Life Extension DHEA

Selenium nanoparticles reduce allergies

Based on 13 Researches

Translational Selenium Nanoparticles to Attenuate Allergic Dermatitis through Nrf2-Keap1-Driven Activation of Selenoproteins.

Most Relevant Research

We examined how selenium, a trace element known for its role in health, can help those suffering from allergic dermatitis. In our exploration, we focused on how selenium nanoparticles, specifically designed for easier manufacturing and use, can activate the body's natural defenses against allergies.

The study highlighted how selenium impacts allergic reactions by enhancing the production of selenoproteins, which are crucial in regulating inflammation and oxidative stress. We saw that these selenium nanoparticles effectively inhibited mast cell activation. Mast cells are known to release substances that can trigger allergic reactions, so by reducing their activation, the potential for severe allergic responses decreased.

Additionally, through a series of experiments on allergic mouse models, we confirmed the nanoparticles increased selenium levels in the skin, which led to a reduction in inflammatory cells and mast cell activation. The results indicated significant therapeutic benefits, providing a promising avenue for managing allergic reactions.

Ultimately, this study not only demonstrates the innovative use of selenium nanoparticles in treating allergies but also emphasizes the importance of scaling up their production for broader clinical application.

9.5

No allergic reaction

Most Useful Review

This selenium, paired with vitamin E for better absorption, is effective. However, it isn't advisable to take selenium for extended periods; a month on and a break is recommended. It did not cause any allergies.

Hypothyroidism details

Selenium benefits Hashimoto's patients

Based on 21 Researches

Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Most Relevant Research

We explored the effects of selenium supplementation in patients suffering from Hashimoto thyroiditis (HT), a leading cause of hypothyroidism. By analyzing multiple randomized controlled trials, we aimed to see how selenium might impact thyroid function, particularly focusing on thyroid-stimulating hormone (TSH) levels and thyroid antibodies.

Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.

Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.

However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.

9.5

Reduced illness frequency

Most Useful Review

Very good for those suffering from Hashimoto's disease or hypothyroidism. I was frequently unwell, but after using selenium, my health improved remarkably, leading to weight loss without needing thyroxine. This product truly made a difference for me.

Menopause details

Vitamin E reduces hot flashes

The effect of oral capsule of curcumin and vitamin E on the hot flashes and anxiety in postmenopausal women: A triple blind randomised controlled trial.

Most Relevant Research

We conducted a rigorous study to assess how vitamin E affects menopausal symptoms, especially hot flashes. In this triple-blind, randomized controlled trial with 93 postmenopausal women, participants were divided into groups receiving curcumin, vitamin E, or a placebo for eight weeks.

While both curcumin and vitamin E were found to significantly reduce hot flashes, they didn’t show any notable benefits for anxiety, sexual function, or other menopausal symptoms. This suggests that vitamin E may be helpful for hot flashes but not for a broader range of menopause-related challenges.

9.5

Hot flashes relief

Most Useful Review

I purchased selenium from iHerb on my friend's recommendation, as I heard centenarians have high levels of this mineral. Our Selenium Super Complex contains three forms of selenium and vitamin E, which I find important. At my age, menopause brings hot flashes. After taking this complex, my symptoms, including hot flashes, weakness, and dizziness, vanished. I realised this complex aids the body in combating oxidative damage. You need to take it just once a day; there are 100 capsules in a jar, which lasts for three months.

The effect of vitamin E on common cold incidence is modified by age, smoking and residential neighborhood.

Most Relevant Research

We examined how vitamin E affects common cold incidence among different groups. In our study involving over 14,500 participants, we found that older smokers living in cities benefited from vitamin E, showing a 46% reduction in cold risk.

In contrast, those who smoked more and lived in rural areas faced a higher cold risk with vitamin E intake. This suggests that vitamin E's impact can vary greatly based on age, smoking habits, and where one lives, indicating the need for cautious public health guidelines regarding vitamin E supplementation.

9.5

Cold relief

Most Useful Review

A good form of selenium! At the first sign of a cold, together with zinc and higher doses of vitamins C and D, I found that I felt completely well by morning! Additionally, selenium is essential when taking iodine as it acts as a cofactor.

