Supplement Facts
Serving Size: 2 Enteric Coated Softgels
Amount Per Serving
%DV
Calories
25
Total Fat
2.5 g
4%†
Cholesterol
<5 mg
2%†
Pure+™ Wild Fish Oil ConcentrateYielding: EPA (eicosapentaenoic acid)DHA (docosahexaenoic acid)
2,000 mg700 mg500 mg
******
Polyphen-Oil™ Olive extract (fruit and leaf)[providing 19.5 mg polyphenols, 5.2 mg hydroxytyrosol/tyrosol, 4.4 mg verbascoside/oleuropein]
300 mg
**
Sesame seed lignan extract
10 mg
**
The product is found useful for the following medical conditions
Arthritis details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
We analyzed various trials to see how omega-3 fish oil affects rheumatoid arthritis (RA). Our research included 18 randomized controlled studies with 1,018 RA patients. The results showed omega-3 supplementation significantly increased beneficial omega-3 fatty acids, like EPA and DHA, and reduced triglycerides and tender joint count.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
9
Remarkable pain reduction
Most Useful Review
57 people found this helpful
Though I rarely write reviews, this product deserves one. I’ve battled with significant arthritis pain and physical limitations due to injuries from years past. After researching and choosing this supplement, I saw immediate results—NO pain from the very first dose! I've continued taking it and even ordered more. My mobility has substantially improved, and my mother also benefits from it. A true lifesaver for both of us!
Updated: Apr 2025
Cardiovascular Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.7
USERS' SCORE
Good
Based on 3 Reviews
8.5
9
We investigated the link between plasma omega-3 levels and the risk of heart failure (HF) in a large UK cohort study. Our analysis revealed that higher omega-3 levels were associated with a 21% lower chance of developing HF over nearly 14 years.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
9
Pain relief experienced
Most Useful Review
57 people found this helpful
I don’t typically write reviews, but I had to make an exception for this product. After struggling with my weight and chronic pain, I discovered that my issues might be related to arthritis. After I began taking this supplement, my pain vanished almost completely the very next day. I was astonished! My mobility has remarkably improved, and my mother has also experienced enhancement in her knee mobility. This product has truly changed our lives, and I intend to continue using it.
Updated: Mar 2026
Bone Pain details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 4 Reviews
8.4
9
We explored the potential of Resolvin D1 (RvD1) as a non-opioid treatment for bone cancer pain in a mouse model. RvD1 was administered intravenously, showing a remarkable ability to lessen pain effects similarly in both male and female mice.
We found that a single dose effectively reduced pain, while daily treatments eliminated it entirely. Notably, sex didn't influence the pain or treatment efficacy, opening doors for RvD1 as a viable alternative to opioids in managing bone cancer pain.
We found that a single dose effectively reduced pain, while daily treatments eliminated it entirely. Notably, sex didn't influence the pain or treatment efficacy, opening doors for RvD1 as a viable alternative to opioids in managing bone cancer pain.
9
Inflammation relief
Most Useful Review
The quality is outstanding; the ingredients are the finest. After 12 years, I still find the antioxidants beneficial for my entire body. The packaging is convenient, and it reduces inflammation effectively. I’ve noticed improvements in my joints, skin, hair, and nails. The taste is neutral and easy to consume. It noticeably alleviates pain and even supports cognitive health. I wholeheartedly recommend it to everyone.
Updated: Apr 2025
Pelvic Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.1
USERS' SCORE
Good
Based on 6 Reviews
8.4
9
We explored the effects of omega-3 fatty acids from Clupeonella grimmi fish oil on dysmenorrhoea through a clinical trial involving 36 young women. Participants were split into two groups; one received fish oil while the other received a placebo.
After three months, those taking fish oil reported significantly less pain, with visual analogue scale scores showing a marked improvement. Notably, there was also a reduction in low back and abdominal pain, and less reliance on ibuprofen.
Overall, omega-3 fish oil appears to effectively reduce pelvic pain associated with menstrual cycles.
