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Supplement Facts
Serving Size: 3 Vegetarian Capsules
Amount Per Serving
%DV
Magnesium (from 2,000 mg Magtein® magnesium L-threonate)
144 mg
34%
The product is found useful for the following medical conditions
Migraine
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 58 Reviews
8.8
9
We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
10
Miracle product
Most Useful Review
For over a decade, I struggled with migraines triggered by various factors. Typically, I experienced 6-8 migraines monthly. Since using this product, I've tolerated it well and noticed a significant drop in migraines – only one compared to the usual 4-5 by now. Even when exercising, a major trigger, I've felt fine. I will continue to monitor its effects, as this truly feels miraculous.
Common Cold
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.7
9.5
Significant cold relief
Most Useful Review
The product is excellent; it expands my chest and lifts my spirits. It’s especially beneficial for those struggling with sleep—just take it early for a good night’s rest. I believe it helps my nerves and extremities, as I was suffering from a severe cold, and it has markedly alleviated my symptoms. Although this company is quite pricey, their product is meticulously crafted, with a size that's somewhat fitting, though slightly large, as shown in the pictures. May God bless you and your endeavours.
Cancer
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.6
USERS' SCORE
Good
Based on 2 Reviews
8.7
8
Magnesium alloy inhibits cancer growth
Biodegradable Mg-1%Ca alloy inhibits the growth of cervical cancer.
Most Relevant Research
We explored how magnesium alloy, particularly a variant containing 1% calcium, impacts cervical cancer cells. Our investigation revealed that this alloy has promising antitumor properties which could pave the way for new treatments.
In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.
Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.
With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.
In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.
Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.
With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.
9.5
Neuropathy relief
Most Useful Review
Initially sceptical, I followed my functional medicine doctor's advice to take this twice nightly. After two weeks, I noticed a major improvement; the burning sensation in my heels, a side effect of blood cancer treatment, completely vanished. I've also observed a significant reduction in ADHD symptoms. My anxiety has lessened, and now I can manage tasks without feeling overwhelmed. Overall, I feel mentally improved and highly recommend this product.
Neuropathy
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.7
9
Magnesium's potential in neuropathy treatment
Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models.
Most Relevant Research
A recent study explored the connection between magnesium levels and diabetic sensorimotor polyneuropathy. We measured serum magnesium and plasma methylglyoxal levels in recently diagnosed type 2 diabetes patients—some with neuropathy and others without.
Our findings revealed that patients with neuropathy had significantly lower magnesium levels, which were inversely related to higher methylglyoxal levels. This interaction appeared to contribute to nerve dysfunction, making magnesium's role particularly interesting in the context of neuropathy.
We found that magnesium supplementation could protect nerve cells from the neurotoxic effects of methylglyoxal in laboratory models. Importantly, when magnesium was added, we observed improvements in cell health, suggesting that maintaining magnesium levels might be a promising strategy for mitigating diabetic neuropathy.
Overall, our research highlights a compelling link between magnesium deficiency and nerve damage, suggesting that addressing magnesium levels could hold the key to new treatment approaches for diabetic neuropathy and possibly other neurodegenerative conditions.
Our findings revealed that patients with neuropathy had significantly lower magnesium levels, which were inversely related to higher methylglyoxal levels. This interaction appeared to contribute to nerve dysfunction, making magnesium's role particularly interesting in the context of neuropathy.
We found that magnesium supplementation could protect nerve cells from the neurotoxic effects of methylglyoxal in laboratory models. Importantly, when magnesium was added, we observed improvements in cell health, suggesting that maintaining magnesium levels might be a promising strategy for mitigating diabetic neuropathy.
Overall, our research highlights a compelling link between magnesium deficiency and nerve damage, suggesting that addressing magnesium levels could hold the key to new treatment approaches for diabetic neuropathy and possibly other neurodegenerative conditions.
9.5
Major improvement seen
Most Useful Review
Initially sceptical, I decided to try this product as directed by my doctor. After two weeks, the burning sensation in my heels from neuropathy has vanished. Moreover, my mental fog has cleared, I feel more relaxed and prioritised tasks better. This product not only lessened my neuropathy but appeared to enhance my mood and focus. Highly recommend!
