Life Extension DHEA

Vitamin E reduces hot flashes

Questionable

Based on 4 Researches

Yousefi-Nodeh H, Farshbaf-Khalili A, Sadeghzadeh Oskouei B, Jafarilar-Aghdam N, Kazemi-Zanjani N, et al. Curcumin and vitamin E improve hot flashes, lipid profile, and fasting blood glucose without any detrimental effect on the liver and renal function in postmenopausal women: A triple-blind placebo-controlled clinical trial. Health Care Women Int. 2024;45:1184. doi:10.1080/07399332.2022.2117815

We conducted a study with eighty-four postmenopausal women to see how vitamin E affects hot flashes, among other health markers. The participants were divided into three groups and received either Vitamin E, Curcumin, or a placebo for eight weeks.

Our findings revealed that vitamin E significantly reduced the frequency of hot flashes by nearly one-third compared to those taking the placebo. This reduction was accompanied by improvements in several health indicators, including lower serum triglyceride levels and enhanced high-density lipoprotein (HDL) cholesterol.

Furthermore, vitamin E also showed positive effects on liver health markers. Overall, it appears that vitamin E is effective not only in alleviating hot flashes but also in improving some aspects of the lipid profile in postmenopausal women, without adverse effects on liver or kidney function.

Symptoms alleviated

Most Useful Review

195 people found this helpful

I purchased selenium from iHerb based on a friend's recommendation due to the high levels of healthy minerals found in centenarians, especially selenium. Our Selenium Super Complex offers three forms of selenium and vitamin E for health and longevity, which is essential for me at my age, dealing with menopause and hot flashes. Since using this complex, symptoms like hot flashes, weakness, and dizziness have disappeared. I realised this complex assists the body in combating oxidative damage. You only need to take it once a day; there are 100 capsules in a jar, sufficient for three months.

Updated: Mar 2026

Atrial Flutter details

Effective heart support

3 people found this helpful

I take to heart that I have atrial fibrillation and supplement with magnesium and selenium. Initially, while only on the cardiologist's medications, I experienced several episodes of increased arrhythmia. However, after incorporating magnesium and selenium, I haven't had any issues. I really like the Life Extension products, especially as they include vitamin E, which has anti-inflammatory properties.

Cardiovascular Disease details

Selenium aids heart recovery post-MI

Based on 20 Researches

Li T, Liu X, Yang B, Wang Z, Chen Y, et al. Selenium-loaded porous silica nanospheres improve cardiac repair after myocardial infarction by enhancing antioxidant activity and mitophagy. Free Radic Biol Med. 2025;232:292. doi:10.1016/j.freeradbiomed.2025.03.004

This study focused on how selenium-loaded porous silica nanospheres (Se@PSN) could help repair the heart following a myocardial infarction (MI). These tiny particles are designed to neutralize harmful molecules called reactive oxygen species, which play a significant role in heart damage during MI.

We found that Se@PSN not only reduces cellular damage but also promotes the production of protective antioxidant proteins. By enhancing mitochondrial function, these nanospheres could potentially preserve heart function after an MI, demonstrating promising results for future treatments.

Excellent antioxidant

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1 people found this helpful

Selenium is crucial for healthy heart function, thyroid health, and immunity. Under my endocrinologist's guidance, I've consistently taken selenium courses, yielding excellent results without hormone therapy. It serves as a potent antioxidant, enhancing vitality and promoting youthfulness.

Updated: Mar 2026

Chest Pain details

Chest pain alleviation

101 people found this helpful

My endocrinologist prescribed selenium plus vitamin E and kelp to support my thyroid. After three months, the chest pain I experienced before my cycle has stopped, and an ultrasound showed a reduction in size of my thyroid issues.

Allergies details

Selenium nanoparticles reduce allergies

Based on 13 Researches

Xie B, Zeng D, Yang M, Tang Z, He L, et al. Translational Selenium Nanoparticles to Attenuate Allergic Dermatitis through Nrf2-Keap1-Driven Activation of Selenoproteins. ACS Nano. 2023;17:14053. doi:10.1021/acsnano.3c04344

We examined how selenium, a trace element known for its role in health, can help those suffering from allergic dermatitis. In our exploration, we focused on how selenium nanoparticles, specifically designed for easier manufacturing and use, can activate the body's natural defenses against allergies.

The study highlighted how selenium impacts allergic reactions by enhancing the production of selenoproteins, which are crucial in regulating inflammation and oxidative stress. We saw that these selenium nanoparticles effectively inhibited mast cell activation. Mast cells are known to release substances that can trigger allergic reactions, so by reducing their activation, the potential for severe allergic responses decreased.

Additionally, through a series of experiments on allergic mouse models, we confirmed the nanoparticles increased selenium levels in the skin, which led to a reduction in inflammatory cells and mast cell activation. The results indicated significant therapeutic benefits, providing a promising avenue for managing allergic reactions.

Ultimately, this study not only demonstrates the innovative use of selenium nanoparticles in treating allergies but also emphasizes the importance of scaling up their production for broader clinical application.

Enhanced strength observed

Most Useful Review

2 people found this helpful

This is a good form of selenium. I experienced no allergies or gastrointestinal issues. While it may be too soon to speak definitively, I feel much stronger and no longer feel like a "broken trough." The small capsules are easy to swallow, and I will continue taking them. I recommend it to everyone.