Depression details

After a month of taking selenium, I’ve found that my anxiety, depression, and insomnia have subsided. I feel much lighter and more at ease.

Heart Disease details

Selenium nanoparticles support heart health

Based on 28 Researches

Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation.

Most Relevant Research

We explored how selenium nanoparticles (SeNPs) could help reduce damage from heart attacks, specifically ischemia/reperfusion injury (I/RI). Using a method to create these nanoparticles, we found they possess remarkable properties that combat oxidative stress and inflammation.

SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.

8.8

Improved heart function

Most Useful Review

The finest selenium product! As part of the Super Selenium range, it contains three forms of selenium alongside vitamin E. Selenium aids in the normal function of the thyroid gland and boosts immunity. It also enhances the functioning of the heart and brain.

Hyperthyroidism details

This is a good and effective supplement for supporting the endocrine system. Selenium is a vital trace element for health, yet it is often deficient in our diets, leading to health issues and adversely affecting thyroid function. I use this selenium to support my thyroid and aid iodine absorption, which is impaired without selenium. This supplement features a beneficial active form (selencysteine) and an adequate prophylactic daily dose (200 mg), along with vitamin E, an essential antioxidant. I take this for my hyperthyroidism and recommend it to anyone with similar concerns.

Rash details

I was prescribed this selenium for hyperthyroidism and found it beneficial for everyone, regardless of thyroid issues. A friend also took it for hair loss and nail problems. Since I began using this selenium, the rashes on my face and back have disappeared, and I feel more energetic. My health has improved overall, and my doctor is pleased with my progress. It's best taken with meals, and it lasts for three months. The capsules are small and easy to swallow, and I will continue ordering this complex as it has proven to be the best for me!

Blood Clot details

Vitamin E may reduce blood clots

Based on 24 Researches

Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women's Health Study.

Most Relevant Research

We investigated whether vitamin E supplementation affects the risk of blood clots, specifically venous thromboembolism (VTE), in women. The Women's Health Study involved nearly 40,000 women who received either vitamin E or a placebo over more than ten years.

Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.

Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.

9.5

Boosted immune function

Most Useful Review

Selenium is an essential trace element that is vital for our body's activity, particularly in immune defence and heart health. However, our modern lifestyle often leads to insufficient intake. I bought this for my mother, and she is thrilled with the improvements in her health. I’ve read it’s great for enhancing female beauty too, which is an added bonus. It’s important to take one capsule daily with food or as directed by your doctor, and this formulation contains all three forms of selenium for optimal benefits.

Cancer details

Selenium drug shows selective toxicity

Based on 41 Researches

Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy.

Most Relevant Research

We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.

The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.

Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.

8.8

Defence against cancer

Most Useful Review

Selenium is indispensable for maintaining health, based on its role in protecting against cancer through its antioxidant activity. A daily intake has notably increased my immune response and offers protection against harmful metals.

Cardiovascular Disease details

Selenium aids heart recovery post-MI

Based on 22 Researches

Selenium-loaded porous silica nanospheres improve cardiac repair after myocardial infarction by enhancing antioxidant activity and mitophagy.

Most Relevant Research

This study focused on how selenium-loaded porous silica nanospheres (Se@PSN) could help repair the heart following a myocardial infarction (MI). These tiny particles are designed to neutralize harmful molecules called reactive oxygen species, which play a significant role in heart damage during MI.

We found that Se@PSN not only reduces cellular damage but also promotes the production of protective antioxidant proteins. By enhancing mitochondrial function, these nanospheres could potentially preserve heart function after an MI, demonstrating promising results for future treatments.

9.5

Strengthens immunity

Most Useful Review

Excellent strength, price, and quality! It helps combat viral diseases and strengthens the immune system. Highly recommended!

Chronic Fatigue Syndrome details

Selenium effects on chronic fatigue

Based on 3 Researches

Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Green Tea on Chronic Fatigue Syndrome.

Most Relevant Research

We studied how selenium-polysaccharides (Se-TP) from green tea could improve chronic fatigue syndrome (CFS) in a rat model. Our experiments revealed that Se-TP significantly enhanced levels of certain substances related to fatigue, indicating improved overall condition. However, while the treatment showed promise in restoring some metabolic markers, the overall efficacy in CFS management remains to be fully affirmed. The changes observed were tied to metabolic pathways involved in steroid hormone biosynthesis and other critical processes.

