Supplement Facts
Serving Size: 1 Softgel
Serving Per Container: 120
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
The product is found useful for the following medical conditions
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.7
10
Life-changing effects
Most Useful Review
21 people found this helpful
I had so many continuous muscle cramps throughout my body. After trying numerous supplements, I stumbled upon a doctor on TV who mentioned that a shortage of Co Q10 in the heart can lead to these cramps. I began taking two Co Q10 capsules daily—one in the morning and one in the evening—and after two weeks, I could walk, sleep, and stretch without cramps. My hands and fingers, which were also cramping, are now fine. For almost two years, I've relied on this particular product and find it to be the best on the market; it's well absorbed and I wouldn't consider using anything else.
Updated: Mar 2026
Sleep Apnea details
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
4.8
USERS' SCORE
Good
Based on 3 Reviews
8.6
0
CoQ10 ineffective for mitochondrial sleep apnea
We examined a rare case of mitochondrial encephalomyopathy featuring multiple complications including sleep apnea, cerebellar ataxia, and peripheral neuropathy—a combination never before documented in medical literature. The patient received six months of coenzyme Q10 therapy to address the underlying mitochondrial dysfunction.
Unfortunately, the treatment proved ineffective. Neither the cerebellar ataxia nor the abnormal pyruvate metabolism improved with CoQ10 supplementation. While sleep apnea was identified as a significant prognostic factor in this mitochondrial disorder, the supplement failed to alleviate this serious breathing complication or other associated symptoms.
Unfortunately, the treatment proved ineffective. Neither the cerebellar ataxia nor the abnormal pyruvate metabolism improved with CoQ10 supplementation. While sleep apnea was identified as a significant prognostic factor in this mitochondrial disorder, the supplement failed to alleviate this serious breathing complication or other associated symptoms.
9
Improved sleep quality
Most Useful Review
3 people found this helpful
Useful, I have AIT. Thanks to iHerb and the reviews, I decided to order Q10 100mg. In the first week, I felt a bit strange, with a buzzing in my head. However, I then felt rejuvenated; my sleep returned to normal, and I wake joyfully in the morning (anyone with AIT will understand). I have ample energy now, no longer feel drowsy during the day, and, crucially, my blood pressure normalised. On the advice of Omega, I also take MK 7 and D. I genuinely appreciate the improvements in my quality of life.
Updated: Apr 2026
Allergies details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.5
8
We investigated how coenzyme Q10 (Co-Q10) affects allergies, particularly allergic rhinitis and asthma. In our study, we used animal models to mimic these conditions and treated them with Co-Q10, either alone or alongside other compounds like Omega-3 and magnesium sulfate.
We collected and analyzed samples from the lungs, measuring various inflammatory markers such as cytokines and IgE levels, which play critical roles in allergic reactions. The results indicated that Co-Q10 helps promote the activity of a protective protein called Nrf2, which is crucial in defending against allergic responses and inflammation.
By increasing Nrf2 levels, Co-Q10 showed potential in reducing the symptoms associated with allergic conditions, helping to control allergic mediators and inflammatory factors. Overall, we found that Co-Q10 treatment could enhance the body’s resilience to allergens, potentially offering a powerful tool against allergic rhinitis and asthma.
We collected and analyzed samples from the lungs, measuring various inflammatory markers such as cytokines and IgE levels, which play critical roles in allergic reactions. The results indicated that Co-Q10 helps promote the activity of a protective protein called Nrf2, which is crucial in defending against allergic responses and inflammation.
By increasing Nrf2 levels, Co-Q10 showed potential in reducing the symptoms associated with allergic conditions, helping to control allergic mediators and inflammatory factors. Overall, we found that Co-Q10 treatment could enhance the body’s resilience to allergens, potentially offering a powerful tool against allergic rhinitis and asthma.
9
Reduction in sneezing
Most Useful Review
I believe this form of CoQ10 is excellent for immunity, and I have noticed some positive results. However, its most significant benefit for me has been in alleviating my allergies. I now sneeze considerably less than I did before using this product. While it is not inexpensive, I find it to be very effective. The Thorne brand consistently delivers high-quality products, and I appreciate their commitment to using the best ingredients, which holds true for this form of CoQ10 as well.
