Life Extension Vitamin D3

We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.

Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.

Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.

9.5

No colds now

Most Useful Review

Elixir of Life I had a severe vitamin D deficiency, and after my doctor prescribed aquadetrim, I decided to try this drug instead, which I do not regret at all. My vitamin D levels normalised within two months. Additionally, I noticed a significant improvement in my immunity. As the cold season began, many around me fell ill, but I remained unaffected. On one occasion, I did get sick, yet recovered in just four days with minimal symptoms. Previously, I suffered from colds almost continuously from September to April! This product has delighted me, and I will continue taking it at a lower dosage to maintain my vitamin D levels through the winter.

Pelvic Pain details

I ordered this product for my niece, who had lethargy and bone pain due to vitamin D deficiency. She started with a high dose once a week and then continued using it daily, resulting in significant improvement, God willing.

Bone Pain details

SCIENTIFIC SCORE

Moderately Effective

Based on 3 Researches

Vitamin D3 correction improves pain

Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty.

Most Relevant Research

We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.

By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.

Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.

9.5

Reduced bone pain

Most Useful Review

This has been an absolute lifesaver for me. I suffer from chronic pain due to fibromyalgia, and after a month of taking this high dose vitamin D3, my bone pain has decreased significantly.

High Cholesterol details

SCIENTIFIC SCORE

Possibly Effective

Based on 20 Researches

Vitamin D lowers cholesterol levels

Vitamin D Supplementation Reduces Hyperlipidemia and Improves Bone Mass in Pediatric Obesity.

Most Relevant Research

We investigated how vitamin D3 supplementation impacts cholesterol levels in pediatric patients with obesity. During our study, we divided 723 children into two groups: one received vitamin D3 supplements, while the other received a placebo. This allowed us to comprehensively assess the relationship between vitamin D and metabolic health, especially focusing on high cholesterol.

What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).

Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.

9.5

High level attained

Most Useful Review

I was significantly below the required vitamin D levels, but this product raised my level to the high side within three months. I've since reduced the dosage, as I reached my target.