After three months, those taking fish oil reported significantly less pain, with visual analogue scale scores showing a marked improvement. Notably, there was also a reduction in low back and abdominal pain, and less reliance on ibuprofen.
Overall, omega-3 fish oil appears to effectively reduce pelvic pain associated with menstrual cycles.
9
Joint pain relief
Most Useful Review
I can't live without this product every day for joint pain and mobility. It helps alleviate soreness and arthritis pain on a daily basis.
Updated: Apr 2025
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 3 Reviews
8.3
8
We focused on how Resolvin D1 (RvD1), a pro-resolving lipid, impacts systemic lupus erythematosus (SLE). Our study measured RvD1 levels and T follicular helper (Tfh) cell counts in SLE patients versus healthy individuals.
We found that higher RvD1 levels correlated with lower disease activity and fewer Tfh cells. RvD1 was effective in reducing Tfh cell activity in a mouse model and inhibited Tfh differentiation in lab tests.
Overall, RvD1 appears to play a significant role in managing SLE by suppressing Tfh cells and influencing immune responses.
We found that higher RvD1 levels correlated with lower disease activity and fewer Tfh cells. RvD1 was effective in reducing Tfh cell activity in a mouse model and inhibited Tfh differentiation in lab tests.
Overall, RvD1 appears to play a significant role in managing SLE by suppressing Tfh cells and influencing immune responses.
7.5
Skin improvement
Most Useful Review
7 people found this helpful
This is not the first time I have ordered this Omega 3. Excellent quality and good dosage. I purchased the first jar upon a beautician's recommendation due to dryness on my feet. After a week of taking it, I noticed significant improvement. The capsules are large, matte, and opaque, but not difficult to swallow. Each capsule contains oily liquid, not jelly as mentioned in some reviews. I take one capsule twice a day along with vitamin C.
Updated: Mar 2026
Brain Tumor details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.2
USERS' SCORE
Good
Based on 3 Reviews
8.3
9
We delved into the potential of omega-3 polyunsaturated fatty acids, specifically docosahexaenoic acid (DHA), to combat glioblastoma, one of the most aggressive brain tumors.
In our study, we found that DHA treatment led to cell death in glioblastoma cells, as evidenced by signs of apoptosis and increased autophagy. Furthermore, tests in transgenic mice revealed a notable reduction in tumor size and increased activity reflected in cell death markers.
While these findings suggest a promising avenue for GBM treatment, further research is needed to fully understand how omega-3 fatty acids could be integrated into cancer therapies.
In our study, we found that DHA treatment led to cell death in glioblastoma cells, as evidenced by signs of apoptosis and increased autophagy. Furthermore, tests in transgenic mice revealed a notable reduction in tumor size and increased activity reflected in cell death markers.
While these findings suggest a promising avenue for GBM treatment, further research is needed to fully understand how omega-3 fatty acids could be integrated into cancer therapies.
9
Improved brain function
Most Useful Review
My experience with Life Extension Advanced Omega-3 has been excellent. After using it, I noticed a clear improvement in my cardiovascular health, with stabilized blood pressure and lipid levels. My brain feels clearer, and I've seen enhancements in my concentration and memory. I highly recommend it for anyone concerned about brain function and cardiovascular health.
Updated: Mar 2026
Blood Clot details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.2
9.5
We analyzed the effects of fish oil lipid emulsion on the prevention of deep vein thrombosis in children with intestinal failure.
In this study, we compared 35 pediatric patients receiving a soy oil lipid emulsion with 35 who received fish oil.
Remarkably, none of the children in the fish oil group experienced blood clots, whereas the soy oil group had ten cases. This suggests that fish oil lipid emulsion may significantly reduce the risk of clots associated with central venous catheters.
In this study, we compared 35 pediatric patients receiving a soy oil lipid emulsion with 35 who received fish oil.