8.3

Enhanced well-being

Most Useful Review

After tests revealed low levels of selenium and iodine, I began taking selenium. Within two weeks, my overall wellbeing improved significantly, and fatigue decreased. It also reduced heavy metal levels in my body, and I felt revitalised.

Cold Sores details

Effective against colds

I find this form of selenium very effective. At the first sign of a cold, I take it with zinc and higher doses of vitamins C and D, and by morning I feel completely well! It’s crucial to pair it with iodine as selenium helps with iodine absorption.

Flu details

It works! I drink selenium during flu season to support my immune system. After suffering from coronavirus over the summer and subsequently pneumonia, I now regularly take selenium and zinc. Fortunately, I haven't fallen ill again, even though many at work are currently experiencing colds with runny noses and sneezing.

Hashimoto details

Selenium effective in Hashimoto's treatment

Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis.

Most Relevant Research

We examined the impact of selenium supplements on thyroid autoantibody levels in patients with Hashimoto's thyroiditis.

In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.

However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.

This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.

8.8

Reduced antibodies

Most Useful Review

Great selenium supplement! I use this because I have Hashimoto's thyroiditis, and selenium aids in reducing thyroid antibodies. This supplement contains three forms of selenium, ensuring its effectiveness. It also includes vitamin E, enhancing selenium absorption, and the price on iHerb is fantastic!

Liver Disease details

Selenium nanoparticles reduce liver toxicity

Based on 29 Researches

Chitosan-encapsulated selenium nanoparticles alleviate CCl induced hepatotoxicity through synergistically modulating NF-κB and Nrf2 signaling pathways and regulating Bcl-2 and Caspase-3 expression: A comprehensive study with multiple regression analysis.

Most Relevant Research

We investigated how selenium nanoparticles (Se-NPs) and chitosan-encapsulated selenium nanoparticles (Se-CS-NPs) can mitigate liver toxicity induced by carbon tetrachloride (CCl) in rats. In our study, eighty rats were divided into eight groups, including placebo and control.

The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.

9.5

Supports eye health

Most Useful Review

I use selenium for treating endocrine ophthalmopathy, and currently, in Russia, there are no pure selenium products available. This selenium combines three forms, and I alternate it with another brand. Endocrinologists recommend its use for mild cases. After four months, I can attest to its effectiveness; my symptoms have significantly improved, including the regression of eye issues related to thyroid disease.

Pots details

Completely cleared stains

Working! I tested with peroxide and had numerous white spots. After taking this medicine, my follow-up test was pleasantly surprising—not a trace of the stains remained.

Arthritis details

Selenium and E are minerals and trace elements that can relieve joint pain in rheumatoid arthritis.

Asthma details

Selenium intake boosts lung function

Based on 8 Researches

The correlation between selenium intake and lung function in asthmatic people: a cross-sectional study.

Most Relevant Research

This study explored how selenium intake relates to lung function in people with asthma. We analyzed data from 4,541 participants in a national survey using various statistical methods. Our findings showed a positive connection between higher selenium intake and better lung function, particularly in forced vital capacity and forced expiratory volume. We noted that to potentially enhance respiratory health, asthma patients could benefit from consuming between 137.65 mcg and 200 mcg of selenium daily, while also being cautious of any adverse effects.

9.5

Regulates thyroid function

Most Useful Review

The selenium in this supplement serves as an antioxidant, reducing oxidative stress, and may help in cancer protection, boosting immunity, enhancing blood circulation, and reducing the likelihood of cardiovascular problems while easing asthma symptoms.

Brain Tumor details

Supports thyroid function

The best selenium! As part of the Super Selenium complex, it contains three forms of selenium along with vitamin E. Selenium helps maintain normal thyroid gland function and boosts immunity. It also enhances heart and brain functioning.

Leg Cramps details

Vitamin E alleviates leg cramps

Based on 3 Researches

Leg cramps (systremma0 and "restless legs" syndrome. Response to vitamin E (tocopherol).