Updated: Mar 2026

Hyperthyroidism details

Recently, I had issues with hyperthyroidism, and this supplement has rapidly stabilised my symptoms. I take it in the morning with Vitamin D and noticed improvements almost immediately. It’s a great detox for the thyroid.

Lung Cancer details

Selenium compound inhibits lung tumors

Zhang Y, Chen Y, Wang B, Cai Y, Zhang M, et al. A novel selenium nanocomposite modified by AANL inhibits tumor growth by upregulating CLK2 in lung cancer. Bioorg Chem. 2024;148:107459. doi:10.1016/j.bioorg.2024.107459

We explored the effectiveness of a novel selenium nanocomposite, AANL-SeNPs, in treating lung cancer. This innovative compound, created from a natural ingredient, demonstrated significant inhibition of lung cancer cell growth in various cell lines, showing up to a 67% reduction in viability.

Furthermore, AANL-SeNPs slowed tumor growth in live models and appeared safe for normal cells. While promising, our findings indicate that although AANL-SeNPs upregulate the protein CLK2 and can enhance therapeutic response, further studies are needed to fully understand its potential.

Anti-cancer benefits

Most Useful Review

The king of anti-cancer must be consumed; I've already had three bottles.

Updated: Mar 2026

Prostate Cancer details

Selenium nanoparticles show promise

Based on 17 Researches

Bissardon C, Proux O, Gazze SA, Filhol O, Toubhans B, et al. Intracellular Fate of Sub-Toxic Concentration of Functionalized Selenium Nanoparticles in Aggressive Prostate Cancer Cells. Nanomaterials (Basel). 2023;13. doi:10.3390/nano13232999

We explored the impact of selenium nanoparticles, known for their potential anti-cancer properties, on aggressive prostate cancer cells, specifically the PC-3 line. The study focused on understanding how sub-toxic levels of selenium functionalized nanoparticles affect cell proliferation and their intracellular behavior.

By utilizing advanced imaging techniques and careful cryopreparation, we aimed to preserve the integrity of the cancer cells while analyzing the distribution of these nanoparticles within them. Our findings revealed that nanoparticles coated with bovine serum albumin (BSA) reduced the migration capability of the cancer cells more effectively than those coated with chitosan.

This difference may be attributed to the BSA coating's ability to prevent harmful interactions with the cell membranes, which in turn limits the generation of reactive oxygen species that can damage cells. Most intriguingly, we observed that these selenium nanoparticles localized in both the mitochondria and lysosome-related organelles within the cells. The presence of nanoparticles in the mitochondria might explain the significant reduction in the PC-3 cells' ability to proliferate.

Overall, our investigation highlights the promising role selenium nanoparticles can play in cancer treatment strategies, providing valuable insights for further research into their cytotoxic mechanisms against prostate cancer.

7.5

Prostate support

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1 people found this helpful

This product works wonderfully, especially when combined with zinc, enhancing immunity and benefiting prostate health, alongside supplements like pumpkin seeds.

Updated: Mar 2026

Sleep Apnea details

Examined antioxidants in sleep apnea

Saruhan E, Sertoglu E, Unal Y, Bek S, Kutlu G. The role of antioxidant vitamins and selenium in patients with obstructive sleep apnea. Sleep Breath. 2021;25:923. doi:10.1007/s11325-020-02207-w

We examined the levels of selenium and key vitamins in patients suffering from obstructive sleep apnea (OSA) without additional health issues. Our study, involving 146 subjects split into different OSA severity levels, aimed to understand how these antioxidants might play a role in OSA's impact on health.

Interestingly, we found that higher concentrations of selenium and vitamin A appeared to bolster the body’s defense against OSA. Although our findings suggest potential benefits, it's important to note that antioxidants alone should not replace conventional treatments for OSA.

Enhanced energy levels

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5 people found this helpful

This complex is an effective dietary supplement for my age-related thyroid issues. It supports the thyroid gland, leading to healing and rejuvenation. I categorically abstain from hormones and rely on natural complexes. My sleep has normalised, which feels like a gift during menopause. The uncontrolled appetite has subsided, and I have noticed a significant improvement in my overall mood—both physical and mental. I am very satisfied and highly recommend it to older women.

Updated: Apr 2025

Abscess details

I take this selenium with iodine, and it helps me considerably; the cyst in my mammary glands has decreased since I started taking it.

Asthma details

Selenium intake boosts lung function

Based on 8 Researches

Jiang H, Yang G, Chen J, Yuan S, Wu J, et al. The correlation between selenium intake and lung function in asthmatic people: a cross-sectional study. Front Nutr. 2024;11:1362119. doi:10.3389/fnut.2024.1362119

This study explored how selenium intake relates to lung function in people with asthma. We analyzed data from 4,541 participants in a national survey using various statistical methods. Our findings showed a positive connection between higher selenium intake and better lung function, particularly in forced vital capacity and forced expiratory volume. We noted that to potentially enhance respiratory health, asthma patients could benefit from consuming between 137.65 mcg and 200 mcg of selenium daily, while also being cautious of any adverse effects.

Regulates thyroid function

Most Useful Review

The selenium in this supplement serves as an antioxidant, reducing oxidative stress, and may help in cancer protection, boosting immunity, enhancing blood circulation, and reducing the likelihood of cardiovascular problems while easing asthma symptoms.