Updated: Apr 2025
Chest Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7
USERS' SCORE
Good
Based on 3 Reviews
8.5
9
CoQ10 reduces post-heart attack complications significantly
A randomized, double-blind placebo-controlled trial compared 120 mg daily of coenzyme Q10 to placebo over 28 days in 144 heart attack patients. Those receiving CoQ10 experienced significantly fewer cases of chest pain, heart rhythm problems, and poor heart function compared to the placebo group. Importantly, major cardiac events—including heart deaths and repeat heart attacks—dropped to 15% with CoQ10 versus 31% with placebo.
We observed that CoQ10 treatment enhanced the body's natural antioxidant defenses and reduced markers of cellular damage. These results suggest CoQ10 may offer rapid protection when given shortly after a heart attack, though larger studies with longer follow-up are needed to fully confirm these encouraging findings.
We observed that CoQ10 treatment enhanced the body's natural antioxidant defenses and reduced markers of cellular damage. These results suggest CoQ10 may offer rapid protection when given shortly after a heart attack, though larger studies with longer follow-up are needed to fully confirm these encouraging findings.
9
Relieved symptoms
Most Useful Review
I recently experienced chest tightness and difficulty breathing without any clear diagnosis. Suspecting a cardiovascular issue, I opted for CoQ10. After finishing my second bottle, I find that my symptoms are significantly relieved. I’ll continue taking this supplement and recommend it to others.
Updated: Apr 2026
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.3
9.5
We explored the potential benefits of idebenone, a synthetic analog of coenzyme Q10, in treating autoimmune disorders, specifically lupus, in mouse models. By administering idebenone to mice with lupus for eight weeks, we aimed to investigate its impact on disease activity and organ damage.
Our findings showed that idebenone led to a significant reduction in disease severity. Mice that received idebenone exhibited lower mortality rates and improvements in kidney function, indicated by reduced glomerular inflammation and lower levels of certain inflammatory markers. The treatment also minimized the production of proinflammatory cytokines and enhanced mitochondrial metabolism.
Besides benefiting the kidneys, idebenone diminished markers of inflammation throughout the body, which is crucial since lupus often results in systemic damage. Importantly, we noticed that idebenone improved overall metabolism in these mice without causing obvious side effects.
This research supports the idea that modulating mitochondrial function can be a promising therapeutic strategy for managing lupus, opening the door for future studies on its effectiveness in humans.
Our findings showed that idebenone led to a significant reduction in disease severity. Mice that received idebenone exhibited lower mortality rates and improvements in kidney function, indicated by reduced glomerular inflammation and lower levels of certain inflammatory markers. The treatment also minimized the production of proinflammatory cytokines and enhanced mitochondrial metabolism.
Besides benefiting the kidneys, idebenone diminished markers of inflammation throughout the body, which is crucial since lupus often results in systemic damage. Importantly, we noticed that idebenone improved overall metabolism in these mice without causing obvious side effects.
This research supports the idea that modulating mitochondrial function can be a promising therapeutic strategy for managing lupus, opening the door for future studies on its effectiveness in humans.
7.5
Cardiovascular relief
Most Useful Review
2 people found this helpful
I love this brand; I have taken various formulations with ubiquinone, and they have always worked for me. I feel relief in my cardiovascular system and experience a boost of energy. My husband and I tried less expensive brands without any observable effects. We returned to this brand, which may cost more, but we noticed the effects immediately upon taking it.
Updated: Mar 2026
Cardiovascular Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
USERS' SCORE
Good
Based on 7 Reviews
8.3
9
We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.
In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.
In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
9
Highly absorbable formula
Most Useful Review
Jarrow Formulas Q-Absorb CoQ10 is now my preferred choice for heart health support. This vital compound promotes cardiovascular health and energy production. The Q-Absorb technology enhances absorption, ensuring I benefit fully from CoQ10. With 100 mg in each softgel, it conveniently supports heart health. I trust Jarrow Formulas for their quality. This product is free from unnecessary additives, making it a hassle-free way to enhance cardiovascular health.
Updated: Apr 2025
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.3
8
We embarked on a study to investigate the impact of ubiquinol-10—an active form of coenzyme Q10—on patients suffering from chronic fatigue syndrome (CFS). Our research comprised two parts: an open-label study involving 20 patients and a randomized, double-blind, placebo-controlled trial with 43 participants.
In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.
Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.
Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.
In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.
Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.
Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.