Most Relevant Research

We investigated the impact of vitamin E on treating frequent and severe nocturnal leg cramps. Patients received 100 I.U. of d, alpha-tocopheryl acetate three times daily before meals.

Remarkably, nearly all participants reported prompt relief from their symptoms. This group included 24 patients with leg cramps and a couple with "restless legs" syndrome.

Given that nocturnal leg cramps can be distressing and treatments are often unsatisfactory, these findings are particularly noteworthy.

9.5

Prevents convulsions

Most Useful Review

I used to wake up with painful leg cramps, but after taking selenium, I've forgotten what those convulsions feel like. I will continue this for prevention purposes; it's truly made a difference for me.

Pelvic Pain details

Vitamin E reduces menstrual pain

Based on 17 Researches

A randomised controlled trial of vitamin E in the treatment of primary dysmenorrhoea.

Most Relevant Research

We investigated whether vitamin E could help with primary dysmenorrhea, a common cause of pelvic pain for young women. In our study, 278 girls aged 15-17 took either vitamin E or a placebo before and during their menstrual periods.

Results showed that those taking vitamin E experienced significantly less pain and shorter pain duration compared to the placebo group. There was also a notable reduction in menstrual blood loss. This suggests that vitamin E may be a beneficial option for managing menstrual discomfort.

9.5

Thyroid discomfort relief

Most Useful Review

I consistently alternate between different brands, and a dosage of 200 is perfect. Although it's advised not to take selenium constantly, I've noticed my eyes have returned to normal, and the heaviness, pain, and pressure in my thyroid at night have subsided.

Sleep Apnea details

Examined antioxidants in sleep apnea

The role of antioxidant vitamins and selenium in patients with obstructive sleep apnea.

Most Relevant Research

We examined the levels of selenium and key vitamins in patients suffering from obstructive sleep apnea (OSA) without additional health issues. Our study, involving 146 subjects split into different OSA severity levels, aimed to understand how these antioxidants might play a role in OSA's impact on health.

Interestingly, we found that higher concentrations of selenium and vitamin A appeared to bolster the body’s defense against OSA. Although our findings suggest potential benefits, it's important to note that antioxidants alone should not replace conventional treatments for OSA.

9.5

Enhanced energy levels

Most Useful Review

This complex is an effective dietary supplement for my age-related thyroid issues. It supports the thyroid gland, leading to healing and rejuvenation. I categorically abstain from hormones and rely on natural complexes. My sleep has normalised, which feels like a gift during menopause. The uncontrolled appetite has subsided, and I have noticed a significant improvement in my overall mood—both physical and mental. I am very satisfied and highly recommend it to older women.

Bone Pain details

This product was recommended on a thyroid forum. Although it's too early to determine its benefits, I believe I may have experienced some. A week ago, I suffered terrible pain from a fallen arch in my right foot. I took this supplement as this condition can relate to low thyroid function. After two days of wearing supportive shoes and taking selenium, the excruciating pain vanished! I was amazed to have NO pain at all just two days later. I hope the selenium played a part in this swift recovery.

Chronic Cough details

Selenium with vitamin E works wonderfully when combined. I took it to bolster my immune system, tackle male and female infertility, and combat chronic fatigue. My husband and I are pleased with the outcome; we feel more energetic and have experienced no colds this past year. I highly recommend purchasing it!

Diabetes details

Selenium aids gestational diabetes management

Based on 21 Researches

Selenium Supplementation and Gestational Diabetes: A Randomised Controlled Trial.

Most Relevant Research

We explored whether selenium supplementation could improve blood glucose levels in pregnant women with gestational diabetes. In this randomized controlled trial conducted at an Istanbul university, women diagnosed with gestational diabetes received either diet alone or diet plus 200 µg of selenium daily for four weeks.

Findings showed that pregnant women had lower selenium levels compared to healthy counterparts. Those taking selenium experienced a more significant decrease in blood sugar levels than those on diet alone, indicating a beneficial effect of selenium on managing gestational diabetes.

9.5

Effective treatment

Most Useful Review

Excellent! This complex preparation is of suitable dosage and provides good results. I take it for diabetes and highly recommend it.

