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Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
125 mcg
625%
Vitamin K activity from:Vitamin K1 (as phytonadione)Vitamin K2 (as menaquinone-4)Vitamin K2 (as trans menaquinone-7)
2,100 mcg1,000 mcg1,000 mcg100 mcg
1,750%
Iodine [from Sea-Iodine™ Complex Blend (organic kelp and bladderwrack extracts, potassium iodide)]
1,000 mcg
667%
The product is found useful for the following medical conditions
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 59 Reviews
9
9.5
Bone health support
Most Useful Review
An excellent complex of vitamins, including D3, K2, and iodine, which promotes cognitive and bone health, as well as immune function. Vitamin K maintains calcium balance in the body, essential for cardiovascular health and bone density. Iodine is vital for thyroid hormone production. Consulting with a doctor before use is advisable.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5
USERS' SCORE
Excellent
Based on 22 Reviews
9
2
Vitamin D3 ineffective for CFS
Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome--a randomised controlled trial.
Most Relevant Research
We conducted a thorough investigation into whether high-dose intermittent vitamin D3 could alleviate symptoms of chronic fatigue syndrome (CFS) and improve vascular health. This double-blind, randomized placebo-controlled trial involved patients meeting established criteria for CFS. Participants received either 100,000 units of vitamin D3 or a placebo every two months for six months.
Over the course of the study, we measured key outcomes such as arterial stiffness, blood pressure, cholesterol levels, and fatigue levels through various tests. Surprisingly, our findings showed that vitamin D3 treatment did not lead to any significant improvements in these areas. We observed only a slight increase in vitamin D levels in the treatment group, but this did not translate into better vascular health or reduced fatigue.
In conclusion, we honestly found that high-dose vitamin D3 did not offer any notable benefits for patients struggling with chronic fatigue syndrome. This study highlights the complexities of treating CFS and suggests that vitamin D3 may not be the solution some had hoped for.
Over the course of the study, we measured key outcomes such as arterial stiffness, blood pressure, cholesterol levels, and fatigue levels through various tests. Surprisingly, our findings showed that vitamin D3 treatment did not lead to any significant improvements in these areas. We observed only a slight increase in vitamin D levels in the treatment group, but this did not translate into better vascular health or reduced fatigue.
In conclusion, we honestly found that high-dose vitamin D3 did not offer any notable benefits for patients struggling with chronic fatigue syndrome. This study highlights the complexities of treating CFS and suggests that vitamin D3 may not be the solution some had hoped for.
9.5
Improved energy levels
Most Useful Review
I've been taking this vitamin for 3 months and can see the difference. My quality of life has improved immensely, with no more fatigue or lack of motivation to get out of bed. I feel more energised, can concentrate better, and my mood has significantly improved. I highly recommend it.
Blood Clot details
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.1
USERS' SCORE
Good
Based on 14 Reviews
8.8
8
Vitamin D may influence blood clotting
Relationship between vitamin D deficiency and thrombus load in patients with ST-elevation myocardial infarction.
Most Relevant Research
We explored the connection between vitamin D levels and coronary thrombus load in patients who experienced ST-elevation myocardial infarction (STEMI). The study included 77 patients where we measured serum vitamin D levels, thrombus degree, and other relevant factors.
Our findings revealed that a concerning 79.22% of participants showed vitamin D deficiency, with those having milder thrombus loads possessing significantly higher vitamin D levels compared to those with severe thrombus loads. Moreover, as we assessed the severity of coronary artery condition, we noted that patients with higher thrombus burden also had markedly greater scores of atherosclerosis.
Importantly, we found clear negative correlations between vitamin D levels and measures of thrombus burden. Lower vitamin D levels aligned with higher TIMI frame counts—meaning more extensive vascular obstruction—suggesting that vitamin D might play a role in blood clot formation.
Overall, we determined that low 25(OH)D3 levels could be an independent predictor of high coronary artery thrombus load in STEMI patients. These findings highlight the potential significance of monitoring and perhaps addressing vitamin D levels in this vulnerable group.
