevant Research
We investigated how lactoferrin, a multifunctional protein found in saliva, impacts the treatment of candidiasis, particularly in the context of denture stomatitis caused by Candida. This condition is often challenging to manage due to lingering factors and the potential for repeated occurrences.

Our findings highlight that lactoferrin is believed to be a first line of defense against microbial threats on mucosal surfaces. We discovered that lactoferrin and its derivatives have the potential to tackle a wide range of Candida species effectively.

Given the rise in drug resistance among fungi, the search for new treatments is crucial. Lactoferrin presents an interesting option, either on its own or alongside established medications, for improving outcomes in oral candidiasis treatment. This review sheds light on the current understanding and efficacy of lactoferrin's antifungal properties in dealing with oral candidiasis.
3.5
No improvement
Most Useful Review
I tried this product for my candidiasis (systemic yeast infection) but received no results and will discontinue use.

Allergies

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
0
Buyer beware
Most Useful Review
I would NOT recommend this for cats. I bought this based on a site recommendation for allergies and feline herpes, but it caused my cats spastic diarrhea. After researching magnesium stearate, I found it can cause side effects like loss of appetite and fatigue, which my cats experienced.

Hives

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
0
Caused hives
Most Useful Review
This Jarrow Lactoferrin caused hives after just one dose. I continued initially, but once I realised the link, I stopped taking it, and the hives cleared up. I'm re-evaluating the quality of Jarrow products after this.

Diarrhea

SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7
USERS' SCORE
Medium or Average
Based on 17 Reviews
6.3
7
Lactoferrin reduces diarrhea in children
Efficacy of lactoferrin supplementation in pediatric infections: A systematic review and meta-analysis.
Most Relevant Research
We conducted a comprehensive review and meta-analysis to understand how lactoferrin (LF) supplementation affects diarrhea in children. This involved examining a number of randomized controlled trials involving participants under 18 years old.

From our analysis, which sifted through an impressive 1,594 citations, we identified 25 studies that met our criteria. Notably, out of these, 14 studies focused specifically on diarrhea. Our findings indicated that LF supplementation was linked to fewer children experiencing diarrhea compared to those receiving a placebo.

Specifically, the odds of having diarrhea were reduced (with an odds ratio of 0.56) when children were given LF compared to those who weren't. This suggests that lactoferrin could be helpful in reducing the incidence of diarrhea in the pediatric population. However, it's important to note that while the results are promising, further refinement in trial design is necessary to fully understand LF's potential as a public health tool.
9.5
Odour reduction
Most Useful Review
This is a supplement I frequently buy. Although the price has increased, I continue taking it for my intestinal health. Unless I consume a lot of fatty foods or desserts, I no longer notice any stool odour. I believe this has also eliminated body odour, particularly noticeable in summer. I even give a small amount to my dog, and he too has benefited from reduced stool odour. However, caution is advised when administering it to pets.
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