Psoriasis details

Perfectly! This supplement helps me heal psoriasis spots on my skin more rapidly. Personally, I noticed the effect within a week; the itching diminished and the condition of my spots improved. Additionally, I've felt much more cheerful overall. I plan to purchase it again.

Stroke details

Excellent quality; it offers permanent protection for all our body’s cells against the detrimental effects of free radicals. This helps prevent premature aging of tissues, loss of hair, teeth, and dryness of the skin. Selenium reduces the risks of poisoning, heart and vascular issues, and lowers the likelihood of stroke and Alzheimer’s disease.

Weight Loss details

Positive dynamics observed

I have hypothyroidism and took this jar as I learned selenium helps regulate the thyroid gland while on a low-dose hormonal therapy. After a month, I noticed some changes; the main issue being excess weight and fluid retention. My doctor advised I lose weight to avoid increasing my hormone dosage, and despite training, it wasn’t effective. I also bought green tea extract for puffiness. I can say there’s positive progress; my weight is normalising, and my jeans fit more comfortably. Though the puffiness is still stubborn, this isn’t a weight loss product; it's helping my body return to normal.

Yeast Infection details

Supports yeast prevention

Great Complex Selena! Life Extension selenium comprises three organic forms: selenomethionine, selenite, and selenocysteine, supplemented with vitamin E to enhance its action. This selenium complex is vital for individuals prone to candidiasis. The small capsules have a distinctive smell, but as a medicine, it is tolerable for health. Selenium is an essential antioxidant, aiding the removal of free radicals and offering protection against cancer cells. It is indispensable for treating and preventing thyroid hypofunction and thyroiditis. I always consult a doctor when taking any medicines or vitamins. I take one capsule every evening after meals. I am confident this complex benefits my body! I plan to continue this annually in spring and autumn. I wish everyone good health!

Autoimmune Disorder details

Selenium aids Graves' orbitopathy treatment

Questionable

Based on 17 Researches

The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.

Most Relevant Research

We explored how selenium supplementation might help individuals suffering from Graves' orbitopathy, an autoimmune disorder linked to thyroid dysfunction. Our approach involved a systematic review and meta-analysis that assessed results from four randomized controlled trials.

The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.

We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.

Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.

9.5

Improved skin health

Most Useful Review

Great supplement! I’m currently on my second jar, as advised by a nutritionist based on test results. After a short time, she observed that my skin became incredibly smooth, with cracks and dryness disappearing. My chronic runny nose and congestion have also resolved, leading to an overall improvement in my condition. Selenium is advised to take in courses for those with thyroid issues. I will order more!

Breast Cancer details

Selenium compounds may fight breast cancer

Based on 18 Researches

Di- and Triselenoesters-Promising Drug Candidates for the Future Therapy of Triple-Negative Breast Cancer.

Most Relevant Research

We set out to explore the effects of selenium-containing compounds on breast cancer cells, particularly focusing on their potential as treatments. Our research involved testing several novel selenoesters on two breast cancer cell lines, MCF-7 and MDA-MB-231, to understand how these compounds can impact cell growth and survival.

What we found was quite promising. The selenoesters showed significant cytotoxic effects, meaning they can kill cancer cells effectively, even at very low doses. We observed that these compounds triggered important processes that lead to cell death, specifically by activating pathways that make cells undergo apoptosis, or programmed cell death.

The mechanisms at play include both the extrinsic and intrinsic apoptosis pathways, which means they are working from multiple angles to combat cancer. Additionally, these compounds also activate autophagy, a process that helps clear out damaged cells and contributes to the overall effectiveness of the treatment.

In summary, our findings suggest that these selenium-based compounds could be valuable candidates for future breast cancer therapies, worth considering in the ongoing fight against this disease.

9.5

Effective skin remedy

Most Useful Review

This brand and dosage are fantastic! After a period of late nights and sleep deprivation, I had a flare-up of skin issues. Upon taking a blend of vitamins and this selenium supplement, I noticed significant improvement. The swollen, itchy skin reduced drastically within two days. It's far more effective than Western antiviral medicines! Now, it's a staple in my home for daily intake. If you have hepatitis B, I recommend combining selenium with natural vitamin E and silymarin to protect your liver and lower the risk of liver cancer.

