Life Extension N-Acetyl L-Cysteine

We explored how N-acetylcysteine (NAC), a common mucolytic agent, plays a role in treating bronchitis associated with chronic obstructive pulmonary disease (COPD). This study focused on the treatable traits (TT) strategy, which aims to identify and manage specific traits of COPD that are clinically significant and manageable.

Our findings indicate that NAC is particularly valuable for patients experiencing a frequent productive cough, a common trait of bronchitis in COPD. Not only does it help reduce mucus buildup, but it also appears to have benefits for reducing airway inflammation and limitations in airflow.

Interestingly, the research highlights that NAC’s antioxidant and anti-inflammatory properties can support various symptoms linked to bronchitis. By adopting the TT strategy, including NAC in the treatment plan, we observed improvements in lung function and overall quality of life for patients, while minimizing unnecessary medication.

Thus, incorporating NAC into bronchitis management within the framework of personalized medicine shows promising potential to help patients manage their symptoms better and enhance their daily lives.

9.5

Effective bronchitis treatment

Most Useful Review

I was initially sceptical about the quality of Life Extension N-Acetyl-L-Cysteine (NAC) due to its lower price. However, I have found it very effective for treating bronchitis. Whenever I begin to cough or develop a cold, I start taking NAC, and it often prevents the bronchitis from worsening. It worked well for my latest cold, and I intend to keep using this brand because it’s effective and reasonably priced.

The precision medicine strategy to treat COPD pulmonary traits in clinical practice: The role of N-acetylcysteine.

Most Relevant Research

We examined the role of N-acetylcysteine (NAC) in treating cough, particularly among patients with Chronic Obstructive Pulmonary Disease (COPD). This treatment approach falls under the broader framework of the treatable traits strategy, which focuses on identifying and managing specific symptoms that significantly impact patients' lives.

Our findings highlighted NAC's well-established effectiveness as a mucolytic agent, meaning it helps break down mucus in the airways, which can alleviate persistent cough. However, we observed that NAC does not just target coughing alone; it also may have broader benefits for various clinical traits associated with COPD, such as airflow limitation and lung inflammation.

Nevertheless, the isolated effects of NAC strictly on cough treatment can be hard to discern due to these overlapping factors. In some cases, NAC has shown promise in improving symptoms and overall quality of life for COPD patients, suggesting it could be an important component of a personalized treatment plan.

Overall, NAC may not only target cough effectively but also plays a role in managing other serious symptoms of COPD, which makes it a valuable option for those seeking relief from this challenging condition.

9.5

Cough relief noted

Most Useful Review

Cough, cough, cough. Having asthma, a cold produces a nonproductive cough that lingers. When I remember to take N-Acetyl L-Cycteine, it breaks the cough up in a couple of days. Life Extension is a wonderful lab, and I've loved their products even during my years as a member. While I can't afford membership anymore, it’s good these products are now available on Amazon!

Flu details

SCIENTIFIC SCORE

Likely Very Effective

NAC shows promise for liver injury

Utility of N-acetylcysteine in Non-Acetaminophen-Induced Liver Injury Secondary to Influenza A Infection.

Most Relevant Research

We observed a fascinating case involving the use of N-acetylcysteine (NAC) to treat a young female patient who experienced acute liver injury during an influenza A infection. This situation raised a compelling question: Could NAC, typically known for addressing liver damage from acetaminophen, also provide benefits in other contexts?

Our findings highlighted that NAC is being explored for its potential effects on liver health during viral infections like influenza A. This is particularly intriguing given that the patient was facing impending liver failure, a serious complication often associated with such viral illnesses. By utilizing intravenous NAC, the patient showed a positive response.

Although the specific details of the study's methodology, such as control groups or blinding, were not provided, the outcome suggests promising effects of NAC in treating liver injury linked to viral infections. This case may pave the way for further research into NAC’s effectiveness for flu-related liver complications.

9.5

Quick cold relief

Most Useful Review

I bought this supplement to prepare for the cold and flu season and resorted to it sooner than expected when I caught my husband's cold. On 1/31, I started feeling ill and by the next day had congested sinuses and chest issues. I began taking a 600mg capsule twice daily, and by 2/5, I was back to work, feeling much better! Normally, colds linger, causing upper respiratory infections, but this product helped me recover quickly without needing antibiotics. This is a record for me!