Updated: Mar 2026

Autoimmune Disorder details

Selenium aids Graves' orbitopathy treatment

Questionable

Based on 17 Researches

Sharabati I, Qafesha RM, Hindawi MD, Amro S, Ayesh BM. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials. Clin Endocrinol (Oxf). 2024;101:669. doi:10.1111/cen.15128

We explored how selenium supplementation might help individuals suffering from Graves' orbitopathy, an autoimmune disorder linked to thyroid dysfunction. Our approach involved a systematic review and meta-analysis that assessed results from four randomized controlled trials.

The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.

We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.

Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.

Improved skin health

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256 people found this helpful

Great supplement! I’m currently on my second jar, as advised by a nutritionist based on test results. After a short time, she observed that my skin became incredibly smooth, with cracks and dryness disappearing. My chronic runny nose and congestion have also resolved, leading to an overall improvement in my condition. Selenium is advised to take in courses for those with thyroid issues. I will order more!

Updated: Mar 2026

We investigated the impact of vitamin E on treating frequent and severe nocturnal leg cramps. Patients received 100 I.U. of d, alpha-tocopheryl acetate three times daily before meals.

Remarkably, nearly all participants reported prompt relief from their symptoms. This group included 24 patients with leg cramps and a couple with "restless legs" syndrome.

Given that nocturnal leg cramps can be distressing and treatments are often unsatisfactory, these findings are particularly noteworthy.

Prevents convulsions

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I used to wake up with painful leg cramps, but after taking selenium, I've forgotten what those convulsions feel like. I will continue this for prevention purposes; it's truly made a difference for me.

Updated: Mar 2026

Low Libido details

This product increases sexual desire.

Pelvic Pain details

Vitamin E reduces menstrual pain

Based on 17 Researches

Ziaei S, Zakeri M, Kazemnejad A. A randomised controlled trial of vitamin E in the treatment of primary dysmenorrhoea. BJOG. 2005;112:466.

We investigated whether vitamin E could help with primary dysmenorrhea, a common cause of pelvic pain for young women. In our study, 278 girls aged 15-17 took either vitamin E or a placebo before and during their menstrual periods.

Results showed that those taking vitamin E experienced significantly less pain and shorter pain duration compared to the placebo group. There was also a notable reduction in menstrual blood loss. This suggests that vitamin E may be a beneficial option for managing menstrual discomfort.

Thyroid discomfort relief

Most Useful Review

2 people found this helpful

I consistently alternate between different brands, and a dosage of 200 is perfect. Although it's advised not to take selenium constantly, I've noticed my eyes have returned to normal, and the heaviness, pain, and pressure in my thyroid at night have subsided.

Updated: Mar 2026

Adrenal Gland Disorder details

Effective for thyroid

Excellent! All the best types of Selenium! Experts suggest that this important mineral can benefit us, especially now that our soil is depleted and the food we consume may lack this element. Medical literature supports that Selenium, along with Co-enzyme Q-10, is crucial for telomere support in maintaining healthy tissue for anti-ageing. Selenium aids in DNA synthesis and protects against oxidative damage, among other benefits. This composition contains various forms of selenium, which may affect individuals differently compared to other supplements. At a dosage level of 200 mcg, taking more than one capsule daily may not be beneficial and could exceed recommended levels. I take it for my thyroid, adrenal gland disorder, and immune support, and it works perfectly with no side effects. Life Extension is renowned for its quality ingredients, so I highly recommend it for anyone needing Selenium!

Arthritis details

Very successful combat

4 people found this helpful

Primarily, I use this product to combat arthritis and it has, as far as I can tell, been very successful. After many years of use, I believe it has helped me manage the after-effects of cancer and the persistent challenges of arthritis at my age. Overall, it's a powerful product that works gradually.

Candidiasis details

Selenium's antifungal potential explored

Based on 9 Researches

de Siqueira VM, da Silva BGM, Passos JCDS, Pinto AP, da Rocha JBT, et al. (MeOPhSe)2, a synthetic organic selenium compound, inhibits virulence factors of Candida krusei: Adherence to cervical epithelial cells and biofilm formation. J Trace Elem Med Biol. 2022;73:127019. doi:10.1016/j.jtemb.2022.127019

We delved into the potential of a synthetic organic selenium compound, known as p,p'-methoxyl-diphenyl diselenide, or (MeOPhSe), to combat candidiasis, particularly focusing on its effects on Candida krusei. This research is important because Candida species can lead to both mild and serious infections, and finding effective treatments is crucial.

Our study demonstrated that (MeOPhSe) is non-toxic to human cells, such as cervical epithelial and fibroblastic cells, and has a notable antifungal effect. We observed that it inhibited the growth of C. krusei in a dose-dependent manner, altering its growth pattern and extending the length of its lag phase. Most significantly, we found that this compound reduced the ability of both C. krusei and C. albicans to adhere to human cells, a critical step in the infection process.

The reductions we measured were substantial: C. krusei adherence dropped by 37.24%, while C. albicans showed a 32.84% reduction, both being statistically significant. Interestingly, both species responded similarly to (MeOPhSe), highlighting its potential as a broad-spectrum antifungal agent against various Candida infections.

Overall, our findings suggest that (MeOPhSe) holds promise as an antifungal treatment targeting the virulence factors of different Candida species, paving the way for new treatment options in battling candidiasis.