Food Poisoning details

Effect of SeNPs on ZEA toxicity

Based on 4 Researches

Prophylactic supplementation with selenium nanoparticles protects against foodborne toxin zearalenone-induced intestinal barrier dysfunction.

Most Relevant Research

We explored the protective effects of selenium nanoparticles (SeNPs) against the harmful impacts of zearalenone (ZEA), a toxin from grains that can disrupt gut health. In a controlled setting, we observed that ZEA damages intestinal cells, leading to inflammation and increased permeability.

Our findings showed that SeNPs can counteract this damage by enhancing antioxidant activity and improving gut microbiota balance. Despite these promising results, it’s crucial to note that the effectiveness of SeNPs in humans still requires further investigation.

9.5

Supports thyroid health

Most Useful Review

This supplement is effective for supporting the endocrine system. Selenium is crucial for our health, and due to dietary insufficiencies, I find it necessary. This product aids in the absorption of iodine, which is vital for thyroid function. I take it daily as a prevention against hyperthyroidism and recommend it to those with similar concerns.

Hair Loss details

Selenium aids hair loss in PCOS

Based on 2 Researches

Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome.

Most Relevant Research

We conducted a randomized double-blind, placebo-controlled trial to explore how selenium supplementation may influence hair loss among women with polycystic ovary syndrome (PCOS). In the study, 64 women aged 18-40 received either 200 μg of selenium daily or a placebo for eight weeks.

After the treatment period, we noticed a significant improvement in hair-related issues for those taking selenium. Specifically, alopecia rates dropped from 40.6% in the selenium group to just 9.4% in the placebo group, showing a strong positive effect of the supplement on hair loss. Acne also improved, with a reduction from 46.9% to 12.5%.

Furthermore, women who took selenium supplements exhibited decreased levels of dehydroepiandrosterone (DHEA), hirsutism, and markers of inflammation and oxidative stress. However, it’s important to note that selenium did not show significant effects on some hormonal profiles and other biomarkers. Overall, our findings suggest that selenium can be beneficial for women with PCOS, particularly regarding hair loss and related symptoms.

9.5

Improved health

Most Useful Review

I was prescribed this for hyperthyroidism. Surprisingly, my health improved; my hair loss stopped, and I felt more energetic. My friend also found it useful for hair loss. The doctor recommended taking it regularly with meals, as it has a positive effect on thyroid function.

Heart Attack details

Selenium nanoparticles for heart health

Based on 29 Researches

A Self-Sustaining Antioxidant Strategy for Effective Treatment of Myocardial Infarction.

Most Relevant Research

We examined the role of selenium in treating myocardial infarction (MI), a major cause of death worldwide that can lead to serious heart problems. The study focused on how this antioxidant works across different phases of a heart attack, where harmful reactive oxygen species (ROS) play a significant role in worsening the condition.

Our findings highlighted a new approach using selenium-embedded nanoparticles, which are specially designed to act as antioxidants at various stages of MI. This innovative method allows for selective ROS elimination when it's most needed, leading to impressive recovery outcomes for the heart.

Throughout the research, it became clear that these nanoparticles help protect vital functions in heart cells by reducing cell death, inflammation, and scar tissue, while also encouraging new blood vessel growth. Overall, this self-sustaining antioxidant strategy shows great potential, not just for treating heart attacks but also inspiring therapies for other ischemic conditions.

9.5

Improved energy levels

Most Useful Review

The complex is effective! I began taking it on the advice of a nutritionist to restore my thyroid function, addressing fatigue, muscle weakness, and heart issues. Almost immediately, I felt better; my energy increased, hair loss decreased, and my heartbeat was more stable. I recommend this essential vitamin for optimal body performance. Please like if you find this helpful.

High Cholesterol details

Selenium supports cholesterol management

Based on 32 Researches

Modulation of hypercholesterolemia-induced alterations in apolipoprotein B and HMG-CoA reductase expression by selenium supplementation.

Most Relevant Research

We investigated how selenium supplementation affects cholesterol levels and the associated molecular changes. Using Sprague-Dawley male rats, we fed them diets supplemented with selenium alongside high cholesterol for three months.