Asthma details

Improved breathing capacity

Most Useful Review

If you have asthma, COPD, chronic bronchitis, or begin to feel a cold affecting your chest, take it! I’ve struggled with chronic allergies leading to chest problems. Since taking two a day, I could blow up pool floats easily for the first time in years! I know it was N-Acetyl Cysteine that made the difference. I highly recommend it for anyone with breathing difficulties!

Blood Clot details

I read that taking NAC is highly recommended nowadays as it combats oxidative stress and blood clotting, observed in many COVID-19 patients. I purchased this product and am highly satisfied. I take it daily and feel fantastic. I favour this brand for its absence of unnecessary ingredients, particularly avoiding magnesium stearate.

Chest Pain details

Chest sensitivity relief

Most Useful Review

My chest sensitivity and increased phlegm have been greatly relieved, thanks to my brother's recommendation of this product.

Chronic Fatigue Syndrome details

Boosted energy levels

Most Useful Review

I am recovering from an iron and copper deficiency that went undiagnosed for quite some time. After building my stores of these nutrients, NAC gave me an energy boost as well. I believe it is healing my cells from the years of stress associated with insufficient copper and iron. I highly recommend it for anyone as research shows many benefits of NAC.

Liver Disease details

NAC is essential in any medicine cabinet, particularly during a pandemic. Besides helping to expel mucus, it positively impacts the liver, promoting detoxification and glutathione production. I have tried NAC from various brands, and I highly commend this one from Life Extension.

Rash details

Rash completely healed

Most Useful Review

I have been drinking for many years. The primary reason I started taking it was due to a rash on my palm. All of the rashes have healed. I'm nearly 40, yet I have hardly any grey hair.

Sinusitis details

NAC's role in sinusitis unclear

[Postviral rhinosinusitis, focus on pathogenetic therapy].

Most Relevant Research

We examined how n-acetyl-l-cysteine (NAC) might impact those suffering from sinusitis, especially following a viral infection. This condition, known as post-viral rhinosinusitis, can be tricky due to overlapping symptoms with bacterial sinusitis, making diagnosis challenging.

In our review of current literature, we found that while NAC is included in combined treatments for sinusitis, determining its standalone effectiveness is complex. The treatment typically involves other components as well, notably a vasoconstrictor, which complicates our ability to attribute success to NAC alone.

Our analysis led us to conclude that despite the potential benefits of using NAC for sinusitis due to its mucolytic properties, the isolated benefits remain unclear. More targeted research is necessary to truly understand the role of this compound in managing sinusitis effectively.

9.5

Effective for inflammation

Most Useful Review

Life Extension N-Acetyl-L-Cysteine is excellent without unnecessary fillers. NAC has impressive antioxidant and anti-inflammatory properties, aiding those with respiratory diseases and sinusitis. It can help reduce bacterial infections, and I experienced no side effects. This is a quality product.

Urinary Tract Infection details

Regular cycles achieved

Most Useful Review

I’ve been taking NAC for years, and it has regulated my cycle to 28 days consistently and energised me. A brief break made me feel lethargic, but resuming NAC restored my vitality and cleared the mucus in my throat. I trust this brand and am satisfied with its quality.

Cold details

SCIENTIFIC SCORE

Likely Very Effective

N-acetylcysteine protects cold platelets

The effect of modulating platelet reactive oxygen species by the addition of antioxidants to prevent clearance of cold-stored platelets.

Most Relevant Research

We explored the impact of N-acetylcysteine, an antioxidant, on the preservation of cold-stored platelets. The study focused on understanding how this treatment might reduce the harmful effects caused by reactive oxygen species (ROS) generated during cold storage.

Platelet concentrates were categorized into three groups: those stored at room temperature, those kept cold, and those cold-stored with added N-acetylcysteine at varying concentrations. After five days of storage, we measured ROS production, lipid peroxidation, platelet activation, and other quality indicators.

Our findings highlighted that N-acetylcysteine effectively diminished the production of ROS, thus protecting the cold-stored platelets from damage and premature clearance by the immune system in both lab settings and live models. Importantly, using the right amount of N-acetylcysteine significantly improved the survival of these platelets in circulation.

Overall, this study sheds light on the potential benefits of incorporating antioxidants in platelet storage practices to enhance their functionality and longevity.

9.5

Speeds up recovery

Most Useful Review

Great for shortening a cold! I bought it in anticipation of the cold and flu season, needing it sooner than expected after catching my husband's cold. I started feeling sick on the 31st and took a 600mg capsule twice daily. By the 5th, I was back at work, feeling much better! This time, I expelled nasty mucus easily and avoided a prolonged upper respiratory infection. I consider this a record recovery time for me!