7.5

Visible rash improvement

Most Useful Review

Unleavened! A good preparation, yeast-free, which is essential for those with thrush. My wife, our 18-year-old child, and I consume it in courses. The results for my teenager are evident immediately—the rashes on their face fade away, and they seem more energetic. However, continual consumption isn't advisable, as noted. Therefore, we take it in courses every 4-5 months.

Updated: Apr 2025

Celiac details

Significant improvement

I've been taking this selenium supplement for Hashimoto's, gluten-free and only one tablet a day. My index has dropped significantly, and I can confidently say it is safe and effective.

Cold Sores details

Effective against colds

8 people found this helpful

I find this form of selenium very effective. At the first sign of a cold, I take it with zinc and higher doses of vitamins C and D, and by morning I feel completely well! It’s crucial to pair it with iodine as selenium helps with iodine absorption.

Hypertension details

Positive health trend

3 people found this helpful

The selenium from the reputable American company Life Extension has impressed me. They have been dedicated to health-related research since 1980. Their products, including this selenium complex, appeal to me because of their scientific basis. I trust their formulation as it contains three forms of selenium and vitamin E to enhance absorption. At 55, with hypertension and other conditions, my endocrinologist recommended selenium. Since starting this supplement, I've noticed improvements in my thyroid hormone tests, lowered blood pressure, and a steadier heart rate. Furthermore, I also take vitamin D3, Omega, and coenzyme Q10.

Perfectly! This supplement helps me heal psoriasis spots on my skin more rapidly. Personally, I noticed the effect within a week; the itching diminished and the condition of my spots improved. Additionally, I've felt much more cheerful overall. I plan to purchase it again.

Psoriasis details

Common Cold details

Vitamin E's complex effects on colds

Based on 5 Researches

Hemilä H, Virtamo J, Albanes D, Kaprio J. The effect of vitamin E on common cold incidence is modified by age, smoking and residential neighborhood. J Am Coll Nutr. 2006;25:332.

We examined how vitamin E affects common cold incidence among different groups. In our study involving over 14,500 participants, we found that older smokers living in cities benefited from vitamin E, showing a 46% reduction in cold risk.

In contrast, those who smoked more and lived in rural areas faced a higher cold risk with vitamin E intake. This suggests that vitamin E's impact can vary greatly based on age, smoking habits, and where one lives, indicating the need for cautious public health guidelines regarding vitamin E supplementation.

Cold relief

Most Useful Review

8 people found this helpful

A good form of selenium! At the first sign of a cold, together with zinc and higher doses of vitamins C and D, I found that I felt completely well by morning! Additionally, selenium is essential when taking iodine as it acts as a cofactor.

Updated: Apr 2025

Hashimoto details

Selenium effective in Hashimoto's treatment

Peng B, Wang W, Gu Q, Wang P, Teng W, et al. Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis. Front Endocrinol (Lausanne). 2024;15:1445878. doi:10.3389/fendo.2024.1445878

We examined the impact of selenium supplements on thyroid autoantibody levels in patients with Hashimoto's thyroiditis.

In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.

However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.

This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.

7.5

Reduced antibodies

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27 people found this helpful

Great selenium supplement! I use this because I have Hashimoto's thyroiditis, and selenium aids in reducing thyroid antibodies. This supplement contains three forms of selenium, ensuring its effectiveness. It also includes vitamin E, enhancing selenium absorption, and the price on iHerb is fantastic!

Updated: Mar 2026

Menopause details

Cognition enhancement in menopause

Based on 20 Researches

da Rocha JT, Pinton S, Mazzanti A, Mazzanti CM, Beckemann DV, et al. Diphenyl diselenide ameliorates cognitive deficits induced by a model of menopause in rats. Behav Pharmacol. 2012;23:98. doi:10.1097/FBP.0b013e32834ed849

We investigated how diphenyl diselenide, a synthetic selenium compound, affects cognitive performance in a rat model of menopause. Female rats underwent ovariectomy, mimicking hormone loss in postmenopausal women, and were treated with diphenyl diselenide daily for 30 days.

The results showed that this treatment improved cognitive abilities, as evidenced by better performance in behavioral tests and prevented the increase of acetylcholinesterase activity.

Overall, diphenyl diselenide appears to hold promise in mitigating cognitive decline linked to menopause.

Restored hormone levels

Most Useful Review

102 people found this helpful

Brought my hormone levels back to normal. I take DHEA alongside my infertility hormone treatments. At 28, I was diagnosed with premature ovarian deficiency and was heading toward early menopause based on my hormone levels. After a few weeks of taking 75mg daily, my hormone levels returned to the normal range for my cycle! No bad side effects noted. While my sex drive decreased after starting other hormone injections, I’ve experienced no other adverse effects. The pills are small and easy to swallow, and they don't upset my stomach.

Updated: Mar 2026

Rash details

It includes vitamin E and three forms of selenium, and I am thrilled to report that the rash on my chin has vanished, leaving my face feeling much cleaner.

Selenium and vitamin E are very beneficial for those with rheumatoid arthritis.

Rheumatoid Arthritis details

Excellent quality; it offers permanent protection for all our body’s cells against the detrimental effects of free radicals. This helps prevent premature aging of tissues, loss of hair, teeth, and dryness of the skin. Selenium reduces the risks of poisoning, heart and vascular issues, and lowers the likelihood of stroke and Alzheimer’s disease.