Constipation
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.6
USERS' SCORE
Good
Based on 17 Reviews
8.6
4
Effectiveness of magnesium on constipation
Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study.
Most Relevant Research
We explored how changing the frequency of magnesium oxide (MgO) doses influences its effectiveness in relieving constipation. In this study, we looked at 11 patients who had been regularly using MgO to manage their bowel movements and decided to reduce their daily dose frequency over two weeks.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
9.5
Mood improvement noted
Most Useful Review
If you have depression with mild constipation, this may truly help. I had mild constipation for ten years, often going every three to four days. Recently, I started taking six pills each morning for two weeks. Surprisingly, my mood improved significantly, and I began going daily, feeling energetic and confident for the first time in years. My depression has subsided completely without the need for anti-depressants. If you struggle with these issues, this could be your golden ticket to relief.
Heart Attack
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.7
USERS' SCORE
Good
Based on 4 Reviews
8.6
9
Magnesium implantation improves heart recovery
Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats.
Most Relevant Research
We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
8.8
Reduced arrhythmia
Most Useful Review
It has helped with my heart disease. Due to a carbohydrate-restricted diet, I experienced worsening arrhythmia from chronic cardiac issues. After researching, I realised this diet lacks magnesium, which burdens the heart. Since trying this magnesium supplement, my arrhythmia has significantly decreased.
Asthma
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.6
8
Magnesium sulfate aids pediatric asthma
Pharmacokinetics and Pharmacodynamics of Intravenous Magnesium Sulfate in Pediatric Acute Asthma Exacerbations.
Most Relevant Research
We explored how intravenous magnesium sulfate (IVMg) can help children facing severe asthma attacks. The study included 49 pediatric patients who were treated with IVMg after presenting to the emergency department. Some received a placebo, while others were given either 50 or 75 mg/kg of magnesium.
Our analysis showed that higher magnesium levels in the blood were linked to improvements in asthma symptoms, specifically reductions in the Pediatric Respiratory Assessment Measure scores. This suggests that IVMg could be an effective treatment for moderate to severe asthma exacerbations in children.
Interestingly, we noticed that only two out of 31 participants experienced hypotension, showcasing the safety of IVMg, as severe side effects are rare. Moreover, we proposed that a total serum magnesium area under the concentration-time curve greater than 63.1 mg h/L might be a useful target for effective dosing. Further research in larger studies is necessary to confirm these findings, but they indicate that IVMg could serve as a beneficial adjunct treatment for young patients suffering from asthma attacks.
Our analysis showed that higher magnesium levels in the blood were linked to improvements in asthma symptoms, specifically reductions in the Pediatric Respiratory Assessment Measure scores. This suggests that IVMg could be an effective treatment for moderate to severe asthma exacerbations in children.
Interestingly, we noticed that only two out of 31 participants experienced hypotension, showcasing the safety of IVMg, as severe side effects are rare. Moreover, we proposed that a total serum magnesium area under the concentration-time curve greater than 63.1 mg h/L might be a useful target for effective dosing. Further research in larger studies is necessary to confirm these findings, but they indicate that IVMg could serve as a beneficial adjunct treatment for young patients suffering from asthma attacks.
9.5
Dramatic breathing improvement
Most Useful Review
This product has worked where others failed. For three years, I struggled with asthma and heart issues. After starting magnesium supplements for my heart, I noticed my breathing improved significantly. Once I ran out of this product, my asthma symptoms returned, but they disappeared again upon restarting it. I won't stop using it.
Leg Cramps
SCIENTIFIC SCORE
Likely Ineffective
Based on 16 Researches
4.7
USERS' SCORE
Good
Based on 1 Review
8.6
9
Magnesium oxide treats leg cramps
A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
Most Relevant Research
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
10
Life-changing solution
Most Useful Review
This is the first time I’ve left a review. This product is a game changer for night-time leg cramps. Within two days of following the dosage, I experienced no cramps during the night, which I had suffered from for 15 years. It improved my sleep by preventing disruption from leg cramps, and I no longer need muscle relaxants that make me groggy.