7.5
Restores energy effectively
Most Useful Review
1 people found this helpful
Difficult to swallow, but effective in restoring energy. These capsules provide the most easily absorbed form of Co-Q10, ubiquinol. The dosage is perfect: 100mg or one capsule per day in the morning. I take them following a burnout that led to adrenal fatigue and general exhaustion. I take Co-Q10 to repair my damaged mitochondria, which produce 90% of the energy we need to function. I slowly feel my energy returning, so I think it's a good product. However, I am disappointed by the enormous size of the capsules and their smell, which is reminiscent of caramel and fish. I also wish the product didn't contain soya. I hope the manufacturer improves these aspects!
Updated: Mar 2026
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.2
USERS' SCORE
Good
Based on 5 Reviews
8.3
9
We delved into the effects of coenzyme Q10 (CoQ10) supplementation on cholesterol levels in adults to determine how it can influence lipid profiles. Through a thorough meta-analysis of fifty randomized controlled trials involving nearly 2800 participants, we explored its potential benefits for reducing cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.
Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.
9
Normal cholesterol levels
Most Useful Review
1 people found this helpful
I have taken these for a few years as I have high cholesterol. They have helped reduce my cholesterol to normal levels, which means I no longer require any medication.
Updated: Apr 2025
Hypertension details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 2 Reviews
8.3
7
Citicoline and CoQ10 protection study
We investigated how a combination of citicoline and coenzyme Q10 (CoQ10) might impact retinal cell health in a mouse model of ocular hypertension (OHT). Using four groups of mice, including those receiving the combination treatment and a control group, we aimed to understand if these substances could protect against the loss of retinal ganglion cells, which is a major concern in glaucoma.
The treatment was started 15 days prior to inducing ocular hypertension with a laser and continued until we examined the mice about a week later. Our findings were promising: the combination of citicoline and CoQ10 led to a temporary reduction in eye pressure shortly after treatment. Furthermore, it significantly prevented the death of specific retinal cells that are vital for vision.
While we were encouraged by these results, especially regarding cell protection, it's important to note that there were no significant impacts on neurons in the visual pathway areas we studied, like the dLGN. Overall, our research suggests that this combination might offer neuroprotective benefits in specific aspects of ocular hypertension, paving the way for further exploration into treatments that go beyond only lowering eye pressure.
The treatment was started 15 days prior to inducing ocular hypertension with a laser and continued until we examined the mice about a week later. Our findings were promising: the combination of citicoline and CoQ10 led to a temporary reduction in eye pressure shortly after treatment. Furthermore, it significantly prevented the death of specific retinal cells that are vital for vision.
While we were encouraged by these results, especially regarding cell protection, it's important to note that there were no significant impacts on neurons in the visual pathway areas we studied, like the dLGN. Overall, our research suggests that this combination might offer neuroprotective benefits in specific aspects of ocular hypertension, paving the way for further exploration into treatments that go beyond only lowering eye pressure.
7.5
Absorption enhancement
Most Useful Review
35 people found this helpful
Excellent product! Although this is not Ubiquinol, it absorbs slightly better and costs less. It is now recommended in a new nutrition book titled "It's Not the Cans: The Best Nutrient Balance for a Stronger and Healthier You." I believe this product is suitable for all ages. For those unfamiliar with CoQ10, it has been suggested that individuals over 40 struggle to absorb regular CoQ10 effectively, hence the recommendation for the more costly Ubiquinol. This was accurate 6+ years ago, but no longer holds true! Recent studies suggest this product absorbs better than Ubiquinol and is more affordable. Science evolves, and competition fosters advancements in health supplements.
Updated: Apr 2025
Brain Tumor details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.6
USERS' SCORE
Good
Based on 3 Reviews
8.2
9
CoQ10 reduces glioblastoma growth
The study focused on understanding how coenzyme Q10 (CoQ) could help manage glioblastoma, a particularly challenging type of brain tumor. We utilized xenograft models with U251 cells implanted in mice to observe tumor growth, inflammation, and vascular changes, alongside assessing the effects of CoQ on various related behaviors, including cell migration and invasion.
We found that CoQ treatment significantly reduced tumor volume in both xenograft and orthotopic models. Interestingly, while it did not directly hinder tumor cell proliferation, it was effective in creating a less hypoxic and vascularized environment. This indicates that CoQ can influence the tumor’s growth dynamics by targeting the underlying conditions that support tumor survival and expansion.
Additionally, CoQ treatment led to a noticeable downregulation of proteins involved in inflammation and angiogenesis, like HIF-1α and NF-kB. This change in molecular activity caused an entire reshaping of the tumor's protein landscape, ultimately impacting how the tumor interacts with its environment. Notably, we observed a restriction in tumor cell migration and invasion, attributed to changes in the cell's structural components.