Stroke details

Positive dynamics observed

Weight Loss details

7 people found this helpful

I have hypothyroidism and took this jar as I learned selenium helps regulate the thyroid gland while on a low-dose hormonal therapy. After a month, I noticed some changes; the main issue being excess weight and fluid retention. My doctor advised I lose weight to avoid increasing my hormone dosage, and despite training, it wasn’t effective. I also bought green tea extract for puffiness. I can say there’s positive progress; my weight is normalising, and my jeans fit more comfortably. Though the puffiness is still stubborn, this isn’t a weight loss product; it's helping my body return to normal.

Blood Clot details

Vitamin E may reduce blood clots

Based on 24 Researches

Glynn RJ, Ridker PM, Goldhaber SZ, Zee RY, Buring JE. Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women's Health Study. Circulation. 2007;116:1497.

We investigated whether vitamin E supplementation affects the risk of blood clots, specifically venous thromboembolism (VTE), in women. The Women's Health Study involved nearly 40,000 women who received either vitamin E or a placebo over more than ten years.

Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.

Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.

Raises selenium levels

Most Useful Review

10 people found this helpful

This is an excellent selenium supplement! My blood test showed that my selenium levels doubled. I didn't expect this since I didn't take it every day. Take it without hesitation; the effectiveness is undeniable.

Updated: Mar 2026

Blurred Vision details

Selenium shows short-term benefits only

Wang C, Qiao J, Liu S, Piao S, Zhou Y, et al. Selenium in the treatment of mild-to-moderate Graves' orbitopathy: a 5-year prospective controlled cohort study. Endocrine. 2024;84:1072. doi:10.1007/s12020-023-03672-5

Our study examined the effects of selenium in treating mild-to-moderate Graves' orbitopathy (GO) over five years. We followed 74 patients who took selenium or a placebo for six months, tracking their symptoms and quality of life.

Initially, selenium showed promise by reducing symptoms like blurred vision, with significant improvements over six months. However, when we looked at long-term outcomes after five years, both groups had similar results, indicating that while selenium may help in the short term, it doesn't contribute to lasting changes.

7.5

Vision improvement

Most Useful Review

1 people found this helpful

Super Selenium is worth trying due to its effectiveness, particularly the combination with vitamin E, which enhances absorption and speeds up the benefits. Selenium is vital for vision health and serves as an excellent antioxidant, boosting overall immunity. The quantity and price are also fantastic.

Updated: Mar 2026

Bone Pain details

4 people found this helpful

This inexpensive capsule has helped tremendously. I'm experiencing less pain all over and am not as sore as before. It’s helping with whatever discomfort I'm having, possibly related to bones or ligaments.

Vitamin E mitigates respiratory damage

Cold details

Shu Z, Qing S, Yang X, Ma P, Wu Y, et al. A molecular toxicological study to explore potential health risks associated with ultrafine particle exposure in cold and humid indoor environments. Ecotoxicol Environ Saf. 2025;289:117638. doi:10.1016/j.ecoenv.2024.117638

We investigated how exposure to ultrafine particles (UFPs) in cold and humid environments impacts respiratory health. Using a controlled study with male Balb/c mice, we found that exposure to carbon black nanoparticles worsened lung function and increased inflammation and oxidative stress.

Notably, the combination of UFPs and cold-humid conditions intensified these adverse effects. However, when we administered Vitamin E, it helped reduce these harmful impacts. This suggests that Vitamin E could be a potential protector against indoor air pollutants, offering insights for healthier living spaces.

Cold symptom relief

Most Useful Review

8 people found this helpful

I find this selenium supplement effective. When I feel the onset of a cold, I take it alongside zinc and vitamins C and D in higher doses, and by morning, I already feel well. Iodine needs selenium as a cofactor, which is beneficial for overall health.

Updated: Mar 2026

Depression details

Selenium's potential in depression treatment

Garcia CS, Besckow EM, da Silva Espíndola CN, D'Avila Nunes G, Zuge NP, et al. Antidepressant-Like Effect of a Selenoindolizine in Mice: In Vivo and In Silico Evidence for the Involvement of the Serotonergic 5-HT Receptors. ACS Chem Neurosci. 2022;13:1746. doi:10.1021/acschemneuro.2c00129

This study explored how a selenium-containing compound, SeI, impacts depression-like behavior in mice. During behavioral tests, this compound reduced immobility, signaling an antidepressant-like effect without affecting movement.

Notably, blocking specific serotonin receptors changed the results, indicating the serotonergic system's involvement. With a low potential for side effects, SeI shows promise for developing new treatments for major depressive disorder (MDD).

However, it's important to note this research was conducted in mice, so effects in humans remain unconfirmed.

Reduced anxiety

Most Useful Review

After a month of taking selenium, I’ve found that my anxiety, depression, and insomnia have subsided. I feel much lighter and more at ease.

Updated: Mar 2026

Food Poisoning details

Effect of SeNPs on ZEA toxicity

Based on 4 Researches

Qiao L, Chang J, Yang G, Deng T, Liu P, et al. Prophylactic supplementation with selenium nanoparticles protects against foodborne toxin zearalenone-induced intestinal barrier dysfunction. Ecotoxicol Environ Saf. 2024;284:116914. doi:10.1016/j.ecoenv.2024.116914

We explored the protective effects of selenium nanoparticles (SeNPs) against the harmful impacts of zearalenone (ZEA), a toxin from grains that can disrupt gut health. In a controlled setting, we observed that ZEA damages intestinal cells, leading to inflammation and increased permeability.