The results showed that while apolipoprotein B levels rose with the cholesterol diet, supplementing with 1 ppm of selenium significantly reduced these levels. Additionally, the expression of HMG-CoA reductase also decreased with selenium supplementation.

Overall, our findings suggest that selenium could offer a supportive role in managing lipid metabolism and high cholesterol.

8.8

Reduced hair loss

Most Useful Review

The ingredients are balanced, the quantity is appropriate, and the packaging is good. This product helped me avoid thyroid medication. Although the taste and smell are not pleasant, I've experienced no symptoms and repeat my order, having found hair loss reduced simply by using this effective formula, albeit at an expensive price.

Hypertension details

Positive health trend

The selenium from the reputable American company Life Extension has impressed me. They have been dedicated to health-related research since 1980. Their products, including this selenium complex, appeal to me because of their scientific basis. I trust their formulation as it contains three forms of selenium and vitamin E to enhance absorption. At 55, with hypertension and other conditions, my endocrinologist recommended selenium. Since starting this supplement, I've noticed improvements in my thyroid hormone tests, lowered blood pressure, and a steadier heart rate. Furthermore, I also take vitamin D3, Omega, and coenzyme Q10.

Insomnia details

Excellent implementation after COVID. I began using this on my doctor's recommendation after my family fell ill with COVID. Personally, I experienced lingering insomnia, interrupted sleep, and constant irritability. After taking this selenium product for two months, my sleep has improved. While irritability hasn't completely vanished, my emotional state has levelled off to some extent. If anyone has advice on rehabilitating skin after COVID, please share your insights. Periodic rashes and a poor skin tone have been concerning.

Lung Cancer details

Selenium compound inhibits lung tumors

A novel selenium nanocomposite modified by AANL inhibits tumor growth by upregulating CLK2 in lung cancer.

Most Relevant Research

We explored the effectiveness of a novel selenium nanocomposite, AANL-SeNPs, in treating lung cancer. This innovative compound, created from a natural ingredient, demonstrated significant inhibition of lung cancer cell growth in various cell lines, showing up to a 67% reduction in viability.

Furthermore, AANL-SeNPs slowed tumor growth in live models and appeared safe for normal cells. While promising, our findings indicate that although AANL-SeNPs upregulate the protein CLK2 and can enhance therapeutic response, further studies are needed to fully understand its potential.

9.5

Anti-cancer benefits

Most Useful Review

The king of anti-cancer must be consumed; I've already had three bottles.

Prostate Cancer details

Selenium nanoparticles show promise

Based on 17 Researches

Intracellular Fate of Sub-Toxic Concentration of Functionalized Selenium Nanoparticles in Aggressive Prostate Cancer Cells.

Most Relevant Research

We explored the impact of selenium nanoparticles, known for their potential anti-cancer properties, on aggressive prostate cancer cells, specifically the PC-3 line. The study focused on understanding how sub-toxic levels of selenium functionalized nanoparticles affect cell proliferation and their intracellular behavior.

By utilizing advanced imaging techniques and careful cryopreparation, we aimed to preserve the integrity of the cancer cells while analyzing the distribution of these nanoparticles within them. Our findings revealed that nanoparticles coated with bovine serum albumin (BSA) reduced the migration capability of the cancer cells more effectively than those coated with chitosan.

This difference may be attributed to the BSA coating's ability to prevent harmful interactions with the cell membranes, which in turn limits the generation of reactive oxygen species that can damage cells. Most intriguingly, we observed that these selenium nanoparticles localized in both the mitochondria and lysosome-related organelles within the cells. The presence of nanoparticles in the mitochondria might explain the significant reduction in the PC-3 cells' ability to proliferate.

Overall, our investigation highlights the promising role selenium nanoparticles can play in cancer treatment strategies, providing valuable insights for further research into their cytotoxic mechanisms against prostate cancer.

9.5

Overall health

Most Useful Review

This excellent supplement prevents cancer, boosts immunity, and improves the circulatory system. Selenium protects against free radicals and is essential for thyroid hormone production.

Acne details

Questionable