Our findings revealed that a concerning 79.22% of participants showed vitamin D deficiency, with those having milder thrombus loads possessing significantly higher vitamin D levels compared to those with severe thrombus loads. Moreover, as we assessed the severity of coronary artery condition, we noted that patients with higher thrombus burden also had markedly greater scores of atherosclerosis.
Importantly, we found clear negative correlations between vitamin D levels and measures of thrombus burden. Lower vitamin D levels aligned with higher TIMI frame counts—meaning more extensive vascular obstruction—suggesting that vitamin D might play a role in blood clot formation.
Overall, we determined that low 25(OH)D3 levels could be an independent predictor of high coronary artery thrombus load in STEMI patients. These findings highlight the potential significance of monitoring and perhaps addressing vitamin D levels in this vulnerable group.
9.5
Good results noted
Most Useful Review
I first ordered this over a year ago for my child. The D levels rose from 24 to 58 in just three months. I am very pleased with the results and have ordered it again.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Good
Based on 32 Reviews
8.7
9
Vitamin D3 modulates autoimmune response
Vitamin D3 attenuates autoimmune thyroiditis by regulating Th17/Treg cell differentiation via YAP/JAK1/STAT1 axis.
Most Relevant Research
We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
9.5
Significant improvement
Most Useful Review
I purchased this for my mother, and it’s been remarkable. The combination within one capsule is robust, boosting her vitamin D levels significantly from 26 ng/ml to 78 ng/ml. I will definitely order it again.
Common Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.4
USERS' SCORE
Good
Based on 22 Reviews
8.7
9
Iodine reduces rhinovirus infections
Interruption of experimental rhinovirus transmission.
Most Relevant Research
We explored the effectiveness of 2% aqueous iodine in preventing infections caused by rhinoviruses, the culprits behind the common cold. In a controlled setting, volunteers had their fingers treated with iodine before being exposed to the virus. Remarkably, none of the eight participants who received the iodine treatment became infected immediately afterwards. In contrast, all of the seven volunteers treated with a placebo did get infected.
We also noticed that when exposure occurred two hours after iodine application, only one out of ten volunteers fell victim to the virus, whereas six out of ten in the placebo group became ill. The difference was notable, though not quite statistically significant. Additionally, tests showed virus presence in only 11% of hand washes from those who used iodine, compared to 41% from the placebo group, suggesting that iodine may substantially reduce virus contamination on hands.
Overall, these findings indicate that using iodine could be an effective strategy in preventing common cold infections, especially right after treatment. It seems that applying iodine to our hands may serve as a protective measure against rhinovirus, significantly reducing the chances of getting sick.
We also noticed that when exposure occurred two hours after iodine application, only one out of ten volunteers fell victim to the virus, whereas six out of ten in the placebo group became ill. The difference was notable, though not quite statistically significant. Additionally, tests showed virus presence in only 11% of hand washes from those who used iodine, compared to 41% from the placebo group, suggesting that iodine may substantially reduce virus contamination on hands.
Overall, these findings indicate that using iodine could be an effective strategy in preventing common cold infections, especially right after treatment. It seems that applying iodine to our hands may serve as a protective measure against rhinovirus, significantly reducing the chances of getting sick.
8.8
Consistent health improvement
Most Useful Review
Prior to this supplement, I frequently suffered from the common cold and sore throats. After starting on Vitamins D and K for immune support, I have not had any signs of colds or flu for over 18 months, despite family illness.
Ear Infection details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.7
9.5
Strengthened immunity
Most Useful Review
Vitamin D is our essential assistant in first aid, particularly during epidemics. We trust the manufacturer, and taking it has undoubtedly bolstered my immunity—no infections were encountered around ill individuals.
Lung Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.7
USERS' SCORE
Good
Based on 7 Reviews
8.7
9
Vitamin D3 inhibits lung cancer growth
Inhibition of lung cancer by vitamin D depends on downregulation of histidine-rich calcium-binding protein.