Overall, our findings suggest that incorporating CoQ into current treatment protocols could provide a holistic approach to combat glioblastoma by simultaneously addressing multiple pathways that facilitate tumor growth and infiltration.
We found that CoQ treatment significantly reduced tumor volume in both xenograft and orthotopic models. Interestingly, while it did not directly hinder tumor cell proliferation, it was effective in creating a less hypoxic and vascularized environment. This indicates that CoQ can influence the tumor’s growth dynamics by targeting the underlying conditions that support tumor survival and expansion.
Additionally, CoQ treatment led to a noticeable downregulation of proteins involved in inflammation and angiogenesis, like HIF-1α and NF-kB. This change in molecular activity caused an entire reshaping of the tumor's protein landscape, ultimately impacting how the tumor interacts with its environment. Notably, we observed a restriction in tumor cell migration and invasion, attributed to changes in the cell's structural components.
Overall, our findings suggest that incorporating CoQ into current treatment protocols could provide a holistic approach to combat glioblastoma by simultaneously addressing multiple pathways that facilitate tumor growth and infiltration.
7.5
Boosts energy levels
Most Useful Review
I chose this form of CoQ10 because of its quality and beneficial additives that enhance absorbance. I've noticed significant improvements in my energy levels and brain function. While I haven't observed benefits for my skin, topical CoQ10 is renowned for such effects. This fat-soluble antioxidant is crucial for my health.
Updated: Mar 2026
Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.8
USERS' SCORE
Good
Based on 2 Reviews
8.2
9
CoQ10 mitigates chemobrain effects
We explored the potential benefits of Coenzyme Q10 (CoQ10) on cancer patients dealing with a condition commonly referred to as "Chemobrain," which is associated with treatment using the chemotherapy drug cyclophosphamide (CYP). In our study, male rats were given a daily dose of CoQ10 for ten days, while they also received a single dose of CYP to model the effects of chemotherapy on cognition and motor skills.
The findings were promising. CoQ10 not only helped counteract cognitive and motor dysfunctions triggered by CYP but also showed significant neuroprotective effects. Behavioral tests demonstrated improvements, and histopathological analysis confirmed that CoQ10 reduced brain damage linked to oxidative stress caused by CYP. This micronutrient effectively restored levels of the antioxidant enzyme catalase and lowered harmful substances like malondialdehyde.
Furthermore, CoQ10 appeared to inhibit neuronal apoptosis, or cell death, by balancing expressions of key proteins involved in the process. It supported neurogenesis in the hippocampus by increasing important growth factors. Most notably, CoQ10 activated the Wnt/β-catenin signaling pathway, which is crucial for brain health and development.
Overall, our study highlights how CoQ10 may offer a multi-faceted approach to mitigating the adverse effects of chemotherapy on cognitive function, bolstering both brain protection and regeneration.
The findings were promising. CoQ10 not only helped counteract cognitive and motor dysfunctions triggered by CYP but also showed significant neuroprotective effects. Behavioral tests demonstrated improvements, and histopathological analysis confirmed that CoQ10 reduced brain damage linked to oxidative stress caused by CYP. This micronutrient effectively restored levels of the antioxidant enzyme catalase and lowered harmful substances like malondialdehyde.
Furthermore, CoQ10 appeared to inhibit neuronal apoptosis, or cell death, by balancing expressions of key proteins involved in the process. It supported neurogenesis in the hippocampus by increasing important growth factors. Most notably, CoQ10 activated the Wnt/β-catenin signaling pathway, which is crucial for brain health and development.
Overall, our study highlights how CoQ10 may offer a multi-faceted approach to mitigating the adverse effects of chemotherapy on cognitive function, bolstering both brain protection and regeneration.
7.5
Cancer treatment impact
Most Useful Review
Coenzyme Q10 boasts high absorption and antioxidative properties, which have shown considerable inhibitory effects on atherosclerosis formation. Its anti-tumour properties yield significant results in advanced metastatic cancer treatment and cardiovascular health, aiding conditions like coronary heart disease and alleviating angina pectoris. Additionally, Q10 can mitigate skin aging by combating wrinkles when adequately present in the cells, enhancing energy metabolism and eliminating free radicals.
Updated: Apr 2025
Liver Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.2
We conducted a study to explore the effects of high-dose coenzyme Q10 supplementation on patients suffering from liver disease related to metabolic dysfunction, known as Metabolic-dysfunction Associated Steatotic Liver Disease (MASLD). In a well-structured double-blind, placebo-controlled trial with sixty participants, half received 240 mg of coenzyme Q10 daily, while the other half received a placebo for six months.
Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.
Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.
Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.
Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.
7.5
Effective for health
Most Useful Review
Coenzyme Q10 has good ingredients, and I believe it will be effective for cardiovascular and cerebrovascular diseases. I find it very effective to take one pill with a meal, and it’s convenient that it is delivered. The packaging is impressive, the quality is high, and the portion provided is sufficient. I am optimistic about its benefits.
Updated: Apr 2025
Heart Attack details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 8 Reviews
8.1
9
We investigated how coenzyme Q10 might help with heart function after a heart attack, particularly focusing on its role in heart remodeling. In a well-structured study involving 55 patients with left ventricular dysfunction following an acute myocardial infarction, we compared the effects of coenzyme Q10 to a placebo over a 24-week period.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
9
Avoided disability
Most Useful Review
10 people found this helpful
After my husband had a heart attack and stenting, he began taking this drug. The doctor referred him for disability assessment, but after starting the medication, we noticed significant improvements. The doctor indicated that he wouldn't qualify for disability due to these improvements, which we are thrilled about! We are very grateful to the manufacturer for this outcome.
Updated: Mar 2026
Heart Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Good
Based on 24 Reviews
8
9
We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
9
Increased heart support
Most Useful Review
112 people found this helpful
Great drug. The problem with coQ10 supplements is that ubiquinone is poorly absorbed (1-3%). However, animal studies show that even this amount significantly increases coQ10 levels in the blood. Despite this, manufacturers are attempting to increase bioavailability. The Q-absorb system uses lipid absorption mechanisms. When taking Q-absorb, an increase of 150% in plasma coQ10 was recorded in 2 weeks, and over 200% in a month. I convinced my father (85) to take coQ10 after a heart attack in 2015, and my mother (85, severe heart failure) joined later. They have been taking it regularly since then, and there have been no complaints about their hearts despite previous urgent surgery recommendations.
Updated: Apr 2025
Blood Clot details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.7
9
We explored how coenzyme Q10 (CoQ10), a natural compound found in various foods, impacts blood clotting functions. Through a well-structured study, we utilized a randomized, double-blind, placebo-controlled trial with dyslipidemic patients, alongside in vitro tests on human platelets.
Our findings demonstrated that CoQ10 effectively reduces platelet aggregation, granule secretion, platelet spreading, and clot retraction. This means that CoQ10 can help prevent excessive blood clot formation, which is crucial for cardiovascular health.
We observed that CoQ10 works mainly by enhancing a signaling pathway involving cyclic AMP (cAMP) which ultimately diminishes the signaling of integrin αIIbβ3, a key player in platelet function. In addition, the treatment showed promising results in reducing thrombus growth in an animal model, suggesting significant in vivo benefits as well.
This study highlights the potential of CoQ10 supplementation as a protective measure for individuals at risk of cardiovascular diseases by regulating platelet-related processes involved in clotting.
Our findings demonstrated that CoQ10 effectively reduces platelet aggregation, granule secretion, platelet spreading, and clot retraction. This means that CoQ10 can help prevent excessive blood clot formation, which is crucial for cardiovascular health.
We observed that CoQ10 works mainly by enhancing a signaling pathway involving cyclic AMP (cAMP) which ultimately diminishes the signaling of integrin αIIbβ3, a key player in platelet function. In addition, the treatment showed promising results in reducing thrombus growth in an animal model, suggesting significant in vivo benefits as well.
This study highlights the potential of CoQ10 supplementation as a protective measure for individuals at risk of cardiovascular diseases by regulating platelet-related processes involved in clotting.
9
Controls arrhythmia effectively
Most Useful Review
1 people found this helpful
I’ve been using it for an extended period to manage my blood pressure and arrhythmia. It is effective and does its job well!
Updated: Mar 2026
Migraine details
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.5
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.7
9
We conducted a study to see how coenzyme Q10 (CoQ10) supplementation impacts migraine symptoms and inflammation. This randomized double-blind trial involved 45 non-menopausal women with episodic migraines.
Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.
Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.
Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.
7.5
Reduces migraines
Most Useful Review
I trust the Jarrow brand for its reliability. CoQ10 appears beneficial for cardiovascular health, particularly in older individuals, and it has also reduced my migraines. Initially, it made me a bit sleepy, so I take it at night now.
Updated: Mar 2026
Data last updated:
