Jarrow Formulas QH-absorb 100mg

We aimed to understand how ubiquinol, also known as coenzyme Q10 (CoQ-10), can impact those suffering from heart failure (HF). To do this, we conducted a thorough review of existing studies, searching databases like MEDLINE and the Cochrane Library for relevant literature.

Throughout our evaluation, we focused on key outcomes: whether CoQ-10 could reduce HF-related mortality, improve patients' exercise capacity, and affect the left ventricular ejection fraction (LVEF). Our analysis included findings from 16 different studies that provided intriguing insights.

Notably, we observed that CoQ-10 was effective in reducing HF-related mortality by an impressive 40%. Additionally, patients taking CoQ-10 reported enhanced exercise capacity, which is crucial for improving their quality of life. However, when it came to the left ventricular ejection fraction, the results were less clear; we found no significant difference, though we acknowledge that further research is needed to fully explore its potential effects in this area.

In summary, CoQ-10 shows promise in supporting heart failure patients by reducing mortality and boosting exercise capacity, but its role related to LVEF still warrants additional exploration.

9.5

Remarkable recovery achieved

Most Useful Review

How do I adore PQQ? Let me count the ways! It is essential for cardiac patients. My husband suffers from severe congestive heart failure, and I was once told he would not survive much longer. However, we pursued the Sinatra Solution, focusing on Metabolic Cardiology. Co-enzyme Q10 was vital, and we later discovered PQQ. Within days of using QH+PQQ, he became somewhat functional again. This transformation allowed him to attend a baseball game, something we never thought would happen again. The importance of PQQ for cardiac health cannot be overstated; it's crucial for mitochondrial health and energy production.

Chest Pain

Ubiquinol is crucial for heart health, especially for those who don't tolerate pharmaceuticals well. After experiencing a heart attack, I found that Ubiquinol provided the needed support, effectively halting the chest pain I felt when unable to see a doctor. It has significantly improved my energy levels and blood pressure readings without side effects. Increasing my magnesium intake alongside has also contributed to my relief.

Heart Attack

SCIENTIFIC SCORE

Likely Very Effective

Based on 2 Researches

USERS' SCORE

Excellent

Based on 32 Reviews

Mitochondrial cocktail enhances heart protection

Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat.

Most Relevant Research

We designed a study with male Wistar rats, aged 22-24 months and induced with type-2 diabetes, to investigate how a combination of three mitochondrial agents—melatonin, nicotinamide mononucleotide (NMN), and ubiquinol—could provide protection against myocardial ischemia/reperfusion (I/R) injury, especially in the context of aging and diabetes.

The rats were split into groups receiving different treatments, including some that received the cocktail of supplements just during the reperfusion phase after inducing I/R injury. Over 28 days leading up to the tests, rats received NMN, while melatonin and ubiquinol were administered as the heart was being revived after ischemia.

The results indicated that the combination therapy notably enhanced heart protection and improved mitochondrial function and biogenesis in these aged diabetic rats. While ubiquinol was an important part of this cocktail, it is essential to view its role as one among several synergistic agents. This points to exciting possibilities for improved heart health strategies, particularly for older individuals with diabetes.

9.5

Heart and brain health

Most Useful Review

I’ve been taking Co-Enzyme Q10 for over 25 years. This supplement is effective, though it won't cure all heart issues, especially with age. After experiencing chest pain that was ultimately diagnosed as not a heart attack, my cardiologist confirmed my arteries were clear. I credit my continued vitamin regimen with supporting my heart and brain health.

Arthritis

CoQ10 shows promise for arthritis

Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial.

Most Relevant Research

We explored the effects of Coenzyme Q10 (CoQ10) supplementation on individuals suffering from rheumatoid arthritis, a condition characterized by heightened levels of inflammation. Conducted as a double-blind, randomized controlled trial, our study included 44 participants, divided into two groups: one received 100 mg of CoQ10 daily, while the other took a placebo over a two-month period.

By measuring important markers like malondialdehyde (MDA), total antioxidant capacity (TAC), interleukin (IL)-6, and tumor necrosis factor alpha (TNF-α) before and after the intervention, we aimed to assess how CoQ10 might influence oxidative stress and inflammation.

The results indicated a significant decrease in serum MDA levels among those who took CoQ10, suggesting improved oxidative stress levels. Additionally, we noted a suppression of TNF-α, a key inflammatory cytokine. However, we found no significant changes in TAC or IL-6 levels between the two groups, which indicates that while CoQ10 seems to offer some benefits in reducing certain inflammatory markers, its overall effect on oxidative stress and other pro-inflammatory cytokines may be more limited than anticipated.

Thus, this study highlights the potential of CoQ10 as a supplementary treatment for managing inflammation in rheumatoid arthritis, although further research is needed to fully understand its role compared to other forms such as ubiquinol.

9.5

Energy restored

Most Useful Review

The best supplement I've ever used! This ubiquinol has been miraculous for both my 83-year-old mother and me, as I’m 57 with rheumatoid arthritis. Our energy levels surged within two weeks, allowing us to do activities we hadn’t for years!

Hypertension

Ubiquinol shows partial benefits

Sex-Dependent Protective Effect of Combined Application of Solubilized Ubiquinol and Selenium on Monocrotaline-Induced Pulmonary Hypertension in Wistar Rats.

Most Relevant Research

We explored the impact of ubiquinol on pulmonary hypertension using a model that mimics this serious condition. In our study, rats were injected with monocrotaline, a substance known to induce pulmonary hypertension. Over the course of the experiment, we provided various groups of these rats with different treatments, including solubilized ubiquinol and selenium, to see how these substances could protect against the effects of the disease.

The results were quite enlightening. We observed that ubiquinol administered intravenously had a protective effect, especially in male rats. This treatment reduced the right ventricle hypertrophy and lung mass commonly associated with elevated blood pressure in the lungs. Interestingly, when we combined ubiquinol with selenium, we found a less severe increase in right ventricle systolic pressure in males but not in females, indicating a sex-dependent effect that suggests females may not experience the same benefits from this combination treatment.

However, it's worth noting that the relative mass of the right ventricle did not show significant differences across all treatment groups. This suggests that while ubiquinol can be beneficial, particularly in males, the overall benefits may be limited and not as pronounced in females. Magnetic resonance imaging further revealed impaired lung perfusion in most rats tested, with signs of pulmonary fibrosis only present in the group receiving ubiquinol.

Overall, while ubiquinol shows potential in addressing pulmonary hypertension, its effectiveness might vary based on sex and should be approached with cautious optimism.

9.5

Improved blood pressure

Most Useful Review

Having been on four blood pressure medications for resistant hypertension for over 15 years, I developed tinnitus, possibly due to my meds. While researching treatments, I discovered the benefits of CoQ10 levels. After starting Ubiquinol, my blood pressure improved significantly, allowing me to stop my calcium channel blocker. Swimming workouts also became much easier. I highly recommend consulting a healthcare professional before starting CoQ10/Ubiquinol.

Menopause

Lowered blood pressure

Most Useful Review

Lowered my BP!! Try it! I had low blood pressure all of my life until menopause, which, as every woman knows, wreaks havoc on your body. Even with medication, my BP would be high (140/94) when I visited the doctor's office. Since I bought this product, my numbers are amazing! I take my BP at home, and my readings are as good as they were when I was in my 20s and 30s. My palpitations have also ceased. I take Metoprolol, but I still had palpitations while lying down at night; they are now gone! I still take all my medications, but this product seems to have made all the difference. I hope to wean off the other stuff safely. Love it!

Rheumatoid Arthritis

CoQ10 reduces inflammation and oxidative stress

Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial.

Most Relevant Research

We engaged in a careful exploration of how Coenzyme Q10, commonly known as CoQ10, affects patients with rheumatoid arthritis. By conducting a double-blind, randomized controlled trial including 44 participants, we divided them into two groups: one received daily capsules of 100 mg CoQ10 while the other was given a placebo for two months.

Our main focus was on monitoring changes in proinflammatory cytokines, specifically TNF-α and IL-6, and assessing levels of oxidative stress markers like malondialdehyde (MDA) and total antioxidant capacity (TAC). The results were promising; we observed a significant drop in MDA levels among those taking CoQ10, which indicates a reduction in oxidative stress. Additionally, there was a noteworthy decrease in the levels of TNF-α in the CoQ10 group compared to those taking the placebo.

However, it is important to highlight that while this study demonstrates some beneficial effects of CoQ10 on inflammatory markers, we did not find significant differences in TAC and IL-6 between the groups. Overall, our findings suggest that CoQ10 supplementation may be a valuable addition to managing oxidative stress and inflammatory responses in rheumatoid arthritis patients.

9.5

High energy

Most Useful Review

The best supplement I have ever used! This ubiquinol has worked miracles for me and my mother. Within two weeks, our energy levels soared, enabling us to engage in activities we hadn't done in years. I’ll never be without this supplement!

Back Pain

An excellent remedy that boosts strength and helps burn stomach fat. After taking two capsules (200 mg), I feel energetic and want to run outside. After a month, I noticed significant diet effects. This product is essential daily, especially for nerves; it calms quickly and eases tension in my heart. If finances are tight, I would select ubiquinol as my top choice.

Blood Clot

SCIENTIFIC SCORE

Likely Very Effective

Ubiquinol's impact on blood clotting

Ubiquinol Effects on Antiphospholipid Syndrome Prothrombotic Profile: A Randomized, Placebo-Controlled Trial.

Most Relevant Research

With a focus on antiphospholipid syndrome (APS), we set out to understand how ubiquinol, a reduced form of coenzyme Q10, influences markers related to blood clotting and inflammation. Our study was a well-structured, randomized, placebo-controlled trial involving 36 patients with APS, where we administered 200 mg of ubiquinol daily for one month.

We found that supplementation with ubiquinol notably improved the function of blood vessels and reduced the expression of prothrombotic and inflammatory markers present in monocytes. This suggests that ubiquinol plays a role in reducing the risk of blood clots by enhancing endothelial function and dampening inflammatory responses.

Moreover, our results revealed a significant decrease in harmful molecules and a shift in mitochondrial dynamics, which could further support cardiovascular health. Notably, we also observed positive changes in specific microRNAs and gene expressions linked to atherosclerosis, reinforcing the multifaceted benefits of this treatment.

In summary, ubiquinol has the potential to serve as a beneficial adjunct therapy for managing the thrombotic risks associated with APS, especially given its lack of significant side effects. Our findings indicate that ubiquinol could be a promising option for patients seeking to improve their overall condition related to blood clotting.

8.3

Returned to normal

Most Useful Review

I bought this owing to a family member's arrhythmia symptoms. After taking one tablet daily for a week but stopping on the third day, my elevated blood pressure normalised, and I no longer experienced shortness of breath or chest pain.

Atrial Fibrillation

Ongoing atrial fibrillation

Most Useful Review

I’ve taken Co-Enzyme Q10 for decades, but I've had several serious atrial fibrillation events since turning 50, yet initially, I was unaware of what it truly was. After years of inconsistencies and a hospitalisation, my cardiologist showed concern over my thyroid medication causing unintended effects on my heart. Despite the ups and downs, I continue with Q10, hoping for better results.

Breast Cancer

MitoQ effectively inhibits breast cancer

Redox-crippled MitoQ potently inhibits breast cancer and glioma cell proliferation: A negative control for verifying the antioxidant mechanism of MitoQ in cancer and other oxidative pathologies.

Most Relevant Research

We explored the effects of MitoQ, a specialized form of coenzyme Q10 that targets mitochondria, specifically in the context of breast cancer. This intriguing compound has shown promise as an antimetastatic agent, particularly in triple-negative breast cancer, which can be particularly aggressive. In our analysis, we observed that MitoQ had the ability to inhibit tumor growth and reduce tumor cell proliferation in preclinical models and various breast cancer cells.