Chest Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.1
USERS' SCORE
Good
Based on 8 Reviews
8.5
8
Magnesium supplementation aids chest pain
The prevalence of hypomagnesaemia in pediatric patients with mitral valve prolapse syndrome and the effect of mg therapy.
Most Relevant Research
We explored the effects of magnesium treatment on chest pain in pediatric patients suffering from mitral valve prolapse syndrome. In our study involving 230 young participants, we defined hypomagnesaemia as having a serum magnesium level below 1.5 mg/dl.
After identifying 19 patients with insufficient magnesium levels—representing about 8.2% of the group—we treated them with an oral magnesium chloride supplement for five weeks. We were eager to see whether this would help alleviate symptoms, particularly chest pain.
After the treatment period, we observed that magnesium therapy provided statistically significant relief of chest pain for these patients. However, we did not find substantial improvements in other symptoms like palpitations, fatigue, and dyspnea. This finding is vital, as it indicates that while magnesium may play a role in easing chest pain, its overall benefit to other symptoms remains uncertain.
Overall, our study highlights the relatively low prevalence of magnesium deficiency in pediatric patients with mitral valve prolapse compared to adults. Nevertheless, we concluded that magnesium supplementation could be a beneficial approach to address specific symptoms like chest pain in this population.
After identifying 19 patients with insufficient magnesium levels—representing about 8.2% of the group—we treated them with an oral magnesium chloride supplement for five weeks. We were eager to see whether this would help alleviate symptoms, particularly chest pain.
After the treatment period, we observed that magnesium therapy provided statistically significant relief of chest pain for these patients. However, we did not find substantial improvements in other symptoms like palpitations, fatigue, and dyspnea. This finding is vital, as it indicates that while magnesium may play a role in easing chest pain, its overall benefit to other symptoms remains uncertain.
Overall, our study highlights the relatively low prevalence of magnesium deficiency in pediatric patients with mitral valve prolapse compared to adults. Nevertheless, we concluded that magnesium supplementation could be a beneficial approach to address specific symptoms like chest pain in this population.
9.5
Breathing improved
Most Useful Review
After facing asthma, congestive heart failure, and afib for three years, I began using magnesium supplements. Since starting, my symptoms have vanished, with no chest pain reported. Once I ran out, the problems reappeared, but they disappeared upon restarting the supplements. This has been extremely beneficial for me.
Alzheimer
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.5
8
Magnesium's impact on Alzheimer's treatment
Magnesium-L-threonate treats Alzheimer's disease by modulating the microbiota-gut-brain axis.
Most Relevant Research
We explored the potential benefits of magnesium-L-threonate for Alzheimer's disease, particularly how it interacts with the gut microbiome. In our study, we focused on a specific mouse model that simulates Alzheimer's by using double-transgenic groups expressing particular proteins associated with the disease. By administering magnesium-L-threonate, we aimed to see if it could improve cognitive functions and alter gut bacteria positively.
Our findings revealed that magnesium-L-threonate not only enhanced learning and memory but also significantly altered the balance of gut microbiota. We observed a reduction in the harmful bacteria Allobaculum, while beneficial strains like Bifidobacterium and Turicibacter increased.
Additionally, our research detected changes in serum metabolites linked to neurodegenerative diseases, strengthening the idea that magnesium could play a role in brain health by influencing gut health. Importantly, we also noted improvements in intestinal barrier function, indicating that magnesium-L-threonate might mitigate some effects of Alzheimer's by repairing gut-related issues.
Overall, we believe that magnesium-L-threonate holds promise as a therapeutic option in managing Alzheimer’s symptoms, emphasizing the intricate relationship between the gut and brain in this condition.
Our findings revealed that magnesium-L-threonate not only enhanced learning and memory but also significantly altered the balance of gut microbiota. We observed a reduction in the harmful bacteria Allobaculum, while beneficial strains like Bifidobacterium and Turicibacter increased.
Additionally, our research detected changes in serum metabolites linked to neurodegenerative diseases, strengthening the idea that magnesium could play a role in brain health by influencing gut health. Importantly, we also noted improvements in intestinal barrier function, indicating that magnesium-L-threonate might mitigate some effects of Alzheimer's by repairing gut-related issues.