Our findings showed that SeNPs can counteract this damage by enhancing antioxidant activity and improving gut microbiota balance. Despite these promising results, it’s crucial to note that the effectiveness of SeNPs in humans still requires further investigation.

Supports thyroid health

Most Useful Review

49 people found this helpful

This supplement is effective for supporting the endocrine system. Selenium is crucial for our health, and due to dietary insufficiencies, I find it necessary. This product aids in the absorption of iodine, which is vital for thyroid function. I take it daily as a prevention against hyperthyroidism and recommend it to those with similar concerns.

Updated: Mar 2026

Heart Attack details

Selenium nanoparticles for heart health

Based on 29 Researches

Sun Q, Ma H, Zhang J, You B, Gong X, et al. A Self-Sustaining Antioxidant Strategy for Effective Treatment of Myocardial Infarction. Adv Sci (Weinh). 2023;10:e2204999. doi:10.1002/advs.202204999

We examined the role of selenium in treating myocardial infarction (MI), a major cause of death worldwide that can lead to serious heart problems. The study focused on how this antioxidant works across different phases of a heart attack, where harmful reactive oxygen species (ROS) play a significant role in worsening the condition.

Our findings highlighted a new approach using selenium-embedded nanoparticles, which are specially designed to act as antioxidants at various stages of MI. This innovative method allows for selective ROS elimination when it's most needed, leading to impressive recovery outcomes for the heart.

Throughout the research, it became clear that these nanoparticles help protect vital functions in heart cells by reducing cell death, inflammation, and scar tissue, while also encouraging new blood vessel growth. Overall, this self-sustaining antioxidant strategy shows great potential, not just for treating heart attacks but also inspiring therapies for other ischemic conditions.

Improved energy levels

Most Useful Review

4 people found this helpful

The complex is effective! I began taking it on the advice of a nutritionist to restore my thyroid function, addressing fatigue, muscle weakness, and heart issues. Almost immediately, I felt better; my energy increased, hair loss decreased, and my heartbeat was more stable. I recommend this essential vitamin for optimal body performance. Please like if you find this helpful.

Updated: Apr 2025

Hypothyroidism details

Selenium benefits Hashimoto's patients

Based on 20 Researches

Huwiler VV, Maissen-Abgottspon S, Stanga Z, Mühlebach S, Trepp R, et al. Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Thyroid. 2024;34:295. doi:10.1089/thy.2023.0556

We explored the effects of selenium supplementation in patients suffering from Hashimoto thyroiditis (HT), a leading cause of hypothyroidism. By analyzing multiple randomized controlled trials, we aimed to see how selenium might impact thyroid function, particularly focusing on thyroid-stimulating hormone (TSH) levels and thyroid antibodies.

Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.

Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.

However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.

7.5

Reduced thyroxine dosage

Most Useful Review

17 people found this helpful

I took this medication due to my lack of thyroid gland, and synthetic thyroxine isn't well absorbed in my body. After a couple of days on selenium, I experienced tachycardia, sweating, and pressure episodes, catching an overdose. Clearly, selenium worked, as it improved the deiodination process in my body, allowing me to reduce my thyroxine dosage. I continue to take selenium and feel well.

Updated: Mar 2026

Urinary Tract Infection details

Positive skin effects

I truly appreciate this powerful complex of selenium and vitamin E that my endocrinologist prescribed, along with other medications. Selenium is an essential trace element, recognised for its antioxidant properties that combat free radicals. This complex features vitamin E along with three formulas: L-selenomethionine, sodium selenite, and selenium-methyl L-selenocysteine. Selenium supports thyroid gland functionality and bolsters the immune system, enhancing the body’s resistance to infections. I consistently take selenium due to my thyroid issues and supplement it with vitamin E every six months for better absorption. I’ve also observed a significant improvement in my skin's dryness and peeling after winter, leaving it feeling rejuvenated.

Bacterial Infection details

Selenium bandages prevent infections

Tran P, Abidi N, Bergfeld N, Shashtri M, Reid TW. Selenium Bandages and Cotton Cloth That Kill Microorganisms in Wounds. Mil Med. 2024;189:179. doi:10.1093/milmed/usae069

We investigated how selenium-infused bandages can help prevent bacterial infections in wounds. By attaching organo-selenium compounds to cotton fabric, we created a bandage designed to kill harmful bacteria, including strains resistant to traditional antibiotics, like MRSA.

In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.

Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.

Quick recovery from infection

Most Useful Review

After a careless dental procedure, I experienced swollen lymph nodes and an infection in the wounds. The dentist suggested strong antibiotics. Instead, I opted for this complex, knowing selenium could help. To my surprise, after two days, I returned to normal, astonishing my dentist. Now, I rely on this Superselenium complex for quick treatment of any infection or chills. Just be cautious with dosages and understand what you're taking.

Updated: Apr 2025

Flu details

Selenium affects flu immunity variably

Ivory K, Prieto E, Spinks C, Armah CN, Goldson AJ, et al. Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults. Clin Nutr. 2017;36:407. doi:10.1016/j.clnu.2015.12.003

We conducted a 12-week study to explore the effects of selenium supplementation on flu immunity in healthy adults aged 50-64. Participants were divided into groups receiving different selenium doses or no selenium at all.

The results indicated that selenium could have both positive and negative impacts on immunity against the flu vaccine, influenced by the amount and type of selenium consumed. This complexity highlights the need for careful consideration of the benefits and risks associated with selenium supplementation in boosting flu immunity.

7.5

No illness reported

Most Useful Review

6 people found this helpful

It works! I drink selenium during flu season to support my immune system. After suffering from coronavirus over the summer and subsequently pneumonia, I now regularly take selenium and zinc. Fortunately, I haven't fallen ill again, even though many at work are currently experiencing colds with runny noses and sneezing.

Updated: Mar 2026

Liver Disease details

Selenium nanoparticles reduce liver toxicity

Based on 29 Researches

Mrwad AA, El-Shafey SE, Said NM. Chitosan-encapsulated selenium nanoparticles alleviate CCl induced hepatotoxicity through synergistically modulating NF-κB and Nrf2 signaling pathways and regulating Bcl-2 and Caspase-3 expression: A comprehensive study with multiple regression analysis. J Trace Elem Med Biol. 2024;86:127563. doi:10.1016/j.jtemb.2024.127563

We investigated how selenium nanoparticles (Se-NPs) and chitosan-encapsulated selenium nanoparticles (Se-CS-NPs) can mitigate liver toxicity induced by carbon tetrachloride (CCl) in rats. In our study, eighty rats were divided into eight groups, including placebo and control.

The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.

Miraculous health improvement

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10 people found this helpful

This is the one to get. I'm so glad I bought this. I realised the symptoms I experienced were due to an unsupported liver that was becoming overwhelmed by daily toxins. I had a serious issue for over six months. I was advised that selenium would help support my liver and enable it to detoxify, and after two weeks of taking this, the major symptoms completely disappeared. It feels like a miracle. Many people may not experience such dramatic health improvements, and I couldn't be happier.

Updated: Mar 2026

Adenoiditis details

Effective selenium treatment

6 people found this helpful

Super selenium active complex is an essential dietary supplement containing vital minerals. I have been using it for four years with excellent results. The composition includes vitamin E, enhancing absorption. I take one tablet daily for two months during meals, which aids uptake. The tablets are small and easy to swallow, with high-quality packaging and a neutral taste. I have elevated antibodies to the thyroid gland, and after using Selenium, the antibodies decreased significantly, alleviating my sore throat symptoms and improving my overall health. It is crucial for anyone with a selenium deficiency.

Breast Cancer details

Selenium compounds may fight breast cancer

Based on 18 Researches

Radomska D, Czarnomysy R, Szymanowska A, Radomski D, Chalecka M, et al. Di- and Triselenoesters-Promising Drug Candidates for the Future Therapy of Triple-Negative Breast Cancer. Int J Mol Sci. 2024;25. doi:10.3390/ijms25147764

We set out to explore the effects of selenium-containing compounds on breast cancer cells, particularly focusing on their potential as treatments. Our research involved testing several novel selenoesters on two breast cancer cell lines, MCF-7 and MDA-MB-231, to understand how these compounds can impact cell growth and survival.

What we found was quite promising. The selenoesters showed significant cytotoxic effects, meaning they can kill cancer cells effectively, even at very low doses. We observed that these compounds triggered important processes that lead to cell death, specifically by activating pathways that make cells undergo apoptosis, or programmed cell death.

The mechanisms at play include both the extrinsic and intrinsic apoptosis pathways, which means they are working from multiple angles to combat cancer. Additionally, these compounds also activate autophagy, a process that helps clear out damaged cells and contributes to the overall effectiveness of the treatment.

In summary, our findings suggest that these selenium-based compounds could be valuable candidates for future breast cancer therapies, worth considering in the ongoing fight against this disease.

Treats breast cancer

Most Useful Review

Everyone liked it! We use it alongside cruciferous plants for breast cancer treatment. The quality and dosage suit us well, and there are no side effects. 👍

Updated: Mar 2026

Cancer details

Selenium drug shows selective toxicity

Based on 41 Researches

Qin X, Guo J, Li H, He H, Cai F, et al. Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy. Adv Sci (Weinh). 2025. doi:10.1002/advs.202412062

We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.

The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.

Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.

7.5

Defence against cancer

Most Useful Review

5 people found this helpful

Selenium is indispensable for maintaining health, based on its role in protecting against cancer through its antioxidant activity. A daily intake has notably increased my immune response and offers protection against harmful metals.

Updated: Apr 2025

Chronic Fatigue Syndrome details

Selenium effects on chronic fatigue

Based on 3 Researches

Shao C, Song J, Zhao S, Jiang H, Wang B, et al. Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Green Tea on Chronic Fatigue Syndrome. Polymers (Basel). 2018;10. doi:10.3390/polym10111269

We studied how selenium-polysaccharides (Se-TP) from green tea could improve chronic fatigue syndrome (CFS) in a rat model. Our experiments revealed that Se-TP significantly enhanced levels of certain substances related to fatigue, indicating improved overall condition. However, while the treatment showed promise in restoring some metabolic markers, the overall efficacy in CFS management remains to be fully affirmed. The changes observed were tied to metabolic pathways involved in steroid hormone biosynthesis and other critical processes.