Most Relevant Research
We conducted a study to understand how vitamin D3 influences lung cancer, particularly focusing on a protein known as histidine-rich calcium-binding protein (HRC). Our research explored whether vitamin D3 could help lower HRC levels, given its crucial role in calcium balance, which is significant in cancer development.
We measured the expression of HRC and the vitamin D receptor (VDR) in lung cancer tissues compared to normal and adjacent non-cancerous tissues. Using various lab techniques, we assessed how vitamin D3 affects lung cancer cells, including their growth, spread, and ability to undergo programmed cell death, known as apoptosis.
Our findings revealed that vitamin D3 does inhibit the expression of HRC, which in turn decreased the migration and proliferation of lung cancer cells. Additionally, we noted an increase in the number of cells undergoing apoptosis in response to vitamin D3 treatment. In our animal model, mice treated with a vitamin D3 formulation exhibited smaller tumors and fewer cancerous cells than those treated with a combination of vitamin D3 and HRC.
Overall, our study indicates that vitamin D3 plays a protective role against lung cancer by downregulating HRC, thus slowing tumor growth and promoting cancer cell death.
We measured the expression of HRC and the vitamin D receptor (VDR) in lung cancer tissues compared to normal and adjacent non-cancerous tissues. Using various lab techniques, we assessed how vitamin D3 affects lung cancer cells, including their growth, spread, and ability to undergo programmed cell death, known as apoptosis.
Our findings revealed that vitamin D3 does inhibit the expression of HRC, which in turn decreased the migration and proliferation of lung cancer cells. Additionally, we noted an increase in the number of cells undergoing apoptosis in response to vitamin D3 treatment. In our animal model, mice treated with a vitamin D3 formulation exhibited smaller tumors and fewer cancerous cells than those treated with a combination of vitamin D3 and HRC.
Overall, our study indicates that vitamin D3 plays a protective role against lung cancer by downregulating HRC, thus slowing tumor growth and promoting cancer cell death.
9.5
Survived cancer
Most Useful Review
Vitamin D helped me survive Stage 4 metastatic melanoma cancer. I’ve been taking this product for over nine years, and I owe my survival in part to raising my vitamin D levels to 180. At 75 years old, I appreciate the strength it has given me, as shown in the photos of before and after.
Osteoporosis details
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.4
USERS' SCORE
Good
Based on 17 Reviews
8.7
9
Vitamin D derivatives enhance bone health
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities.
Most Relevant Research
We looked into the potential effects of vitamin D3, particularly its derivatives, on osteoporosis. Recent research highlights how modifications to the A-ring of 1α,25-dihydroxyvitamin D can enhance its binding to the vitamin D receptor. This change not only boosts the vitamin's effectiveness but also helps it resist breakdown in the body, making it stay active for longer periods.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
9.5
Visible changes
Most Useful Review
My son has osteoporosis and blood clotting issues. Within days of taking this supplement, bleeding decreased significantly, and joint pain improved, reducing the need for painkillers. The small capsules are easy to take, and the price is very reasonable for such quick results.
Cardiovascular Disease details
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.5
USERS' SCORE
Good
Based on 17 Reviews
8.6
8
Vitamin D improves heart disease factors
The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.
Most Relevant Research
We conducted a double-blind, randomized clinical trial to see how treating vitamin D deficiency could influence heart health, particularly in patients with ischemic heart disease (IHD). In our study, 44 IHD patients aged 40 to 65 were treated with either vitamin D or a placebo to assess changes in their lipid profiles and C-reactive protein (CRP) levels.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
9.5
Effective vitamin combo
Most Useful Review
Checked, it works. The combination of vitamins D and K is excellent. I feel superb after taking it with omega and vitamin C. During a recent illness, I found taking a loading dose along with vitamin C and zinc crucial; I experienced minimal symptoms. This product is just what I needed, and I appreciate its efficacy, so I encourage others to try it for their cardiovascular health.