Overall, we believe that magnesium-L-threonate holds promise as a therapeutic option in managing Alzheimer’s symptoms, emphasizing the intricate relationship between the gut and brain in this condition.
8.3
Improves brain activity
Most Useful Review
Great for Mum. With a family history of dementia and Alzheimer's, she has been taking these for years to maintain her cognitive health. She reports definitive improvements in focus and brain activity, indicating satisfaction with the results.
Hyperthyroidism
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Stabilises energy levels
Most Useful Review
It works. I began taking this supplement to relax my nervous system due to hyperthyroidism, which sometimes makes it hard to fall asleep. Sensitive to medications, I started with just one pill. I immediately felt a difference; I didn’t wake up at night and felt refreshed in the morning. My energy levels during the day were consistently stable. Definitely give it a try.
Insomnia
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.4
USERS' SCORE
Good
Based on 57 Reviews
8.4
9
Magnesium improves elderly insomnia
The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
Most Relevant Research
We conducted a double-blind, placebo-controlled clinical trial to investigate the effects of magnesium supplementation on insomnia in elderly individuals. Our study involved 46 participants who were assigned either to receive 500 mg of magnesium daily or a placebo for a duration of 8 weeks.
Throughout the study, we employed various questionnaires, including the Insomnia Severity Index (ISI), to evaluate the participants' sleep quality both before and after the treatment period. We also monitored the intake of other nutrients and performed blood tests to assess hormone levels related to sleep.
The results showed that magnesium supplementation led to significant improvements in areas such as sleep efficiency, sleep onset timing, and overall insomnia severity. We observed increases in serum levels of melatonin and changes in cortisol and renin levels, indicating a physiological response that could enhance sleep quality.
Overall, it seems that supplementing with magnesium has the potential to improve sleep for older adults struggling with insomnia. This finding could pave the way for new, accessible treatment options for those affected by sleep disorders.
Throughout the study, we employed various questionnaires, including the Insomnia Severity Index (ISI), to evaluate the participants' sleep quality both before and after the treatment period. We also monitored the intake of other nutrients and performed blood tests to assess hormone levels related to sleep.
The results showed that magnesium supplementation led to significant improvements in areas such as sleep efficiency, sleep onset timing, and overall insomnia severity. We observed increases in serum levels of melatonin and changes in cortisol and renin levels, indicating a physiological response that could enhance sleep quality.
Overall, it seems that supplementing with magnesium has the potential to improve sleep for older adults struggling with insomnia. This finding could pave the way for new, accessible treatment options for those affected by sleep disorders.
9.5
Sleep improvement
Most Useful Review
Since taking magnesium threonate, my insomnia has significantly improved. Within five days, I noticed better sleep, falling asleep quickly and not waking during the night. I feel more rested and have greater clarity. My irritability diminished, and my mood became even.
Menopause
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.2
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Magnesium aids menopause-related issues
The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice.
Most Relevant Research
We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
7.5
Improved energy levels
Most Useful Review
My brain is happy. I bought this product at the suggestion of an ob-gyn who specializes in peri/menopause. I noticed a difference within a few days: less brain fog, better sleep, and improved energy throughout the day.
Anxiety
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.9
USERS' SCORE
Good
Based on 77 Reviews
8.3
8
Magnesium treats anxiety in MS
Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
Most Relevant Research
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
8.8
Improved clarity
Most Useful Review
This special form of magnesium has notably enhanced my brain activity, reduced my anxiety, and stabilised my mood. By ensuring proper hydration, I've experienced significant benefits over six days, including clearer thoughts, easier sleep, and greater handling of stress. My eye’s nervous tic has ceased. These results are remarkable for such a short duration of use. I highly recommend it!
Headache
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8
USERS' SCORE
Good
Based on 65 Reviews
8.1
9
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
8.8
Headache relief
Most Useful Review
I became ill with a severe condition, but the post-covid syndrome lasted about three weeks. Symptoms included weakness, forgetfulness, and sleep problems. During this time, magnesium helped me become calmer, alleviating fogginess and improving my memory and sleep. I suffered a terrible headache during covid, which paracetamol couldn’t relieve. Thankfully, magnesium proved effective. Always consult a specialist before taking any medication!