Allergies details

Sinus infections reduced

Most Useful Review

I take one tablet daily to manage allergies during spring and autumn, and it has also significantly reduced my sinus infections in winter. Since starting NAC, I rarely get sinus infections, whereas I used to suffer from three each winter.

Cardiovascular Disease details

I bought NAC for a friend to help ease the course of COVID. He has been taking it as part of a general protocol for several days and says that he feels better with it. He takes one capsule every 12 hours, either before or separately from meals.

Pelvic Pain details

My wife can confirm the effectiveness of NAC in reducing pain symptoms related to endometriosis. I am so pleased for her!

Anxiety details

I take this supplement for anxiety and to aid recovery from concussions. I’ve never been prescribed anything for anxiety because I often don’t persist with treatments. However, I found relief from my racing thoughts very quickly with this product. If only the pills weren’t so large, I’d be happier!

Heart Attack details

It supports heart and blood vessel health, and I recommend it for those over the age of forty.

Food Poisoning details

This is an excellent product with a great composition. I used it after suffering from heavy metal food poisoning, and it provided significant relief.

Kidney Stones details

SCIENTIFIC SCORE

Possibly Effective

Based on 4 Researches

Cystine stone prevention with NAC

Cystine Renal Calculi: New Aspects Related to Their Formation and Development.

Most Relevant Research

We observed how n-acetyl-L-cysteine can impact the formation of cystine kidney stones. The study utilized crystallization experiments to mimic conditions similar to those in the kidneys. Cystine typically requires high supersaturation to crystallize, presenting a challenge since inhibitors, like n-acetyl-cysteine, tend to have reduced effects under such conditions.

Our findings highlighted that in the absence of crystallization inhibitors, crystallization begins within just 15 minutes. However, when n-acetyl-L-cysteine and other thiol agents like penicillamine and tiopronin were present, they completely blocked the crystallization process. Notably, n-acetyl-L-cysteine didn't just stop the formation of cystine crystals; it also altered their shape, which could play a vital role in how stones develop.

Moreover, we explored the structure of 30 cystine stones and found that they start from small crystals, continuously growing into larger structures depending on where they form in the kidney. The prevention of stone development hinges on keeping urinary cystine levels low, which n-acetyl-L-cysteine emerged as the most effective method among those tested. Increased hydration and physical activity further showed promise in helping remove cystine crystals and preventing stone formation.

9.5

Protects kidneys

Most Useful Review

This N-acetyl-L-cysteine (600 mg) from Life Extension is an effective antioxidant that protects my kidneys and liver from toxins. It also maintains respiratory health and supports the synthesis of intracellular glutathione, crucial for cellular processes. NAC is beneficial for both active and older individuals. I highly recommend this supplement.

Sleep Apnea details

Very great! I had a persistently congested chest from smoking and just two days after starting this wonderful supplement, I was able to sleep again without being troubled by the wheezing in my chest. My breathing is much better now, and I can't live without it anymore. I have tested other brands, but this one had the best effect.

Diarrhea details

SCIENTIFIC SCORE

Likely Very Effective

NAC improves rifaximin treatment outcomes

Low dose rifaximin combined with N-acetylcysteine is superior to rifaximin alone in a rat model of IBS-D: a randomized trial.

Most Relevant Research

In our exploration of new treatment options for diarrhea, we found that combining n-acetylcysteine (NAC) with rifaximin might improve outcomes for patients suffering from irritable bowel syndrome with diarrhea (IBS-D). The study involved a validated rat model, where we assessed the effects of various combinations of these treatments after inducing IBS-D with a specific toxin.

We observed that when rats were treated with rifaximin alone, their stool consistency and bacterial levels did not significantly improve compared to those that received a placebo. However, those treated with rifaximin combined with NAC showed marked improvements. Their stool consistency normalized, and the levels of harmful bacteria, including E. coli, were significantly reduced.

Furthermore, the combined treatment also led to a normalization of cytokine levels, which are molecules linked to inflammation and diarrhea. This suggests that NAC not only supports the action of rifaximin but may also enhance overall treatment effectiveness for IBS-D. Our findings highlight the promising potential of using NAC alongside rifaximin to better manage diarrhea symptoms in affected patients.

6.3

Intense diarrhea

Most Useful Review

Diarrhoea! It gave me intense diarrhoea.