Strengthened immunity

Most Useful Review

I've been taking the super complex of selenium with vitamin E for a month, and the results are impressive! I've noticed improved skin condition, increased energy, and disappearance of fatigue, along with a stronger immune system.

Updated: Mar 2026

Heart Disease details

Selenium nanoparticles support heart health

Based on 27 Researches

Chen C, Ma J, Duan S, Xue M, Yang Z, et al. Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation. Biomaterials. 2025;318:123119. doi:10.1016/j.biomaterials.2025.123119

We explored how selenium nanoparticles (SeNPs) could help reduce damage from heart attacks, specifically ischemia/reperfusion injury (I/RI). Using a method to create these nanoparticles, we found they possess remarkable properties that combat oxidative stress and inflammation.

SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.

7.5

Improved heart function

Most Useful Review

210 people found this helpful

The finest selenium product! As part of the Super Selenium range, it contains three forms of selenium alongside vitamin E. Selenium aids in the normal function of the thyroid gland and boosts immunity. It also enhances the functioning of the heart and brain.

Updated: Mar 2026

Insomnia details

Excellent implementation after COVID. I began using this on my doctor's recommendation after my family fell ill with COVID. Personally, I experienced lingering insomnia, interrupted sleep, and constant irritability. After taking this selenium product for two months, my sleep has improved. While irritability hasn't completely vanished, my emotional state has levelled off to some extent. If anyone has advice on rehabilitating skin after COVID, please share your insights. Periodic rashes and a poor skin tone have been concerning.

Diabetes details

Selenium aids gestational diabetes management

Based on 21 Researches

Yigit E, Sayar I. Selenium Supplementation and Gestational Diabetes: A Randomised Controlled Trial. J Coll Physicians Surg Pak. 2024;34:561. doi:10.29271/jcpsp.2024.05.561

We explored whether selenium supplementation could improve blood glucose levels in pregnant women with gestational diabetes. In this randomized controlled trial conducted at an Istanbul university, women diagnosed with gestational diabetes received either diet alone or diet plus 200 µg of selenium daily for four weeks.

Findings showed that pregnant women had lower selenium levels compared to healthy counterparts. Those taking selenium experienced a more significant decrease in blood sugar levels than those on diet alone, indicating a beneficial effect of selenium on managing gestational diabetes.

Effective treatment

Most Useful Review

Excellent! This complex preparation is of suitable dosage and provides good results. I take it for diabetes and highly recommend it.

Updated: Mar 2026

Premenstrual Syndrome details

Breast swelling reduced

It is beneficial to take selenium in combination with vitamin E. A preventive dosage of 200 mg is ideal for adults. I took it due to a high TSH level of 4. After taking it, my PMS symptoms subsided and my breasts stopped swelling.

Hair Loss details

Selenium aids hair loss in PCOS

Based on 7 Researches

Razavi M, Jamilian M, Kashan ZF, Heidar Z, Mohseni M, et al. Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome. Horm Metab Res. 2016;48:185. doi:10.1055/s-0035-1559604

We conducted a randomized double-blind, placebo-controlled trial to explore how selenium supplementation may influence hair loss among women with polycystic ovary syndrome (PCOS). In the study, 64 women aged 18-40 received either 200 μg of selenium daily or a placebo for eight weeks.

After the treatment period, we noticed a significant improvement in hair-related issues for those taking selenium. Specifically, alopecia rates dropped from 40.6% in the selenium group to just 9.4% in the placebo group, showing a strong positive effect of the supplement on hair loss. Acne also improved, with a reduction from 46.9% to 12.5%.

Furthermore, women who took selenium supplements exhibited decreased levels of dehydroepiandrosterone (DHEA), hirsutism, and markers of inflammation and oxidative stress. However, it’s important to note that selenium did not show significant effects on some hormonal profiles and other biomarkers. Overall, our findings suggest that selenium can be beneficial for women with PCOS, particularly regarding hair loss and related symptoms.

Improved health

Most Useful Review

28 people found this helpful

I was prescribed this for hyperthyroidism. Surprisingly, my health improved; my hair loss stopped, and I felt more energetic. My friend also found it useful for hair loss. The doctor recommended taking it regularly with meals, as it has a positive effect on thyroid function.

Updated: Mar 2026

High Cholesterol details

Selenium supports cholesterol management

Based on 32 Researches

Dhingra S, Bansal MP. Modulation of hypercholesterolemia-induced alterations in apolipoprotein B and HMG-CoA reductase expression by selenium supplementation. Chem Biol Interact. 2006;161:49.

We investigated how selenium supplementation affects cholesterol levels and the associated molecular changes. Using Sprague-Dawley male rats, we fed them diets supplemented with selenium alongside high cholesterol for three months.

The results showed that while apolipoprotein B levels rose with the cholesterol diet, supplementing with 1 ppm of selenium significantly reduced these levels. Additionally, the expression of HMG-CoA reductase also decreased with selenium supplementation.

Overall, our findings suggest that selenium could offer a supportive role in managing lipid metabolism and high cholesterol.

Selenium deficiency corrected

Most Useful Review

7 people found this helpful

Two years ago, I found I was selenium deficient. Selenium is a super antioxidant that aids thyroid hormone production, crucial for maintenance of function. I found this selenium supplement with 200 micrograms, taking one capsule daily. After two years, my selenium levels are now normal, which brings me great happiness. I highly recommend this high-quality selenium.

Updated: Mar 2026

Acne details