To further investigate the underlying mechanisms of MitoQ's effectiveness, we introduced a modified version called dimethoxy MitoQ (DM-MitoQ). This alternative does not engage in redox-cycling, a process through which MitoQ would normally combat reactive oxygen species, thereby allowing us to compare its effects directly. Surprisingly, DM-MitoQ demonstrated slightly more potency in inhibiting cancer cell growth than MitoQ itself.

However, both compounds were effective in impairing mitochondrial function, which suggests that regardless of their antioxidant capabilities, the inhibition of mitochondrial energy production plays a crucial role in limiting cancer cell proliferation. Our findings indicate that MitoQ may not solely rely on its antioxidant properties to exert its effects, which could guide future research and therapeutic strategies.

In conclusion, we established that MitoQ significantly impacts breast cancer cell growth, and its analog DM-MitoQ serves as a useful tool for understanding the mechanisms involved. This work emphasizes the complexity of how targeting mitochondrial function can offer potential avenues for cancer treatment.

8.8

Important during radiation

Most Useful Review

My doctor advised against Ubiquinol during my radiation treatment for breast cancer, as it could interfere with the radiation's purpose of killing unhealthy cells. I recognised the importance of this supplement in maintaining cell health and plan to take it post-radiation to support my recovery and prevent cancer recurrence.

Cancer

Ubiquinol aids radiation gut health

Gastroprotective and microbiome-modulating effects of ubiquinol in rats with radiation-induced enteropathy.

Most Relevant Research

In a fascinating exploration of how ubiquinol may aid in managing cancer-related issues, we investigated its effects on radiation-induced enteropathy—a condition that can severely impact patients undergoing radiotherapy. Using a well-structured study design, we divided male albino rats into four groups: one that received only radiation, and three others that received varying treatments with ubiquinol either before or after exposure to radiation.

Our findings revealed that the rats treated with ubiquinol showed marked improvements in gut health when compared to those that only experienced radiation. We saw indications of enhanced healing in their intestinal tissues, including the recovery of important cells and reduced inflammation markers. Notably, the gut microbiomes of the ubiquinol-treated groups began to resemble those of healthy control rats, indicating that this treatment may help restore balance to the gut flora disrupted by radiation.

This research highlights the potential of ubiquinol not only to protect the gut from radiation damage but also to support overall health in cancer patients by aiding in the recovery of gut microbiota diversity. It seems that ubiquinol could indeed play a significant role in enhancing the quality of life for individuals undergoing cancer treatments, particularly those affected by gastrointestinal side effects.

8.8

Supports cell health

Most Useful Review

My doctor advised against taking this during radiation for breast cancer, as the purpose of radiation is to destroy cells, while Ubiquinol strengthens them. I realised the seriousness of this and plan to take Ubiquinol post-radiation to maintain healthy cells and prevent cancer from returning. I have encouraged my daughter to use it for her health as well.

Therapeutic Effects of Coenzyme Q10 in the Treatment of Ischemic Stroke.

Most Relevant Research

We explored how ubiquinol, a form of coenzyme Q10, may help in treating ischemic stroke. The brain is particularly vulnerable after a stroke due to oxidative stress, which can lead to further damage. Thus, the potential of antioxidants like ubiquinol becomes very interesting.

Recent studies suggest that ubiquinol can protect the brain in several ways. It works against oxidative stress, inflammation, and cell death, potentially offering a multi-faceted approach to treating ischemic stroke. Evidence has been gathered from multiple angles—laboratory experiments, animal studies, and clinical observations—to highlight these protective effects.

Our findings emphasize the promising role of ubiquinol in neuroprotection following ischemic stroke. Given the significant deficiency of its reduced form in the brain, ubiquinol could serve as a valuable candidate for treatment and prevention strategies moving forward.

Vital supplement for recovery

Most Useful Review

Five years ago, after experiencing heart failure and a triple bypass, I was prescribed statins. I later discovered the importance of Ubiquinol for combating the side effects of statin use and aiding in cardiac and stroke recovery. Its numerous benefits for heart health are backed by extensive research.