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.6
10
Cramps eliminated
Most Useful Review
It works! The leg cramps are gone at last! I was sceptical, initially used it just to test, but I have no regrets! I will continue taking more.
Sleep Apnea details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
USERS' SCORE
Good
Based on 12 Reviews
8.4
9
Vitamin D3 improves mild sleep apnea
The effects of vitamin D supplemantation on prognosis in patients with mild obstructive sleep apnea syndrome.
Most Relevant Research
We set out to evaluate what effect vitamin D3 supplementation might have on patients suffering from mild obstructive sleep apnea syndrome (OSAS). In this study, 19 adult men who were diagnosed with mild OSAS and had low vitamin D levels participated over an 8-week period. Each week, they took a sizable dose of 50,000 IU of vitamin D3 while undergoing various health assessments. We measured important factors like blood glucose, lipid profiles, and inflammation markers, along with repeated sleep monitoring through polysomnography.
By the end of the study, we observed a significant increase in participants' vitamin D levels, which jumped from an average of 19.5 to 41.8 ng/mL—an indication that the supplementation was effective. Along with this rise in vitamin D, we also noted improvements in fasting blood glucose and total cholesterol levels, as well as a decrease in key inflammation markers. Most encouragingly, the frequency of obstructive apneas and other related sleep disturbances significantly decreased.
Based on these findings, it seems that vitamin D supplementation can play a beneficial role in improving the prognosis for those with mild OSAS. It's exciting to consider how something as simple as a vitamin could lead to better sleep health for individuals struggling with sleep apnea.
By the end of the study, we observed a significant increase in participants' vitamin D levels, which jumped from an average of 19.5 to 41.8 ng/mL—an indication that the supplementation was effective. Along with this rise in vitamin D, we also noted improvements in fasting blood glucose and total cholesterol levels, as well as a decrease in key inflammation markers. Most encouragingly, the frequency of obstructive apneas and other related sleep disturbances significantly decreased.
Based on these findings, it seems that vitamin D supplementation can play a beneficial role in improving the prognosis for those with mild OSAS. It's exciting to consider how something as simple as a vitamin could lead to better sleep health for individuals struggling with sleep apnea.
9.5
Better sleep observed
Most Useful Review
I have been taking one capsule before bed for about a week, and now I can sleep soundly until morning. The capsule size is small and easy to swallow.
Heart Attack details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.3
USERS' SCORE
Good
Based on 3 Reviews
8.2
9
Calcitriol aids heart recovery
Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction.
Most Relevant Research
We examined the impact of calcitriol, the active form of vitamin D, on heart attack recovery using a mouse model of myocardial infarction (MI). In our study, we treated mice that had suffered a MI with calcitriol and observed promising results.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
8.8
Heart no longer pains
Most Useful Review
I am highly satisfied with the vitamin D product in capsule form. Its combination with vitamin K effectively delivers benefits where needed most. Over nine months, my heart pain subsided; I previously used Panangin. The added iodine is relevant for my region. Overall, this product suits me well, and delivery was prompt.
Liver Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8
9
Vitamin D3 aids liver health
Effects of vitamin D supplementation on the glycaemic indices, lipid profile and liver function tests in patients with cirrhosis: a double-blind randomised controlled trial.
Most Relevant Research
We aimed to explore how vitamin D3 supplementation affects liver disease, specifically in patients with cirrhosis. In a thorough double-blind, randomized controlled trial involving 60 participants, we offered patients either a weekly dose of 50,000 IU of vitamin D or a placebo for 12 weeks. Our goal was to assess various health indicators, including serum vitamin D levels, blood glucose measures, and liver function tests.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
6.3
Vitamin provision
Most Useful Review
A good product that includes vitamin K, essential for liver health and overall bodily wellness. I believe it is crucial to provide all necessary vitamins for optimal health. I recommend lowering the price for wider accessibility.
Hyperthyroidism details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.8
9.5
Irreplaceable for hyperthyroidism
Most Useful Review
Good day! Perfect! I take it as prescribed by my doctor. This supplement is indispensable in managing my hyperthyroidism!