Remarkably, none of the children in the fish oil group experienced blood clots, whereas the soy oil group had ten cases. This suggests that fish oil lipid emulsion may significantly reduce the risk of clots associated with central venous catheters.
7.5
Positive blood test
Most Useful Review
A doctor noted that my Omega 3 supplementation was responsible for my favourable blood test results in the relevant category. Since changing doctors, he inquired about my supplements, highlighting the benefits related to my blood health.
Updated: Mar 2026
Heart Attack details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.1
USERS' SCORE
Good
Based on 8 Reviews
8.1
9
Omega-3s' mixed effects on heart health
We examined the impact of omega-3 fatty acids, often found in fish oil, on heart attack risks, particularly in patients with high triglyceride levels. The studies indicate that while omega-3s can effectively lower triglycerides and reduce certain cardiovascular disease outcomes, including fatal heart attacks, their overall benefit remains debated. Despite extensive research demonstrating some positive outcomes, many experts still question the magnitude of their effects on heart attack prevention. Improved guidance on omega-3 supplementation is still evolving as new evidence emerges.
9
Supports heart health
Most Useful Review
1 people found this helpful
This excellent supplement has greatly supported my heart health and improved my cognitive function while reducing inflammation. The results have been remarkable, and I plan to continue using it. I've noticed better heart function and an overall sense of alertness, along with improved focus after a few weeks of use, as well as a reduction in mild fatigue post-exercise.
Updated: Mar 2026
Heart Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Good
Based on 16 Reviews
8.1
9
We examined the relationship between plasma omega-3 levels and heart failure (HF), focusing on how this affects mortality in patients with existing HF. Our analysis of the UK Biobank, which included nearly 272,000 participants without HF, showed that higher omega-3 levels were linked to a 21% lower risk of developing HF over nearly 14 years.
For those already diagnosed with HF, higher omega-3 levels significantly reduced the risk of all-cause and cardiovascular mortality by around 50%. These findings suggest that boosting omega-3 intake could be beneficial for heart health.
For those already diagnosed with HF, higher omega-3 levels significantly reduced the risk of all-cause and cardiovascular mortality by around 50%. These findings suggest that boosting omega-3 intake could be beneficial for heart health.
9
Improved heart function
Most Useful Review
1 people found this helpful
An excellent supplement for bolstering heart health, enhancing cognitive function, and reducing inflammation. I’m pleased with the outcomes and will continue its use. I recommend it for improving cardiovascular health; I’ve noticed an enhancement in heart function and an overall feeling of alertness, alongside better concentration. After a few weeks, my heart function improved, and I experienced less fatigue post-exercise.
Updated: Apr 2025
High Cholesterol details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Good
Based on 15 Reviews
8
9
We conducted a comprehensive trial to understand how different types of omega-3 fatty acids affect cholesterol levels and inflammation in adults struggling with high cholesterol.
Over 12 weeks, participants took various doses of omega-3s, including EPA and DHA, revealing notable benefits. Those receiving higher doses of EPA and DHA saw their triglycerides drop significantly—by up to 15.78%—compared to controls.
Interestingly, ALA supplementation did not lead to improvements in cholesterol or inflammation status, highlighting the superior role of EPA and DHA in managing these health issues.
Over 12 weeks, participants took various doses of omega-3s, including EPA and DHA, revealing notable benefits. Those receiving higher doses of EPA and DHA saw their triglycerides drop significantly—by up to 15.78%—compared to controls.
Interestingly, ALA supplementation did not lead to improvements in cholesterol or inflammation status, highlighting the superior role of EPA and DHA in managing these health issues.
7.5
Family health boost
Most Useful Review
321 people found this helpful
Excellent! Omega 3 lowers cholesterol levels, reduces inflammation and improves skin and hair quality. The taste of fish is noticeable, but the quality and composition are excellent, as is the dosage. Although the price has increased due to dollar surges, prioritising health is essential. It's suitable for the whole family, with ample packaging for everyone.
Updated: Mar 2026
Data last updated:
